@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0114: (2016-03-12 )
MQNHTAVNTAQAIILRDLVDALLFEDIAGIVSNSEITKENGQTLLIYERETQQIKIPVYFSALNMFRYESSQPITIEGRVSKQPLTAAEFWQTIANMNCDLSHEWEVARVEEGLTTAATQLAKQLSELDLASHPFVMSEQFASLKDRPFHPLAKEKRGLREADYQVYQAELNQSFPLMVAAVKKTHMIHGDTANIDELENLTVPIKEQATDMLNDQGLSIDDYVLFPVHPWQYQHILPNVFATEISEKLVVLLPLKFGDYLSSSSMRSLIDIGAPYNHVKVPFAMQSLGALRLTPTRYMKNGEQAEQLLRQLIEKDEALAKYVMVCDETAWWSYMGQDNDIFKDQLGHLTVQLRKYPEVLAKNDTQQLVSMAALAANDRTLYQMICGKDNISKNDVMTLFEDIAQVFLKVTLSFMQYGALPELHGQNILLSFEDGRVQKCVLRDHDTVRIYKPWLTAHQLSLPKYVVREDTPNTLINEDLETFFAYFQTLAVSVNLYAIIDAIQDLFGVSEHELMSLLKQILKNEVATISWVTTDQLAVRHILFDKQTWPFKQILLPLLYQRDSGGGSMPSGLTTVPNPMVTYD
Atome Classification :
(20 SA)
--------.........10........20........--------30.....----------------...40.-....--.---..-50.-.----......-60........70------....--.....80-........90......--..100.---..-....110-.......120..--------..-----.-----..130.......140.----------......150.......160--.......170......-.180.......190..---.---...-.200.----...--...-210..---.......220.----......230..--------.....-240....--------..-.250.......260.......270...-....280.......290...-....300---.....---....310......---------.-320------.--.-.......330...-....340--..--.----......350.-......360---.------......370.......380--.---....-....-390.........400........410-.-..-....420--.......430.......440..-.-..-..450.......460------.......------.--.470.----.--.-.-..-.480....----...490.......500.......510.......520.---......530.......540.....---------..550......---.560.......570.......580..--------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------MQNHTA
V
N
T
A
Q
A
I
I
L
R
D
L
V
D
A
L
L
F
E
D
I
A
G
--------
I
VSN
S
E
I----------------TKENG
Q
-
T
L
L
I
--
Y
---ER-ET
Q
-
Q
----
I
K
I
P
V
Y
-
F
S
A
L
N
M
F
RYES-------SQ
P
I
--
T
I
EGRVS-KQPL
T
A
A
E
F
W
Q
T
I
A
NM--NCDLSH---EW-
E
V
A
R
V
EE-G
L
T
T
A
A
T
Q
L
A
K
Q
--------
L
S
-----E-----LDLASHP
F
V
M
S
E
Q
F
A
S----------LKDRPFH
P
L
A
K
E
KRGL
R
E
A
--
D
Y
Q
V
Y
Q
A
E
LNQSF
P
L
M
-
V
A
A
V
K
K
T
H
M
IHGDTA
N
---
I
---
D
E
L
-
E
NLTV----
P
I
K
--
E
Q
A
-
T
--
D
M---LNDQGLSID
D
Y
----
V
L
FPVHP
W
Q
Y
Q
--------
H
I
L
P
N
-
V
F
A
T
E
IS--------E
K
-
L
V
V
L
L
PLK
F
G
DYL
S
S
S
S
M
R
S
L
I
DIGAP-YNHVKV
P
F
A
M
Q
SL
G
A
L
RL
T
P
-
T
R
YMK-----
N
G
E
Q
A
---
E
Q
L
L
R
Q
L
I
E
K
D
E
A
---------
L
-
A
--------
K
--
Y
-
V
M
VCDE
T
A
W
W
SYM-GQDND----
I
F
--
K
----
D
Q
L
G
H
L
T
V
Q
L
-
R
K
Y
P
E
V
LAK---N------
D
T
Q
Q
L
V
S
M
A
A
LAAND
R
T
----
L
---
Y
Q
M
I-CGKD-N--ISK
N
D
V
M
T
L
F
E
-
D
I
A
Q
V
F
L
K
V
T
L
-
S
-
F
M
-
Q
YGALPE--LHG
Q
N
I
L
L
S
FEDG
R
V
Q
K
C
V
LRD-H-
D
T
-
V
R
I
Y
KPWL
T
A
HQL--------SL
P
K
Y
V
V------R--EDTP
N
----
T
--
L
-
I
-
N
E
-
D
L
E
T
F
F
A
Y
----
F
Q
T
L
A
V
S
V
N
L
Y
A
I
I
D
A
I
Q
D
L
FGV
S
E
H
E
L
M
S
L
L
K
Q
I
L
K---NEV
A
T
I
S
W
V
T
T
D
Q
L
A
V
R
H
I
LFDKQ---------TW
P
F
K
Q
I
L
L
P
L
---
L
Y
QRDSGGGSMPSGLTTVPNPMVTYD--------------
22
HHSearch
91.70
17%
-80
- C2 -
2X0Q
3
?
