@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0472: (2015-12-01 )
MIRITFLAKQKVEEYSSRVTGFDILQPDISKEAIALRVNGELYDLSREIESDTEIDVIQLNDEEGLDIIRHDAAHIMAQAVKELFPNAQVTIGPTIQDGFYYDFAIDHTFTTDDLAAIEKKMKEIIKSNHRFIREVWARKQAINFFSSIGEKYKVDIISSIPESEDLTVYRQGDFVDLCRGPHSPSTSRVKAFKLMKVAGAYWRGNVKGPMLQRIYGTAWRNKDELNIYLKRLEEAKKRDHRRIAKDMDLFHIQEEAVGQVFWHEQGYTLYNVLESYIRKKLINNGYAEVKTPILVSKELWEKSGHWDKFRENMFIVDESESKKLAIKPMNCPCHVQIFNSYTRSYRNLPIRMAEFGMCHRNESSGSLHGLMRVRGFTQDDAHIFCMEEQVNSETVKFCALLKEVYSELGFNEISVKFSDRPNVRAGDNEVWDRAEKALLEAVKEAGLSYELNPGEGAFYGPKLEFILKDAIGRSWQCGTLQVDFILPERLGAFYIGADGQKYHPVMLHRAILGTFERFIGILIEHYAGKFPLWLAPTQLVILTVTNEADNYATEISNVLKEQGVRVKTDLTNEKVSYKIRLHSSNKVPILWIVGKNEVASKTVSVRNLGSEKQESSSCEKAVKLLLKKVLI
Atome Classification :
(29 SA)
.......-..10........20...---..---...30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......-160.-......170.......180.......190.......200.......210.......220.......230.......240.......250.......-.260.......270.......-280-.......290.......300.......310....---...320...-.....330.......340.......350.......360.......370.......380.......390.......400......-.----410---.......420.----....---...430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.....---.---.550........560--------------.--------------......570.......580.......590.......600.....-----..610..-.....620.......630
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
I
R
I
T
F
L
-
A
K
Q
K
V
E
E
Y
S
S
RVT
G
F
DI---LQ---PDISK
E
A
I
A
L
R
VN
G
E
L
Y
D
L
S
R
EIESDT
E
I
D
V
I
Q
LNDEEG
L
D
I
I
R
H
D
A
A
H
I
M
A
Q
A
V
K
E
LFPNA
Q
V
T
IGPTIQD
G
F
Y
Y
D
F
A
IDHTFT
T
D
D
L
A
A
I
E
K
K
M
K
E
I
I
K
S
N
H
R
F
I
R
E
V
W
A
R
K
Q
A
I
N
F
F
S
SIGE
K
Y
K
V
D
I
I
S-SIPE-SE
D
L
T
V
Y
RQGD
F
V
D
LCRGPHSPST
S
R
V
K
A
F
K
L
M
KVA
G
A
Y
WRGNVK
G
P
M
L
Q
R
I
Y
G
TAWR
N
K
D
E
L
N
I
Y
L
K
R
L
E
E
A
K
K
R
D
H
R
R
I
A
K
DM
D
L
F
-
H
I
Q
E
E
AV-
G
Q
V
F
WHEQG
Y
T
L
Y
N
V
L
E
S
Y
I
R
-
K
K
L
-
I
NNGYAEVKT
P
I
L
V
S
K
E
L
W
E
KSG
H
W
D
K
F
RE
N
M
F
I
---
V
DES-ES
K
K
-
L
A
I
KPMNC
P
C
H
V
Q
I
F
N
S
Y
T
R
S
YRNLP
I
R
M
A
E
FGMCHRNESSG
S
L
H
G
L
M
R
VRGFTQDD
A
H
I
F
C
M
E
E
QVN
S
E
T
V
K
F
C
A
L
L
K
E
V
Y
S
E-L----GF
N
---
E
I
S
V
K
FSDR-P----NVRA---GD
N
E
V
W
D
R
A
E
K
A
L
L
E
A
V
K
EAG
L
S
Y
ELNPGEGAFYG
P
K
L
E
F
I
L
K
D
AIGRSWQC
G
T
L
Q
V
D
F
I
LPERL
G
A
F
Y
IGADGQKY
H
P
V
M
L
H
R
A
I
L
G
T
F
E
R
F
I
G
I
L
I
E
H
YAGKF
P
L
W
LAP
T
Q
L
V
I
L
T
VTN---E---AD-
N
Y
A
T
E
I
S
N
V
L
K
E--------------Q--------------G
V
R
V
K
TDLTNE
K
V
S
Y
K
I
R
LHSSNKV
P
I
L
W
I
VGKNEVAS
K
T
V
S
VR-----NLGSEK
Q
-
E
S
S
S
C
E
K
A
V
K
L
L
L
K
K
VLI
54
HHSearch
94.62
49%
-98
- C1 -
1QF6
2
SYT_ECOLI
A:
[2-633]
-
P
V
I
T
L
P
--
D
G
S
Q
R
H
Y
D
H
A
V
S
P
M
D
V
---
A
L
D
I
G
P
G
L
A
K
A
C
I
A
G
R
V
N
G
E
L
V
D
A
C
D
L
I
E
N
D
A
Q
L
S
I
I
T
A
K
D
E
E
G
L
E
I
I
R
H
S
C
A
H
L
L
G
H
A
I
K
Q
L
W
P
H
T
K
M
A
I
G
P
V
I
D
N
G
F
Y
Y
D
V
D
L
D
R
T
L
T
Q
E
D
V
E
A
L
E
K
R
M
H
E
L
A
E
K
N
Y
D
V
I
K
K
K
V
S
W
H
E
A
R
E
T
F
A
N
R
G
E
S
Y
K
V
S
I
L
D
-
E
N
I
A
H
D
D
K
P
G
L
Y
F
H
E
E
Y
V
D
M
C
R
G
P
H
V
P
N
M
R
F
C
H
H
F
K
L
M
K
T
A
G
A
Y
W
R
G
D
S
N
N
K
M
L
Q
R
I
Y
G
T
A
W
A
D
K
K
A
L
N
A
Y
L
Q
R
L
E
E
A
A
K
R
D
H
R
K
I
G
K
Q
L
D
L
Y
-
H
M
Q
E
E
A
P
-
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
-
S
K
L
-
K
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
T
---
T
S
S
--
E
N
R
E
-
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
S
T
-
F
----
G
F
E
---
K
I
V
V
K
L
S
T
R
-
P
----
E
K
R
I
---
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
E
D
N
E
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
D
---
S
---
Q
S
-
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
