@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : IRAK1_HUMAN: (2015-10-09 )
MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQFAALIVRDQTELRLCERSGQRTASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTAPRPSSIPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTKPGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDPRPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQVYERLEKLQAVVAGVPGHSEAASCIPPSPQENSYVSSTGRAHSGAAPWQPLAAPSGASAQAAEQLQRGPNQPVESDESLGGLSAALRSWHLTPSCPLDPAPLREAGCPQGDTAGESSWGSGPGSRPTAVEGLALGSSASSSSEPPQIIINPARQKMVQKLALYEDGALDSLQLLSSSSLPGLGLEQDRQGPEESDEFQS
Atome Classification :
(18 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210...------....220.......230.-......240.......250.......260.......270.......280.......290.......300.......310.......320.......330-.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490...---....500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAGGPGPGEPAAPGAQ
H
F
L
YEV
P
P
W
V
M
C
R
F
Y
K
V
M
D
AL
E
P
A
D
W
C
Q
F
A
A
L
I
VRD
Q
T
E
L
R
L
C
E
RSGQR
T
A
S
V
L
W
P
W
INRNA
R
V
A
D
L
V
H
I
L
T
H
L
Q
L
L
R
ARD
I
I
TAWHPPAPLPSPGTTAPRPSSIPAPAEAEAWSPRKLPSS
A
S
T
FLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTKPGP
E
S
S
V
S
L
L
QGARPFPF
C
W
P
L
C
E
ISRGTHNF
S
E
E------LKIGEG
G
F
G
C
V
Y
R
A
V
M
R
N
-
T
V
Y
A
V
K
R
L
KENADL
E
W
T
A
V
K
Q
S
F
L
T
E
V
E
Q
L
S
RFRHPN
I
V
D
F
A
G
Y
C
A
QN
G
F
Y
C
L
V
Y
G
FLPNGSL
E
D
R
L
H
CQTQACPPLS
W
P
Q
R
L
D
I
L
L
G
T
A
R
A
I
Q
F
L
HQD-SPS
L
I
H
GDIKSS
N
V
L
LDERLTPKLG
D
F
G
L
A
R
F
S
R
FAGSSPSQ
S
S
M
V
A
R
T
Q
TVR
G
T
L
A
YL
P
E
E
Y
I
KTG
R
L
A
VDTDTF
S
F
G
V
V
V
L
E
T
L
AGQ
R
A
V
K
THG
A
R
T
K
Y
L
K
D
L
V
E
E
E
A
E
EA
G
V
A
L
R
S
T
Q
S
T
L
Q
AGLAADAWA
A
P
I
A
M
Q
I
Y
K
K
HLDPRPGPC
P
P
E
LGL
G
L
G
Q
---
L
A
C
C
C
L
H
R
R
AKRRP
P
M
T
Q
V
Y
E
R
L
E
K
L
Q
A
V
V
AGVPGHS
E
A
ASCIPPSPQENSYVSSTGRAHSGAAPWQPLAAPSGA
S
A
Q
A
A
E
Q
L
QRGPNQPVESDESL
G
G
L
S
A
A
L
R
SWHLTPSCPLDPAPLREAGCPQGDTAGESSWGSGPGSRP
T
A
V
E
G
L
ALGSSASSSSEP
P
Q
I
I
I
N
P
A
R
Q
K
M
V
Q
K
L
A
LYEDGA
L
D
S
L
Q
L
L
SSSSLPGLG
L
E
QDRQGPEESDEFQS
5
PsiBlast_PDB
90.95
34%
-93
- C3 -
2OIC
1
IRAK4_HUMAN
A:
[9-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
PISVGG
N
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
-
T
T
V
A
V
K
K
-----------
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-
L
D
G
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
-
H
H
--
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
R
----
A
------
T
V
M
T
S
R
---
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
-
G
E
I
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
D
E
H
----------------------
R
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
N
D
A
D
S
T
S
V
E
-----
A
M
Y
S
---
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
89.18
34%
-92
- C3 -
2NRY
1
IRAK4_HUMAN
A:
[15-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
PISVGG
N
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
-
T
T
V
A
V
K
K
L
A
A
---
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-
L
D
G
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
-
H
H
--
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
R
A
S
---------
T
V
M
T
S
R
---
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
-
G
E
I
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
D
E
H
----------------------
R
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
N
D
A
D
S
T
S
V
E
-----
A
M
Y
S
---
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
89.01
34%
-90
- C3 -
2NRU
1
IRAK4_HUMAN
A:
[15-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
PISVGG
N
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
-
T
T
V
A
V
K
K
L
A
A
M
V
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-
L
D
G
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
-
H
H
--
