@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : BTK_HUMAN: (2015-10-04 )
MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
Atome Classification :
(100 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240...-..-..250...-.-.-..260.......270.......280.......290-....-...-300.......-310.......--320.......330.......340.......350.......360.......370.......380......--------------.390.--........400....-...410.......420---.------.--------.-----....430....--..---.--440.......450-.-......460.....-..470.......480.......-490-------------.------.--------..-.....500.......510.......520.......530.---......540.......--550......-...560.......570.......580.......590.......600-.-......610.......620.......630.......640.......650.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
A
A
V
I
L
E
S
I
F
L
K
R
S
QQKKKTSPL
N
F
K
K
R
L
F
L
L
T
V
H
K
L
S
Y
Y
E
Y
D
F
E
RGRRGSKKGS
I
D
V
E
K
I
T
C
V
E
TVVPEKNPPPERQIPRRGE
E
S
S
E
M
E
Q
I
S
I
I
E
RFPY
P
F
Q
V
V
YDEG
P
L
Y
V
FS
P
T
E
E
L
R
K
R
W
I
H
Q
L
K
N
V
I
RY
N
S
D
L
V
Q
KYHP
C
F
W
IDG
Q
Y
L
C
C
S
Q
TAKNAMG
C
Q
I
LENRNGSLKPGSSHRKTKKPLPPTPE
E
D
Q
I
LKKPLPPEPAAAPV
S
T
S
E
L
K
K
V
V
A
L
Y
DYMPMNAND
L
Q
LRKGD
E
Y
F
I
L
E-ES-NLP
W
W
RAR-D-K-NGQEGYIPSNYVTEAED
S
I
E
M
Y
E
W
Y
S
K
HM
T
R
S
Q
A
E
-
Q
L
L
K
-QEG-KEG
G
F
I
V
RDS-SKA
G
K
Y
T
V
S
V
--
F
AKSTG
D
P
Q
G
V
I
R
H
Y
V
V
CSTPQS
Q
Y
Y
L
A
E
K
H
L
F
S
T
I
P
E
L
I
N
Y
HQHN
S
A
G
L
I
S
R
LKYPVSQQNKNAPSTA--------------GL--G--YGSWEI
D
P
K
D
L
T
F
L
K
-
E
LGTGQ
F
G
V
V
K
YGKWR---G------
Q
--------
Y
-----
D
V
A
I
K
M
IKEGS--M
S
---
E
--
D
E
F
I
E
E
A
K
V
M
M
NL-
S
-
H
E
K
L
V
Q
L
Y
G
V
CTKQ-R
P
I
F
I
I
T
E
Y
MAN
G
C
L
L
N
Y
L
R
E
M
-
R
---------------
H
------
R
--------
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
ARNCLVNDQ
G
---
V
V
K
V
SDFG
L
S
R
Y
V
LDD--E--Y
T
S
SVG-SKFPVRWSPP
E
V
L
M
Y
SKFSSKS
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
LGKM
P
Y
E
RFT-N-
S
E
T
A
E
H
I
A
Q
G
L
R
L
YRPHLAS
E
K
V
Y
T
I
M
Y
S
C
W
HEKADER
P
T
F
K
I
L
L
S
N
I
L
D
VMDEES
5
PsiBlast_PDB
84.16
99%
-125
- C1 -
3GEN
1
A:
[16-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
---
F
G
V
V
K
Y
G
K
W
R
---
G
------
Q
--------
Y
-----
D
V
A
I
K
M
I
K
E
G
S
--
M
S
---
E
--
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
-
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
-
R
---------------
H
------
R
--------
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
---
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
--
E
--
Y
T
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
18
PsiBlast_PDB
83.56
99%
-133
- C1 -
3OCT
1
A:
[3-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
--
Q
F
G
V
V
K
Y
G
K
W
R
---
G
------
Q
--------
Y
-----
D
V
A
I
K
M
I
K
-----
M
S
---
E
--
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
-
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
-
R
---------------
H
------
R
--------
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
---
V
V
K
V
S
D
F
G
L
S
R
-------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
---
24
PsiBlast_CBE
83.46
100%
-118
- C1 -
4YHF
2
B:
[9-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--
G
--
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
---
G
------
Q
--------
Y
-----
D
V
A
I
K
M
I
K
E
G
S
--
M
S
---
E
--
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
-
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
-
R
---------------
H
------
R
--------
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
---
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
--
E
--
Y
T
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
11
PsiBlast_PDB
83.45
99%
-133
- C1 -
3PJ1
2
A:
[6-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
---
G
V
V
K
Y
G
K
W
R
---
G
------
Q
--------
Y
-----
D
V
A
I
K
M
I
-------
S
---
E
--
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
-
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
---
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
-
R
-------------------------------
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
---
V
V
K
V
S
D
F
G
L
---------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
8
PsiBlast_PDB
82.99
99%
-123
- C1 -
3PIX
1
A:
[6-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
---
G
------
Q
--------
Y
-----
D
V
A
I
K
M
I
K
E
G
S
--
M
S
---
E
--
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
-
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
-
R
---------------
H
------
R
--------
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
---
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
--
E
--
Y
T
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
14
PsiBlast_PDB
82.98
100%
-120
- C1 -
4ZLY
5
A:
[1-270]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
--
G
--
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
---
G
------
Q
--------
Y
-----
D
V
A
I
K
M
I
K
E
G
S
--
M
S
---
E
--
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
-
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
-
R
---------------
H
------
R
--------
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
---
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
--
E
--
Y
T
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
12
PsiBlast_PDB
82.95
99%
-131
- C1 -
3PJ2
1
A:
[6-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
---
G
V
V
K
Y
G
K
W
R
---
G
------
Q
--------
Y
-----
D
V
A
I
K
M
I
K
E
G
S
--
M
S
---
E
--
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
-
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
-
R
---------------
H
------
R
--------
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
---
V
V
K
V
S
D
F
-----------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
13
PsiBlast_PDB
82.84
99%
-129
- C1 -
3PJ3
1
A:
[6-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
---
G
V
V
K
Y
G
K
W
R
---
G
------
Q
--------
Y
-----
D
V
A
I
K
M
I
--------------
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
-
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
-
R
---------------
H
------
R
--------
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
---
V
V
K
V
S
D
F
------------------------
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
10
PsiBlast_PDB
82.67
99%
-127
- C1 -
3PIZ
1
A:
[6-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
---
G
V
V
K
Y
G
K
W
R
---
G
------
Q
--------
Y
-----
D
V
A
I
K
M
I
-------
S
---
E
--
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
-
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
-
R
---------------
H
------
R
--------
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
---
V
V
K
V
S
D
F
G
L
---------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
22
PsiBlast_CBE
82.66
98%
-121
- C1 -
4RFZ
3
A:
