@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0611: (2015-12-03 )
MHRYDVVVVGGGHAGCEAAAAAARLGASTLLITHKISTIGEMSCNPAIGGVAKGIVVREVDALDGIMGRAIDQASIHSVILNSSRGAAVWGPRAQADRKLYKKAIQEIILNHDNLTVKEESVDDFLIESNSNGEPYIKAIITSSGKQILTSKVVLTTGTFLQGMVHIGEQTTPSGRMGDKSAVELANTLKKYDFKLGRLRTGTPPRLDRSTINWSILEEQVGNNPPMPFSYLTEKINQPQVSCFITYTNENTHRIIQANLHRSASSYLNDIVAPRYCPSIEAKVKKFAEKNSHQIFLEPEGLDNITVYPNGISNSLPIEVQREMINSIKGLENAEILRPGYAVEYDYIDPRELFHTLETKKVKGLYFAGQINGTTGYEEAAGQGIIAGINAALSASQKKESFVLHRTDSYIGVMIDDLVTKGVTEPYRLFTSRAEYRLAIRSDNADRRLTQKGYNISLVSYKRYSALQNKLKSIKQLEEKLESLKITPEQLRFCGIKISHDGIRKTALDLLSYPNIDWNKLQEIWPELTNVTRWNDNKADQTVIQVVDTRIQKKNADSSVTRWNDKTGYWNDSKTTSNTIKNEICEAVAIEAKYKPYLVRQEADMKFLREEMNTQIPTNFNYSQIKGLSSEVIEKLQAIKPATIGIAKQIQGITPAAIVSILVYLRNRKTKVAANSA
Atome Classification :
(20 SA)
.........10........20........30........40--------.........50.----.......60---.........70........80........90---...---.....100.......110.......120........130.......140.......150.......160.......170.....-..180..-.....190........200...----------.....210..-------.....220.......230...-.-.-------..240........-250.-......260..-...-..-270..----.....280....------..--------.----290........300.......310.......320.....----------..330.......340.......-350...-....360.......370.---..-...--.380.......390.......400.......410.......420.......430.......440.......450.......460--.......470.......480......--.490......--.---500...-.-----...510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
H
R
Y
D
V
V
V
VGGGHA
G
C
E
A
A
A
A
A
A
RLG
A
S
T
L
L
I
T
H
K
ISTIG---------EMSCNPAIGGVA----K
G
I
V
V
R
E
V
----
D
A
L
D
G
I
M
G
RAI
D
Q
A
S
I
H
S
V
I
LNSSRGAAVWG---PR
A
---
Q
A
D
R
K
L
Y
K
K
A
I
Q
E
I
I
LNHDN
L
T
V
KEE-SV
D
D
F
L
IESNSNGE
P
Y
I
K
A
I
ITSSG
K
Q
I
L
T
S
K
V
V
L
T
T
G
T
F
L
Q
G
M
V
HIGEQTTPSGRM-G
D
K
S
A
V
E
-
L
A
N
T
L
K
K
-
Y
DFKLGRLR-TGTP----------PRLDRSTI
N
W
-------
S
I
L
E
E
Q
VGNNPPM
P
F
S
Y
L
T
E
K-I-N-------QP
Q
-
V
S
C
F
I
T
YTN-EN
T
H
-
R
I
I
Q
A
N
L
H
R
S
A
-
S
S
Y
-
L
N
-
D
IVAP----RYCP
S
I
E
A
K
V
K
K
------
F
A
--------E----KN-S
H
Q
I
F
LEPEGLD
N
I
T
V
YPNGISNSL
P
I
E
V
Q
R
E
M
I
N
S
----------IKGLENAEILRPG
Y
A
V
E
Y
DYI
D
-
P
R
E
L
F
H
-
T
L
ETKKV
K
G
L
Y
F
A
G
QING---TT-GY
E
--
E
AAGQ
G
I
I
A
G
I
N
A
A
LSASQKK
E
S
F
V
L
HRTDS
Y
I
G
V
M
I
D
D
L
V
TKGVT
E
P
Y
R
L
F
TSRA
E
Y
R
L
A
I
RSDNADRRLTQKG
Y
N
I
S
L
V
S
Y
K
--
R
Y
S
A
L
Q
N
K
L
K
S
I
K
Q
L
E
E
K
L
E
SLKI
T
P
--
E
Q
L
RFCG
I
K
I--S---HD
G
I
R
K
-
T
-----
A
L
D
L
LSYPNI
D
W
N
K
L
Q
E
I
W
P
E
L
T
NVTRWNDNKA
D
Q
T
V
I
Q
V
V
D
T
R
I
QKKNADSSVTRWNDKTGYWNDSKTT
S
N
T
I
K
N
E
I
C
E
A
V
A
IEAKYK
P
Y
L
V
RQEA
D
M
K
F
L
R
E
E
MNTQIPTNF
N
Y
S
Q
I
KG
L
S
S
E
V
I
E
K
L
Q
AIKP
A
T
I
G
I
A
K
Q
IQGI
T
P
A
A
I
V
S
I
L
V
Y
L
RNRK
T
K
VAANSA
64
HHSearch
81.26
43%
-70
- C6 -
3CP8
1
MNMG_CHLTE
A:
[20-639]
-
H
M
Y
D
V
I
V
V
G
A
G
H
A
G
C
E
A
A
L
A
V
A
R
G
G
L
H
C
L
L
I
T
S
D
L
S
A
V
A
---------
R
M
S
C
N
P
A
I
G
G
V
A
----
K
G
Q
I
T
R
E
I
----
D
A
L
G
G
E
M
G
K
A
I
D
A
T
G
I
Q
F
R
M
L
N
R
S
K
G
P
A
M
H
S
---
P
R
A
---
Q
A
D
K
T
Q
Y
S
L
Y
M
R
R
I
V
E
H
E
P
N
I
D
L
L
Q
D
-
T
V
I
G
V
S
A
N
S
G
-----
K
F
S
S
V
T
V
R
S
G
R
A
I
Q
A
K
A
A
I
L
A
C
G
T
F
L
N
G
L
I
H
I
G
M
D
H
F
P
G
G
R
S
T
A
E
P
P
V
E
G
-
L
T
E
S
L
A
S
-
L
G
F
S
F
G
R
L
K
-
T
G
T
P
----------
P
R
I
D
S
R
S
V
D
Y
-------
T
I
V
T
E
Q
P
G
D
V
D
P
V
P
F
S
F
S
S
T
S
-
V
A
N
-------
R
N
L
-
V
S
C
Y
L
T
K
T
T
-
E
K
T
H
-
D
I
L
R
T
G
F
D
R
S
P
L
F
T
G
---------------
C
P
S
I
E
D
K
I
S
R
------
F
P
--------
D
----
K
S
-
S
H
H
I
F
L
E
P
E
G
T
D
T
V
E
M
Y
V
N
G
F
S
T
S
L
P
E
D
I
Q
I
A
G
L
R
S
----------
I
P
G
L
E
E
A
K
M
I
R
P
G
Y
A
I
E
Y
D
F
F
H
-
P
W
Q
I
R
S
-
T
M
E
T
R
P
V
E
N
L
F
F
A
G
Q
I
N
G
---
T
S
-
G
Y
E
--
E
A
A
A
Q
G
L
M
A
G
I
N
A
V
R
K
I
L
-
G
K
E
L
I
V
L
G
R
D
Q
A
Y
I
G
V
L
I
D
D
L
I
T
K
E
T
K
E
P
Y
R
M
F
T
S
S
A
E
H
R
L
I
L
R
H
D
N
A
D
L
R
L
R
K
I
G
Y
D
C
N
L
V
S
S
D
--
D
L
H
R
T
E
S
I
I
K
R
V
Q
H
C
L
E
V
M
K
T
A
K
V
T
P
--
A
E
I
N
T
L
L
M
