@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CDK15_HUMAN: (2015-10-04 )
MGQELCAKTVQPGCSCYHCSEGGEAHSCRRSQPETTEAAFKLTDLKEASCSMTSFHPRGLQAARAQKFKSKRPRSNSDCFQEEDLRQGFQWRKSLPFGAASSYLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAEEGVPFTAIREASLLKGLKHANIVLLHDIIHTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLPTPRSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQEALVHDYFSALPSQLYQLPDEESLFTVSGVRLKPEMCDLLASYQKGHHPAQFSKCW
Atome Classification :
(92 SA)
.........10........20........30........40........50........60........70........80........90......-..100.......110.......120.--......130......-.-140.......150.......160.......--170----.-........180.......190--.-----.-......200.......210.......220.......230----.-.-.....240.......250........260.......270.......280.......290...-....300....----...310.......320.......330.......---340---........350..--..--.-.---.360.......370.......380.......390.......400.......410.......420.......430...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
G
Q
E
L
C
A
K
TVQPG
C
S
C
Y
HCSEGGEAHSCRRSQPETTE
A
A
F
K
LTDLKEASCSMTSFHPRG
L
Q
A
A
R
A
Q
K
F
K
SKRPRSNSDCF
Q
E
E
D
L
R
Q
G
F
Q
W
R
KSLPF-GA
A
S
S
Y
L
N
L
E
K
LGEG
S
Y
A
T
V
Y
K
G
I
S
R
--IN
G
Q
L
V
A
L
K
V
I
SMNA-E-EGV
P
F
T
A
I
R
E
A
S
L
L
K
GLKHA
N
I
V
L
L
H
D
I
IH--
T
------
K
-
E
T
L
T
F
V
F
E
Y
M
H
T
D
L
A
Q
Y
M
S
Q---H-----P-GGLHP
H
N
V
R
L
F
M
F
Q
L
L
R
G
L
A
Y
I
H
H
Q
H
V
L
H
RDLK
P
Q
N
L
L
I
----
S
-
H
-
L
GEL
K
L
A
D
FG
L
A
R
A
KSI-PSQTYSS
E
V
V
T
L
W
YR
P
P
D
A
LLGATEYSSELDIWGA
G
C
I
F
I
E
MFQ-GQPLFP
G
V
S
N
I
----
L
E
Q
L
E
K
I
W
E
V
LGVPTEDTWPG
V
S
KLPNYNPEWF---PL----PTPR
S
L
H
V
V
W
N
RL--GR--V-P---
E
A
E
D
L
A
S
Q
M
L
KGFPRDR
V
S
A
Q
E
A
L
V
H
D
Y
F
S
A
L
P
S
Q
L
YQLPDEE
S
L
F
T
VSG
V
R
L
K
P
E
M
C
D
L
L
A
S
Y
QKGHHPAQFSKCW
8
PsiBlast_PDB
91.08
52%
-115
- C1 -
1UNL
1
CDK5_HUMAN
A:
[4-287]
-------------------------------------------------------------------------------------------------------
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
--
E
T
H
E
I
V
A
L
K
R
V
R
L
D
D
-
D
D
E
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
H
--
S
------
D
-
K
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
-----
N
-
G
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
R
-
N
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
-
P
V
R
C
Y
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
-
N
D
V
----
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
P
--
Y
---
P
M
Y---
P
A
T
T
S
L
V
N
V
V
P
K
L
--
N
A
--
T
------
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
F
C
P
P
------------------------------------------
4
PsiBlast_PDB
90.34
51%
-106
- C1 -
4KRC
1
PHO85_YEAST
A:
[2-298]
--------------------------------------------------------------------------------------------------
S
S
S
S
Q
F
K
Q
L
E
K
L
G
N
G
T
Y
A
T
V
Y
K
G
L
N
K
--
T
T
G
V
Y
V
A
L
K
E
V
K
L
D
S
-
E
-
E
G
T
P
S
T
A
I
R
E
I
S
L
M
K
E
L
K
H
E
N
I
V
R
L
Y
D
V
I
H
--
T
------
E
-
N
K
L
T
L
V
F
E
F
M
D
N
D
L
K
K
Y
M
D
S
---
R
T----
P
-
R
G
L
E
L
N
L
V
K
Y
F
Q
W
Q
L
L
Q
G
L
A
F
C
H
E
N
K
I
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
K
-
R
G
Q
L
K
L
G
D
F
G
L
A
R
A
F
G
I
-
P
V
N
T
F
S
S
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
R
T
Y
S
T
S
I
D
I
W
S
C
G
C
I
L
A
E
M
I
T
-
G
K
P
L
F
P
G
-
T
N
D
----
E
E
Q
L
K
L
I
F
D
I
M
G
T
P
N
E
S
L
W
P
S
V
T
K
L
P
K
Y
N
P
N
I
Q
---
Q
R
----
P
-
P
R
D
L
R
Q
V
L
Q
P
H
--
T
K
--
E
-
P
L
D
G
N
L
M
D
F
L
H
G
L
L
Q
L
N
P
D
M
R
L
S
A
K
Q
A
L
H
H
P
W
F
A
E
Y
Y
H
-------------------------------------------
11
PsiBlast_PDB
89.65
48%
-110
- C1 -
3NIZ
1
?
A:
[15-311]