A:
[16-601]
---------
L
Q
P
E
I
W
N
K
V
N
R
L
L
V
R
K
A
I
S
E
Y
A
H
E
W
L
L
E
--------
P
Q
R
L
G
P
G
----------------
E
T
P
G
F
E
-
R
F
R
L
--
T
---
L
A
-
D
G
A
-
Q
----
Y
D
F
D
A
Q
-
V
M
A
M
R
H
W
R
I
P
P
-------
E
S
I
V
--
K
T
-
V
A
G
V
-
P
A
P
L
D
A
L
Q
F
V
I
E
I
R
D
K
--
L
G
L
P
-----
V
D
-
R
L
P
I
Y
M
D
-
E
I
T
S
T
L
H
G
S
A
Y
K
--------
H
G
RTTLG
A
-----
A
A
L
A
R
A
D
Y
Q
T
I
E
T
-
S
M
----------
I
E
G
H
P
S
F
V
A
N
N
G
R
L
G
F
D
A
E
--
D
Y
H
G
Y
A
P
E
A
A
T
P
V
R
L
M
-
W
L
A
V
H
K
D
N
A
H
F
S
C
L
S
D
MD
Y
D
---
S
L
M
-
S
E
E
L
G
----
E
S
A
--
V
T
D
F
A
--
A
R
---
L
R
E
Q
G
L
H
P
A
D
Y
----
Y
F
M
P
A
H
P
W
Q
W
F
--------
N
K
L
S
L
-
A
F
A
P
Y
V
A
--------
Q
R
-
K
I
V
C
L
G
Y
G
E
E
Q
Y
L
A
Q
Q
S
I
R
T
F
F
N
I
S
R
P
G
K
R
Y
V
K
T
S
L
S
I
L
N
M
G
F
M
R
G
L
S
-
P
Y
Y
M
A
-----
G
T
P
A
I
---
N
E
Y
I
H
D
L
I
S
A
D
P
W
---------
L
-
R
--------
A
N
-
G
-
F
R
I
L
R
E
V
A
S
M
G
F
R
-
N
Y
Y
Y
E
A
A
I
D
T
D
--
T
----
P
Y
K
K
M
F
S
A
L
W
-
R
E
N
P
L
T
L
I
A
----------
P
G
Q
N
L
M
T
M
A
A
L
L
H
V
D
P
Q
----
G
RA
L
L
P
E
L
-
I
Q
A
S
------
G
L
D
A
G
T
W
L
E
-
R
Y
V
D
A
Y
L
T
P
L
I
-
H
-
C
F
Y
A
H
D
L
V
F
M
--
P
H
G
E
N
V
I
L
V
I
Q
D
G
V
P
V
R
A
F
M
K
D
-
I
-
A
E
E
S
S
I
L
N
P
Q
V
R
L
-------------
P
-------------
Q
A
A
Q
R
-------
L
-
A
-
A
D
V
P
E
A
Y
K
L
L
T
----
I
F
V
D
V
F
E
G
Y
F
R
H
L
T
Q
I
L
V
E
T
E
L
M
P
E
H
D
F
W
R
L
V
A
G
R
I
A
---
A
Y
Q
Q
A
H
P
Q
---
R
L
D
K
Y
R
R
Y
D
L
F
A
P
---------
D
M
I
H
S
C
L
N
R
L
Q
---
L
A
N
------------
P
N
L
P
N
P
I
A
C
F
---------------
23
HHSearch
90.39
18%
-94
- C2 -
3TO3
2
?
A:
[16-595]
----------
E
S
E
D
Y
I
S
V
R
R
R
V
L
R
Q
L
V
E
S
L
I
Y
E
G
I
I
T
--------
P
A
R
I
E
K
E
-------------------
E
Q
I
-
L
F
L
I
--
Q
G
L
D
E
D
N
K
S
V
-
T
----
Y
E
C
Y
G
R
E
R
I
T
F
G
R
I
S
I
D
S
-------
L
-
I
V
--
R
V
-
Q
D
G
K
-
Q
E
I
Q
S
V
A
Q
F
L
E
E
V
F
R
V
--
V
N
V
E
-----
Q
T
-
K
L
D
S
F
I
H
-
E
L
E
Q
T
I
F
K
D
T
I
A
--------
Q
Y
E
RC-------------
K
S
Y
D
E
L
E
N
H
-
L
----------
I
D
G
H
P
Y
H
P
S
Y
K
A
R
I
G
F
Q
Y
R
--
D
N
F
R
Y
G
Y
E
F
M
R
P
I
K
L
I
-
W
I
A
A
H
K
K
N
A
T
V
G
Y
E
N
E
---
V
I
Y
D
K
I
L
-
K
S
E
V
G
----
E
R
K
--
L
E
A
Y
K
--
E
R
---
I
H
S
M
G
C
D
P
K
Q
Y
----
L
F
I
P
V
H
P
W
Q
W
E
--------
N
F
I
I
S
-
N
Y
A
E
D
I
Q
--------
D
K
-
G
I
I
Y
L
G
E
S
A
D
D
Y
C
A
Q
Q
S
M
R
T
L
R
N
V
T
N
P
K
R
P
Y
V
K
V
S
L
N
I
L
N
T
S
T
L
R
T
L
K
-
P
Y
S
V
A
-----
S
A
P
A
I
---
S
N
W
L
S
N
V
V
S
Q
D
S
Y
---------
L
-
R
--------
D
ES
R
-
V
I
L
L
K
E
F
S
S
V
M
Y
D
-
T
N
K
K
--------------
A
T
Y
G
S
L
G
C
I
W
-
R
E
S
V
H
H
Y
L
G
----------
E
Q
E
D
A
V
P
F
N
G
L
Y
A
K
E
K
D
----
G
TPI
I
D
A
W
-
L
N
K
--------
Y
G
I
E
N
W
L
R
-
L
L
I
Q
K
A
I
I
P
V
I
-
H
-
L
V
V
E
H
G
I
A
L
E
--
S
H
G
Q
N
M
I
L
V
H
K
E
G
L
P
V
R
I
A
L
K
D
-
F
H
E
G
-
L
E
F
Y
R
P
F
L
K
E
M
N
K
--------
C
P
D
F
T
K
M
------
H
--
K
T
Y
A
N
GKMN
D
--
F
-
F
E
M
D
-
R
I
E
C
L
Q
E
M
----
V
L
D
A
L
F
L
F
N
V
G
E
L
A
F
V
L
A
D
K
Y
E
W
K
E
E
S
F
W
M
I
V
V
E
E
I
E
---
N
H
F
R
K
Y
P
H
L
---
K
D
R
F
E
S
I
Q
L
Y
T
P
---------
T
F
Y
A
E
Q
L
T
K
R
R
---
L
Y
I
-
D
V
-----
E
S
L
V
H
E
V
P
N
P
L
Y
R
A
---------------
32
Fugue
85.48
16%
-67
- C2 -
2X0O
5
?
