@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0527: (2015-12-02 )
MKKMEACYSFDDILLLPAYSNILPCNADTKTYLTNSIELNIPLISSAMDTVTESDFAITIAQHGGIGCIHKNLSVDEQVSEVRRVKKYENWIVYNPITISPDKTVAEAISLMKKHDYSGIPVVDQRKLVGVLTNRDIRFIEDQNMSIKVSEVMTKEKLVTIREQEVDSASAMKLLHENRIEKLLVIDENFCCIGLITVKDIEKYNRYPNSCKDSKGRLRVAAAVGTGKKDGIERCEALIGEEIDVIIVDTAHGHSENVIDTIKEIKTMYPNTQLVGGNIATKEAAEALIDAGVDAVKVGIGPGSICTTRVVTGVGVPQFSAIQSVAETCKARKVRLIADGGIKYSGDIAKAIAAGADSVMIGSIFAGTDESPGEIIMYKGRAYKGYRGMGSISAMKQGSASRYFQDKDSKLKLVPQGVEGRVPFKGPASGVIHQLIGGLQAAMGYTGNRNIEEMKKNCRFVIITASGLRESHAHDIIITQEAPNYAYQVFNLLTDSDA
Atome Classification :
(41 SA)
.........10........20..--......30...-------.....40........50........60........70........80....--....90........100.......110.......120.---.---.---....130.......140.......150..-.....160.......170.......180.......190.......200.......210--.......220....--...230.......240.......250.......260.......270........280.......290.......300.......310.......320.......330-----........340.......350.......360.......370.......380.......390...---....400-------......-..410........420.......430.......440.......450....-----...460.......470.......480.......490......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MK
K
M
E
A
CYSFD
D
I
L
L
LPAYSNIL--PCNADT
K
T
Y
L
T-------
N
S
I
E
L
NIP
L
I
S
S
A
M
D
TVTES
D
F
A
I
T
I
AQHG
G
I
G
C
I
HKNLS
V
D
E
Q
V
S
E
V
R
R
V
--
K
K
YE
N
W
I
V
YN
P
I
TISP
D
K
T
V
A
E
A
I
S
L
M
K
KHDYSGIPVV---
D
---
Q
---
R
K
L
V
G
V
LTNR
D
I
R
F
I
EDQN
M
S
I
K
V
S
E
V
M
T
-
K
E
K
L
V
T
I
R
E
QEV
D
S
A
S
A
M
K
L
L
H
E
NRI
E
K
L
L
V
IDEN
F
C
C
I
G
L
I
T
V
K
D
I
E
K
Y
NRYPNSCK--DSKG
R
L
R
V
A
A
A
VGT--GK
K
D
G
I
E
R
C
E
A
L
IGEEI
D
V
I
I
V
DTAHGHS
E
N
V
I
D
T
I
K
E
I
K
T
MYP-N
T
Q
L
VGGNI
A
T
K
E
A
A
E
A
L
I
D
AGV
D
A
V
K
VGIGPGS
I
C
T
T
R
V
V
TGVGV
P
Q
F
S
A
I
Q
S
V
A
E
T
C
KA------
R
K
V
R
L
I
ADGG
I
K
YS
G
D
I
A
K
A
I
AAGAD
S
V
M
I
G
S
I
FAGTDESPG
E
I
I
M
YKGRAYKGYRGMG
S
I
S
A
M
---KQGSAS--------RYFQDK-DS
K
L
-
K
LVPQGVEGRVPFKG
P
A
S
G
V
I
H
Q
L
I
G
G
L
Q
A
A
MGYTGNR
N
I
E
E
M
KK-----NC
R
F
V
I
I
TASGLRESHAH
D
I
I
I
TQEAP
N
Y
A
Y
Q
V
F
N
L
LTDSDA
106
HHSearch
96.64
55%
-91
- C3 -
1ZFJ
1
IMDH_STRPY
A:
[7-490]
--
F
L
K
K
G
Y
T
F
D
D
V
L
L
I
P
A
E
S
H
V
L
--
P
N
E
V
D
L
K
T
K
L
A
-------
D
N
L
T
L
N
I
P
I
I
T
A
A
M
D
T
V
T
G
S
K
M
A
I
A
I
A
R
A
G
G
L
G
V
I
H
K
N
M
S
I
T
E
Q
A
E
E
V
R
K
V
--
K
R
S
E
N
G
V
I
I
D
P
F
F
L
T
P
E
H
K
V
S
E
A
E
E
L
M
Q
R
Y
R
I
S
G
V
P
I
V
---
E
TLA
N
---
R
K
L
V
G
I
I
T
N
R
D
M
R
F
I
S
D
Y
--
N
A
P
I
S
E
H
M
T
-
S
E
H
L
V
T
A
A
V
-
G
T
D
L
E
T
A
E
R
I
L
H
E
H
R
I
E
K
L
P
L
V
D
N
S
G
R
L
S
G
L
I
T
I
K
D
I
E
K
V
I
E
F
P
H
A
A
K
--
D
E
F
G
R
L
L
V
A
A
A
V
G
V
--
T
S
-
D
T
F
E
R
A
E
A
L
F
E
A
G
A
D
A
I
V
I
D
T
A
H
G
H
S
A
G
V
L
R
K
I
A
E
I
R
A
H
F
P
-
N
R
T
L
I
A
G
N
I
A
T
A
E
G
A
R
A
L
Y
D
A
G
V
D
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
V
T
A
I
Y
D
A
A
A
V
A
R
E
------
Y
G
K
T
I
I
A
D
G
G
I
K
Y
S
G
D
I
V
K
A
L
A
A
G
G
N
A
V
M
L
G
S
M
F
A
G
T
D
E
A
P
G
E
T
E
I
Y
Q
G
R
K
Y
K
T
Y
R
G
M
G
S
I
A
A
M
---
K
K
----------------------
N
-
K
L
V
P
E
G
I
E
G
R
V
A
Y
K
G
A
A
S
D
I
V
F
Q
M
L
G
G
I
R
S
G
M
G
Y
V
G
A
G
D
I
Q
E
L
H
E
-----
N
A
Q
F
V
E
M
S
G
A
G
L
I
E
S
H
P
H
D
V
Q
I
T
N
E
A
P
N
Y
S
V
-----------
9
PsiBlast_PDB
95.57
48%
-100
- C3 -
4FXS
3
?
