@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0116: (2016-03-12 )
MQNKELIQHAAYAAIERILNEYFREENLYQVPPQNHQWSIQLSELETLTGEFRYWSAMGHHMYHPEVWLIDGKSKKITTYKEAIARILQHMAQSADNQTAVQQHMAQIMSDIDNSIHRTARYLQSNTIDYVEDRYIVSEQSLYLGHPFHPTPKSASGFSEADLEKYAPECHTSFQLHYLAVHQDVLLTRYVEGKEDQVEKVLYQLADIDISEIPKDFILLPTHPYQINVLRQHPQYMQYSEQGLIKDLGVSGDLVYPTSSVRTVFSKALNIYLKLPIHVKITNFIRTNDLEQIERTIDAAQVIASVKDEVETPHFKLMFEEGYRALLPNPLGQTVEPEMDLLTNSAMIVREGIPNYHADKDIHVLASLFETMPDSPISKLAQVIEQSGLAPEAWLECYLDRTLLPILKLFSNTGISLEAHVQNTLIELKDGIPDVCFVRDLEGICLSRTIATEKQLVPNVVAASSPVVYAHDEAWHRLKYYVVVNHLGHLVSTIGKATRNEVVLWQLVAHRLMTWKKEYANNAVFVDCVEDLYQTPTIAAKANLMSKLNDCGANPIYTHIPNPICYNKEVSYCESNNS
Atome Classification :
(20 SA)
----------.........10....---....20-.....----------------------....30..----------------------..------....-40...---......50..-----------------......60--.........70.--.--...-----...80........90....-----....100..-.....110...---------------...--.120..------.---...---.---130-.-----------......140.......150......----.160----------------------------------------------........170...---.---...180.---------.-------------.....190.--...-...200....-.---------..-210.-------......220....-..--.230....--...240.......250...--...-----------.260..--.--....--270.......280.---......290---.-....--..300.---....---.--.310--..--......--.320-.........330...-.....340-...---....--..350---.....-...360..-...-..370..-...------..380.......-.------.390.......400...-....410.......420.......430....-....440..-..-....450--......-..460-.---.-..--.-.--..470--.....--..480..------------.....----490....-.-..500--.-.......510.---....-------..520....-.----..530---........540......-.550.-......560.------.-.....570......----------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------MQ
N
K
E
L
I
Q
H
A
A
Y
A
A
I
---
E
R
I
L
N
--
E
Y
F
R
E----------------------ENLYQVPP----------------------QN------
H
Q
W
S
-
I
-
Q
L
S
---
E
L
E
T
L
TGEF
R
-----------------
Y
W
S
AMGH---HMYHP
E
V
W
L
IDG--K--SKK-----
I
T
T
Y
K
E
A
I
A
R
I
L
Q
H
M
A
Q
SA-----D
N
Q
T
A
V
Q
Q
H
-
M
A
Q
I
M
S
D
I
D
N
S
---------------
I
H
R
--
T
A
R
Y
L
Q
------S---NT
I
---
D
---
Y
VE-D-----------
R
Y
I
V
SEQ
S
L
Y
LGHPFHPTPKSASGF----
S
E
A
-----------------------------------------------
D
L
E
K
Y
A
P
ECHT
S
F
Q
---
L
---
H
Y
L
A
V
H
Q
---------
D
-------------
V
L
L
T
R
YVEG--
K
E
D
-
Q
V
E
K
V
L
Y
Q
L
A-D---------I
D
-
I
S
EI-------PK
D
F
I
L
LPTHP
Y
Q
-
I
N
--
V
L
RQH
P
Q
Y
--
M
Q
Y
S
EQ
G
L
I
K
DLGVSGDLV--YP
T
-----------
S
S
V
R
T
V
--
F
--
S
K
A
L
--
N
I
Y
L
K
L
P
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H
V
K
I
T
N
---
F
IRTN
D
L
E
Q
---
I
-
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R
T
I
--
D
A
A
Q
V
I
---
A
S
V
K
---
D
--EV----ET--P
H
F
K
L
M
--FE---E
G
Y
R
A
LLPNP-LGQT-VEP
E
M
D
---
L
LT---N
S
A
M
--
I
V
RE----GIPNY-HAD
K
D
I
H
V
-
L
A
S
-
L
F
E
TMPD-
S
P
I
------
S
K
L
--
A
Q
V
I
E
QS-G------L
A
P
E
A
W
L
E
C
Y
L
D
R
T
L
L
P
-
I
L
K
L
F
SNTG
I
S
L
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A
H
V
Q
N
T
L
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E
LKD-GIPD
V
-
C
F
V
RDL-
E
G
-
I
C
-LSRTIA---
T
E
K
Q
L
V
-
P
N
V
-V-A---A-SS--
P
-
V
--
V
Y
AHD--E
A
W
H
R
--
L
K
Y
Y
V
V
V
------------
N
H
L
G
H
----
L
V
S
T
I
G
K
-A-TRNE---
V
-
V
L
W
Q
L
V
A
H
R
L
M
---
T
W
K
K
-------
E
YANN
A
V
F
V
-
D
----
C
V
E
D
----
L
YQTP
T
I
A
A
K
A
N
L
M
S
K
L
-
N
DCGA-NPIYTHIPNP------
I
-
C
YNKEVSYCESNNS----------------------
29
Fugue
94.23
22%
-78
- C3 -
2W02
2
?
