@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR6B3_HUMAN: (2016-01-13 )
MSGENVTRVGTFILVGFPTAPGLQYLLFLLFLLTYLFVLVENLAIILTVWSSTSLHRPMYYFLSSMSFLEIWYVSDITPKMLEGFLLQQKRISFVGCMTQLYFFSSLVCTECVLLASMAYDRYVAICHPLRYHVLVTPGLCLQLVGFSFVSGFTISMIKVCFISSVTFCGSNVLNHFFCDISPILKLACTDFSTAELVDFILAFIILVFPLLATMLSYAHITLAVLRIPSATGCWRAFFTCASHLTVVTVFYTALLFMYVRPQAIDSRSSNKLISVLYTVITPILNPLIYCLRNKEFKNALKKAFGLTSCAVEGRLSSLLELHLQIHSQPL
Atome Classification :
(20 SA)
--....-----.....10........---------------20.....--------...30.....----...40........50........60........70......-..---80.....-...90......----..100...-------....110.......120.......130---....---....140.......150.......160-....----------...170.......180..-.....--------190------.--........200.......210.......220......-------.-----230----------------------------------------------------------------------------------------------------------------------------------------------------------------.-------------------------------------------------------------------------------------------------------------------------------------------------------------------........240.......250....--------...260....------------.------------..270.------......280.......290.......300.......310--.......320..-.....330
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--MSGE-----N
V
T
R
V
G
T
F
I
L
V
GFPT---------------AP
G
L
Q
Y
L
--------
L
F
L
L
F
L
L
T
Y
L
----
F
V
L
V
EN
L
A
I
I
L
T
VWSSTSLH
R
P
M
Y
Y
F
L
S
SM
S
F
L
E
I
W
Y
VSDI-
T
P
---
K
M
L
E
G
F
L
-
L
Q
Q
K
R
I
S
F
V
G
C
----
M
T
Q
L
Y
F
F
S
-------
S
L
V
C
T
E
C
V
L
L
A
S
M
A
YD
R
Y
V
A
ICH
P
L
R
----
Y
H
V
L
---VT
P
G
L
C
L
Q
L
V
G
F
S
F
VS
G
F
T
I
S
M
I
K
V
C
F
-IS
S
V
----------
T
F
C
G
S
N
V
L
N
H
F
F
C
D
I
S
P
I
-
L
K
L
AC--------T--------D--F
S
T
A
E
L
V
D
F
I
L
A
F
I
I
L
V
F
P
L
L
A
T
M
L
S
Y
A
H
I
T
L
A
V
L
RI-------P-----S------------------------------------------------------------------------------------------------------------------------------------------------------------------A-------------------------------------------------------------------------------------------------------------------------------------------------------------------T
G
C
W
R
A
F
F
T
C
A
S
H
L
T
V
V
T
V
F
Y
T
A
L
L
--------
F
M
YVRPQAID------------S------------RSSN
K
L
------
I
S
V
L
Y
T
V
I
T
P
I
L
N
P
L
I
Y
C
LR
N
K
E
F
K
N
A
L
K
K
A
FGL
T
S
C
A
V
--
E
G
R
L
S
S
L
L
E
L
H
L
-
Q
IHSQPL-
35
HHSearch
92.55
19%
-158
- C3 -
3EML
13
ENLYS_BPT4
A:
[20-472]
--------------------------------------------
G
S
S
V
--------
Y
I
T
V
E
L
A
I
A
V
----
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
---
F
A
I
T
I
S
T
---
G
F
C
A
A
C
H
G
C
----
L
F
I
A
C
F
V
L
-------
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
----
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
-
W
N
N
C
----------
G
Q
-------
S
Q
G
C
G
E
G
Q
V
----
A
C
--------
L
--------
F
ED
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
-------
L
-----
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
--------
I
I
N
C
F
T
F
F
C
P
DCSH--------
A
------------
P
L
W
L
M
Y
------
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
-----------------------
50
Fugue
88.90
17%
-133
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
--
M
N
G
T
E
G
PNF
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
---------------
E
A
P
Q
Y
Y
L
AE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
----
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
---
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
----
N
L
E
G
F
F
A
T
-------
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
---------------------
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
-
V
M
A
L
----------
A
C
A
-
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
-
M
Q
C
S
C
--------
G
I
DYYTPHE
E
--
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
-
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
AASATTQ
K
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
