@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0402: (2015-12-01 )
MIFAFPGQGSQFVGMGRDLYSQFSVAKQVFDEVDSILGRKLSHLIFNGPVEELTITENAQPAITAVSIATLRVMEHVFGKSLLSDHDVKYVCGHSVGEYTALCAAGALTLESTVKLLKARSEAMHKASLKCKGGMVALLGAEISEVEDILESAQIDEIYGIANDNGGGQVVVSGTAEALEILPGLFKNSSVRKLIKLQVSGPFHSSLMRPADEKILEFLESIDITHPSIPFVSNVTAKEESNPETIKILLAKQIVSRVKWREMVLHMASSGINEFVEIGPNKVLSNLVKRIDQSISTKNIGSISDIDSFFNRSPVLTVENLEVSLS
Atome Classification :
(21 SA)
.........10........20........30........40........50........60.....-...70........80........90........100.......110.......120.......130.......140.....-..150.-......160.......170-------.........180.......190-.........200.......210.......220.......230.......240.......250.......260.....-----..270.......280.......290.......300.......310.......320....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
I
F
AFPGQGS
Q
F
V
GM
G
R
D
L
Y
S
Q
F
S
V
A
K
Q
V
F
D
E
V
D
S
I
L
G
R
K
L
S
H
L
IFNGPV
E
E
L
T
ITENAQP
A
I
T
A
V
-
S
I
A
T
L
R
V
M
E
H
V
F
G
K
S
LLSDHD
V
K
Y
V
CGHSVG
E
Y
T
A
L
C
AAG
A
L
T
L
E
S
T
V
K
L
L
K
A
R
S
E
A
M
H
KA
S
L
KCKG
G
M
V
A
L
LGA
E
I
S
E
V
E
-
D
I
L
E
SA-QI
D
E
I
Y
G
IANDNGG
G
Q
V
---------
V
VSG
T
A
E
A
L
E
I
L
P
G
L
FK
N
S
S
---
V
R
K
L
I
K
L
Q
VSGP
F
H
S
S
LMRP
A
D
E
K
I
L
E
F
L
E
SIDITHPSIPFVSNVTAKEESNP
E
T
I
K
I
L
L
A
K
Q
I
V
S
R
V
K
W
R
E
M
V
L
H
M
-----
A
S
S
G
I
N
E
F
V
EIG
P
N
K
V
L
S
N
L
V
K
R
I
D
Q
S
ISTKNIGS
I
S
D
I
D
S
F
FNRSP
V
L
T
V
E
N
L
E
V
SLS
27
HHSearch
94.47
44%
-103
- C1 -
3QAT
2
?
A:
[7-317]
A
A
F
T
F
P
G
Q
G
S
Q
L
I
G
M
G
K
V
L
T
E
Q
F
V
A
A
R
M
V
F
E
E
V
D
D
A
L
S
E
K
L
S
D
I
I
F
E
G
P
A
D
V
L
T
L
T
A
N
A
Q
P
A
L
M
A
V
-
S
M
A
V
I
R
V
M
E
Q
L
-
G
L
N
V
E
--
K
K
V
K
F
V
A
G
H
S
L
G
E
Y
S
A
L
C
A
A
G
T
F
S
L
T
D
T
A
R
L
L
R
I
R
G
N
A
M
Q
A
A
V
A
V
G
E
G
S
M
A
A
L
I
G
L
D
E
K
D
V
E
-
E
I
C
E
I
V
-
A
E
E
G
L
C
Q
I
A
N
D
N
G
G
G
Q
I
---------
V
I
S
G
E
A
K
A
V
E
T
A
V
E
V
A
S
Q
K
G
---
A
K
R
A
V
L
L
P
V
S
A
P
F
H
S
A
L
M
Q
P
A
A
N
A
M
K
N
A
L
L
T
V
N
K
T
A
P
I
V
P
L
I
A
N
V
S
V
I
P
E
S
D
P
E
R
I
V
S
L
L
V
Q
Q
V
T
G
R
V
R
W
R
E
T
I
E
W
I
-----
S
A
N
G
V
N
T
L
F
E
I
G
S
G
K
V
L
T
G
L
A
R
R
I
N
K
D
I
K
A
L
T
V
G
T
A
E
E
I
E
A
A
L
R
V
L
G
V
-----------
21
PsiBlast_CBE
93.56
44%
-101
- C1 -
3QAT
2
?