A:
[5-587]
----------
N
H
D
V
L
S
R
M
I
S
E
K
A
A
L
---
H
G
L
L
N
--
C
L
I
K
E
FAIPEGYLRYEWPDEMKGIPPG
A
Y
F
D
G
A
D
W
----------------------
K
G
------
I
P
M
M
-
I
-
G
L
P
---
D
Q
L
Q
L
F
V
M
V
D
-----------------
R
R
D
T
F
G
S
---
Q
H
Y
L
S
D
V
Y
L
R
Q
A
--
G
--
D
W
Q
-----
C
P
D
F
E
P
L
V
A
R
L
L
A
A
C
E
H
I
A
-----
G
R
K
-------
N
P
E
L
Y
E
Q
I
L
Q
S
---------------
Q
R
L
--
V
S
A
I
V
S
------
H
N
GR
Q
R
A
---
D
---
A
P
L
-
Q
-----------
H
Y
L
Q
S
E
Q
G
L
W
F
G
H
P
S
H
P
A
P
K
A
R
L
W
P
----
A
L
------------------------------------------------
G
Q
E
Q
W
A
P
E
F
Q
A
R
A
A
---
L
---
H
Q
F
E
V
P
V
---------
D
-------------
G
L
H
I
G
A
N
G
L
--
T
P
Q
-
Q
V
L
D
G
F
---------------
A
D
-
Q
Q
P
A
-------
S
P
G
H
A
I
I
C
M
H
P
V
Q
-
A
Q
--
L
F
M
Q
D
A
R
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--
Q
Q
L
L
R
D
N
V
I
R
D
L
G
Q
S
G
R
V
A
--
S
P
T
-----------
A
S
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T
W
--
F
--
I
D
D
H
--
D
Y
F
I
K
G
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L
N
V
R
I
T
N
---
C
V
R
K
N
A
W
Y
E
---
L
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L
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---
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L
L
---
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----
A
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TL
G
G
L
V
A
A
--
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---
P
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S
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A
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L
-
D
S
H
W
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---
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-----
G
G
--
I
L
R
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----
N
F
C
R
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-
T
G
A
E
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M
-
A
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T
-
L
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A
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-
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-------
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--
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T
F
L
R
T
H
-
Y
GEALD
D
N
A
L
L
Y
W
F
D
D
Y
Q
T
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L
L
R
P
-
V
L
S
L
F
F
N
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G
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V
M
E
P
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N
S
V
L
V
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-
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R
P
Q
Q
-
V
L
L
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F
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G
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V
K
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L
T
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D
L
G
---
I
R
Y
I
D
D
-
D
I
H
-
P
-
R
---
V
-
R
Q
--
S
-
L
--
L
Y
S
R
E
--
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G
W
N
R
--
I
M
Y
C
L
F
I
------------
N
H
L
S
E
----
T
I
L
A
L
S
Q
G
R
-
P
Q
L
A
---
P
-
L
M
W
R
R
V
Q
Q
Q
L
R
---
A
I
Q
G
-------
E
L
K
Q
P
S
----
P
----
E
L
D
A
----
L
I
A
G
H
P
V
A
C
K
T
N
L
K
V
R
L
-
A
------
A
S
Y
V
R
L
P
S
P
------
W
-------------------------------------
19
HHSearch
91.32
22%
-79
- C3 -
2X3J
6
?
