@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0434: (2015-12-01 )
MNIALKYRPGSFKDLVGQDILVRILENAFTLNRIPQSILLSGASGVGKTTTARIIALCLNCSLGPTFEPCGSCKNCLTIKNSSHPDVIEIDAASHTSVDDIKVILGDICYSPISSKFKVYIIDEVHMLSSSAFNALLKTLEEPPPSVKFILATTEIKKIPITIIARCQRFDLYNIPVAKIVERLNDIAQRESYFIEKEASELIARHSGNSMRNALFLMNQAVLYNKGGVISTKSVMDILGLVDKDIIFDLMEAILGSDLQKALSLFDKAVETANPLSIFEGLLQTIQLICRFLVTKEIDSSVTECEKNRIKDLGVKKSLIFFSRLWRMLLKGVQDIKASTCSDVAAEMILISLCYLSDLPSPEQVVKKVLAQSTQQRNTRSAENIQQKSYDFDKILQLLQQNNQIYLYKQLCSNLQLVNCKPGYLKLKAVSQLDSNFCNDLKNYLSQITQQEWVITIDAGYIKKGASSLSYAPAVKGILDTFKGAKVVNIENKE
Atome Classification :
(33 SA)
-.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......----270.-.......280.......290.......300.......310.......320.......330.......340.......350...-.....360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-M
N
I
A
L
K
YRPG
S
F
K
D
L
V
G
Q
D
I
L
V
R
I
L
E
N
A
F
T
L
N
RI
P
Q
S
I
L
LSGASGVGK
T
T
T
A
R
I
I
A
L
C
LNCSLGPTFEPCGSCK
N
C
L
T
IKNSSHP
D
V
I
E
I
DAASHTS
V
D
D
I
K
V
I
L
G
D
ICYSPISS
K
F
K
V
Y
I
I
D
E
V
H
M
L
S
S
S
A
F
N
A
L
L
K
T
LEEPPPS
V
K
F
I
L
ATTEIKKI
P
I
T
I
I
A
R
CQRFDLYNI
P
V
A
K
I
V
E
R
L
N
D
I
A
Q
R
E
S
Y
F
I
E
K
E
A
S
E
L
I
A
R
HSG
N
S
M
R
N
A
L
F
L
M
N
Q
A
V
L
YNKGGVI
S
T
K
S
V
M
D
I
L
G
LV
D
K
D
I
I
F
D
L
M
E
A
I
L
G
S
D
L
Q
K
A
L
S
L
F
D
K
A
----VE-T-A
N
P
L
S
I
F
E
G
L
L
Q
T
I
Q
L
I
C
R
F
L
V
T
K
E
I
D
S
S
V
T
E
C
E
K
N
R
I
K
D
LGV
K
K
S
L
I
F
F
S
R
L
W
R
M
L
L
K
G
V
Q
D
I
KAS
T
C
S
D
V
A
A
E
M
I
L
I
-
S
L
C
-
Y
LSDLP
S
P
E
Q
V
V
K
K
V
L
A
Q
S
T
Q
QRNTR
S
A
E
N
I
Q
Q
KSY
D
F
D
K
I
L
Q
L
L
QQNN
Q
I
Y
L
Y
K
Q
L
CSN
L
Q
L
V
NCKPG
Y
L
K
L
K
A
V
S
Q
L
D
S
N
F
C
N
D
L
K
N
Y
L
S
Q
ITQQ
E
W
V
I
T
I
D
A
G
Y
I
KKGASSLSY
A
P
A
V
K
G
I
L
D
TFKG
A
K
V
V
N
IENKE
80
Fugue
94.84
36%
-119
- C1 -
1JR3
2
DPO3X_ECOLI
A:
[3-368]
Y
Q
V
L
A
R
K
W
R
P
Q
T
F
A
D
V
V
G
Q
E
H
V
L
T
A
L
A
N
G
L
S
L
G
R
I
H
H
A
Y
L
F
S
G
T
R
G
V
G
K
T
S
I
A
R
L
L
A
K
G
L
N
C
E
T
G
I
T
A
T
P
C
G
V
C
D
N
C
R
E
I
E
Q
G
R
F
V
D
L
I
E
I
D
A
A
S
R
T
K
V
E
D
T
R
D
L
L
D
N
V
Q
Y
A
P
A
R
G
R
F
K
V
Y
L
I
D
E
V
H
M
L
S
R
H
S
F
N
A
L
L
K
T
L
E
E
P
P
E
H
V
K
F
L
L
A
T
T
D
P
Q
K
L
P
V
T
I
L
S
R
C
L
Q
F
H
L
K
A
L
D
V
E
Q
I
R
H
Q
L
E
H
I
L
N
E
E
H
I
A
H
E
P
R
A
L
Q
L
L
A
R
A
A
E
G
S
L
R
D
A
L
S
L
T
D
Q
A
I
A
S
G
-
D
G
Q
V
S
T
Q
A
V
S
A
M
L
G
T
L
D
D
D
Q
A
L
S
L
V
E
A
M
V
E
A
N
G
E
R
V
M
A
L
I
N
E
A
----
A
A
-
R
G
I
E
W
E
A
L
L
V
E
M
L
G
L
L
H
R
I
A
M
V
Q
L
S
P
A
A
L
G
N
D
M
A
A
I
E
L
R
M
R
E
L
A
R
T
I
P
P
T
D
I
Q
L
Y
Y
Q
T
L
L
I
G
R
K
E
L
P
Y
A
P
D
R
R
M
G
V
E
M
T
L
L
-
R
A
L
A
F
H
P
R
M
P
L
P
E
P
----------------------------------------------------------------------------------------------------------------------------------
90
HHSearch
93.16
36%
-119
- C1 -
1JR3
2
DPO3X_ECOLI
A:
[5-363]
--
V
L
A
R
K
W
R
P
Q
T
F
A
D
V
V
G
Q
E
H
V
L
T
A
L
A
N
G
L
S
L
G
R
I
H
H
A
Y
L
F
S
G
T
R
G
V
G
K
T
S
I
A
R
L
L
A
K
G
L
N
C
E
T
G
I
T
A
T
P
C
G
V
C
D
N
C
R
E
I
E
Q
G
R
F
V
D
L
I
E
I
D
A
A
S
R
T
K
V
E
D
T
R
D
L
L
D
N
V
Q
Y
A
P
A
R
G
R
F
K
V
Y
L
I
D
E
V
H
M
L
S
R
H
S
F
N
A
L
L
K
T
L
E
E
P
P
E
H
V
K
F
L
L
A
T
T
D
P
Q
K
L
P
V
T
I
L
S
R
C
L
Q
F
H
L
K
A
L
D
V
E
Q
I
R
H
Q
L
E
H
I
L
N
E
E
H
I
A
H
E
P
R
A
L
Q
L
L
A
R
A
A
E
G
S
L
R
D
A
L
S
L
T
D
Q
A
I
A
S
G
D
G
-
Q
V
S
T
Q
A
V
S
A
M
L
G
T
L
D
D
D
Q
A
L
S
L
V
E
A
M
V
E
A
N
G
E
R
V
M
A
L
I
N
E
A
----
A
A
R
G
-
I
E
W
E
A
L
L
V
E
M
L
G
L
L
H
R
I
A
M
V
Q
L
S
P
A
A
L
G
N
D
M
A
A
I
E
L
R
M
R
E
L
A
R
T
I
P
P
T
D
I
Q
L
Y
Y
Q
T
L
L
I
G
R
K
E
L
P
Y
A
P
D
R
R
M
G
V
E
M
T
L
L
-
R
A
L
-
A
F
H
P
R
M
P
L
P
E
P
---------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
92.73
38%
-119
- C1 -
1XXH
2
DPO3X_ECOLI
I:
[6-368]
---
L
A
R
K
W
R
P
Q
T
F
A
D
V
V
G
Q
E
H
V
L
T
A
L
A
N
G
L
S
L
G
R
I
H
H
A
Y
L
F
S
G
T
R
G
V
G
