@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0263: (2015-11-29 )
MDDFIRIKGAREHNLQGVDVNIPKNKLVVITGLSGSGKSSLAFDTIYAEGQRRYVESLSAYARQFLNIQDKPDVESITGLSPAISINQKSISKNPRSTVGTVTEIYDYLRLMYARIGIPYSPATGLPIAKQTVSQIVDTIMALPLETKIYILAPIVRGRKGEHLKEILEIKKQGYVRLKIDGEVHNIDDLPKLDENKKHNIFVVADRILVSDNIGNRLPSSIESALRLGHGLMYAEIMSLPDNHNSEYKDGQILTFSENFACPESGFTLEELEPRLFSFNSPYGACYLCNGLGKKLDIDIKLIVPDETLSISEGALRPVGSMSRQVHASYGFLKSAILSLAENRKFSLDIPWKNIDQKVKNVILFGSKETKFRGLVGILENQIDYDETLIERYCSVANCKECVGFRIRKEALTVKIDGRHIGEISRLSIDEFLKWFENLPSKLTEQQKQISNKILNEIIKRLTFLKNVGLNYLTLDRESSTLSGGESQRIRLASQIGSGLTGVLYVLDEPSIGLHQCDNDRLIATLKNLRDMGNTVIVVEHDEDTIMAADYAIDIGPGAGVNGGKIVAEGTPDQVQRSSKSITGQYLSGKKTISIPKRRKRATQYIKVVNACENNLKNIDVEFPIGNLICVTGISGGGKSSLVVETLYKYLARKMYDSSAKYGQCDKIEGLEYIDKIIEIDQSPIGRTPASNPATYVGIFTHVRNWFAGLPESKARGYNIGRFSFNTKGGRCEACKGDGHLRVEMHFLPDVYVKCEQCKGRRYNRETLEVTYKGKSVSDVLDMTIDQACDFFDNLPMVKEKLVSLQEVGLGYIKLGQPSTTLSGGEAQRIKLSRELSKRSTGRTLYILDEPTTGLHFEDVNNLLKILHKLVDLGNTVIVIEHNLHVIKTADYIIDIGPEGGMKGGKVVATGTPEEIIDIPESITGKYLKPYLSKLIKV
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230......--.240.......250.......260...-....270.......280.......290.......300.......310.......-----320.......330.......340.......350.......360...-------------------------------..------------------..-----------------370.----------------..-----------------------......380--------.-----.-----...-..--.390......---.400.......410......--------.420......---.430....--...440----.....------.----..450.......460.......470.......480.......490.......500........510.......520.......530.......540.....-.-.550.......560.......570.......580.......590-------.----------.--..-----.-.-.---.600--.-......610---.----.----......620.......630.......640.......650.......660-------..------------------.....670....-....680.......690.......700.......710...--....720.......730.......740..------------------------------------------.-------------------------------------------....----------------------------750.......760.......770.......780.......790..--.--------------------------....800.......810.......820.......830.......840.......850.......860.......870-.......880......-.890.......900.......910.......920.......930......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MD
D
F
I
R
I
KGAREHNLQ
G
V
D
VNIPKN
K
L
V
V
I
TGLSGSGKS
S
L
A
F
D
T
I
Y
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
LNIQDKPD
V
E
S
ITGLSP
A
I
S
IN
Q
K
SISKNPRSTVG
T
V
T
E
I
Y
D
Y
L
R
L
M
Y
A
R
IGIPYSPATGLP
I
A
K
Q
T
V
S
Q
I
V
D
T
I
M
ALPLE
T
K
I
Y
I
L
A
P
I
VRGR
K
G
E
H
L
K
E
I
L
E
I
K
KQ
G
Y
V
R
L
K
IDGEVHNIDDLPKLDENKKH
N
I
F
V
V
A
D
R
I
L
V
SDNIGNRL
P
S
S
I
E
S
A
L
R
LGH
G
L
M
Y
A
E
I
M
--SLPDNHNSEYKD
G
Q
I
L
T
FSENFACPES-GF
T
L
E
E
LE
P
R
L
FSFNSPYG
A
C
Y
L
CNGLGK
K
L
D
I
D
I
K
L
I
VPDETLSISEGALRP
V
-----
G
S
M
S
R
Q
V
H
A
S
Y
G
F
L
K
S
A
I
L
S
L
AEN
R
K
F
S
L
DIP
W
K
N
I
D
Q
K
V
K
N
V
I
L
F-------------------------------GS------------------KE-----------------
T
--
K
----------------
F
R
-----------------------
G
L
V
G
I
L
EN---------Q-----I-----D
Y
D
-
E
T
--
L
I
E
R
Y
C
S
V
A
N
---
C
K
E
C
V
G
F
R
I
R
K
E
A
L
T
V
K
IDG--------RHIG
E
I
S
RL
S
---
I
D
E
F
L
K
W
F
--
E
N
L
P
S
-----
K
L
T
E
Q
------
Q
----
K
Q
I
S
N
K
I
L
N
E
I
I
K
R
L
T
F
L
K
NVGL
N
Y
L
T
LDRESSTLSGGE
S
Q
R
I
R
L
A
S
Q
IGSGL
T
-
G
V
L
Y
V
LDEPSIGLHQCDN
D
R
L
I
A
T
L
K
N
L
R
DMG
N
T
V
I
V
V
EHDED
T
I
M
-
A
-
A
D
Y
A
I
DIGPGAGVNG
G
K
I
V
AEGT
P
D
Q
V
Q
R
SSKSITGQYLSGKK--------T----------I--S
I
-----
P
-
K
-
R
---
R
K
R
A
--
T
-
Q
Y
I
K
V
V
N
A
----
C
----E----NNLK
N
I
D
V
EFPIG
N
L
I
C
V
TGISGGG
K
S
S
L
V
V
E
T
L
Y
K
Y
L
A
R
K
MYDSSAKY-------GQ------------------CDKIE
G
-
L
E
Y
I
D
-
K
I
I
EIDQSPIGRTPASNP
A
T
Y
V
G
I
F
T
H
V
R
N
W
F
AGLPESKA--RG
Y
N
I
G
R
F
S
FNTKGGRC
E
A
CKGD
G
H
L
R
V
E
------------------------------------------
M
-------------------------------------------
H
FLP----------------------------D
V
Y
V
K
C
E
Q
CKGRRYNR
E
T
L
E
V
T
YKGK
S
V
S
D
V
L
D
M
T
I
D
Q
A
C
D
F
F
DN--L--------------------------
P
M
V
K
E
K
L
V
S
L
Q
E
VG
L
G
Y
I
KLGQPSTTLSGGE
A
Q
R
I
K
L
S
R
E
L
S
KRSTG
R
T
L
Y
I
LDEPTTGL
H
F
E
D
V
N
N
L
L
K
I
L
H
K
L
V
D-LG
N
T
V
I
V
I
EHN
L
H
V
I
K
-TA
D
Y
I
I
D
IGPEGGMKG
G
K
V
V
ATG
T
P
E
E
I
I
DI
P
E
S
I
T
G
K
Y
L
K
P
Y
L
S
K
L
IKV
1
PsiBlast_PDB
94.24
57%
-95
- C2 -
3UWX
3
?