A:
[9-588]
--------------
L
S
R
M
I
S
E
K
A
A
L
---
H
G
L
L
N
--
C
L
I
K
E
----------------------
F
A
I
P
E
G
Y
L
RYEWPDEMKGIPPGAYFDGADW
K
G
------
I
P
M
M
-
I
-
G
L
P
---
D
Q
L
Q
L
F
V
M
V
D
-----------------
R
R
D
T
F
G
S
---
Q
H
Y
L
S
D
V
Y
L
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A
QG
D
--
W
Q
C
-----
P
-
D
F
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P
L
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A
R
L
L
A
A
C
E
H
I
-----------
A
G
R
K
-
N
P
E
L
Y
E
Q
I
L
Q
S
---------------
Q
R
L
--
V
S
A
I
V
S
------
H
---
N
G
R
QRA
D
---
A
P
L
-
Q
-----------
H
Y
L
Q
S
E
Q
G
L
W
F
G
H
P
S
H
P
A
P
K
A
R
L
W
P
----
A
H
L
-----------------------------------------------
G
Q
E
Q
W
A
P
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F
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A
R
A
A
---
L
---
H
Q
F
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V
P
V
---------
D
-------------
G
L
H
I
G
A
N
G
L
---
T
P
---
Q
Q
V
L
D
G
F
A
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D
------------
Q
Q
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A
-------
S
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G
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A
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I
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D
D
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--
D
Y
F
I
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G
S
L
N
V
R
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---
C
V
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K
N
A
W
Y
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---
L
-
E
S
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L
I
D
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L
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---
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L
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A
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----
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G
L
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-
A
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--
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L
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----
N
F
C
R
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T
G
A
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M
-
A
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L
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A
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--
D
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N
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L
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---
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R
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L
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F
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------------
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L
S
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----
T
I
L
A
L
S
Q
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G
R
P
Q
L
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---
P
-
L
M
W
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---
A
I
Q
G
-------
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L
K
---
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P
S
-
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----
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D
A
----
L
I
A
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A
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K
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L
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A
A
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A
D
R
Q
A
S
Y
V
R
L
P
S
P
------
W
-
G
-----------------------------------
30
Fugue
83.14
19%
-68
* C3 *
2X0O
5
?
A:
[7-601]
--PH
P
A
E
I
V
A
H
L
Q
P
E
I
W
N
K
V
N
R
L
L
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---
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K
A
I
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--
E
Y
A
H
E
----------------------
W
L
L
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Q
R
L
----------------------
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------
G
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T
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G
-
F
E
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---
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R
L
T
L
A
D
G
A
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-----------------
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D
E
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---------------
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H
G
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---
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T
L
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A
A
A
---
L
A
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A
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H
P
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F
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A
N
N
G
R
L
G
F
----
D
A
E
-----------------------------------------------
D
Y
H
G
Y
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A
A
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V
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---
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---
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W
L
A
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A
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S
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L
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A
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A
A
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P
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M
F
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L
W
R
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----
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P
L
T
L
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A
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Q
N
L
M
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T
M
A
-
A
L
L
H
V
D
P
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G
R
------
A
L
L
--
P
E
L
I
Q
A
S
-
G
------
L
D
A
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L
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D
A
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I
L
V
I
Q
D
-
G
V
P
V
R
-
A
F
M
K
D
I
-
A
E
-----
E
S
S
I
L
---
N
P
Q
V
R
L
-
P
Q
A
-
A
-
Q
---
R
-
L
A
--
A
-
D
---
V
P
E
A
--
Y
K
L
L
T
--
I
F
V
D
V
F
E
------------
G
Y
F
R
H
----
L
T
Q
I
L
V
E
T
E
-
L
M
P
E
---
H
-
D
F
W
R
L
V
A
G
R
I
A
---
A
Y
Q
Q
-------
A
H
P
Q
R
L
D
K
Y
-
R
----
R
Y
-
D
----
L
F
A
-
P
D
M
I
H
S
C
L
N
R
L
Q
L
-
A
A
--------
P
N
L
P
N
P
------
I
-
A
C
F
---------------------------------
5
PsiBlast_PDB
81.35
24%
-92
- C3 -
2X3J
4
?