A:
[4-486]
L
R
I
A
K
E
A
L
T
F
D
D
V
L
L
V
P
A
H
S
T
V
L
--
P
N
T
A
D
L
R
T
R
L
T
-------
K
N
I
A
L
N
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
N
M
S
I
E
Q
Q
A
A
Q
V
H
Q
V
--
K
I
F
E
A
--
V
T
H
P
V
T
V
R
P
E
Q
T
I
A
D
V
M
E
L
T
H
Y
H
G
F
A
G
F
P
V
V
T
--
E
---
N
---
N
E
L
V
G
I
I
T
G
R
D
V
R
F
V
T
D
--
L
T
K
S
V
A
A
V
M
T
P
K
E
R
L
A
T
V
K
E
G
-----
E
V
Q
E
K
M
H
---
V
E
K
I
L
V
V
N
D
E
F
Q
L
K
G
M
I
T
A
K
-----
E
S
K
P
N
A
C
K
--
D
E
Q
G
R
L
R
V
G
A
A
V
G
A
--
A
P
G
N
E
-
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
---
S
K
G
S
S
D
--------
R
Y
F
Q
T
----
A
D
-
K
L
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
-------------
8
PsiBlast_PDB
95.53
52%
-91
- C3 -
1ZFJ
1
IMDH_STRPY
A:
[6-490]
-
K
F
L
K
K
G
Y
T
F
D
D
V
L
L
I
P
A
E
S
H
V
L
--
P
N
E
V
D
L
K
T
K
L
A
-------
D
N
L
T
L
N
I
P
I
I
T
A
A
M
D
T
V
T
G
S
K
M
A
I
A
I
A
R
A
G
G
L
G
V
I
H
K
N
M
S
I
T
E
Q
A
E
E
V
R
K
V
--
K
R
S
E
N
G
V
I
I
D
P
F
F
L
T
P
E
H
K
V
S
E
A
E
E
L
M
Q
R
Y
R
I
S
G
V
P
I
V
---
E
TLA
N
---
R
K
L
V
G
I
I
T
N
R
D
M
R
F
I
S
D
Y
N
A
P
I
--
S
E
H
M
T
-
S
E
H
L
V
T
A
-
A
V
G
T
D
L
E
T
A
E
R
I
L
H
E
H
R
I
E
K
L
P
L
V
D
N
S
G
R
L
S
G
L
I
T
I
K
D
I
E
K
V
I
E
F
P
H
A
A
K
--
D
E
F
G
R
L
L
V
A
A
A
V
G
V
---
T
S
D
T
F
E
R
A
E
A
L
F
E
A
G
A
D
A
I
V
I
D
T
A
H
G
H
S
A
G
V
L
R
K
I
A
E
I
R
A
H
F
P
-
N
R
T
L
I
A
G
N
I
A
T
A
E
G
A
R
A
L
Y
D
A
G
V
D
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
V
T
A
I
Y
D
A
A
A
V
A
R
E
------
Y
G
K
T
I
I
A
D
G
G
I
K
Y
S
G
D
I
V
K
A
L
A
A
G
G
N
A
V
M
L
G
S
M
F
A
G
T
D
E
A
P
G
E
T
E
I
Y
Q
G
R
K
Y
K
T
Y
R
G
M
G
S
I
A
A
M
---
K
K
----------------------
N
-
K
L
V
P
E
G
I
E
G
R
V
A
Y
K
G
A
A
S
D
I
V
F
Q
M
L
G
G
I
R
S
G
M
G
Y
V
G
A
G
D
I
Q
E
L
H
E
-----
N
A
Q
F
V
E
M
S
G
A
G
L
I
E
S
H
P
H
D
V
Q
I
T
N
E
A
P
N
Y
S
V
-----------
5
PsiBlast_PDB
95.46
55%
-98
- C3 -
4DQW
7
?
A:
[26-486]
----
Q
E
A
L
T
F
D
D
V
L
L
I
P
G
Y
S
E
V
L
--
P
K
D
V
S
L
K
T
R
L
T
-------
R
G
I
E
L
N
I
P
L
V
S
A
A
M
D
T
V
T
E
A
R
L
A
I
A
M
A
Q
E
G
G
I
G
I
I
H
K
N
M
G
I
E
Q
Q
A
A
E
V
R
K
V
--
K
K
H
E
T
A
I
V
R
D
P
V
T
V
T
P
S
T
K
I
I
E
L
L
Q
M
A
R
E
Y
G
F
S
G
F
P
V
V
---
E
---
Q
---
G
E
L
V
G
I
V
T
G
R
D
L
R
V
--
K
P
N
A
G
D
T
V
A
A
I
M
T
P
K
D
K
L
V
T
A
R
E
G
T
P
L
E
E
M
K
A
K
L
-
Y
E
N
R
I
E
K
M
L
V
V
D
E
N
F
Y
L
R
G
L
V
T
F
R
D
I
E
K
A
K
T
Y
P
L
A
S
K
--
D
E
Q
G
R
L
R
V
G
A
A
V
G
T
--
G
A
D
T
G
-
E
R
V
A
A
L
V
A
A
G
V
D
V
V
V
V
D
T
A
H
G
H
S
K
G
V
I
E
R
V
R
W
V
K
Q
T
F
P
-
D
V
Q
V
I
G
G
N
I
A
T
A
E
A
A
K
A
L
A
E
A
G
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
S
A
I
A
N
V
A
A
A
L
E
G
------
T
G
V
P
L
I
A
D
G
G
I
R
F
S
G
D
L
A
K
A
M
V
A
G
A
Y
C
V
M
M
G
S
M
F
A
G
T
E
E
A
P
G
E
-------------------------------------------------------------
P
Y
K
G
A
L
S
A
I
V
H
Q
L
M
G
G
L
R
A
A
M
G
Y
T
G
S
A
D
I
Q
Q
M
R
T
-----
Q
P
Q
F
V
R
I
T
G
---------------------------------
2
PsiBlast_PDB
94.18
53%
-88
- C3 -
3TSB
2
?