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
R
----
A
S
E
K
F
A
Q
T
V
M
T
S
R
---
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
-
G
E
I
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
D
E
H
----------------------
R
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
N
D
A
D
S
T
S
V
E
-----
A
M
Y
S
---
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
88.83
33%
-82
- C3 -
4OH4
1
BRI1_ARATH
A:
[34-321]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
D
L
L
Q
A
T
N
G
F
H
N
D
------
S
L
I
G
S
G
G
F
G
D
V
Y
K
A
I
L
K
D
G
S
A
V
A
I
K
K
L
I
H
V
S
----
G
Q
G
D
R
E
F
M
A
E
M
E
T
I
G
K
I
K
H
R
N
L
V
P
L
L
G
Y
C
K
V
G
D
E
R
L
L
V
Y
E
F
M
K
Y
G
S
L
E
D
V
L
H
D
------
K
L
N
W
S
T
R
R
K
I
A
I
G
S
A
R
G
L
A
F
L
H
H
N
C
S
P
H
I
I
H
R
D
M
K
S
S
N
V
L
L
D
E
N
L
E
A
R
V
S
D
F
G
M
A
R
L
M
-------
S
A
M
D
T
H
L
S
V
S
T
L
A
G
T
P
G
Y
V
P
P
E
Y
Y
Q
S
F
R
C
S
T
K
G
D
V
Y
S
Y
G
V
V
L
L
E
L
L
T
G
K
R
P
T
D
S
P
D
F
G
D
N
N
L
V
G
W
V
K
Q
H
A
K
-----
L
R
I
S
D
V
-----------------------
F
D
P
E
L
M
K
E
D
P
A
L
E
I
E
L
L
Q
H
L
K
V
A
V
A
C
L
D
D
R
A
W
R
R
P
T
M
V
Q
V
M
A
M
F
K
E
I
Q
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
86.28
33%
-86
- C3 -
2NRU
1
IRAK4_HUMAN
C:
[15-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
PISVGG
N
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
-
T
T
V
A
V
K
K
L
A
A
M
V
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-
L
D
G
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
-
H
H
--
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
R
----
A
S
E
K
F
A
Q
T
V
M
T
S
---
R
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
-
G
E
I
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
D
E
H
----------------------
R
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
N
D
A
D
S
T
S
V
E
-----
A
M
Y
S
---
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
86.26
32%
-81
- C3 -
4Q5J
1
BRI1_ARATH
A:
[34-321]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
D
L
L
Q
A
T
N
G
F
H
N
D
------
S
L
I
G
S
G
G
F
G
D
V
Y
K
A
I
L
K
D
G
S
A
V
A
I
K
K
L
I
H
V
S
-------
D
R
E
F
M
A
E
M
E
T
I
G
K
I
K
H
R
N
L
V
P
L
L
G
Y
C
K
V
G
D
E
R
L
L
V
Y
E
F
M
K
Y
G
S
L
E
D
V
L
--------
K
L
N
W
S
T
R
R
K
I
A
I
G
S
A
R
G
L
A
F
L
H
H
N
C
S
P
H
I
I
H
R
D
M
K
S
S
N
V
L
L
D
E
N
L
E
A
R
V
S
D
F
G
M
A
R
L
M
-------
S
A
M
D
T
H
L
S
V
S
T
L
A
G
T
P
G
Y
V
P
P
E
Y
Y
Q
S
F
R
C
S
T
K
G
D
V
Y
S
Y
G
V
V
L
L
E
L
L
T
G
K
R
P
T
D
S
P
D
F
G
D
N
N
L
V
G
W
V
K
Q
H
A
K
-----
L
R
I
S
D
V
-----------------------
F
D
P
E
L
M
K
E
D
P
A
L
E
I
E
L
L
Q
H
L
K
V
A
V
A
C
L
D
D
R
A
W
R
R
P
T
M
V
Q
V
M
A
M
F
K
E
I
Q
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
86.21
34%
-96
- C3 -
4U97
1
IRAK4_HUMAN
B:
[20-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
PISVGG
N
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
-
T
T
V
A
V
K
K
L
A
A
--------
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
---
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-
L
D
G
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
-
H
H
--
I
H
R
N
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
----------------
V
M
T
S
R
---
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
-
G
E
I
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
D
E
H
----------------------
R
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
N
D
A
D
S
T
S
V
E
-----
A
M
Y
S
---
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
86.12
34%
-95
- C3 -
4U97
1
IRAK4_HUMAN
A:
[20-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
PISVGG
N
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
-
T
T
V
A
V
K
K
L
A
A
--------
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-
L
D
G
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
-
H
H
--
I
H
R
N
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
------------
T
V
M
T
S
R
---