N
K
GL
Q
---
E
L
K
T
P
A
-
R
-----
A
L
S
L
I
K
R
P
G
I
S
L
Q
D
I
L
E
H
S
L
S
V
R
S
A
-------------------------------------------
A
E
E
L
C
N
D
P
R
V
A
E
Q
V
Q
I
E
I
K
Y
E
G
Y
I
K
R
E
Q
L
V
A
D
R
I
A
R
L
D
S
L
H
I
P
D
N
F
N
Y
D
S
L
N
S
L
S
S
E
G
R
E
K
L
L
K
H
R
P
A
T
I
G
Q
A
S
R
I
L
G
V
S
P
S
D
V
S
I
L
M
I
R
L
------------
28
PsiBlast_CBE
81.24
40%
-75
- C6 -
3CP8
1
MNMG_CHLTE
B:
[20-639]
-
H
M
Y
D
V
I
V
V
G
A
G
H
A
G
C
E
A
A
L
A
V
A
R
G
G
L
H
C
L
L
I
T
S
D
L
S
A
V
A
---------
R
M
S
C
N
P
A
I
G
G
V
A
----
K
G
Q
I
T
R
E
I
----
D
A
L
G
G
E
M
G
K
A
I
D
A
T
G
I
Q
F
R
M
L
N
R
S
K
G
P
A
M
H
S
---
P
R
A
---
Q
A
D
K
T
Q
Y
S
L
Y
M
R
R
I
V
E
H
E
P
N
I
D
L
L
Q
D
-
T
V
--
I
G
V
S
A
N
S
G
---
K
F
S
S
V
T
V
R
S
G
R
A
I
Q
A
K
A
A
I
L
A
C
G
T
F
L
N
G
L
I
H
I
G
M
D
H
F
P
G
G
R
S
-
T
A
E
P
P
V
E
G
L
T
E
S
L
A
S
-
L
G
F
S
F
G
R
L
K
-
T
G
T
P
----------
P
R
I
D
S
R
S
V
D
Y
-------
T
I
V
T
E
Q
P
G
D
V
D
P
V
P
F
S
F
S
S
T
S
-
V
A
N
-------
R
N
L
-
V
S
C
Y
L
T
K
T
T
-
E
K
T
H
-
D
I
L
R
T
G
F
D
R
S
P
-
L
-
F
-
T
G
------------
C
P
S
I
E
D
K
I
S
R
------
F
P
--------
D
----
K
S
-
S
H
H
I
F
L
E
P
E
G
T
D
T
V
E
M
Y
V
N
G
F
S
T
S
L
P
E
D
I
Q
I
A
G
L
R
S
----------
I
P
G
L
E
E
A
K
M
I
R
P
G
Y
A
I
E
Y
D
F
F
H
-
P
W
Q
I
R
S
-
T
M
E
T
R
P
V
E
N
L
F
F
A
G
Q
I
N
G
---
T
S
-
G
Y
E
--
E
A
A
A
Q
G
L
M
A
G
I
N
-
A
V
R
K
I
L
G
K
E
L
I
V
L
G
R
D
Q
A
Y
I
G
V
L
I
D
D
L
I
T
K
E
T
K
E
P
Y
R
M
F
T
S
S
A
E
H
R
L
I
L
R
H
D
N
A
D
L
R
L
R
K
I
G
Y
D
C
N
L
V
S
S
D
--
D
L
H
R
T
E
S
I
I
K
R
V
Q
H
C
L
E
V
M
K
T
A
K
V
T
P
--
A
E
I
N
T
L
---
L
--
M
---
N
K
G
L
Q
E
-
L
KTPAR
A
L
S
L
I
K
R
P
G
I
---
S
L
Q
D
I
L
-------------------------------
E
H
S
L
S
V
R
S
A
A
E
E
L
C
N
D
P
R
---------
V
A
E
Q
V
Q
I
E
I
K
Y
E
G
Y
I
K
R
E
Q
L
V
A
D
R
I
A
R
L
D
S
L
H
I
P
D
N
F
N
Y
D
S
L
N
S
L
S
S
E
G
R
E
K
L
L
K
H
R
P
A
T
I
G
Q
A
S
R
I
L
G
V
S
P
S
D
V
S
I
L
M
I
R
L
------------
5
PsiBlast_PDB
81.22
40%
-74
- C6 -
3CP8
1
MNMG_CHLTE
A:
[20-639]
-
H
M
Y
D
V
I
V
V
G
A
G
H
A
G
C
E
A
A
L
A
V
A
R
G
G
L
H
C
L
L
I
T
S
D
L
S
A
V
A
---------
R
M
S
C
N
P
A
I
G
G
V
A
----
K
G
Q
I
T
R
E
I
----
D
A
L
G
G
E
M
G
K
A
I
D
A
T
G
I
Q
F
R
M
L
N
R
S
K
G
P
A
M
H
S
---
P
R
A
---
Q
A
D
K
T
Q
Y
S
L
Y
M
R
R
I
V
E
H
E
P
N
I
D
L
L
Q
D
-
T
V
--
I
G
V
S
A
N
S
G
---
K
F
S
S
V
T
V
R
S
G
R
A
I
Q
A
K
A
A
I
L
A
C
G
T
F
L
N
G
L
I
H
I
G
M
D
H
F
P
G
G
R
S
-
T
A
E
P
P
V
E
G
L
T
E
S
L
A
S
-
L
G
F
S
F
G
R
L
K
-
T
G
T
P
----------
P
R
I
D
S
R
S
V
D
Y
-------
T
I
V
T
E
Q
P
G
D
V
D
P
V
P
F
S
F
S
S
T
S
-
V
A
N
-------
R
N
L
-
V
S
C
Y
L
T
K
T
T
-
E
K
T
H
-
D
I
L
R
T
G
F
D
R
S
P
-
L
-
F
-
T
G
------------
C
P
S
I
E
D
K
I
S
R
------
F
P
--------
D
----
K
S
-
S
H
H
I
F
L
E
P
E
G
T
D
T
V
E
M
Y
V
N
G
F
S
T
S
L
P
E
D
I
Q
I
A
G
L
R
S
----------
I
P
G
L
E
E
A
K
M
I
R
P
G
Y
A
I
E
Y
D
F
F
H
-
P
W
Q
I
R
S
-
T
M
E
T
R
P
V
E
N
L
F
F
A
G
Q
I
N
G
---
T
S
-
G
Y
E
--
E
A
A
A
Q
G
L
M
A
G
I
N
-
A
V
R
K
I
L
G
K
E
L
I
V
L
G
R
D
Q
A
Y
I
G
V
L
I
D
D
L
I
T
K
E
T
K
E
P
Y
R
M
F
T
S
S
A
E
H
R
L
I
L
R
H
D
N
A
D
L
R
L
R
K
I
G
Y
D
C
N
L
V
S
S
D
--
D
L
H
R
T
E
S
I
I
K
R
V
Q
H
C
L
E
V
M
K
T
A
K
V
T
P
--
A
E
I
N
T
L
---
L
--
M
---
N
K
G
L
Q
E
-
L
KTPAR
A
L
S
L
I
K
R
P
G
I
---
S
L
Q
D
I
L
-------------------------------
E
H
S
L
S
V
R
S
A
A
E
E
L
C
N
D
P
R
---------
V
A
E
Q
V
Q
I
E
I
K
Y
E
G
Y
I
K
R
E
Q
L
V
A
D
R
I
A
R
L
D
S
L
H
I
P
D
N
F
N
Y
D
S
L
N
S
L
S
S
E
G
R
E
K
L
L
K
H
R
P
A
T
I
G
Q
A
S
R
I
L
G
V
S
P
S
D
V
S
I
L
M
I
R
L
------------
27
PsiBlast_CBE
80.90
40%
-76
- C6 -
3CP8
1
MNMG_CHLTE
C:
[20-639]
-
H
M
Y
D
V
I
V
V
G
A
G
H
A
G
C
E
A
A
L
A
V
A
R
G
G
L
H
C
L
L
I
T
S
D
L
S
A
V
A
---------
R
M
S
C
N
P
A
I
G
G
V
A
----
K
G
Q
I
T
R
E
I
----
D
A
L
G
G
E
M
G
K
A
I
D
A
T
G
I
Q
F
R
M
L
N
R
S
K
G
P
A
M
H
S
---
P
R
A
---
Q
A
D
K
T
Q
Y
S
L
Y
M
R
R
I
V
E
H
E
P
N
I
D
L
L
Q
D
-
T
V
--
I
G
V
S
A
N
S
G
---
K
F
S
S
V
T
V
R
S
G
R
A
I
Q
A
K
A
A
I
L
A
C
G
T
F
L
N
G
L
I
H
I
G
M
D
H
F
P
G
G
R
S
-
T
A
E
P
P
V
E
G
L
T
E
S
L
A
S
-
L
G
F
S
F
G
R
L
K
-
T
G
T
P
----------
P