A:
[36-510]
--------
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
--
P
R
E
V
S
V
K
T
V
L
S
-------
E
S
L
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
M
S
I
E
Q
Q
A
E
Q
V
D
K
V
--
K
R
S
E
S
G
V
I
S
D
P
F
F
L
T
P
E
H
Q
V
Y
D
A
E
H
L
M
G
K
Y
R
I
S
G
V
P
V
V
NNL
D
---
E
---
R
K
L
V
G
I
I
T
N
R
D
M
R
F
I
Q
D
--
Y
S
I
K
I
S
D
V
M
T
-
K
E
Q
L
I
T
A
P
V
G
T
T
L
S
-
E
A
E
K
I
L
Q
K
Y
K
I
E
K
L
P
L
V
D
N
N
G
V
L
Q
G
L
I
T
I
K
D
I
E
K
V
I
E
F
P
N
S
A
K
--
D
K
Q
G
R
L
L
V
G
A
A
V
G
V
---
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
---
E
K
G
S
K
D
--------
R
Y
F
Q
E
G
-
N
K
---
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
Q
F
I
R
M
S
G
A
G
L
L
E
S
H
P
H
H
V
Q
I
T
K
E
A
P
N
Y
S
------------
105
HHSearch
93.60
53%
-101
- C3 -
3USB
4
?
A:
[30-493]
--
F
V
K
E
G
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
--
P
R
E
V
S
V
K
T
V
L
S
-------
E
S
L
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
M
S
I
E
Q
Q
A
E
Q
V
D
K
V
--
K
R
S
E
S
G
V
I
S
D
P
F
F
L
T
P
E
H
Q
V
Y
D
A
E
H
L
M
G
K
Y
R
I
S
G
V
P
V
V
---
N
---
N
LDE
R
K
L
V
G
I
I
T
N
R
D
M
R
F
I
Q
D
Y
--
S
I
K
I
S
D
V
M
T
-
K
E
Q
L
I
T
A
P
V
-
G
T
T
L
S
E
A
E
K
I
L
Q
K
Y
K
I
E
K
L
P
L
V
D
N
N
G
V
L
Q
G
L
I
T
I
K
D
I
E
K
V
I
E
F
P
N
S
A
K
--
D
K
Q
G
R
L
L
V
G
A
A
V
G
V
--
T
A
-
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
-------------------------------------------------
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
Q
F
I
R
M
S
G
A
G
L
L
-----------------------------
6
PsiBlast_PDB
93.02
55%
-93
- C3 -
4AVF
-
?
A:
[6-467]
----
Q
E
A
L
T
F
D
D
V
L
L
I
P
G
Y
S
E
V
L
--
P
K
D
V
S
L
K
T
R
L
T
-------
R
G
I
E
L
N
I
P
L
V
S
A
A
M
D
T
V
T
E
A
R
L
A
I
A
M
A
Q
E
G
G
I
G
I
I
H
K
N
M
G
I
E
Q
Q
A
A
E
V
R
K
V
--
K
K
H
E
T
------------------------------------------------------------------------------------------------------------------------------
Y
P
L
A
S
K
--
D
E
Q
G
R
L
R
V
G
A
A
V
G
T
--
G
A
D
T
G
-
E
R
V
A
A
L
V
A
A
G
V
D
V
V
V
V
D
T
A
H
G
H
S
K
G
V
I
E
R
V
R
W
V
K
Q
T
F
P
-
D
V
Q
V
I
G
G
N
I
A
T
A
E
A
A
K
A
L
A
E
A
G
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
S
A
I
A
N
V
A
A
A
L
E
G
------
T
G
V
P
L
I
A
D
G
G
I
R
F
S
G
D
L
A
K
A
M
V
A
G
A
Y
C
V
M
M
G
S
M
F
A
G
T
E
E
A
P
G
E
I
E
L
F
Q
G
R
S
Y
K
S
-------------------------------------------------
V
P
Y
K
G
A
L
S
A
I
V
H
Q
L
M
G
G
L
R
A
A
M
G
Y
T
G
S
A
D
I
Q
Q
M
R
T
-----
Q
P
Q
F
V
R
I
T
G
A
--------------------------------
3
PsiBlast_PDB
92.58
53%
-95
- C3 -
3TSD
1
?
A:
[36-497]
--------
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
--
P
R
E
V
S
V
K
T
V
L
S
-------
E
S
L
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
M
S
I
E
Q
Q
A
E
Q
V
D
K
V
--
K
R
S
E
S
G
V
I
S
D
P
F
F
L
T
P
E
H
Q
V
Y
D
A
E
H
L
M
G
K
Y
R
I
S
G
V
P
V
V
NNL
D
---
E
---
R
K
L
V
G
I
I
T
N
R
D
M
R
F
I
Q
D
--
Y
S
I
K
I
S
D
V
M
--
K
E
Q
L
I
T
A
P
V
G
T
T
L
S
-
E
A
E
K
I
L
Q
K
Y
K
I
E
K
L
P
L
V
D
N
N
G
V
L
Q
G
L
I
T
I
K
D
I
E
K
V
I
E
F
P
N
S
A
K
--
D
K
Q
G
R
L
L
V
G
A
A
V
G
V
---
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
------
R
Q
F
K
V
Y
R
G
-------------------------------------------
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
Q
F
I
R
M
S
G
A
G
L
L
E
S
H
P
-------------------------
21
PsiBlast_CBE
92.45
55%
-100
- C3 -
4DQW
5
?
B:
[26-486]
----
Q
E
A
L
T
F
D
D
V
L
L
I
P
G
Y
S
E
V
L
--
P
K
D
V
S
L
K
T
R
L
T
-------
R
G
I
E
L
N
I
P
L
V
S
A
A
M
D
T
V
T
E
A
R
L
A
I
A
M
A
Q
E
G
G
I
G
I
I
H
K
N
M
G
I
E
Q
Q
A
A
E
V
R
K
V
--
K
K
H
E
T
A
I
V
R
D
P
V
T
V
T
P
S
T
K
I
I
E
L
L
Q
M
A
R
E
Y
G
F
S
G
F
P
V
V
---
E
---
Q
---
G
E
L
V
G
I
V
T
G
R
D
L
R
V
-------
D
T
V
A
A
I
M
T
P
K
D
K
L
V
T
A
R
E
G
T
P
L
E
E
M
K
A
K
L
-
Y
E
N
R
I
E
K
M
L
V
V
D
E
N
F
Y
L
R
G
L
V
T
F
R
D
I
E
K
A
K
T
Y
P
L
A
S
K
--
D
E
Q
G
R
L
R
V
G
A
A
V
G
T
--
G
A
D
T
G
-
E
R
V
A
A
L
V
A
A
G
V
D
V
V
V
V
D
T
A
H
G
H
S
K
G
V
I
E
R
V
R
W
V
K
Q
T
F
P
-
D
V
Q
V
I
G
G
N
I
A
T
A
E
A
A
K
A
L
A
E
A
G
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
S
A
I
A
N
V
A
A
A
L
E
G
------
T
G
V
P
L
I
A
D
G
G
I
R
F
S
G
D
L
A
K
A
M
V
A
G
A
Y
C
V
M
M
G
S
M
F
A
G
T
E
E
A
P
-------------------------------------------------------------------
A
L
S
A
I
V
H
Q
L
M
G
G
L
R
A
A
M
G
Y
T
G
S
A
D
I
Q
Q
M
R
T
-----
Q
P
Q
F
V
R
I
T
G
---------------------------------
7
PsiBlast_PDB
91.81
55%
-96
- C3 -
5AHN
2
?