B:
[9-311]
--
F
T
F
P
G
Q
G
S
Q
L
I
G
M
G
K
V
L
T
E
Q
F
V
A
A
R
M
V
F
E
E
V
D
D
A
L
S
E
K
L
S
D
I
I
F
E
G
P
A
D
V
L
T
L
T
A
N
A
Q
P
A
L
M
A
V
-
S
M
A
V
I
R
V
M
E
Q
L
---
G
L
N
V
E
K
K
V
K
F
V
A
G
H
S
L
G
E
Y
S
A
L
C
A
A
G
T
F
S
L
T
D
T
A
R
L
L
R
I
R
G
N
A
M
Q
A
A
V
A
V
G
E
G
S
M
A
A
L
I
G
L
D
E
K
D
V
E
-
E
I
C
E
I
V
-
A
E
E
G
L
C
Q
I
A
N
D
N
G
G
G
Q
I
---------
V
I
S
G
E
A
K
A
V
E
T
A
V
E
V
A
S
Q
K
G
---
A
K
R
A
V
L
L
P
V
S
A
P
F
H
S
A
L
M
Q
P
A
A
N
A
M
K
N
A
L
L
T
V
N
K
T
A
P
I
V
P
L
I
A
N
V
S
V
I
P
E
S
D
P
E
R
I
V
S
L
L
V
Q
Q
V
T
G
R
V
R
W
R
E
T
I
E
W
I
-----
S
A
N
G
V
N
T
L
F
E
I
G
S
G
K
V
L
T
G
L
A
R
R
I
N
K
D
I
K
A
L
T
V
G
T
A
E
E
I
E
A
A
L
R
V
L
G
V
-----------
1
PsiBlast_PDB
93.15
44%
-101
- C1 -
3QAT
2
?
A:
[9-311]
--
F
T
F
P
G
Q
G
S
Q
L
I
G
M
G
K
V
L
T
E
Q
F
V
A
A
R
M
V
F
E
E
V
D
D
A
L
S
E
K
L
S
D
I
I
F
E
G
P
A
D
V
L
T
L
T
A
N
A
Q
P
A
L
M
A
V
-
S
M
A
V
I
R
V
M
E
Q
L
---
G
L
N
V
E
K
K
V
K
F
V
A
G
H
S
L
G
E
Y
S
A
L
C
A
A
G
T
F
S
L
T
D
T
A
R
L
L
R
I
R
G
N
A
M
Q
A
A
V
A
V
G
E
G
S
M
A
A
L
I
G
L
D
E
K
D
V
E
-
E
I
C
E
I
V
-
A
E
E
G
L
C
Q
I
A
N
D
N
G
G
G
Q
I
---------
V
I
S
G
E
A
K
A
V
E
T
A
V
E
V
A
S
Q
K
G
---
A
K
R
A
V
L
L
P
V
S
A
P
F
H
S
A
L
M
Q
P
A
A
N
A
M
K
N
A
L
L
T
V
N
K
T
A
P
I
V
P
L
I
A
N
V
S
V
I
P
E
S
D
P
E
R
I
V
S
L
L
V
Q
Q
V
T
G
R
V
R
W
R
E
T
I
E
W
I
-----
S
A
N
G
V
N
T
L
F
E
I
G
S
G
K
V
L
T
G
L
A
R
R
I
N
K
D
I
K
A
L
T
V
G
T
A
E
E
I
E
A
A
L
R
V
L
G
V
-----------
33
HHSearch
90.43
36%
-107
- C1 -
3EZO
-
?
A:
[2-305]
F
A
F
V
F
P
G
Q
G
S
Q
S
V
G
M
L
N
A
F
A
D
-
V
A
V
V
R
E
T
L
D
E
A
S
D
A
L
G
Q
D
I
G
K
L
I
A
D
G
P
A
D
E
L
N
L
T
T
N
T
Q
P
V
M
L
T
A
-
A
Y
A
C
Y
R
A
W
Q
Q
A
G
G
------
A
Q
P
S
I
V
A
G
H
S
L
G
E
Y
T
A
L
V
A
A
G
A
I
A
F
R
D
A
L
P
L
V
R
F
R
A
Q
A
M
Q
T
A
V
P
V
G
V
G
G
M
A
A
I
L
G
L
D
D
D
T
V
R
-
A
V
C
A
E
A
-
S
A
T
G
V
V
E
A
V
N
F
N
A
P
A
Q
V
---------
V
I
A
G
T
K
A
G
I
E
K
A
C
E
I
A
K
E
K
G
---
A
K
R
A
L
P
L
P
V
S
A
P
F
H
S
S
L
L
K
P
A
S
D
K
L
R
E
Y
L
A
G
V
D
V
K
A
P
K
I
S
V
V
N
N
I
D
V
A
V
V
S
D
P
A
A
I
K
D
A
L
V
R
Q
A
A
G
P
V
R
W
V
E
C
V
Q
H
I
-----
A
R
E
G
V
T
H
V
I
E
C
G
P
G
K
V
L
A
G
L
T
K
R
I
D
G
N
L
V
G
A
S
V
F
D
P
A
S
L
D
E
A
L
K
L
--------------
30
HHSearch
90.15
35%
-106
- C1 -
1MLA
-
FABD_ECOLI