R
I
D
S
R
S
V
D
Y
-------
T
I
V
T
E
Q
P
G
D
V
D
P
V
P
F
S
F
S
S
T
S
-
V
A
N
-------
R
N
L
-
V
S
C
Y
L
T
K
T
T
-
E
K
T
H
-
D
I
L
R
T
G
F
D
R
S
P
-
L
-
F
-
T
G
------------
C
P
S
I
E
D
K
I
S
R
------
F
P
--------
D
----
K
S
-
S
H
H
I
F
L
E
P
E
G
T
D
T
V
E
M
Y
V
N
G
F
S
T
S
L
P
E
D
I
Q
I
A
G
L
R
S
----------
I
P
G
L
E
E
A
K
M
I
R
P
G
Y
A
I
E
Y
D
F
F
H
-
P
W
Q
I
R
S
-
T
M
E
T
R
P
V
E
N
L
F
F
A
G
Q
I
N
G
---
T
S
-
G
Y
E
--
E
A
A
A
Q
G
L
M
A
G
I
N
-
A
V
R
K
I
L
G
K
E
L
I
V
L
G
R
D
Q
A
Y
I
G
V
L
I
D
D
L
I
T
K
E
T
K
E
P
Y
R
M
F
T
S
S
A
E
H
R
L
I
L
R
H
D
N
A
D
L
R
L
R
K
I
G
Y
D
C
N
L
V
S
S
D
--
D
L
H
R
T
E
S
I
I
K
R
V
Q
H
C
L
E
V
M
K
T
A
K
V
T
P
--
A
E
I
N
T
L
---
L
--
M
---
N
K
G
L
Q
E
-
L
KTPAR
A
L
S
L
I
K
R
P
G
I
---
S
L
Q
D
I
L
-------------------------------
E
H
S
L
S
V
R
S
A
A
E
E
L
C
N
D
P
R
---------
V
A
E
Q
V
Q
I
E
I
K
Y
E
G
Y
I
K
R
E
Q
L
V
A
D
R
I
A
R
L
D
S
L
H
I
P
D
N
F
N
Y
D
S
L
N
S
L
S
S
E
G
R
E
K
L
L
K
H
R
P
A
T
I
G
Q
A
S
R
I
L
G
V
S
P
S
D
V
S
I
L
M
I
R
L
------------
62
HHSearch
78.03
47%
-74
- C6 -
3CES
-
MNMG_ECOLI
A:
[4-550]
P
D
P
F
D
V
I
I
I
G
G
G
H
A
G
T
E
A
A
M
A
A
A
R
M
G
Q
Q
T
L
L
L
T
H
N
I
D
T
L
G
---------
Q
M
S
C
N
P
A
I
G
G
I
G
----
K
G
H
L
V
K
E
V
----
D
A
L
G
G
L
M
A
K
A
I
D
Q
A
G
I
Q
F
R
I
L
N
A
S
K
G
P
A
V
R
A
---
T
R
A
---
Q
A
D
R
V
L
Y
R
Q
A
V
R
T
A
L
E
N
Q
P
N
L
M
I
F
Q
Q
-
A
V
E
D
L
I
V
E
N
D
-----
R
V
V
G
A
V
T
Q
M
G
L
K
F
R
A
K
A
V
V
L
T
V
G
T
F
L
D
G
K
I
H
I
G
--------------
S
I
P
-
L
S
R
R
L
R
E
-
L
P
L
R
V
G
R
L
K
-
T
G
T
P
----------
P
R
I
D
A
R
T
I
D
F
-------
S
V
L
A
Q
Q
H
G
D
N
P
M
P
V
F
S
F
M
G
N
A
S
Q
-
H
-------
P
Q
Q
-
V
P
C
Y
I
T
H
T
N
-
E
K
T
H
-
D
V
I
R
S
N
L
D
R
S
---------------------
P
S
I
E
D
K
V
M
R
------
F
A
--------
D
----
R
N
-
Q
H
Q
I
F
L
E
P
E
G
L
T
S
N
E
I
Y
P
N
G
I
S
T
S
L
P
F
D
V
Q
M
Q
I
V
R
S
----------
M
Q
G
M
E
N
A
K
I
V
R
P
G
Y
A
I
E
Y
D
F
F
D
-
P
R
D
L
K
P
-
T
L
E
S
K
F
I
Q
G
L
F
F
A
G
Q
I
N
G
---
T
T
-
G
Y
E
--
E
A
A
A
Q
G
L
L
A
G
L
N
A
A
R
L
S
A
-
D
K
E
G
W
A
P
A
R
S
Q
A
Y
L
G
V
L
V
D
D
L
C
T
L
G
T
K
E
P
Y
R
M
F
T
S
R
A
E
Y
R
L
M
L
R
E
D
N
A
D
L
R
L
T
E
I
G
R
E
L
G
L
V
D
D
E
--
R
W
A
R
F
N
E
K
L
E
N
I
E
R
E
R
Q
R
L
K
S
T
W
V
T
P
--
S
A
E
A
A
A
E
V
N
A
--
H
LTA
P
L
S
R
E
A
-
S
-----
G
E
D
L
L
R
R
P
E
M
T
Y
E
K
L
T
T
L
T
P
F
A
P
------------------------------------------------
A
L
T
D
E
Q
A
A
E
Q
V
E
I
Q
V
K
Y
E
G
---------------------------------------------------------------------------------
2
PsiBlast_PDB
76.65
45%
-71
- C6 -
3CES
-
MNMG_ECOLI
A:
[7-550]
---
F
D
V
I
I
I
G
G
G
H
A
G
T
E
A
A
M
A
A
A
R
M
G
Q
Q
T
L
L
L
T
H
N
I
D
T
L
G
---------
Q
M
S
C
N
P
A
I
G
G
I
G
----
K
G
H
L
V
K
E
V
----
D
A
L
G
G
L
M
A
K
A
I
D
Q
A
G
I
Q
F
R
I
L
N
A
S
K
G
P
A
V
R
A
---
T
R
A
---
Q
A
D
R
V
L
Y
R
Q
A
V
R
T
A
L
E
N
Q
P
N
L
M
I
F
Q
Q
-
A
V
E
D
L
I
V
E
N
D
R
-----
V
V
G
A
V
T
Q
M
G
L
K
F
R
A
K
A
V
V
L
T
V
G
T
F
L
D
G
K
I
H
I
G
--------------
S
I
P
-
L
S
R
R
L
R
E
-
L
P
L
R
V
G
R
L
K
-
T
G
T
P
----------
P
R
I
D
A
R
T
I
D
F
-------
S
V
L
A
Q
Q
H
G
D
N
P
M
P
V
F
S
F
M
G
N
A
-
S
-
Q
-------
H
P
Q
Q
V
P
C
Y
I
T
H
T
N
-
E
K
T
H
-
D
V
I
R
S
N
L
D
R
S
---------------------
P
S
I
E
D
K
V
M
R
------
F
A
--------
D
----
R
N
-
Q
H
Q
I
F
L
E
P
E
G
L
T
S
N
E
I
Y
P
N
G
I
S
T
S
L
P
F
D
V
Q
M
Q
I
V
R
S
----------
M
Q
G
M
E
N
A
K
I
V
R
P
G
Y
A
I
E
Y
D
F
F
D
-
P
R
D
L
K
P
-
T
L
E
S
K
F
I
Q
G
L
F
F
A
G
Q
I
N
G
---
T
T
-
G
Y
E
--
E
A
A
A
Q
G
L
L
A
G
L
N
A
A
-
R
L
S
A
D
K
E
G
W
A
P
A
R
S
Q
A
Y
L
G
V
L
V
D
D
L
C
T
L
G
T
K
E
P
Y
R
M
F
T
S
R
A
E
Y
R
L
M
L
R
E
D
N
A
D
L
R
L
T
E
I
G
R
E
L
G
L
V
D
D
E
--
R
W
A
R
F
N
E
K
L
E
N
I
E
R
E
R
Q
R
L
K
S
T
W
V
T
P
SA
E
A
A
A
E
V
N
A
H
L
--
T
---
A
P
L
S
R
E
A
S
-----
G
E
D
L
L
R
R
P
E
M
T
Y
E
K
L
T
T
L
T
P
F
A
P
A
L
T
--
D
E
Q
A
A
E
Q
V
E
I
Q
V
----------------------------------------------
K
Y
E
G
---------------------------------------------------------------------------------
26
PsiBlast_CBE
76.00
40%
-71
- C6 -
3CP8
1
MNMG_CHLTE
D:
[20-580]
-
H
M
Y
D
V
I
V
V
G
A
G
H
A
G
C
E
A
A
L
A
V
A
R
G
G
L
H
C
L
L
I
T
S
D
L
S
A
V
A
---------
R
M
S
C
N
P
A
I
G
G
V
A
----
K
G
Q
I
T
R
E
I
----
D
A
L
G
G
E
M
G
K
A
I
D
A
T
G
I
Q
F
R
M
L
N
R
S
K
G
P
A
M
H
S
---
P
R
A
---
Q
A
D
K
T
Q
Y
S
L
Y
M
R
R
I
V
E
H
E
P
N
I
D
L
L
Q
D
-
T
V
--
I
G
V
S
A
N
S
G
---
K
F
S
S
V
T
V
R
S
G
R
A
I
Q
A
K
A
A
I
L
A
C
G
T
F
L
N
G
L
I
H
I
G
M
D
H
F
P
G
G
R
S
-
T
A
E
P
P
V
E
G
L
T
E
S
L
A
S
-
L
G
F
S
F
G
R
L
K
-
T
G
T
P
----------
P
R
I
D
S
R
S
V
D
Y
-------
T
I
V
T
E
Q
P
G
D
V
D
P
V
P
F
S
F
S
S
T
S
-
V
A
N
-------
R
N
L
-
V
S
C
Y
L
T
K
T
T
-
E
K
T
H
-
D
I
L
R
T
G
F
D
R
S
P
-
L
-
F
-
T
G
------------
C
P
S
I
E
D
K
I
S
R
------
F
P
--------
D
----
K
S
-
S
H
H
I
F
L
E
P
E
G
T
D
T
V
E
M
Y
V
N
G
F
S
T
S
L
P
E
D
I
Q
I
A
G
L
R
S
----------
I
P
G
L
E
E
A
K
M
I
R
P
G
Y
A
I
E
Y
D
F
F
H
-
P
W
Q
I
R
S
-
T
M
E
T
R
P
V
E
N
L
F
F
A
G
Q
I
N
G
---
T
S
-
G
Y
E
--
E
A
A
A
Q
G
L
M
A
G
I
N
-
A
V
R
K
I
L
G
K
E
L
I
V
L
G
R
D
Q
A
Y
I
G
V
L
I
D
D
L
I
T
K
E
T
K
E
P
Y
R
M
F
T
S
S
A
E
H
R
L
I
L
R
H
D
N
A
D
L
R
L
R
K
I
G
Y
D
C
N
L
V
S
S
D
--
D
L
H
R
T
E
S
I
I
K
R
V
Q
H
C
L
E
V
M
K
T
A
K
V
T
P
--
A
E
I
N
T
L
---
L
--
M
---
N
K
G
L
Q
E
-
L
KTPAR
A
L
S
L
I
K
R
P
G
I
---
S
L
Q
D
I
L
-------------------------------
E
H
S
L
S
V
R
S
A
A
E
E
L
C
N
D
P
R
---------
V
A
E
Q
V
Q
I
E
I
K
Y
E
G
Y
I
K
R
E
Q
L
V
A
D
-----------------------------------------------------------------------
3
PsiBlast_PDB
75.68
48%
-64
- C6 -
3G05
3
MNMG_ECO57
A:
[33-572]
---
F
D
V
I
I
I
G
G
G
H
A
G
T
E
A
A
M
A
A
A
R
M
G
Q
Q
T
L
L
L
T
H
N
I
D
T
L
G
---------
Q
M
S
C
N
P
A
I
G
G
I
G
----
K
G
H
L
V
K
E
V
----
D
A
L
G
G
L
M
A
K
A
I
D
Q
A
G
I
Q
F
R
I
L
N
A
S
K
G
P
A
V
R
A
---
T
R
A
---
Q
A
D
R
V
L
Y
R
Q
A
V
R
T
A
L
E
N
Q
P
N
L
M
I
F
Q
Q
-
A
V
E
D
L
I
V
E
N
D
R
-----
V
V
G
A
V
T
Q
M
G
L
K
F
R
A
K
A
V
V
L
T
V
G
T
F
L
D
G
K
I
H
I
G
L
D
------------
S
I
P
-
L
S
R
R
L
R
E
-
L
P
L
R
V
G
R
L
K
-
T
G
T
P
----------
P
R
I
D
A
R
T
I
D
F
-------
S
V
L
A
Q
Q
H
G
D
N
P
M
P
V
F
S
F
M
G
N
A
-
S
-
Q
-------
H
P
Q
Q
V
P
C
Y
I
T
H
T
N
-
E
K
T
H
-
D
V
I
R
S
N
L
D
R
S
--
P
------------------
P
S
I
E
D
K
V
M
R
------
F
A
--------
D
----
R
N
-
Q
H
Q
I
F
L
E
P
E
G
L
T
S
N
E
I
Y
P
N
G
I
S
T
S
L
P
F
D
V
Q
M
Q
I
V
R
S
----------
M
Q
G
M
E
N
A
K
I
V
R
P
G
Y
A
I
E
Y
D
F
F
D
-
P
R
D
L
K
P
-
T
L
E
S
K
F
I
Q
G
L
F
F
A
G
Q
I
N
G
---
T
T
-
G
Y
E
--
E
A
A
A
Q
G
L
L
A
G
L
N
A
A
-
R
L
S
D
D
K
E
G
W
A
P
A
R
S
Q
A
Y
L
G
V
L
V
D
D
L
C
T
L
G
T
K
E
P
Y
R
M
F
T
S
R
A
E
Y
R
L
M
L
R
E
D
N
A
D
L
R
L
T
E
I
G
R
E
L
G
L
V
D
D
E
--
R
W
A
R
F
N
E
K
L
E
N
I
E
R
E
R
Q
R
L
K
S
T
W
V
T
P
SA
E
A
A
A
E
V
N
A
H
L
--
T
---
A
P
L
S
R
E
A
S
-----
G
E
D
L
L
R
R
P
E
M
T
Y
E
K
L
T
T
L
T
P
F
A
P
A
L
T
--
D
E
Q
A
A
E
Q
V
E
I
Q
V
K
Y
E
G
-------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
75.05
45%
-73
- C6 -
3CP2
1
MNMG_ECOLI
A:
[27-573]
---
F
D
V
I
I
I
G
G
G
H
A
G
T
E
A
A
M
A
A
A
R
M
G
Q
Q
T
L
L
L
T
H
N
I
D
T
L
G
---------
Q
M
S
C
N
P
A
I
G
G
I
G
----
K
G
H
L
V
K
E
V
----
D
A
L
G
G
L
M
A
K
A
I
D
Q
A
G
I
Q
F
R
I
L
N
A
S
K
G
P
A
V
R
A
---
T
R
A
---
Q
A
D
R
V
L
Y
R
Q
A
V
R
T
A
L
E
N
Q
P
N
L
M
I
F
Q
Q
-
A
V
E
D
L
I
V
E
N
D
R
-----
V
V
G
A
V
T
Q
M
G
L
K
F
R
A
K
A
V
V
L
T
V
G
T
F
-----------------------
I
P
-
L
S
R
R
L
R
E
-
L
P
L
R
V
G
R
L
K
-
T
G
T
P
----------
P
R
I
D
A
R
T
I
D
F
-------
S
V
L
A
Q
Q
H
G
D
N
P
M
P
V
F
S
F
M
G
N
A
-
S
-
Q
-------
H
P
Q
Q
V
P
C
Y
I
T
H
T
N
--------------------------------------------------------------
D
----
R
N
-
Q
H
Q
I
F
L
E
P
E
G
L
T
S
N
E
I
Y
P
N
G
I
S
T
S
L
P
F
D
V
Q
M
Q
I
V
R
S
----------
M
Q
G
M
E
N
A
K
I
V
R
P
G
Y
A
I
E
Y
D
F
F
D
-
P
R
D
L
K
P
-
T
L
E
S
K
F
I
Q
G
L
F
F
A
G
Q
I
N
G
---
T
T
-
G
Y
E
--
E
A
A
A
Q
G
L
L
A
G
L
N
A
A
-
R
L
S
A
D
K
E
G
W
A
P
A
R
S
Q
A
Y
L
G
V
L
V
D
D
L
C
T
L
G
T
K
E
P
Y
R
M
F
T
S
R
A
E
Y
R
L
M
L
R
E
D
N
A
D
L
R
L
T
E
I
G
R
E
L
G
L
V
D
D
E
--
R
W
A
R
F
N
E
K
L
E
N
I
E
R
E
R
Q
R
L
K
S
T
W
V
T
P
SA
E
A
A
A
E
V
N
A
H
L
--
T
---
A
P
L