A:
[7-601]
PH
P
A
E
I
V
A
H
L
Q
P
E
I
W
N
K
V
N
R
L
L
V
R
K
A
I
S
E
Y
A
H
E
W
L
L
E
--------
P
Q
R
L
G
P
G
----------------
E
T
P
G
F
E
-
R
F
R
L
--
T
---
L
A
-
D
G
A
-
Q
----
Y
D
F
D
A
Q
-
V
M
A
M
R
H
W
R
I
P
P
-------
E
S
I
V
--
K
T
V
A
G
-
V
-
P
A
P
L
D
A
L
Q
F
V
I
E
I
R
D
K
LG
L
P
V
D
R
L
---
P
I
-
Y
M
D
E
I
T
S
-
T
L
H
G
S
A
Y
K
H
G
R
T
--------
T
L
-----
G
-----
A
A
A
L
A
R
A
D
Y
Q
T
I
E
T
S
M
----------
I
E
G
H
P
S
F
V
A
N
N
G
R
L
G
F
D
A
E
--
D
Y
H
G
Y
A
P
E
A
A
T
P
V
R
L
M
-
W
L
A
V
H
K
D
N
A
H
F
S
C
L
S
D
---
M
---
D
Y
D
-
S
L
M
S
E
E
LG
E
S
A
V
--
T
D
F
-
A
--
A
R
---
L
R
E
Q
G
L
H
P
A
D
Y
----
Y
F
M
P
A
H
P
W
Q
W
F
--------
N
K
L
S
L
-
A
F
A
P
Y
V
A
--------
Q
R
-
K
I
V
C
L
G
Y
G
E
E
Q
Y
L
A
Q
Q
S
I
R
T
F
F
N
I
S
R
P
G
K
R
Y
V
K
T
S
L
S
I
L
N
M
G
F
M
R
G
L
S
-
P
Y
Y
M
A
-----
G
T
P
A
I
---
N
E
Y
I
H
D
L
I
S
A
D
P
W
---------
L
-
R
--------
A
--
N
G
F
R
I
L
R
E
V
A
S
M
G
F
R
-
N
Y
Y
Y
E
----
A
A
--
I
DTDT
P
Y
K
K
M
F
S
A
L
W
-
R
E
N
P
L
T
L
I
A
---
P
------
G
-
Q
N
L
M
T
M
A
A
L
L
H
V
D
P
Q
----
G
---
R
A
L
L
-
P
E
L
I
-
Q
--
A
S
G
L
D
A
G
T
W
L
E
-
R
Y
V
D
A
Y
L
T
P
L
I
H
C
-
F
Y
-
A
H
D
L
V
F
M
--
P
H
G
E
N
V
I
L
V
I
Q
D
G
V
P
V
R
A
F
M
K
D
------------
I
A
E
E
S
S
I
--------
L
N
P
Q
V
R
L
------
P
--
Q
A
A
Q
R
----
L
--
A
-
A
-
D
V
-
P
E
A
Y
K
L
L
T
----
I
F
V
D
V
F
E
G
Y
F
R
H
L
T
Q
I
L
V
E
T
E
L
M
P
E
H
D
F
W
R
L
V
A
G
R
I
A
---
A
Y
Q
Q
A
-----
H
P
Q
R
L
D
K
Y
R
R
Y
D
L
F
---------
A
P
D
M
I
H
S
C
L
N
R
---
L
Q
L
A
A
P
----------
N
L
P
N
P
I
A
C
F
---------------
4
PsiBlast_PDB
77.65
20%
-64
- C2 -
3TO3
2
?
A:
[27-471]
---------------------
V
L
R
Q
L
V
E
S
L
I
Y
E
---
G
--------
I
I
T
P
A
R
I
----------------
E
K
E
E
Q
I
-
L
F
L
I
Q
G
L
---
D
E
-
D
N
K
-
S
----
V
T
Y
E
C
Y
-
G
R
E
R
I
T
F
G
R
I
S
-------
I
D
S
L
--
I
V
R
V
Q
D
G
-
K
Q
E
I
------
Q
S
V
A
Q
F
-----
L
E
E
---
V
F
-
R
V
V
N
V
E
Q
T
K
L
D
S
F
I
H
E
L
E
Q
T
--------
I
F
-----
K
-----
D
T
I
A
Q
Y
E
R
C
-------KS
Y
D
E
L
E
N
H
L
I
D
G
H
P
Y
H
P
S
Y
K
A
R
I
G
F
Q
Y
R
--
D
N
F
R
Y
G
Y
E
F
M
R
P
I
K
L
I
W
I
A
A
H
K
K
N
A
T
V
G
Y
E
N
E
V
---
I
Y
--
D
K
I
-
L
K
S
E
V
----
G
E
R
K
L
E
A
Y
-
K
--
E
R
---
I
H
S
M
G
C
D
P
K
Q
Y
----
L
F
I
P
V
H
P
W
Q
W
E
--------
N
F
I
I
S
-
N
Y
A
E
D
I
Q
--------
D
K
-
G
I
I
Y
L
G
E
S
A
D
D
Y
C
A
Q
Q
S
M
R
T
L
R
N
V
T
N
P
-----
K
R
P
Y
V
K
V
S
L
N
I
L
N
T
S
T
-
L
R
T
L
K
P
Y
S
V
A
S
A
P
A
I
---
S
N
W
L
S
N
V
V
S
Q
D
S
Y
LRDESRVIL
L
-
K
--------
E
--
F
-
S
S
V
M
Y
D
T
N
K
K
A
T
Y
-
G
S
L
G
C
----
I
W
--
R
----
E
S
V
H
H
Y
L
----------------
G
------
E
Q
E
D
A
V
P
F
N
G
L
Y
A
K
E
K
D
----
G
---
T
P
I
I
D
A
W
L
N
-
K
--
Y
G
I
E
N
W
L
R
L
L
---
I
Q
K
A
I
I
P
V
I
H
-
L
-
V
V
-
E
H
G
I
A
L
E
--
S
H
G
Q
N
M
I
L
V
H
K
E
G
L
P
V
R
I
A
L
K
D
F
H
-
E
G
-
L
E
F
Y
R
P
F
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
75.82
15%
-78
- C2 -
2X3J
6
?