A:
[22-958]
--
D
K
I
I
V
K
G
A
R
A
H
N
L
K
N
I
D
V
E
I
P
R
G
K
L
V
V
L
T
G
L
S
G
S
G
K
S
S
L
A
F
D
T
I
Y
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
G
Q
M
E
K
P
D
V
D
A
I
E
G
L
S
P
A
I
S
I
D
Q
K
T
T
S
R
N
P
R
S
T
V
G
T
V
T
E
I
Y
D
Y
L
R
L
L
F
A
R
I
G
R
P
I
C
P
T
H
G
I
E
I
Q
S
Q
T
I
E
Q
M
V
D
R
L
L
S
Y
P
E
R
T
K
M
Q
I
L
A
P
I
V
S
G
K
K
G
T
H
A
K
T
L
E
D
I
R
K
Q
G
Y
V
R
V
R
I
D
R
E
M
R
E
L
T
G
D
I
E
L
E
K
N
K
K
H
S
I
D
V
V
V
D
R
I
I
I
K
D
G
I
A
A
R
L
A
D
S
L
E
T
A
L
K
L
A
D
G
K
V
V
V
D
V
I
--
G
----------
E
G
E
L
L
-
F
S
E
K
H
A
C
P
Y
C
-
G
F
S
I
G
E
L
E
P
R
L
F
S
F
N
S
P
F
G
A
C
P
D
C
D
G
L
G
A
K
L
E
V
D
L
D
L
V
I
P
N
D
E
L
T
L
K
E
H
A
I
A
P
W
-----
E
P
----------
Y
Y
P
Q
L
L
E
A
V
C
R
H
Y
G
I
P
M
D
V
P
V
K
D
L
P
K
E
Q
L
D
K
I
L
Y
-------------------------------
G
S
GG
E
P
I
Y
F
R
Y
T
N
DF
G
Q
V
R
E
Q
Y
-----------------
I
--
A
----------------
F
E
-----------------------
G
V
I
P
N
V
E
R
---------
R
-----
Y
R
E
TSS
D
Y
I
-
R
E
--
Q
M
E
K
Y
M
A
E
Q
P
---
C
P
T
C
Q
G
Y
R
L
K
K
E
S
L
A
V
L
V
G
G
--------
K
H
I
G
E
V
T
A
M
S
---
V
T
E
A
L
A
F
F
--
D
G
L
-------
E
L
T
E
K
------
E
----
A
Q
I
A
R
L
I
L
R
E
I
R
D
R
L
G
F
L
Q
N
V
G
L
D
Y
L
T
L
S
R
S
A
G
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
R
L
T
-
G
V
L
Y
V
L
D
E
P
S
I
G
L
H
Q
R
D
N
D
R
L
I
A
T
L
K
S
M
R
D
L
G
N
T
L
I
V
V
E
H
D
E
D
T
M
L
-
A
-
A
D
Y
L
I
D
I
G
P
G
A
G
I
H
G
G
E
V
V
A
A
G
T
P
E
E
V
M
N
D
P
N
S
L
T
G
Q
Y
L
S
G
K
K
--------
F
----------
I
--
P
I
-----
P
-
A
-
E
---
R
R
R
P
--
D
G
R
W
L
E
V
V
G
A
----
R
----
E
----
H
N
L
K
N
V
S
V
K
I
P
L
G
T
F
V
A
V
T
G
V
S
G
S
G
K
S
T
L
V
N
E
V
L
Y
K
A
L
A
Q
K
L
H
R
A
K
A
K
P
-------
G
E
------------------
H
R
D
I
R
G
-
L
E
H
L
D
-
K
V
I
D
I
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
D
I
R
D
V
F
A
S
T
N
E
A
K
V
--
R
G
Y
K
K
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
H
G
D
G
I
I
K
I
E
------------------------------------------
M
-------------------------------------------
H
F
L
P
----------------------------
D
V
Y
V
P
C
E
V
C
H
G
K
R
Y
N
R
E
T
L
E
V
T
Y
K
G
K
N
I
A
E
V
L
D
M
T
V
E
D
A
L
D
F
F
A
S
--
I
--------------------------
P
K
I
K
R
K
L
E
T
L
Y
D
V
G
L
G
Y
M
K
L
G
Q
P
A
T
T
L
S
G
G
E
A
Q
R
V
K
L
A
A
E
L
H
R
R
S
N
G
R
T
L
Y
I
L
D
E
P
T
T
G
L
H
V
D
D
I
A
R
L
L
D
V
L
H
R
L
V
D
-
N
G
D
T
V
L
V
I
E
H
N
L
D
V
I
K
-
T
A
D
Y
I
I
D
L
G
P
E
G
G
D
R
G
G
Q
I
V
A
V
G
T
P
E
E
V
A
E
V
K
E
S
H
T
G
R
Y
L
K
P
I
L
E
R
D
R
A
R
119
HHSearch
91.90
59%
-94
- C2 -
2R6F
5
?
A:
[21-961]
-
M
D
K
I
I
V
K
G
A
R
A
H
N
L
K
N
I
D
V
E
I
P
R
G
K
L
V
V
L
T
G
L
S
G
S
G
K
S
S
L
A
F
D
T
I
Y
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
G
Q
M
E
K
P
D
V
D
A
I
E
G
L
S
P
A
I
S
I
D
Q
K
T
T
S
R
N
P
R
S
T
V
G
T
V
T
E
I
Y
D
Y
L
R
L
L
F
A
R
I
G
R
P
I
C
P
T
H
G
I
E
I
Q
S
Q
T
I
E
Q
M
V
D
R
L
L
S
Y
P
E
R
T
K
M
Q
I
L
A
P
----------------------------------------------
I
D
V
V
V
D
R
I
I
I
K
D
G
I
A
A
R
L
A
D
S
L
E
T
A
L
K
L
A
D
G
K
V
V
V
D
V
I
--
G
-----------
E
G
E
L
L
F
S
E
K
H
A
C
P
Y
C
-
G
F
S
I
G
E
L
E
P
R
L
F
S
F
N
S
P
F
G
A
C
P
D
C
D
G
L
G
A
K
L
E
V
D
L
D
L
V
I
P
N
D
E
L
T
L
K
E
H
A
I
A
P
W
-----
E
P
--------
Y
Y
P
Q
--
L
L
E
A
V
C
R
H
Y
G
I
P
M
D
V
P
V
K
D
L
P
K
E
Q
L
D
K
I
L
Y
-------------------------------
G
S
------------------
G
G
-----------------
E
P
I
Y
F
R
Y
T
N
DF
G
Q
V
R
E
Q
Y
I
A
F
E
-----------------------
G
V
I
P
N
V
E
R
---------
R
Y
R
E
TS
S
-----
D
Y
I
-
R
E
--
Q
M
E
K
Y
M
A
E
Q
P
---
C
P
T
C
Q
G
Y
R
L
K
K
E
S
L
A
V
L
V
G
G
--------
K
H
I
G
E
V
T
A
M
S
---
V
T
E
A
L
A
F
F
--
D
G
L
E
L
-----
T
E
--
K
------
E
----
A
Q
I
A
R
L
I
L
R
E
I
R
D
R
L
G
F
L
Q
N
V
G
L
D
Y
L
T
L
S
R
S
A
G
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
R
L
T
-
G
V
L
Y
V
L
D
E
P
S
I
G
L
H
Q
R
D
N
D
R
L
I
A
T
L
K
S
M
R
D
L
G
N
T
L
I
V
V
E
H
D
E
D
T
M
L
-
A
-
A
D
Y
L
I
D
I
G
P
G
A
G
I
H
G
G
E
V
V
A
A
G
T
P
E
E
V
M
N
D
P
N
S
L
T
G
Q
Y
L
S
G
K
K
--------
F
----------
I
--
P
I
-----
P
-
A
E
R
---
R
R
P
D
--
G
-
R
W
L
E
V
V
G
A
----
R
----
E
----
H
N
L
K
N
V
S
V
K
I
P
L
G
T
F
V
A
V
T
G
V
S
G
S
G
K
S
T
L
V
N
E
V
L
Y
K
A
L
A
Q
K
L
H
R
A
K
A
K
P
-------
G
E
------------------
H
R
D
I
R
G
-
L
E
H
L
D
-
K
V
I
D
I
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
D
I
R
D
V
F
A
S
T
N
E
A
K
V
--
R
G
Y
K
K
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
H
G
D
G
I
I
K
I
E
------------------------------------------
M
-------------------------------------------
H
F
L
P
----------------------------
D
V
Y
V
P
C
E
V
C
H
G
K
R
Y
N
R
E
T
L
E
V
T
Y
K
G
K
N
I
A
E
V
L
D
M
T
V
E
D
A
L
D
F
F
A
S
--
I
--------------------------
P
K
I
K
R
K
L
E
T
L
Y
D
V
G
L
G
Y
M
K
L
G
Q
P
A
T
T
L
S
G
G
E
A
Q
R
V
K
L
A
A
E
L
H
R
R
S
N
G
R
T
L
Y
I
L
D
E
P
T
T
G
L
H
V
D
D
I
A
R
L
L
D
V
L
H
R
L
V
D
-
N
G
D
T
V
L
V
I
E
H
N
L
D
V
I
K
-
T
A
D
Y
I
I
D
L
G
P
E
G
G
D
R
G
G
Q
I
V
A
V
G
T
P
E
E
V
A
E
V
K
E
S
H
T
G
R
Y
L
K
P
I
L
E
R
D
R
A
R
2
PsiBlast_PDB
91.82
56%
-95
- C2 -
2R6F
5
?