S
R
E
A
S
-----
G
E
D
L
L
R
R
P
E
M
T
Y
E
K
L
T
T
L
T
P
F
A
P
A
L
T
--
D
E
Q
A
A
E
Q
V
E
I
Q
V
----------------------------------------------
K
Y
E
G
Y
I
A
------------------------------------------------------------------------------
21
PsiBlast_CBE
74.94
48%
-64
- C6 -
3G05
3
MNMG_ECO57
B:
[33-572]
---
F
D
V
I
I
I
G
G
G
H
A
G
T
E
A
A
M
A
A
A
R
M
G
Q
Q
T
L
L
L
T
H
N
I
D
T
L
G
---------
Q
M
S
C
N
P
A
I
G
G
I
G
----
K
G
H
L
V
K
E
V
----
D
A
L
G
G
L
M
A
K
A
I
D
Q
A
G
I
Q
F
R
I
L
N
A
S
K
G
P
A
V
R
A
---
T
R
A
---
Q
A
D
R
V
L
Y
R
Q
A
V
R
T
A
L
E
N
Q
P
N
L
M
I
F
Q
Q
-
A
V
E
D
L
I
V
E
N
D
R
-----
V
V
G
A
V
T
Q
M
G
L
K
F
R
A
K
A
V
V
L
T
V
G
T
F
L
D
G
K
I
H
I
G
--------------
S
I
P
-
L
S
R
R
L
R
E
-
L
P
L
R
V
G
R
L
K
-
T
G
T
P
----------
P
R
I
D
A
R
T
I
D
F
-------
S
V
L
A
Q
Q
H
G
D
N
P
M
P
V
F
S
F
M
G
N
A
-
S
-
Q
-------
H
P
Q
Q
V
P
C
Y
I
T
H
T
N
-
E
K
T
H
-
D
V
I
R
S
N
L
D
R
S
---------------------
P
S
I
E
D
K
V
M
R
------
F
A
--------
D
----
R
N
-
Q
H
Q
I
F
L
E
P
E
G
L
T
S
N
E
I
Y
P
N
G
I
S
T
S
L
P
F
D
V
Q
M
Q
I
V
R
S
----------
M
Q
G
M
E
N
A
K
I
V
R
P
G
Y
A
I
E
Y
D
F
F
D
-
P
R
D
L
K
P
-
T
L
E
S
K
F
I
Q
G
L
F
F
A
G
Q
I
N
G
---
T
T
-
G
Y
E
--
E
A
A
A
Q
G
L
L
A
G
L
N
A
A
-
R
L
S
D
D
K
E
G
W
A
P
A
R
S
Q
A
Y
L
G
V
L
V
D
D
L
C
T
L
G
T
K
E
P
Y
R
M
F
T
S
R
A
E
Y
R
L
M
L
R
E
D
N
A
D
L
R
L
T
E
I
G
R
E
L
G
L
V
D
D
E
--
R
W
A
R
F
N
E
K
L
E
N
I
E
R
E
R
Q
R
L
K
S
T
W
V
T
P
SA
E
A
A
A
E
V
N
A
H
L
--
T
---
A
P
L
S
R
E
A
S
-----
G
E
D
L
L
R
R
P
E
M
T
Y
E
K
L
T
T
L
T
P
F
A
P
A
L
T
--
D
E
Q
A
A
E
Q
V
E
I
Q
V
K
Y
E
G
-------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
71.84
54%
-70
- C6 -
2ZXH
4
MNMG_AQUAE
B:
[28-504]
---
F
D
V
V
V
I
G
G
G
H
A
G
I
E
A
A
L
A
A
A
R
M
G
A
K
T
A
M
F
V
L
N
A
D
T
I
G
---------
Q
M
S
C
N
P
A
I
G
G
I
A
----
K
G
I
V
V
R
E
I
----
D
A
L
G
G
E
M
G
K
A
I
D
Q
T
G
I
Q
F
K
M
L
N
T
R
K
G
K
A
V
Q
S
---
P
R
A
---
Q
A
D
K
K
R
Y
R
E
Y
M
K
K
V
C
E
N
Q
E
N
L
Y
I
K
Q
E
-
E
V
V
D
I
I
V
K
N
N
Q
-----
V
V
G
V
R
T
N
L
G
V
E
Y
K
T
K
A
V
V
V
T
T
G
T
F
L
N
G
V
I
Y
I
G
D
K
M
I
P
G
G
R
L
-
G
E
P
R
S
E
G
-
L
S
D
F
Y
R
R
-
F
D
F
P
L
I
R
F
K
-
T
G
T
P
----------
A
R
L
D
K
R
T
I
D
F
-------
S
A
L
E
V
A
P
G
D
D
P
P
P
K
F
S
F
W
T
E
P
-
V
-
G
SYWFPKG
K
E
Q
-
V
N
C
W
I
T
Y
T
T
-
P
K
T
H
-
E
I
I
R
K
N
L
H
R
T
A
L
Y
G
G
-
L
I
-
K
G
I
G
P
----
R
Y
C
P
S
I
E
D
K
I
V
K
------
F
P
--------
D
----
K
E
-
R
H
Q
I
F
L
E
P
E
G
L
D
T
I
E
I
Y
P
N
G
L
S
T
S
L
P
E
E
V
Q
W
E
M
Y
R
S
----------
I
P
G
L
E
N
V
V
L
I
R
P
A
Y
A
I
E
Y
D
V
V
P
-
P
T
E
L
Y
P
-
T
L
E
T
K
K
I
R
G
L
F
H
A
G
N
F
N
G
---
T
T
-
G
Y
E
--
E
A
A
G
Q
G
I
V
A
G
I
N
A
A
L
R
A
F
G
-
K
E
P
I
Y
L
R
R
D
E
S
Y
I
G
V
M
I
D
D
L
T
T
K
G
V
T
E
P
Y
R
L
F
T
S
R
S
E
Y
R
L
Y
I
R
Q
D
N
A
I
L
R
L
A
K
L
G
R
E
L
G
L
L
S
E
E
--
Q
Y
-------
K
L
V
K
E
L
E
R
E
I
E
K
W
K
E
F
Y
--
K
S
E
R
V
R
S
Y
S
V
--
A
---
T
L
M
T
M
N
-
Y
-----
T
L
D
D
V
K
E
K
F
G
Y
E
V
P
Q
H
P
Y
V
K
E
E
V
E
I
Q
L
K
Y
E
P
Y
I
E
R
E
R
K
L
N
E
K
L
K
K
L
E
D
T
K
I
P
P
D
I
D
Y
D
K
I
P
G
L
T
K
E
A
R
E
K
L
K
K
F
K
P
I
T
V
G
Q
A
S
R
I
D
G
I
T
P
A
A
I
T
A
L
L
V
Y
L
G
----------------------------------------------------------------------
4
PsiBlast_PDB
71.83
54%
-69
- C6 -
2ZXH
3
MNMG_AQUAE
A:
[28-504]
---
F
D
V
V
V
I
G
G
G
H
A
G
I
E
A
A
L
A
A
A
R
M
G
A
K
T
A
M
F
V
L
N
A
D
T
I
G
---------
Q
M
S
C
N
P
A
I
G
G
I
A
----
K
G
I
V
V
R
E
I
----
D
A
L
G
G
E
M
G
K
A
I
D
Q
T
G
I
Q
F
K
M
L
N
T
R
K
G
K
A
V
Q
S
---
P
R
A
---
Q
A
D
K
K
R
Y
R
E
Y
M
K
K
V
C
E
N
Q
E
N
L
Y
I
K
Q
E
-
E
V
V
D
I
I
V
K
N
N
Q
-----
V
V
G
V
R
T
N
L
G
V
E
Y
K
T
K
A
V
V
V
T
T
G
T
F
L
N
G
V
I
Y
I
G
D
K
M
I
P
G
G
R
L
-
G
E
P
R
S
E
G
-
L
S
D
F
Y
R
R
-
F
D
F
P
L
I
R
F
K
-
T
G
T
P
----------
A
R
L
D
K
R
T
I
D
F
-------
S
A
L
E
V
A
P
G
D
D
P
P
P
K
F
S
F
W
T
E
P
-
V
-
G
SYWFPKG
K
E
Q
-
V
N
C
W
I
T
Y
T
T
-
P
K
T
H
-
E
I
I
R
K
N
L
H
R
T
A
L
Y
G
G
-
L
I
-
K
G
I
G
P
----
R
Y
C
P
S
I
E
D
K
I
V
K
------
F
P
--------
D
----
K
E
-
R
H
Q
I
F
L
E
P
E
G
L
D
T
I
E
I
Y
P
N
G
L
S
T
S
L
P
E
E
V
Q