-----------------------------------------------------------------------------------------------
Y
F
Q
G
L
M
E
K
Y
Q
K
L
E
K
V
G
E
G
T
Y
G
V
V
Y
K
A
K
D
S
---
Q
G
R
I
V
A
L
K
R
I
R
-------
G
I
P
S
T
A
I
R
E
I
S
L
L
K
E
L
H
H
P
N
I
V
S
L
I
D
V
I
H
--
S
------
E
-
R
C
L
T
L
V
F
E
F
M
E
K
D
L
K
K
V
L
D
E
---
N
-----
K
-
T
G
L
Q
D
S
Q
I
K
I
Y
L
Y
Q
L
L
R
G
V
A
H
C
H
Q
H
R
I
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
S
-
D
G
A
L
K
L
A
D
F
G
L
A
R
A
F
G
I
-
P
V
R
---
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
S
V
D
I
W
S
I
G
C
I
F
A
E
M
I
T
-
G
K
P
L
F
P
G
V
T
D
D
-----
D
Q
L
P
K
I
F
S
I
L
G
T
P
N
P
R
E
W
P
Q
V
Q
E
L
P
L
W
K
Q
R
T
F
---
Q
V
----
F
E
K
K
P
----
W
S
S
I
I
P
G
F
--
C
-
Q
---
E
G
I
D
L
L
S
N
M
L
C
F
D
P
N
K
R
I
S
A
R
D
A
M
N
H
P
Y
F
K
D
L
D
P
Q
I
-----------------------------------------
23
PsiBlast_CBE
89.61
51%
-117
- C1 -
4AU8
2
CDK5_HUMAN
B:
[6-291]
-----------------------------------------------------------------------------------------------------
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
--
E
T
H
E
I
V
A
L
K
R
V
R
L
-----
E
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
H
--
S
--------
K
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
-----
N
-
G
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
R
-
N
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
I
-
P
V
------
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
-
N
D
V
----
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
P
--
Y
---
P
M
Y
---
P
A
T
T
S
L
V
N
V
V
P
K
L
--
N
A
--
T
------
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
F
---------------------------------------------
20
PsiBlast_PDB
89.38
49%
-111
- C1 -
1H1R
1
CDK2_HUMAN
A:
[5-291]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
-
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
--------------------------------------
6
PsiBlast_PDB
88.87
51%
-111
- C1 -
4AU8
2
CDK5_HUMAN
A:
[4-291]
---------------------------------------------------------------------------------------------------
G
S
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
--
E
T
H
E
I
V
A
L
K
R
V
----------
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
H
------------
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
-----
N
-
G
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
R
-
N
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
I
-
P
V
R
--
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
-
N
D
V
----
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
P
--
Y
---
P
M
Y---
P
A
T
T
S
L
V
N
V
V
P
K
L
--
N
A
--
T
------
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
F
---------------------------------------------
86
PsiBlast_CBE
88.80
49%
-116
- C1 -
3FZ1
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
18
PsiBlast_PDB
88.58
49%
-112
- C1 -
1H1P
1
CDK2_HUMAN
A:
[5-291]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
-
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
--------------------------------------
80
PsiBlast_CBE
88.55
49%
-114
- C1 -
3NS9
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
--------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
83
PsiBlast_CBE
88.51
49%
-120
- C1 -
3LFN
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
----------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
24
PsiBlast_CBE
88.50
52%
-116
- C1 -
3O0G
1
CDK5_HUMAN
B:
[6-287]
---------------------------------------------------------------------------------------------------------
K
L
E
K
I
G
-----
T
V
F
K
A
--------
E
I
V
A
L
K
R
V
R
---------
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