--------------
G
I
R
V
K
A
D
L
R
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
-----
T
R
R
G
K
D
L
-
G
S
M
D
V
N
E
V
I
E
K
L
Q
Q
E
I
R
S
1
PsiBlast_PDB
92.37
51%
-98
- C2 -
1QF6
2
SYT_ECOLI
A:
[14-618]
---------------
Y
D
H
A
V
S
P
M
D
V
A
L
D
I
G
---
P
G
L
A
K
A
C
I
A
G
R
V
N
G
E
L
V
D
A
C
D
L
I
E
N
D
A
Q
L
S
I
I
T
A
K
D
E
E
G
L
E
I
I
R
H
S
C
A
H
L
L
G
H
A
I
K
Q
L
W
P
H
T
K
M
A
I
G
P
V
I
D
N
G
F
Y
Y
D
V
D
L
D
R
T
L
T
Q
E
D
V
E
A
L
E
K
R
M
H
E
L
A
E
K
N
Y
D
V
I
K
K
K
V
S
W
H
E
A
R
E
T
F
A
N
R
G
E
S
Y
K
V
S
I
L
D
E
N
I
A
H
-
D
D
K
P
G
L
Y
F
H
E
E
Y
V
D
M
C
R
G
P
H
V
P
N
M
R
F
C
H
H
F
K
L
M
K
T
A
G
A
Y
W
R
G
D
S
N
N
K
M
L
Q
R
I
Y
G
T
A
W
A
D
K
K
A
L
N
A
Y
L
Q
R
L
E
E
A
A
K
R
D
H
R
K
I
G
K
Q
L
D
L
Y
-
H
M
Q
E
E
A
P
-
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
-
S
K
L
-
K
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
T
---
T
-
S
S
-
E
N
R
E
-
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
S
T
-
F
----
G
F
E
---
K
I
V
V
K
L
S
T
R
-
P
----
E
K
R
I
---
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
E
D
N
E
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
D
---
S
---
Q
S
-
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
--------------
G
I
R
V
K
A
D
L
R
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
RRGK
D
L
G
S
M
D
V
-
N
E
V
I
E
K
L
Q
Q
E
I
R
S
R
S
L
K
Q
55
HHSearch
88.59
43%
-95
- C1 -
1NYR
4
SYT_STAAW
A:
[4-640]
---
I
N
I
Q
F
P
D
G
N
K
K
A
F
D
K
G
T
T
T
E
D
I
---
A
Q
S
I
S
P
G
L
R
K
K
A
V
A
G
K
F
N
G
Q
L
V
D
L
T
K
P
L
E
T
D
G
S
I
E
I
V
T
P
G
S
E
E
A
L
E
V
L
R
H
S
T
A
H
L
M
A
H
A
I
K
R
L
Y
G
N
V
K
F
G
V
G
P
V
I
E
G
G
F
Y
Y
D
F
D
I
D
Q
N
I
S
S
D
D
F
E
Q
I
E
K
T
M
K
Q
I
V
N
E
N
M
K
I
E
R
K
V
V
S
R
D
E
A
K
E
L
F
S
N
--
D
E
Y
K
L
E
L
I
D
-
A
I
P
E
-
D
E
N
V
T
L
Y
S
Q
G
D
F
T
D
L
C
R
G
V
H
V
P
S
T
A
K
I
K
E
F
K
L
L
S
T
A
G
A
Y
W
R
G
D
S
N
N
K
M
L
Q
R
I
Y
G
T
A
F
F
D
K
K
E
L
K
A
H
L
Q
M
L
E
E
R
K
E
R
D
H
R
K
I
G
K
E
L
E
L
F
-
T
N
S
Q
L
V
G
A
G
L
P
L
W
L
P
N
G
A
T
I
R
R
E
I
E
R
Y
I
V
-
D
K
E
-
V
S
M
G
Y
D
H
V
Y
T
P
V
L
A
N
V
D
L
Y
K
T
S
G
H
W
D
H
Y
Q
E
D
M
F
P
---
P
M
Q
L
D
E
T
E
S
-
M
V
L
R
P
M
N
C
P
H
H
M
M
I
Y
A
N
K
P
H
S
Y
R
E
L
P
I
R
I
A
E
L
G
T
M
H
R
Y
E
A
S
G
A
V
S
G
L
Q
R
V
R
G
M
T
L
N
D
S
H
I
F
V
R
P
D
Q
I
K
E
E
F
K
R
V
V
N
M
I
I
D
V
Y
K
D
-
F
----
G
F
E
---
D
Y
S
F
R
L
S
Y
R
-
D
P
EDK
E
K
Y
F
---
D
D
D
D
M
W
N
K
A
E
N
M
L
K
E
A
A
D
E
L
G
L
S
Y
E
E
A
I
G
E
A
A
F
Y
G
P
K
L
D
V
Q
V
K
T
A
M
G
K
E
E
T
L
S
T
A
Q
L
D
F
L
L
P
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R
F
D
L
T
Y
I
G
Q
D
G
E
H
H
R
P
V
V
I
H
R
G
V
V
S
T
M
E
R
F
V
A
F
L
T
E
E
T
K
G
A
F
P
T
W
L
A
P
K
Q
V
Q
I
I
P
V
N
V
D--
L
---
H
Y
-
D
Y
A
R
Q
L
Q
D
E
L
K
S
--------------
Q
--------------
G
V
R
V
S
I
D
D
R
N
E
K
M
G
Y
K
I
R
E
A
Q
M
Q
K
I
P
Y
Q
I
V
V
G
D
K
E
V
E
N
N
Q
V
N
V
R
-----
Q
Y
G
S
Q
D
Q
-
E
T
V
E
K
D
E
F
I
W
N
L
V
D
E
I
R
L
3
PsiBlast_PDB
85.29
44%
-94
- C1 -
1NYR
4
SYT_STAAW
A:
[29-625]
----------------------------
I
S
---
P
G
L
R
K
K
A
V
A
G
K
F
N
G
Q
L
V
D
L
T
K
P
L
E
T
D
G
S
I
E
I
V
T
P
G
S
E
E
A
L
E
V
L
R
H
S
T
A
H
L
M
A
H
A
I
K
R
L
Y
G
N
V
K
F
G
V
G
P
V
I
E
G
G
F
Y
Y
D
F
D
I
D
Q
N
I
S
S
D
D
F
E
Q
I
E
K
T
M
K
Q
I
V
N
E
N
M
K
I
E
R
K
V
V
S
R
D
E
A
K
E
L
F
S
N
--
D
E
Y
K
L
E
L
I
D
-
A
I
P
E
-
D
E
N
V
T
L
Y
S
Q
G
D
F
T
D
L
C
R
G
V
H
V
P
S
T
A
K
I
K
E
F
K
L
L
S
T
A
G
A
Y
W
R
G
D
S
N
N
K
M
L
Q
R
I
Y
G
T
A
F
F
D
K
K
E
L
K
A
H
L
Q
M
L
E
E
R
K
E
R
D
H
R
K
I
G
K
E
L
E
L
F
T
N
S
Q
L
V
G
A
-
G
L
P
L
W
L
P
N
G
A
T
I
R
R
E
I
E
R
Y
I
V
-
D
K
E
-
V
S
M
G
Y
D
H
V
Y
T
P
V
L
A
N
V
D
L
Y
K
T
S
G
H
W
D
H
Y
Q
E
D
M
F
P
PMQ
L
D
E
T
-
E
S
---
M
V
L
R
P
M
N
C
P
H
H
M
M
I
Y
A
N
K
P
H
S
Y
R
E
L