A:
[22-958]
--
D
K
I
I
V
K
G
A
R
A
H
N
L
K
N
I
D
V
E
I
P
R
G
K
L
V
V
L
T
G
L
S
G
S
G
K
S
S
L
A
F
D
T
I
Y
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
G
Q
M
E
K
P
D
V
D
A
I
E
G
L
S
P
A
I
S
I
D
Q
K
T
T
S
R
N
P
R
S
T
V
G
T
V
T
E
I
Y
D
Y
L
R
L
L
F
A
R
I
G
R
P
I
C
P
T
H
G
I
E
I
Q
S
Q
T
I
E
Q
M
V
D
R
L
L
S
Y
P
E
R
T
K
M
Q
I
L
A
P
----------------------------------------------
I
D
V
V
V
D
R
I
I
I
K
D
G
I
A
A
R
L
A
D
S
L
E
T
A
L
K
L
A
D
G
K
V
V
V
D
V
I
--
G
----------
E
G
E
L
L
-
F
S
E
K
H
A
C
P
Y
C
-
G
F
S
I
G
E
L
E
P
R
L
F
S
F
N
S
P
F
G
A
C
P
D
C
D
G
L
G
A
K
L
E
V
D
L
D
L
V
I
P
N
D
E
L
T
L
K
E
H
A
I
A
P
W
-----
E
P
----------
Y
Y
P
Q
L
L
E
A
V
C
R
H
Y
G
I
P
M
D
V
P
V
K
D
L
P
K
E
Q
L
D
K
I
L
Y
-------------------------------
G
S
GG
E
P
I
Y
F
R
Y
T
N
DF
G
Q
V
R
E
Q
Y
-----------------
I
--
A
----------------
F
E
-----------------------
G
V
I
P
N
V
E
R
---------
R
-----
Y
R
E
TSS
D
Y
I
-
R
E
--
Q
M
E
K
Y
M
A
E
Q
P
---
C
P
T
C
Q
G
Y
R
L
K
K
E
S
L
A
V
L
V
G
G
--------
K
H
I
G
E
V
T
A
M
S
---
V
T
E
A
L
A
F
F
--
D
G
L
-------
E
L
T
E
K
------
E
----
A
Q
I
A
R
L
I
L
R
E
I
R
D
R
L
G
F
L
Q
N
V
G
L
D
Y
L
T
L
S
R
S
A
G
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
R
L
T
-
G
V
L
Y
V
L
D
E
P
S
I
G
L
H
Q
R
D
N
D
R
L
I
A
T
L
K
S
M
R
D
L
G
N
T
L
I
V
V
E
H
D
E
D
T
M
L
-
A
-
A
D
Y
L
I
D
I
G
P
G
A
G
I
H
G
G
E
V
V
A
A
G
T
P
E
E
V
M
N
D
P
N
S
L
T
G
Q
Y
L
S
G
K
K
--------
F
----------
I
--
P
I
-----
P
-
A
-
E
---
R
R
R
P
--
D
G
R
W
L
E
V
V
G
A
----
R
----
E
----
H
N
L
K
N
V
S
V
K
I
P
L
G
T
F
V
A
V
T
G
V
S
G
S
G
K
S
T
L
V
N
E
V
L
Y
K
A
L
A
Q
K
L
H
R
A
K
A
K
P
-------
G
E
------------------
H
R
D
I
R
G
-
L
E
H
L
D
-
K
V
I
D
I
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
D
I
R
D
V
F
A
S
T
N
E
A
K
V
--
R
G
Y
K
K
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
H
G
D
G
I
I
K
I
E
------------------------------------------
M
-------------------------------------------
H
F
L
P
----------------------------
D
V
Y
V
P
C
E
V
C
H
G
K
R
Y
N
R
E
T
L
E
V
T
Y
K
G
K
N
I
A
E
V
L
D
M
T
V
E
D
A
L
D
F
F
A
S
--
I
--------------------------
P
K
I
K
R
K
L
E
T
L
Y
D
V
G
L
G
Y
M
K
L
G
Q
P
A
T
T
L
S
G
G
E
A
Q
R
V
K
L
A
A
E
L
H
R
R
S
N
G
R
T
L
Y
I
L
D
E
P
T
T
G
L
H
V
D
D
I
A
R
L
L
D
V
L
H
R
L
V
D
-
N
G
D
T
V
L
V
I
E
H
N
L
D
V
I
K
-
T
A
D
Y
I
I
D
L
G
P
E
G
G
D
R
G
G
Q
I
V
A
V
G
T
P
E
E
V
A
E
V
K
E
S
H
T
G
R
Y
L
K
P
I
L
E
R
D
R
A
R
3
PsiBlast_PDB
88.46
52%
-84
- C2 -
3ZQJ
3
UVRA_MYCTU
A:
[23-970]
-
A
D
R
L
I
V
K
G
A
R
E
H
N
L
R
S
V
D
L
D
L
P
R
D
A
L
I
V
F
T
G
L
S
G
S
G
K
S
S
L
A
F
D
T
I
F
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
G
Q
M
D
K
P
D
V
D
F
I
E
G
L
S
P
A
V
S
I
D
Q
K
S
T
N
R
N
P
R
S
T
V
G
T
I
T
E
V
Y
D
Y
L
R
L
L
Y
A
R
A
G
T
P
H
C
P
T
C
G
E
R
V
A
R
Q
T
P
Q
Q
I
V
D
Q
V
L
A
M
P
E
G
T
R
F
L
V
L
A
P
V
V
R
T
R
K
G
E
F
A
D
L
F
D
K
L
N
A
Q
G
Y
S
R
V
R
V
D
G
V
V
H
P
L
T
D
P
P
K
L
K
K
Q
E
K
H
D
I
E
V
V
V
D
R
L
T
V
K
A
A
A
K
R
R
L
T
D
S
V
E
T
A
L
N
L
A
D
G
I
V
V
L
E
F
V
D--------
E
Q
-------
R
F
S
E
K
L
A
C
P
N
G
H
A
L
A
V
D
D
L
E
P
R
S
F
S
F
N
S
P
Y
G
A
C
P
E
C
S
G
L
G
I
R
K
E
V
D
P
E
L
V
V
P
D
P
D
R
T
L
A
Q
G
A
V
A
P
W
-----
S
N
G
----
H
T
A
E
Y
F
T
R
-
M
M
A
G
L
G
E
A
L
G
F
D
V
D
T
P
W
R
K
L
P
A
K
A
R
K
A
I
L
E
-------------------------------
G
A
------------------
D
E
Q
V
H
V
R
Y
R
N
RYGRTR
S
Y
Y
A
--
D
----------------
F
E
-----------------------
G
V
L
A
F
L
Q
R
---------
K
-----
M
-----
S
Q
T
-
E
S
E
Q
M
K
E
R
Y
E
G
F
M
R
D
V
P
C
P
V
C
A
G
T
R
L
K
P
E
I
L
A
V
T
L
A
G
E
SKGEH
G
A
K
S
I
A
E
V
C
E
L
S
---
I
A
D
C
A
D
F
L
--
N
A
L
-------
T
L
G
P
R
------
E
----
Q
A
I
A
G
Q
V
L
K
E
I
R
S
R
L
G
F
L
L
D
V
G
L
E
Y
L
S
L
S
R
A
A
A
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
G
L
V
-
G
V
L
Y
V
L
D
E
P
S
I
G
L
H
Q
R
D
N
R
R
L
I
E
T
L
T
R
L
R
D
L
G
N
T
L
I
V
V
E
H
D
E
D
T
I
E
-
H
-
A
D
W
I
V
D
I
G
P
G
A
G
E
H
G
G
R
I
V
H
S
G
P
Y
D
E
L
L
R
N
K
D
S
I
T
G
A
Y
L
S
G
R
E
--------
S
----------
I
--
E
I
-----
P
-
A
-
I
---
R
R
S
V
D
P
R
-
R
Q
L
T
V
V
G
A
----
R
----
E
----
H
N
L
R
G
I
D
V
S
F
P
L
G
V
L
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
N
D
I
L
A
A
V
L
A
N
R
L
N
G
A
R
Q
V
P
-------