A:
[9-588]
------------
L
S
R
M
I
S
E
K
A
A
L
H
G
L
L
N
C
L
I
K
E
F
A
I
P
--------
E
G
Y
L
R
Y
E
WPDEMKGIPPGAYFDG
A
D
W
K
G
I
-
P
M
M
I
--
G
---
L
P
-
D
Q
L
-
Q
----
L
F
V
M
V
D
R
R
D
T
F
G
S
Q
H
Y
L
S
-------
D
V
Y
L
--
R
Q
-
A
Q
G
D
-
W
Q
C
P
D
F
E
P
L
V
A
R
L
L
A
A
--
C
E
H
I
A
----
G
R
-
K
N
P
E
L
Y
E
-
Q
I
L
Q
S
Q
R
L
V
S
A
I
--------
V
S
-----
H
N
GRQR
A
D
A
P
L
Q
H
Y
L
Q
S
E
Q
-
G
L
----------
W
F
G
H
P
S
H
P
A
P
K
A
R
L
W
P
A
H
L
--
G
Q
E
Q
W
A
P
E
F
Q
A
R
A
A
L
H
-
Q
F
E
V
P
V
D
G
L
H
I
G
A
N
G
L
---
T
-----
P
-
Q
Q
V
L
D
-----------------
G
---
F
A
D
Q
Q
P
A
S
P
G
H
----
A
I
I
C
M
H
P
V
Q
A
Q
--------
L
F
M
Q
D
A
R
V
Q
Q
L
L
R
--------
D
N
-
V
I
R
D
L
G
Q
S
G
R
V
A
S
P
T
A
S
I
R
T
W
F
I
D
-
D
H
-
D
Y
F
I
K
G
S
L
N
V
R
I
T
N
C
V
R
K
N
A
-
W
Y
E
L
E
-----
S
T
V
L
I
---
D
R
L
F
R
Q
L
L
D
Q
H
A
D
---------
T
-
L
--------
G
--
G
-
L
V
A
A
A
E
P
G
V
V
S
W
S
-
P
A
A
A
G
----
E
L
D
S
H
----
W
F
R
E
Q
T
G
G
I
L
-
R
E
N
F
C
R
R
T
-----------
G
A
E
R
S
I
M
A
G
T
L
F
A
R
G
V
D
----
L
QP
M
I
Q
T
F
-
L
R
T
H
Y
G
EA
L
D
D
N
A
L
L
Y
W
F
D
-
D
Y
Q
T
R
L
L
R
P
V
L
-
S
-
L
F
F
N
H
G
V
V
M
E
--
P
H
L
Q
N
S
V
L
V
H
Q
Q
G
R
P
Q
Q
V
L
L
R
D
-
F
-
E
G
-
V
K
L
T
D
D
L
G
I
R
Y
-
I
--------
D
D
---
D
I
------
H
--
P
R
V
R
Q
----
S
--
L
-
L
--
Y
-
S
R
E
Q
G
W
N
R
----
I
M
Y
C
L
F
I
N
H
L
S
E
T
I
L
A
L
S
Q
G
R
P
Q
L
A
P
L
M
W
R
R
V
Q
Q
Q
L
R
---
A
I
Q
G
E
L
K
Q
----
P
S
P
E
L
D
A
L
I
A
G
H
---------
P
V
A
C
K
T
N
L
K
V
R
---
L
A
A
-
E
A
---
D
R
Q
A
S
Y
V
R
L
P
S
P
W
G
-----------------
31
Fugue
74.54
13%
-64
- C2 -
2W02
2
?