A:
[159-588]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
Q
S
E
Q
G
L
W
F
G
H
P
S
H
P
A
P
K
A
R
L
W
P
----
A
H
L
-----------------------------------------------
G
Q
E
Q
W
A
P
E
F
Q
A
R
A
A
---
L
---
H
Q
F
E
V
P
V
---------
D
-------------
G
L
---
H
I
G
A
--
N
G
L
-
T
P
Q
Q
V
L
D
G
F
A
-
D
---------
Q
Q
-
P
A
S
P
-------
G
H
A
I
I
C
M
--
H
P
V
Q
-
A
Q
--
L
F
M
Q
D
A
R
V
--
Q
Q
L
L
R
D
N
V
I
R
D
L
G
Q
S
G
R
V
A
--
S
P
T
-----------
A
S
I
R
T
W
--
F
--
I
D
D
H
--
D
Y
F
I
K
G
S
L
N
V
R
I
T
N
---
C
V
R
K
N
A
W
Y
E
---
L
-
E
S
T
V
--
L
I
D
R
L
F
---
R
Q
L
L
---
D
--
Q
H
----
A
D
--
T
L
G
G
L
V
A
A
A
E
---
P
G
V
V
S
W
S
P
A
A
-
A
G
------
E
L
D
S
H
W
F
R
E
---
Q
T
G
G
--
I
L
R
E
----
N
F
C
R
R
-
T
G
A
E
R
S
I
M
-
A
G
T
-
L
F
A
R
G
V
D
L
Q
P
M
I
Q
T
F
L
R
T
H
Y
--
G
E
A
L
D
D
N
-
A
------
L
L
--
Y
W
F
D
D
Y
Q
T
R
L
L
R
P
-
V
L
S
L
F
F
N
H
G
V
V
M
E
P
H
L
Q
N
S
V
L
V
H
Q
Q
-
G
R
P
Q
Q
-
V
L
L
R
D
F
-
E
G
-
V
K
-
L
T
D
D
L
G
IRY
I
D
D
D
I
H
-
P
R
V
---------
R
Q
--
S
-
L
--
L
Y
S
R
E
--
Q
G
W
N
R
--
I
M
Y
C
L
F
I
------------
N
H
L
S
E
----
T
I
L
A
L
S
Q
-
G
-
R
P
Q
L
---
A
P
L
M
W
R
R
V
Q
Q
Q
L
R
---
A
I
Q
G
-------
E
L
K
Q
P
S
P
E
L
-
D
----
A
-------
L
I
A
G
H
P
V
A
C
K
T
N
L
K
V
R
L
A
A
E
A
D
R
-
Q
A
S
Y
V
R
L
P
S
P
WG------------------------------------------
4
PsiBlast_PDB
81.24
24%
-90
- C3 -
2X3K
2
?
A:
[159-587]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
Q
S
E
Q
G
L
W
F
G
H
P
S
H
P
A
P
K
A
R
L
W
P
----
A
H
L
-----------------------------------------------
G
Q
E
Q
W
A
P
E
F
Q
A
R
A
A
---
L
---
H
Q
F
E
V
P
V
---------
D
-------------
G
L
---
H
I
G
A
--
N
G
L
-
T
P
Q
Q
V
L
D
G
F
A
-
D
---------
Q
Q
-
P
A
S
P
-------
G
H
A
I
I
C
M
--
H
P
V
Q
-
A
Q
--
L
F
M
Q
D
A
R
V
--
Q
Q
L
L
R
D
N
V
I
R
D
L
G
Q
S
G
R
V
A
--
S
P
T
-----------
A
S
I
R
T
W
--
F
--
I
D
D
H
--
D
Y
F
I
K
G
S
L
N
V
R
I
T
N
---
C
V
R
K
N
A
W
Y
E
---
L
-
E
S
T
V
--
L
I
D
R
L
F
---
R
Q
L
L
---
D
--
Q
H
----
A
D
--
T
L
G
G
L
V
A
A
A
E
---
P
G
V
V
S
W
S
P
A
A
-
A
G
------
E
L
D
S
H
W
F
R
E
---
Q
T
G
G
--
I
L
R
E
----
N
F
C
R
R
-
T
G
A
E
R
S
I
M
-
A
G
T
-
L
F
A
R
G
V
D
L
Q
P
M
I
Q
T
F
L
R
T
H
Y
--
G
E
A
L
D
D
N
-
A
------
L
L
--
Y
W
F
D
D
Y
Q
T
R
L
L
R
P
-
V
L
S
L
F
F
N
H
G
V
V
M
E
P
H
L
Q
N
S
V
L
V
H
Q
Q
-
G
R
P
Q
Q
-
V
L
L
R
D
F
-
E
G
-
V
K
-
L
T
D
D
L
G
IRY
I
D
D
D
I
H
-
P
R
V
---------
R
Q
--
S
-
L
--
L
Y
S
R
E
--
Q
G
W
N
R
--
I
M
Y
C
L
F
I
------------
N
H
L
S
E
----
T
I
L
A
L
S
Q
-
G
-
R
P
Q
L
---
A
P
L
M
W
R
R
V
Q
Q
Q
L
R
---
A
I
Q
G
-------
E
L
K
Q
P
S
P
E
L
-
D
----
A
-------
L
I
A
G
H
P
V
A
C
K
T
N
L
K
V
R
L
A
A
------
A
S
Y
V
R
L
P
S
P
W-------------------------------------------
20
HHSearch
80.51
18%
-75
- C3 -
2X0Q
3
?