G
R
------------------
H
T
R
V
T
G
-
L
D
Y
L
D
-
K
L
V
R
V
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
K
I
R
T
L
F
A
A
T
T
E
A
K
V
--
R
G
Y
Q
P
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
T
G
D
G
T
I
K
I
E
------------------------------------------
M
-------------------------------------------
N
F
L
P
----------------------------
D
V
Y
V
P
C
E
V
C
Q
G
A
R
Y
N
R
E
T
L
E
V
H
Y
K
G
K
T
V
S
E
V
L
D
M
S
I
E
E
A
A
E
F
F
E
P
--
I
--------------------------
A
G
V
H
R
Y
L
R
T
L
V
D
V
G
L
G
Y
V
R
L
G
Q
P
A
P
T
L
S
G
G
E
A
Q
R
V
K
L
A
S
E
L
Q
K
R
S
T
G
R
T
V
Y
I
L
D
E
P
T
T
G
L
H
F
D
D
I
R
K
L
L
N
V
I
N
G
L
V
D
-
K
G
N
T
V
I
V
I
E
H
N
L
D
V
I
K
-
T
S
D
W
I
I
D
L
G
P
E
G
G
A
G
G
G
T
V
V
A
Q
G
T
P
E
D
V
A
A
V
P
A
S
Y
T
G
K
F
L
A
E
V
V
------
22
PsiBlast_CBE
85.70
52%
-84
- C2 -
3ZQJ
3
UVRA_MYCTU
C:
[23-970]
-
A
D
R
L
I
V
K
G
A
R
E
H
N
L
R
S
V
D
L
D
L
P
R
D
A
L
I
V
F
T
G
L
S
G
S
G
K
S
S
L
A
F
D
T
I
F
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
G
Q
M
D
K
P
D
V
D
F
I
E
G
L
S
P
A
V
S
I
D
Q
K
S
T
N
R
N
P
R
S
T
V
G
T
I
T
E
V
Y
D
Y
L
R
L
L
Y
A
R
A
G
T
P
H
C
P
T
C
G
E
R
V
A
R
Q
T
P
Q
Q
I
V
D
Q
V
L
A
M
P
------
V
L
A
P
V
V
R
T
R
K
G
E
F
A
D
L
F
D
K
L
N
A
Q
G
Y
S
R
V
R
V
D
G
V
V
H
P
L
T
D
P
P
K
L
K
K
Q
E
K
H
D
I
E
V
V
----------
K
R
R
L
T
D
S
V
E
T
A
L
N
L
A
D
G
I
V
V
---------------------------
L
A
C
P
N
G
H
A
L
A
V
D
D
L
E
P
R
S
F
S
F
N
S
P
Y
G
A
C
P
E
C
S
G
L
G
I
R
K
E
V
D
P
E
L
V
V
P
---------
A
V
A
P
W
-----
S
N
G
----
H
T
A
E
Y
F
T
R
-
M
M
A
G
L
G
E
A
L
G
------------
K
A
R
K
A
I
L
E
-------------------------------
G
A
------------------
D
E
Q
V
H
V
R
Y
RNRYGR
T
R
S
Y
Y
A
--
D
----------------
F
E
-----------------------
G
V
L
A
F
L
Q
R
---------
K
-----
M
-----
S
Q
T
-
E
S
EQ
M
K
E
R
Y
E
G
F
M
R
D
V
P
C
P
V
C
A
G
T
R
L
K
P
E
I
L
A
V
T
L
A
G
HGA-----
K
S
I
A
E
V
C
E
L
S
---
I
A
D
C
A
D
F
L
--
N
A
L
-------
T
L
G
P
R
------
E
----
Q
A
I
A
G
Q
V
L
K
E
I
R
S
R
L
G
F
L
L
D
V
G
L
E
Y
L
S
L
S
R
A
A
A
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
G
L
V
-
G
V
L
Y
V
L
D
E
P
S
I
G
L
H
Q
R
D
N
R
R
L
I
E
T
L
T
R
L
R
D
L
G
N
T
L
I
V
V
E
H
D
E
D
T
I
E
-
H
-
A
D
W
I
V
D
I
G
P
G
A
G
E
H
G
G
R
I
V
H
S
G
P
Y
D
E
L
L
R
N
K
D
S
I
T
G
A
Y
L
S
G
R
E
--------
S
----------
I
--
E
I
-----
P
-
A
-
I
---
R
R
S
V
D
P
R
-
R
Q
L
T
V
V
G
A
----
R
----
E
----
H
N
L
R
G
I
D
V
S
F
P
L
G
V
L
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
N
D
I
L
A
A
V
L
A
N
R
L
N
G
A
R
Q
V
P
-------
G
R
------------------
H
T
R
V
T
G
-
L
D
Y
L
D
-
K
L
V
R
V
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
K
I
R
T
L
F
A
A
T
T
E
A
K
V
--
R
G
Y
Q
P
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
T
G
D
G
T
I
K
I
E
------------------------------------------
M
-------------------------------------------
N
F
L
P
----------------------------
D
V
Y
V
P
C
E
V
C
Q
G
A
R
Y
N
R
E
T
L
E
V
H
Y
K
G
K
T
V
S
E
V
L
D
M
S
I
E
E
A
A
E
F
F
E
P
--
I
--------------------------
A
G
V
H
R
Y
L
R
T
L
V
D
V
G
L
G
Y
V
R
L
G
Q
P
A
P
T
L
S
G
G
E
A
Q
R
V
K
L
A
S
E
L
Q
K
R
S
T
G
R
T
V
Y
I
L
D
E
P
T
T
G
L
H
F
D
D
I
R
K
L
L
N
V
I
N
G
L
V
D
-
K
G
N
T
V
I
V
I
E
H
N
L
D
V
I
K
-
T
S
D
W
I
I
D
L
G
P
E
G
G
A
G
G
G
T
V
V
A
Q
G
T
P
E
D
V
A
A
V
P
A
S
Y
T
G
K
F
L
A
E
V
V
------
23
PsiBlast_CBE
85.37
52%
-80
- C2 -
3ZQJ
3
UVRA_MYCTU
B:
[23-970]
-
A
D
R
L
I
V
K
G
A
R
E
H
N
L
R
S
V
D
L
D
L
P
R
D
A
L
I
V
F
T
G
L
S
G
S
G
K
S
S
L
A
F
D
T
I
F
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
G
Q
M
D
K
P
D
V
D
F
I
E
G
L
S
P
A
V
S
I
D
Q
K
S
T
N
R
N
P
R
S
T
V
G
T
I
T
E
V
Y
D
Y
L
R
L
L
Y
A
R
A
G
T
P
H
C
P
T
C
G
E
R
V
A
R
Q
T
P
Q
Q
I
V
D
Q
V
L
A
M
P
E
G
T
R
F
L
V
L
A
P
V
V
R
T
R
K
G
E
F
A
D
L
F
D
K
L
N
A
Q
G
Y
S
R
V
R
V
D
G
V
V
H
P
L
T
D
P
P
K
L
K
K
Q
E
K
H
D
I
E
V
V
V
D
--------
K
R
R
L
T
D
S
V
E
T
A
L
N
L
A
D
G
I
V
V
L
----------------------
F
S
E
K
L
A
C
P
N
G
H
A
L
A
V
D
D
L
E
P
R
S
F
S
F
N
S
P
Y
G
A
C
P
E
C
S
G
L
G
I
R
K
E
V
D
P
E
L
V
V
P
-----------
A
P
W
-----
S
N
G
----
H
T
A
E
Y
F
T
R
-
M
M
A
G
L
G
E
A
L
G
F
D
V
D
T
P
W
R
K
L
P
A
K
A
R
K
A
I
L
E
-------------------------------
G
A
------------------
D
E
Q
V
H
V
R
Y
R
N
RYG
R
T