[20-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
---
G
------
Q
--------
Y
-----
D
V
A
I
K
M
I
K
E
G
S
--
M
S
---
E
--
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
-
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
-
R
---------------
H
------
A
--------
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
---
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
--
E
--
Y
T
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
7
PsiBlast_PDB
82.52
99%
-129
- C1 -
3K54
1
A:
[16-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
---
G
------
Q
--------
Y
-----
D
V
A
I
K
M
I
K
--------------
E
F
I
E
E
A
K
V
M
M
N
L
-
S
-
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
-
R
---------------
H
------
R
--------
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
---
V
V
K
V
S
D
F
G
----------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
21
PsiBlast_CBE
82.44
98%
-122
- C1 -
4RG0
1
A:
[20-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
---
G
------
Q
--------
Y
-----
D
V
A
I
K
M
I
K
E
G
S
--
M
S
---
E
--
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
-
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
-
R
---------------
H
------
A
--------
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
---
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
--
E
--
Y
T
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
3
PsiBlast_PDB
82.23
98%
-122
- C1 -
4OTQ
3
A:
[20-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
---
G
------
Q
--------
Y
-----
D
V
A
I
K
M
I
K
E
G
S
--
M
S
---
E
--
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
-
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
-
R
---------------
H
------
A
--------
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
---
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
--
E
--
Y
T
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
15
PsiBlast_PDB
82.16
100%
-120
- C1 -
4ZLZ
5
A:
[1-270]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
--
G
--
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
---
G
------
Q
--------
Y
-----
D
V
A
I
K
M
I
K
E
G
S
--
M
S
---
E
--
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
-
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
-
R
---------------
H
------
R
--------
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
---
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
--
E
--
Y
T
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
114
HHSearch
82.05
39%
-94
- C1 -
2H8H
1
SRC_HUMAN
A:
[87-523]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
F
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
-
N
T
-
E
G
D
W
W
L
A
H
-
S
-
L
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
-
S
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
-
R
L
L
L
N
A
E
N
-
P
R
G
T
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
--
S
D
F
D
-
N
A
K
G
L
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
T
---
S
K
P
Q
T
Q
--------------
G
L
--
A
--
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
---
G
------
T
--------
T
-----
R
V
A
I
K
T
L
K
P
G
T
--
M
S
---
P
--
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
---------------
K
------
Y
--------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
---
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
--
E
--
Y
T
A
R
Q
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
-
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
6
PsiBlast_PDB
82.02
99%
-117
- C1 -
4Z3V
5
A:
[13-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
--
G
--
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
---
G
------
Q
--------
Y
-----
D
V
A
I
K
M
I
K
E
G
S
--
M
S
---
E
--
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
-
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
-
R
---------------
H
------
R
--------
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
---
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
--
E
--
Y
T
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
9
PsiBlast_PDB
82.00
99%
-118
- C1 -
3PIY
1
A:
[6-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
---
G
------
Q
--------
Y
-----
D
V
A
I
K
M
I
-----------
E
--
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
-
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
-
R
---------------
H
------
R
--------
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
---
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
--
E
--
Y
T
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
117
HHSearch
81.96
42%
-95
- C1 -
1OPK
3
ABL1_MOUSE
A:
[44-480]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
G
-
Y
N
H
N
G
E
W
C
E
A
Q
-
T
-
K
-
N
G
-
Q
G
W
V
P
S
N
Y
I
T
P
V
-
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
-
Y
L
L
S
-
S
-
G
-
I
N
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
--
R
Y
------
E
G
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
K
R
--
N
K
P
T
I
Y
--------------
G
V
--
S
PN
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
---
K
Y-----
S
--------
L
-----
T
V
A
V
K
T
L
K
E
D
T
--
M
E
---
V
--
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---------------
Q
------
E
--------
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
---
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
--
Y
T
A
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
17
PsiBlast_PDB
81.86
100%
-119
- C1 -
3OCS
2
A:
[4-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
---
G
------
Q
--------
Y
-----
D
V
A
I
K
M
I
K
E
G
S
--
M
S
---
E
--
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
-
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
-
R
---------------
H
------
R
--------
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
---
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
--
E
--
Y
T
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
N
-
121
HHSearch
81.68
99%
-122
- C1 -
4OT5
3
A:
[20-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
---
G
------
Q
--------
Y
-----
D
V
A
I
K
M
I
K
E
G
S
--
M
S
---
E
--
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
-
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
-
R
---------------
H
------
A
--------
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
---
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
--
E
--
Y
T
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
4
PsiBlast_PDB
81.65
98%
-121
- C1 -
4OTR
3
A:
[20-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
---
G
------
Q
--------
Y
-----
D
V
A
I
K
M
I
K
E
G
S
--
M
S
---
E
--
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
-
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
-
R
---------------
H
------
A
--------
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
---