A:
[6-467]
----
Q
E
A
L
T
F
D
D
V
L
L
I
P
G
Y
S
E
V
L
--
P
K
D
V
S
L
K
T
R
L
T
-------
R
G
I
E
L
N
I
P
L
V
S
A
A
M
D
T
V
T
E
A
R
L
A
I
A
M
A
Q
E
G
G
I
G
I
I
H
K
N
M
G
I
E
Q
Q
A
A
E
V
R
K
V
--
K
K
H
-------------------------------------------------------------------------------------------------------------------------------
T
Y
P
L
A
S
K
--
D
E
Q
G
R
L
R
V
G
A
A
V
G
T
--
G
A
D
T
G
-
E
R
V
A
A
L
V
A
A
G
V
D
V
V
V
V
D
T
A
H
G
H
S
K
G
V
I
E
R
V
R
W
V
K
Q
T
F
P
-
D
V
Q
V
I
G
G
N
I
A
T
A
E
A
A
K
A
L
A
E
A
G
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
S
A
I
A
N
V
A
A
A
L
E
G
------
T
G
V
P
L
I
A
D
G
G
I
R
F
S
G
D
L
A
K
A
M
V
A
G
A
Y
C
V
M
M
G
S
M
F
A
G
T
E
E
A
P
G
-----------------------------------------------------------------
G
A
L
S
A
I
V
H
Q
L
M
G
G
L
R
A
A
M
G
Y
T
G
S
A
D
I
Q
Q
M
R
T
-----
Q
P
Q
F
V
R
I
T
G
A
--------------------------------
10
PsiBlast_PDB
91.77
51%
-99
- C3 -
3USB
4
?
A:
[36-493]
--------
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
--
P
R
E
V
S
V
K
T
V
L
S
-------
E
S
L
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
M
S
I
E
Q
Q
A
E
Q
V
D
K
V
--
K
R
S
E
S
G
V
I
S
D
P
F
F
L
T
P
E
H
Q
V
Y
D
A
E
H
L
M
G
K
Y
R
I
S
G
V
P
V
V
NNL
D
---
E
---
R
K
L
V
G
I
I
T
N
R
D
M
R
F
I
Q
D
--
Y
S
I
K
I
S
D
V
M
T
-
K
E
Q
L
I
T
A
P
V
G
T
T
L
S
-
E
A
E
K
I
L
Q
K
Y
K
I
E
K
L
P
L
V
D
N
N
G
V
L
Q
G
L
I
T
I
K
D
I
E
K
V
I
E
F
P
N
S
A
K
--
D
K
Q
G
R
L
L
V
G
A
A
V
G
V
---
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
-------------------------------------------------
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
Q
F
I
R
M
S
G
A
G
L
L
-----------------------------
4
PsiBlast_PDB
91.19
55%
-90
- C3 -
3ZFH
-
?
A:
[6-467]
----
Q
E
A
L
T
F
D
D
V
L
L
I
P
G
Y
S
E
V
L
--
P
K
D
V
S
L
K
T
R
L
T
-------
R
G
I
E
L
N
I
P
L
V
S
A
A
M
D
T
V
T
E
A
R
L
A
I
A
M
A
Q
E
G
G
I
G
I
I
H
K
N
M
G
I
E
Q
Q
A
A
E
V
R
K
V
--
K
K
H
E
T
-----------------------------------------------------------------------------------------------------------------------------
T
Y
P
L
A
S
K
--
D
E
Q
G
R
L
R
V
G
A
A
V
G
T
--
G
A
D
T
G
-
E
R
V
A
A
L
V
A
A
G
V
D
V
V
V
V
D
T
A
H
G
H
S
K
G
V
I
E
R
V
R
W
V
K
Q
T
F
P
-
D
V
Q
V
I
G
G
N
I
A
T
A
E
A
A
K
A
L
A
E
A
G
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
S
A
I
A
N
V
A
A
A
L
E
G
------
T
G
V
P
L
I
A
D
G
G
I
R
F
S
G
D
L
A
K
A
M
V
A
G
A
Y
C
V
M
M
G
S
M
F
A
G
T
E
E
A
P
-----------------------------------------------------------------
K
G
A
L
S
A
I
V
H
Q
L
M
G
G
L
R
A
A
M
G
Y
T
G
S
A
D
I
Q
Q
M
R
T
-----
Q
P
Q
F
V
R
I
T
G
A
--------------------------------
109
HHSearch
89.49
55%
-91
- C3 -
1VRD
-
?