K
T
S
I
A
R
L
L
A
K
G
L
N
C
E
T
G
I
T
A
T
P
C
G
V
C
D
N
C
R
E
I
E
Q
G
R
F
V
D
L
I
E
I
D
A
A
S
R
T
K
V
E
D
T
R
D
L
L
D
N
V
Q
Y
A
P
A
R
G
R
F
K
V
Y
L
I
D
E
V
H
M
L
S
R
H
S
F
N
A
L
L
K
T
L
E
E
P
P
E
H
V
K
F
L
L
A
T
T
D
P
Q
K
L
P
V
T
I
L
S
R
C
L
Q
F
H
L
K
A
L
D
V
E
Q
I
R
H
Q
L
E
H
I
L
N
E
E
H
I
A
H
E
P
R
A
L
Q
L
L
A
R
A
A
E
G
S
L
R
D
A
L
S
L
T
D
Q
A
I
A
S
G
D
G
Q
V
-
S
T
Q
A
V
S
A
M
L
G
T
L
D
D
D
Q
A
L
S
L
V
E
A
M
V
E
A
N
G
E
R
V
M
A
L
I
N
E
A
AARG
I
E
-
W
-
E
A
L
L
V
E
M
L
G
L
L
H
R
I
A
M
V
Q
L
S
P
A
A
L
G
N
D
M
A
A
I
E
L
---
R
M
R
E
L
A
R
T
I
P
P
T
D
I
Q
L
Y
Y
Q
T
L
L
I
G
R
K
E
L
P
Y
A
P
D
R
R
M
G
V
E
M
T
L
L
R
A
L
A
-
F
H
P
R
M
P
L
P
E
P
----------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
92.15
38%
-117
- C1 -
1XXI
2
DPO3X_ECOLI
I:
[6-367]
---
L
A
R
K
W
R
P
Q
T
F
A
D
V
V
G
Q
E
H
V
L
T
A
L
A
N
G
L
S
L
G
R
I
H
H
A
Y
L
F
S
G
T
R
G
V
G
K
T
S
I
A
R
L
L
A
K
G
L
N
C
E
T
G
I
T
A
T
P
C
G
V
C
D
N
C
R
E
I
E
Q
G
R
F
V
D
L
I
E
I
D
A
A
S
R
T
K
V
E
D
T
R
D
L
L
D
N
V
Q
Y
A
P
A
R
G
R
F
K
V
Y
L
I
D
E
V
H
M
L
S
R
H
S
F
N
A
L
L
K
T
L
E
E
P
P
E
H
V
K
F
L
L
A
T
T
D
P
Q
K
L
P
V
T
I
L
S
R
C
L
Q
F
H
L
K
A
L
D
V
E
Q
I
R
H
Q
L
E
H
I
L
N
E
E
H
I
A
H
E
P
R
A
L
Q
L
L
A
R
A
A
E
G
S
L
R
D
A
L
S
L
T
D
Q
A
I
A
S
G
D
G
Q
V
-
S
T
Q
A
V
S
A
M
L
G
T
L
D
D
D
Q
A
L
S
L
V
E
A
M
V
E
A
N
G
E
R
V
M
A
L
I
N
E
A
AARG
I
E
-
W
-
E
A
L
L
V
E
M
L
G
L
L
H
R
I
A
M
V
Q
L
S
P
A
A
L
G
N
D
M
A
A
I
E
L
---
R
M
R
E
L
A
R
T
I
P
P
T
D
I
Q
L
Y
Y
Q
T
L
L
I
G
R
K
E
L
P
Y
A
P
D
R
R
M
G
V
E
M
T
L
L
R
A
L
A
-
F
H
P
R
M
P
L
P
E
P
----------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
92.08
38%
-113
- C1 -
1JR3
2
DPO3X_ECOLI
A:
[6-368]
---
L
A
R
K
W
R
P
Q
T
F
A
D
V
V
G
Q
E
H
V
L
T
A
L
A
N
G
L
S
L
G
R
I
H
H
A
Y
L
F
S
G
T
R
G
V
G
K
T
S
I
A
R
L
L
A
K
G
L
N
C
E
T
G
I
T
A
T
P
C
G
V
C
D
N
C
R
E
I
E
Q
G
R
F
V
D
L
I
E
I
D
A
A
S
R
T
K
V
E
D
T
R
D
L
L
D
N
V
Q
Y
A
P
A
R
G
R
F
K
V
Y
L
I
D
E
V
H
M
L
S
R
H
S
F
N
A
L
L
K
T
L
E
E
P
P
E
H
V
K
F
L
L
A
T
T
D
P
Q
K
L
P
V
T
I
L
S
R
C
L
Q
F
H
L
K
A
L
D
V
E
Q
I
R
H
Q
L
E
H
I
L
N
E
E
H
I
A
H
E
P
R
A
L
Q
L
L
A
R
A
A
E
G
S
L
R
D
A
L
S
L
T
D
Q
A
I
A
S
G
D
G
Q
V
-
S
T
Q
A
V
S
A
M
L
G
T
L
D
D
D
Q
A
L
S
L
V
E
A
M
V
E
A
N
G
E
R
V
M
A
L
I
N
E
A
A
A
R
G
I
E
-
W
-
E
A
L
L
V
E
M
L
G
L
L
H
R
I
A
M
V
Q
L
S
P
A
A
L
G
N
D
M
A
A
I
E
L
---
R
M
R
E
L
A
R
T
I
P
P
T
D
I
Q
L
Y
Y
Q
T
L
L
I
G
R
K
E
L
P
Y
A
P
D
R
R
M
G
V
E
M
T
L
L
R
A
L
A
-
F
H
P
R
M
P
L
P
E
P
----------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
91.97
38%
-111
- C1 -
3GLF
6
DPO3X_ECOLI
C:
[28-390]
---
L
A
R
K
W
R
P
Q
T
F
A
D
V
V
G
Q
E
H
V
L
T
A
L
A
N
G
L
S
L
G
R
I
H
H
A
Y
L
F
S
G
T
R
G
V
G
K
T
S
I
A
R
L
L
A
K
G
L
N
C
E
T
G
I
T
A
T
P
C
G
V
C
D
N
C
R
E
I
E
Q
G
R
F
V
D
L
I
E
I
D
A
A
S
R
T
K
V
E
D
T
R
D
L
L
D
N
V
Q
Y
A
P
A
R
G
R
F
K
V
Y
L
I
D
E
V
H
M
L
S
R
H
S
F
N
A
L
L
K
T
L
E
E
P
P
E
H
V
K
F
L
L
A
T
T
D
P
Q
K
L
P
V
T
I
L
S
R
C
L
Q
F
H
L
K
A
L
D
V
E
Q
I
R
H
Q
L
E
H
I
L
N
E
E
H
I
A
H
E
P
R
A
L
Q
L
L
A
R
A
A
E
G
S
L
R
D
A
L
S
L
T
D
Q
A
I
A
S
G
D
G
Q
V
-
S
T
Q
A
V
S
A
M
L
G
T
L
D
D
D
Q
A
L
S
L
V
E
A
M
V
E
A
N
G
E
R
V
M
A
L
I
N
E
A
A
A
R
G
I
E
-
W
-
E
A
L
L
V
E
M
L
G
L
L
H
R
I
A
M
V
Q
L
S
P
A
A
L
G
N
D
M
A
A
I
E
L
---
R
M
R
E
L
A
R
T
I
P
P
T
D
I
Q
L
Y
Y
Q
T
L
L
I
G
R
K
E
L
P
Y
A
P
D
R
R
M
G
V
E
M
T
L
L
R
A
L
A
-
F
H
P
R
M
P
L
P
E
P
----------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
91.91
38%
-111
- C1 -
3GLF
6
DPO3X_ECOLI
H:
[28-390]
---
L
A
R
K
W
R
P
Q
T
F
A
D
V
V
G
Q
E
H
V
L
T
A
L
A
N
G
L
S
L
G
R
I
H
H
A
Y
L
F
S
G
T
R
G
V
G
K
T
S
I
A
R
L
L
A
K
G
L
N
C
E
T
G
I
T
A
T
P
C
G
V
C
D
N
C
R
E
I
E
Q
G
R
F
V
D
L
I
E
I
D
A
A
S
R
T
K
V
E
D
T
R
D
L
L
D
N
V
Q
Y
A
P
A
R
G
R
F
K
V
Y
L
I
D
E
V
H
M
L
S
R
H
S
F
N
A
L
L
K
T
L
E
E
P
P
E
H
V
K
F
L
L
A
T
T
D
P
Q
