@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR8H1_HUMAN: (2016-01-14 )
MGRRNNTNVPDFILTGLSDSEEVQMALFILFLLIYLITMLGNVGMILIIRLDLQLHTPMYFFLTHLSFIDLSYSTVITPKTLANLLTSNYISFMGCFAQMFFFVFLGAAECFLLSSMAYDRYVAICSPLRYPVIMSKRLCCALVTGPYVISFINSFVNVVWMSRLHFCDSNVVRHFFCDTSPILALSCMDTYDIEIMIHILAGSTLMVSLITISASYVSILSTILKINSTSGKQKALSTCASHLLGVTIFYGTMIFTYLKPRKSYSLGRDQVASVFYTIVIPMLNPLIYSLRNKEVKNALIRVMQRRQDSR
Atome Classification :
(20 SA)
--------------.........10.--....--------...20..-------------..---------....30.----------.......40.--------------------.......50...---...-..60....-------------....-----70......--..--80.---.....-..90.........100---...---......110---....--.....120.......130-----------.......140.......150-....--...160....--.....170.---..-....180.-.....-------.-------190.--.-.....200.......210...------------....220-----.......230------------------.--------.----.......240-------.....-.-----..250..----.....260--..-----.---.----...270-.-------.....-.--..280..-----.....290.......300.......310--------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------MGRRNNTNV
P
D
F
--
I
LTG--------LS
D
S
E
E
V
-------------
Q
M
---------
A
L
F
I
L
F
L
----------
L
I
Y
L
I
T
M
LGN--------------------V
G
M
I
L
I
I
R
L
D
L
Q
---LHT-
P
M
Y
F
F
L
T
H
-------------
L
S
FI-----DLSYSTVI--
T
P
--
K
T
L
---
A
N
L
L
T
-
S
N
Y
-
I
S
F
M
G
C
F
A
Q
M
-----
F
F
F
---
V
F
L
G
A
A
E
-----
C
F
L
L
--
S
S
MAY
D
R
Y
V
A
I
CSPLRY
P
-----------
V
I
M
SKR
L
C
C
ALVT
G
P
Y
V
I
S
F
-
I
N
S
F
--
V
N
V
V
--
W
M
S
R
--
L
HFC
D
S
N
V
V
---
R
H
-FFCDTS
P
I
-
L
A
L
S
C-------M-------DTY
D
--
I
-
E
I
M
I
H
I
LAG
S
T
L
M
V
S
L
I
T
I
S
A
------------
S
Y
V
S
I
L
S
-----
T
I
L
K
INST--------------------S--------
G
----
K
Q
K
A
L
S
T
C
A
--------
S
H
L
L
G
-
V
-----
T
I
F
Y
G
T
M
----
I
F
T
Y
LKPR--KS-----Y---S----L
G
R
D
---
Q
-------
V
A
S
V
F
-
Y
--
T
I
V
I
P
M
L
-----
N
P
L
I
Y
S
L
R
N
K
E
V
K
N
A
L
I
R
V
M
Q
R
RQDSR---------------------------------------------------------------------------------------------------------------------------------------------------
41
Fugue
89.92
20%
-147
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
-----------------
M
N
G
T
E
G
P
N
F
--
Y
V
P
F
--------
S
N
K
T
G
V
V
RSPFEAPQYYLAE
P
W
---------
Q
F
S
M
L
A
A
----------
Y
M
F
L
L
I
M
L
G
F
--------------------
P
I
N
F
L
T
L
Y
V
T
V
Q
H
KK
L
R
T
-
P
L
N
Y
I
L
L
N
-------------
L
A
V
A
-----
D
L
F
M
V
F
G
G
--
F
T
--
T
T
L
---
Y
T
S
L
H
-
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
-----
F
F
A
---
T
L
G
G
E
I
A
-----
L
W
S
L
--
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-------------------------
N
F
R
F
G
E
N
H
-
A
I
M
G
--
V
A
F
T
--
W
V
M
A
--
L
A
C
A
A
P
P
L
V
GW
S
R
Y
-
I
P
E
G
-----
M
Q
C
S
C
-------
G
I
DYYTPH
E
E
T
N
--
N
-
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
------------
C
Y
G
Q
L
V
F
-----
T
V
K
E
A
A
A
S
--------------------
A
--------
T
----
T
Q
K
A
E
K
E
V
T