R
S
YY
A
--
D
----------------
F
E
-----------------------
G
V
L
A
F
L
Q
R
---------
K
-----
M
-----
S
Q
T
-
E
S
EQ
M
K
E
R
Y
E
G
F
M
R
D
V
P
C
P
V
C
A
G
T
R
L
K
P
E
I
L
A
V
T
L
A
G
ESKGEHGA
K
S
I
A
E
V
C
E
L
S
---
I
A
D
C
A
D
F
L
--
N
A
L
-------
T
L
G
P
R
------
E
----
Q
A
I
A
G
Q
V
L
K
E
I
R
S
R
L
G
F
L
L
D
V
G
L
E
Y
L
S
L
S
R
A
A
A
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
G
L
V
-
G
V
L
Y
V
L
D
E
P
S
I
G
L
H
Q
R
D
N
R
R
L
I
E
T
L
T
R
L
R
D
L
G
N
T
L
I
V
V
E
H
D
E
D
T
I
E
-
H
-
A
D
W
I
V
D
I
G
P
G
A
G
E
H
G
G
R
I
V
H
S
G
P
Y
D
E
L
L
R
N
K
D
S
I
T
G
A
Y
L
S
G
R
E
--------
S
----------
I
--
E
I
-----
P
-
A
-
I
---
R
R
S
V
D
P
R
-
R
Q
L
T
V
V
G
A
----
R
----
E
----
H
N
L
R
G
I
D
V
S
F
P
L
G
V
L
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
N
D
I
L
A
A
V
L
A
N
R
L
N
G
A
R
Q
V
P
-------
G
R
------------------
H
T
R
V
T
G
-
L
D
Y
L
D
-
K
L
V
R
V
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
K
I
R
T
L
F
A
A
T
T
E
A
K
V
--
R
G
Y
Q
P
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
T
G
D
G
T
I
K
I
E
------------------------------------------
M
-------------------------------------------
N
F
L
P
----------------------------
D
V
Y
V
P
C
E
V
C
Q
G
A
R
Y
N
R
E
T
L
E
V
H
Y
K
G
K
T
V
S
E
V
L
D
M
S
I
E
E
A
A
E
F
F
E
P
--
I
--------------------------
A
G
V
H
R
Y
L
R
T
L
V
D
V
G
L
G
Y
V
R
L
G
Q
P
A
P
T
L
S
G
G
E
A
Q
R
V
K
L
A
S
E
L
Q
K
R
S
T
G
R
T
V
Y
I
L
D
E
P
T
T
G
L
H
F
D
D
I
R
K
L
L
N
V
I
N
G
L
V
D
-
K
G
N
T
V
I
V
I
E
H
N
L
D
V
I
K
-
T
S
D
W
I
I
D
L
G
P
E
G
G
A
G
G
G
T
V
V
A
Q
G
T
P
E
D
V
A
A
V
P
A
S
Y
T
G
K
F
L
A
E
V
V
------
21
PsiBlast_CBE
85.36
52%
-81
- C2 -
3ZQJ
2
UVRA_MYCTU
E:
[23-970]
-
A
D
R
L
I
V
K
G
A
R
E
H
N
L
R
S
V
D
L
D
L
P
R
D
A
L
I
V
F
T
G
L
S
G
S
G
K
S
S
L
A
F
D
T
I
F
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
G
Q
M
D
K
P
D
V
D
F
I
E
G
L
S
P
A
V
S
I
D
Q
K
S
T
N
R
N
P
R
S
T
V
G
T
I
T
E
V
Y
D
Y
L
R
L
L
Y
A
R
A
G
T
P
H
C
P
------
A
R
Q
T
P
Q
Q
I
V
D
Q
V
L
A
M
P
E
G
T
R
F
L
V
L
A
P
V
V
R
T
R
K
G
E
F
A
D
L
F
D
K
L
N
A
Q
G
Y
S
R
V
R
V
D
G
V
V
H
P
L
T
D
P
P
K
L
K
K
Q
E
K
H
D
I
E
V
V
V
D
--------
K
R
R
L
T
D
S
V
E
T
A
L
N
L
A
D
G
I
V
V
L
E
F
V
DH---------------------
L
A
C
P
N
G
H
A
L
A
V
D
D
L
E
P
R
S
F
S
F
N
S
P
Y
G
A
C
P
E
C
S
G
L
G
I
R
K
E
V
D
P
E
L
V
V
P
D
P
D
R
T
L
A
Q
G
A
V
A
P
W
-----
S
N
G
----
H
T
A
E
Y
F
T
R
-
M
M
A
G
L
G
E
A
L
G
F
D
V
D
T
P
W
--
L
P
A
K
A
R
K
A
I
L
E
-------------------------------
G
A
------------------
D
E
QVHVRYRNRYGRTR
S
Y
Y
A
--
D
----------------
F
E
-----------------------
G
V
L
A
F
L
Q
R
---------
K
-----
M
-----
S
Q
T
-
E
S
EQ
M
K
E
R
Y
E
G
F
M
R
DVP
C
P
V
C
A
G
T
R
L
K
P
E
I
L
A
V
T
L
A
-KGEHGA--
K
S
I
A
E
V
C
E
L
S
---
I
A
D
C
A
D
F
L
--
N
A
L
-------
T
L
G
P
R
------
E
----
Q
A
I
A
G
Q
V
L
K
E
I
R
S
R
L
G
F
L
L
D
V
G
L
E
Y
L
S
L
S
R
A
A
A
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
G
L
V
-
G
V
L
Y
V
L
D
E
P
S
I
G
L
H
Q
R
D
N
R
R
L
I
E
T
L
T
R
L
R
D
L
G
N
T
L
I
V
V
E
H
D
E
D
T
I
E
-
H
-
A
D
W
I
V
D
I
G
P
G
A
G
E
H
G
G
R
I
V
H
S
G
P
Y
D
E
L
L
R
N
K
D
S
I
T
G
A
Y
L
S
G
R
E
--------
S
----------
I
--
E
I
-----
P
-
A
-
I
---
R
R
S
V
D
P
R
-
R
Q
L
T
V
V
G
A
----
R
----
E
----
H
N
L
R
G
I
D
V
S
F
P
L
G
V
L
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
N
D
I
L
A
A
V
L
A
N
R
L
N
G
A
R
Q
V
P
-------
G
R
------------------
H
T
R
V
T
G
-
L
D
Y
L
D
-
K
L
V
R
V
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
K
I
R
T
L
F
A
A
T
T
E
A
K
V
--
R
G
Y
Q
P
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
T
G
D
G
T
I
K
I
E
------------------------------------------
M
-------------------------------------------
N
F
L
P
----------------------------
D
V
Y
V
P
C
E
V
C
Q
G
A
R
Y
N
R
E
T
L
E
V
H
Y
K
G
K
T
V
S
E
V
L
D
M
S
I
E
E
A
A
E
F
F
E
P
--
I
--------------------------
A
G
V
H
R
Y
L
R
T
L
V
D
V
G
L
G
Y
V
R
L
G
Q
P
A
P
T
L
S
G
G
E
A
Q
R
V
K
L
A
S
E
L
Q
K
R
S
T
G
R
T
V
Y
I
L
D
E
P
T
T
G
L
H
F
D
D
I
R
K
L
L
N
V
I
N
G
L
V
D
-
K
G
N
T
V
I
V
I
E
H
N
L
D
V
I
K
-
T
S
D
W
I
I
D
L
G
P
E
G
G
A
G
G
G
T
V
V
A
Q
G
T
P
E
D
V
A
A
V
P
A
S
Y
T
G
K
F
L
A
E
V
V
------
118
HHSearch
77.12
44%
-80
* C2 *
2VF7
4
?