A:
[4-297]
F
A
F
V
F
P
G
Q
G
S
Q
T
V
G
M
L
A
D
M
A
A
S
Y
P
I
V
E
E
T
F
A
E
A
S
A
A
L
G
Y
D
L
W
A
L
T
Q
Q
G
P
A
E
E
L
N
K
T
W
Q
T
Q
P
A
L
L
T
A
-
S
V
A
L
Y
R
V
W
Q
Q
Q
G
G
------
K
A
P
A
M
M
A
G
H
S
L
G
E
Y
S
A
L
V
C
A
G
V
I
D
F
A
D
A
V
R
L
V
E
M
R
G
K
F
M
Q
E
A
V
P
E
G
T
G
A
M
A
A
I
I
G
L
D
D
A
S
I
A
-
K
A
C
E
E
A
-
A
E
G
Q
V
V
S
P
V
N
F
N
S
P
G
Q
V
---------
V
I
A
G
H
K
E
A
V
E
R
A
G
A
A
C
K
A
A
G
---
A
K
R
A
L
P
L
P
V
S
V
P
S
H
C
A
L
M
K
P
A
A
D
K
L
A
V
E
L
A
K
I
T
F
N
A
P
T
V
P
V
V
N
N
V
D
V
K
C
E
T
N
G
D
A
I
R
D
A
L
V
R
Q
L
Y
N
P
V
Q
W
T
K
S
V
E
Y
M
-----
A
A
Q
G
V
E
H
L
Y
E
V
G
P
G
K
V
L
T
G
L
T
K
R
I
V
D
T
L
T
A
S
A
L
N
E
P
S
A
M
A
A
A
L
----------------
40
HHSearch
88.65
37%
-100
- C1 -
3K89
1
?
A:
[6-305]
L
A
F
V
F
P
G
Q
G
S
Q
S
L
G
M
L
A
E
L
S
E
L
H
P
Q
I
R
E
T
F
A
E
A
S
E
G
A
G
V
D
L
W
A
L
S
Q
G
G
P
E
E
M
L
N
R
T
E
Y
T
Q
P
A
L
L
A
A
-
G
V
A
V
W
R
L
W
T
A
Q
R
G
------
Q
R
P
A
L
L
A
G
H
S
L
G
E
Y
T
A
L
V
A
A
G
V
L
S
L
H
D
G
A
H
L
V
R
L
R
G
Q
F
M
Q
A
A
A
P
A
G
V
G
A
M
A
A
V
L
G
A
E
D
A
V
V
L
-
E
V
C
A
E
A
-
A
G
S
Q
V
V
V
P
A
N
F
N
S
P
G
Q
I
---------
V
I
G
G
D
A
A
A
V
D
R
A
L
A
L
L
A
E
R
G
---
V
R
K
A
V
K
L
A
V
S
V
P
S
H
T
P
L
M
R
D
A
A
N
Q
L
G
E
A
M
A
G
L
S
W
H
A
P
Q
I
P
V
V
Q
N
V
D
A
R
V
H
D
G
S
A
A
I
R
Q
A
L
V
E
Q
L
Y
L
P
V
Q
W
T
G
C
V
Q
A
L
-----
A
S
Q
G
I
T
R
I
A
E
C
G
P
G
K
V
L
S
G
L
I
K
R
I
D
K
S
L
D
A
R
P
L
A
T
P
A
D
Y
A
G
A
L
D
A
W
A
H
-----------
8
PsiBlast_PDB
88.51
34%
-99
- C1 -
2G2Y
1
FABD_ECOLI
A:
[5-300]
--
F
V
F
P
G
Q
G
S
Q
T
V
G
M
L
A
D
M
A
A
S
Y
P
I
V
E
E
T
F
A
E
A
S
A
A
L
G
Y
D
L
W
A
L
T
Q
Q
G
P
A
E
E
L
N
K
T
W
Q
T
Q
P
A
L
L
T
A
-
S
V
A
L
Y
R
V
W
Q
Q
Q
G
G
K
A
------
P
A
M
M
A
G
H
S
L
G
E
Y
S
A
L
V
C
A
G
V
I
D
F
A
D
A
V
R
L
V
E
M
R
G
K
F
M
Q
E
A
V
P
E
G
T
G
A
M
A
A
I
I
G
L
D
D
A
S
I
A
-
K
A
C
E
E
A
-
A
E
G
Q
V
V
S
P
V
N
F
N
S
P
G
Q
V
---------
V
I
A
G
H
K
E
A
V
E
R
A
G
A
A
C
K
A
A
G
---
A
K
R
A
L
P
L
P
V
S
V
P
S
H
C
A
L
M
K
P
A
A
D
K
L
A
V
E
L
A
K
I
T
F
N
A
P
T
V
P
V
V
N
N
V
D
V
K
C
E
T
N
G
D
A
I
R
D
A
L
V
R
Q
L
Y
N
P
V
Q
W
T
K
S
V
E
Y
M
-----
A
A
Q
G
V
E
H
L
Y
E
V
G
P
G
K
V
L
T
G
L
T
K
R
I
V
D
T
L
T
A
S
A
L
N
E
P
S
A
M
A
A
A
L
----------------
12
PsiBlast_PDB
87.49
36%
-97
- C1 -
3R97
1
?