P
I
R
I
A
E
L
G
T
M
H
R
Y
E
A
S
G
A
V
S
G
L
Q
R
V
R
G
M
T
L
N
D
S
H
I
F
V
R
P
D
Q
I
K
E
E
F
K
R
V
V
N
M
I
I
D
V
Y
K
D
-
F
----
G
F
E
---
D
Y
S
F
R
L
S
Y
R
D
P
----
E
D
K
E
KYF
D
D
D
D
M
W
N
K
A
E
N
M
L
K
E
A
A
D
E
L
G
L
S
Y
E
E
A
I
G
E
A
A
F
Y
G
P
K
L
D
V
Q
V
K
T
A
M
G
K
E
E
T
L
S
T
A
Q
L
D
F
L
L
P
E
R
F
D
L
T
Y
I
G
Q
D
G
E
H
H
R
P
V
V
I
H
R
G
V
V
S
T
M
E
R
F
V
A
F
L
T
E
E
T
K
G
A
F
P
T
W
L
A
P
K
Q
V
Q
I
I
P
V
N
V
---
D
---
L
H
Y
D
Y
A
R
Q
L
Q
D
E
L
K
S
--------------
Q
--------------
G
V
R
V
S
I
D
D
R
N
E
K
M
G
Y
K
I
R
E
A
Q
M
Q
K
I
P
Y
Q
I
V
V
G
D
K
E
V
E
N
N
Q
V
N
V
R
-----
Q
Y
G
S
Q
D
Q
-
E
T
V
E
K
D
E
F
I
W
N
L
V
D
E
I
R
L
2
PsiBlast_PDB
83.81
44%
-94
- C1 -
1NYQ
2
SYT_STAAW
A:
[29-625]
----------------------------
I
S
---
P
G
L
R
K
K
A
V
A
G
K
F
N
G
Q
L
V
D
L
T
K
P
L
E
T
D
G
S
I
E
I
V
T
P
G
S
E
E
A
L
E
V
L
R
H
S
T
A
H
L
M
A
H
A
I
K
R
L
Y
G
N
V
K
F
G
V
G
P
V
I
E
G
G
F
Y
Y
D
F
D
I
D
Q
N
I
S
S
D
D
F
E
Q
I
E
K
T
M
K
Q
I
V
N
E
N
M
K
I
E
R
K
V
V
S
R
D
E
A
K
E
L
F
S
N
--
D
E
Y
K
L
E
L
I
D
-
A
I
P
E
-
D
E
N
V
T
L
Y
S
Q
G
D
F
T
D
L
C
R
G
V
H
V
P
S
T
A
K
I
K
E
F
K
L
L
S
T
A
G
A
Y
W
R
G
D
S
N
N
K
M
L
Q
R
I
Y
G
T
A
F
F
D
K
K
E
L
K
A
H
L
Q
M
L
E
E
R
K
E
R
D
H
R
K
I
G
K
E
L
E
L
F
T
N
S
Q
L
V
G
A
-
G
L
P
L
W
L
P
N
G
A
T
I
R
R
E
I
E
R
Y
I
V
-
D
K
E
-
V
S
M
G
Y
D
H
V
Y
T
P
V
L
A
N
V
D
L
Y
K
T
S
G
H
W
D
H
Y
Q
E
D
M
F
P
PMQ
L
D
E
T
-
E
S
---
M
V
L
R
P
M
N
C
P
H
H
M
M
I
Y
A
N
K
P
H
S
Y
R
E
L
P
I
R
I
A
E
L
G
T
M
H
R
Y
E
A
S
G
A
V
S
G
L
Q
R
V
R
G
M
T
L
N
D
S
H
I
F
V
R
P
D
Q
I
K
E
E
F
K
R
V
V
N
M
I
I
D
V
Y
K
D
-
F
----
G
F
E
---
D
Y
S
F
R
L
S
Y
R
D
P
----
E
D
K
E
KYF
D
D
D
D
M
W
N
K
A
E
N
M
L
K
E
A
A
D
E
L
G
L
S
Y
E
E
A
I
G
E
A
A
F
Y
G
P
K
L
D
V
Q
V
K
T
A
M
G
K
E
E
T
L
S
T
A
Q
L
D
F
L
L
P
E
R
F
D
L
T
Y
I
G
Q
D
G
E
H
H
R
P
V
V
I
H
R
G
V
V
S
T
M
E
R
F
V
A
F
L
T
E
E
T
K
G
A
F
P
T
W
L
A
P
K
Q
V
Q
I
I
P
V
N
V
---
D
---
L
H
Y
D
Y
A
R
Q
L
Q
D
E
L
K
S
--------------
Q
--------------
G
V
R
V
S
I
D
D
R
N
E
K
M
G
Y
K
I
R
E
A
Q
M
Q
K
I
P
Y
Q
I
V
V
G
D
K
E
V
E
N
N
Q
V
N
V
R
-----
Q
Y
G
S
Q
D
Q
-
E
T
V
E
K
D
E
F
I
W
N
L
V
D
E
I
R
L
21
PsiBlast_CBE
82.71
44%
-90
- C2 -
1NYR
3
SYT_STAAW
B:
[29-625]
----------------------------
I
S
---
P
G
L
R
K
K
A
V
A
G
K
F
N
G
Q
L
V
D
L
T
K
P
L
E
T
D
G
S
I
E
I
V
T
P
G
S
E
E
A
L
E
V
L
R
H
S
T
A
H
L
M
A
H
A
I
K
R
L
Y
G
N
V
K
F
G
V
G
P
V
I
E
G
G
F
Y
Y
D
F
D
I
D
Q
N
I
S
S
D
D
F
E
Q
I
E
K
T
M
K
Q
I
V
N
E
N
M
K
I
E
R
K
V
V
S
R
D
E
A
K
E
L
----------
E
L
I
D
-
A
I
P
E
-
D
E
N
V
T
L
Y
S
Q
G
D
F
T
D
L
C
R
G
V
H
V
P
S
T
A
K
I
K
E
F
K
L
L
S
T
A
G
A
Y
W
R
G
D
S
N
N
K
M
L
Q
R
I
Y
G
T
A
F
F
D
K
K
E
L
K
A
H
L
Q
M
L
E
E
R
K
E
R
D
H
R
K
I
G
K
E
L
E
L
F
T
N
S
Q
L
V
G
A
-
G
L
P
L
W
L
P
N
G
A
T
I
R
R
E
I
E
R
Y
I
V
-
D
K
E
-
V
S
M
G
Y
D
H
V
Y
T
P
V
L
A
N
V
D
L
Y
K
T
S
G
H
W
D
H
Y
Q
E
D
M
F
P
P
M
Q
L
D
E
T
-
E
S
---
M
V
L
R
P
M
N
C
P
H
H
M
M
I
Y
A
N
K
P
H
S
Y
R
E
L
P
I
R
I
A
E
L
G
T
M
H
R
Y
E
A
S
G
A
V
S
G
L
Q
R
V
R
G
M
T
L
N
D
S
H
I
F
V
R
P
D
Q
I
K
E
E
F
K
R
V
V
N
M
I
I
D
V
Y
K
D
-
F
----
G
F
E
---
D
Y
S
F
R
L
S
Y
R
D
P
----
E
D
K
E
KYF
D
D
D
D
M
W
N
K
A
E
N
M
L
K
E
A
A
D
E
L
G
L
S
Y
E
E
A
I
G
E
A
A
F
Y
G
P
K
L
D
V
Q
V
K
T
A
M
G
K
E
E
T
L
S
T
A
Q
L
D
F
L
L
P
E
R
F
D
L
T
Y
I
G
Q
D
G
E
H
H
R
P
V
V
I
H
R
G
V
V
S
T
M
E
R
F
V
A
F
L
T
E
E
T
K
G
A
F
P
T
W
L
A
P
K
Q
V
Q
I
I
P
V
N
V
---
D
---
L
H
Y
D
Y
A
R
Q
L
Q
D
E
L
K
S
--------------
Q
--------------
G
V
R
V
S
I
D
D
R
N
E
K
M
G
Y
K
I
R
E
A
Q
M
Q
K
I
P
Y
Q
I
V
V
G
D
K
E
V
E
N
N
Q
V
N
V
R
-----
Q
Y
G
S
Q
D
Q
-
E
T
V
E
K
D
E
F
I
W
N
L
V
D
E
I
R
L
22
PsiBlast_CBE
80.61
44%
-91
- C2 -
1NYQ
2
SYT_STAAW
B:
[29-625]
----------------------------
I
S
---
P
G
L
R
K
K
A
V
A
G
K
F
N
G
Q