A:
[15-606]
----------
H
L
Q
P
E
I
W
N
K
V
N
R
L
L
V
---
R
K
A
I
S
--
E
Y
A
H
E
----------------------
W
L
L
E
P
Q
R
L
----------------------
G
P
GETPG
F
E
R
F
R
-
L
-
T
L
A
---
D
G
A
Q
Y
D
F
D
A
Q
------------------
V
M
A
M
R
H
---
W
R
I
P
P
E
S
I
V
K
T
V
--
A
G
V
P
A
P
-----
L
-
D
A
L
Q
F
V
I
E
I
R
D
K
L
G
L
------------
P
V
D
R
-
L
P
I
Y
M
D
E
I
T
S
T
---------------
L
H
G
--
S
A
Y
K
H
G
------
R
---
T
T
L
G
A
A
A
---
L
A
R
-
A
-----------
D
Y
Q
T
I
E
T
S
M
I
E
G
H
P
S
F
V
A
N
N
G
R
L
G
F
----
D
A
E
-----------------------------------------------
D
Y
H
G
Y
A
P
E
A
A
T
P
V
R
---
L
---
M
W
L
A
V
H
K
---------
D
-------------
N
A
H
F
S
C
L
S
D
--
M
D
Y
---
D
S
L
M
S
E
E
L
G
E
S
A
V
T
D
F
A
A
R
L
R
E
Q
G
L
H
-------
P
A
D
Y
Y
F
M
P
A
H
P
W
Q
-
W
F
--
N
K
L
S
-
L
A
F
--
A
P
Y
V
A
Q
R
K
I
V
C
L
G
Y
G
E
E
Q
Y
--
L
A
Q
-----------
Q
S
I
R
T
F
--
F
--
N
I
S
R
PG
K
R
Y
V
K
T
S
L
S
I
L
N
M
G
---
F
M
R
G
L
S
P
Y
Y
---
M
-
A
G
T
P
--
A
I
N
E
Y
I
---
H
D
L
I
---
S
--
A
D
P
W
L
-
R
A
--
N
G
F
R
I
L
--
R
E
---
V
A
S
M
G
F
R
N
Y
Y
-
Y
E
A
A
-
I
D
T
D
T
P
---
Y
K
K
---
M
F
S
A
--
L
W
R
E
----
N
P
L
T
L
I
A
P
G
Q
N
L
M
T
-
M
A
A
-
L
L
H
V
D
P
--
Q
G
R
------
A
L
L
--
P
E
L
I
Q
A
S
-
G
------
L
D
A
G
T
W
L
E
R
Y
V
D
A
Y
L
T
P
-
L
I
H
C
F
Y
A
H
D
L
V
F
M
P
H
G
E
N
V
I
L
V
I
Q
D
-
G
V
P
V
R
-
A
F
M
K
D
I
-
A
E
E
S
S
-
I
L
N
P
Q
V
---
R
L
------
P
Q
-
A
-------
A
Q
--
R
-
L
--
A
A
D
V
P
--
E
A
Y
K
L
LT
I
F
V
D
V
F
E
------------
G
Y
F
R
H
----
L
T
Q
I
L
V
E
-
T
E
L
M
P
E
---
H
-
D
F
W
R
L
V
A
G
R
I
A
---
A
Y
Q
Q
-------
A
H
P
Q
R
--
L
D
-
K
----
Y
R
R
Y
----
D
L
F
A
P
D
M
I
H
S
C
L
N
R
L
Q
L
-
A
N
--------
P
N
L
P
N
P
------
I
-
A
C
F
R
P
S
W
L
----------------------------
1
PsiBlast_PDB
80.42
24%
-92
- C3 -
2W02
2
?