K
L
P
V
T
I
L
S
R
C
L
Q
F
H
L
K
A
L
D
V
E
Q
I
R
H
Q
L
E
H
I
L
N
E
E
H
I
A
H
E
P
R
A
L
Q
L
L
A
R
A
A
E
G
S
L
R
D
A
L
S
L
T
D
Q
A
I
A
S
G
D
G
Q
V
-
S
T
Q
A
V
S
A
M
L
G
T
L
D
D
D
Q
A
L
S
L
V
E
A
M
V
E
A
N
G
E
R
V
M
A
L
I
N
E
A
AARG
I
E
-
W
-
E
A
L
L
V
E
M
L
G
L
L
H
R
I
A
M
V
Q
L
S
P
A
A
L
G
N
D
M
A
A
I
E
L
---
R
M
R
E
L
A
R
T
I
P
P
T
D
I
Q
L
Y
Y
Q
T
L
L
I
G
R
K
E
L
P
Y
A
P
D
R
R
M
G
V
E
M
T
L
L
R
A
L
A
-
F
H
P
R
M
P
L
P
E
P
----------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
91.84
38%
-114
- C1 -
3GLG
6
DPO3X_ECOLI
I:
[28-385]
---
L
A
R
K
W
R
P
Q
T
F
A
D
V
V
G
Q
E
H
V
L
T
A
L
A
N
G
L
S
L
G
R
I
H
H
A
Y
L
F
S
G
T
R
G
V
G
K
T
S
I
A
R
L
L
A
K
G
L
N
C
E
T
G
I
T
A
T
P
C
G
V
C
D
N
C
R
E
I
E
Q
G
R
F
V
D
L
I
E
I
D
A
A
S
R
T
K
V
E
D
T
R
D
L
L
D
N
V
Q
Y
A
P
A
R
G
R
F
K
V
Y
L
I
D
E
V
H
M
L
S
R
H
S
F
N
A
L
L
K
T
L
E
E
P
P
E
H
V
K
F
L
L
A
T
A
D
P
Q
K
L
P
V
T
I
L
S
R
C
L
Q
F
H
L
K
A
L
D
V
E
Q
I
R
H
Q
L
E
H
I
L
N
E
E
H
I
A
H
E
P
R
A
L
Q
L
L
A
R
A
A
E
G
S
L
R
D
A
L
S
L
T
D
Q
A
I
A
S
G
D
G
Q
V
-
S
T
Q
A
V
S
A
M
L
G
T
L
D
D
D
Q
A
L
S
L
V
E
A
M
V
E
A
N
G
E
R
V
M
A
L
I
N
E
A
AARG
I
E
-
W
-
E
A
L
L
V
E
M
L
G
L
L
H
R
I
A
M
V
Q
L
S
P
A
A
L
G
N
D
M
A
A
I
E
L
---
R
M
R
E
L
A
R
T
I
P
P
T
D
I
Q
L
Y
Y
Q
T
L
L
I
G
R
K
E
L
P
Y
A
P
D
R
R
M
G
V
E
M
T
L
L
R
A
L
A
-
F
H
P
R
M
---------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
91.79
38%
-111
- C1 -
1XXI
1
DPO3X_ECOLI
H:
[6-367]
---
L
A
R
K
W
R
P
Q
T
F
A
D
V
V
G
Q
E
H
V
L
T
A
L
A
N
G
L
S
L
G
R
I
H
H
A
Y
L
F
S
G
T
R
G
V
G
K
T
S
I
A
R
L
L
A
K
G
L
N
C
E
T
G
I
T
A
T
P
C
G
V
C
D
N
C
R
E
I
E
Q
G
R
F
V
D
L
I
E
I
D
A
A
S
R
T
K
V
E
D
T
R
D
L
L
D
N
V
Q
Y
A
P
A
R
G
R
F
K
V
Y
L
I
D
E
V
H
M
L
S
R
H
S
F
N
A
L
L
K
T
L
E
E
P
P
E
H
V
K
F
L
L
A
T
T
D
P
Q
K
L
P
V
T
I
L
S
R
C
L
Q
F
H
L
K
A
L
D
V
E
Q
I
R
H
Q
L
E
H
I
L
N
E
E
H
I
A
H
E
P
R
A
L
Q
L
L
A
R
A
A
E
G
S
L
R
D
A
L
S
L
T
D
Q
A
I
A
S
G
D
G
Q
V
-
S
T
Q
A
V
S
A
M
L
G
T
L
D
D
D
Q
A
L
S
L
V
E
A
M
V
E
A
N
G
E
R
V
M
A
L
I
N
E
A
AARG
I
E
-
W
-
E
A
L
L
V
E
M
L
G
L
L
H
R
I
A
M
V
Q
L
S
P
A
A
L
G
N
D
M
A
A
I
E
L
---
R
M
R
E
L
A
R
T
I
P
P
T
D
I
Q
L
Y
Y
Q
T
L
L
I
G
R
K
E
L
P
Y
A
P
D
R
R
M
G
V
E
M
T
L
L
R
A
L
A
-
F
H
P
R
M
P
L
P
E
P
----------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
91.74
38%
-122
- C1 -
1XXI
2
DPO3X_ECOLI
B:
[6-367]
---
L
A
R
K
W
R
P
Q
T
F
A
D
V
V
G
Q
E
H
V
L
T
A
L
A
N
G
L
S
L
G
R
I
H
H
A
Y
L
F
S
G
T
R
G
V
G
K
T
S
I
A
R
L
L
A
K
G
L
N
C
E
T
G
I
T
A
T
P
C
G
V
C
D
N
C
R
E
I
E
Q
G
R
F
V
D
L
I
E
I
D
A
A
S
R
T
K
V
E
D
T
R
D
L
L
D
N
V
Q
Y
A
P
A
R
G
R
F
K
V
Y
L
I
D
E
V
H
M
L
S
R
H
S
F
N
A
L
L
K
T
L
E
E
P
P
E
H
V
K
F
L
L
A
T
T
D
P
Q
K
L
P
V
T
I
L
S
R
C
L
Q
F
H
L
K
A
L
D
V
E
Q
I
R
H
Q
L
E
H
I
L
N
E
E
H
I
A
H
E
P
R
A
L
Q
L
L
A
R
A
A
E
G
S
L
R
D
A
L
S
L
T
D
Q
A
I
A
S
G
D
G
Q
V
-
S
T
Q
A
V
S
A
M
L
G
T
L
D
D
D
Q
A
L
S
L
V
E
A
M
V
E
A
N
G
E
R
V
M
A
L
I
N
E
A
A
A
R
G
I
E
-
W
-
E
A
L
L
V
E
M
L
G
L
L
H
R
I
A
M
V
Q
L
S
P
A
A
L
G
N
D
M
A
A
I
E
L
---
R
M
R
E
L
A
R
T
I
P
P
T
D
I
Q
L
Y
Y
Q
T
L
L
I
G
R
K
E
L
P
Y
A
P
D
R
R
M
G
V
E
M
T
L
L
R
A
L
A
-
F
H
P
R
M
P
L
P
E
P
----------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
91.60
38%
-109
- C1 -
3GLI
6
DPO3X_ECOLI
H:
[28-390]
---
L
A
R
K
W
R
P
Q
T
F
A
D
V
V
G
Q
E
H
V
L
T
A
L
A
N
G
L
S
L
G
R
I
H
H
A
Y
L
F
S
G
T
R
G
V
G
K
T
S
I
A
R
L
L
A
K
G
L
N
C
E
T
G
I
T
A
T
P
C
G
V
C
D
N
C
R
E
I
E
Q
G
R
F
V
D
L
I
E
I
D
A
A
S
R
T
K
V
E
D
T
R
D
L
L
D
N
V
Q
Y
A
P
A
R
G
R
F
K
V
Y
L
I
D
E
V
H
M
L
S
R
H
S
F
N
A
L
L
K
T
L
E
E
P
P
E
H
V
K
F
L
L
A
T
T
D
P
Q
K
L
P
V
T
I
L
S
R
C
L
Q
F
H
L
K
A
L
D
V
E
Q
I
R
H
Q
L
E
H
I
L
N
E
E
H
I
A
H
E
P
R
A
L
Q
L
L
A
R
A
A
E
G
S
L
R
D
A
L
S
L
T
D
Q
A
I
A
S
G
D
G
Q
V
-
S
T
Q
A
V
S
A
M
L
G
T
L
D
D
D
Q
A
L
S
L
V
E
A
M
V
E
A
N
G
E
R
V
M
A
L
I
N
E
A
AARG
I
E