H
--
S
------
D
-
K
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
-----
N
-
G
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
R
-
N
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
-
P
V
R
C
Y
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
-
N
D
V
----
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
P
--
Y
---
P
M
Y---
P
A
T
T
S
L
V
N
V
V
P
K
L
--
N
A
--
T
------
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
----------------------------------------------
116
HHSearch
88.46
49%
-112
- C1 -
3NIZ
1
?
A:
[21-311]
-----------------------------------------------------------------------------------------------------
E
K
Y
Q
K
L
E
K
V
G
E
G
T
Y
G
V
V
Y
K
A
K
D
---
S
Q
G
R
I
V
A
L
K
R
I
R
-------
G
I
P
S
T
A
I
R
E
I
S
L
L
K
E
L
H
H
P
N
I
V
S
L
I
D
V
I
H
--
S
------
E
-
R
C
L
T
L
V
F
E
F
M
E
K
D
L
K
K
V
L
D
E
---
N
-----
K
-
T
G
L
Q
D
S
Q
I
K
I
Y
L
Y
Q
L
L
R
G
V
A
H
C
H
Q
H
R
I
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
S
-
D
G
A
L
K
L
A
D
F
G
L
A
R
A
F
G
I
-
P
V
R
---
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
S
V
D
I
W
S
I
G
C
I
F
A
E
M
I
T
-
G
K
P
L
F
P
G
V
T
D
-----
D
D
Q
L
P
K
I
F
S
I
L
G
T
P
N
P
R
E
W
P
Q
V
Q
E
L
P
L
W
K
Q
R
T
F
---
Q
V
----
F
E
K
K
P
W
S
S
I
I
P
G
F
------
C
-
Q
---
E
G
I
D
L
L
S
N
M
L
C
F
D
P
N
K
R
I
S
A
R
D
A
M
N
H
P
Y
F
K
D
L
D
P
Q
I
-----------------------------------------
39
PsiBlast_CBE
88.43
48%
-112
- C1 -
2C4G
1
CDK2_HUMAN
A:
[2-291]
-----------------------------------------------------------------------------------------------
P
L
-
V
D
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
-
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
-------------------------------------
16
PsiBlast_PDB
88.38
50%
-111
- C1 -
1V0P
1
CDC2H_PLAFK
A:
[3-285]
------------------------------------------------------------------------------------------------------
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
N
--
Y
-
G
E
T
F
A
L
K
K
I
R
L
E
K
-
E
D
E
G
I
P
S
T
T
I
R
E
I
S
I
L
K
E
L
K
H
S
N
I
V
K
L
Y
D
V
I
H
--
T
------
K
-
K
R
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
V
---
C
-----
E
-
G
G
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
R
-
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
G
----------
I
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
-
G
T
P
L
F
P
G
V
S
E
A
-----
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
E
L
P
K
Y
D
P
N
F
T
V
Y
E
P
L
----
P
W
E
S
F
L
K
--------
G
L
--
D
-
E
---
S
G
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
K
E
----------------------------------------------
96
PsiBlast_CBE
88.28
49%
-112
- C1 -
2X1N
1
CDK2_HUMAN
C:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
-
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
-------------------------------------
50
PsiBlast_CBE
88.16
49%
-112
- C1 -
4KD1
2
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
-
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
93
PsiBlast_CBE
88.04
49%
-115
- C1 -
3EID
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
--
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
-------------------------------------
68
PsiBlast_CBE
88.02
49%
-122
- C1 -
4BGH
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
32
PsiBlast_CBE
87.94
48%
-115
- C1 -
2WPA
1
CDK2_HUMAN
C:
[5-291]
---------------------------------------------------------------------------------------------------
D
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
-
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
48
PsiBlast_CBE
87.92
49%
-113
- C1 -
5A14
2
?