A:
[12-841]
D
G
G
F
V
Q
V
R
G
A
R
Q
H
N
L
K
D
I
S
V
K
V
P
R
D
A
L
V
V
F
T
G
V
S
G
S
G
K
S
S
L
A
F
G
T
L
Y
A
E
A
Q
R
R
Y
L
E
S
V
S
P
Y
A
R
R
L
F
N
Q
A
G
V
P
D
V
D
A
I
D
G
L
P
P
A
V
A
L
Q
Q
A
R
G
T
P
T
A
R
S
S
V
G
S
V
T
T
L
S
N
L
L
R
M
L
Y
S
R
A
G
D
Y
P
P
G
-
Q
G
I
----------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
A
E
G
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
S
M
V
P
D
P
S
L
T
I
R
E
R
A
V
A
A
W
-----
P
Q
A
W
-------
G
G
Q
--
N
Q
R
D
I
L
V
T
L
G
I
D
V
D
V
P
W
R
E
L
P
E
E
T
R
H
W
I
L
F
-------------------------------
T
D
------------------
E
Q
-----------------
P
--
V
----------------
V
P
V
Y
P
GLT
P
A
E
T
Q
R
A
L
K
K
KMEPS
Y
M
G
T
F
S
S
A
R
R
H
V
L
H
T
F
A
NT
E
-----
S
-----
A
S
M
-
K
K
--
R
V
Q
G
Y
M
I
S
E
E
---
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
A
G
--------
L
D
I
T
E
L
S
R
L
P
---
L
A
R
V
S
E
L
L
--
R
P
Y
A
E
-----
E
R
E
P
G
HAERVK
N
RPE
Q
A
I
A
L
Q
R
M
A
A
D
L
V
K
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
L
F
-
G
V
V
Y
V
L
D
E
P
S
A
G
L
H
P
A
D
T
E
A
L
L
S
A
L
E
N
L
K
R
G
G
N
S
L
F
V
V
E
H
D
L
D
V
I
R
-
R
-
A
D
W
L
V
D
V
G
P
E
A
G
E
K
G
G
E
I
L
Y
S
G
P
P
E
G
L
K
H
V
P
E
S
Q
T
G
Q
Y
L
F
A
D
R
--------
H
----------
T
--
E
------
P
-
H
-
T
---
P
R
E
P
--
A
-
G
W
L
E
L
N
G
V
----
T
----
R
----
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
A
H
F
G
Q
------------
G
S
-------------------
A
R
L
G
G
D
L
A
Q
I
T
-
R
L
V
R
V
D
Q
K
P
I
G
R
T
P
R
S
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
K
--
R
G
Y
N
A
G
R
F
S
F
N
V
K
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
E
------------------------------------------
L
-------------------------------------------
L
F
L
P
----------------------------
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
D
--
E
--------------------------
S
A
I
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
G
R
G
G
T
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
R
Q
L
V
K
L
V
D
-
A
G
N
T
V
I
A
V
E
H
K
M
Q
V
V
A
-
A
S
D
W
V
L
D
I
G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
Q
A
A
G
S
V
T
A
P
Y
L
R
A
A
L
R
-----
26
PsiBlast_CBE
66.84
40%
-77
- C2 -
2VF7
4
?
B:
[142-841]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
S
M
V
P
D
P
S
L
T
I
R
E
R
A
V
A
A
W
PQA
W
G
G
Q
N
Q
R
D
I
L
V
T
L
G
I
--------------
D
V
D
V
P
W
R
E
L
P
E
E
T
R
H
W
I
L
F
TD
E
Q
P
V
V
P
V
Y
P
GLT
P
A
E
T
Q
R
A
L
K
K
KMEPS
Y
M
G
T
------------------
F
S
-----------------
S
--
A
----------------
R
R
-----------------------
H
V
L
H
T
F
A
N
---------
T
-----
E
-----
S
A
S
M
K
K
--
R
V
Q
G
Y
M
I
S
E
E
---
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
A
G
--------
L
D
I
T
E
L
S
R
L
P
L
A
R
V
S
E
L
L
R
P
Y
AE
E
R
E
P
G
H
A
E
R
V
K
N
R
P
E
------
Q
----
A
I
A
L
Q
R
M
A
A
D
L
V
K
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
L
F
-
G
V
V
Y
V
L
D
E
P
S
A
G
L
H
P
A
D
T
E
A
L
L
S
A
L
E
N
L
K
R
G
G
N
S
L
F
V
V
E
H
D
L
D
V
I
R
-
R
-
A
D
W
L
V
D
V
G
P
E
A
G
E
K
G
G
E
I
L
Y
S
G
P
P
E
G
L
K
H
V
P
E
S
Q
T
G
Q
Y
L
F
A
D
R
--------
H
----------
T
--
E
------
P
-
H
-
T
---
P
R
E
P
--
A
-
G
W
L
E
L
N
G
V
----
T
----
R
----
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
-------
A
H
F
-------
G
Q
G-----------------
S
A
R
L
G
G
D
L
A
Q
I
T
-
R
L
V
R
V
D
Q
K
P
I
G
R
T
P
R
S
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
K
--
R
G
Y
N
A
G
R
F
S
F
N
V
K
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
------------------------------------------------------------------------------------------
P
----------------------------
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
D
--
E
--------------------------
S
A
I
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
G
R
G
G
T
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
R
Q
L
V
K
L
V
D
-
A
G
N
T
V
I
A
V
E
H
K
M
Q
V
V
A
-
A
S
D
W
V
L
D
I
G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
Q
A
A
G
S
V
T
A
P
Y
L
R
A
A
L
R
-----
4
PsiBlast_PDB
66.29
40%
-75
- C2 -
2VF7
4
?
A:
[142-841]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
S
M
V
P
D
P
S
L
T
I
R
E
R
A
V
A
A
W
PQA
W
G
G
Q
N
Q
R
D
I
L
V
T
L
G
I
--------------
D
V
D
V
P
W
R
E
L
P
E
E
T
R
H
W
I
L
F
TD
E
Q
P
V
V
P
V
Y
P
GLT
P
A
E
T
Q
R
A
L
K
K
KMEPS
Y
M
G
T
------------------
F
S
-----------------
S
--
A
----------------
R
R
-----------------------
H
V
L
H
T
F
A
N
---------
T
-----
E
-----
S
A
S
M
K
K
--
R
V
Q
G
Y
M
I
S
E
E
---
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
A
G
--------
L
D
I
T
E
L
S
R
L
P
L
A
R
V
S
E
L
L
R
P
Y
AE
E
R
E
P
G
HAERV
K
N
R
P
E
------
Q
----
A
I
A
L
Q
R
M
A
A
D
L
V
K
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
L
F
-
G
V
V
Y
V
L
D
E
P
S
A
G
L
H
P
A
D
T
E
A
L
L
S
A
L
E
N
L
K
R
G
G
N
S
L
F
V
V
E
H
D
L
D
V
I
R
-
R
-
A
D
W
L
V
D
V
G
P
E
A
G
E
K
G
G
E
I
L
Y
S
G
P
P
E
G
L
K
H
V
P
E
S
Q
T
G
Q
Y
L
F
A
D
R
--------
H
----------
T
--
E
------
P
-
H
-
T
---
P
R
E
P
--
A
-
G
W
L
E
L
N
G
V
----
T
----
R
----
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
-------
A
H
F
-------
G
Q
G-----------------
S
A
R
L
G
G
D
L
A
Q
I
T
-
R
L
V
R
V
D
Q
K
P
I
G
R
T
P
R
S
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
K
--
R
G
Y
N
A
G
R
F
S
F
N
V
K
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
E
------------------------------------------
L
-------------------------------------------
L
F
L
P
----------------------------
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
D
--
E
--------------------------
S
A
I
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
G
R
G
G
T
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
R
Q
L
V
K
L
V
D
-
A
G
N
T
V
I
A
V
E
H
K
M
Q
V
V
A
-
A
S
D
W
V
L
D
I
G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
Q
A
A
G
S
V
T
A
P
Y
L
R
A
A
L
R
-----
24
PsiBlast_CBE
65.36
40%
-78
- C2 -
2VF8
9
?