A:
[1-457]
---
M
K
E
A
L
T
F
D
D
V
L
L
V
P
Q
Y
S
E
V
L
--
P
K
D
V
K
I
D
T
R
L
T
-------
R
Q
I
R
I
N
I
P
L
V
S
A
A
M
D
T
V
T
E
A
A
L
A
K
A
L
A
R
E
G
G
I
G
I
I
H
K
N
L
T
P
D
E
Q
A
R
Q
V
S
I
V
--
K
K
T
--------------------------------------------------------------------------------------------------------------------------
I
M
S
V
I
E
H
P
N
A
A
R
--
D
E
K
G
R
L
L
V
G
A
A
V
G
T
--
S
P
-
E
T
M
E
R
V
E
K
L
V
K
A
G
V
D
V
I
V
I
D
T
A
H
G
H
S
R
R
V
I
E
T
L
E
M
I
K
A
D
Y
P
-
D
L
P
V
V
A
G
N
V
A
T
P
E
G
T
E
A
L
I
K
A
G
A
D
A
V
K
V
G
V
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
M
E
C
S
E
V
A
R
K
------
Y
D
V
P
I
I
A
D
G
G
I
R
Y
S
G
D
I
V
K
A
L
A
A
G
A
E
S
V
M
V
G
S
I
F
A
G
T
E
E
A
P
G
E
T
I
L
Y
Q
G
R
K
Y
K
A
Y
R
G
M
G
----------------------------------------
I
E
G
M
V
P
Y
K
G
T
V
K
D
V
V
H
Q
L
V
G
G
L
R
S
G
M
G
Y
I
G
A
R
T
I
K
E
L
Q
E
-----
K
A
V
F
V
K
I
T
----------------------------------
1
PsiBlast_PDB
88.40
53%
-91
- C3 -
1VRD
-
?
A:
[1-457]
---
M
K
E
A
L
T
F
D
D
V
L
L
V
P
Q
Y
S
E
V
L
--
P
K
D
V
K
I
D
T
R
L
T
-------
R
Q
I
R
I
N
I
P
L
V
S
A
A
M
D
T
V
T
E
A
A
L
A
K
A
L
A
R
E
G
G
I
G
I
I
H
K
N
L
T
P
D
E
Q
A
R
Q
V
S
I
V
--
K
K
T
--------------------------------------------------------------------------------------------------------------------------
I
M
S
V
I
E
H
P
N
A
A
R
--
D
E
K
G
R
L
L
V
G
A
A
V
G
T
---
S
P
E
T
M
E
R
V
E
K
L
V
K
A
G
V
D
V
I
V
I
D
T
A
H
G
H
S
R
R
V
I
E
T
L
E
M
I
K
A
D
Y
P
-
D
L
P
V
V
A
G
N
V
A
T
P
E
G
T
E
A
L
I
K
A
G
A
D
A
V
K
V
G
V
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
M
E
C
S
E
V
A
R
K
------
Y
D
V
P
I
I
A
D
G
G
I
R
Y
S
G
D
I
V
K
A
L
A
A
G
A
E
S
V
M
V
G
S
I
F
A
G
T
E
E
A
P
G
E
T
I
L
Y
Q
G
R
K
Y
K
A
Y
R
G
M
G
----------------------------------------
I
E
G
M
V
P
Y
K
G
T
V
K
D
V
V
H
Q
L
V
G
G
L
R
S
G
M
G
Y
I
G
A
R
T
I
K
E
L
Q
E
-----
K
A
V
F
V
K
I
T
----------------------------------
11
PsiBlast_PDB
87.53
49%
-83
- C3 -
2CU0
1
IMDH_PYRHO
A:
[15-480]
-------
Y
T
F
D
D
V
L
L
I
P
Q
A
T
E
V
E
--
P
K
D
V
D
V
S
T
R
I
T
-------
P
N
V
K
L
N
I
P
I
L
S
A
A
M
D
T
V
T
E
W
E
M
A
V
A
M
A
R
E
G
G
L
G
V
I
H
R
N
M
G
I
E
E
Q
V
E
Q
V
K
R
V
--
K
R
A
E
------------------------------------------------------------------------------------------------------------------------------
K
Y
K
N
A
V
R
--
D
E
N
G
E
L
L
V
A
A
A
V
S
P
--
F
D
---
I
K
R
A
I
E
L
D
K
A
G
V
D
V
I
V
V
D
T
A
H
A
H
N
L
K
A
I
K
S
M
K
E
M
R
Q
K
V
--
D
A
D
F
I
V
G
N
I
A
N
P
K
A
V
D
D
L
T
F
A
--
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
T
A
V
A
M
V
A
D
R
A
Q
E
------
Y
G
L
Y
V
I
A
D
G
G
I
R
Y
S
G
D
I
V
K
A
I
A
A
G
A
D
A
V
M
L
G
N
L
L
A
G
T
K
E
A
P
G
K
E
V
I
I
N
G
R
K
Y
K
Q
Y
R
G
M
G
S
L
G
A
M
---
M
K
-------------------
Y
M
K
T
R
K
F
V
P
E
G
V
E
G
V
V
P
Y
R
G
T
V
S
E
V
L
Y
Q
L
V
G
G
L
K
A
G
M
G
Y
V
G
A
R
N
I
R
E
L
K
E
-----
K
G
E
F
V
I
I
T
H
A
G
I
K
E
S
H
P
H
D
I
I
I
T
N
E
A
P
N
--------------
108
HHSearch
87.52
49%
-82
- C3 -
2CU0
1
IMDH_PYRHO
A:
[10-480]
--
K
A
I
K
G
Y
T
F
D
D
V
L
L
I
P
Q
A
T
E
V
E
--
P
K
D
V
D
V
S
T
R
I
T
-------
P
N
V
K
L
N
I
P
I
L
S
A
A
M
D
T
V
T
E
W
E
M
A
V
A
M
A
R
E
G
G
L
G
V
I
H
R
N
M
G
I
E
E
Q
V
E
Q
V
K
R
V
--
K
R
A
E
------------------------------------------------------------------------------------------------------------------------------
K
Y
K
N
A
V
R
--
D
E
N
G
E
L
L
V
A
A
A
V
----
S
P
F
D
-
I
K
R
A
I
E
L
D
K
A
G
V
D
V
I
V
V
D
T
A
H
A
H
N
L
K
A
I
K
S
M
K
E
M
R
Q
K
V
--
D
A
D
F
I
V
G
N
I
A
N
P
K
A
V
D
D
L
--
T
F