W
E
M
Y
R
S
----------
I
P
G
L
E
N
V
V
L
I
R
P
A
Y
A
I
E
Y
D
V
V
P
-
P
T
E
L
Y
P
-
T
L
E
T
K
K
I
R
G
L
F
H
A
G
N
F
N
G
---
T
T
-
G
Y
E
--
E
A
A
G
Q
G
I
V
A
G
I
N
A
A
L
R
A
F
G
-
K
E
P
I
Y
L
R
R
D
E
S
Y
I
G
V
M
I
D
D
L
T
T
K
G
V
T
E
P
Y
R
L
F
T
S
R
S
E
Y
R
L
Y
I
R
Q
D
N
A
I
L
R
L
A
K
L
G
R
E
L
G
L
L
S
E
E
--
Q
Y
-------
K
L
V
K
E
L
E
R
E
I
E
K
W
K
E
F
Y
--
K
S
E
R
V
R
S
Y
S
V
--
A
---
T
L
M
T
M
N
-
Y
-----
T
L
D
D
V
K
E
K
F
G
Y
E
V
P
Q
H
P
Y
V
K
E
E
V
E
I
Q
L
K
Y
E
P
Y
I
E
R
E
R
K
L
N
E
K
L
K
K
L
E
D
T
K
I
P
P
D
I
D
Y
D
K
I
P
G
L
T
K
E
A
R
E
K
L
K
K
F
K
P
I
T
V
G
Q
A
S
R
I
D
G
I
T
P
A
A
I
T
A
L
L
V
Y
L
G
K
L
--------------------------------------------------------------------
24
PsiBlast_CBE
71.03
54%
-74
- C6 -
2ZXI
1
MNMG_AQUAE
B:
[28-504]
---
F
D
V
V
V
I
G
G
G
H
A
G
I
E
A
A
L
A
A
A
R
M
G
A
K
T
A
M
F
V
L
N
A
D
T
I
G
---------
Q
M
S
C
N
P
A
I
G
G
I
A
----
K
G
I
V
V
R
E
I
----
D
A
L
G
G
E
M
G
K
A
I
D
Q
T
G
I
Q
F
K
M
L
N
T
R
K
G
K
A
V
Q
S
---
P
R
A
---
Q
A
D
K
K
R
Y
R
E
Y
M
K
K
V
C
E
N
Q
E
N
L
Y
I
K
Q
E
-
E
V
V
D
I
I
V
K
N
N
Q
-----
V
V
G
V
R
T
N
L
G
V
E
Y
K
T
K
A
V
V
V
T
T
G
T
F
L
N
G
V
I
Y
I
G
D
K
M
I
P
G
G
R
L
-
G
E
P
R
S
E
G
-
L
S
D
F
Y
R
R
-
F
D
F
P
L
I
R
F
K
-
T
G
T
P
----------
A
R
L
D
K
R
T
I
D
F
-------
S
A
L
E
V
A
P
G
D
D
P
P
P
K
F
S
F
W
T
E
P
-
V
-
G
SYWFPKG
K
E
Q
-
V
N
C
W
I
T
Y
T
T
-
P
K
T
H
-
E
I
I
R
K
N
L
H
R
T
A
-----------------
R
Y
C
P
S
I
E
D
K
I
V
K
------
F
P
--------
D
----
K
E
-
R
H
Q
I
F
L
E
P
E
G
L
D
T
I
E
I
Y
P
N
G
L
S
T
S
L
P
E
E
V
Q
W
E
M
Y
R
S
----------
I
P
G
L
E
N
V
V
L
I
R
P
A
Y
A
I
E
Y
D
V
V
P
-
P
T
E
L
Y
P
-
T
L
E
T
K
K
I
R
G
L
F
H
A
G
N
F
N
G
---
T
T
-
G
Y
E
--
E
A
A
G
Q
G
I
V
A
G
I
N
A
A
L
R
A
F
G
-
K
E
P
I
Y
L
R
R
D
E
S
Y
I
G
V
M
I
D
D
L
T
T
K
G
V
T
E
P
Y
R
L
F
T
S
R
S
E
Y
R
L
Y
I
R
Q
D
N
A
I
L
R
L
A
K
L
G
R
E
L
G
L
L
S
E
E
--
Q
Y
-------
K
L
V
K
E
L
E
R
E
I
E
K
W
K
E
F
Y
--
K
S
E
R
V
S
V
A
V
G
--
G
---
D
T
R
S
Y
S
-
V
-----
A
T
L
M
T
M
N
Y
T
L
D
D
V
K
E
K
F
G
Y
E
V
P
Q
H
P
Y
V
K
E
E
V
E
I
Q
L
K
Y
E
P
Y
I
E
R
E
R
K
L
N
E
K
L
K
K
L
E
D
T
K
I
P
P
D
I
D
Y
D
K
I
P
G
L
T
K
E
A
R
E
K
L
K
K
F
K
P
I
T
V
G
Q
A
S
R
I
D
G
I
T
P
A
A
I
T
A
L
L
V
Y
L
G
K
-------------------------------------------------------------
22
PsiBlast_CBE
70.93
54%
-73
- C6 -
2ZXI
1
MNMG_AQUAE
D:
[28-504]
---
F
D
V
V
V
I
G
G
G
H
A
G
I
E
A
A
L
A
A
A
R
M
G
A
K
T
A
M
F
V
L
N
A
D
T
I
G
---------
Q
M
S
C
N
P
A
I
G
G
I
A
----
K
G
I
V
V
R
E
I
----
D
A
L
G
G
E
M
G
K
A
I
D
Q
T
G
I
Q
F
K
M
L
N
T
R
K
G
K
A
V
Q
S
---
P
R
A
---
Q
A
D
K
K
R
Y
R
E
Y
M
K
K
V
C
E
N
Q
E
N
L
Y
I
K
Q
E
-
E
V
V
D
I
I
V
K
N
N
Q
-----
V
V
G
V
R
T
N
L
G
V
E
Y
K
T
K
A
V
V
V
T
T
G
T
F
L
N
G
V
I
Y
I
G
D
K
M
I
P
G
G
R
L
-
G
E
P
R
S
E
G
-
L
S
D
F
Y
R
R
-
F
D
F
P
L
I
R
F
K
-
T
G
T
P
----------
A
R
L
D
K
R
T
I
D
F
-------
S
A
L
E
V
A
P
G
D
D
P
P
P
K
F
S
F
W
T
E
P
-
V
-
G
SYWFPKG
K
E
Q
-
V
N
C
W
I
T
Y
T
T
-
P
K
T
H
-
E
I
I
R
K
N
L
H
R
--------------------
Y
C
P
S
I
E
D
K
I
V
K
------
F
P
--------
D
----
K
E
-
R
H
Q
I
F
L
E
P
E
G
L
D
T
I
E
I
Y
P
N
G
L
S
T
S
L
P
E
E
V
Q
W
E
M
Y
R
S
----------
I
P
G
L
E
N
V
V
L
I
R
P
A
Y
A
I
E
Y
D
V
V
P
-
P
T
E
L
Y
P
-
T
L
E
T
K
K
I
R
G
L
F
H
A
G
N
F
N
G
---
T
T
-
G
Y
E
--
E
A
A
G
Q
G
I
V
A
G
I
N
A
A
L
R
A
F
G
-
K
E
P
I
Y
L
R
R
D
E
S
Y
I
G
V
M
I
D
D
L
T
T
K
G
V
T
E
P
Y
R
L
F
T
S
R
S
E
Y
R
L
Y
I
R
Q
D
N
A
I
L
R
L
A
K
L
G
R
E
L
G
L
L
S
E
E
--
Q
Y
-------
K
L
V
K
E
L
E
R
E
I
E
K
W
K
E
F
Y
--
K
S
E
R
V
S
V
A
V
G
--
G
---
D
T
R
S
Y
S
-
V
-----
A
T
L
M
T
M
N
Y
T
L
D
D
V
K
E
K
F
G
Y
E
V
P
Q
H
P
Y
V
K
E
E
V
E
I
Q
L
K
Y
E
P
Y
I
E
R
E
R
K
L
N
E
K
L
K
K
L
E
D
T
K
I
P
P
D
I
D
Y
D
K
I
P
G
L
T
K
E
A
R
E
K
L
K
K
F
K
P
I
T
V
G
Q
A
S
R
I
D
G
I
T
P
A
A
I
T
A
L
L
V
Y
L
G
K
-------------------------------------------------------------
23
PsiBlast_CBE
70.67
54%
-74
- C6 -
2ZXI
1
MNMG_AQUAE
C:
[28-504]
---
F
D
V
V
V
I
G
G
G
H
A
G
I
E
A
A
L
A
A
A
R
M
G
A
K
T
A
M
F
V
L
N
A
D
T
I
G
---------
Q
M
S
C
N
P
A
I
G
G
I
A
----
K
G
I
V
V
R
E
I
----
D