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
---T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
--------------------------------------
29
PsiBlast_CBE
87.72
49%
-121
- C1 -
3EZR
2
CDK2_HUMAN
A:
[3-288]
----------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
-------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
19
PsiBlast_PDB
87.72
49%
-111
- C1 -
1H1Q
1
CDK2_HUMAN
A:
[5-291]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
-
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
--------------------------------------
69
PsiBlast_CBE
87.69
49%
-115
- C1 -
3WBL
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
---
T
G
E
V
V
A
L
K
K
I
R
L
------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
35
PsiBlast_CBE
87.57
48%
-110
- C1 -
2WIP
1
CDK2_HUMAN
A:
[2-291]
-----------------------------------------------------------------------------------------------
P
L
-
V
D
M
E
N
F
Q
K
V
E
K
I
G
-----
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
-
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
33
PsiBlast_CBE
87.55
48%
-108
- C1 -
2WPA
1
CDK2_HUMAN
A:
[2-291]
-----------------------------------------------------------------------------------------------
P
L
-
V
D
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
-
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
43
PsiBlast_CBE
87.36
48%
-113
- C1 -
2BKZ
1
CDK2_HUMAN
A:
[2-291]
-----------------------------------------------------------------------------------------------
P
L
-
V
D
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
-
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
73
PsiBlast_CBE
87.34
49%
-112
- C1 -
3TIZ
9
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
17
PsiBlast_PDB
87.31
49%
-113
- C1 -
4EOQ
1
CDK2_HUMAN
A:
[3-290]
--------------------------------------------------------------------------------------------------
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
-------------------------------------
82
PsiBlast_CBE
87.29
49%
-114
- C1 -
3LFQ
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
28
PsiBlast_CBE
87.20
49%
-117
- C1 -
3EZV
1
CDK2_HUMAN
A:
[3-288]
----------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
79
PsiBlast_CBE
87.16
49%
-118
- C1 -
3PJ8
1
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
94
PsiBlast_CBE
87.15
49%
-113
- C1 -
2XNB
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
---T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
30
PsiBlast_CBE
87.02
48%
-114
- C1 -
2WXV
1
CDK2_HUMAN
C:
[5-291]
---------------------------------------------------------------------------------------------------
D
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
-
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
42
PsiBlast_CBE
87.01
48%
-113
- C1 -
2BKZ
1
CDK2_HUMAN
C:
[5-291]
---------------------------------------------------------------------------------------------------
D
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
-
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
-------------------------------------
99
PsiBlast_CBE
86.99
49%
-111
- C1 -
2WEV
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
-
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
--------------------------------------
72
PsiBlast_CBE
86.88
49%
-119
- C1 -
3ULI
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
--------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
37
PsiBlast_CBE
86.88
48%
-110
- C1 -
2WIH
1
CDK2_HUMAN
A:
[2-291]
-----------------------------------------------------------------------------------------------
P
L
-
V
D
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
-
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
51
PsiBlast_CBE
86.74
49%
-110
- C1 -
4FX3
1
CDK2_HUMAN
C:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
-
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
49
PsiBlast_CBE
86.72
49%
-110
- C1 -
4LYN
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
-
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
107
HHSearch
86.70
52%
-104
- C1 -