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
--
E
--
Y
T
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
2
PsiBlast_PDB
81.60
98%
-121
- C1 -
4OT6
1
A:
[18-282]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
---
G
------
Q
--------
Y
-----
D
V
A
I
K
M
I
K
E
G
S
--
M
S
---
E
--
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
-
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
-
R
---------------
H
------
A
--------
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
---
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
--
E
--
Y
T
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
1
PsiBlast_PDB
81.38
98%
-122
- C1 -
4OT5
3
A:
[20-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
---
G
------
Q
--------
Y
-----
D
V
A
I
K
M
I
K
E
G
S
--
M
S
---
E
--
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
-
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
-
R
---------------
H
------
A
--------
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
---
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
--
E
--
Y
T
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
23
PsiBlast_CBE
81.29
98%
-122
- C1 -
4RFY
3
A:
[20-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
---
G
------
Q
--------
Y
-----
D
V
A
I
K
M
I
K
E
G
S
--
M
S
---
E
--
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
-
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
-
R
---------------
H
------
A
--------
F
Q
-
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
---
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
--
E
--
Y
T
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
116
HHSearch
79.70
39%
-98
- C1 -
1QCF
1
HCK_HUMAN
A:
[9-444]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
--
G
E
W
W
K
A
R
S
L
-
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
-
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
-
R
Q
L
L
A
P
G
N
-
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
--
R
D
Y
D
P
-
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
---
K
P
Q
K
P
--------------
W
---
E
--
K
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
---
K
------
H
--------
T
-----
K
V
A
V
K
T
M
K
P
G
S
--
M
S
---
V
--
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
-
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---------------
S
------
K
--------
Q
P
-
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
---
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
--
E
--
Y
T
A
R
E
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
-
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
56
PsiBlast_CBE
79.40
42%
-93
- C1 -
1OPK
3
ABL1_MOUSE
A:
[47-466]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
G
Y
N
H
-
N
G
E
W
C
E
A
Q
-
T
-
K
-
N
G
Q
-
G
W
V
P
S
N
Y
I
T
P
V
-
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
-
Y
L
L
S
-
S
-
G
-
I
N
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
--
R
Y
------
E
G
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
K
R
N
K
--
P
T
I
Y
--------------
G
V
SP
N
--
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
---
K
Y-----
S
--------
L
-----
T
V
A
V
K
T
L
K
E
D
T
--
M
E
---
V
--
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---------------
Q
------
E
--------
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
---
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
--
Y
T
A
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
97
PsiBlast_CBE
79.00
39%
-97
- C1 -
4LUE
4
HCK_HUMAN
B:
[11-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
-
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
-
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
-
P
G
N
-
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
---
T
V
K
H
Y
K
I
R
T
----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
W
E
K
--------------
D
--------
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
---
K
------
H
--------
T
-----
K
V
A
V
K
T
M
K
P
---------------
L
A
E
A
N
V
M
K
T
L
-
Q
-
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
-
E
---------------
G
------
S
--------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
---
V
C
K
I
A
D
F
G
L
A
R
V
I
------------------
P
I
K
W
T
A
P
E
A
I
N
F
---
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
-
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
55
PsiBlast_CBE
78.97
42%
-93
- C1 -
1OPL
2
ABL1_HUMAN
A:
[86-505]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
G
Y
N
H
-
N
G
E
W
C
E
A
Q
-
T
-
K
-
N
G
Q
-
G
W
V
P
S
N
Y
I
T
P
V
-
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
-
Y
L
L
S
-
S
-
G
-
I
N
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
--
R
Y
------
E
G
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
K
R
N
K
--
P
T
V
Y
--------------
G
V
SP
N
--
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
---
K
Y-----
S
--------
L
-----
T
V
A
V
K
T
L
K
E
D
T
--
M
E
---
V
--
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---------------
Q
------
E
--------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
---
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
--
Y
T
A
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
57
PsiBlast_CBE
78.56
42%
-93
- C1 -
2FO0
4
ABL1_HUMAN
A:
[44-463]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
G
Y
N
H
-
N
G
E
W
C
E
A
Q
-
T
-
K
-
N
G
Q
-
G
W
V
P
S
N
Y
I
T
P
V
-
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
-
Y
L
L
S
-
S
-
G
-
I
N
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
--
R
Y
------
E
G
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
K
R
N
K
--
P
T
V
Y
--------------
G
V
SP
N
--
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
---
K
Y-----
S
--------
L
-----
T
V
A
V
K
T
L
K
E
D
T
--
M
E
---
V
--
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---------------
Q
------
E
--------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
---
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
--
Y
T
A
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
102
PsiBlast_CBE
78.37
39%
-94
- C1 -
3VS6
1
HCK_HUMAN
B:
[11-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
-
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
-
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
-
P
G
N
-
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
RD
Y
D
P
R
Q
G
D
---
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
W
E
K
--------------
D
--------
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
---
K
------
H
--------
T
-----
K
V
A
V
K
T
M
K
P
G
S
--
M
S
---
V
--
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
-
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
-
E
---------------
G
------
S
--------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
---
V
C
K
I
A
D
F
G
L
A
R
V
I