A:
[159-587]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
Q
S
E
Q
G
L
W
F
G
H
P
S
H
P
A
P
K
A
R
L
W
P
----
A
-
L
-----------------------------------------------
G
Q
E
Q
W
A
P
E
F
Q
A
R
A
A
---
L
---
H
Q
F
E
V
P
V
---------
D
-------------
G
L
---
H
I
G
A
--
N
G
L
-
T
P
Q
Q
V
L
D
G
F
A
-
D
---------
Q
Q
-
P
A
S
P
-------
G
H
A
I
I
C
M
--
H
P
V
Q
-
A
Q
--
L
F
M
Q
D
A
R
V
--
Q
Q
L
L
R
D
N
V
I
R
D
L
G
Q
S
G
R
V
A
--
S
P
T
-----------
A
S
I
R
T
W
--
F
--
I
D
D
H
--
D
Y
F
I
K
G
S
L
N
V
R
I
T
N
---
C
V
R
K
N
A
W
Y
E
---
L
-
E
S
T
V
--
L
I
D
R
L
F
---
R
Q
L
L
---
D
--
Q
H
----
A
D
--
T
L
G
G
L
V
A
A
A
E
---
P
G
V
V
S
W
S
P
A
A
-
A
G
------
E
L
D
S
H
W
F
R
E
---
Q
T
G
G
--
I
L
R
E
----
N
F
C
R
R
-
T
G
A
E
R
S
I
M
-
A
G
T
-
L
F
A
R
G
V
D
L
Q
P
M
I
Q
T
F
L
R
T
H
Y
--
G
E
A
L
D
D
N
-
A
------
L
L
--
Y
W
F
D
D
Y
Q
T
R
L
L
R
P
-
V
L
S
L
F
F
N
H
G
V
V
M
E
P
H
L
Q
N
S
V
L
V
H
Q
Q
-
G
R
P
Q
Q
-
V
L
L
R
D
F
-
E
G
-
V
K
-
L
T
D
D
L
G
IRY
I
D
D
D
I
H
-
P
R
V
---------
R
Q
--
S
-
L
--
L
Y
S
R
E
--
Q
G
W
N
R
--
I
M
Y
C
L
F
I
------------
N
H
L
S
E
----
T
I
L
A
L
S
Q
-
G
-
R
P
Q
L
---
A
P
L
M
W
R
R
V
Q
Q
Q
L
R
---
A
I
Q
G
-------
E
L
K
Q
P
S
P
E
L
-
D
----
A
-------
L
I
A
G
H
P
V
A
C
K
T
N
L
K
V
R
L
A-------
A
S
Y
V
R
L
P
S
P
W-------------------------------------------
3
PsiBlast_PDB
79.67
24%
-90
- C3 -
2W04
-
?
A:
[159-587]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
Q
S
E
Q
G
L
W
F
G
H
P
S
H
P
A
P
K
A
R
L
W
P
----
A
H
L
-----------------------------------------------
G
Q
E
Q
W
A
P
E
F
Q
A
R
A
A
---
L
---
H
Q
F
E
V
P
V
---------
D
-------------
G
L
---
H
I
G
A
--
N
G
L
-
T
P
Q
Q
V
L
D
G
F
A
-
D
---------
Q
Q
-
P
A
S
P
-------
G
H
A
I
I
C
M
--
H
P
V
Q
-
A
Q
--
L
F
M
Q
D
A
R
V
--
Q
Q
L
L
R
D
N
V
I
R
D
L
G
Q
S
G
R
V
A
--
S
P
T
-----------
A
S
I
R
T
W
--
F
--
I
D
D
H
--
D
Y
F
I
K
G
S
L
N
V
R
I
T
N
---
C
V
R
K
N
A
W
Y
E
---
L
-
E
S
T
V
--
L
I
D
R
L
F
---
R
Q
L
L
---
D
--
Q
H
----
A
D
--
T
L
G
G
L
V
A
A
A
E
---
P
G
V
V
S
W
S
P
A
A
-
A
G
------
E
L
D
S
H
W
F
R
E
---
Q
T
G
G
--
I
L
R
E
----
N
F
C
R
R
-
T
G
A
E
R
S
I
M
-
A
G
T
-
L
F
A
R
G
V
D
L
Q
P
M
I
Q
T
F
L
R
T
H
Y
--
G
E
A
L
D
D
N
-
A
------
L
L
--
Y
W
F
D
D
Y
Q
T
R
L
L
R
P
-
V
L
S
L
F
F
N
H
G
V
V
M
E
P
H
L
Q
N
S
V
L
V
H
Q
Q
-
G
R
P
Q
Q
-
V
L
L
R
D
F
-
E
G
-
V
K
-
L
T
D
D
L
G
IRY
I
D
D
D
I
H
-
P
R
V
---------
R
Q
--
S
-
L
--
L
Y
S
R
E
--
Q
G
W
N
R
--
I
M
Y
C
L
F
I
------------
N
H
L
S
E
----
T
I
L
A
L
S
Q
-
G
-
R
P
Q
L
---
A
P
L
M
W
R
R
V
Q
Q
Q
L
R
---
A
I
Q
G
-------
E
L
K
Q
P
S
P
E
L
-
D
----
A
-------
L
I
A
G
H
P
V
A
C
K
T
N
L
K
V
R
L
A-------
A
S
Y
V
R
L
P
S
P
W-------------------------------------------
6
PsiBlast_PDB
79.63
24%
-96
- C3 -
3FFE
-
?