L
V
D
L
T
K
P
L
E
T
D
G
S
I
E
I
V
T
P
G
S
E
E
A
L
E
V
L
R
H
S
T
A
H
L
M
A
H
A
I
K
R
L
Y
G
N
V
K
F
G
V
G
P
V
I
E
G
G
F
Y
Y
D
F
D
I
D
Q
N
I
S
S
D
D
F
E
Q
I
E
K
T
M
K
Q
I
V
N
E
N
M
K
I
E
R
K
V
V
S
R
D
E
A
K
E
L
F
S
N
--
D
E
Y
K
L
E
L
I
D
-
A
I
P
E
-
D
E
N
V
T
L
Y
S
Q
G
D
F
T
D
L
C
R
G
V
H
V
P
S
T
A
K
I
K
E
F
K
L
L
S
T
A
G
A
Y
W
R
G
D
S
N
N
K
M
L
Q
R
I
Y
G
T
A
F
F
D
K
K
E
L
K
A
H
L
Q
M
L
E
E
R
K
E
R
D
H
R
K
I
G
K
E
L
E
L
F
T
N
S
Q
L
V
G
A
-
G
L
P
L
W
L
P
N
G
A
T
I
R
R
E
I
E
R
Y
I
V
-
D
K
E
-
V
S
M
G
Y
D
H
V
Y
T
P
V
L
A
N
V
D
L
Y
K
T
S
G
H
W
D
H
Y
Q
E
D
M
F
P
P
M
Q
L
D
E
T
-
E
S
---
M
V
L
R
P
M
N
C
P
H
H
M
M
I
Y
A
N
K
P
H
S
Y
R
E
L
P
I
R
I
A
E
L
G
T
M
H
R
Y
E
A
S
G
A
V
S
G
L
Q
R
V
R
G
M
T
L
N
D
S
H
I
F
V
R
P
D
Q
I
K
E
E
F
K
R
V
V
N
M
I
I
D
V
Y
K
D
-
F
----
G
F
E
---
D
Y
S
F
R
L
S
Y
R
D
P
----
E
D
K
E
KYF
D
D
D
D
M
W
N
K
A
E
N
M
L
K
E
A
A
D
E
L
G
L
S
Y
E
E
A
I
G
E
A
A
F
Y
G
P
K
L
D
V
Q
V
K
T
A
M
G
K
E
E
T
L
S
T
A
Q
L
D
F
L
L
P
E
R
F
D
L
T
Y
I
G
Q
D
G
E
H
H
R
P
V
V
I
H
R
G
V
V
S
T
M
E
R
F
V
A
F
L
T
E
E
T
K
G
A
F
P
T
W
L
A
P
K
Q
V
Q
I
I
P
V
N
V
---
D
---
L
H
Y
D
Y
A
R
Q
L
Q
D
E
L
K
S
--------------
Q
--------------
G
V
R
V
S
I
D
D
R
N
E
K
M
G
Y
K
I
R
E
A
Q
M
Q
K
I
P
Y
Q
I
V
V
G
D
K
E
V
E
N
N
Q
V
N
V
R
-----
Q
Y
G
S
Q
D
Q
-
E
T
V
E
K
D
E
F
I
W
N
L
V
D
E
I
R
L
58
HHSearch
76.37
52%
-99
* C1 *
1EVL
2
SYT_ECOLI
A:
[1-392]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
-
H
M
Q
E
E
A
P
-
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
-
S
K
L
-
K
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
T
---
T
S
S
--
E
N
R
E
-
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
S
T
-
F
----
G
F
E
---
K
I
V
V
K
L
S
T
R
-
P
----
E
K
R
I
---
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
E
D
N
E
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
D
---
S
---
Q
S
-
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
--------------
G
I
R
V
K
A
D
L
R
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
-----
T
R
R
G
K
D
L
-
G
S
M
D
V
N
E
V
I
E
K
L
Q
Q
E
I
R
S
4
PsiBlast_PDB
74.30
54%
-98
- C1 -
4HWO
2
SYT_ECOLI
A:
[3-379]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
-
H
M
Q
E
E
A
P
-
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
-
S
K
L
-
K
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
T
---
T
S
-
S
-
E
N
R
E
-
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
S
T
-
F
----
G
F
E
---
K
I
V
V
K
L
S
T
R
-
P
----
E
K
R
I
---
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
E
D
N
E
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
D
---
S
---
Q
S
-
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
--------------
G
I
R
V
K
A
D
L
R
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
RRGK
D
L
G
S
M
D
V
-
N
E
V
I
E
K
L
Q
Q
E
I
R
S
R
S
L
K
Q
9
PsiBlast_PDB
74.28
54%
-98
- C1 -
1EVL
2
SYT_ECOLI
A:
[1-377]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
-
H
M
Q
E
E
A
P
-
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
-
S
K
L
-
K
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
T
---
T
S
-
S
-
E
N
R
E
-
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
S
T
-
F
----
G
F
E
---
K
I
V
V
K
L
S
T
R
-
P
----
E
K
R
I
---
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
E
D
N
E
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
D
---
S
---
Q
S
-
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
--------------
G
I
R
V
K
A
D
L
R
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
RRGK
D
L
G
S
M
D
V
-
N
E
V
I
E
K
L
Q
Q
E
I
R
S
R
S
L
K
Q
38
PsiBlast_CBE
74.07
54%
-96
- C1 -
1EVK
2
SYT_ECOLI
B:
[1-377]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