4AU8
2
CDK5_HUMAN
A:
[6-293]
-----------------------------------------------------------------------------------------------------
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
--
E
T
H
E
I
V
A
L
K
R
V
----------
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
H
------------
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
-----
N
-
G
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
R
-
N
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
I
-
P
V
R
--
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
-
D
V
----
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
P
Y
P
M
---
Y
P
----
A
T
T
S
----
L
V
N
V
V
--
P
K
--
L
-
N
A
--
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
F
---------------------------------------------
38
PsiBlast_CBE
86.70
48%
-115
- C1 -
2C4G
1
CDK2_HUMAN
C:
[4-291]
--------------------------------------------------------------------------------------------------
V
D
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
-
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
95
PsiBlast_CBE
86.68
49%
-112
- C1 -
2XMY
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
41
PsiBlast_CBE
86.66
48%
-112
- C1 -
2BPM
1
CDK2_HUMAN
A:
[2-291]
-----------------------------------------------------------------------------------------------
P
L
-
V
D
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
-
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
34
PsiBlast_CBE
86.66
48%
-112
- C1 -
2WIP
1
CDK2_HUMAN
C:
[5-291]
---------------------------------------------------------------------------------------------------
D
M
E
N
F
Q
K
V
E
K
I
G
-----
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
-
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
--------------------------------------
44
PsiBlast_CBE
86.63
48%
-114
- C1 -
1VYW
1
CDK2_HUMAN
C:
[5-291]
---------------------------------------------------------------------------------------------------
D
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
-
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
67
PsiBlast_CBE
86.57
49%
-120
- C1 -
4BZD
1
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
-
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
87
PsiBlast_CBE
86.52
49%
-110
- C1 -
3F5X
2
CDK2_HUMAN
C:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
-
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
81
PsiBlast_CBE
86.50
49%
-115
- C1 -
3LFS
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
91
PsiBlast_CBE
86.48
49%
-108
- C1 -
3EJ1
1
CDK2_HUMAN
C:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
-------------------------------------
89
PsiBlast_CBE
86.39
49%
-113
- C1 -
3EOC
1
CDK2_HUMAN
C:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
--------------------------------------
74
PsiBlast_CBE
86.31
49%
-115
- C1 -
3TIY
12
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
78
PsiBlast_CBE
86.22
49%
-118
- C1 -
3S2P
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
100
PsiBlast_CBE
86.17
49%
-112
- C1 -
2W1H
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
92
PsiBlast_CBE
86.10
49%
-113
* C1 *
3EJ1
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
98
PsiBlast_CBE
86.08
49%
-110
- C1 -
2WEV
1
CDK2_HUMAN
C:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
-
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
-------------------------------------
36
PsiBlast_CBE
86.05
48%
-112
- C1 -
2WIH
1
CDK2_HUMAN
C:
[5-291]
---------------------------------------------------------------------------------------------------
D
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
-
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
90
PsiBlast_CBE
86.03
49%
-111
- C1 -
3EOC
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
45
PsiBlast_CBE
86.01
48%
-111
- C1 -
1VYW
1
CDK2_HUMAN
A:
[2-291]
-----------------------------------------------------------------------------------------------
P
L
-
V
D
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
-
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
31
PsiBlast_CBE