-----------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
-
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
98
PsiBlast_CBE
77.83
39%
-96
- C1 -
4LUE
3
HCK_HUMAN
A:
[11-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
-
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
-
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
-
P
G
N
-
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
---
T
V
K
H
Y
K
I
R
T
----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
W
E
K
--------------
D
--------
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
---
K
------
H
--------
T
-----
K
V
A
V
K
T
M
K
P
G
S
-------------
L
A
E
A
N
V
M
K
T
L
-
Q
-
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
-
E
---------------
G
------
S
--------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
---
V
C
K
I
A
D
F
G
L
A
R
V
I
------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
-
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
100
PsiBlast_CBE
77.51
39%
-100
- C1 -
4LUD
2
HCK_HUMAN
A:
[11-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
-
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
----
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
-
P
G
N
-
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
---
T
V
K
H
Y
K
I
R
T
L
D
--
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
W
E
K
--------------
D
--------
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
---
K
------
H
--------
T
-----
K
V
A
V
K
T
M
K
P
-----
S
---
V
--
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
-
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
-
E
---------------
G
------
S
--------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
---
V
C
K
I
A
D
F
G
L
A
R
V
I
------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
-
P
E
----
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
101
PsiBlast_CBE
76.76
39%
-93
- C1 -
3VS7
1
HCK_HUMAN
B:
[11-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
-
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
-
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
-
P
G
N
-
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
---
T
V
K
H
Y
K
I
R
T
-----
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
W
E
K
--------------
D
--------
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
---
K
------
H
--------
T
-----
K
V
A
V
K
T
M
K
P
G
S
--
M
S
---
V
--
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
-
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
-
E
---------------
G
------
S
--------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
---
V
C
K
I
A
D
F
G
L
A
R
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
-
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
99
PsiBlast_CBE
75.98
39%
-94
- C1 -
4LUD
3
HCK_HUMAN
B:
[11-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
-
G
-
E
W
W
K
A
R
-
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
-
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
-
P
G
N
-
M
L
G
S
F
M
I
R
D
S
E
T
---
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
---
T
V
K
H
Y
K
I
-----------------
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
W
E
K
--------------
D
--------
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
---
K
------
H
--------
T
-----
K
V
A
V
K
T
M
K
P
G
----
S
---
V
--
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
-
H
D
K
L
V
K
L
H
A
V
V
T
K
E
--
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
-
E
---------------
G
------
S
--------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
---
V
C
K
I
A
D
F
G
L
A
R
V
I
------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
-
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
120
HHSearch
75.93
33%
-113
- C1 -
2OZO
1
ZAP70_HUMAN
A:
[155-598]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
A
H
E
R
M
P
W
Y
H
S
S
L
T
R
E
E
A
E
-
R
K
L
Y
-
S
G
A
Q
T
D
G
K
F
L
L
R
P
R
-
K
E
Q
G
T
Y
A
L
S
L
--
I
Y
------
G
K
T
V
Y
H
Y
L
I
S
Q
D
K
A
G
K
Y
C
I
P
E
G
T
K
F
D
T
L
W
Q
L
V
E
Y
L
K
L
K
A
D
G
L
I
Y
C
L
K
E
A
C
P
N
---------MDTSVFESPFSDPE
E
L
--
K
--
D
K
K
L
F
L
K
R
D
N
L
L
I
A
D
I
E
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
R
M
RK
K
------
Q
--------
I
-----
D
V
A
I
K
V
L
K
Q
G
T
EK
A
D
---
T
--
E
E
M
M
R
E
A
Q
I
M
H
Q
L
-
D
-
N
P
Y
I
V
R
L
I
G
V
C
Q
A
--
E
A
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
G
K
-
R
---------------
E
------
E
--------
I
P
-
V
S
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
N
L
A
A
R
N
V
L
L
V
N
R
H
---
Y
A
K
I
S
D
F
G
L
S
K
A
L
G
-----------------
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
K
P
Y
K
K
M
K
-
G
-
P
E
V
M
A
F
I
E
Q
G
K
R
M
E
C
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
Y
S
L
A
54
PsiBlast_CBE
74.26
42%
-101
- C1 -
1OPL
1
ABL1_HUMAN
B:
[140-505]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
-
Y
L
L
S
-
S
-
G
-
I
N
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
--
R
Y
------
E
G
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
--------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
---
K
Y-----
S
--------
L
-----
T
V
A
V
K
T
L
K
E
D
T
--
M
E
---
V
--
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---------------
Q
------
E
--------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
---
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
--
T
--
Y
T
A
H
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
--
46
PsiBlast_CBE
73.82
57%
-112
- C1 -
4M14
2
A:
[4-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
-----
K
V
A
I
K
T
I
R
E
G
A
--
M
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---------------
G
------
L
--------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
--
Q
--
Y
T
S
S
T
G
-
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
122
HHSearch
73.77
66%
-112
- C1 -
3SXS
1
A:
[1-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
M
E
L
K
R
E
E
I
T
L
L
K
-
E
L
G
S
G
Q
F
G
V
V
K
L
G
K
W
K
---
G
------
Q
--------
Y
-----
D
V
A
V
K
M
I
K
E
G
S
--
M
S
---
E
--
D
E
F
F
Q
E
A
Q
T
M
M
K
L
-
S
-
H
P
K
L
V
K
F
Y
G
V
C
S
K
E
-
Y
P
I
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
S
H
-
G
---------------
K
------
G
--------
L
E
-
P
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
D
L
---
C
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
D
--
Q
--
Y
V
S
S
V
G
-
T
K
F
P
V
K
W
S
A
P
E
V
F
H
Y
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
T
-
N
-
S
E
V
V
L
K
V
S
Q
G
H
R
L
Y
R
P
H
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
E
P
L
R
E
---
76
PsiBlast_CBE
73.70
58%
-125
- C1 -
3V5L
1
D:
[4-263]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
-
G
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
-----
K
V
A
I
K
T
I
R
--
A
--
M
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---------------