-
H
M
Q
E
E
A
P
-
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
-
S
K
L
-
K
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
T
---
T
S
-
S
-
E
N
R
E
-
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
S
T
-
F
----
G
F
E
---
K
I
V
V
K
L
S
T
R
-
P
----
E
K
R
I
---
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
E
D
N
E
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
D
---
S
---
Q
S
-
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
--------------
G
I
R
V
K
A
D
L
R
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
TRRGK
D
L
G
S
M
D
V
-
N
E
V
I
E
K
L
Q
Q
E
I
R
S
R
S
L
K
Q
10
PsiBlast_PDB
73.96
54%
-97
- C1 -
1FYF
2
SYT_ECOLI
A:
[1-377]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
-
H
M
Q
E
E
A
P
-
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
-
S
K
L
-
K
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
T
---
T
S
-
S
-
E
N
R
E
-
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
S
T
-
F
----
G
F
E
---
K
I
V
V
K
L
S
T
R
-
P
----
E
K
R
I
---
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
E
D
N
E
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
D
---
S
---
Q
S
-
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
--------------
G
I
R
V
K
A
D
L
R
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
RRGK
D
L
G
S
M
D
V
-
N
E
V
I
E
K
L
Q
Q
E
I
R
S
R
S
L
K
Q
8
PsiBlast_PDB
73.86
54%
-95
- C1 -
1EVK
1
SYT_ECOLI
A:
[1-377]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
-
H
M
Q
E
E
A
P
-
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
-
S
K
L
-
K
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
T
---
T
S
-
S
-
E
N
R
E
-
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
S
T
-
F
----
G
F
E
---
K
I
V
V
K
L
S
T
R
-
P
----
E
K
R
I
---
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
E
D
N
E
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
D
---
S
---
Q
S
-
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
--------------
G
I
R
V
K
A
D
L
R
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
RRGK
D
L
G
S
M
D
V
-
N
E
V
I
E
K
L
Q
Q
E
I
R
S
R
S
L
K
Q
39
PsiBlast_CBE
73.83
54%
-96
- C1 -
4P3P
7
SYT_ECOLI
B:
[2-378]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
-
H
M
Q
E
E
A
P
-
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
-
S
K
L
-
K
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
T
---
T
S
-
S
-
E
N
R
E
-
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
S
T
-
F
----
G
F
E
---
K
I
V
V
K
L
S
T
R
-
P
----
E
K
R
I
---
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
E
D
N
E
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
D
---
S
---
Q
S
-
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
--------------
G
I
R
V
K
A
D
L
R
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
TRRGK
D
L
G
S
M
D
V
-
N
E
V
I
E
K
L
Q
Q
E
I
R
S
R
S
L
K
Q
7
PsiBlast_PDB
73.77
54%
-99
- C1 -
4HWS
2
SYT_ECOLI
A:
[3-379]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
-
H
M
Q
E
E
A
P
-
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
-
S
K
L
-
K
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
T
---
T
S
-
S
-
E
N
R
E
-
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
S
T
-
F
----
G
F
E
---
K
I
V
V
K
L
S
T
R
-
P
----
E
K
R
I
---
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
E
D
N
E
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
D
---
S
---
Q
S
-
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
--------------
G
I
R
V
K
A
D
L
R
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
RRGK
D
L
G
S
M
D
V
-
N
E
V
I
E
K
L
Q
Q
E
I
R
S
R
S
L
K
Q
40
PsiBlast_CBE
73.69
54%