A:
[6-304]
L
A
F
V
F
P
G
Q
G
S
Q
S
L
G
M
L
A
E
L
S
E
L
H
P
Q
I
R
E
T
F
A
E
A
S
E
G
A
G
V
D
L
W
A
L
S
Q
G
G
P
E
E
M
L
N
R
T
E
Y
T
Q
P
A
L
L
A
A
-
G
V
A
V
W
R
L
W
T
A
Q
R
G
Q
R
------
P
A
L
L
A
G
H
S
L
G
E
Y
T
A
L
V
A
A
G
V
L
S
L
H
D
G
A
H
L
V
R
L
R
G
Q
F
M
Q
A
A
A
P
A
G
V
G
A
M
A
A
V
L
G
A
E
D
A
V
V
L
-
E
V
C
A
E
A
-
A
G
S
Q
V
V
V
P
A
N
F
N
S
P
G
Q
I
---------
V
I
G
G
D
A
A
A
V
D
R
A
L
A
L
L
A
E
R
G
---
V
R
K
A
V
K
L
A
V
S
V
P
S
H
T
P
L
M
R
D
A
A
N
Q
L
G
E
A
M
A
G
L
S
W
H
A
P
Q
I
P
V
V
Q
N
V
D
A
R
V
H
D
G
S
A
A
I
R
Q
A
L
V
E
Q
L
Y
L
P
V
Q
W
T
G
C
V
Q
A
L
-----
A
S
Q
G
I
T
R
I
A
E
C
G
P
G
K
V
L
S
G
L
I
K
R
I
D
K
S
L
D
A
R
P
L
A
T
P
A
D
Y
A
G
A
L
D
A
W
A
H
-----------
10
PsiBlast_PDB
87.45
34%
-100
- C1 -
1MLA
-
FABD_ECOLI
A:
[6-301]
--
F
V
F
P
G
Q
G
S
Q
T
V
G
M
L
A
D
M
A
A
S
Y
P
I
V
E
E
T
F
A
E
A
S
A
A
L
G
Y
D
L
W
A
L
T
Q
Q
G
P
A
E
E
L
N
K
T
W
Q
T
Q
P
A
L
L
T
A
-
S
V
A
L
Y
R
V
W
Q
Q
Q
G
G
K
A
------
P
A
M
M
A
G
H
S
L
G
E
Y
S
A
L
V
C
A
G
V
I
D
F
A
D
A
V
R
L
V
E
M
R
G
K
F
M
Q
E
A
V
P
E
G
T
G
A
M
A
A
I
I
G
L
D
D
A
S
I
A
-
K
A
C
E
E
A
-
A
E
G
Q
V
V
S
P
V
N
F
N
S
P
G
Q
V
---------
V
I
A
G
H
K
E
A
V
E
R
A
G
A
A
C
K
A
A
G
---
A
K
R
A
L
P
L
P
V
S
V
P
S
H
C
A
L
M
K
P
A
A
D
K
L
A
V
E
L
A
K
I
T
F
N
A
P
T
V
P
V
V
N
N
V
D
V
K
C
E
T
N
G
D
A
I
R
D
A
L
V
R
Q
L
Y
N
P
V
Q
W
T
K
S
V
E
Y
M
-----
A
A
Q
G
V
E
H
L
Y
E
V
G
P
G
K
V
L
T
G
L
T
K
R
I
V
D
T
L
T
A
S
A
L
N
E
P
S
A
M
A
A
A
L
----------------
6
PsiBlast_PDB
87.43
34%
-100
- C1 -
2G1H
1
FABD_ECOLI
A:
[5-300]
--
F
V
F
P
G
Q
G
S
Q
T
V
G
M
L
A
D
M
A
A
S
Y
P
I
V
E
E
T
F
A
E
A
S
A
A
L
G
Y
D
L
W
A
L
T
Q
Q
G
P
A
E
E
L
N
K
T
W
Q
T
Q
P
A
L
L
T
A
-
S
V
A
L
Y
R
V
W
Q
Q
Q
G
G
K
A
------
P
A
M
M
A
G
H
S
L
G
E
Y
S
A
L
V
C
A
G
V
I
D
F
A
D
A
V
R
L
V
E
M
R
G
K
F
M
Q
E
A
V
P
E
G
T
G
A
M
A
A
I
I
G
L
D
D
A
S
I
A
-
K
A
C
E
E
A
-
A
E
G
Q
V
V
S
P
V
N
F
N
S
P
G
Q
V
---------
V
I
A
G
H
K
E
A
V
E
R
A
G
A
A
C
K
A
A
G
---
A
K
R
A
L
P
L
P
V
S
V
P
S
H
C
A
L
M
K
P
A
A
D
K
L
A
V
E
L
A
K
I
T
F
N
A
P
T
V
P
V
V
N
N
V
D
V
K
C
E
T
N
G
D
A
I
R
D
A
L
V
R
Q
L
Y
N
P
V
Q
W
T
K
S
V
E
Y
M
-----
A
A
Q
G
V
E
H
L
Y
E
V
G
P
G
K
V
L
T
G
L
T
K
R
I
V
D
T
L
T
A
S
A
L
N
E
P
S
A
M
A
A
A
L
E
L
--------------
5
PsiBlast_PDB
86.89
34%
-103
- C1 -
3HJV
18
?