A
L
G
G
E
M
G
K
A
I
D
Q
T
G
I
Q
F
K
M
L
N
T
R
K
G
K
A
V
Q
S
---
P
R
A
---
Q
A
D
K
K
R
Y
R
E
Y
M
K
K
V
C
E
N
Q
E
N
L
Y
I
K
Q
E
-
E
V
V
D
I
I
V
K
N
N
Q
-----
V
V
G
V
R
T
N
L
G
V
E
Y
K
T
K
A
V
V
V
T
T
G
T
F
L
N
G
V
I
Y
I
G
D
K
M
I
P
G
G
R
L
-
G
E
P
R
S
E
G
-
L
S
D
F
Y
R
R
-
F
D
F
P
L
I
R
F
K
-
T
G
T
P
----------
A
R
L
D
K
R
T
I
D
F
-------
S
A
L
E
V
A
P
G
D
D
P
P
P
K
F
S
F
W
T
E
P
-
V
-
G
SYWFPKG
K
E
Q
-
V
N
C
W
I
T
Y
T
T
-
P
K
T
H
-
E
I
I
R
K
N
L
H
R
T
A
-----------------
R
Y
C
P
S
I
E
D
K
I
V
K
------
F
P
--------
D
----
K
E
-
R
H
Q
I
F
L
E
P
E
G
L
D
T
I
E
I
Y
P
N
G
L
S
T
S
L
P
E
E
V
Q
W
E
M
Y
R
S
----------
I
P
G
L
E
N
V
V
L
I
R
P
A
Y
A
I
E
Y
D
V
V
P
-
P
T
E
L
Y
P
-
T
L
E
T
K
K
I
R
G
L
F
H
A
G
N
F
N
G
---
T
T
-
G
Y
E
--
E
A
A
G
Q
G
I
V
A
G
I
N
A
A
L
R
A
F
G
-
K
E
P
I
Y
L
R
R
D
E
S
Y
I
G
V
M
I
D
D
L
T
T
K
G
V
T
E
P
Y
R
L
F
T
S
R
S
E
Y
R
L
Y
I
R
Q
D
N
A
I
L
R
L
A
K
L
G
R
E
L
G
L
L
S
E
E
--
Q
Y
-------
K
L
V
K
E
L
E
R
E
I
E
K
W
K
E
F
Y
--
K
S
E
R
V
S
V
A
V
G
--
T
---
R
S
Y
S
V
A
-
T
-----
L
M
T
M
N
Y
T
L
D
D
V
K
E
K
F
G
Y
E
V
P
Q
H
P
Y
V
K
E
E
V
E
I
Q
L
K
Y
E
P
Y
I
E
R
E
R
K
L
N
E
K
L
K
K
L
E
D
T
K
I
P
P
D
I
D
Y
D
K
I
P
G
L
T
K
E
A
R
E
K
L
K
K
F
K
P
I
T
V
G
Q
A
S
R
I
D
G
I
T
P
A
A
I
T
A
L
L
V
Y
L
G
K
---------------------------------------------------------------
65
HHSearch
48.93
25%
-61
- C5 -
3G5S
8
TRMFO_THET8
A:
[1-427]
--
M
E
R
V
N
V
V
G
A
G
L
A
G
S
E
A
A
W
T
L
L
R
L
G
V
P
V
R
L
F
E
M
R
P
K
R
M
T
PAHGTDRFA
E
I
V
C
S
N
S
L
G
G
E
G
ETN
A
K
G
L
L
Q
A
E
M
----
R
R
A
G
S
L
V
M
E
A
A
D
L
A
R
-----
V
-----
P
A
--
G
---
G
A
L
---
A
V
D
R
E
E
F
S
G
Y
I
T
E
R
L
T
G
H
------------------------
P
L
L
E
V
V
R
E
E
V
R
E
I
P
P
G
I
T
V
L
A
T
G
P
L
T
S
---------------------
E
A
-
L
A
E
A
L
K
R
R
F
G
D
H
F
L
A
Y
Y
-
D
A
A
S
----------
P
I
V
L
Y
E
S
I
D
L
-------
T
K
C
F
R
A
G
R
Y
-------------------------
Y
-
L
N
C
P
M
T
E
E
E
Y
R
R
F
H
-
Q
A
L
L
E
A
Q
R
H
T
P
H-----------
F
----
E
A
C
V
P
V
E
E
L
A
R
R
GYQ
T
L
L
F
G
PMKPVGLV
D
PRTG
K
E
P
F
A
V
V
Q
L
R
Q
E
D
K
A
G
R
M
W
S
L
V
G
F
Q
T
G
L
K
W
P
E
Q
K
R
L
I
Q
M
----------
I
P
G
L
E
N
A
E
I
V
R
Y
G
V
M
H
R
N
T
Y
L
N
A
P
R
L
L
G
E
-
T
L
E
F
R
E
A
E
G
L
Y
A
A
G
V
L
A
G
---
V
E
-
G
Y
L
--
E
S
A
A
T
G
F
L
A
G
L
N
A
A
R
K
A
L
-
G
L
P
P
V
A
P
-
P
E
E
S
M
L
G
G
L
V
R
Y
L
A
T
A
N
P
E
G
F
Q
P
M
-----------------------
Y
A
N
W
G
L
V
P
P
V
EG
R
M
G
K
K
E
K
R
Q
A
M
Y
R
R
G
L
E
A
F
S
A
W
L
S
G
L
--
N
P
P
L
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
HHSearch
38.76
37%
-124
- C6 -
2BS2
1
FRDA_WOLSU
A:
[4-38]
-
Q
Y
C
D
S
L
V
I
G
G
G
L
A
G
L
R
A
A
V
A
T
Q
Q
K
G
L
S
T
I
V
L
S
L
I
P
V
K
R
S
---------
H
S
A
A
A
Q
G
G
M
Q
A
S
----
L
G
N
S
K
M
S
D
----
G
D
N
E
D
L
H
F
M
D
T
V
K
G
S
D
W
G
C
D
Q
K
V
A
R
M
F
V
N
T
A
---
P
K
A
---
I
R
E
L
A
A
W
G
V
P
W
T
R
I
H
K
G
D
R
M
A
I
I
N
A
Q
-
K
T
T
I
T
E
E
D
F
R
H
G
L
I
H
S
R
D
F
G
G
T
K
K
W
R
T
C
Y
T
A
D
A
T
G
H
T
M
L
F
A
V
A
N
E
C
L
K
L
G
V
S
I
Q
D
R
K
-
E
A
I
A
L
I
H
-
Q
D
G
K
C
Y
G
-
A
V
V
R
D
L
V
T
G
-
D
I
I
A
----------
Y
V
A
K
G
T
L
I
A
T
-------
G
G
Y
G
R
I
Y
K
N
T
T
N
A
V
V
C
E
G
T
G
T
-
A
-
I
-------
A
L
E
-
T
G
I
A
Q
L
G
N
M
-
E
A
V
Q
-
F
H
P
T
P
L
F
P
S
G
I
-
L
L
T
-
E
G
-
C
R
G
D
G
----
G
I
L
R
D
V
D
G
H
R
F
M
------
P
D
--------
Y
----
E
P
-
E
K
K
E
L
A
S
R
D
V
V
S
R
R
M
I
E
H
I
R
K
G
K
G
V
Q
S
P
Y
G
Q
H
L
W
L
D
----------
I
S
I
L
G
R
K
H
I
E
T
N
L
R
D
V
Q
E
I
C
E
Y
-
F
A
G
I
D
P
-
A
E
K
W
A
P
V
L
P
M
Q
H
Y
S
M
G
G
I
---
R
T
-
D
Y
R
--
G
E
A
K
L
K
G
L
F
S
A
G
E
A
A
C
W
D
M
H
G
F
N
R
L
G
G
N
S
V
S
E
A
V
V
A
G
M
I
V
G
E
Y
F
A
E
H
C
A
N
T
Q
V
D
L
E
T
K
T
L
E
K
F
V
K
G
Q
E
A
Y
M
K
S
L
V
E
S
K
G
T
E
D
V
F
--
K
I
K
N
R
M
K
D
V
M
D
D
N
V
G
I
F
R
D
G
P
H
L
E
K
A
--
V
K
E
L
E
E
L
Y
K
K
--
S
---
K
N
V
G
I
K
-
N
-----
K
R
L
H
A
N
P
E
L
E
E
A
Y
R
V
P
M
M
L
K
V
A
L
C
V
A
K
G
A
L
D
R
T
E
S
R
G
A
H
N
R
E
D
Y
P
K
R
D
D
I
N
W
L
N
R
T
L
A
S
W
P
N
P
E
Q
T
L
P
T
L
E
Y
E
A
L
D
V
N
E
M
E
I
A
P
G
Y
R
G
Y
G
A
K
G
N
Y
I
E
N
P
L
S
V
K
R
Q
E
E
I
D
K
I