-
W
-
E
A
L
L
V
E
M
L
G
L
L
H
R
I
A
M
V
Q
L
S
P
A
A
L
G
N
D
M
A
A
I
E
L
---
R
M
R
E
L
A
R
T
I
P
P
T
D
I
Q
L
Y
Y
Q
T
L
L
I
G
R
K
E
L
P
Y
A
P
D
R
R
M
G
V
E
M
T
L
L
R
A
L
A
-
F
H
P
R
M
P
L
P
E
P
----------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
91.57
38%
-106
- C1 -
3GLG
6
DPO3X_ECOLI
C:
[28-390]
---
L
A
R
K
W
R
P
Q
T
F
A
D
V
V
G
Q
E
H
V
L
T
A
L
A
N
G
L
S
L
G
R
I
H
H
A
Y
L
F
S
G
T
R
G
V
G
K
T
S
I
A
R
L
L
A
K
G
L
N
C
E
T
G
I
T
A
T
P
C
G
V
C
D
N
C
R
E
I
E
Q
G
R
F
V
D
L
I
E
I
D
A
A
S
R
T
K
V
E
D
T
R
D
L
L
D
N
V
Q
Y
A
P
A
R
G
R
F
K
V
Y
L
I
D
E
V
H
M
L
S
R
H
S
F
N
A
L
L
K
T
L
E
E
P
P
E
H
V
K
F
L
L
A
T
A
D
P
Q
K
L
P
V
T
I
L
S
R
C
L
Q
F
H
L
K
A
L
D
V
E
Q
I
R
H
Q
L
E
H
I
L
N
E
E
H
I
A
H
E
P
R
A
L
Q
L
L
A
R
A
A
E
G
S
L
R
D
A
L
S
L
T
D
Q
A
I
A
S
G
D
G
Q
V
-
S
T
Q
A
V
S
A
M
L
G
T
L
D
D
D
Q
A
L
S
L
V
E
A
M
V
E
A
N
G
E
R
V
M
A
L
I
N
E
A
A
A
R
G
I
E
-
W
-
E
A
L
L
V
E
M
L
G
L
L
H
R
I
A
M
V
Q
L
S
P
A
A
L
G
N
D
M
A
A
I
E
L
---
R
M
R
E
L
A
R
T
I
P
P
T
D
I
Q
L
Y
Y
Q
T
L
L
I
G
R
K
E
L
P
Y
A
P
D
R
R
M
G
V
E
M
T
L
L
R
A
L
A
-
F
H
P
R
M
P
L
P
E
P
----------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
91.52
38%
-114
- C1 -
1XXH
2
DPO3X_ECOLI
H:
[6-368]
---
L
A
R
K
W
R
P
Q
T
F
A
D
V
V
G
Q
E
H
V
L
T
A
L
A
N
G
L
S
L
G
R
I
H
H
A
Y
L
F
S
G
T
R
G
V
G
K
T
S
I
A
R
L
L
A
K
G
L
N
C
E
T
G
I
T
A
T
P
C
G
V
C
D
N
C
R
E
I
E
Q
G
R
F
V
D
L
I
E
I
D
A
A
S
R
T
K
V
E
D
T
R
D
L
L
D
N
V
Q
Y
A
P
A
R
G
R
F
K
V
Y
L
I
D
E
V
H
M
L
S
R
H
S
F
N
A
L
L
K
T
L
E
E
P
P
E
H
V
K
F
L
L
A
T
T
D
P
Q
K
L
P
V
T
I
L
S
R
C
L
Q
F
H
L
K
A
L
D
V
E
Q
I
R
H
Q
L
E
H
I
L
N
E
E
H
I
A
H
E
P
R
A
L
Q
L
L
A
R
A
A
E
G
S
L
R
D
A
L
S
L
T
D
Q
A
I
A
S
G
D
G
Q
V
-
S
T
Q
A
V
S
A
M
L
G
T
L
D
D
D
Q
A
L
S
L
V
E
A
M
V
E
A
N
G
E
R
V
M
A
L
I
N
E
A
AARG
I
E
-
W
-
E
A
L
L
V
E
M
L
G
L
L
H
R
I
A
M
V
Q
L
S
P
A
A
L
G
N
D
M
A
A
I
E
L
---
R
M
R
E
L
A
R
T
I
P
P
T
D
I
Q
L
Y
Y
Q
T
L
L
I
G
R
K
E
L
P
Y
A
P
D
R
R
M
G
V
E
M
T
L
L
R
A
L
A
-
F
H
P
R
M
P
L
P
E
P
----------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
91.50
38%
-108
- C1 -
3GLG
6
DPO3X_ECOLI
H:
[28-390]
---
L
A
R
K
W
R
P
Q
T
F
A
D
V
V
G
Q
E
H
V
L
T
A
L
A
N
G
L
S
L
G
R
I
H
H
A
Y
L
F
S
G
T
R
G
V
G
K
T
S
I
A
R
L
L
A
K
G
L
N
C
E
T
G
I
T
A
T
P
C
G
V
C
D
N
C
R
E
I
E
Q
G
R
F
V
D
L
I
E
I
D
A
A
S
R
T
K
V
E
D
T
R
D
L
L
D
N
V
Q
Y
A
P
A
R
G
R
F
K
V
Y
L
I
D
E
V
H
M
L
S
R
H
S
F
N
A
L
L
K
T
L
E
E
P
P
E
H
V
K
F
L
L
A
T
A
D
P
Q
K
L
P
V
T
I
L
S
R
C
L
Q
F
H
L
K
A
L
D
V
E
Q
I
R
H
Q
L
E
H
I
L
N
E
E
H
I
A
H
E
P
R
A
L
Q
L
L
A
R
A
A
E
G
S
L
R
D
A
L
S
L
T
D
Q
A
I
A
S
G
D
G
Q
V
-
S
T
Q
A
V
S
A
M
L
G
T
L
D
D
D
Q
A
L
S
L
V
E
A
M
V
E
A
N
G
E
R
V
M
A
L
I
N
E
A
AARG
I
E
-
W
-
E
A
L
L
V
E
M
L
G
L
L
H
R
I
A
M
V
Q
L
S
P
A
A
L
G
N
D
M
A
A
I
E
L
---
R
M
R
E
L
A
R
T
I
P
P
T
D
I
Q
L
Y
Y
Q
T
L
L
I
G
R
K
E
L
P
Y
A
P
D
R
R
M
G
V
E
M
T
L
L
R
A
L
A
-
F
H
P
R
M
P
L
P
E
P
----------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
91.42
38%
-117
- C1 -
1XXI
2
DPO3X_ECOLI
D:
[6-367]
---
L
A
R
K
W
R
P
Q
T
F
A
D
V
V
G
Q
E
H
V
L
T
A
L
A
N
G
L
S
L
G
R
I
H
H
A
Y
L
F
S
G
T
R
G
V
G
K
T
S
I
A
R
L
L
A
K
G
L
N
C
E
T
G
I
T
A
T
P
C
G
V
C
D
N
C
R
E
I
E
Q
G
R
F
V
D
L
I
E
I
D
A
A
S
R
T
K
V
E
D
T
R
D
L
L
D
N
V
Q
Y
A
P
A
R
G
R
F
K
V
Y
L
I
D
E
V
H
M
L
S
R
H
S
F
N
A
L
L
K
T
L
E
E
P
P
E
H
V
K
F
L
L
A
T
T
D
P
Q
K
L
P
V
T
I
L
S
R
C
L
Q
F
H
L
K
A
L
D
V
E
Q
I
R
H
Q
L
E
H
I
L
N
E
E
H
I
A
H
E
P
R
A
L
Q
L
L
A
R
A
A
E
G
S
L
R
D
A
L
S
L
T
D
Q
A
I
A
S
G
D
G
Q
V
-
S
T
Q
A
V
S
A
M
L
G
T
L
D
D
D
Q
A
L
S
L
V
E
A
M
V
E
A
N
G
E
R
V
M
A
L
I
N
E
A
AARG
I
E
-
W
-
E
A
L
L
V
E
M
L
G
L
L
H
R
I
A
M
V
Q
L
S
P
A
A
L
G
N
D
M
A
A
I
E
L
---
R
M
R
E
L
A
R
T
I
P
P
T
D
I
Q
L
Y
Y
Q
T
L
L
I
G
R
K
E
L
P
Y
A
P
D
R
R
M
G
V
E
M
T
L
L
R
A
L
A
-
F
H
P
R
M
P
L
P
E
P