A:
[13-310]
----
F
P
G
Q
G
S
Q
A
V
G
M
L
A
D
L
A
E
Q
Y
A
V
V
K
Q
T
F
A
E
A
S
E
V
L
G
Y
D
L
W
A
L
V
Q
D
G
P
V
E
D
L
N
Q
T
F
R
T
Q
P
A
L
L
A
A
-
S
V
A
I
W
R
V
W
Q
Q
------
L
G
L
E
Q
P
A
V
L
A
G
H
S
L
G
E
Y
S
A
L
V
C
A
G
V
I
D
F
K
Q
A
I
K
L
V
E
L
R
G
Q
L
M
Q
Q
A
V
P
A
G
T
G
A
M
Y
A
I
I
G
L
E
D
E
A
I
A
-
K
A
C
A
D
A
-
A
Q
G
E
V
V
S
P
V
N
F
N
S
P
G
Q
V
---------
V
I
A
G
Q
K
D
A
V
E
R
A
G
V
L
C
K
E
A
G
---
A
K
R
A
L
P
L
P
V
S
V
P
S
H
C
A
L
M
K
P
A
A
D
E
L
A
K
T
L
A
E
L
E
F
N
A
P
Q
I
P
V
I
N
N
V
D
V
V
A
E
T
D
P
V
K
I
K
D
A
L
I
R
Q
L
Y
S
P
V
R
W
T
E
C
V
E
Q
M
-----
S
A
Q
G
V
E
K
L
I
E
M
G
P
G
K
V
L
T
G
L
T
K
R
I
V
K
T
L
E
G
V
A
V
N
D
V
A
S
L
D
A
V
K
----------------
2
PsiBlast_PDB
86.89
35%
-101
- C1 -
3EZO
-
?
A:
[4-301]
--
F
V
F
P
G
Q
G
S
Q
S
V
G
M
-
L
N
A
F
A
D
V
A
V
V
R
E
T
L
D
E
A
S
D
A
L
G
Q
D
I
G
K
L
I
A
D
G
P
A
D
E
L
N
L
T
T
N
T
Q
P
V
M
L
T
A
-
A
Y
A
C
Y
R
A
W
Q
Q
A
G
G
A
Q
------
P
S
I
V
A
G
H
S
L
G
E
Y
T
A
L
V
A
A
G
A
I
A
F
R
D
A
L
P
L
V
R
F
R
A
Q
A
M
Q
T
A
V
P
V
G
V
G
G
M
A
A
I
L
G
L
D
D
D
T
V
R
-
A
V
C
A
E
A
-
S
A
T
G
V
V
E
A
V
N
F
N
A
P
A
Q
V
---------
V
I
A
G
T
K
A
G
I
E
K
A
C
E
I
A
K
E
K
G
---
A
K
R
A
L
P
L
P
V
S
A
P
F
H
S
S
L
L
K
P
A
S
D
K
L
R
E
Y
L
A
G
V
D
V
K
A
P
K
I
S
V
V
N
N
I
D
V
A
V
V
S
D
P
A
A
I
K
D
A
L
V
R
Q
A
A
G
P
V
R
W
V
E
C
V
Q
H
I
-----
A
R
E
G
V
T
H
V
I
E
C
G
P
G
K
V
L
A
G
L
T
K
R
I
D
G
N
L
V
G
A
S
V
F
D
P
A
S
L
D
E
A
L
K
L
--------------
11
PsiBlast_PDB
86.75
36%
-97
- C1 -
3K89
1
?