G
------
L
--------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
G
M
---------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-
28
PsiBlast_CBE
73.67
67%
-114
- C1 -
3SXS
1
A:
[1-259]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
M
E
L
K
R
E
E
I
T
L
L
K
-
E
L
G
S
G
Q
F
G
V
V
K
L
G
K
W
K
---
G
------
Q
--------
Y
-----
D
V
A
V
K
M
I
K
E
G
S
--
M
S
---
E
--
D
E
F
F
Q
E
A
Q
T
M
M
K
L
-
S
-
H
P
K
L
V
K
F
Y
G
V
C
S
K
E
-
Y
P
I
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
S
H
-
G
---------------
K
------
G
--------
L
E
-
P
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
D
L
---
C
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
D
--
Q
--
Y
V
S
S
V
G
-
T
K
F
P
V
K
W
S
A
P
E
V
F
H
Y
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
T
-
N
-
S
E
V
V
L
K
V
S
Q
G
H
R
L
Y
R
P
H
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
E
P
L
R
E
---
50
PsiBlast_CBE
73.51
57%
-109
- C1 -
4M0Y
2
A:
[5-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
-----
K
V
A
I
K
T
I
R
E
G
A
--
M
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---------------
G
------
L
--------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
--
Q
--
Y
T
S
S
T
G
-
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--
93
PsiBlast_CBE
73.49
57%
-115
- C1 -
4L7S
1
ITK_HUMAN
A:
[4-263]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
-----
K
V
A
I
K
T
I
R
E
G
A
--
M
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---------------
G
------
L
--------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
G
M
T
---------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
L
29
PsiBlast_CBE
73.48
67%
-113
- C1 -
3SXR
1
B:
[1-259]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
M
E
L
K
R
E
E
I
T
L
L
K
-
E
L
------
V
V
K
L
G
K
W
K
---
G
------
Q
--------
Y
-----
D
V
A
V
K
M
I
K
E
G
S
--
M
S
---
E
--
D
E
F
F
Q
E
A
Q
T
M
M
K
L
-
S
-
H
P
K
L
V
K
F
Y
G
V
C
S
K
E
-
Y
P
I
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
S
H
-
G
---------------
K
------
G
--------
L
E
-
P
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
D
L
---
C
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
D
--
Q
--
Y
V
S
S
V
G
-
T
K
F
P
V
K
W
S
A
P
E
V
F
H
Y
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
T
-
N
-
S
E
V
V
L
K
V
S
Q
G
H
R
L
Y
R
P
H
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
E
P
L
R
E
---
72
PsiBlast_CBE
73.45
58%
-122
- C1 -
3V8W
1
B:
[4-263]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
-----
K
V
A
I
K
T
I
R
-----
M
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---------------
G
------
L
--------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
G
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-
47
PsiBlast_CBE
73.43
57%
-113
- C1 -
4M13
1
A:
[4-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
-----
K
V
A
I
K
T
I
R
E
G
A
--
M
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---------------
G
------
L
--------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
--
Q
--
Y
T
S
S
T
G
-
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--
45
PsiBlast_CBE
73.35
57%
-111
- C1 -
4M15
2
A:
[4-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
-----
K
V
A
I
K
T
I
R
E
G
A
--
M
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---------------
G
------
L
--------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
--
Q
--
Y
T
S
S
T
G
-
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
48
PsiBlast_CBE
73.26
57%
-111
- C1 -
4M12
1
A:
[4-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
-----
K
V
A
I
K
T
I
R
E
G
A
--
M
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---------------
G
------
L
--------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
--
Q
--
Y
T
S
S
T
G
-
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--
49
PsiBlast_CBE
73.21
57%
-111
- C1 -
4M0Z
2
A:
[4-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
-----
K
V
A
I
K
T
I
R
E
G
A
--
M
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---------------
G
------
L
--------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
--
Q
--
Y
T
S
S
T
G
-
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--
51
PsiBlast_CBE
73.10
57%
-114
- C1 -
4HCV
1
A:
[5-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
-----
K
V
A
I
K
T
I
R
E
G
A
--
M
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---------------
G
------
L
--------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
--
Q
--
Y
T
S
S
T
G
-
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--
44
PsiBlast_CBE
73.05
58%
-113
- C1 -
3T9T
3
A:
[3-264]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
-----
K
V
A
I
K
T
I
R
E
G
A
--
M
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
T
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---------------
G
------
L
--------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
--
Q
--
Y
T
S
S
T
G
-
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--
20
PsiBlast_PDB
72.97
67%
-110
- C1 -
3SXR
1
BMX_HUMAN
A:
[1-259]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
M
E
L
K
R
E
E
I
T
L
L
K
-
E
L
G
S
----
V
V
K
L
G
K
W
K
---
G
------
Q
--------
Y
-----
D
V
A
V
K
M
I
K
E
G
S
--
M
S
---
E
--
D
E
F
F
Q
E
A
Q
T
M
M
K
L
-
S
-
H
P
K
L
V
K
F
Y
G
V
C
S
K
E
-
Y
P
I
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
S
H
-
G
---------------
K
------
G
--------
L
E
-
P
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
D
L
---
C
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
D
--
Q
--
Y
V
S
S
V
G
-
T
K
F
P
V
K
W
S
A
P
E
V
F
H
Y
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
T
-
N
-
S
E
V
V
L
K
V
S
Q
G
H
R
L
Y
R
P
H
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
E
P
L
R
E
---
123
HHSearch
72.94
58%
-112
- C1 -
4HCU
1
A:
[5-267]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
-----
K
V
A
I
K
T
I
R
E
G
A
--
M
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---------------
G
------
L
--------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
--
Q
--
Y
T
S
S
T
G
-
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--
88
PsiBlast_CBE
72.89
57%
-119
- C1 -
4PP9
1
B:
[4-263]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
-----
K
V
A
I
K
T
I
R
E
G
A
--
M
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---------------
G
------
L
--------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
G
M
----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-
89
PsiBlast_CBE
72.84
57%
-115
- C1 -
4PP9
1
ITK_HUMAN
A:
[4-263]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
-----
K
V
A
I
K
T
I
R
E
G
A
--
M
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---------------
G
------
L
--------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
G