85.94
48%
-108
- C1 -
2WXV
1
CDK2_HUMAN
A:
[2-291]
-----------------------------------------------------------------------------------------------
P
L
-
V
D
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
-
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
71
PsiBlast_CBE
85.67
49%
-114
- C1 -
3UNJ
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
88
PsiBlast_CBE
85.62
49%
-113
- C1 -
3F5X
2
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
-
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
-
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
40
PsiBlast_CBE
85.60
48%
-112
- C1 -
2BPM
1
CDK2_HUMAN
C:
[5-291]
---------------------------------------------------------------------------------------------------
D
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
-
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
70
PsiBlast_CBE
85.56
49%
-108
- C1 -
3UNK
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
27
PsiBlast_CBE
85.53
50%
-112
- C1 -
1V0P
1
CDC2H_PLAFK
B:
[3-285]
------------------------------------------------------------------------------------------------------
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
N
--
Y
-
G
E
T
F
A
L
K
------------
P
S
T
T
I
R
E
I
S
I
L
K
E
L
K
H
S
N
I
V
K
L
Y
D
V
I
H
--
T
----------
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
V
---
C
-----
E
-
G
G
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
R
-
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
--------------
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
-
G
T
P
L
F
P
G
V
S
E
A
-----
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
E
L
P
K
Y
D
P
N
F
T
VYE
P
L
----
P
W
E
S
F
L
K
--------
G
L
--
D
-
E
---
S
G
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
K
E
----------------------------------------------
75
PsiBlast_CBE
85.29
49%
-114
- C1 -
3TI1
8
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-----T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
66
PsiBlast_CBE
85.22
49%
-116
- C1 -
4D1X
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
------------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
97
PsiBlast_CBE
85.17
49%
-108
- C1 -
2X1N
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
-
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
--------------------------------------
52
PsiBlast_CBE
84.97
49%
-110
- C1 -
4FX3
2
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
-
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
26
PsiBlast_CBE
84.80
50%
-105
- C1 -
1V0O
1
CDC2H_PLAFK
B:
[3-285]
------------------------------------------------------------------------------------------------------
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
N
--
Y
-
G
E
T
F
A
L
K
K
I
R
L
-----------
T
I
R
E
I
S
I
L
K
E
L
K
H
S
N
I
V
K
L
Y
D
V
I
H
--
T
------
K
-
K
R
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
V
---
C
-----
E
-
G
G
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
R
-
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
G
I
-
P
V
R
K
Y
T
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
-
G
T
P
L
F
P
G
V
S
E
A
-----
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
E
L
P
K
Y
D
P
N
F
T
V
Y
E
P
L
----
P
W
E
S
F
L
K
--------
G
L
--
D
-
E
---
S
G
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
K
E
N
---------------------------------------------
12
PsiBlast_PDB
84.40
50%
-108
- C1 -
1V0O
1
CDC2H_PLAFK
A:
[3-285]
------------------------------------------------------------------------------------------------------
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
N
--
Y
-
G
E
T
F
A
L
K
K
I
R
L
---------
S
T
T
I
R
E
I
S
I
L
K
E
L
K
H
S
N
I
V
K
L
Y
D
V
I
H
--
T
------
K
-
K
R
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
V
---
C
-----
E
-
G
G
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
R
-
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
G
I
-
P
V
R
K
Y
T
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
-
G
T
P
L
F
P
G
V
S
E
A
-----
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
E
L
P
K
Y
D
P
N
F