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
-
G
E
I
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
D
E
H
----------------------
R
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
N
D
A
D
S
T
S
V
E
-----
A
M
Y
S
---
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
85.33
34%
-98
- C3 -
4U9A
1
IRAK4_HUMAN
B:
[20-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
PISV
G
G
N
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
-
T
T
V
A
V
K
K
L
A
A
--------
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
---
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-
L
D
G
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
-
H
H
--
I
H
R
N
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
----------------
V
M
T
S
R
---
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
-
G
E
I
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
D
E
H
----------------------
R
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
N
D
A
D
S
T
S
V
E
-----
A
M
Y
S
---
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
85.25
33%
-85
- C3 -
2NRU
1
IRAK4_HUMAN
B:
[15-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
PISVGG
N
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
-
T
T
V
A
V
K
K
L
A
A
M
V
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-
L
D
G
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
-
H
H
--
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
R
----
A
S
E
K
F
A
Q
T
V
M
T
S
---
R
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
-
G
E
I
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
D
E
H
----------------------
R
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
N
D
A
D
S
T
S
V
E
-----
A
M
Y
S
---
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
85.01
33%
-78
- C3 -
4OAB
1
A:
[12-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
D
L
L
Q
A
T
N
G
F
H
N
D
------
S
L
I
G
S
G
G
F
G
D
V
Y
K
A
I
L
K
D
G
S
A
V
A
I
K
K
L
I
H
V
S
----
G
Q
G
D
R
E
F
M
A
E
M
E
T
I
G
K
I
K
H
R
N
L
V
P
L
L
G
Y
C
K
V
G
D
E
R
L
L
V
Y
E
F
M
K
Y
G
S
L
E
D
V
L
H
D
P
K
K
A
G
V
K
L
N
W
S
T
R
R
K
I
A
I
G
S
A
R
G
L
A
F
L
H
H
N
C
S
P
H
I
I
H
R
D
M
K
S
S
N
V
L
L
D
E
N
L
E
A
R
V
S
D
F
G
M
A
R
L
M
-------
S
A
M
D
T
H
L
S
V
S
T
L
A
G
T
P
G
Y
V
P
P
E
Y
Y
Q
S
F
R
C
S
T
K
G
D
V
Y
S
Y
G
V
V
L
L
E
L
L
T
G
K
R
P
T
D
S
------------
K
Q
H
A
K
-----
L
R
I
S
D
V
-----------------------
F
D
P
E
L
M
K
E
D
P
A
L
E
I
E
L
L
Q
H
L
K
V
A
V
A
C
L
D
D
R
A
W
R
R
P
T
M
V
Q
V
M
A
M
F
K
E
I
Q
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
84.81
33%
-84
- C3 -
2NRU
1
IRAK4_HUMAN
D:
[15-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
PISVGG
N
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
-
T
T
V
A
V
K
K
L
A
A
M
V
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-
L
D
G
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
-
H
H
--
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
R
----
A
S
E
K
F
A
Q
T
V
M
T
S
---
R
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
-
G
E
I
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
D
E
H
----------------------
R
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
N
D
A
D
S
T
S
V
E
-----
A
M
Y
S
---
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
84.50
33%
-76
- C3 -
4OAC
2
A:
[12-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
D
L
L
Q
A
T
N
G
F
H
N
D
------
S
L
I
G
S
G
G
F
G
D
V
Y
K
A
I
L
K
D
G
S
A
V
A
I
K
K
L
I
H
V
S
----
G
Q
G
D
R
E
F
M
A
E
M
E
T
I
G
K
I
K
H
R
N
L
V
P
L
L
G
Y
C
K
V
G
D
E
R
L
L
V
Y
E
F
M
K
Y
G
S
L
E
D
V
L
H
D
P
K
K
A
G
V
K
L
N
W
S
T
R
R
K
I
A
I
G
S
A
R
G
L
A
F
L
H
H
N
C
S
P
H
I
I
H
R
D
M
K
S
S
N
V
L
L
D
E
N
L
E
A
R
V
S
D
F
G
M
A
R
L
M
-------
S
A
M
D
T
H
L
S
V
S
T
L
A
G
T
P
G
Y
V
P
P
E
Y
Y
Q
S
F
R
C
S
T
K
G
D
V
Y
S
Y
G
V
V
L
L
E
L
L
T
G
K
R
P
T
D
S
------------
K
Q
H
A
K
-----
L
R