----------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
91.24
38%
-122
- C1 -
1XXI
1
DPO3X_ECOLI
G:
[6-367]
---
L
A
R
K
W
R
P
Q
T
F
A
D
V
V
G
Q
E
H
V
L
T
A
L
A
N
G
L
S
L
G
R
I
H
H
A
Y
L
F
S
G
T
R
G
V
G
K
T
S
I
A
R
L
L
A
K
G
L
N
C
E
T
G
I
T
A
T
P
C
G
V
C
D
N
C
R
E
I
E
Q
G
R
F
V
D
L
I
E
I
D
A
A
S
R
T
K
V
E
D
T
R
D
L
L
D
N
V
Q
Y
A
P
A
R
G
R
F
K
V
Y
L
I
D
E
V
H
M
L
S
R
H
S
F
N
A
L
L
K
T
L
E
E
P
P
E
H
V
K
F
L
L
A
T
T
D
P
Q
K
L
P
V
T
I
L
S
R
C
L
Q
F
H
L
K
A
L
D
V
E
Q
I
R
H
Q
L
E
H
I
L
N
E
E
H
I
A
H
E
P
R
A
L
Q
L
L
A
R
A
A
E
G
S
L
R
D
A
L
S
L
T
D
Q
A
I
A
S
G
D
G
Q
V
-
S
T
Q
A
V
S
A
M
L
G
T
L
D
D
D
Q
A
L
S
L
V
E
A
M
V
E
A
N
G
E
R
V
M
A
L
I
N
E
A
AARG
I
E
-
W
-
E
A
L
L
V
E
M
L
G
L
L
H
R
I
A
M
V
Q
L
S
P
A
A
L
G
N
D
M
A
A
I
E
L
---
R
M
R
E
L
A
R
T
I
P
P
T
D
I
Q
L
Y
Y
Q
T
L
L
I
G
R
K
E
L
P
Y
A
P
D
R
R
M
G
V
E
M
T
L
L
R
A
L
A
-
F
H
P
R
M
P
L
P
E
P
----------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
91.24
38%
-113
- C1 -
3GLF
5
DPO3X_ECOLI
I:
[28-385]
---
L
A
R
K
W
R
P
Q
T
F
A
D
V
V
G
Q
E
H
V
L
T
A
L
A
N
G
L
S
L
G
R
I
H
H
A
Y
L
F
S
G
T
R
G
V
G
K
T
S
I
A
R
L
L
A
K
G
L
N
C
E
T
G
I
T
A
T
P
C
G
V
C
D
N
C
R
E
I
E
Q
G
R
F
V
D
L
I
E
I
D
A
A
S
R
T
K
V
E
D
T
R
D
L
L
D
N
V
Q
Y
A
P
A
R
G
R
F
K
V
Y
L
I
D
E
V
H
M
L
S
R
H
S
F
N
A
L
L
K
T
L
E
E
P
P
E
H
V
K
F
L
L
A
T
T
D
P
Q
K
L
P
V
T
I
L
S
R
C
L
Q
F
H
L
K
A
L
D
V
E
Q
I
R
H
Q
L
E
H
I
L
N
E
E
H
I
A
H
E
P
R
A
L
Q
L
L
A
R
A
A
E
G
S
L
R
D
A
L
S
L
T
D
Q
A
I
A
S
G
D
G
Q
V
-
S
T
Q
A
V
S
A
M
L
G
T
L
D
D
D
Q
A
L
S
L
V
E
A
M
V
E
A
N
G
E
R
V
M
A
L
I
N
E
A
AARG
I
E
-
W
-
E
A
L
L
V
E
M
L
G
L
L
H
R
I
A
M
V
Q
L
S
P
A
A
L
G
N
D
M
A
A
I
E
L
---
R
M
R
E
L
A
R
T
I
P
P
T
D
I
Q
L
Y
Y
Q
T
L
L
I
G
R
K
E
L
P
Y
A
P
D
R
R
M
G
V
E
M
T
L
L
R
A
L
A
-
F
H
P
R
M
---------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
91.24
38%
-123
- C1 -
3GLH
-
DPO3X_ECOLI
B:
[6-368]
---
L
A
R
K
W
R
P
Q
T
F
A
D
V
V
G
Q
E
H
V
L
T
A
L
A
N
G
L
S
L
G
R
I
H
H
A
Y
L
F
S
G
T
R
G
V
G
K
T
S
I
A
R
L
L
A
K
G
L
N
C
E
T
G
I
T
A
T
P
C
G
V
C
D
N
C
R
E
I
E
Q
G
R
F
V
D
L
I
E
I
D
A
A
S
R
T
K
V
E
D
T
R
D
L
L
D
N
V
Q
Y
A
P
A
R
G
R
F
K
V
Y
L
I
D
E
V
H
M
L
S
R
H
S
F
N
A
L
L
K
T
L
E
E
P
P
E
H
V
K
F
L
L
A
T
T
D
P
Q
K
L
P
V
T
I
L
S
R
C
L
Q
F
H
L
K
-
L
D
V
E
Q
I
R
H
Q
L
E
H
I
L
N
E
E
H
I
A
H
E
P
R
A
L
Q
L
L
A
R
A
A
E
G
S
L
R
D
A
L
S
L
T
D
Q
A
I
A
S
G
D
G
Q
V
-
S
T
Q
A
V
S
A
M
L
-
T
L
D
D
D
Q
A
L
S
L
V
E
A
M
V
E
A
N
G
E
R
V
M
A
L
I
N
E
A
A
A
R
G
I
E
-
W
-
E
A
L
L
V
E
M
L
G
L
L
H
R
I
A
M
V
Q
L
S
P
A
A
L
G
N
D
M
A
A
I
E
L
---
R
M
R
E
L
A
R
T
I
P
P
T
D
I
Q
L
Y
Y
Q
T
L
L
I
G
R
K
E
L
P
Y
A
P
D
R
R
M
G
V
E
M
T
L
L
R
A
L
A
-
F
H
P
R
M
P
L
P
E
P
----------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
91.23
38%
-117
- C1 -
1JR3
2
DPO3X_ECOLI
B:
[6-368]
---
L
A
R
K
W
R
P
Q
T
F
A
D
V
V
G
Q
E
H
V
L
T
A
L
A
N
G
L
S
L
G
R
I
H
H
A
Y
L
F
S
G
T
R
G
V
G
K
T
S
I
A
R
L
L
A
K
G
L
N
C
E
T
G
I
T
A
T
P
C
G
V
C
D
N
C
R
E
I
E
Q
G
R
F
V
D
L
I
E
I
D
A
A
S
R
T
K
V
E
D
T
R
D
L
L
D
N
V
Q
Y
A
P
A
R
G
R
F
K
V
Y
L
I
D
E
V
H
M
L
S
R
H
S
F
N
A
L
L
K
T
L
E
E
P
P
E
H
V
K
F
L
L
A
T
T
D
P
Q
K
L
P
V
T
I
L
S
R
C
L
Q
F
H
L
K
A
L
D
V
E
Q
I
R
H
Q
L
E
H
I
L
N
E
E
H
I
A
H
E
P
R
A
L
Q
L
L
A
R
A
A
E
G
S
L
R
D
A
L
S
L
T
D
Q
A
I
A
S
G
D
G
Q
V
-
S
T
Q
A
V
S
A
M
L
G
T
L
D
D
D
Q
A
L
S
L
V
E
A
M
V
E
A
N
G
E
R
V
M
A
L
I
N
E
A
A
A
R
G
I
E
-
W
-
E
A
L
L
V
E
M
L
G
L
L
H
R
I
A
M
V
Q
L
S
P
A
A
L
G
N
D
M
A
A
I
E
L
---
R
M
R
E
L
A
R
T
I
P
P
T
D
I
Q
L
Y
Y
Q
T
L
L
I
G
R
K
E
L
P
Y
A
P
D
R
R
M
G
V
E
M
T
L
L
R
A
L
A
-
F
H
P
R
M
P
L
P
E
P
----------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
91.21
38%
-114
- C1 -
3GLF
5
DPO3X_ECOLI
D:
[28-385]
---
L
A
R
K
W
R
P
Q
T
F
A
D
V
V
G
Q
E
H
V
L
T
A
L
A
N
G
L
S
L
G
R
I
H
H
A
Y
L
F
S
G
T
R
G
V
G
K
T
S
I
A
R
L
L
A
K
G
L
N
C
E
T
G
I
T
A
T
P
C
G
V
