@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0528: (2015-12-02 )
MVTINKDVLAKEKVVVAPEPIEKSEQIFDNGMIKQTTNEGIKEIRKTLNLSELREKTAEELLNLAEERKISTNGKGNGRMLKQEMIFNLMKKMSEEGGITIGSGVVEILPDGFGFLRSANANYAPSTDDVYISNGQIKKFNLRTGDIVCGEIRPPSDKERYFTLTKVQGINFTEVSELRKYVHFDNLLPLYPEESLILENNSSGDNKKDINMRAVDIVAPLGKGQRALIVAPPRTGKTILLQQMAHSIATNHPEIELIVLLIDERPEEVTDMMRSVKGEVVSSTFDEPAYRHVQLAEIVIEKAKRMVEHKKDVVILLDSITRLARAYNAIIPSSGKVLTGGVDSNALQRPKRFFGAARNIENGGSLTIIATALIETGSKMDEVIFEEFKGTGNAEIILDRKLADKRIFPAIDITKSGTRKEELLIDKAILNKIWVLRRILSPMGPVEAMEFLRDKLLLTKSNSDFFNSMNN
Atome Classification :
(25 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
V
TI
N
K
D
VLAKE
K
V
V
VAPEPI
E
K
S
E
Q
I
F
DNGMIKQ
T
T
N
E
G
I
K
E
I
R
K
TL
N
L
S
E
L
R
E
K
T
A
E
E
L
L
N
L
A
E
ERKISTNGKGNGR
M
L
K
Q
E
M
I
F
N
L
M
K
K
M
SEEG
G
I
T
IG
S
G
V
V
E
ILPDG
F
G
F
L
RSANANYAPSTD
D
V
Y
ISNG
Q
I
K
K
F
NLRTG
D
I
V
CGEIRPPSDK
E
R
Y
F
T
L
T
K
VQGI
N
F
T
E
V
S
E
L
R
K
Y
V
H
FDNLLPLYPEE
S
L
I
L
ENNSSGDNKK
D
I
N
M
R
A
V
D
I
V
APLGKG
Q
R
A
L
I
V
APPRT
G
K
T
I
L
L
Q
Q
M
A
H
S
I
ATNHP
E
I
E
L
I
V
L
L
IDER
P
E
E
V
T
D
M
M
R
S
V
K
G
E
V
V
S
STFDE
P
A
Y
R
H
V
Q
L
A
E
I
V
I
E
K
A
K
R
M
V
E
HKK
D
V
V
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
A
IIPSSG
K
V
L
TGGVD
S
N
A
L
Q
R
P
K
R
F
F
G
AARNIENGG
S
L
T
I
I
A
T
A
L
I
ETGS
K
M
D
E
V
I
F
E
E
FKGTGN
A
E
I
I
L
DRKLADKRIF
P
A
I
DITKSGT
R
K
E
E
L
L
I
D
K
A
I
L
N
K
I
W
V
L
R
R
I
LSPM
G
P
V
E
A
M
E
F
L
R
D
K
L
L
L
TKSNS
D
F
F
NSMNN
21
PsiBlast_CBE
96.68
60%
-90
- C6 -
1XPU
5
RHO_ECOLI
F:
[1-416]
-----------------------------------------------
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
----
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
--
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-
36
PsiBlast_CBE
96.27
60%
-91
- C6 -
1PVO
2
RHO_ECOLI
F:
[1-416]
-----------------------------------------------
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
----
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
--
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-
29
PsiBlast_CBE
96.16
60%
-95
- C6 -
1XPR
5
RHO_ECOLI
C:
[1-416]
-----------------------------------------------
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
----
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
--
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-
38
PsiBlast_CBE
95.69
60%
-88
- C6 -
1PVO
3
RHO_ECOLI
D:
[1-416]
-----------------------------------------------
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
----
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
--
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-
27
PsiBlast_CBE
95.68
60%
-93
- C6 -
1XPR
7
RHO_ECOLI
E:
[1-416]
-----------------------------------------------
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
----
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
--
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
----
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-
24
PsiBlast_CBE
95.01
60%
-86
- C6 -
1XPU
6
RHO_ECOLI
C:
[1-416]
-----------------------------------------------
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
----
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
--
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-
26
PsiBlast_CBE
94.88
60%
-90
- C6 -
1XPR
6
RHO_ECOLI
F:
[1-416]
-----------------------------------------------
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
----
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
--
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-
37
PsiBlast_CBE
94.75
60%
-91
- C6 -
1PVO
3
RHO_ECOLI
E:
[1-416]
-----------------------------------------------
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
----
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
--
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
----
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-
25
PsiBlast_CBE
94.73
60%
-89
- C6 -
1XPU
6
RHO_ECOLI
B:
[1-416]
-----------------------------------------------
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
----
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
--
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-
3
PsiBlast_PDB
94.71
60%
-95
- C8 -
1XPU
5
RHO_ECOLI
A:
[1-416]
-----------------------------------------------
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
----
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
--
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-
28
PsiBlast_CBE
94.63
60%
-89
- C6 -
1XPR
4
RHO_ECOLI
D:
[1-416]
-----------------------------------------------