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
T
A
V
A
M
V
A
D
R
A
Q
E
------
Y
G
L
Y
V
I
A
D
G
G
I
R
Y
S
G
D
I
V
K
A
I
A
A
G
A
D
A
V
M
L
G
N
L
L
A
G
T
K
E
A
P
G
K
E
V
I
I
N
G
R
K
Y
K
Q
Y
R
G
M
G
S
L
G
A
M
---
M
K
------------------Y
M
K
T
R
-
K
F
V
P
E
G
V
E
G
V
V
P
Y
R
G
T
V
S
E
V
L
Y
Q
L
V
G
G
L
K
A
G
M
G
Y
V
G
A
R
N
I
R
E
L
K
E
-----
K
G
E
F
V
I
I
T
H
A
G
I
K
E
S
H
P
H
D
I
I
I
T
N
E
A
P
N
--------------
111
HHSearch
85.03
52%
-97
- C3 -
1EEP
1
IMDH_BORBU
A:
[4-390]
-
K
I
T
K
E
A
L
T
F
D
D
V
S
L
I
P
R
K
S
S
V
L
--
P
S
E
V
S
L
K
T
Q
L
T
-------
K
N
I
S
L
N
I
P
F
L
S
S
A
M
D
T
V
T
E
S
Q
M
A
I
A
I
A
K
E
G
G
I
G
I
I
H
K
N
M
S
I
E
A
Q
R
K
E
I
E
K
V
--
K
T
Y
K
------------------------------------------------------------------------------------------------------------------------------
D
F
P
N
A
C
K
--
D
L
N
N
K
L
R
V
G
A
A
V
S
I
--
D
I
-
D
T
I
E
R
V
E
E
L
V
K
A
H
V
D
I
L
V
I
D
S
A
H
G
H
S
T
R
I
I
E
L
I
K
K
I
K
T
K
Y
P
-
N
L
D
L
I
A
G
N
I
V
T
K
E
A
A
L
D
L
I
S
V
G
A
D
C
L
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
T
A
I
C
D
V
Y
E
A
C
N
N
------
T
N
I
C
I
I
A
D
G
G
I
R
F
S
G
D
V
V
K
A
I
A
A
G
A
D
S
V
M
I
G
N
L
F
A
G
T
K
E
S
P
S
E
E
I
I
Y
N
G
K
K
F
K
S
------------------------------------------------
M
V
P
Y
S
G
K
L
K
D
I
L
T
Q
L
K
G
G
L
M
S
G
M
G
Y
L
G
A
A
T
I
S
D
L
K
I
-----
N
S
K
F
V
K
I
S
H
S
--------------------------------
73
PsiBlast_CBE
82.74
37%
-85
- C3 -
4AF0
2
?
A:
[61-537]
--------
T
Y
N
D
F
L
V
L
P
G
H
I
N
F
P
--
A
S
D
V
S
L
Q
S
K
A
T
-------
K
N
I
V
L
N
T
P
F
L
S
S
P
M
D
T
V
T
E
D
R
M
A
I
A
L
A
L
H
G
G
L
G
I
I
H
H
N
C
S
A
E
E
Q
A
A
M
V
R
R
V
--
K
K
Y
E
N
------------------------------------------------------------------------------------------------------------------------------
Y
P
Y
A
S
K
VP
E
S
K
-
Q
L
Y
C
G
A
A
I
G
T
R
P
G
D
K
D
---
R
L
K
L
L
A
E
A
G
L
D
V
V
V
L
D
S
S
Q
G
N
S
V
Y
Q
I
E
F
I
K
W
I
K
Q
T
Y
P
-
K
I
D
V
I
A
G
N
V
V
T
R
E
Q
A
A
Q
L
I
A
A
G
A
D
G
L
R
I
G
M
G
S
G
S
I
C
I
T
Q
E
V
M
A
V
G
R
P
Q
G
T
A
V
Y
A
V
A
E
F
A
S
R
------
F
G
I
P
C
I
A
D
G
G
I
G
N
I
G
H
I
A
K
A
L
A
L
G
A
S
A
V
M
M
G
G
L
L
A
G
T
T
E
S
P
G
E
Y
F
Y
H
E
G
K
R
V
K
V
Y
R
G
M
G
S
I
E
A
M
EHT------GLDNAATA
R
Y
F
S
E
A
-
D
A
---
V
K
V
A
Q
G
V
S
G
D
V
A
D
K
G
S
I
N
K
F
V
P
Y
L
F
T
G
L
Q
H
S
L
Q
D
A
A
I
K
S
V
S
E
L
H
S
C
A
R
S
G
S
L
R
F
E
L
R
T
A
S
--------------------------------
72
PsiBlast_CBE
82.58
38%
-85
- C3 -
4AF0
2
?
B:
[61-537]
--------
T
Y
N
D
F
L
V
L
P
G
H
I
N
F
P
--
A
S
D
V
S
L
Q
S
K
A
T
-------
K
N
I
V
L
N
T
P
F
L
S
S
P
M
D
T
V
T
E
D
R
M
A
I
A
L
A
L
H
G
G
L
G
I
I
H
H
N
C
S
A
E
E
Q
A
A
M
V
R
R
V
--
K
K
Y
E
N
------------------------------------------------------------------------------------------------------------------------------
Y
P
Y
A
S
K
VP
E
S
K
-
Q
L
Y
C
G
A
A
I
G
T
RP
G
D
K
D
---
R
L
K
L
L
A
E
A
G
L
D
V
V
V
L
D
S
S
Q
G
N
S
V
Y
Q
I
E
F
I
K
W
I
K
Q
T
Y
P
-
K
I
D
V
I
A
G
N
V
V
T
R
E
Q
A
A
Q
L
I
A
A
G
A
D
G
L
R
I
G
M
G
S
G
S
I
C
I
T
Q
E
V
M
A
V
G
R
P
Q
G
T
A
V
Y
A
V
A
E
F
A
S
R
------
F
G
I
P
C
I
A
D
G
G
I
G
N
I
G
H
I
A
K
A
L
A
L
G
A
S
A
V
M
M
G
G
L
L
A
G
T
T
E
S
P
G
E
Y
F
Y
H
E
G
K
R
V
K
V
Y
R
G
M
G
S
I
E
A
M
EHT------GLDNAATA
R
Y
F
S
E
A
-
D
A
---
V
K
V
A
Q
G
V
S
G
D
V
A
D
K
G
S
I
N
K
F
V
P
Y
L
F
T
G
L
Q
H
S
L
Q
D
A
G
I
K
S
V
S
E
L
H
S
CARSG
S
L
R
F
E
L
R
T
A
S
--------------------------------
112
HHSearch
82.57
51%
-99
- C3 -
3FFS
-
IMDH_CRYPV
A:
[4-379]
-
K
N
I
G
K
G
L
T
F
E
D
I
L
L
V
P
N
Y
S
E
V
L
--
P
R
E
V
S
L
E
T
K
L
T
-------
K
N
V
S
L
K
I
P
L
I
S
S