C
D
N
C
R
E
I
E
Q
G
R
F
V
D
L
I
E
I
D
A
A
S
R
T
K
V
E
D
T
R
D
L
L
D
N
V
Q
Y
A
P
A
R
G
R
F
K
V
Y
L
I
D
E
V
H
M
L
S
R
H
S
F
N
A
L
L
K
T
L
E
E
P
P
E
H
V
K
F
L
L
A
T
T
D
P
Q
K
L
P
V
T
I
L
S
R
C
L
Q
F
H
L
K
A
L
D
V
E
Q
I
R
H
Q
L
E
H
I
L
N
E
E
H
I
A
H
E
P
R
A
L
Q
L
L
A
R
A
A
E
G
S
L
R
D
A
L
S
L
T
D
Q
A
I
A
S
G
D
G
Q
V
-
S
T
Q
A
V
S
A
M
L
G
T
L
D
D
D
Q
A
L
S
L
V
E
A
M
V
E
A
N
G
E
R
V
M
A
L
I
N
E
A
A
A
R
G
I
E
-
W
-
E
A
L
L
V
E
M
L
G
L
L
H
R
I
A
M
V
Q
L
S
P
A
A
L
G
N
D
M
A
A
I
E
L
---
R
M
R
E
L
A
R
T
I
P
P
T
D
I
Q
L
Y
Y
Q
T
L
L
I
G
R
K
E
L
P
Y
A
P
D
R
R
M
G
V
E
M
T
L
L
R
A
L
A
-
F
H
P
R
M
---------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
91.16
38%
-114
- C1 -
3GLI
5
DPO3X_ECOLI
D:
[28-385]
---
L
A
R
K
W
R
P
Q
T
F
A
D
V
V
G
Q
E
H
V
L
T
A
L
A
N
G
L
S
L
G
R
I
H
H
A
Y
L
F
S
G
T
R
G
V
G
K
T
S
I
A
R
L
L
A
K
G
L
N
C
E
T
G
I
T
A
T
P
C
G
V
C
D
N
C
R
E
I
E
Q
G
R
F
V
D
L
I
E
I
D
A
A
S
R
T
K
V
E
D
T
R
D
L
L
D
N
V
Q
Y
A
P
A
R
G
R
F
K
V
Y
L
I
D
E
V
H
M
L
S
R
H
S
F
N
A
L
L
K
T
L
E
E
P
P
E
H
V
K
F
L
L
A
T
T
D
P
Q
K
L
P
V
T
I
L
S
R
C
L
Q
F
H
L
K
A
L
D
V
E
Q
I
R
H
Q
L
E
H
I
L
N
E
E
H
I
A
H
E
P
R
A
L
Q
L
L
A
R
A
A
E
G
S
L
R
D
A
L
S
L
T
D
Q
A
I
A
S
G
D
G
Q
V
-
S
T
Q
A
V
S
A
M
L
G
T
L
D
D
D
Q
A
L
S
L
V
E
A
M
V
E
A
N
G
E
R
V
M
A
L
I
N
E
A
A
A
R
G
I
E
-
W
-
E
A
L
L
V
E
M
L
G
L
L
H
R
I
A
M
V
Q
L
S
P
A
A
L
G
N
D
M
A
A
I
E
L
---
R
M
R
E
L
A
R
T
I
P
P
T
D
I
Q
L
Y
Y
Q
T
L
L
I
G
R
K
E
L
P
Y
A
P
D
R
R
M
G
V
E
M
T
L
L
R
A
L
A
-
F
H
P
R
M
---------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
90.97
38%
-119
- C1 -
3GLF
4
DPO3X_ECOLI
B:
[28-390]
---
L
A
R
K
W
R
P
Q
T
F
A
D
V
V
G
Q
E
H
V
L
T
A
L
A
N
G
L
S
L
G
R
I
H
H
A
Y
L
F
S
G
T
R
G
V
G
K
T
S
I
A
R
L
L
A
K
G
L
N
C
E
T
G
I
T
A
T
P
C
G
V
C
D
N
C
R
E
I
E
Q
G
R
F
V
D
L
I
E
I
D
A
A
S
R
T
K
V
E
D
T
R
D
L
L
D
N
V
Q
Y
A
P
A
R
G
R
F
K
V
Y
L
I
D
E
V
H
M
L
S
R
H
S
F
N
A
L
L
K
T
L
E
E
P
P
E
H
V
K
F
L
L
A
T
T
D
P
Q
K
L
P
V
T
I
L
S
R
C
L
Q
F
H
L
K
A
L
D
V
E
Q
I
R
H
Q
L
E
H
I
L
N
E
E
H
I
A
H
E
P
R
A
L
Q
L
L
A
R
A
A
E
G
S
L
R
D
A
L
S
L
T
D
Q
A
I
A
S
G
D
G
Q
V
-
S
T
Q
A
V
S
A
M
L
G
T
L
D
D
D
Q
A
L
S
L
V
E
A
M
V
E
A
N
G
E
R
V
M
A
L
I
N
E
A
A
A
R
G
I
E
-
W
-
E
A
L
L
V
E
M
L
G
L
L
H
R
I
A
M
V
Q
L
S
P
A
A
L
G
N
D
M
A
A
I
E
L
---
R
M
R
E
L
A
R
T
I
P
P
T
D
I
Q
L
Y
Y
Q
T
L
L
I
G
R
K
E
L
P
Y
A
P
D
R
R
M
G
V
E
M
T
L
L
R
A
L
A
-
F
H
P
R
M
P
L
P
E
P
----------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
90.60
38%
-108
- C1 -
3GLI
6
DPO3X_ECOLI
C:
[28-390]
---
L
A
R
K
W
R
P
Q
T
F
A
D
V
V
G
Q
E
H
V
L
T
A
L
A
N
G
L
S
L
G
R
I
H
H
A
Y
L
F
S
G
T
R
G
V
G
K
T
S
I
A
R
L
L
A
K
G
L
N
C
E
T
G
I
T
A
T
P
C
G
V
C
D
N
C
R
E
I
E
Q
G
R
F
V
D
L
I
E
I
D
A
A
S
R
T
K
V
E
D
T
R
D
L
L
D
N
V
Q
Y
A
P
A
R
G
R
F
K
V
Y
L
I
D
E
V
H
M
L
S
R
H
S
F
N
A
L
L
K
T
L
E
E
P
P
E
H
V
K
F
L
L
A
T
T
D
P
Q
K
L
P
V
T
I
L
S
R
C
L
Q
F
H
L
K
A
L
D
V
E
Q
I
R
H
Q
L
E
H
I
L
N
E
E
H
I
A
H
E
P
R
A
L
Q
L
L
A
R
A
A
E
G
S
L
R
D
A
L
S
L
T
D
Q
A
I
A
S
G
D
G
Q
V
-
S
T
Q
A
V
S
A
M
L
G
T
L
D
D
D
Q
A
L
S
L
V
E
A
M
V
E
A
N
G
E
R
V
M
A
L
I
N
E
A
A
A
R
G
I
E
-
W
-
E
A
L
L
V
E
M
L
G
L
L
H
R
I
A
M
V
Q
L
S
P
A
A
L
G
N
D
M
A
A
I
E
L
---
R
M
R
E
L
A
R
T
I
P
P
T
D
I
Q
L
Y
Y
Q
T
L
L
I
G
R
K
E
L
P
Y
A
P
D
R
R
M
G
V
E
M
T
L
L
R
A
L
A
-
F
H
P
R
M
P
L
P
E
P
----------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
90.54
38%
-119
- C1 -
3GLF
4
DPO3X_ECOLI
G:
[28-390]
---
L
A
R
K
W
R
P
Q
T
F
A
D
V
V
G
Q
E
H
V
L
T
A
L
A
N
G
L
S
L
G
R
I
H
H
A
Y
L
F
S
G
T
R
G
V
G
K
T
S
I
A
R
L
L
A
K
G
L
N
C
E
T
G
I
T
A
T
P
C
G
V
C
D
N
C
R
E
I
E
Q
G
R
F
V
D
L
I
E
I
D
A
A
S
R
T
K
V
E
D
T
R
D
L
L
D
N
V
Q
Y
A
P
A
R
G
R
F
K
V
Y
L
I
D
E
V
H
M
L
S
R
H
S
F
N
A
L
L
K
T
L
E
E
P
P
E
H
V
K
F
L
L
A
T
T
D
P
Q
K
L
P
V
T
I
L
S
R
C
L
Q
F
H
L
K
A
L
D
V
E
Q
I
R
H
Q
L
E
H
I
L