-94
- C1 -
4P3O
7
SYT_ECOLI
B:
[2-378]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
-
H
M
Q
E
E
A
P
-
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
-
S
K
L
-
K
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
T
---
T
S
-
S
-
E
N
R
E
-
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
S
T
-
F
----
G
F
E
---
K
I
V
V
K
L
S
T
R
-
P
----
E
K
R
I
---
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
E
D
N
E
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
D
---
S
---
Q
S
-
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
--------------
G
I
R
V
K
A
D
L
R
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
TRRGK
D
L
G
S
M
D
V
-
N
E
V
I
E
K
L
Q
Q
E
I
R
S
R
S
L
K
Q
35
PsiBlast_CBE
73.61
54%
-94
- C1 -
1EVL
2
SYT_ECOLI
D:
[1-377]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
-
H
M
Q
E
E
A
P
-
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
-
S
K
L
-
K
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
T
---
T
S
-
S
-
E
N
R
E
-
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
S
T
-
F
----
G
F
E
---
K
I
V
V
K
L
S
T
R
-
P
----
E
K
R
I
---
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
E
D
N
E
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
D
---
S
---
Q
S
-
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
--------------
G
I
R
V
K
A
D
L
R
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
TRRGK
D
L
G
S
M
D
V
-
N
E
V
I
E
K
L
Q
Q
E
I
R
S
R
S
L
K
Q
37
PsiBlast_CBE
73.55
54%
-97
- C1 -
1EVL
2
SYT_ECOLI
B:
[1-377]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
-
H
M
Q
E
E
A
P
-
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
-
S
K
L
-
K
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
T
---
T
S
-
S
-
E
N
R
E
-
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
S
T
-
F
----
G
F
E
---
K
I
V
V
K
L
S
T
R
-
P
----
E
K
R
I
---
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
E
D
N
E
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
D
---
S
---
Q
S
-
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
--------------
G
I
R
V
K
A
D
L
R
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
TRRGK
D
L
G
S
M
D
V
-
N
E
V
I
E
K
L
Q
Q
E
I
R
S
R
S
L
K
Q
26
PsiBlast_CBE
73.51
54%
-100
- C1 -
4HWO
2
SYT_ECOLI
B:
[3-379]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
-
H
M
Q
E
E
A
P
-
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
-
S
K
L
-
K
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
T
---
T
S
-
S
-
E
N
R
E
-
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
S
T
-
F
----
G
F
E
---
K
I
V
V
K
L
S
T
R
-
P
----
E
K
R
I
---
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
E
D
N
E
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
D
---
S
---
Q
S
-
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
--------------
G
I
R
V
K
A
D
L
R
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
TRRGK
D
L
G
S
M
D
V
-
N
E
V
I
E
K
L
Q
Q
E
I
R
S
R
S
L
K
Q
23
PsiBlast_CBE
73.39
54%
-99
- C1 -
4HWS
2
SYT_ECOLI
B:
[3-379]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
-
H
M
Q
E
E
A
P
-
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
-
S
K
L
-
K
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
T
---
T
S
-
S
-
E
N
R
E
-
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
S
T
-
F
----
G
F
E
---
K
I
V
V
K
L
S
T
R
-
P
----
E
K
R
I
---
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
E
D
N
E
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
D
---
S
---
Q
S
-
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
--------------
G
I
R
V
K
A
D
L
R
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