--------
F
Y
I
F
T
H
Q
G
S
D
------------
F
------------
G
P
I
F
M
T
------
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
--
T
T
V
S
K
T
E
T
S
------
Q
V
A
P
A
-
34
HHSearch
88.48
18%
-146
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
---------------------------------------------
V
V
G
--------
M
G
I
V
M
S
L
I
V
L
----
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
---
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
----
E
F
W
T
S
I
D
V
-------
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
----
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
----------
T
H
-----
Q
E
A
I
N
C
Y
A
E
E
-----
T
C
--------
C
--------
D
--
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
-------
L
-----
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKF-
C
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
--------
I
V
N
I
V
H
V
I
Q
D
NL----------
I
------------
R
K
E
V
Y
I
------
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
----------------------------
5
PsiBlast_PDB
86.76
19%
-144
- C3 -
2YDO
3
?
A:
[18-301]
-----------------------------------------------------------------
V
----
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
I
S
T
G
F
C
-
A
A
C
H
G
C
L
F
I
A
C
----
F
V
L
V
L
T
A
S
-------
S
I
F
S
-----
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
----
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
-
W
N
N
C
GQPK
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
-
N
Y
M
V
Y
--------
F
--------
N
--
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
------------
A
------------
P
L
W
L
M
Y
------
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
--
Q
E
P
F
K
A
A
A
A
E
N
L
-
Y
F
------
4
PsiBlast_PDB
84.65
20%
-136
- C3 -
3VGA
1
AA2AR_HUMAN
A:
[18-301]
-----------------------------------------------------------------
V
----
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
C
-
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
----------------
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
----
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
-
W
N
N
C
GQS-------
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
-
N
Y
M
V
Y
--------
F
--------
N
--
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
-------
E
-----
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
------------
A
------------
P
L
W
L
M
Y
------
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
-------------------------
6
PsiBlast_PDB
84.15
19%
-145
- C3 -
2YDV
6
?
A:
[18-301]
-----------------------------------------------------------------
V
----
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
I
S
T
G
F
C
-
A
A
C
H
G
C
L
F
I
A
C
----
F
V
L
V
L
T
A
S
-------
S
I
F
S
-----
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
----
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
-
W
N
N
C
GQPK
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
-
N
Y
M
V
Y
--------
F
--------
N
--
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
------------
A
------------
P
L
W
L
M
Y
------
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
--
Q
E
P
F
K
A
A
A
A
E
N
L
-
Y
F
Q
-----
8
PsiBlast_PDB
84.06
19%
-137
- C3 -
4UHR
1
AA2AR_HUMAN
A:
[18-301]
-----------------------------------------------------------------
V
----
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
I
S
T
G
F
C
-
A
A
C
H
G
C
L
F
I
A
C
----
F
V
L
V
L
T
A
S
-------
S
I
F
S
-----
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
----
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
-
W
N
N
C
GQPKEGKA---
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
-
N
Y
M
V
Y
--------
F
--------
N
--
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
-------
E
-----
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
-
H
------------
A
------------
P
L
W
L
M
Y
------
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
--
Q
E
P
F
K
A
A
A
A
------------
3
PsiBlast_PDB
83.75
20%
-139
- C3 -
3VG9
8
?