N
E
E
H
I
A
H
E
P
R
A
L
Q
L
L
A
R
A
A
E
G
S
L
R
D
A
L
S
L
T
D
Q
A
I
A
S
G
D
G
Q
V
-
S
T
Q
A
V
S
A
M
L
G
T
L
D
D
D
Q
A
L
S
L
V
E
A
M
V
E
A
N
G
E
R
V
M
A
L
I
N
E
A
AARG
I
E
-
W
-
E
A
L
L
V
E
M
L
G
L
L
H
R
I
A
M
V
Q
L
S
P
A
A
L
G
N
D
M
A
A
I
E
L
---
R
M
R
E
L
A
R
T
I
P
P
T
D
I
Q
L
Y
Y
Q
T
L
L
I
G
R
K
E
L
P
Y
A
P
D
R
R
M
G
V
E
M
T
L
L
R
A
L
A
-
F
H
P
R
M
P
L
P
E
P
----------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
90.51
38%
-120
- C1 -
3GLG
4
DPO3X_ECOLI
B:
[28-390]
---
L
A
R
K
W
R
P
Q
T
F
A
D
V
V
G
Q
E
H
V
L
T
A
L
A
N
G
L
S
L
G
R
I
H
H
A
Y
L
F
S
G
T
R
G
V
G
K
T
S
I
A
R
L
L
A
K
G
L
N
C
E
T
G
I
T
A
T
P
C
G
V
C
D
N
C
R
E
I
E
Q
G
R
F
V
D
L
I
E
I
D
A
A
S
R
T
K
V
E
D
T
R
D
L
L
D
N
V
Q
Y
A
P
A
R
G
R
F
K
V
Y
L
I
D
E
V
H
M
L
S
R
H
S
F
N
A
L
L
K
T
L
E
E
P
P
E
H
V
K
F
L
L
A
T
A
D
P
Q
K
L
P
V
T
I
L
S
R
C
L
Q
F
H
L
K
A
L
D
V
E
Q
I
R
H
Q
L
E
H
I
L
N
E
E
H
I
A
H
E
P
R
A
L
Q
L
L
A
R
A
A
E
G
S
L
R
D
A
L
S
L
T
D
Q
A
I
A
S
G
D
G
Q
V
-
S
T
Q
A
V
S
A
M
L
G
T
L
D
D
D
Q
A
L
S
L
V
E
A
M
V
E
A
N
G
E
R
V
M
A
L
I
N
E
A
A
A
R
G
I
E
-
W
-
E
A
L
L
V
E
M
L
G
L
L
H
R
I
A
M
V
Q
L
S
P
A
A
L
G
N
D
M
A
A
I
E
L
---
R
M
R
E
L
A
R
T
I
P
P
T
D
I
Q
L
Y
Y
Q
T
L
L
I
G
R
K
E
L
P
Y
A
P
D
R
R
M
G
V
E
M
T
L
L
R
A
L
A
-
F
H
P
R
M
P
L
P
E
P
----------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
90.34
38%
-114
- C1 -
3GLG
5
DPO3X_ECOLI
D:
[28-385]
---
L
A
R
K
W
R
P
Q
T
F
A
D
V
V
G
Q
E
H
V
L
T
A
L
A
N
G
L
S
L
G
R
I
H
H
A
Y
L
F
S
G
T
R
G
V
G
K
T
S
I
A
R
L
L
A
K
G
L
N
C
E
T
G
I
T
A
T
P
C
G
V
C
D
N
C
R
E
I
E
Q
G
R
F
V
D
L
I
E
I
D
A
A
S
R
T
K
V
E
D
T
R
D
L
L
D
N
V
Q
Y
A
P
A
R
G
R
F
K
V
Y
L
I
D
E
V
H
M
L
S
R
H
S
F
N
A
L
L
K
T
L
E
E
P
P
E
H
V
K
F
L
L
A
T
A
D
P
Q
K
L
P
V
T
I
L
S
R
C
L
Q
F
H
L
K
A
L
D
V
E
Q
I
R
H
Q
L
E
H
I
L
N
E
E
H
I
A
H
E
P
R
A
L
Q
L
L
A
R
A
A
E
G
S
L
R
D
A
L
S
L
T
D
Q
A
I
A
S
G
D
G
Q
V
-
S
T
Q
A
V
S
A
M
L
G
T
L
D
D
D
Q
A
L
S
L
V
E
A
M
V
E
A
N
G
E
R
V
M
A
L
I
N
E
A
A
A
R
G
I
E
-
W
-
E
A
L
L
V
E
M
L
G
L
L
H
R
I
A
M
V
Q
L
S
P
A
A
L
G
N
D
M
A
A
I
E
L
---
R
M
R
E
L
A
R
T
I
P
P
T
D
I
Q
L
Y
Y
Q
T
L
L
I
G
R
K
E
L
P
Y
A
P
D
R
R
M
G
V
E
M
T
L
L
R
A
L
A
-
F
H
P
R
M
---------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
90.34
38%
-115
- C1 -
3GLI
3
DPO3X_ECOLI
I:
[28-385]
---
L
A
R
K
W
R
P
Q
T
F
A
D
V
V
G
Q
E
H
V
L
T
A
L
A
N
G
L
S
L
G
R
I
H
H
A
Y
L
F
S
G
T
R
G
V
G
K
T
S
I
A
R
L
L
A
K
G
L
N
C
E
T
G
I
T
A
T
P
C
G
V
C
D
N
C
R
E
I
E
Q
G
R
F
V
D
L
I
E
I
D
A
A
S
R
T
K
V
E
D
T
R
D
L
L
D
N
V
Q
Y
A
P
A
R
G
R
F
K
V
Y
L
I
D
E
V
H
M
L
S
R
H
S
F
N
A
L
L
K
T
L
E
E
P
P
E
H
V
K
F
L
L
A
T
T
D
P
Q
K
L
P
V
T
I
L
S
R
C
L
Q
F
H
L
K
A
L
D
V
E
Q
I
R
H
Q
L
E
H
I
L
N
E
E
H
I
A
H
E
P
R
A
L
Q
L
L
A
R
A
A
E
G
S
L
R
D
A
L
S
L
T
D
Q
A
I
A
S
G
D
G
Q
V
-
S
T
Q
A
V
S
A
M
L
G
T
L
D
D
D
Q
A
L
S
L
V
E
A
M
V
E
A
N
G
E
R
V
M
A
L
I
N
E
A
AARG
I
E
-
W
-
E
A
L
L
V
E
M
L
G
L
L
H
R
I
A
M
V
Q
L
S
P
A
A
L
G
N
D
M
A
A
I
E
L
---
R
M
R
E
L
A
R
T
I
P
P
T
D
I
Q
L
Y
Y
Q
T
L
L
I
G
R
K
E
L
P
Y
A
P
D
R
R
M
G
V
E
M
T
L
L
R
A
L
A
-
F
H
P
R
M
---------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
90.32
38%
-118
- C1 -
3GLG
4
DPO3X_ECOLI
G:
[28-390]
---
L
A
R
K
W
R
P
Q
T
F
A
D
V
V
G
Q
E
H
V
L
T
A
L
A
N
G
L
S
L
G
R
I
H
H
A
Y
L
F
S
G
T
R
G
V
G
K
T
S
I
A
R
L
L
A
K
G
L
N
C
E
T
G
I
T
A
T
P
C
G
V
C
D
N
C
R
E
I
E
Q
G
R
F
V
D
L
I
E
I
D
A
A
S
R
T
K
V
E
D
T
R
D
L
L
D
N
V
Q
Y
A
P
A
R
G
R
F
K
V
Y
L
I
D
E
V
H
M
L
S
R
H
S
F
N
A
L
L
K
T
L
E
E
P
P
E
H
V
K
F
L
L
A
T
A
D
P
Q
K
L
P
V
T
I
L
S
R
C
L
Q
F
H
L
K
A
L
D
V
E
Q
I
R
H
Q
L
E
H
I
L
N
E
E
H
I
A
H
E
P
R
A
L
Q
L
L
A
R
A
A
E
G
S
L
R
D
A
L
S
L
T
D
Q
A
I
A
S
G
D
G
Q
V
-
S
T
Q
A
V
S
A
M
L
G
T
L
D
D
D
Q
A
L
S
L
V
E
A
M
V
E
A
N
G
E
R
V
M
A
L
I
N
E
A
AARG
I
E
-
W
-
E
A
L
L
V
E
M
L
G
L
L
H
R
I
A
M
V
Q
L
S
P
A
A
L
G
N
D
M
A
A
I