Q
S
E
L
E
A
A
G
K
D
R
H
A
I
Q
E
A
L
M
P
Y
E
L
P
A
K
Y
K
A
R
N
E
R
L
G
D
K
-----------------------
75
HHSearch
37.18
40%
-102
- C6 -
2H88
1
SDHA_CHICK
A:
[17-51]
-
H
E
F
D
A
V
V
V
G
A
G
G
A
G
L
R
A
A
F
G
L
S
E
A
G
F
N
T
A
C
V
T
K
L
F
P
T
R
S
---------
H
T
V
A
A
Q
G
G
I
N
A
A
----
L
G
N
M
E
D
D
N
----
W
R
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
D
A
I
H
Y
M
T
E
Q
A
P
A
A
---
V
I
E
---
L
E
N
Y
G
M
P
F
S
R
T
E
E
G
K
I
Y
Q
R
A
F
G
G
Q
S
L
-
Q
F
G
K
G
G
Q
A
H
R
C
C
C
V
A
D
R
T
G
H
S
L
L
H
T
L
Y
G
R
S
L
R
Y
D
T
S
Y
F
V
E
Y
F
A
L
D
L
L
M
E
N
G
E
C
R
G
V
I
-
A
L
C
I
E
D
G
-
T
I
H
R
F
R
A
-
K
N
T
V
I
A
T
G
G
-
Y
G
R
T
----------
Y
F
S
C
T
S
A
H
T
S
-------
T
G
D
G
T
A
M
V
T
R
A
G
L
P
C
Q
D
L
E
F
V
-
Q
-
F
-------
H
P
T
-
G
I
Y
G
A
G
C
L
I
-
T
E
G
C
-
R
G
E
G
G
I
L
I
N
S
Q
-
G
E
R
-
F
M
-
E
R
Y
A
P
----
V
A
K
D
L
A
S
R
D
V
V
S
------
R
S
--------
M
----
T
I
-
E
I
R
E
G
R
G
C
G
P
E
K
D
H
V
Y
L
Q
L
H
H
L
P
P
Q
Q
L
A
T
R
L
P
G
I
S
E
----------
T
A
M
I
F
A
G
V
D
V
T
K
E
P
I
P
V
L
P
T
V
H
-
Y
N
M
G
G
I
-
P
T
N
Y
K
G
Q
V
I
T
H
V
N
G
E
D
K
V
---
V
P
-
G
L
Y
--
A
C
G
E
A
A
S
A
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
L
V
V
F
G
R
A
C
A
L
T
I
A
E
T
C
K
P
G
E
P
V
P
S
I
K
P
N
A
G
E
E
S
V
A
N
L
D
K
L
R
F
A
D
G
T
I
R
T
S
E
A
R
L
N
M
Q
K
T
M
Q
--
S
H
A
A
V
F
R
T
G
S
I
L
Q
E
G
C
E
K
L
S
Q
I
Y
R
D
L
--
A
H
L
K
T
F
D
R
G
I
--
V
---
W
N
T
D
L
V
-
E
-----
T
L
E
L
Q
N
L
M
L
C
A
L
Q
T
I
Y
G
A
E
A
R
K
E
S
R
G
A
H
A
R
E
D
Y
K
L
R
I
D
E
F
D
Y
S
K
P
L
Q
G
Q
Q
K
R
P
F
E
E
H
W
R
K
H
T
L
S
Y
V
D
V
K
S
G
K
V
T
L
K
Y
R
P
V
I
D
R
T
L
N
E
E
D
C
S
S
V
P
P
A
I
R
S
Y
-----------------------------------------------------------------------
67
HHSearch
36.91
21%
-51
* C5 *
2I0Z
2
?
A:
[25-444]
-
M
H
Y
D
V
I
V
I
G
G
G
P
S
G
L
M
A
A
I
G
A
A
E
E
G
A
N
V
L
L
L
D
K
G
N
K
L
G
R
K
L
A
I
SG---
G
G
R
C
N
V
T
N
R
L
P
-----
L
D
E
I
V
K
H
I
PGNG
R
F
L
Y
S
A
F
S
I
F
N
N
E
D
I
--
I
T
F
F
E
-
N
L
G
V
K
L
K
E
E
D
H
G
R
M
F
P
V
S
N
K
A
Q
S
V
V
D
A
L
L
T
R
L
K
D
-
L
G
V
K
I
R
T
N
T
P
V
E
T
I
E
Y
E
N
G
-----
Q
T
K
A
V
I
L
Q
T
G
E
V
L
E
T
N
H
V
V
I
A
V
G
G
K
S
V
P
Q
---------
T
G
S
T
-
G
D
--
G
Y
A
-
W
A
E
---
K
-
A
G
H
T
I
T
E
L
F
P
T
E
V
P
I
L
S
NE
P
F
I
R
D
R
S
L
Q
G
L
A
L
R
D
I
N
L
S
VLN-
A
I
I
S
H
K
M
D
M
L
F
T
H
F
G
L
S
--
G
-
P
-
A
-------
A
L
R
-
C
S
Q
F
V
V
K
A
L
-
K
K
F
K
T
N
T
I
Q
M
S
I
D
A
L
P
E
E
N
S
E
Q
L
F
Q
R
M
L
K
Q
M
K
E
D
P
K
K
G
I
K
N
V
L
K
G
------
Y
V
--------
P
----
E
R
-
Y
F
L
F
L
L
E
K
N
E
I
D
G
-----
S
E
Q
A
G
Q
V
S
H
E
K
I
R
A
L
V
K
D
F
K
E
F
T
V
N
V
N
G
T
Q
S
I
E
K
A
F
V
T
G
G
G
-------
V
S
-
V
K
E
I
N
P
K
E
M
S
S
K
F
T
N
G
L
Y
F
C
G
E
V
L
D
I
H
G
Y
T
G
G
Y
N
I
T
S
A
L
V
T
G
R
I
A
G
T
T
A
G
E
N
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
35.17
51%
-81
- C6 -
4M52
2
DLDH_MYCTU
A:
[3-37]
M
T
H
Y
D
V
V
V
L
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
S
T
A
I
V
E
P
K
Y
W
G
G
V
---------
C
L
N
V
G
C
I
P
S
K
A
L
----
L
R
N
A
E
L
V
H
----
I
F
T
K
D
A
K
A
F
G
I
S
G
E
V
T
F
D
Y
G
I
A
Y
D
R
S
R
K
V
A
E
---
G
R
V
---
A
G
V
H
F
L
M
K
K
N
K
I
T
E
I
H
G
Y
G
T
F
A
D
A
N
T
-
L
L
V
D
L
N
D
G
G
T
E
S
V
T
F
D
N
A
I
I
A
T
G
S
S
T
R
L
V
P
G
T
S
L
S
A
N
V
V
T
Y
E
E
Q
I
L
S
R
E
L
P
K
S
I
I
I
A
-
G
A
G
A
I
G
M
-
E
F
G
Y
V
L
K
-
N
Y
G
V
D
V
T
I
V
-
E
F
L
P
----------
R
A
L
P
N
E
D
A
D
V
-------
S
K
E
I
E
K
Q
F
K
K
L
G
V
T
I
L
T
A
T
K
V
-
E
-
S
-------
I
A
D
-
G
G
S
Q
V
T
V
T
V
-
T
K
D
G
-
V
A
Q
E
L
K
A
E
K
V
L
-
Q
A
I
-
G
F
-
A
P
N
V
E
----
G
Y
G
L
D
K
A
G
V
A
L
T
------
D
R
--------
K
----
A
I
-
G
V
D
D
Y
M
R
T
N
V
G
H
I
Y
A
I
G
D
V
N
G
L
L
Q
L
A
H
V
A
E
A
Q
G
V
V
A
----------
A
E
T
I
A
G
A
E
T
L
T
L
G
D
H
R
M
L
P
R
A
T
-
F
C
Q
P
N
V
-
A
S
F
G
L
T
E
Q
Q
A
R
N
E
G
Y
D
V
V
---
V
A
-
K
F
P
--
F
T
A
N
A
K
A
H
G
V
G
D
P
S
G
F
V
K
L
V
A
D
A
K
H
G
E
L
L
G
G
H
L
V
G
H
D
V
A
E
L
L
P
E
L
T
L
A
Q
R
W
D
L
T
A
S
E
L
A
R
N
V
H
T
H
P
T
M
S
E
A
L
Q
E
C
F
H
G
L
V
G
H
M
I
--
N
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------