A:
[5-587]
--------
N
H
D
V
L
S
R
M
I
S
E
K
A
A
L
H
G
L
L
N
C
L
I
K
E
F
A
I
P
EGYLRYEW
P
D
E
M
K
G
I
----------------
P
P
G
A
Y
F
-
D
G
A
D
--
W
---
K
G
-
I
P
M
-
M
----
I
G
L
P
D
Q
-
L
Q
L
F
V
M
V
D
R
R
D
TFG
S
Q
H
Y
L
S
D
V
--
Y
L
R
Q
A
G
D
-
W
Q
C
P
D
F
E
P
L
V
A
R
L
L
A
A
--
C
E
H
I
A
G
RKN
P
E
-
L
Y
E
Q
I
L
Q
-
S
Q
R
L
V
S
A
I
V
S
H
N
--------
G
R
-----
Q
-----
R
A
D
A
P
L
Q
H
Y
L
Q
S
E
Q
G
L
----------
W
F
G
H
P
S
H
P
A
P
K
A
R
L
W
P
A
L
---
G
Q
E
Q
W
A
P
E
F
Q
A
R
A
A
L
H
-
Q
F
E
V
P
V
D
G
L
H
I
G
A
N
G
---------------------
L
T
P
--
Q
Q
V
-
L
--
D
G
---
F
A
D
Q
Q
P
A
S
P
G
H
----
A
I
I
C
M
H
P
V
Q
A
Q
--------
L
F
M
Q
D
-
A
R
V
Q
Q
L
L
--------
R
D
N
V
I
R
D
L
G
Q
S
G
R
V
A
S
P
T
A
S
I
R
T
W
F
I
D
D
H
D
--
Y
F
I
K
G
S
L
N
V
R
I
T
N
C
V
R
K
N
A
-
W
Y
E
L
E
-----
S
T
V
L
I
---
D
R
L
F
R
Q
L
L
D
Q
H
A
D
---------
T
-
L
--------
G
--
G
-
L
V
A
A
A
E
P
G
V
V
S
W
S
-
P
A
A
A
G
----
E
L
--
D
----
S
H
W
F
R
E
Q
T
G
G
-
I
L
R
E
N
F
C
R
R
---
T
------
G
A
E
R
S
I
M
A
G
T
L
F
A
R
G
V
D
LQP
M
I
---
Q
T
F
L
-
R
T
H
Y
-
G
EA
L
D
D
N
A
L
L
Y
W
F
D
-
D
Y
Q
T
R
L
L
R
P
V
L
-
S
-
L
F
F
N
H
G
V
V
M
E
--
P
H
L
Q
N
S
V
L
V
H
Q
Q
G
R
P
Q
Q
V
L
L
R
D
-
F
-
E
G
-
V
K
L
T
D
D
L
G
I
R
Y
I
D
--------
D
D
I
H
P
R
V
------
R
--
Q
S
L
-------------
L
Y
-
S
R
E
Q
G
W
N
R
----
I
M
Y
C
L
F
I
N
H
L
S
E
T
I
L
A
L
S
Q
G
R
P
Q
L
A
P
L
M
W
R
R
V
Q
Q
Q
L
R
---
A
I
Q
G
E
L
K
----
Q
P
S
P
E
L
D
A
L
I
A
G
H
---------
P
V
A
C
K
T
N
L
K
V
R
---
L
----------
A
A
S
Y
V
R
L
P
S
P
W
------------------
1
PsiBlast_PDB
73.85
24%
-58
- C2 -
2X0O
5
?
A:
[171-532]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
G
F
D
A
E
--
D
Y
H
G
Y
A
P
E
A
A
T
P
V
R
L
M
-
W
L
A
V
H
K
D
N
A
H
F
S
C
L
S
D
---
M
---
D
Y
D
-
S
L
M
S
E
----
E
L
G
--
E
S
A
V
T
--
D
F
A
A
R
L
R
E
Q
G
L
H
P
A
D
Y
----
Y
F
M
P
A
H
P
W
Q
W
F
--------
N
K
L
S
L
-
A
F
A
P
Y
V
A
--------
Q
R
-
K
I
V
C
L
G
Y
G
E
E
Q
Y
L
A
Q
Q
S
I
R
T
F
F
N
I
S
R
P
G
K
R
Y
V
K
T
S
L
S
I
L
N
M
G
F
M
R
G
L
S
-
P
Y
Y
M
A
-----
G
T
P
A
I
---
N
E
Y
I
H
D
L
I
S
A
D
P
W
---------
L
R
A
--------
N
--
G
-
F
R
I
L
R
E
V
A
---
S
M
-
G
F
R
N
Y
----
Y
Y
--
E
----
A
A
I
D
T
D
T
P
Y
K
-
K
M
F
S
A
L
W
R
E
---
N
P
L
T
L
I
A
P
G
Q
N
L
M
T
M
A
A
L
L
H
V
D
P
Q
----
G
---
R
A
L
L
-
P
E
L
I
-
Q
--
A
S
G
L
D
A
G
T
W
L
E
-
R
Y
V
D
A
Y
L
T
P
L
I
H
C
-
F
Y
-
A
H
D
L
V
F
M
--
P
H
G
E
N
V
I
L
V
I
Q
D
G
V
P
V
R
A
F
M
K
D
I
A
-
E
E
-
S
S
I
L
N
P
-----
Q
V
--------
R
L
P
Q
A
A
Q
------
R
LA
A
D
V
P
E
----
A
YK
L
-
L
-
T
I
-
F
V
D
V
F
E
G
Y
----
F
R
H
L
---------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
73.63
24%
-58
- C2 -
2X0Q
3
?
A:
[171-532]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
G
F
D
A
E
--
D
Y
H
G
Y
A
P
E
A
A
T
P
V
R
L
M
-
W
L
A
V
H
K
D
N
A
H
F
S
C
L
S
D
---
M
---
D
Y
D
-
S
L
M
S
E
----
E
L
G
--
E
S
A
V
T
--
D
F
A
A
R
L
R
E
Q
G
L
H
P
A
D
Y
----
Y
F
M
P
A
H
P
W
Q
W
F
--------
N
K
L
S
L
-
A
F
A
P
Y
V
A
--------
Q
R
-
K
I
V
C
L
G
Y
G
E
E
Q
Y
L
A
Q
Q
S
I
R
T
F
F
N
I
S
R
P
G
K
R
Y
V
K
T
S
L
S
I
L
N
M
G
F
M
R
G
L
S
-
P
Y
Y
M
A
-----
G
T
P
A
I
---
N
E
Y
I
H
D
L
I
S
A
D
P
W
---------
L
R
A
--------
N
--
G
-
F
R
I
L
R
E
V
A
---
S
M
-
G
F
R
N
Y
----
Y
Y
--
E
----
A
A
I
D
T
D
T
P
Y
K
-
K
M
F
S
A
L
W
R
E
---
N
PLTLIA
P
G
Q
N
L
M
T
M
A
A
L
L
H
V
D
P
Q
----
G
---
R
A
L
L
-
P
E
L
I
-
Q
--
A
S
G
L
D
A
G
T
W
L
E
-
R
Y
V
D
A
Y
L
T
P
L
I
H
C
-
F
Y
-
A
H
D
L
V
F
M
--
P
H
G
E
N
V
I
L
V
I
Q
D
G
V
P
V
R
A
F
M
K
D
I
A
-
E
E
-
S
S
I
L
N
P
-----
Q
V
--------
R
L
P
Q
A
A
Q
------
R
L
A
A
D
V
P
E
----
A
YK
L
-
L
-
T
I
-
F
V
D
V
F
E
G
Y
----
F
R
H
L
---------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
72.00
24%
-58
- C2 -
2X0P
5
?