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-
61
PsiBlast_CBE
72.84
59%
-116
- C1 -
3QGW
1
ITK_HUMAN
A:
[24-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
-----
K
V
A
I
K
T
I
K
E
G
S
--
M
S
---
E
--
D
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---------------
G
------
L
--------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
G
----------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--
52
PsiBlast_CBE
72.84
57%
-112
- C1 -
4HCU
1
A:
[5-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
-----
K
V
A
I
K
T
I
R
E
G
A
--
M
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---------------
G
------
L
--------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
--
Q
--
Y
T
S
S
T
G
-
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--
73
PsiBlast_CBE
72.76
58%
-124
- C1 -
3V8W
1
ITK_HUMAN
A:
[4-263]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
-----
K
V
A
I
K
T
I
R
-
G
A
--
M
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---------------
G
------
L
--------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
G
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
-
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-
79
PsiBlast_CBE
72.63
58%
-125
- C1 -
3V5J
1
B:
[4-263]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
-----
K
V
A
I
K
T
I
------
M
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---------------
G
------
L
--------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
L
53
PsiBlast_CBE
72.36
57%
-112
- C1 -
4HCT
1
A:
[3-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
W
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
-----
K
V
A
I
K
T
I
R
E
G
A
--
M
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---------------
G
------
L
--------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
--
Q
--
Y
T
S
S
T
G
-
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--
92
PsiBlast_CBE
72.33
57%
-117
- C1 -
4L7S
1
B:
[4-263]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
-----
K
V
A
I
K
T
I
R
E
G
A
--
M
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---------------
G
------
L
--------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
G
M
T
---------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
L
94
PsiBlast_CBE
72.29
57%
-121
- C1 -
4KIO
3
ITK_HUMAN
C:
[4-263]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
-----
K
V
A
I
K
T
I
R
E
G
A
--
M
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---------------
G
------
L
--------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
G
M
T
--------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
L
59
PsiBlast_CBE
72.28
59%
-115
- C1 -
3QGY
1
ITK_HUMAN
A:
[24-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
-----
K
V
A
I
K
T
I
K
E
G
S
--
M
S
---
E
--
D
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---------------
G
------
L
--------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
G
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--
95
PsiBlast_CBE
72.22
57%
-125
- C1 -
4KIO
2
ITK_HUMAN
B:
[4-263]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
---
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
-----
K
V
A
I
K
T
I
--------------
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---------------
G
------
L
--------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
G
M
T
---------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-
96
PsiBlast_CBE
72.16
57%
-122
- C1 -
4KIO
2
ITK_HUMAN
A:
[4-263]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
---
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
-----
K
V
A
I
K
T
I
-----------
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---------------
G
------
L
--------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
G
M
T
---------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-
80
PsiBlast_CBE
72.06
58%
-122
- C1 -
3V5J
1
ITK_HUMAN
A:
[4-263]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
-
G
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
-----
K
V
A
I
K
T
I
R
E
G
----
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---------------
G
------
L
--------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
G
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
-
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
-
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--
58
PsiBlast_CBE
72.06
59%
-110
- C1 -
3QGY
1
B:
[24-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
-----
K
V
A
I
K
T
I
K
E
G
S
--
M
S
---
E
--
D
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---------------
G
------
L
--------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
G
M
T
---------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
----
74
PsiBlast_CBE
71.89
58%
-121
- C1 -
3V8T
1
B:
[4-263]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
-----
K
V
A
I
K
T
I
---
A
--
M
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---------------
G
------
L
--------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
G
M
T
---------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-
71
PsiBlast_CBE
71.81
58%
-114
- C1 -
1SM2
1
ITK_HUMAN
A:
[2-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
-----
K
V
A
I
K
T
I
R
E
G
A
--
M
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---------------
G
------
L
--------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
G
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-
77
PsiBlast_CBE
71.79
58%
-123
- C1 -
3V5L
1
ITK_HUMAN
C:
[4-262]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
---
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
-----
K
V
A
I
K
T
I
R
E
G
A
--
M
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---------------
G
------
L
--------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
G
M
T
--------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
----
65
PsiBlast_CBE
71.51
58%
-119
- C1 -
4MF1
1
ITK_HUMAN
A:
[4-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
-----
K
V
A
I
K
T
I
---
A
--
M
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---------------
G
------
L
--------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
G
M
----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
A
A
S
G
-
69
PsiBlast_CBE
71.36
58%
-110
- C1 -
1SNU
1
ITK_HUMAN
A:
[2-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
-----
K
V
A
I
K
T
I
R
E
G
A
--
M
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---------------
G
------
L
--------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
G
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-
60
PsiBlast_CBE
71.33
59%
-112
- C1 -
3QGW
1
B:
[24-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
-----
K
V
A
I
K
T
I
K
E
G
S
--
M
S
---
E
--
D