A:
[6-304]
L
A
F
V
F
P
G
Q
G
S
Q
S
L
G
M
L
A
E
L
S
E
L
H
P
Q
I
R
E
T
F
A
E
A
S
E
G
A
G
V
D
L
W
A
L
S
Q
G
G
P
E
E
M
L
N
R
T
E
Y
T
Q
P
A
L
L
A
A
-
G
V
A
V
W
R
L
W
T
A
Q
R
G
Q
R
------
P
A
L
L
A
G
H
S
L
G
E
Y
T
A
L
V
A
A
G
V
L
S
L
H
D
G
A
H
L
V
R
L
R
G
Q
F
M
Q
A
A
A
P
A
G
V
G
A
M
A
A
V
L
G
A
E
D
A
V
V
L
-
E
V
C
A
E
A
-
A
G
S
Q
V
V
V
P
A
N
F
N
S
P
G
Q
I
---------
V
I
G
G
D
A
A
A
V
D
R
A
L
A
L
L
A
E
R
G
---
V
R
K
A
V
K
L
A
V
S
V
P
S
H
T
P
L
M
R
D
A
A
N
Q
L
G
E
A
M
A
G
L
S
W
H
A
P
Q
I
P
V
V
Q
N
V
D
A
R
V
H
D
G
S
A
A
I
R
Q
A
L
V
E
Q
L
Y
L
P
V
Q
W
T
G
C
V
Q
A
L
-----
A
S
Q
G
I
T
R
I
A
E
C
G
P
G
K
V
L
S
G
L
I
K
R
I
D
K
S
L
D
A
R
P
L
A
T
P
A
D
Y
A
G
A
L
D
A
W
A
H
-----------
7
PsiBlast_PDB
86.66
34%
-98
- C1 -
2G2O
1
FABD_ECOLI
A:
[5-300]
--
F
V
F
P
G
Q
G
S
Q
T
V
G
M
L
A
D
M
A
A
S
Y
P
I
V
E
E
T
F
A
E
A
S
A
A
L
G
Y
D
L
W
A
L
T
Q
Q
G
P
A
E
E
L
N
K
T
W
Q
T
Q
P
A
L
L
T
A
-
S
V
A
L
Y
R
V
W
Q
Q
Q
G
G
K
A
------
P
A
M
M
A
G
H
S
L
G
E
Y
S
A
L
V
C
A
G
V
I
D
F
A
D
A
V
R
L
V
E
M
R
G
K
F
M
Q
E
A
V
P
E
G
T
G
A
M
A
A
I
I
G
L
D
D
A
S
I
A
-
K
A
C
E
E
A
-
A
E
G
Q
V
V
S
P
V
N
F
N
S
P
G
Q
V
---------
V
I
A
G
H
K
E
A
V
E
R
A
G
A
A
C
K
A
A
G
---
A
K
R
A
L
P
L
P
V
S
V
P
S
H
C
A
L
M
K
P
A
A
D
K
L
A
V
E
L
A
K
I
T
F
N
A
P
T
V
P
V
V
N
N
V
D
V
K
C
E
T
N
G
D
A
I
R
D
A
L
V
R
Q
L
Y
N
P
V
Q
W
T
K
S
V
E
Y
M
-----
A
A
Q
G
V
E
H
L
Y
E
V
G
P
G
K
V
L
T
G
L
T
K
R
I
V
D
T
L
T
A
S
A
L
N
E
P
S
A
M
A
A
A
L
E
L
--------------
29
HHSearch
86.16
33%
-100
- C1 -
3TQE
3
?
A:
[8-316]
F
A
F
V
F
P
G
Q
G
S
Q
H
L
G
M
L
A
E
L
G
L
Q
Q
P
I
V
L
E
T
F
Q
Q
A
S
S
A
L
A
Y
D
L
W
A
L
V
Q
H
G
P
Q
E
R
L
D
Q
T
Q
F
T
Q
P
A
L
L
T
A
-
D
V
A
I
F
R
C
W
E
A
L
G
G
------
P
K
P
Q
V
M
A
G
H
S
L
G
E
Y
A
A
L
V
C
A
G
A
L
K
F
E
E
A
V
K
L
V
E
K
R
G
Q
Y
M
Q
E
A
V
P
V
G
E
G
A
M
G
A
I
I
G
L
N
E
A
E
I
E
-
S
I
C
E
N
A
-
A
L
G
Q
V
V
Q
P
A
N
L
N
S
T
D
Q
T
---------
V
I
S
G
H
S
E
A
V
D
R
A
L
N
M
A
K
T
E
G
---
A
K
I
A
K
R
I
P
V
S
V
P
S
H
C
P
L
M
Q
P
A
A
D
R
L
A
Q
D
I
A
K
I
S
I
D
S
P
K
V
P
V
I
H
N
V
D
V
V
D
H
N
E
A
N
I
I
R
G
A
L
I
K
Q
L
V
R
P
V
R
W
V
E
T
I
K
Y
I
-----
E
E
Q
G
I
K
V
F
M
E
C
G
P
D
N
K
L
A
G
L
I
K
R
I
D
R
Q
S
E
I
L
P
L
---
T
T
T
E
L
I
L
T
A
I
K
R
L
T
H
--------
9
PsiBlast_PDB
86.05
34%
-99
- C1 -
2G2Z
2
FABD_ECOLI
A:
[5-300]
--
F
V
F
P
G
Q
G
S
Q
T
V
G
M
L
A
D
M
A
A
S
Y
P
I
V
E
E
T
F
A
E
A
S
A
A
L
G
Y
D
L
W
A
L
T
Q
Q
G
P
A
E
E
L
N
K
T
W
Q
T
Q
P
A
L
L
T
A
-
S
V
A
L
Y
R
V
W
Q
Q
Q
G
G
K
A
------
P
A
M
M
A
G
H
S
L
G
E
Y
S
A
L
V
C
A
G
V
I
D
F
A
D
A
V
R
L
V
E
M
R
G
K
F
M
Q
E
A
V
P
E
G
T
G
A
M
A
A
I
I
G
L
D
D
A
S
I
A
-
K
A
C
E
E
A
-
A
E
G
Q
V
V
S
P
V
N
F
N
S
P
G
Q
V
---------
V
I
A
G
H
K
E
A
V
E
R
A
G
A
A
C
K
A
A
G
---
A
K
R
A
L
P
L
P
V
S
V
P
S
H
C
A
L
M
K
P
A
A
D
K
L
A
V
E
L
A
K
I
T
F
N
A
P
T
V
P
V
V
N
N
V
D
V
K
C
E
T
N
G
D
A
I
R
D
A
L
V
R
Q
L
Y
N
P
V
Q
W
T
K
S
V
E
Y
M
-----
A
A
Q
G
V
E
H
L
Y
E
V
G
P
G
K
V
L
T
G
L
T
K
R
I
V
D
T
L
T
A
S
A
L
N
E
P
S
A
M
A
A
A
L
E
L
--------------
19
PsiBlast_PDB
85.05
35%
-110
- C1 -
3SBM
4
?