A
M
D
T
V
T
E
H
L
M
A
V
G
M
A
R
L
G
G
I
G
I
I
H
K
N
M
D
M
E
S
Q
V
N
E
V
-----
L
K
V
K
N
W
I
------------------------------------------------------------------------------------------------------------------------
A
Y
S
N
---
E
N
L
--
D
N
K
G
R
L
R
V
G
A
A
I
G
V
-----
N
-
I
E
R
A
K
L
L
V
E
A
G
V
D
V
I
V
L
D
S
A
H
G
H
S
L
N
I
I
R
T
L
K
E
I
K
S
K
M
--
N
I
D
V
I
V
G
N
V
V
T
E
E
A
T
K
E
L
I
E
N
G
A
D
G
I
K
V
G
I
---------
I
V
A
G
V
G
V
P
Q
I
T
A
I
E
K
C
S
S
V
A
S
K
------
F
G
I
P
I
I
A
D
G
G
I
R
Y
S
G
D
I
G
K
A
L
A
V
G
A
S
S
V
M
I
G
S
I
L
A
G
T
E
E
S
P
G
E
K
E
L
I
G
D
T
V
Y
K
Y
------------------------------------------------
R
V
K
Y
K
G
E
M
E
G
V
V
Y
Q
L
V
G
G
L
R
S
C
M
G
Y
L
G
S
A
S
I
E
E
L
W
K
-----
K
S
S
Y
V
E
I
T
T
S
--------------------------------
107
HHSearch
80.47
30%
-82
- C3 -
1ME8
3
IMDH_TRIFO
A:
[7-492]
----
E
P
C
H
T
F
N
E
Y
L
L
I
P
G
L
S
T
V
D
CI
P
S
N
V
N
L
S
T
P
L
V
K
F
Q
KGQQ
S
E
I
N
L
K
I
P
L
V
S
A
I
M
Q
S
V
S
G
E
K
M
A
I
A
L
A
R
E
G
G
I
S
F
I
F
G
S
Q
S
I
E
S
Q
A
A
M
V
H
A
V
K
N
F
K
A
---------------------------------------------------------------------------------------------------------------------------------
H
N
E
L
V
--
D
S
Q
K
R
Y
L
V
G
A
G
I
N
T
--
R
--
D
F
R
E
R
V
P
A
L
V
E
A
G
A
D
V
L
C
I
D
S
S
D
G
F
S
E
W
Q
K
I
T
I
G
W
I
R
E
K
Y
G
D
K
V
K
V
G
A
G
N
I
V
D
G
E
G
F
R
Y
L
A
D
A
G
A
D
F
I
K
I
G
I
G
G
G
S
I
C
I
T
R
E
Q
K
G
I
G
R
G
Q
A
T
A
V
I
D
V
V
A
E
R
N
K
Y
F
E
ET
G
I
Y
I
P
V
C
S
D
G
G
I
V
Y
D
Y
H
M
T
L
A
L
A
M
G
A
D
F
I
M
L
G
R
Y
F
A
R
F
E
E
S
P
T
R
K
V
T
I
N
G
S
V
M
K
E
Y
W
G
E
G
S
S
R
A
R
---
N
W
----------------------------
E
G
V
D
S
Y
V
P
Y
A
G
K
L
K
D
N
V
E
A
S
L
N
K
V
K
S
T
M
C
N
C
G
A
L
T
I
P
Q
L
Q
S
-----
K
A
K
I
T
L
V
S
S
V
S
I
V
E
G
G
A
H
D
V
I
---------------------
70
PsiBlast_CBE
74.22
52%
-81
- C3 -
5AHM
3
?
A:
[70-397]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
V
T
-
E
A
R
L
A
I
A
M
A
Q
E
----
G
G
I
G
I
I
H
K
N
-----
M
G
I
E
Q
Q
A
A
E
V
R
K
V
K
K
H
E
T
A
K
A
K
T
Y
P
L
A
S
K
--
D
E
Q
G
R
L
R
V
G
A
A
V
G
T
--
G
A
D
T
G
-
E
R
V
A
A
L
V
A
A
G
V
D
V
V
V
V
D
T
A
H
G
H
S
K
G
V
I
E
R
V
R
W
V
K
Q
T
F
P
-
D
V
Q
V
I
G
G
N
I
A
T
A
E
A
A
K
A
L
A
E
A
G
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
S
A
I
A
N
V
A
A
A
L
E
G
------
T
G
V
P
L
I
A
D
G
G
I
R
F
S
G
D
L
A
K
A
M
V
A
G
A
Y
C
V
M
M
G
S
M
F
A
G
T
E
E
A
P
G
E
I
E
L
F
Q
G
R
S
Y
K
S
Y
R
G
M
G
S
L
----------------------------------
V
P
E
G
I
E
G
R
V
P
Y
K
G
A
L
S
A
I
V
H
Q
L
M
G
G
L
R
A
A
M
G
Y
T
G
S
A
D
I
Q
Q
M
R
T
-----
Q
P
Q
F
V
R
I
T
G
A
G
M
A
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
R
------------
69
PsiBlast_CBE
73.94
52%
-78
- C3 -
5AHM
4
?
B:
[70-397]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
V
T
-
E
A
R
L
A
I
A
M
A
Q
E
----
G
G
I
G
I
I
H
K
N
-----
M
G
I
E
Q
Q
A
A
E
V
R
K
V
K
K
H
E
T
----
T
Y
P
L
A
S
K
--
D
E
Q
G
R
L
R
V
G
A
A
V
G
T
--
G
A
D
T
G
-
E
R
V
A
A
L
V
A
A
G
V
D
V
V
V
V
D
T
A
H
G
H
S
K
G
V
I
E
R
V
R
W
V
K
Q
T
F
P
-
D
V
Q
V
I
G
G
N
I
A
T
A
E
A
A
K
A
L
A
E
A
G
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
S
A
I
A
N
V
A
A
A
L
E
G
------
T
G
V
P
L
I
A
D
G
G
I
R
F
S
G
D
L
A
K
A
M
V
A
G
A
Y
C
V
M
M
G
S
M
F
A
G
T
E
E
A
P
G
E
I
E
L
F
Q
G
R
S
Y
K
S
Y
R
G
M
G
-------------------------------------
P
E
G
I
E
G
R
V
P
Y
K
G
A
L
S
A
I
V
H
Q
L
M
G
G
L
R
A
A
M
G
Y
T
G
S
A
D
I
Q
Q
M
R
T
-----
Q
P
Q
F
V
R
I
T
G
A
G
M
A
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
R
------------
32
PsiBlast_CBE
71.38
53%
-88
- C3 -
4QM1
3
?