E
L
---
R
M
R
E
L
A
R
T
I
P
P
T
D
I
Q
L
Y
Y
Q
T
L
L
I
G
R
K
E
L
P
Y
A
P
D
R
R
M
G
V
E
M
T
L
L
R
A
L
A
-
F
H
P
R
M
P
L
P
E
P
----------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
89.39
38%
-123
- C1 -
3GLI
4
DPO3X_ECOLI
B:
[28-385]
---
L
A
R
K
W
R
P
Q
T
F
A
D
V
V
G
Q
E
H
V
L
T
A
L
A
N
G
L
S
L
G
R
I
H
H
A
Y
L
F
S
G
T
R
G
V
G
K
T
S
I
A
R
L
L
A
K
G
L
N
C
E
T
G
I
T
A
T
P
C
G
V
C
D
N
C
R
E
I
E
Q
G
R
F
V
D
L
I
E
I
D
A
A
S
R
T
K
V
E
D
T
R
D
L
L
D
N
V
Q
Y
A
P
A
R
G
R
F
K
V
Y
L
I
D
E
V
H
M
L
S
R
H
S
F
N
A
L
L
K
T
L
E
E
P
P
E
H
V
K
F
L
L
A
T
T
D
P
Q
K
L
P
V
T
I
L
S
R
C
L
Q
F
H
L
K
A
L
D
V
E
Q
I
R
H
Q
L
E
H
I
L
N
E
E
H
I
A
H
E
P
R
A
L
Q
L
L
A
R
A
A
E
G
S
L
R
D
A
L
S
L
T
D
Q
A
I
A
S
G
D
G
Q
V
-
S
T
Q
A
V
S
A
M
L
G
T
L
D
D
D
Q
A
L
S
L
V
E
A
M
V
E
A
N
G
E
R
V
M
A
L
I
N
E
A
A
A
R
G
I
E
-
W
-
E
A
L
L
V
E
M
L
G
L
L
H
R
I
A
M
V
Q
L
S
P
A
A
L
G
N
D
M
A
A
I
E
L
---
R
M
R
E
L
A
R
T
I
P
P
T
D
I
Q
L
Y
Y
Q
T
L
L
I
G
R
K
E
L
P
Y
A
P
D
R
R
M
G
V
E
M
T
L
L
R
A
L
A
-
F
H
P
R
M
---------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
89.13
38%
-121
- C1 -
3GLI
4
DPO3X_ECOLI
G:
[28-385]
---
L
A
R
K
W
R
P
Q
T
F
A
D
V
V
G
Q
E
H
V
L
T
A
L
A
N
G
L
S
L
G
R
I
H
H
A
Y
L
F
S
G
T
R
G
V
G
K
T
S
I
A
R
L
L
A
K
G
L
N
C
E
T
G
I
T
A
T
P
C
G
V
C
D
N
C
R
E
I
E
Q
G
R
F
V
D
L
I
E
I
D
A
A
S
R
T
K
V
E
D
T
R
D
L
L
D
N
V
Q
Y
A
P
A
R
G
R
F
K
V
Y
L
I
D
E
V
H
M
L
S
R
H
S
F
N
A
L
L
K
T
L
E
E
P
P
E
H
V
K
F
L
L
A
T
T
D
P
Q
K
L
P
V
T
I
L
S
R
C
L
Q
F
H
L
K
A
L
D
V
E
Q
I
R
H
Q
L
E
H
I
L
N
E
E
H
I
A
H
E
P
R
A
L
Q
L
L
A
R
A
A
E
G
S
L
R
D
A
L
S
L
T
D
Q
A
I
A
S
G
D
G
Q
V
-
S
T
Q
A
V
S
A
M
L
G
T
L
D
D
D
Q
A
L
S
L
V
E
A
M
V
E
A
N
G
E
R
V
M
A
L
I
N
E
A
AARG
I
E
-
W
-
E
A
L
L
V
E
M
L
G
L
L
H
R
I
A
M
V
Q
L
S
P
A
A
L
G
N
D
M
A
A
I
E
L
---
R
M
R
E
L
A
R
T
I
P
P
T
D
I
Q
L
Y
Y
Q
T
L
L
I
G
R
K
E
L
P
Y
A
P
D
R
R
M
G
V
E
M
T
L
L
R
A
L
A
-
F
H
P
R
M
---------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
79.18
47%
-111
- C1 -
1NJF
3
DPO3X_ECOLI
B:
[13-249]
---
L
A
R
K
W
R
P
Q
T
F
A
D
V
V
G
Q
E
H
V
L
T
A
L
A
N
G
L
S
L
G
R
I
H
H
A
Y
L
F
S
G
T
R
G
V
G
K
T
S
I
A
R
L
L
A
K
G
L
N
C
E
T
G
I
T
A
T
P
C
G
V
C
D
N
C
R
E
I
E
Q
G
R
F
V
D
L
I
E
I
D
A
A
S
R
T
K
V
E
D
T
R
D
L
L
D
N
V
Q
Y
A
P
A
R
G
R
F
K
V
Y
L
I
D
E
V
H
M
L
S
R
H
S
F
N
A
L
L
K
T
L
E
E
P
P
E
H
V
K
F
L
L
A
T
T
D
P
Q
K
L
P
V
T
I
L
S
R
C
L
Q
F
H
L
K
A
L
D
V
E
Q
I
R
H
Q
L
E
H
I
L
N
E
E
H
I
A
H
E
P
R
A
L
Q
L
L
A
R
A
A
E
G
S
L
R
D
A
L
S
L
T
D
Q
A
I
A
S
G
D
G
Q
V
-
S
T
Q
A
V
S
A
M
L
G
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
77.66
47%
-112
- C1 -
1NJF
3
DPO3X_ECOLI
A:
[13-249]
---
L
A
R
K
W
R
P
Q
T
F
A
D
V
V
G
Q
E
H
V
L
T
A
L
A
N
G
L
S
L
G
R
I
H
H
A
Y
L
F
S
G
T
R
G
V
G
K
T
S
I
A
R
L
L
A
K
G
L
N
C
E
T
G
I
T
A
T
P
C
G
V
C
D
N
C
R
E
I
E
Q
G
R
F
V
D
L
I
E
I
D
A
A
S
R
T
K
V
E
D
T
R
D
L
L
D
N
V
Q
Y
A
P
A
R
G
R
F
K
V
Y
L
I
D
E
V
H
M
L
S
R
H
S
F
N
A
L
L
K
T
L
E
E
P
P
E
H
V
K
F
L
L
A
T
T
D
P
Q
K
L
P
V
T
I
L
S
R
C
L
Q
F
H
L
K
A
L
D
V
E
Q
I
R
H
Q
L
E
H
I
L
N
E
E
H
I
A
H
E
P
R
A
L
Q
L
L
A
R
A
A
E
G
S
L
R
D
A
L
S
L
T
D
Q
A
I
A
S
G
D
G
Q
V
-
S
T
Q
A
V
S
A
M
L
G
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
76.73
47%
-111
- C1 -
1NJF
3
DPO3X_ECOLI
C:
[13-249]
---
L
A
R
K
W
R
P
Q
T
F
A
D
V
V
G
Q
E
H
V
L
T
A
L
A
N
G
L
S
L
G
R
I
H
H
A
Y
L
F
S
G
T
R
G
V
G
K
T
S
I
A
R
L
L
A
K
G
L
N
C
E
T
G
I
T
A
T
P
C
G
V
C
D
N
C
R
E
I
E
Q
G
R
F
V
D
L
I
E
I
D
A
A
S
R
T
K
V
E
D
T
R
D
L
L
D
N
V
Q
Y
A
P
A
R
G
R
F
K
V
Y
L
I
D
E
V
H
M
L
S
R
H
S
F
N
A
L
L
K
T
L
E
E
P
P
E
H
V
K
F
L
L
A
T
T
D
P
Q
K
L
P
V
T
I
L
S
R
C
L
Q
F
H
L
K
A
L
D
V
E
Q
I
R
H
Q
L
E
H
I
L
N
E
E
H
I
A
H
E
P
R
A
L
Q
L
L
A
R
A
A
E
G
S
L
R
D
A
L
S
L
T
D
Q
A
I
A
S
G
D
G
Q
V
-
S
T
Q
A
V
S
A
M
L
G
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------