I
S
D
V
-----------------------
F
D
P
E
L
M
K
E
D
P
A
L
E
I
E
L
L
Q
H
L
K
V
A
V
A
C
L
D
D
R
A
W
R
R
P
T
M
V
Q
V
M
A
M
F
K
E
I
Q
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
84.48
33%
-77
- C3 -
4OA9
1
A:
[12-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
D
L
L
Q
A
T
N
G
F
H
N
D
------
S
L
I
G
S
G
G
F
G
D
V
Y
K
A
I
L
K
D
G
S
A
V
A
I
K
K
L
I
H
V
S
----
G
Q
G
D
R
E
F
M
A
E
M
E
T
I
G
K
I
K
H
R
N
L
V
P
L
L
G
Y
C
K
V
G
D
E
R
L
L
V
Y
E
F
M
K
Y
G
S
L
E
D
V
L
H
D
P
K
K
A
G
V
K
L
N
W
S
T
R
R
K
I
A
I
G
S
A
R
G
L
A
F
L
H
H
N
C
S
P
H
I
I
H
R
D
M
K
S
S
N
V
L
L
D
E
N
L
E
A
R
V
S
D
F
G
M
A
R
L
M
-------
S
A
M
D
T
H
L
S
V
S
T
L
A
G
T
P
G
Y
V
P
P
E
Y
Y
Q
S
F
R
C
S
T
K
G
D
V
Y
S
Y
G
V
V
L
L
E
L
L
T
G
K
R
P
T
D
S
------------
K
Q
H
A
K
-----
L
R
I
S
D
V
-----------------------
F
D
P
E
L
M
K
E
D
P
A
L
E
I
E
L
L
Q
H
L
K
V
A
V
A
C
L
D
D
R
A
W
R
R
P
T
M
V
Q
V
M
A
M
F
K
E
I
Q
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
83.90
34%
-94
- C3 -
4U9A
1
IRAK4_HUMAN
A:
[20-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
PISVGG
N
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
-
T
T
V
A
V
K
K
L
A
A
--------
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-
L
D
G
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
-
H
H
--
I
H
R
N
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
------------
T
V
M
T
S
R
---
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
-
G
E
I
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
D
E
H
----------------------
R
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
N
D
A
D
S
T
S
V
E
-----
A
M
Y
S
---
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
81.80
33%
-70
- C3 -
4OA2
1
A:
[12-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
D
L
L
Q
A
T
N
G
F
H
N
D
------
S
L
I
G
S
G
G
F
G
D
V
Y
K
A
I
L
K
D
G
S
A
V
A
I
K
K
L
I
H
V
S
----
G
Q
G
D
R
E
F
M
A
E
M
E
T
I
G
K
I
K
H
R
N
L
V
P
L
L
G
Y
C
K
V
G
D
E
R
L
L
V
Y
E
F
M
K
Y
G
S
L
E
D
V
L
H
D
P
K
K
A
G
V
K
L
N
W
S
T
R
R
K
I
A
I
G
S
A
R
G
L
A
F
L
H
H
N
C
S
P
H
I
I
H
R
D
M
K
S
S
N
V
L
L
D
E
N
L
E
A
R
V
S
D
F
G
M
A
R
L
M
-------
S
A
M
D
T
H
L
S
V
S
T
L
A
G
T
P
G
Y
V
P
P
E
Y
Y
Q
S
F
R
C
S
T
K
G
D
V
Y
S
Y
G
V
V
L
L
E
L
L
T
G
K
R
P
T
D
S
------------
K
Q
H
A
K
-----
L
R
I
S
D
V
-----------------------
F
D
P
E
L
M
K
E
D
P
A
L
E
I
E
L
L
Q
H
L
K
V
A
V
A
C
L
D
D
R
A
W
R
R
P
T
M
V
Q
V
M
A
M
F
K
E
I
Q
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
72.74
34%
-62
- C3 -
4ZTM
1
?
A:
[9-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
PISVGG
N
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
-
T
T
V
A
V
K
K
L
A
-----
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-
L
D
G
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
-
H
H
--
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
R
----
A
S
E
---
Q
T
V
M
T
S
R
---
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
-
G
E
I
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
D
E
H
----------------------
R
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
N
D
A
D
S
T
S
V
E
-----
A
M
Y
S
---
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
71.95
34%
-63
- C3 -
4YO6
1
IRAK4_HUMAN
A:
[9-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
PISVGG
N
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
-
T
T
V
A
V
K
K
L
A
-----
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-
L
D
G
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
-
H
H
--
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
R
----
A
S
E
---
Q
T
V
M
T
S
R
---
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
-
G
E
I
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
D
E
H
----------------------
R
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
N
D
A
D
S
T
S
V
E
-----
A
M
Y
S
---
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------