A:
[159-587]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
Q
S
E
Q
G
L
W
F
G
H
P
S
H
P
A
P
K
A
R
L
W
P
----
A
H
L
-----------------------------------------------
G
Q
E
Q
W
A
P
E
F
Q
A
R
A
A
---
L
---
H
Q
F
E
V
P
V
---------
D
-------------
G
L
---
H
I
G
A
--
N
G
L
-
T
P
Q
Q
V
L
D
G
F
A
-
D
---------
Q
Q
-
P
A
S
P
-------
G
H
A
I
I
C
M
--
H
P
V
Q
-
A
Q
--
L
F
M
Q
D
A
R
V
--
Q
Q
L
L
R
D
N
V
I
R
D
L
G
Q
S
G
R
V
A
--
S
P
T
-----------
A
S
I
R
T
W
--
F
--
I
D
D
H
--
D
Y
F
I
K
G
S
L
N
V
R
I
T
N
---
C
V
R
K
N
A
W
Y
E
---
L
-
E
S
T
V
--
L
I
D
R
L
F
---
R
Q
L
L
---
D
--
Q
H
----
A
D
--
T
L
G
G
L
V
A
A
A
E
---
P
G
V
V
S
W
S
P
A
A
-
A
G
------
E
L
D
S
H
W
F
R
E
---
Q
T
G
G
--
I
L
R
E
----
N
F
C
R
R
-
T
G
A
E
R
S
I
M
-
A
G
T
-
L
F
A
R
G
V
D
L
Q
P
M
I
Q
T
F
L
R
T
H
Y
--
G
E
A
L
D
D
N
-
A
------
L
L
--
Y
W
F
D
D
Y
Q
T
R
L
L
R
P
-
V
L
S
L
F
F
N
H
G
V
V
M
E
P
H
L
Q
N
S
V
L
V
H
Q
Q
-
G
R
P
Q
Q
-
V
L
L
R
D
F
-
E
G
-
V
K
-
L
T
D
D
L
G
IRY
I
D
D
D
I
H
-
P
R
V
-
R
-
Q
---
S
-------
L
--
L
Y
S
R
E
--
Q
G
W
N
R
--
I
M
Y
C
L
F
I
------------
N
H
L
S
E
----
T
I
L
A
L
S
Q
-
G
-
R
P
Q
L
---
A
P
L
M
W
R
R
V
Q
Q
Q
L
R
---
A
I
Q
G
-------
E
L
K
Q
P
S
P
E
L
-
D
----
A
-------
L
I
A
G
H
P
V
A
C
K
T
N
L
K
V
R
L
A-------
A
S
Y
V
R
L
P
S
P
W-------------------------------------------
2
PsiBlast_PDB
79.10
24%
-89
- C3 -
2W03
2
?
A:
[159-587]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
Q
S
E
Q
G
L
W
F
G
H
P
S
H
P
A
P
K
A
R
L
W
P
----
A
H
L
-----------------------------------------------
G
Q
E
Q
W
A
P
E
F
Q
A
R
A
A
---
L
---
H
Q
F
E
V
P
V
---------
D
-------------
G
L
---
H
I
G
A
--
N
G
L
-
T
P
Q
Q
V
L
D
G
F
A
-
D
---------
Q
Q
-
P
A
S
P
-------
G
H
A
I
I
C
M
--
H
P
V
Q
-
A
Q
--
L
F
M
Q
D
A
R
V
--
Q
Q
L
L
R
D
N
V
I
R
D
L
G
Q
S
G
R
V
A
--
S
P
T
-----------
A
S
I
R
T
W
--
F
--
I
D
D
H
--
D
Y
F
I
K
G
S
L
N
V
R
I
T
N
---
C
V
R
K
N
A
W
Y
E
---
L
-
E
S
T
V
--
L
I
D
R
L
F
---
R
Q
L
L
---
D
--
Q
H
----
A
D
--
T
L
G
G
L
V
A
A
A
E
---
P
G
V
V
S
W
S
P
A
A
-
A
G
------
E
L
D
S
H
W
F
R
E
---
Q
T
G
G
--
I
L
R
E
----
N
F
C
R
R
-
T
G
A
E
R
S
I
M
-
A
G
T
-
L
F
A
R
G
V
D
L
Q
P
M
I
Q
T
F
L
R
T
H
Y
--
G
E
A
L
D
D
N
-
A
------
L
L
--
Y
W
F
D
D
Y
Q
T
R
L
L
R
P
-
V
L
S
L
F
F
N
H
G
V
V
M
E
P
H
L
Q
N
S
V
L
V
H
Q
Q
-
G
R
P
Q
Q
-
V
L
L
R
D
F
-
E
G
-
V
K
-
L
T
D
D
L
G
IRY
I
D
D
D
I
H
-
P
R
V
---------
R
Q
--
S
-
L
--
L
Y
S
R
E
--
Q
G
W
N
R
--
I
M
Y
C
L
F
I
------------
N
H
L
S
E
----
T
I
L
A
L
S
Q
-
G
-
R
P
Q
L
---
A
P
L
M
W
R
R
V
Q
Q
Q
L
R
---
A
I
Q
G
-------
E
L
K
Q
P
S
P
E
L
-
D
----
A
-------
L
I
A
G
H
P
V
A
C
K
T
N
L
K
V
R
L
A-------
A
S
Y
V
R
L
P
S
P
W-------------------------------------------
21
HHSearch
78.70
18%
-74
- C3 -
3TO3
2
?