TRRGK
D
L
G
S
M
D
V
-
N
E
V
I
E
K
L
Q
Q
E
I
R
S
R
S
L
K
Q
13
PsiBlast_PDB
73.36
54%
-96
- C1 -
4P3P
6
SYT_ECOLI
A:
[2-378]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
-
H
M
Q
E
E
A
P
-
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
-
S
K
L
-
K
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
T
---
T
S
-
S
-
E
N
R
E
-
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
S
T
-
F
----
G
F
E
---
K
I
V
V
K
L
S
T
R
-
P
----
E
K
R
I
---
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
E
D
N
E
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
D
---
S
---
Q
S
-
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
--------------
G
I
R
V
K
A
D
L
R
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
RRGK
D
L
G
S
M
D
V
-
N
E
V
I
E
K
L
Q
Q
E
I
R
S
R
S
L
K
Q
34
PsiBlast_CBE
73.29
54%
-98
- C1 -
1FYF
2
SYT_ECOLI
B:
[1-377]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
-
H
M
Q
E
E
A
P
-
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
-
S
K
L
-
K
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
T
---
T
S
-
S
-
E
N
R
E
-
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
S
T
-
F
----
G
F
E
---
K
I
V
V
K
L
S
T
R
-
P
----
E
K
R
I
---
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
E
D
N
E
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
D
---
S
---
Q
S
-
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
--------------
G
I
R
V
K
A
D
L
R
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
TRRGK
D
L
G
S
M
D
V
-
N
E
V
I
E
K
L
Q
Q
E
I
R
S
R
S
L
K
Q
24
PsiBlast_CBE
73.23
54%
-98
- C1 -
4HWR
2
SYT_ECOLI
B:
[3-379]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
-
H
M
Q
E
E
A
P
-
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
-
S
K
L
-
K
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
T
---
T
S
-
S
-
E
N
R
E
-
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
S
T
-
F
----
G
F
E
---
K
I
V
V
K
L
S
T
R
-
P
----
E
K
R
I
---
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
E
D
N
E
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
D
---
S
---
Q
S
-
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
--------------
G
I
R
V
K
A
D
L
R
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
RRGK
D
L
G
S
M
D
V
-
N
E
V
I
E
K
L
Q
Q
E
I
R
S
R
S
L
K
Q
5
PsiBlast_PDB
73.16
54%
-98
- C1 -
4HWP
2
SYT_ECOLI
A:
[3-379]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
-
H
M
Q
E
E
A
P
-
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
-
S
K
L
-
K
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
T
---
T
S
-
S
-
E
N
R
E
-
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
S
T
-
F
----
G
F
E
---
K
I
V
V
K
L
S
T
R
-
P
----
E
K
R
I
---
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
E
D
N
E
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
D
---
S
---
Q
S
-
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
--------------
G
I
R
V
K
A
D
L
R
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
RRGK
D
L
G
S
M
D
V
-
N
E
V
I
E
K
L
Q
Q
E
I
R
S
R
S
L
K
Q
25
PsiBlast_CBE
72.95
54%
-97
- C1 -
4HWP
2
SYT_ECOLI
B:
[3-379]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
-
H
M
Q
E
E
A
P
-
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
-
S
K
L
-
K
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
T
---
T
S
-
S
-
E
N
R
E
-
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
S
T
-
F
----
G
F
E
---
K
I
V
V
K
L
S
T
R
-
P
----
E
K
R
I
---
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
E
D
N
E
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
D
---
S
---
Q
S
-
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