B:
[102-383]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
Q
Q
A
E
Q
V
D
K
V
K
--
R
S
G
G
L
L
-
V
G
A
A
V
G
V
---
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
---
E
K
------------------------
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
Q
F
I
R
M
S
G
A
G
L
L
-----
H
V
Q
I
T
K
E
A
P
N
Y
S
------------
42
PsiBlast_CBE
71.08
53%
-89
- C3 -
4MYA
3
?
B:
[102-382]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
Q
Q
A
E
Q
V
D
K
V
K
--
R
S
G
G
L
L
-
V
G
A
A
V
G
V
---
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
---
E
K
------------------------
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
Q
F
I
R
M
S
G
A
G
L
L
E
S
H
P
H
H
V
Q
I
T
K
E
A
P
N
Y
-------------
29
PsiBlast_CBE
70.97
55%
-88
- C3 -
4FO4
3
?
B:
[95-363]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
R
V
G
A
A
V
G
A
--
A
P
G
N
E
-
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
---
S
-------------------------
K
L
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
R
------------
52
PsiBlast_CBE
70.40
53%
-92
- C3 -
4MY8
4
?
C:
[102-366]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
Q
Q
A
E
Q
V
D
K
V
K
--
R
S
G
G
L
L
-
V
G
A
A
V
G
V
---
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
---
E
K
------------------------
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
Q
F
I
R
M
S
G
A
G
L
L
-----------------------------
53
PsiBlast_CBE
70.20
53%
-88
- C3 -
4MY8
7
?
B:
[102-366]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
Q
Q
A
E
Q
V
D
K
V
K
--
R
S
G
G
L
L
-
V
G
A
A
V
G
V
---
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
---
E
K
-------------------------
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
Q
F
I
R
M
S
G
A
G
L
L
-----------------------------
17
PsiBlast_PDB
70.09
55%
-86
- C3 -
4X3Z
4
?
A:
[95-363]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
R
V
G
A
A
V
G
A
--
A
P
G
N
E
-
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
---
S
--------------------------
L
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
-------------
24
PsiBlast_CBE
69.97
55%
-87
- C3 -
4X3Z
3
?
B:
[95-363]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
R
V
G
A
A
V
G
A
--
A
P
G
N
E
-
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
---
S
-------------------------
K
L
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
R
L
-----------
15
PsiBlast_PDB
69.77
55%
-96
- C3 -
4QQ3
3
?
A:
[95-344]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
R
V
G
A
A
V
G
A
--
A
P
G
N
E
-
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
-------
G
R
S
Y
K
A
Y
R
G
M
G
-------------------------------------------
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
Q
F
V
R
I
S
G
A
--------------------------------
20
PsiBlast_PDB
69.65
53%
-87
- C3 -
4MYA
4
?
A:
[102-382]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
Q
Q
A
E
Q
V
D
K
V
K
--
R
S
G
G
L
L
-
V
G
A
A
V
G
V
---
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
---
E
K
--------------------
K
---
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
Q
F
I
R
M
S
G
A
G
L
L
E
S
H
P
H
H
V
Q
I
T
K
E
A
P
N
Y
-------------
18
PsiBlast_PDB
69.13
53%
-87
- C3 -
4MY8
9
?
A:
[102-367]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
Q
Q
A
E
Q
V
D
K
V
K
--
R
S
G
G
L
L
-
V
G
A
A
V
G
V
---
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
---
E
K
G
S
K
----------------------
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
Q
F
I
R
M
S
G
A
G
L
L
E
----------------------------
26
PsiBlast_CBE
69.12
55%
-88
- C3 -
4IX2
3
?
D:
[95-363]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
R
V
G
A
A
V
G
A
--
A
P
G
N
E
-
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
--------------------------------------
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
-------------
25
PsiBlast_CBE
68.79
55%
-89
- C3 -
4QNE
3
?
B:
[95-363]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
R
V
G
A
A
V
G
A
--
A
P
G
N
E
-
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
---
S
--------------------------
L
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
R
L
-----------
33
PsiBlast_CBE
68.71
53%
-87
- C3 -
4QM1
3
?
A:
[102-376]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
Q
Q
A
E
Q
V
D
K
V
K
--
R
S
G
G
L
L
-
V
G
A
A
V
G
V
---
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
---
E
K
--------------------------
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
Q
F
I
R
M
S
G
A
G
L
L
------
V
Q
I
T
-------------------
16
PsiBlast_PDB
68.71
55%
-86
- C3 -
4QNE
3
?
A:
[95-363]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
R
V
G
A
A
V
G
A
--
A
P
G
N
E
-
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
---
S
--------------------------
L
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
R
L
-----------
31
PsiBlast_CBE
68.70
53%
-87
- C3 -
4QM1
3
?
C:
[102-375]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
Q
Q
A
E
Q
V
D
K
V
K
--
R
S
G
G
L
L
-
V
G
A
A
V
G
V
---
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
-------------------------------
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
Q
F
I
R
M
S
G
A
G
L
L
------
V
Q
I
--------------------
27
PsiBlast_CBE
68.70
55%
-88
- C3 -
4IX2
3
?
C:
[95-363]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
R
V
G
A
A
V
G
A
--
A
P
G
N
E
-
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
--------------------------------------
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
-------------
30
PsiBlast_CBE
68.60
53%
-84
- C3 -
4QM1
3
?
D:
[102-376]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
Q
Q
A
E
Q
V
D
K
V
K
--
R
S
G
G
L
L
-
V
G
A
A
V
G
V
---
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
---
E
--------------------------
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
Q
F
I
R
M
S
G
A
G
L
L
E
S
----
V
Q
I
T
-------------------
28
PsiBlast_CBE
68.41
55%
-84
- C3 -
4IX2
2
?
B:
[95-363]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
R
V
G
A
A
V
G
A
--
A
P
G
N
E
-
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
--------------------------------------
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
R
------------