A:
[4-277]
--
Y
M
F
P
G
Q
G
S
Q
A
K
G
M
G
R
A
L
F
D
A
F
P
A
---
L
T
A
R
A
D
G
V
L
G
Y
S
I
R
A
L
C
Q
D
D
P
D
Q
R
L
S
Q
T
Q
F
T
Q
P
A
L
Y
V
V
N
A
L
S
Y
L
K
R
R
E
E
--------
E
A
P
P
D
F
L
A
G
H
S
L
G
E
F
S
A
L
F
A
A
G
V
F
D
F
E
T
G
L
A
L
V
K
K
R
G
E
L
M
G
D
A
R
---
G
G
G
M
A
A
V
I
G
L
D
E
E
R
V
R
-
E
L
L
D
Q
N
-
G
A
T
A
V
-
D
I
A
N
L
N
S
P
S
Q
V
---------
V
I
S
G
A
K
D
E
I
A
R
L
Q
V
P
F
E
A
A
G
---
A
K
K
Y
T
V
L
R
V
S
A
A
F
H
S
R
F
M
R
P
A
M
V
E
F
G
R
F
L
E
G
Y
D
F
A
P
P
K
I
P
V
I
S
N
V
T
A
R
-
P
C
K
A
D
G
I
R
A
A
L
S
E
Q
I
A
S
P
V
R
W
C
E
S
I
R
Y
L
-----
M
G
R
G
V
E
E
F
V
E
C
G
H
G
I
V
L
T
G
L
Y
A
Q
I
R
R
D
A
-------------------------------
18
PsiBlast_PDB
84.94
35%
-109
- C1 -
3RGI
-
?
A:
[4-277]
--
Y
M
F
P
G
Q
G
S
Q
A
K
G
M
G
R
A
L
F
D
A
F
P
A
---
L
T
A
R
A
D
G
V
L
G
Y
S
I
R
A
L
C
Q
D
D
P
D
Q
R
L
S
Q
T
Q
F
T
Q
P
A
L
Y
V
V
N
A
L
S
Y
L
K
R
R
E
E
--------
E
A
P
P
D
F
L
A
G
H
S
L
G
E
F
S
A
L
F
A
A
G
V
F
D
F
E
T
G
L
A
L
V
K
K
R
G
E
L
M
G
D
A
R
---
G
G
G
M
A
A
V
I
G
L
D
E
E
R
V
R
-
E
L
L
D
Q
N
-
G
A
T
A
V
-
D
I
A
N
L
N
S
P
S
Q
V
---------
V
I
S
G
A
K
D
E
I
A
R
L
Q
V
P
F
E
A
A
G
---
A
K
K
Y
T
V
L
R
V
S
A
A
F
H
S
R
F
M
R
P
A
M
V
E
F
G
R
F
L
E
G
Y
D
F
A
P
P
K
I
P
V
I
S
N
V
T
A
R
-
P
C
K
A
D
G
I
R
A
A
L
S
E
Q
I
A
S
P
V
R
W
C
E
S
I
R
Y
L
-----
M
G
R
G
V
E
E
F
V
E
C
G
H
G
I
V
L
T
G
L
Y
A
Q
I
R
R
D
A
Q
------------------------------
36
HHSearch
84.71
34%
-102
- C1 -
3IM9
3
FABD_STAAM
A:
[12-312]
M
A
I
I
F
P
G
Q
G
A
Q
K
V
G
M
A
Q
D
L
F
N
N
N
D
Q
A
T
E
I
L
T
S
A
A
K
T
L
D
F
D
I
L
E
T
M
F
T
D
E
E
G
K
L
G
E
T
E
N
T
Q
P
A
L
L
T
H
-
S
S
A
L
L
A
A
L
K
N
---------
L
N
P
D
F
T
M
G
H
S
L
G
E
Y
S
S
L
V
A
A
D
V
L
S
F
E
D
A
V
K
I
V
R
K
R
G
Q
L
M
A
Q
A
F
P
T
G
V
G
S
M
A
A
V
L
G
L
D
F
D
K
V
D
-
E
I
C
K
S
L
S
S
D
D
K
I
I
E
P
A
N
I
N
C
P
G
Q
I
---------
V