T
VYE
P
L
----
P
W
E
S
F
L
K
--------
G
L
--
D
-
E
---
S
G
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
K
E
N
---------------------------------------------
47
PsiBlast_CBE
83.89
49%
-121
- C1 -
5D1J
1
?
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
---------------
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
3
PsiBlast_PDB
83.08
51%
-104
- C1 -
2PMI
2
PHO85_YEAST
A:
[19-298]
-------------------------------------------------------------------------------------------------------------------
A
T
V
Y
K
G
L
N
K
--
T
T
G
V
Y
V
A
L
K
E
V
K
L
D
S
-
E
-
E
G
T
P
S
T
A
I
R
E
I
S
L
M
K
E
L
K
H
E
N
I
V
R
L
Y
D
V
I
H
--
T
------
E
-
N
K
L
T
L
V
F
E
F
M
D
N
D
L
K
K
Y
M
D
S
---
R
TVGN
T
P
-
R
G
L
E
L
N
L
V
K
Y
F
Q
W
Q
L
L
Q
G
L
A
F
C
H
E
N
K
I
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
K
-
R
G
Q
L
K
L
G
D
F
G
L
A
R
A
F
G
I
-
P
V
N
T
F
S
S
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
R
T
Y
S
T
S
I
D
I
W
S
C
G
C
I
L
A
E
M
I
T
-
G
K
P
L
F
P
G
-
T
N
D
----
E
E
Q
L
K
L
I
F
D
I
M
G
T
P
N
E
S
L
W
P
S
V
T
K
L
P
K
Y
N
P
N
I
Q
---
Q
R
----
P
-
P
R
D
L
R
Q
V
L
Q
P
H
--
T
K
--
E
-
P
LD
G
N
L
M
D
F
L
H
G
L
L
Q
L
N
P
D
M
R
L
S
A
K
Q
A
L
H
H
P
W
F
A
E
Y
Y
H
-------------------------------------------
46
PsiBlast_CBE
80.87
49%
-115
- C1 -
4EOQ
1
CDK2_HUMAN
C:
[1-290]
-----------------------------------------------------------------------------------------------
P
L
-
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
-
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
--------------------------------
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
--------------------------------------
118
HHSearch
80.64
38%
-110
- C1 -
4NST
3
CDK12_HUMAN
A:
[13-313]
-----------------------------------------------------------------------------------------------------
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
K
--
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
-
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
H
R
S
V
V
N
M
K
E
I
V
T
--
D
KQD-----
G
A
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
S
---
G
-----
L
-
V
H
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
----
N
-
N
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
S
E
E
S
R
P
Y
T
N
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
-
K
K
P
I
F
Q
A
N
L
-
E
----
L
A
Q
L
E
L
I
S
R
L
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
T
M
K
P
---
K
K
----
Q
Y
R
R
R
L
R
E
E
F
S
-----
F
--
I
-
P
S
--
A
A
L
D
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
T
L
Q
S
D
F
L
K
D
V
E
L
S
K
M
A
P
P
D
L
P
H
W
Q
D
C
H
E
L
W
S
K
K
----------------------
115
HHSearch
78.81
35%
-113
- C1 -
1J1B
1
GSK3B_HUMAN
A:
[54-354]
-----------------------------------------------------------------------------------------------------
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
--
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
K
-
R
------
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
--
S
S
GEKKD
E
-
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
-----
K
-
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
----
D
-
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
--
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-
G
Q
P
I
F
P
G
D
S
-
G
----
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
--
N
P
N
Y
T
E
F
K
F
---
P
Q
----
I
K
A
H
P
W
T
K
V
F
R
P
---
R
T
--
P
-
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
A
A
A
106
HHSearch
77.82
32%
-113
- C1 -
3EB0
3
?
A:
[6-329]
----------------------------------------------------------------------------------------------------
S
K
K
Y
S
L
G
K
T
L
G
T
G
-
F
G
I
V
C
E
V
F
D
I
--
E
S
G
K
R
F
A
L
K
K
V
L
Q
D
P
-
R
------
Y
K
N
R
E
L
D
I
M
K
V
L
D
H
V
N
I
I
K
L
V
D
Y
F
Y
--
T
------
T
N
K
Y
L
N
V
I
M
E
Y
V
P
D
T
L
H
K
V
L
K
S
F
I
R
S
-----
G
-
R
S
I
P
M
N
L
I
S
I
Y
I
Y
Q
L
F
R
A
V
G
F
I
H
S
L
G
I
C
H
R
D
I
K
P
Q
N
L
L
V
----
N
S
K
-
D
N
T
L
K
L
C
D
F
G
S
A
K
K
L
I
--
P
S
E
P
S
V
A
Y
I
C
S
R
F
Y
R
A
P
E
L
M
L
G
A
T
E
Y
T
P
S
I
D
L
W
S
I
G
C
V
F
G
E
L
I
L
-
G
K
P
L
F
S
G
E
T
-
S
----
I
D
Q
L