--------
R
M
V
I
I
-
M
-----
V
I
A
F
L
I
C
----
W
L
P
Y
A
G
V
A
--
F
Y
-----
I
---
F
----
T
H
Q
G
---
S
DFGPIFM
T
I
P
A
F
-
F
--
A
K
T
S
A
V
Y
-----
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
TTVSKTETS
Q
V
A
P
A-------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
86.90
18%
-135
- C2 -
2KS9
1
NK1R_HUMAN
A:
[35-324]
------------------------------------------------------------------------
W
A
A
A
Y
T
----------
V
I
V
V
T
S
V
V
G
N
--------------------
V
V
V
M
W
I
I
L
A
H
K
R
---
M
R
T
-
V
T
N
Y
F
L
V
N
-------------
L
A
F
A
-----
E
A
S
M
A
A
F
N
--
T
V
--
V
N
F
---
T
Y
A
V
H
N
E
W
Y
-
Y
G
L
F
Y
C
K
F
H
N
-----
F
F
P
---
I
A
A
V
F
A
S
-----
I
Y
S
M
--
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
-----------
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
-
L
L
A
F
--
P
Q
G
Y
--
Y
-
S
T
----
T
-
E
T
-
M
P
---
S
R
-
V
V
C
M
I
E
W
P
-
E
H
P
N
-----------------
K
I
Y
--
E
-
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
------------
A
Y
T
V
V
G
I
-----
T
L
W
A
S
E
I
P
GDSSDRYH
E
Q
V
---------
S
--------
A
----
K
R
K
V
V
K
M
M
I
--------
V
V
V
C
T
-
F
-----
A
I
C
W
L
P
F
----
H
I
F
F
L
L
P
Y
--
I
N
-----
P
---
D
LYL-
K
K
F
I
Q
Q
V
Y
-------
L
A
I
M
W
-
L
--
A
M
S
S
T
M
Y
-----
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
---------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
85.80
16%
-130
- C2 -
2Z73
5
OPSD_TODPA
A:
[33-333]
----------------------------------------------
V
-------------
Y
Y
---------
S
L
G
I
F
I
G
----------
I
C
G
I
I
G
C
G
G
N
--------------------
G
I
V
I
Y
L
F
T
K
T
K
S
---
L
Q
T
-
P
A
N
M
F
I
I
N
-------------
L
A
F
S
-----
D
F
T
F
S
L
V
N
G
-
F
P
--
L
M
T
---
I
S
C
F
L
K
K
W
I
-
F
G
F
A
A
C
K
V
Y
G
-----
F
I
G
---
G
I
F
G
F
M
S
-----
I
M
T
M
--
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
-----------
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
-
L
W
A
I
--
G
P
I
F
--
G
W
G
A
-----
Y
T
L
-
E
G
---
V
L
-
C
N
C
S
F
D
Y
I
-
S
-------------------
R
D
S
T
--
T
-
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
------------
C
Y
F
N
I
V
M
-----
S
V
S
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
--------
A
----
E
M
R
L
A
K
I
S
I
--------
V
I
V
S
Q
-
F
-----
L
L
S
W
S
P
Y
----
A
V
V
A
L
L
A
Q
--
F
G
-----
P
LEW
V
----
T
P
Y
A
---
A
-------
Q
L
P
V
M
-
F
--
A
K
A
S
A
I
H
-----
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
---------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
80.37
17%
-125
- C2 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
-------------------------------------------
D
E
V
W
-------------
V
V
---------
G
M
G
I
V
M
S
----------
L
I
V
L
A
I
V
F
G
N
--------------------
V
L
V
I
T
A
I
A
K
F
E
R
---
L
Q
T
-
V
T
N
Y
F
I
T
S
-------------
L
A
C
A
-----
D
L
V
M
G
L
A
V
--
V
P
--
F
G
A
---
A
H
I
L
M
-
K
M
W
T
F
G
N
F
W
C
E
F
W
T
-----
S
I
D
---
V
L
C
V
T
A
S
-----
I
E
T
L
--
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