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
----
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
--
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-
23
PsiBlast_CBE
94.61
60%
-84
- C6 -
1XPU
5
RHO_ECOLI
D:
[1-416]
-----------------------------------------------
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
----
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
--
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-
39
PsiBlast_CBE
94.57
60%
-90
- C6 -
1PVO
3
RHO_ECOLI
C:
[1-416]
-----------------------------------------------
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
----
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
--
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-
1
PsiBlast_PDB
94.54
60%
-94
- C8 -
1PVO
3
RHO_ECOLI
A:
[1-416]
-----------------------------------------------
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
----
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
--
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-
22
PsiBlast_CBE
94.11
60%
-86
- C6 -
1XPU
6
RHO_ECOLI
E:
[1-416]
-----------------------------------------------
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
----
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
--
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
----
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-
2
PsiBlast_PDB
94.04
60%
-86
- C6 -
1XPR
5
RHO_ECOLI
A:
[1-416]
-----------------------------------------------
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
----
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
--
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-
30
PsiBlast_CBE
93.96
60%
-90
- C6 -
1XPR
6
RHO_ECOLI
B:
[1-416]
-----------------------------------------------
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
----
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
--
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-
33
PsiBlast_CBE
93.73
60%
-91
- C6 -
1XPO
6
RHO_ECOLI
D:
[1-416]
-----------------------------------------------
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
----
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
--
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-
35
PsiBlast_CBE
93.51
60%
-87
- C6 -
1XPO
6
RHO_ECOLI
B:
[1-416]
-----------------------------------------------
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
----
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
--
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-
34
PsiBlast_CBE
93.29
60%
-89
- C6 -
1XPO
6
RHO_ECOLI
C:
[1-416]
-----------------------------------------------
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
----
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
--
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-
31
PsiBlast_CBE
93.08
60%
-86
- C6 -
1XPO
5
RHO_ECOLI
F:
[1-416]
-----------------------------------------------
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
----
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
--
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-
32
PsiBlast_CBE
92.96
60%
-85
- C6 -
1XPO
6
RHO_ECOLI
E:
[1-416]
-----------------------------------------------
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
----
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
--
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
----
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-
4
PsiBlast_PDB
91.29
60%
-86
- C6 -
1XPO
5
RHO_ECOLI
A:
[1-416]
-----------------------------------------------
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
----
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
--
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-
5
PsiBlast_PDB
78.18
60%
-91
- C6 -
2HT1
3
RHO_ECOLI
A:
[53-376]
---------------------------------------------------------------------------------
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
D
G
F
G
F
L
R
S
A
D
S
S
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
A
R
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
E
R
G
N
G
--
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
S
G
K
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
----------------------------------------------------------------
41
PsiBlast_CBE
77.79
60%
-85
- C6 -
2HT1
3
RHO_ECOLI
B:
[53-376]
---------------------------------------------------------------------------------
K
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R
V
----------------------------------------------------------------