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---------------
G
------
L
--------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
----
68
PsiBlast_CBE
71.23
58%
-113
- C1 -
1SNU
1
B:
[2-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
-----
K
V
A
I
K
T
I
R
E
G
A
--
M
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---------------
G
------
L
--------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
66
PsiBlast_CBE
71.18
58%
-110
- C1 -
3MJ2
1
A:
[4-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
-----
K
V
A
I
K
T
I
R
E
G
A
--
M
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---------------
G
------
L
--------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
--
Q
--
Y
T
S
S
T
G
-
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
-----
75
PsiBlast_CBE
71.07
58%
-123
- C1 -
3V8T
1
ITK_HUMAN
A:
[4-263]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
---
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
-----
K
V
A
I
K
T
I
R
E
G
A
--
M
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---------------
G
------
L
--------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
G
M
----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
--------
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--
67
PsiBlast_CBE
71.07
58%
-121
- C1 -
3MJ1
1
A:
[4-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
-----
K
V
A
I
K
T
I
------------------
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---------------
G
------
L
--------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
-
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
-----
62
PsiBlast_CBE
71.06
58%
-119
- C1 -
4RFM
1
A:
[4-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
-----
K
V
A
I
K
T
I
R
E
G
A
--
M
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---------------
G
------
L
--------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
G
M
T
R
-------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
A
A
S
--
78
PsiBlast_CBE
71.02
58%
-120
- C1 -
3V5L
1
ITK_HUMAN
A:
[4-262]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
-----
K
V
A
I
K
T
I
------
M
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---------------
G
------
L
--------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
G
M
T
---------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
----
64
PsiBlast_CBE
70.97
58%
-119
- C1 -
4MF1
1
B:
[4-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
-----
K
V
A
I
K
T
I
---
A
--
M
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---------------
G
------
L
--------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
G
M
T
R
-------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
A
A
S
G
-
70
PsiBlast_CBE
70.85
58%
-115
- C1 -
1SM2
1
B:
[2-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
-----
K
V
A
I
K
T
I
R
E
G
A
--
M
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---------------
G
------
L
--------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---
63
PsiBlast_CBE
70.51
58%
-114
- C1 -
4PQN
2
A:
[4-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
-----
K
V
A
I
K
T
I
R
E
G
A
--
M
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---------------
G
------
L
--------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
G
----------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
-----
83
PsiBlast_CBE
67.24
57%
-122
- C1 -
4PPC
2
ITK_HUMAN
A:
[4-263]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
-----
K
V
A
I
K
T
I
-----------------
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---------------
G
------
L
--------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-
87
PsiBlast_CBE
66.97
57%
-123
- C1 -
4PPA
2
ITK_HUMAN
A:
[4-263]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
-----
K
V
A
I
K
T
I
--------------
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---------------
G
------
L
--------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
G
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-
86
PsiBlast_CBE
66.96
57%
-120
- C1 -
4PPA
2
B:
[4-263]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
-----
K
V
A
I
K
T
I
--------------
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---------------
G
------
L
--------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
G
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-
81
PsiBlast_CBE
66.80
57%
-114
- C1 -
4QD6
2
B:
[4-263]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
-----
K
V
A
I
K
T
I
-----------
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---------------
G
------
L
--------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
G
M
T
---------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-
82
PsiBlast_CBE
66.67
57%
-121
- C1 -
4PPC
2
B:
[4-263]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
-----
K
V
A
I
K
T
I
-----------------
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
---
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---------------
G
------
L
--------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-
128
HHSearch
66.06
36%
-97
- C1 -
1T46
1
?
A:
[16-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
W
E
F
P
R
N
R
L
S
F
G
K
-
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
---
G
LIKSD
A
A
--------
M
-----
T
V
A
V
K
M
L
K
P
S
A
--
H
L
T
E
-
R
--
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
-
H
M
N
I
V
N
L
L
G
A
C
T
I
G
-
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
-
R
---------------
D
SFL---
A
--------
L
D
-
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
H
G
R
---
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
--
S
N-
Y
V
V
K
G
N
-
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
-
V
D
S
K
F
Y
K
M
I
K
E
G
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
S
T
130
HHSearch
65.97
38%
-104
* C1 *
4AOJ
1
NTRK1_HUMAN
A:
[35-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
H
I
K
R
R
D
I
V
L
K
W
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
---
N
LLP---
K
--------
M
-----
L
V
A
V
K
A
L
K
E
A
S
--
E
S
A
--
R
--
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
-
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
-
G
PDP------------
G
------
P
--------
L
G
-
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
---
V
V
K
I
G
D
F
G
--------------------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
-
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
90
PsiBlast_CBE
65.57
57%
-117
- C1 -
4MF0
2
B:
[4-263]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
---
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
-----
K
V
A
I
K
T
I
------
M
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---------------
G
------
L
--------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-
85
PsiBlast_CBE
65.57