-----------
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
-
L
T
S
F
--
L
P
I
Q
M
H
W
Y
R
A
--
T
H
Q
E
A
I
N
C
Y
---
A
E
E
T
C
C
D
F
F
T
N
-
Q
A
Y
A
I
-------
A
-------
S
S
I
V
--
S
--
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
------------
R
Q
L
N
I
F
E
-----
M
L
R
I
D
E
G
L
--------------------
R
--------
L
----
K
I
Y
K
D
T
E
G
Y
--------
Y
T
I
G
I
-
G
-----
H
L
L
T
K
S
P
----
S
L
N
A
A
K
S
E
--
L
D
-----
K
---
A
----
I
G
R
N
---
T
-------
N
G
V
I
T
-
K
--
D
E
A
E
K
L
F
-----
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
28
HHSearch
80.31
17%
-124
- C2 -
2LNL
-
CXCR1_HUMAN
A:
[38-323]
----------------------------------------------
N
-------------
K
Y
---------
V
V
I
I
A
Y
A
----------
L
V
F
L
L
S
L
L
G
N
--------------------
S
L
V
M
L
V
I
L
Y
S
R
V
---
G
R
S
-
V
T
D
V
Y
L
L
N
-------------
L
A
L
A
-----
D
L
L
F
A
L
-
T
--
L
P
--
I
W
A
---
A
S
K
V
N
-
G
W
I
-
F
G
T
F
L
C
K
V
V
S
-----
L
L
K
---
E
V
N
F
Y
S
G
-----
I
L
L
L
--
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
-----------
T
-
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
-
N
L
S
L
--
P
F
F
L
--
F
R
Q
A
-----
Y
H
P
N
-
N
---
S
S
-
P
V
C
Y
E
V
L
G
-
N
D
----------
T
-------
A
K
W
---
R
-
M
V
L
R
I
L
P
H
T
F
G
F
I
V
P
L
F
V
M
L
F
------------
C
Y
G
F
T
L
R
-----
T
L
F
K
A
H
-
M
--------------------
G
--------
Q
----
K
H
R
A
M
R
V
I
F
--------
A
V
V
L
I
-
F
-----
L
L
C
W
L
P
Y
----
N
L
V
L
L
A
D
T
--
L
M
RTQVI
Q
E--
S
C
E
R
R
N
N
I
G
R
A
-
L
-------
D
A
T
E
I
-
L
--
G
F
L
H
S
C
L
-----
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
H
G
------------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
78.39
17%
-122
- C2 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PNFYVPFS
N
K
T
G
V
V
R
S
P
F
E
A
--
P
Q
Y
Y
--------
L
A
E
P
W
Q
F
-------------
S
M
---------
L
A
A
Y
M
F
L
----------
L
I
-
M
L
G
F
P
I
N
--------------------
F
L
T
L
Y
V
T
V
Q
H
K
K
---
L
R
T
-
P
L
N
Y
I
L
L
N
-------------
L
A
V
A
-----
D
L
F
M
V
F
G
G
--
F
T
--
T
T
L
---
Y
T
S
L
H
-
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
-----
F
F
A
---
T
L
G
G
E
I
A
-----
L
W
S
L
--
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
---------------------------
S
N
F
R
F
G
E
-
N
H
A
I
--
M
G
V
A
--
F
T
W
V
--
M
A
L
A
C
A
A
P
P
---
L
V
-
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
DYYTP
H
-------
E
E
T
N
--
N
-
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
------------
C
Y
G
Q
L
V
F
-----
T
V
K
E
A
A
A
Q
--------------------
Q
--------
Q
ESA
T
T
Q
K
A
E
K
E
V
T
--------
R
M
V
I
I
-
M
-----
V
I
A
F
L
I
C
----
W
L
P
Y
A
G
V
A
--
F
Y
-----
I
---
F
----
T
H
Q
G
---
S
DFGPIFM
T
I
P
A
F
-
F
--
A
K
T
S
A
V
Y
-----
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
GDDEA
S
T
T
V
S
K
TETSQVAPA-------------------------------------------------------------------------------------------------------------------------------
46
Fugue
76.68
19%
-131
- C2 -
4KRT
10
?