B:
[142-841]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
S
M
V
P
D
P
S
L
T
I
R
E
R
A
V
A
A
W
PQA
W
G
G
Q
N
Q
R
D
I
L
V
T
L
G
I
--------------
D
V
D
V
P
W
R
E
L
P
E
E
T
R
H
W
I
L
F
TDEQPV
V
P
V
Y
P
GLT
P
A
E
T
Q
R
A
L
K
K
KMEPS
Y
M
G
T
------------------
F
S
-----------------
S
--
A
----------------
R
R
-----------------------
H
V
L
H
T
F
A
N
---------
T
-----
E
-----
S
A
S
M
K
K
--
R
V
Q
G
Y
M
I
S
E
E
---
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
A
G
--------
L
D
I
T
E
L
S
R
L
P
L
A
R
V
S
E
L
L
R
P
Y
AE
E
R
E
P
G
H
A
E
R
V
K
N
R
P
E
------
Q
----
A
I
A
L
Q
R
M
A
A
D
L
V
K
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
L
F
-
G
V
V
Y
V
L
D
E
P
S
A
G
L
H
P
A
D
T
E
A
L
L
S
A
L
E
N
L
K
R
G
G
N
S
L
F
V
V
E
H
D
L
D
V
I
R
-
R
-
A
D
W
L
V
D
V
G
P
E
A
G
E
K
G
G
E
I
L
Y
S
G
P
P
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G
L
K
H
V
P
E
S
Q
T
G
Q
Y
L
F
A
D
R
--------
H
----------
T
--
E
------
P
-
H
-
T
---
P
R
E
P
--
A
-
G
W
L
E
L
N
G
V
----
T
----
R
----
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
-------
A
H
F
-------
G
Q
PVNPDP
E
D
D
E
DPADHTAG
S
A
R
L
G
G
D
L
A
Q
I
T
-
R
L
V
R
V
D
Q
K
P
I
G
R
T
P
R
S
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
K
--
R
G
Y
N
A
G
R
F
S
F
N
V
K
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
E
------------------------------------------
L
-------------------------------------------
L
F
L
P
----------------------------
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
D
--
E
--------------------------
S
A
I
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
G
R
G
G
T
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
R
Q
L
V
K
L
V
D
-
A
G
N
T
V
I
A
V
E
H
K
M
Q
V
V
A
-
A
S
D
W
V
L
D
I
G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
Q
A
A
G
S
V
T
A
P
Y
L
R
A
A
L
R
-----
5
PsiBlast_PDB
65.23
40%
-74
- C2 -
2VF8
7
?
A:
[142-841]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
S
M
V
P
D
P
S
L
T
I
R
E
R
A
V
A
A
W
PQA
W
G
G
Q
N
Q
R
D
I
L
V
T
L
G
I
--------------
D
V
D
V
P
W
R
E
L
P
E
E
T
R
H
W
I
L
F
TD
E
Q
P
V
V
P
V
YPGLT
P
A
E
T
Q
R
A
L
K
K
KMEPS
Y
M
G
T
------------------
F
S
-----------------
S
--
A
----------------
R
R
-----------------------
H
V
L
H
T
F
A
N
---------
T
-----
E
-----
S
A
S
M
K
K
--
R
V
Q
G
Y
M
I
S
E
E
---
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
A
G
--------
L
D
I
T
E
L
S
R
L
P
L
A
R
V
S
E
L
L
R
P
Y
AE
E
R
E
P
G
HAERV
K
N
R
P
E
------
Q
----
A
I
A
L
Q
R
M
A
A
D
L
V
K
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
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L
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L
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L
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L
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S
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L
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-
G
V
V
Y
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L
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L
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L
L
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A
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L
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G
N
S
L
F
V
V
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H
D
L
D
V
I
R
-
R
-
A
D
W
L
V
D
V
G
P
E
A
G
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K
G
G
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I
L
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G
P
P
E
G
L
K
H
V
P
E
S
Q
T
G
Q
Y
L
F
A
D
-----------------------
E
------
P
-
H
-
T
---
P
R
E
P
--
A
-
G
W
L
E
L
N
G
V
----
T
----
R
----
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
-------
A
H
F
-------
G
Q
G-----------------
S
A
R
L
G
G
D
L
A
Q
I
T
-
R
L
V
R
V
D
Q
K
P
I
G
R
T
P
R
S
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
K
--
R
G
Y
N
A
G
R
F
S
F
N
V
K
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
------------------------------------------------------------------------------------------
P
----------------------------
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
D
--
E
--------------------------
S
A
I
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
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L
R
R
S
G
R
G
G
T
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
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L
Q
R
Q
L
V
K
L
V
D
-
A
G
N
T
V
I
A
V
E
H
K
M
Q
V
V
A
-
A
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D
W
V
L
D
I
G
P
G
A
G
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D
G
G
R
L
V
A
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G
T
P
A
E
V
A
Q
A
A
G
S
V
T
A
P
Y
L
R
A
A
L
R
-----
25
PsiBlast_CBE
64.98
40%
-72
- C2 -
2VF7
5
?
C:
[142-841]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
S
M
V
P
D
P
S
L
T
I
R
E
R
A
V
A
A
W
PQA
W
G
G
Q
N
Q
R
D
I
L
V
T
L
G
I
--------------
D
V
D
V
P
W
R
E
L
P
E
E
T
R
H
W
I
L
F
TD
E
Q
P
V
V
P
V
Y
P
GLT
P
A
E
T
Q
R
A
L
K
K
KMEPS
Y
M
G
T
------------------
F
S
-----------------
S
--
A
----------------
R
R
-----------------------
H
V
L
H
T
F
A
N
---------
T
-----
E
-----
S
A
S
M
K
K
--
R
V
Q
G
Y
M
I
S
E
E
---
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
A
G
--------
L
D
I
T
E
L
S
R
L
P
L
A
R
V
S
E
L
L
R
P
Y
AE
E
R
E
P
G
HA
E
R
V
K
N
R
P
E
------
Q
----
A
I
A
L
Q
R
M
A
A
D
L
V
K
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
L
F
-
G
V
V
Y
V
L
D
E
P
S
A
G
L
H
P
A
D
T
E
A
L
L
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A
L
E
N
L
K
R
G
G
N
S
L
F
V
V
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D
L
D
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I
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-
R
-
A
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P
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A
G
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G
G
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L
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P
P
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G
L
K
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P
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S
Q
T
G
Q
Y
L
F
A
D
R
--------
H
----------
T
--
E
------
P
-
H
-
T
---
P
R
E
P
--
A
-
G
W
L
E
L
N
G
V
----
T
----
R
----
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
-------
A
H
F
-------
G
-------------------
S
A
R
L
G
G
D
L
A
Q
I
T
-
R
L
V
R
V
D
Q
K
P
I
G
R
T
P
R
S
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
K
--
R
G
Y
N
A
G
R
F
S
F
N
V
K
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
E
------------------------------------------
L
-------------------------------------------
L
F
L
P
----------------------------
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
D
--
E
--------------------------
S
A
I
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
G
R
G
G
T
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
R
Q
L
V
K
L
V
D
-
A
G
N
T
V
I
A
V
E
H
K
M
Q
V
V
A
-
A
S
D
W
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L
D
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G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
Q
A
A
G
S
V
T
A
P
Y
L
R
A
A
L
R
-----
128
HHSearch
55.31
37%
-68
- C2 -
2R6F
3
?
A:
[628-954]
--
R
W
L
E
V
V
G
A
R
E
H
N
L
K
N
V
S
V
K
I
P
L
G
T
F
V
A
V
T
G
V
S
G
S
G
K
S
T
L
V
N
E
V
L
Y
K
A
L
A
Q
K
L
H
R
A
-------
K
A
K
P
G
E
H
R
D
I
R
G
L
E
H
L
D
K
V
I
D
I
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
D
I
R
D
V
F
A
S
T
N
E
A
K
-------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
G
Y
K
K
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
H
G
D
G
I
I
K
-
I
E
M
H
---------------------------------------
F
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
V
Y
V
P
---
C
E
V
C
H
G
K
R
Y
N
R
E
T
L
E
V
T
Y
K
G
--------
K
N
I
A
E
V
L
D
M
T
---
V
E
D
A
L
D
F
F
--
A
S
I
P
-------------------------------
K
I
K
R
K
L
E
T
L
Y
D
V
G
L
G
Y
M
K
L
G
Q
P
A
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T
L
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G
G
E
A
Q
R
V
K
L
A
A
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L
H
R
R
S
N
G
R
T
L
Y
I
L
D
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P
T
T
G
L
H
V
D
D
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A
R
L
L
D
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L
H
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L
V
D
N
G
D
T
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L
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N
L
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A
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K
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H
T
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R
Y
L
K
P
I
L
--------
E
----------
R
--
D
R
-----
A
-
R
-
M
---
Q
A
R
Y
--
E
-
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
122
HHSearch
54.70
32%
-78
- C2 -
2VF7
3
?