V
S
G
H
K
A
L
I
D
E
L
V
E
K
G
K
S
L
G
---
A
K
R
V
M
P
L
A
V
S
G
P
F
H
S
S
L
M
K
V
I
E
E
D
F
S
S
Y
I
N
Q
F
E
W
R
D
A
K
F
P
V
V
Q
N
V
N
A
Q
G
E
T
D
K
E
V
I
K
S
N
M
V
K
Q
L
Y
S
P
V
Q
F
I
N
S
T
E
W
L
-----
I
D
Q
G
V
D
H
F
I
E
I
G
P
G
K
V
L
S
G
L
I
K
K
I
N
R
D
V
K
L
T
S
I
Q
T
L
E
D
V
K
G
W
N
----------------
16
PsiBlast_PDB
84.71
32%
-100
- C1 -
3H0P
1
FABD_SALTY
A:
[9-296]
--
F
V
F
P
G
Q
G
S
Q
S
V
G
M
L
A
E
M
A
A
N
Y
P
I
V
E
E
T
F
A
E
A
S
A
A
L
G
Y
D
L
W
A
L
T
Q
Q
G
P
A
E
E
L
N
K
T
W
Q
T
Q
P
A
L
L
T
A
-
S
V
A
L
W
R
V
W
Q
Q
Q
G
G
K
M
------
P
A
L
M
A
G
H
S
L
G
E
Y
S
A
L
V
C
A
G
V
I
N
F
A
D
A
V
R
L
V
E
M
R
G
K
F
M
Q
E
A
V
P
E
G
T
G
G
M
S
A
I
I
G
L
D
D
A
S
I
A
-
K
A
C
E
E
S
-
A
E
G
Q
V
V
S
P
V
N
F
N
S
P
G
Q
V
---------
V
I
A
G
H
K
E
A
V
E
R
A
G
A
A
C
K
A
A
G
---
A
K
R
A
L
P
L
P
V
S
V
P
S
H
C
A
L
M
K
P
A
A
D
K
L
A
V
E
L
A
K
I
T
F
S
A
P
T
V
P
V
V
N
N
V
D
V
K
C
E
T
D
A
A
A
I
R
D
A
L
V
R
Q
L
Y
N
P
V
Q
W
T
K
S
V
E
F
I
-----
A
A
Q
G
V
E
H
L
Y
E
V
G
P
G
K
V
L
T
G
L
T
K
R
I
V
D
T
L
T
A
S
A
L
N
E
P
A
A
L
S
A
A
L
T
Q
--------------
23
PsiBlast_CBE
82.71
33%
-96
- C1 -
2C2N
8
FABD_HUMAN
A:
[28-337]
-
V
L
L
F
P
G
Q
G
S
Q
V
V
G
M
G
R
G
L
L
N
-
Y
P
R
V
R
E
L
Y
A
A
A
R
R
V
L
G
Y
D
L
L
E
L
S
L
H
G
P
Q
E
T
L
D
R
T
V
H
C
Q
P
A
I
F
V
A
-
S
L
A
A
V
E
K
L
H
H
L
Q
P
S
V
I
---
E
N
C
V
A
A
A
G
F
S
V
G
E
F
A
A
L
V
F
A
G
A
M
E
F
A
E
G
L
Y
A
V
K
I
R
A
E
A
M
Q
E
A
S
E
A
V
P
S
G
M
L
S
V
L
G
Q
P
Q
S
K
F
N
F
A
C
L
E
A
R
-
E
H
C
K
S
L
G
I
--
E
N
P
V
C
E
V
SNYLFPD
C
R
V
I
S
G
H
Q
E
A
L
R
F
L
Q
---
K
N
S
S
KFH
F
R
R
T
R
M
L
P
V
S
G
A
F
H
T
R
L
M
E
P
A
V
E
P
L
T
Q
A
L
K
A
V
D
I
K
K
P
L
V
S
V
Y
S
N
V
H
G
H
R
Y
R
H
P
G
H
I
H
K
L
L
A
Q
Q
L
V
S
P
V
K
W
-
E
Q
T
M
H
A
I
Y
ERK
K
G
R
G
F
P
Q
T
F
E
V
G
P
G
R
Q
L
G
A
I
L
K
----
S
C
N
M
Q
A
W
K
S
Y
S
A
V
D
V
L
-----------------