A:
[7-353]
---------H
H
H
H
H
M
Q
S
R
N
N
N
N
L
K
G
I
--
D
V
S
N
--------
W
K
G
N
I
N
F
-------------
E
S
---------
V
K
N
D
G
V
E
----------
V
V
Y
I
K
A
T
E
G
N
YFKDKY
A
K
Q
N
Y
E
G
A
K
E
Q
G
L
S
V
G
F
Y
H
F
F
R
A
N
K
G
---
A
K
D
-
Q
A
N
F
F
I
D
Y
-------------
L
N
E
I
GAVNY
D
C
K
L
A
L
D
I
ET
T
E
--
G
V
G
---
V
R
D
L
T
-
S
M
C
-
I
E
F
L
E
E
V
K
R
L
T
G
K
E
V
V
V
Y
---
T
Y
T
S
F
A
N
-----
N
N
L
D
--
S
R
L
G
N
Y
P
V
W
I
A
H
Y
G
V
N
T
P
GANNIWSSWVG
F
Q
Y
S
E
N
G
S
V
A
G
V
N
G
G
---
C
D
-
M
N
E
F
--
T
E
E
I
--
F
I
D
S
--
S
N
F
N
L
D
N
A
T
---
T
K
----
N
V
S
T
K
-
L
N
I
R
A
-------
K
-------
G
T
T
N
--
S
-
K
I
I
G
S
I
P
A
G
E
T
F
K
I
K
W
V
D
E
D
Y
LGW---------
Y
Y
V
E
Y
N
G
-----
V
V
G
Y
V
N
A
D
--------------------
Y
--------
V
----
E
K
L
Q
M
A
T
T
Y
--------
N
----------------------
V
S
T
F
L
N
V
R
--
E
E
-----
G
---
S
----
L
N
S
R
---
I
-------
V
D
K
I
N
-
S
G
D
I
F
R
I
D
W
V
-----
D
S
D
F
I
G
W
Y
R
I
T
T
K
N
G
K
V
G
F
V
N
A
E
F
V
K
K
L--------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
76.02
17%
-134
- C2 -
1U19
14
OPSD_BOVIN
A:
[42-327]
-----------------------------------------------------------------------
M
L
A
A
Y
M
F
----------
L
L
I
M
L
G
F
P
I
N
--------------------
F
L
T
L
Y
V
T
V
Q
H
K
K
---
L
R
T
-
P
L
N
Y
I
L
L
N
-------------
L
A
V
A
-----
D
L
F
M
V
F
G
G
--
F
T
--
T
T
L
---
Y
T
S
L
H
G
Y
F
V
-
F
G
P
T
G
C
N
L
E
G
-----
F
F
A
---
T
L
G
G
E
I
A
-----
L
W
S
L
--
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
-----------
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
-
A
C
A
A
--
P
P
L
V
--
G
W
S
R
-----
Y
I
P
-
E
G
---
M
Q
-
C
S
C
G
I
D
Y
Y
-
T
P
H
-----------------
E
E
T
N
--
N
-
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
------------
C
Y
G
Q
L
V
F
-----
T
V
K
E
A
A
A
Q
--------------------
Q
QESA
T
T
Q
K
A
----
E
K
E
V
T
R
M
V
I
--------
I
M
V
I
A
-
F
-----
L
I
C
W
L
P
Y
----
A
G
V
A
F
Y
I
F
T
H
Q
G
-----
S
---
D
F---
G
P
I
F
---
M
-------
T
I
P
A
F
-
F
--
A
K
T
S
A
V
Y
-----
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
69.05
20%
-187
- C1 -
4R5O
10
?