A:
[12-485]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--
G
-
G
F
V
Q
V
R
G
A
----
R
----
Q
----
H
N
L
K
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I
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R
D
A
L
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V
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S
G
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L
A
F
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T
L
Y
A
E
A
Q
R
R
Y
L
E
S
V
S
P
Y
ARRLFNQ
A
G
------------------
V
P
D
V
D
A
-
I
D
G
L
P
-
P
A
V
A
L
Q
Q
A
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G
T
P
T
A
R
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V
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L
S
N
L
L
R
M
L
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R
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Y
P
P
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G
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Y
A
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N
T
P
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G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
EDSMVPDPSLTIRERAVAAWPQA
W
G
G
Q
N
Q
R
D
I
L
V
T
L
GIDVD
V
PWRELP
E
E
T
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H
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FTD
E
Q
P
V
V
P
V
Y
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GLT
P
A
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KMEP
S
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T
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A
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R
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L
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T
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A
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A
S
M
K
K
R
V
Q
G
Y
M
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S
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E
C
P
L
C
H
G
K
R
L
R
Q
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A
L
N
V
T
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A
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L
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I
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L
S
R
L
P
L
A
R
V
S
E
L
L
R
P
--
Y
AEEREPGHAERVKNRPE
Q
A
I
A
L
Q
R
M
A
A
D
L
V
K
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
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S
T
P
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P
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L
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R
L
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L
A
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L
Y
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L
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H
V
P
E
S
Q
T
G
Q
Y
L
F
A
D
R
H
T
E
P
H
T
123
HHSearch
44.59
25%
-58
- C2 -
3BK7
2
?
A:
[211-547]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
V
K
E
L
E
L
E
N
-
V
L
D
R
E
L
H
Q
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
A
H
---
F
Y
F
F
D
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P
S
S
Y
L
D
I
R
Q
R
L
K
V
A
R
V
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R
R
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A
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K
A
V
L
V
V
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V
L
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L
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V
Y
G
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G
V
Y
G
I
F
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P
K
G
T
R
N
G
I
N
----
E
F
L
Q
G
Y
L
K
D
E
N
VRFR----
P
----------
Y
--
E
I
R
F
TKL
S
E
R
-
V
---
D
V
E
R
--
E
-
T
L
V
E
Y
P
R
L
----
V
----
K
D
YGS
F
K
L
E
V
E
P
G
E
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R
K
G
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V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
----------------------------------------
E
E
P
T
E
G
-
K
-------
V
E
W
D
L
T
-
V
---------
A
Y
K
---
P
Q
Y
I
-----------------
K
A
E
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
G
T
V
Y
E
L
L
S
K
I
D
S
S
--
K
L
--------------------------------
N
S
N
F
Y
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T
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L
L
K
P
L
G
I
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L
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Y
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A
A
T
L
L
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---
A
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E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
K
T
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
I
V
F
E
G
E
P
G
R
H
G
R
A
L
P
P
M
G
M
R
E
G
M
N
R
F
L
A
S
V
G
I
T
F
R
R
D
P
D
S
G
R
P
R
A
125
HHSearch
43.56
25%
-57
- C2 -
1YQT
4
?
A:
[143-477]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
A
L
E
L
E
N
-
V
L
E
R
E
I
Q
H
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
N
A
T
---
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
Q
R
L
N
A
A
R
A
I
R
R
L
S
E
E
G
K
S
V
L
V
V
E
H
D
L
A
V
L
D
-
Y
L
S
D
I
I
H
V
V
Y
G
E
P
G
V
Y
G
I
F
S
Q
P
K
G
T
R
N
G
I
N
----
E
F
L
R
G
Y
L
K
D
E
N
VRFRP
Y
E
I
K
----------
F
--
T
K
T----
G
-
E
R
V
---
E
I
E
R
--
E
-
T
L
V
T
Y
P
R
L
----
V
K
D
YG
S
----
F
R
L
E
V
E
P
G
E
I
K
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
----------------------------------------
E
E
P
T
E
G
--------
K
I
E
W
D
L
T
V
----------
A
Y
K
---
P
Q
Y
I
K
A
-----------------
D
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
G
T
V
Y
E
L
L
S
K
I
D
A
S
K
L
--------------------------
N
S
N
F
Y
K
T
E
L
L
K
P
L
G
I
I
D
L
-
Y
D
R
E
V
N
E
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
---
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
K
T
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
M
V
F
E
G
E
P
G
K
Y
G
R
A
L
P
P
M
G
M
R
E
G
M
N
R
F
L
A
S
I
G
I
T
F
R
R
D
P
D
T
G
R
P
R
A
7
PsiBlast_PDB
41.37
44%
-79
- C4 -
4DFC
-
UVRA_ECOLI
B:
[128-240]
--------------------------------------------------------------------------------------------------------------------------------
M
A
S
T
V
S
Q
M
V
D
N
V
L
S
Q
P
E
G
K
R
L
M
L
L
A
P
I
I
K
E
R
K
G
E
H
T
K
T
L
E
N
L
A
S
Q
G
Y
I
R
A
R
I
D
G
E
V
C
D
L
S
D
P
P
K
L
E
L
Q
K
K
H
T
I
E
V
V
V
D
R
F
K
V
R
--
L
T
Q
R
L
A
E
S
F
E
T
A
L
E
L
S
G
G
T
A
V
V
A
D
M
--
D
D
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
124
HHSearch
41.18
22%
-33
- C2 -
3J16
2
RLI1_YEAST
B:
[204-559]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
I
K
I
L
Q
L
E
N
-
V
L
K
R
D
I
E
K
L
S
G
G
E
L
Q
R
F
A
I
G
M
S
C
V
Q
E
A
D
---
V
Y
M
F
D
E
P
S
S
Y
L
D
V
K
Q
R
L
N
A
A
Q
I
I
R
S
L
L
A
P
T
K
Y
V
I
C
V
E
H
D
L
S
V
L
D
Y
L
-
S
D
F
V
C
I
I
Y
G
V
P
S
V
Y
-
G
V
V
T
L
P
A
S
V
R
E
G
I
-------
N
I
F
L
D
G
H
I
--------
P
AENLRFRT
E
A
L
Q
F
R
I
AD---
A
-
T
-
E
DLQ
N
D
S
A
--
S
-
R
A
F
S
Y
P
S
L
K
K
T
Q
G
----
D
----
F
V
L
N
V
E
E
G
E
F
S
D
S
E
I
L
V
M
M
G
E
N
G
T
G
K
T
T
L
I
K
L
L
A
G
A
----------------------------------------
L
K
P
D
E
G
-
Q
D
I
P
K
L
N
V
S
M
K
P
Q
K
I
A
-------------------
P
------------------
K
F
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
V
R
Q
L
F
F
K
K
I
R
G
Q
---
F
L
N
-----------------------------
P
--
Q
F
Q
T
D
V
V
K
P
L
R
I
D
D
-
I
I
D
Q
E
V
Q
H
L
S
G
G
E
L
Q
R
V
A
I
V
L
A
L
G
I
P
---
A
D
I
Y
L
I
D
E
P
S
A
Y
L
D
S
E
Q
R
I
I
C
S
K
V
I
R
R
F
I
L
H
N
K
K
T
A
F
I
V
E
H
D
F
I
M
A
T
Y
L
A
D
K
V
I
V
F
E
G
----
I
P
S
K
N
A
H
A
R
A
P
E
S
L
L
T
G
C
N
R
F
L
K
N
L
N
V
T
F
R
R
D
P
N
S
F
144
Fugue
40.93
40%
-62
* C4 *
4DFC
-
UVRA_ECOLI
B:
[128-250]
--------------------------------------------------------------------------------------------------------------------------------
M
A
S
T
V
S
Q
M
V
D
N
V
L
S
Q
P
E
G
K
R
L
M
L
L
A
P
I
I
K
E
R
K
G
E
H
T
K
T
L
E
N
L
A
S
Q
G
Y
I
R
A
R
I
D
G
E
V
C
D
L
S
D
P
P
K
L
E
L
Q
K
K
H
T
I
E
V
V
V
D
R
F
K
V
R
--
L
T
Q
R
L
A
E
S
F
E
T
A
L
E
L
S
G
G
T
A
V
V
A
D
M
--
D
D
P
K
A
E
E
L
L
F
S
A
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------