--------------
G
I
R
V
K
A
D
L
R
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
TRRGK
D
L
G
S
M
D
V
-
N
E
V
I
E
K
L
Q
Q
E
I
R
S
R
S
L
K
Q
6
PsiBlast_PDB
72.67
54%
-99
- C1 -
4HWR
2
SYT_ECOLI
A:
[3-379]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
-
H
M
Q
E
E
A
P
-
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
-
S
K
L
-
K
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
T
---
T
S
-
S
-
E
N
R
E
-
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
S
T
-
F
----
G
F
E
---
K
I
V
V
K
L
S
T
R
-
P
----
E
K
R
I
---
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
E
D
N
E
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
D
---
S
---
Q
S
-
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
--------------
G
I
R
V
K
A
D
L
R
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
RRGK
D
L
G
S
M
D
V
-
N
E
V
I
E
K
L
Q
Q
E
I
R
S
R
S
L
K
Q
12
PsiBlast_PDB
72.41
54%
-96
- C1 -
4P3O
6
SYT_ECOLI
A:
[2-378]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
-
H
M
Q
E
E
A
P
-
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
-
S
K
L
-
K
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
T
---
T
S
-
S
-
E
N
R
E
-
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
S
T
-
F
----
G
F
E
---
K
I
V
V
K
L
S
T
R
-
P
----
E
K
R
I
---
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
E
D
N
E
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
D
---
S
---
Q
S
-
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
--------------
G
I
R
V
K
A
D
L
R
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
RRGK
D
L
G
S
M
D
V
-
N
E
V
I
E
K
L
Q
Q
E
I
R
S
R
S
L
K
Q
57
HHSearch
69.67
36%
-89
- C1 -
3UH0
3
SYTM_YEAST
A:
[33-457]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
T
M
T
S
M
V
S
Q
R
Q
D
L
F
-
M
T
D
P
L
S
P
-
G
S
M
F
F
L
P
N
G
A
K
I
F
N
K
L
I
E
F
M
K
-
L
Q
Q
K
F
K
F
G
F
N
E
V
V
T
P
L
I
Y
K
K
T
L
W
E
K
S
G
H
W
E
N
Y
A
D
D
M
F
K
---
V
E
T
-----
E
-
Y
G
L
K
P
M
N
C
P
G
H
C
L
I
F
G
K
K
D
R
S
Y
N
E
L
P
L
R
F
S
D
F
S
P
L
H
R
N
E
A
S
G
A
L
S
G
L
T
R
L
R
K
F
H
Q
D
D
G
H
I
F
C
T
P
S
Q
V
K
S
E
I
F
N
S
L
K
L
I
D
I
V
Y
N
K
I
F
----
P
F
V
AES
N
Y
F
I
N
F
S
T
R
-
P
----
D
H
F
I
---
G
D
L
K
V
W
N
H
A
E
Q
V
L
K
E
I
L
E
E
S
G
K
P
W
K
L
N
P
G
D
G
A
F
Y
G
P
K
L
D
I
M
V
T
D
H
L
R
K
T
H
Q
V
A
T
I
Q
L
D
F
Q
L
P
E
R
F
D
L
K
F
K
D
Q
D
N
S
Y
K
R
P
I
M
I
H
R
A
T
F
G
S
I
E
R
F
M
A
L
L
I
D
S
N
E
G
R
W
P
F
W
L
N
P
Y
Q
A
V
I
I
P
V
N
T
---
K
N
V
Q
Q
L
-
D
M
C
T
A
L
Q
K
K
L
R
N
ELEADDMEPVPLN
D
W
--------------
H
F
N
V
D
L
D
I
R
N
E
P
V
G
Y
R
I
K
S
A
I
L
K
N
Y
S
Y
L
I
I
V
G
D
E
E
V
Q
L
Q
K
Y
N
I
R
-----
E
R
D
N
R
K
S
F
E
K
L
T
M
S
Q
I
W
E
K
F
I
E
L
E
K
N
18
PsiBlast_PDB
64.32
35%
-83
- C1 -
3UH0
3
SYTM_YEAST
A:
[40-442]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
Q
R
Q
D
L
F
-
M
T
D
P
L
S
P
-
G
S
M
F
F
L
P
N
G
A
K
I
F
N
K
L
I
E
F
M
K
L
Q
Q
K
-
F
K
F
G
F
N
E
V
V
T
P
L
I
Y
K
K
T
L
W
E
K
S
G
H
W
E
N
Y
A
D
D
M
F
K
---
V
E
T
------E
Y
G
L
K
P
M
N
C
P
G
H
C
L
I
F
G
K
K
D
R
S
Y
N
E
L
P
L
R
F
S
D
F
S
P
L
H
R
N
E
A
S
G
A
L
S
G
L
T
R
L
R
K
F
H
Q
D
D
G
H
I
F
C
T
P
S
Q
V
K
S
E
I
F
N
S
L
K
L
I
D
I
V
Y
N
K
-
I
FPFV
A
E
S
---
N
Y
F
I
N
F
S
T
R
-
P
----
D
H
F
I
---
G
D
L
K
V
W
N
H
A
E
Q
V
L
K
E
I
L
E
E
S
G
K
P
W
K
L
N
P
G
D
G
A
F
Y
G
P
K
L
D
I
M
V
T
D
H
L
R
K
T
H
Q
V
A
T
I
Q
L
D
F
Q
L
P
E
R
F
D
L
K
F
K
D
Q
D
N
S
Y
K
R
P
I
M
I
H
R
A
T
F
G
S
I
E
R
F
M
A
L
L
I
D
S
N
E
G
R
W
P
F
W
L
N
P
Y
Q
A
V
I
I
P
V
N
T
KN
V
Q
---
Q
L
-
D
M
C
T
A
L
Q
K
K
L
R
N
--------------
E
LEADDMEPVPLN
D
W
H
F
N
V
D
L
D
I
R
N
E
P
V
G
Y
R
I
K
S
A
I
L
K
N
Y
S
Y
L
I
I
V
G
D
E
E
V
Q
L
Q
K
Y
N
I
R
---------
E
R
D
-
N
R
K
S
F
E
K
L
T
M
S
Q
I
W
E
K
F
I