A:
[2-427]
------------DD
C
E
D
L
H
L
G
N
L
A
H
Y
P
N
V
L
K
G
TFPT
E
S
Q
V
L
E
L
G
E
T
L
-------------
E
I
T
P
E
L
LNPEG
A
T
Y
S
W
L
V
NGKEYSTEP
T
F
S
Y
K
I
D
N
P
C
R
--------------------
A
D
L
S
C
I
I
K
N
K
Y
G
---
K
V
E
M
S
T
S
F
S
S
N
H
NFSK
G
F
F
Y
V
A
DG
T
F
N
F
Y
-----
D
T
E
K
K
T
A
Y
Q
D
C
Y
--
A
S
L
N
AG
K
T
L
G
I
-
G
N
Y
-
D
S
A
N
I
I
H
S
N
G
-----
K
F
Y
---
L
L
V
G
T
S
T
SNRDH
F
Y
I
V
D
A
K
T
L
Y
Y
E
N
S
A
V
V
G
A
N
L
S
G
L
-----------
T
I
L
N
E
Q
--
Y
G
L
V
T
G
D
G
I
R
R
I
D
L
K
S
L
--
N
N
V
R
--
I
K
N
E
R
L
L
C
F
Y
N
S
I
I
Y
---
N
G
-
K
V
L
S
N
D
T
Y
-
K
D
E
S
K
-------
V
-------
K
Y
Y
D
--
V
-
N
E
L
I
A
A
K
E
G
E
A
P
A
V
T
E
L
D
I
I
Q
K
Q
K
I
N
F
V
L
A
KDG
N
V
Y
T
L
E
S
A
DNGC
N
I
V
K
I
K
N
D
--------------------
F
--------
T
----
L
E
K
V
F
A
N
F
Q
PAKGPYHS
S
P
T
I
G
M
V
A
S
ETE
N
I
I
Y
L
V
S
TDG
A
I
Y
K
Y
I
-
L
G
--
D
S
-----
D
---
S
----
L
K
A
P
---
F
-------
I
A
A
E
S
G
V
--
S
I
T
A
P
L
Q
L
NQQS
G
E
L
Y
V
T
Y
T
E
E
R
K
D
E
S
K
I
V
V
Y
S
K
D
G
K
V
L
H
T
V
D
CGESVPS
Q
I
L
F
NN----------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
68.87
22%
-148
- C2 -
2RH1
6
ADRB2_HUMAN (first)
A:
[41-235]
-------------------------------------------------------------
V
---------
G
M
G
I
V
M
S
----------
L
I
V
L
A
I
V
F
G
N
--------------------
V
L
V
I
T
A
I
A
K
F
E
R
---
L
Q
T
-
V
T
N
Y
F
I
T
S
-------------
L
A
C
A
-----
D
L
V
M
G
L
A
V
--
V
P
--
F
G
A
---
A
H
I
L
M
K
M
W
T
-
F
G
N
F
W
C
E
F
W
T
-----
S
I
D
---
V
L
C
V
T
A
S
-----
I
E
T
L
--
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
-----------
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
-
L
T
S
F
--
L
P
I
Q
--
M
H
W
Y
---
R
A
---
T
H
Q
---
E
A
-
I
N
C
Y
A
E
-----
E
T
C
-------
C
-------
D
F
F
T
--
N
-
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
------------
V
Y
S
R
V
F
Q
-----
E
A
K
R
Q
L
N
I
--------------------
F
--------
E
----
M
L
R
I
D
E
G
L
R
--------
L
K
I
Y
K
-
D
-----
T
E
G
Y
Y
T
I
----
G
I
G
H
L
L
T
K
--
S
P
-----
S
---
L
----
N
A
A
K
---
S
-------
E
L
D
K
A
-
I
--
G
R
N
T
N
G
V
-----
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
---------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
66.31
27%
-165
- C2 -
2RH1
5
ADRB2_HUMAN (first)
A:
[36-185]
------------------------------------------
D
E
V
W
V
--------------
V
---------
G
M
G
I
V
M
S
----------
L
I
V
L
A
I
V
F
G
N
--------------------
V
L
V
I
T
A
I
A
K
F
E
R
---
L
Q
T
-
V
T
N
Y
F
I
T
S
-------------
L
A
C
A
-----
D
L
V
M
G
L
A
V
--
V
P
--
F
G
A
---
A
H
I
L
M
-
K
M
W
-
T
--
F
G
N
F
W
C
E
-----
F
W
T
S
I
D
V
L
C
V
T
A
S
-----
I
E
T
L
--
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
-----------
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
-
L
T
S
F
L
P
I
Q
M
H
--
W
Y
R
A
--
T
H
Q
E
A
I
N
C
Y
---
A
E
-
E
T
C
C
D
F
F
T
-
N
Q
A
Y
A
-------
I
-------
A
S
S
I
--
V
-
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
------------
R
Q
L
N
I
F
E
-----
M
L
R
I
D
E
G
L
--------------------
R
--------
L
----
K
I
Y
K
D
T
E
G
Y
--------
Y
T
I
G
I
-
G
-----
H
L
L
T
K
S
P
----
S
L
N
A
A
K
S
E
--
L
D
-----
K
---
A
----
I
G
R
N
---
T
-------
N
G
V
I
T
-
K
--
D
E
A
E
K
L
F
-----
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
---------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