A:
[18-301]
-----------------------------------------------------------------
V
----
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
C
-
A
A
C
H
G
C
L
F
I
A
C
FV
L
V
L
T
Q
S
S
I
F
S
----------------
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
----
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
-
W
N
N
C
GQS-------
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
-
N
Y
M
V
Y
--------
F
--------
N
--
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
-------
E
-----
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
------------
A
------------
P
L
W
L
M
Y
------
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
------------------------
7
PsiBlast_PDB
82.86
19%
-144
- C3 -
4UG2
3
?
A:
[18-301]
-----------------------------------------------------------------
V
----
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
I
S
T
G
F
C
-
A
A
C
H
G
C
L
F
I
A
C
----
F
V
L
V
L
T
A
S
-------
S
I
F
S
-----
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
----
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
-
W
N
N
C
GQPK
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
-
N
Y
M
V
Y
--------
F
--------
N
--
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
------------
A
------------
P
L
W
L
M
Y
------
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
------------------------
51
Fugue
80.77
16%
-123
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
--
M
N
G
T
-----
E
G
P
--
N
F
Y
V
P
F
S
N
K
T
GVVRSPFEAPQYYLA
E
P
W
Q
F
S
M
--------
L
A
A
Y
M
F
L
L
I
M
----
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
---
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
----
N
L
E
G
F
F
A
T
-------
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
---------------------
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
-
V
M
A
L
----------
A
C
A
A
P
P
L
V
G
--
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
DYYTPH
E
--------
E
--
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
-
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
-------
A
AQQQE
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
--------
P
Y
A
G
V
A
F
Y
I
F
------------
T
------------
H
Q
G
S
D
F
GPIFM
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
GD
D
E
A
S
T
T
V
S
K
T
E
T
-
S
Q
V
A
P
A
--
33
HHSearch
80.57
18%
-148
* C3 *
3RZE
5
ENLYS_BPT4 (first)
A:
[9-443]
----------------------------------------------
M
P
--------
L
V
V
V
L
S
T
I
C
L
----
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
---
M
N
I
L
Y
L
L
-
M
S
K
W
S
L
G
R
P
L
C
----
L
F
W
L
S
M
D
Y
-------
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
----
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
-
G
-
W
N
H
------------------
R
R
E
D
K
C
E
T
D
F
Y
-----------------------
D
-----
V
T
W
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
-------
C
-----
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLH-
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
R
E
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
--------
I
F
F
M
V
I
A
F
C
K
------------
N
CC----------
N
E
H
L
H
M
------
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
----------------------------
36
HHSearch
80.44
15%
-153
- C3 -
2Z73
5
OPSD_TODPA
A:
[32-336]
-------------------------------------------
A
V
Y
Y
S
--------
L
G
I
F
I
G
I
C
G
I
----
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
---
L
M
T
I
S
C
F
-
L
K
K
W
I
F
G
F
A
A
C
----
K
V
Y
G
F
I
G
G
-------
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
----
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
-
W
G
A
Y
----------
T
L
----
E
G
V
L
C
N
C
S
F
D
Y
I
-
S
---------------------
R
--
D
S
T
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
-------
E
-----
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
----------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
--------
V
V
A
L
L
A
Q
F
G
P
LEW---------
V
------------
T
P
Y
A
A
Q
------
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
--
Q
F
D
D
K
E
T
E
D
D
K
D
-
A
E
T
E
I
P
A
-
56
Fugue
78.32
18%
-153
- C2 -
4R1D
-
?