57%
-118
- C1 -
4PPB
2
ITK_HUMAN
A:
[4-263]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
-----
K
V
A
I
K
T
I
--------------
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---------------
G
------
L
--------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
G
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-
104
Fugue
65.54
45%
-114
- C1 -
1BYG
1
CSK_HUMAN
A:
[15-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
W
A
L
N
M
K
E
L
K
L
L
Q
-
T
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
R
---
G
---------------
N
-----
K
V
A
V
K
C
I
K
-----
N
D
---
A
--
Q
A
F
L
A
E
A
S
V
M
T
Q
L
-
R
-
H
S
N
L
V
Q
L
L
G
V
I
V
--E
E
G
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
S
R
-
G
R--------------
S
------
V
--------
L
G
-
G
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
E
D
N
---
V
A
K
V
S
D
F
G
---------------------
L
L
P
V
K
W
T
A
P
E
A
L
R
E
K
K
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
R
V
P
Y
P
R
I
P
L--
K
D
V
V
P
R
V
E
K
G
Y
K
M
D
A
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
E
H
I
K
T
H
E
L
91
PsiBlast_CBE
65.43
57%
-113
- C1 -
4MF0
2
ITK_HUMAN
A:
[4-263]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
---
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
-----
K
V
A
I
K
T
I
------
M
S
---
E
--
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---------------
G
------
L
--------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
G
M
T
---------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-
84
PsiBlast_CBE
65.02
57%
-118
- C1 -
4PPB
2
B:
[4-263]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
---
N
------
K
--------
D
-----
K
V
A
I
K
T
I
--------------
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
-
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---------------
G
------
L
--------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
---
V
I
K
V
S
D
F
G
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-
132
HHSearch
64.95
35%
-99
- C1 -
3TT0
1
FGFR1_HUMAN
A:
[54-353]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
--
E
L
P
E
-----------------------
D
P
R
W
E
L
P
R
D
R
L
V
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
---
G
------
L
DKDKPN
R
V
T
-----
K
V
A
V
K
M
L
K
S
D
A
--
T
E
---
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
PPGLEYSYNPSHNP
E
E
------
Q
--------
L
S
-
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
---
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
--
D
Y-
Y
K
K
T
T
N
-
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
-
V
-
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
134
HHSearch
64.92
39%
-107
- C1 -
3KUL
2
EPHA8_HUMAN
A:
[43-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
E
I
E
A
S
R
I
H
I
E
K
-
I
I
G
S
G
D
S
G
E
V
C
Y
G
R
L
R
---
V
PG----
Q
R
D
------
V
-----
P
V
A
I
K
A
L
K
A
G
Y
--
T
E
R
Q
-
R
--
R
D
F
L
S
E
A
S
I
M
G
Q
F
-
D
-
H
P
N
I
I
R
L
E
G
V
V
T
R
G
-
R
L
A
M
I
V
T
E
Y
M
E
N
G
S
L
D
T
F
L
R
T
H
-
D
---------------
G
------
Q
--------
F
T
-
I
M
Q
L
V
G
M
L
R
G
V
G
A
G
M
R
Y
L
S
D
L
G
Y
V
H
R
D
L
A
A
R
N
V
L
V
D
S
N
L
---
V
C
K
V
S
D
F
G
L
S
R
V
L
E
-----A-
A
Y
T
T
T
----
I
P
I
R
W
T
A
P
E
A
I
A
F
R
T
F
S
S
A
S
D
V
W
S
F
G
V
V
M
W
E
V
L
A
Y
G
E
R
P
Y
W
N
M
T
-
N
-
R
D
V
I
S
S
V
E
E
G
Y
R
L
P
A
P
M
G
C
P
H
A
L
H
Q
L
M
L
D
C
W
H
K
D
R
A
Q
R
P
R
F
S
Q
I
V
S
V
L
D
A
L
I
R
S
P
E
133
HHSearch
64.63
37%
-108
- C1 -
4FYO
1
A:
[11-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
Q
---
M
------
K
K
V
V
-----
K
-----
T
V
A
V
K
I
L
--------P
A
L
K
--
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
-
N
P
Y
I
V
R
M
I
G
I
C
E
A
E
--
S
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
N
-----------------
R
------
H
--------
V
K
-
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
---
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
--
E
NY
Y
K
A
-----
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
-
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
V
129
HHSearch
64.58
38%
-88
- C1 -
4CLJ
1
A:
[10-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
C
F
A
G
K
T
S
--------------
S
I
--
S
---
D
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
--------------------P
L
---
Q
V
A
V
K
T
L
P
E
V
C
--
S
E
Q
D
-
E
--
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
-
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
-
R
---------------
P
RPSQPS
S
--------
L
A
-
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
PG
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
----------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
-
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
127
HHSearch
64.35
36%
-106
- C1 -
1U59
1
A:
[3-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
F
L
K
R
D
N
L
L
I
A
D
I
E
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
R
---
K
------
Q
--------
I
-----
D
V
A
I
K
V
L
K
Q
G
T
--
E
K
A
D
-
T
--
E
E
M
M
R
E
A
Q
I
M
H
Q
L
-
D
-
N
P
Y
I
V
R
L
I
G
V
C
Q
A
E
--
A
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
G
K
-
R
---------------
E
------
E
--------
I
P
-
V
S
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
N
R
H
---
Y
A
K
I
S
D
F
G
L
S
K
A
L
G
A
D
D
S
Y
--
Y
T
A
R
S
A
-
G
K
W
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
K
P
Y
K
K
M
K
-
G
-
P
E
V
M
A
F
I
E
Q
G
K
R
M
E
C
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
Y
S
L
A
131
HHSearch
62.81
31%
-101
- C1 -
4OTW
1
A:
[7-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
I
F
K
E
T
E
L
R
K
L
K
-
V
L
G
S
G
V
F
G
T
V
H
K
G
V
W
I
---
P
------
E
--------
G
ES
I
K
I
P
V
C
I
K
V
I
E
D
K
S
GR
Q
S
---
F
--
Q
A
V
T
D
H
M
L
A
I
G
S
L
-
D
-
H
A
H
I
V
R
L
L
G
L
C
P
G
S
--
S
L
Q
L
V
T
Q
Y
L
P
L
G
S
L
L
D
H
V
R
Q
H
-
R
---------------
G
------
A
--------
L
G
-
P
Q
L
L
L
N
W
G
V
Q
I
A
K
G
M
Y
Y
L
E
E
H
G
M
V
H
R
N
L
A
A
R
N
V
L
L
K
S
P
S
---
Q
V
Q
V
A
D
F
G
V
A
D
L
L
P
P
D
-------------
K
T
P
I
K
W
M
A
L
E
S
I
H
F
G
K
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
E
P
Y
A
G
L
R
-
L
-
A
E
V
P
D
L
L
E
K
G
E
R
L
A
Q
P
Q
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
E
N
I
R
P
T
F
K
E
L
A
N
E
F
T
R
M
A
R
D
P
P
135
HHSearch
62.71
35%
-102
- C1 -
2XIR
1
A:
[20-311]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
W
E
F
P
R
D
R
L
K
L
G
K
-
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
---
G
------
I
DKTA
T
C
--
R
-----
T
V
A
V
K
M
L
K
E
G
A
--
T
H
---
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
-
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
---------------
N
------
E
FVPYYKD
F
L
T
-
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
---
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P-
D
--
Y
V
R
K
G
D
-
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
-
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A