65.91
19%
-158
- C2 -
3EML
8
ENLYS_BPT4
A:
[23-221]
-----------------------------------------------------------------------
V
Y
I
T
V
E
L
----------
A
I
A
V
L
A
I
L
G
N
--------------------
V
L
V
C
W
A
V
W
L
N
S
N
---
L
Q
N
-
V
T
N
Y
F
V
V
S
-------------
L
A
A
A
-----
D
I
A
V
G
V
L
A
--
I
P
--
F
A
I
---
T
I
S
T
--
G
F
C
-
A
A
C
H
G
C
L
F
I
A
-----
C
F
V
---
L
V
L
T
Q
S
S
-----
I
F
S
L
--
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
-----------
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
-
A
I
G
L
--
T
P
M
L
--
G
W
N
N
--
C
G
Q
----------
S
-
Q
G
C
G
E
G
Q
----
V
A
C
-------
L
-------
F
E
D
V
VP
M
-
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
------------
V
Y
L
R
I
F
L
-----
A
A
R
R
Q
L
N
I
--------------------
F
--------
E
----
M
L
R
I
D
E
G
L
R
--------
L
K
I
Y
K
-
D
-----
T
E
G
Y
Y
T
I
----
G
I
G
H
L
L
T
K
--
S
P
-----
S
---
L
----
N
A
A
K
---
S
-------
E
L
D
K
A
-
I
--
G
R
N
T
N
G
V
-----
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
---------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
65.25
27%
-171
- C2 -
3D4S
6
ENLYS_BPT4
A:
[40-186]
---------------------------------------------
W
V
--------------
V
---------
G
M
G
I
V
M
S
----------
L
I
V
L
A
I
V
F
G
N
--------------------
V
L
V
I
T
A
I
A
K
F
E
R
---
L
Q
T
-
V
T
N
Y
F
I
T
S
-------------
L
A
C
A
-----
D
L
V
M
G
L
A
V
--
V
P
--
F
G
A
---
A
H
I
L
M
-
K
M
W
-
T
--
F
G
N
F
W
C
E
-----
F
W
T
S
I
D
V
L
C
V
T
A
S
-----
I
W
T
L
--
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
-----------
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
-
L
T
S
F
L
P
I
Q
M
H
--
W
Y
R
A
--
T
H
Q
E
A
I
N
C
Y
---
A
E
-
E
T
C
C
D
F
F
T
-
N
Q
A
Y
A
-------
I
-------
A
S
S
I
--
V
-
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
------------
R
Q
L
N
I
F
E
-----
M
L
R
I
D
E
G
L
--------------------
R
--------
L
----
K
I
Y
K
D
T
E
G
Y
--------
Y
T
I
G
I
-
G
-----
H
L
L
T
K
S
P
----
S
L
N
A
A
K
S
E
--
L
D
-----
K
---
A
----
I
G
R
N
---
T
-------
N
G
V
I
T
-
K
--
D
E
A
E
K
L
F
-----
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
---------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
65.07
27%
-152
- C2 -
3ZPQ
9
ADRB1_MELGA
A:
[7-162]
-------------------------------------------
S
Q
Q
W
-------------
E
A
---------
G
M
S
L
L
M
A
----------
L
V
V
L
L
I
V
A
G
N
--------------------
V
L
V
I
A
A
I
G
S
T
Q
R
---
L
Q
T
-
L
T
N
L
F
I
T
S
-------------
L
A
C
A
-----
D
L
V
V
G
L
L
V
--
V
P
F
G
A
T
L
---
V
V
R
G
T
-
W
L
W
-
G
S
F
L
-
C
E
L
W
T
-----
S
L
D
---
V
L
C
V
T
A
S
-----
I
E
T
L
--
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
-----------
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
-
L
V
S
F
--
L
-----------------
P
I
M
---
M
H
-
W
W
R
D
E
D
P
--
Q
A
L
K
C
-------
Y
-------
Q
D
P
G
--
C
-
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
------------
L
L
I
M
I
F
V
-----
A
L
R
V
Y
R
E
A
--------------------
K
--------
E
----
Q
S
R
V
M
L
M
R
E
--------
H
K
A
L
K
-
T
-----
L
G
I
I
M
G
V
----
F
T
L
C
W
L
P
F
--
F
L
-----
V
---
N
----
I
V
N
V
---
F
-------
N
R
D
L
V
-
P
--
D
W
L
F
V
A
F
-----
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
---------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
64.94
27%
-154
- C2 -
2Y00