B:
[1-301]
MD
K
T
G
W
-----
I
T
H
C
F
G
R
F
L
I
D
L
P
P
D
---------------
A
V
I
N
A
G
Y
--------
Y
L
W
G
D
R
I
E
Y
L
DDK
P
T
E
L
A
A
R
V
D
R
L
E
Q
E
W
R
T
Q
R
H
K
S
K
G
N
M
F
L
R
K
I
D
F
-----------
G
---
N
E
S
V
G
L
L
-
S
W
S
S
E
V
A
S
K
T
Y
----
L
L
D
T
Y
V
T
S
K
P
T
W
H
V
Y
R
W
K
G
K
V
S
V
D
R
E
Q
H
A
V
E
I
S
R
A
L
A
R
N
L
R
S
R
A
P
K
E
I
P
---
S
E
P
G
F
C
I
---
D
H
A
Y
I
A
G
D
--
S
F
Q
V
E
R
F
-
G
V
G
V
----------
T
F
P
E
H
-----------
P
G
-
A
R
F
E
F
--------
R
--------
S
--
S
T
G
A
E
L
N
S
L
L
E
R
V
D
G
F
V
Q
N
M
L
S
T
F
A
G
M
E
T
L
R
K
G
K
H
P
V
-------
G
-----
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
--
E
E
Y
L
V
A
G
S
D
K
G
-----
Q
R
G
Y
T
--------
F
M
W
E
V
Q
G
K
E
E
------------
S
------------
L
T
E
P
N
L
------
T
A
G
L
A
V
L
E
-----------
R
S
N
E
N
G
K
P
P
P
P
A
F
-----
K
S
--
D
K
E
A
L
E
L
W
D
T
I
V
D
S
I
R
V
R
P
T
S
39
HHSearch
78.27
14%
-133
- C3 -
1U19
14
OPSD_BOVIN
A:
[38-329]
-------------------------------------------
W
Q
F
S
M
--------
L
A
A
Y
M
F
L
L
I
M
----
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
---
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
----
N
L
E
G
F
F
A
T
-------
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
----
N
F
R
F
----
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
-
W
S
R
Y
----------
I
P
----
E
G
M
Q
C
S
C
G
I
D
Y
Y
-
T
P
-----------
H
--------
E
--
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
-------
A
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
QQESA
T
T
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
--------
G
V
A
F
Y
I
F
T
H
Q
GSD---------
F
------------
G
P
I
F
M
T
------
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
--
G
D
D
E
A
S
T
T
V
S
K
T
-
E
T
S
Q
V
A
P
-
41
HHSearch
77.91
16%
-149
- C3 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
--------------------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
----
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
-
M
P
---
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
----
D
V
F
V
T
L
D
V
-------
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
----
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
G
-
F
N
T
T
-----------------
G
D
P
T
V
C
S
I
S
N
-----------------------------
P
--
D
F
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
-------
R
-----
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
R
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
--------
L
T
H
V
L
N
T
H
C
Q
TCH---------
V
------------
S
P
E
L
Y
S
------
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
----------------------------
40
HHSearch
77.30
15%
-147
- C3 -
2KS9
1
NK1R_HUMAN
A:
[33-326]
----------------------------------------------
V
L
--------
W
A
A
A
Y
T
V
I
V
V
----
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
---
V
N
F
T
Y
A
V
-
H
N
E
W
Y
Y
G
L
F
Y
C
----
K
F
H
N
F
F
P
I
-------
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
----
P
R
L
-----
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
-
S
T
T
E
----------
T
-----
M
P
S
R
V
V
C
M
I
E
W
P
-
E
H
-----------
P
--------
N
--
K
I
Y
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
-------
E
-----
I
PGDSSDRYH
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
--------
I
F
F
L
L
P
Y
I
N
P
------------
D
LYLKKF------
I
Q
Q
V
Y
L
------
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
--
A
G
D
Y
E
G
L
E
M
K
S
T
-
R
Y
L
Q
T
Q
G
-
38
HHSearch
76.97
17%
-135
- C3 -
3V2Y
1
ENLYS_BPT4
A:
[60-495]