A:
[171-531]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
G
F
D
A
E
--
D
Y
H
G
Y
A
P
E
A
A
T
P
V
R
L
M
-
W
L
A
V
H
K
D
N
A
H
F
S
C
L
S
D
---
M
---
D
Y
D
-
S
L
M
S
E
----
E
L
G
--
E
S
A
V
T
--
D
F
A
A
R
L
R
E
Q
G
L
H
P
A
D
Y
----
Y
F
M
P
A
H
P
W
Q
W
F
--------
N
K
L
S
L
-
A
F
A
P
Y
V
A
--------
Q
R
-
K
I
V
C
L
G
Y
G
E
E
Q
Y
L
A
Q
Q
S
I
R
T
F
F
N
I
S
R
P
G
K
R
Y
V
K
T
S
L
S
I
L
N
M
G
---
G
L
S
-
P
Y
Y
M
A
-----
G
T
P
A
I
---
N
E
Y
I
H
D
L
I
S
A
D
P
W
---------
L
R
A
--------
N
--
G
-
F
R
I
L
R
E
V
A
---
S
M
-
G
F
R
N
Y
----
Y
Y
--
E
----
A
A
I
D
T
D
T
P
Y
K
-
K
M
F
S
A
L
W
R
E
---
N
PLTLIA
P
G
Q
N
L
M
T
M
A
A
L
L
H
V
D
P
Q
----
G
---
R
A
L
L
-
P
E
L
I
-
Q
--
A
S
G
L
D
A
G
T
W
L
E
-
R
Y
V
D
A
Y
L
T
P
L
I
H
C
-
F
Y
-
A
H
D
L
V
F
M
--
P
H
G
E
N
V
I
L
V
I
Q
D
G
V
P
V
R
A
F
M
K
D
I
A
-
E
E
-
S
S
I
L
N
P
-----
Q
V
--------
R
L
P
Q
A
A
Q
------
R
L
A
A
D
V
P
E
----
A
YK
L
-
L
-
T
I
-
F
V
D
V
F
E
G
Y
----
F
R
H
L
---------------------------------------------------------------------------------------------------------------------------
35
Fugue
65.40
19%
-45
- C2 -
4V2X
10
?
A:
[54-587]
--------------
K
T
L
D
I
Q
S
Y
V
R
D
M
Q
P
G
W
N
L
G
N
T
F
D
--------
A
V
G
Q
D
E
T
----------------
A
W
G
N
P
R
V
T
R
E
L
--
I
---
E
Q
-
I
A
D
-
E
GYK
S
I
R
I
P
V
T
-
W
E
--
N
R
I
G
G
A
P
-------
D
Y
P
I
D
P
Q
F
L
N
R
V
D
-
Q
V
V
Q
W
A
L
E
E
D
L
Y
V
M
I
N
--
L
H
H
D
S
W
---
L
W
--
I
Y
E
M
E
H
-
N
Y
N
G
V
M
V
K
Y
R
S
L
--------
W
E
-----
Q
-----
L
S
N
H
F
K
D
Y
P
T
K
L
M
F
E
S
----------
V
N
E
P
K
F
S
Q
N
W
G
E
I
R
----
E
--
N
H
H
A
L
L
D
D
L
N
T
V
F
F
E
I
-
V
R
Q
S
G
G
Q
N
D
I
R
-----------------
P
L
V
L
----
P
T
M
--
E
T
A
-
T
S
Q
P
L
---
L
N
N
L
Y
Q
T
I
D
K
L
DDP
N
L
I
A
T
V
H
Y
Y
G
F
W
--------
P
F
S
V
N
-
I
A
G
Y
T
--------------------
R
F
E
E
N
S
K
Q
E
I
I
E
A
F
D
R
V
H
H
T
-
F
V
A
R
G
I
P
V
V
L
G
E
F
G
L
L
G
F
D
K
H
T
G
V
I
Q
-----
Q
G
E
K
L
K
F
F
E
F
L
I
H
H
L
N
E
R
D
----------------------
I
--
T
-
H
M
L
W
D
N
--------
G
Q
--------------------
H
F
N
R
H
T
-
Y
E
W
Y
D
----------------
Q
E
L
F
D
M
M
R
A
S
W
E
G
R
S
------------------
S
--
V
A
E
S
N
F
I
Y
L
K
Q
-
G
D
R
I
A
D
A
T
V
S
L
-
Q
-------------
L
H
G
N
E
L
T
G
L
R
A
N
G
Q
R
----
L
T
P
-
G
-
Q
D
-
Y
E
L
N
G
E
R
L
T
V
K
A
H
--------
V
L
S
A
I
A
------------
S
S
G
----
T
--
L
G
T
-
N
G
-
M
V
T
A
E
F
N
R
----
G
A
D
W
H
F
R
V
N
T
Y
R
T
P
-
V
L
Q
S
T
Q
G
H
V
S
N
--
F
S
I
P
A
S
F
N
G
---
N
S
L
A
T
M
E
A
V
Y
V
D
G
G
N
A
G
P
Q
D
W
T
S
F
KEFGYAFSP
S
Y
D
A
N
E
M
K
L
T
E
---
A
F
F
R
E
V
R
D
G
E
V
R
L
T
F
H
F
W
S
G
E
T
V
N
Y
T
I
I
K
N
GN
Q
V
T
G
I
A
A
Q
40
Fugue
62.20
18%
-36
- C3 -
4U1F
-
EIF3B_YEAST
A:
[17-496]
-------------
P
S
S
S
L
K
S
W
L
M
D
D
K
V
--------------------
R
D
Q
F
V
----------------
L
Q
D
D
V
K
-
T
S
V
F
--
W
---
N
----------------------
S
M
F
N
E
E
D
-------