10
ADRB1_MELGA
A:
[7-162]
-------------------------------------------
S
Q
Q
W
-------------
E
A
---------
G
M
S
L
L
M
A
----------
L
V
V
L
L
I
V
A
G
N
--------------------
V
L
V
I
A
A
I
G
S
T
Q
R
---
L
Q
T
-
L
T
N
L
F
I
T
S
-------------
L
A
C
A
-----
D
L
V
V
G
L
L
V
--
V
P
F
G
A
T
L
---
V
V
R
G
T
-
W
L
W
-
G
S
F
L
-
C
E
L
W
T
-----
S
L
D
---
V
L
C
V
T
A
S
-----
I
E
T
L
--
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
-----------
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
-
L
V
S
F
--
L
-----------------
P
I
M
---
M
H
-
W
W
R
D
E
D
P
--
Q
A
L
K
C
-------
Y
-------
Q
D
P
G
--
C
-
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
------------
L
L
I
M
I
F
V
-----
A
L
R
V
Y
R
E
A
--------------------
K
--------
E
----
Q
S
R
V
M
L
M
R
E
--------
H
K
A
L
K
-
T
-----
L
G
I
I
M
G
V
----
F
T
L
C
W
L
P
F
--
F
L
-----
V
---
N
----
I
V
N
V
---
F
-------
N
R
D
L
V
-
P
--
D
W
L
F
V
A
F
-----
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
---------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
64.79
27%
-150
- C2 -
2Y02
10
ADRB1_MELGA
A:
[7-162]
-------------------------------------------
S
Q
Q
W
-------------
E
A
---------
G
M
S
L
L
M
A
----------
L
V
V
L
L
I
V
A
G
N
--------------------
V
L
V
I
A
A
I
G
S
T
Q
R
---
L
Q
T
-
L
T
N
L
F
I
T
S
-------------
L
A
C
A
-----
D
L
V
V
G
L
L
V
--
V
P
F
G
A
T
L
---
V
V
R
G
T
-
W
L
W
-
G
S
F
L
-
C
E
L
W
T
-----
S
L
D
---
V
L
C
V
T
A
S
-----
I
E
T
L
--
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
-----------
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
-
L
V
S
F
--
L
-----------------
P
I
M
---
M
H
-
W
W
R
D
E
D
P
--
Q
A
L
K
C
-------
Y
-------
Q
D
P
G
--
C
-
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
------------
L
L
I
M
I
F
V
-----
A
L
R
V
Y
R
E
A
--------------------
K
--------
E
----
Q
S
R
V
M
L
M
R
E
--------
H
K
A
L
K
-
T
-----
L
G
I
I
M
G
V
----
F
T
L
C
W
L
P
F
--
F
L
-----
V
---
N
----
I
V
N
V
---
F
-------
N
R
D
L
V
-
P
--
D
W
L
F
V
A
F
-----
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
---------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
64.79
27%
-150
- C2 -
2Y01
9
ADRB1_MELGA
A:
[7-162]
-------------------------------------------
S
Q
Q
W
-------------
E
A
---------
G
M
S
L
L
M
A
----------
L
V
V
L
L
I
V
A
G
N
--------------------
V
L
V
I
A
A
I
G
S
T
Q
R
---
L
Q
T
-
L
T
N
L
F
I
T
S
-------------
L
A
C
A
-----
D
L
V
V
G
L
L
V
--
V
P
F
G
A
T
L
---
V
V
R
G
T
-
W
L
W
-
G
S
F
L
-
C
E
L
W
T
-----
S
L
D
---
V
L
C
V
T
A
S
-----
I
E
T
L
--
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
-----------
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
-
L
V
S
F
--
L
-----------------
P
I
M
---
M
H
-
W
W
R
D
E
D
P
--
Q
A
L
K
C
-------
Y
-------
Q
D
P
G
--
C
-
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
------------
L
L
I
M
I
F
V
-----
A
L
R
V
Y
R
E
A
--------------------
K
--------
E
----
Q
S
R
V
M
L
M
R
E
--------
H
K
A
L
K
-
T
-----
L
G
I
I
M
G
V
----
F
T
L
C
W
L
P
F
--
F
L
-----
V
---
N
----
I
V
N
V
---
F
-------
N
R
D
L
V
-
P
--
D
W
L
F
V
A
F
-----
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
---------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
64.75
21%
-139
- C2 -
3RZE
2
ENLYS_BPT4 (first)
A:
[10-200]