------------------------------------------
E
N
S
I
K
L
--------
T
S
V
V
F
I
L
I
C
C
----
F
I
I
L
E
N
I
F
V
L
L
T
I
W
K
T
K
K
F
H
R
P
M
Y
Y
F
I
G
N
L
A
L
S
D
L
L
A
G
V
A
Y
-
T
A
---
N
L
L
L
S
G
A
--
T
T
Y
K
L
T
P
A
Q
W
----
F
L
R
E
G
S
M
F
-------
V
A
L
S
A
S
V
F
S
L
L
A
I
A
I
E
R
Y
I
T
M
L
K
---------------
N
N
F
R
L
F
L
L
I
S
A
C
W
V
I
S
L
I
L
G
G
L
P
I
M
G
-
W
N
C
I
-----------------
S
A
L
S
S
C
S
T
V
L
P
-
L
---------------------------
Y
H
K
H
Y
I
L
F
C
T
T
V
F
T
L
L
L
L
S
I
V
I
L
Y
C
R
I
Y
S
L
V
R
T
R
-------
N
-----
I
F
E
M
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYA
S
R
-
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
N
V
A
L
L
K
T
V
I
I
V
L
S
V
F
I
A
C
W
A
P
L
F
--------
I
L
L
L
L
D
V
G
C
K
------------
V
KTC
D
--------
I
L
F
R
A
E
------
Y
F
L
V
L
A
V
L
N
S
G
T
N
P
I
I
Y
T
L
T
N
K
E
M
R
R
A
F
I
R
I
M
G
R
P
L
--------------------------
30
HHSearch
76.56
17%
-146
- C3 -
3UON
4
ACM2_HUMAN (first)
A:
[23-457]
---------------------------------------------
V
V
F
--------
I
V
L
V
A
G
S
L
S
L
----
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
---
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
V
V
C
----
D
L
W
L
A
L
D
Y
-------
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
----
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
-
W
Q
F
I
----------
V
G
V
R
--
T
V
E
D
G
E
C
Y
I
Q
F
F
----------------------------
S
N
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
-------
I
-----
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPP-
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
--------
V
M
V
L
I
N
T
F
C
A
PC----------
I
------------
P
N
T
V
W
T
------
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
-----------------------------
31
HHSearch
72.43
14%
-145
- C3 -
3ODU
6
CXCR4_HUMAN (first)
A:
[46-497]
-------------------------------------------
F
N
K
I
F
--------
L
P
T
I
Y
S
I
I
F
L
----
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
-
I
T
-
L
P
---
F
W
A
V
D
A
V
--
A
N
W
Y
F
G
N
F
L
C
----
K
A
V
H
V
I
Y
T
-------
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
----
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
F
-
A
N
V
S
----------
E
-----
A
D
D
R
Y
I
C
D
R
F
Y
P
-----------------------
N
--
D
L
W
V
V
V
F
Q
F
Q
H
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
H
S
-------
G
-----
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
--------
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
T
------------
V
H
K
W
I
S
------
I
T
E
A
L
A
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
T
S
G
R
P
L
E
--
V
L
F
Q
-----------------
42
HHSearch
65.11
13%
-137
- C3 -
2LNL
-
CXCR1_HUMAN
A:
[36-322]
------------------------------------------
T
L
N
K
Y
V
--------
V
I
I
A
Y
A
L
V
F
L
----
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
T
--
L
P
---
I
W
A
A
S
K
--
V
N
G
W
I
F
G
T
F
L
C
----
K
V
V
S
L
L
K
E
-------
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
----
T
L
T
----
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
F
-
R
Q
A
Y
----------
H
P
----
N
N
S
S
P
V
C
Y
E
V
L
G
-
N
------------
D
--------
T
--
A
K
W
R
M
V
L
R
I
L
P
H
T
F
G
F
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
L
R
T
L
F
K
A
-------
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
K
H
R
A
M
R
V
I
F
A
V
V
L
I
F
L
L
C
W
L
P
Y
N
--------
L
V
L
L
A
D
T
L
M
R
------------
T
QVIQE
S
C
E
R
R
N
N
I
G
R
A
L
D
------
A
T
E
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
H
G
--------------------------