S
L
V
E
--
S
R
E
N
-
W
S
-
T
N
Y
V
R
F
S
P
K
G
T
Y
L
F
S
Y
--
H
----------------
Q
Q
-
G
V
T
A
W
G
G
P
N
F
D
R
--------
L
R
-----
R
-----
F
Y
---
H
P
D
V
R
N
S
S
V
-
S
----------
P
N
E
K
Y
L
V
T
F
S
T
E
P
I
I
V
E
E
D
--
N
E
F
S
P
F
T
K
K
N
E
G
H
Q
L
C
-
I
W
D
I
A
------------------
S
G
L
-
L
M
A
T
F
----
P
V
I
--
K
S
P
-------------------
Y
----
L
K
W
P
L
V
R
W
S
Y
N
--------
D
---
K
-
Y
C
A
R
M
V
G
--------
D
S
-
L
I
V
H
D
A
T
K
N
F
M
P
L
E
A
K
A
L
K
-------
P
-
S
G
I
R
D
F
S
F
A
P
E
G
V
---
K
L
Q
P
-
F
R
--------
N
G
D
E
P
---
S
V
L
L
A
Y
W
T
P
E
T
N
N
---------
S
-
A
--------
C
--
T
-
A
T
I
A
E
V
P
R
------
G
R
V
L
K
----
T
V
--
N
L
---
V
Q
V
S
N
V
T
L
H
W
-
Q
N
Q
A
E
F
L
C
F
---
N
------
V
E
R
H
T
K
S
------------------------
G
K
T
-
Q
--
F
S
N
L
Q
I
C
R
L
T
E
R
D
I
P
V
E
K
V
E
L
K
D
-
S
-
V
F
-
E
F
G
W
E
P
----
H
G
N
R
F
V
T
I
S
V
H
E
V
A
D
M
N
Y
A
I
P
-
A
-
N
T
-
I
R
F
Y
A
P
-
E
T
K
K
R
W
--------
S
L
V
K
E
I
P
------
K
--
T
-
F
A
N
----
T
--
V
-
S
-
W
S
-
P
A
G
R
F
V
V
V
G
A
L
V
G
P
N
M
R
R
S
D
L
Q
F
Y
D
M
D
Y
P
G
E
K
N
I
N
D
N
N
D
V
S
A
S
L
K
D
V
A
H
PTY
S
A
A
T
N
I
T
W
D
P
S
G
R
Y
V
T
A
W
S
S
S
L
K
H
---------
K
V
E
H
G
Y
K
I
F
N
I
AGN
L
V
K
E
D
I
I
A
G
F
K
N
F
A
W
R
P
R
P
---------------------
39
Fugue
57.41
17%
-21
* C3 *
5CWW
-
?
B:
[3-593]
------------
K
I
K
S
F
A
P
A
W
L
N
E
P
A
P
G
H
K
L
F
A
P
K
P
G
----------
P
R
R
T
I
----------------
A
R
R
G
T
E
-
I
F
V
A
--
C
---
G
K
-
Q
I
R
-
W
----
G
D
L
A
Q
L
-
K
E
S
W
E
S
-
R
P
S
D
-------
D
G
A
A
--
T
A
G
Y
R
I
I
-
K
T
P
-
V
A
D
D
I
R
Q
L
V
M
S
P
--
N
Q
D
F
L
A
---
V
L
-
T
S
H
T
V
H
I
-
C
I
L
P
D
S
S
H
L
H
I
Q
DT
T
P
F
K
P
K
F
W
-----
T
-----
L
G
P
T
T
H
V
T
S
R
S
----
A
----------
V
V
S
A
V
W
H
P
L
G
V
N
G
H
A
L
V
T
V
T
E
D
A
I
V
R
V
W
E
L
S
T
A
-----------------
D
R
W
T
---
F
---
D
A
--
P
T
L
A
I
----
D
L
K
--
K
L
A
-
D
--
A
T
---
Y
L
D
Q
D
F
G
V
S
T
-------------
S
A
T
--------
N
K
G
F
S
-
P
D
A
F
D
M
E
--------
V
A
-
A
A
C
F
P
T
R
D
S
G
G
W
-------------
A
P
-
M
T
L
W
L
A
M
T
S
G
D
V
Y
A
L
C
P
L
L
P
-
Q
R
W
T
P
-----
P
P
T
L
I
---
P
S
L
S
A
S
I
V
A
K
V
A
A
---------
A
-
E
D
NPEST
P
E
E
--
R
-
L
V
A
Q
Q
Q
L
E
W
M
S
E
I
D
N
Q
E
P
K
----
L
V
--
E
----
E
A
T
G
E
A
T
I
E
V
-
Y
T
R
P
---------------------
S
R
P
G
L
V
P
K
L
Q
G
----
P
---
F
D
F
D
-
L
N
P
E
-
D
--
E
Q
D
D
E
V
E
--------------
L
K
-
D
-
I
Y
-
V
I
G
E
K
P
R
NG
L
S
L
N
I
I
C
L
L
S
T
S
G
Q
V
K
I
C
L
D
I
D
-
G
-
V
E
-
A
Q
W
L
P
P
R
S
K
N
K
R
L
FAPPPE
P
P
S
L
L
T
F
Q
T
F
D
TLKP
A
--
E
V
T
P
D
----
G
W
P
M
-
F
-
S
E
-
D
A
T
S
P
Y
S
F
----
Y
V
T
H
P
A
G
I
T
Y
I
S
L
----
T
P
W
V
F
R
L
E
S
E
L
Q
S
D
S
E
A
------
G
T
E
F
R
I
D
L
L
A
K
G
Q
G
S
E
R
D
R
I
F
T
Q
T
---------
R
--
T
Q
S
P
L
A
A
A
---
T
S
I
D
D
P
D
L
G
Y
F
I
L
S
A
T
Q
-
T
D
P
I
A
L
F
F
ETP-----------
33
Fugue
56.60
18%
-23
- C2 -
4CI0
4
?