-----------------------------------------------------------------------
P
L
V
V
V
L
S
----------
T
I
C
L
V
T
V
G
L
N
--------------------
L
L
V
L
Y
A
V
R
S
E
R
K
---
L
H
T
-
V
G
N
L
Y
I
V
S
-------------
L
S
V
A
-----
D
L
I
V
G
A
V
V
--
M
P
--
M
N
I
---
L
Y
L
L
M
S
K
W
S
-
L
G
R
P
L
C
L
F
W
L
-----
S
M
D
---
Y
V
A
S
T
A
S
-----
I
F
S
V
--
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
-----------
K
Y
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
-
L
W
V
I
--
P
I
L
G
---
W
N
H
----------
R
---
R
E
-
D
K
C
E
T
-------------------------
D
F
Y
--
D
V
T
W
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
------------
F
Y
A
K
I
Y
K
-----
A
V
R
Q
H
C
N
I
--------------------
F
--------
E
----
M
L
R
I
D
E
G
L
R
--------
L
K
I
Y
K
-
D
-----
T
E
G
Y
Y
T
I
----
G
I
G
H
L
L
T
K
--
S
P
-----
S
---
L
----
N
A
A
K
---
S
-------
E
L
D
K
A
-
I
--
G
R
N
T
N
G
V
-----
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
---------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
64.66
27%
-170
- C2 -
3NY9
4
ADRB2_HUMAN (first)
A:
[40-186]
---------------------------------------------
W
V
--------------
V
---------
G
M
G
I
V
M
S
----------
L
I
V
L
A
I
V
F
G
N
--------------------
V
L
V
I
T
A
I
A
K
F
E
R
---
L
Q
T
-
V
T
N
Y
F
I
T
S
-------------
L
A
C
A
-----
D
L
V
M
G
L
A
V
--
V
P
--
F
G
A
---
A
H
I
L
M
-
K
M
W
-
T
--
F
G
N
F
W
C
E
-----
F
W
T
S
I
D
V
L
C
V
T
A
S
-----
I
W
T
L
--
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
-----------
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
-
L
T
S
F
L
P
I
Q
M
H
--
W
Y
R
A
--
T
H
Q
E
A
I
N
C
Y
---
A
E
-
E
T
C
C
D
F
F
T
-
N
Q
A
Y
A
-------
I
-------
A
S
S
I
--
V
-
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
------------
R
Q
L
N
I
F
E
-----
M
L
R
I
D
E
G
L
--------------------
R
--------
L
----
K
I
Y
K
D
T
E
G
Y
--------
Y
T
I
G
I
-
G
-----
H
L
L
T
K
S
P
----
S
L
N
A
A
K
S
E
--
L
D
-----
K
---
A
----
I
G
R
N
---
T
-------
N
G
V
I
T
-
K
--
D
E
A
E
K
L
F
-----
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
---------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
64.48
27%
-150
- C2 -
4AMJ
9
ADRB1_MELGA
A:
[7-162]
-------------------------------------------
S
Q
Q
W
-------------
E
A
---------
G
M
S
L
L
M
A
----------
L
V
V
L
L
I
V
A
G
N
--------------------
V
L
V
I
A
A
I
G
S
T
Q
R
---
L
Q
T
-
L
T
N
L
F
I
T
S
-------------
L
A
C
A
-----
D
L
V
V
G
L
L
V
--
V
P
F
G
A
T
L
---
V
V
R
G
T
-
W
L
W
-
G
S
F
L
-
C
E
L
W
T
-----
S
L
D
---
V
L
C
V
T
A
S
-----
I
E
T
L
--
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
-----------
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
-
L
V
S
F
--
L
-----------------
P
I
M
---
M
H
-
W
W
R
D
E
D
P
--
Q
A
L
K
C
-------
Y
-------
Q
D
P
G
--
C
-
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
------------
L
L
I
M
I
F
V
-----
A
L
R
V
Y
R
E
A
--------------------
K
--------
E
----
Q
S
R
V
M
L
M
R
E
--------
H
K
A
L
K
-
T
-----
L
G
I
I
M
G
V
----
F
T
L
C
W
L
P
F
--
F
L
-----
V
---
N
----
I
V
N
V
---
F
-------
N
R
D
L
V
-
P
--
D
W
L
F
V
A
F
-----
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
---------------------------------------------------------------------------------------------------------------------------------------------------