V
R
I
I
Q
I
M
G
T
P
T
K
E
Q
M
I
R
M
N
--
P
H
Y
--
V
R
F
---
P
T
----
L
K
A
K
D
W
R
K
I
L
P
E
---
G
T
--
P
-
S
---
L
A
I
D
L
L
E
Q
I
L
R
Y
E
P
D
L
R
I
N
P
Y
E
A
M
A
H
P
F
F
D
H
L
R
N
S
I
P
Q
L
F
N
F
S
P
Y
E
L
S
I
I
P
G
N
V
L
N
R
I
L
P
K
----------------
103
HHSearch
73.10
41%
-97
- C1 -
1UA2
1
CDK7_HUMAN
A:
[13-299]
--------------------------------------------------------------------------------------------------------
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
K
--
N
T
N
Q
I
V
A
I
K
K
I
----------
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
S
H
P
N
I
I
G
L
L
D
A
F
G
--
H
------
K
-
S
N
I
S
L
V
F
D
F
M
E
T
D
L
E
V
I
I
K
D
---
N
-----
S
-
L
V
L
T
P
S
H
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
----
D
-
E
-
N
G
V
L
K
L
A
D
F
G
L
A
K
S
F
G
S
-
P
N
R
A
Y
T
H
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
L
-
R
V
P
F
L
P
G
D
S
-
D
----
L
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
E
Q
W
P
D
M
C
S
L
P
D
Y
V
T
--
F
---
K
S
----
F
P
G
I
P
L
H
H
I
F
S
-----
A
--
A
G
D
---
D
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
S
N
R
P
G
P
T
P
G
C
Q
L
P
R
P
N
--------------------------------
117
HHSearch
72.15
34%
-106
- C1 -
4F6U
10
CDK8_HUMAN
A:
[27-341]
-----------------------------------------------------------------------------------------------------------
C
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
DG
K
D
D
K
D
Y
A
L
K
Q
I
E
----
G
-
T
G
I
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
H
A
------
D
-
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
---
H
R
A
S
K---
V
Q
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
M
G
EG
P
-
E
-
R
G
R
V
K
I
A
D
M
G
F
---------------
V
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
-
S
E
P
I
F
H
C
R
Q
E
-NPYH
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
S
T
L
M
K
---
D
F
RRNT
Y
T
N
C
S
L
I
K
Y
M
E
K
H
--
K
V
KP
D
-
S
---
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
------------------------
54
PsiBlast_CBE
52.17
49%
0
- C1 -
4FKV
2
CDK2_HUMAN
A:
[6-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
56
PsiBlast_CBE
51.89
49%
-1
- C1 -
4FKQ
2
CDK2_HUMAN
A:
[6-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
76
PsiBlast_CBE
51.67
49%
-2
- C1 -
3SW7
1
CDK2_HUMAN
A:
[6-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
55
PsiBlast_CBE
51.64
49%
1
- C1 -
4FKR
2
CDK2_HUMAN
A:
[6-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
53
PsiBlast_CBE
51.41
49%
1
- C1 -
4FKW
2
CDK2_HUMAN
A:
[6-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
84
PsiBlast_CBE
51.23
49%
4
- C1 -
3IGG
1
CDK2_HUMAN
A:
[6-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
64
PsiBlast_CBE
51.16
49%
4
- C1 -
4EK5
1
CDK2_HUMAN
A:
[6-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
58
PsiBlast_CBE
51.04
49%
4
- C1 -
4FKO
1
CDK2_HUMAN
A:
[6-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
65
PsiBlast_CBE
50.95
49%
8
- C1 -
4EK4
1
CDK2_HUMAN
A:
[6-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
--------------------------------------
60
PsiBlast_CBE
50.94
49%
1
- C1 -
4FKJ
1
CDK2_HUMAN
A:
[6-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
63
PsiBlast_CBE
50.84
49%
3
- C1 -
4EK6
1
CDK2_HUMAN
A:
[6-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
-----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
-----------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
61
PsiBlast_CBE
50.69
49%
5
- C1 -
4FKG
1
CDK2_HUMAN
A:
[6-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
101
PsiBlast_CBE
50.12
49%
2
- C1 -
2W17
1
CDK2_HUMAN
A:
[6-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
-
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------
85
PsiBlast_CBE
49.69
49%
4
- C1 -
3IG7
1
CDK2_HUMAN
A:
[6-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
--
T
------
E
-
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-----
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
---
P
K
----
W
A
R
Q
D
F
S
K
V
V
P
P
L
--
D
E
--------
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
R
L
------------------------------------