A:
[2-386]
-----------------------------------
S
E
--------
R
I
V
I
S
P
T
----------------
S
R
Q
E
G
H
-
A
E
L
V
--
M
---
E
V
-
D
D
E
G
I
----
V
T
K
G
R
Y
-
F
S
I
---------------
T
P
V
R
--
G
L
E
K
M
V
T
G
K
A
P
E
T
A
P
V
M
V
Q
R
I
C
G
V
---
C
P
I
P
H
---
T
L
A
S
V
E
A
I
D
D
-
S
L
D
I
E
V
P
K
A
G
R
L
--------
L
R
-----
E
-----
L
T
L
A
A
H
H
V
N
S
H
A
I
H
H
F
----------
L
I
A
P
D
F
V
P
----
E
N
L
M
A
D
A
--
I
N
S
V
S
E
I
R
K
N
A
Q
Y
V
V
D
-
M
V
A
G
E
G
---
I
H
P
S
D
V
R
---
I
---
G
G
M
A
D
N
I
T
E
----
L
A
R
--
K
R
L
-
Y
--
A
R
---
L
K
Q
L
K
P
K
V
N
E
H
----
V
E
L
M
I
G
L
I
E
D
K
GLPEGLGV
H
N
Q
P
T
-
L
A
S
H
Q
I
Y
GDRTKFDL
D
R
-
F
T
E
I
M
P
E
S
W
--
Y
D
D
P
E
I
A
K
R
A
C
S
T
I
P
L
-
Y
D
G
R
N
V
E
V
G
----
P
R
A
R
M
V
E
-
F
Q
G
F
K
-----
E
R
G
V
V
---
A
Q
H
V
A
R
A
L
E
M
K
T
A
---------
L
-
S
--------
R
--
A
-
I
E
I
L
D
E
L
D
T
S
A
P
V
-
R
A
D
F
D
E---
R
G
--
T
----
G
K
L
G
I
G
A
I
E
A
P
R
G
L
D
V
H
M
A
K
V
E
N
G
------
K
I
Q
F
Y
S
A
L
V
P
T
T
W
N
I
P
T
----
M
---
G
P
A
T
-
E
G
F
H
-
H
--
E
Y
G
P
H
V
I
R
A
Y
D
P
C
L
S
C
A
T
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
43.37
32%
-14
- C2 -
2W03
2
?
A:
[410-476]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
D
N
A
L
L
Y
W
F
D
-
D
Y
Q
T
R
L
L
R
P
V
L
-
S
L
F
F
-
N
H
G
V
V
M
E
--
P
H
L
Q
N
S
V
L
V
H
Q
Q
G
R
P
Q
Q
V
L
L
R
D
-
F
-
E
G
-
V
K
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
43.09
32%
-23
- C2 -
2X3J
2
?
A:
[410-470]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
D
N
A
L
L
Y
W
F
D
-
D
Y
Q
T
R
L
L
R
P
V
L
-
S
L
F
F
-
N
H
G
V
V
M
E
--
P
H
L
Q
N
S
V
L
V
H
Q
Q
G
R
P
Q
Q
V
L
L
R
D
-
F
-
E
G
-
V
K
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
42.90
32%
-26
- C2 -
2W02
2
?
A:
[410-476]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
D
N
A
L
L
Y
W
F
D
-
D
Y
Q
T
R
L
L
R
P
V
L
-
S
L
F
F
-
N
H
G
V
V
M
E
--
P
H
L
Q
N
S
V
L
V
H
Q
Q
G
R
P
Q
Q
V
L
L
R
D
-
F
-
E
G
-
V
K
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_CBE
42.59
32%
-30
- C2 -
2X3J
3
?
B:
[410-475]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
D
N
A
L
L
Y
W
F
D
-
D
Y
Q
T
R
L
L
R
P
V
L
-
S
L
F
F
-
N
H
G
V
V
M
E
--
P
H
L
Q
N
S
V
L
V
H
Q
Q
G
R
P
Q
Q
V
L
L
R
D
-
F
-
E
G
-
V
K
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_CBE
42.58
32%
-21
- C2 -
2W02
2
?
B:
[410-470]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
D
N
A
L
L
Y
W
F
D
-
D
Y
Q
T
R
L
L
R
P
V
L
-
S
L
F
F
-
N
H
G
V
V
M
E
--
P
H
L
Q
N
S
V
L
V
H
Q
Q
G
R
P
Q
Q
V
L
L
R
D
-
F
-
E
G
-
V
K
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
42.18
32%
-18
- C2 -
3FFE
-
?
A:
[410-476]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
D
N
A
L
L
Y
W
F
D
-
D
Y
Q
T
R
L
L
R
P
V
L
-
S
L
F
F
-
N
H
G
V
V
M
E
--
P
H
L
Q
N
S
V
L
V
H
Q
Q
G
R
P
Q
Q
V
L
L
R
D
-
F
-
E
G
-
V
K
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_CBE
41.93
32%
-21
- C2 -
2X3K
2
?
B:
[410-479]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
D
N
A
L
L
Y
W
F
D
-
D
Y
Q
T
R
L
L
R
P
V
L
-
S
L
F
F
-
N
H
G
V
V
M
E
--
P
H
L
Q
N
S
V
L
V
H
Q
Q
G
R
P
Q
Q
V
L
L
R
D
-
F
-
E
G
-
V
K
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------