A:
[14-603]
----------
A
I
E
S
E
D
Y
I
S
V
R
R
R
V
L
---
R
Q
L
V
E
--
S
L
I
Y
E
----------------------
G
I
I
T
P
A
R
I
----------------------
E
K
EE
Q
---
I
L
F
L
-
I
Q
G
L
D
EDN
K
S
V
T
Y
E
C
Y
G
R
-----------------
E
R
I
T
F
G
R
---
I
S
I
D
S
L
I
V
R
V
Q
D
--
G
--
K
Q
E
-----
I
Q
S
V
A
Q
F
L
E
E
V
F
R
V
V
N
V
------------
E
Q
T
K
-
L
D
S
F
I
H
E
L
E
Q
T
---------------
I
F
K
--
D
T
I
A
Q
Y
------
E
---
R
C
------------
K
-----------
S
Y
D
E
L
E
N
H
L
I
D
G
H
P
Y
H
P
S
Y
K
A
R
I
G
F
----
Q
Y
R
-----------------------------------------------
D
N
F
R
Y
G
Y
E
F
M
R
P
I
K
---
L
---
I
W
I
A
A
H
K
---------
K
-------------
N
A
T
V
G
Y
E
N
E
--
V
I
Y
---
D
K
I
L
K
S
E
V
G
E
R
K
L
E
A
Y
K
E
R
I
H
S
M
G
C
D
-------
P
K
Q
Y
L
F
I
P
V
H
P
W
Q
-
W
E
--
N
F
I
I
S
-
N
Y
--
A
E
D
I
Q
D
K
G
I
I
Y
L
G
E
S
A
D
D
Y
--
C
A
Q
-----------
Q
S
M
R
T
L
--
R
--
N
V
T
N
PK
R
P
Y
V
K
V
S
L
N
I
L
N
T
S
---
T
L
R
T
L
K
P
Y
S
---
V
-
A
S
A
P
--
A
I
S
N
W
L
---
S
N
V
V
---
S
--
Q
D
SYLR
D
E
--
S
R
V
I
L
L
--
K
E
---
F
S
S
V
M
Y
D
T
N
K
----------
K
A
---
T
Y
G
---
S
L
G
C
--
I
W
R
E
----
S
V
H
H
Y
L
G
E
Q
E
D
A
V
P
-
F
N
G
-
L
Y
A
K
E
K
--
D
G
T
------
P
I
I
--
D
A
W
L
N
K
Y
-
G
--------
I
E
N
W
L
R
L
L
I
Q
K
A
I
I
P
-
V
I
H
L
V
V
E
H
G
I
A
L
E
S
H
G
Q
N
M
I
L
V
H
K
E
-
G
L
P
V
R
-
I
A
L
K
D
F
H
E
G
-
L
E
-
F
Y
R
P
F
L
---
K
E
M
N
K
C
-
P
D
F
T
K
M
H
K
T
Y
A
-
N
G
KM
N
D
F
FE
M
D
R
I
E
--
C
L
Q
E
M
--
V
L
D
A
L
F
L
------------
F
N
V
G
E
----
L
A
F
V
L
A
D
-
K
Y
E
W
K
E
---
E
-
S
F
W
M
I
V
V
E
E
I
E
---
N
H
F
R
-------
K
Y
P
H
L
--
K
D
-
R
----
F
E
S
I
----
Q
L
Y
T
P
T
F
Y
A
E
Q
L
T
K
R
R
L
-
Y
I
D
V
E
--
S
L
V
H
E
V
P
N
P
------
L
-
Y
R
A
R
Q
L
N
I
Q
K
S
-------------------------
9
PsiBlast_PDB
78.10
23%
-72
- C3 -
2X0Q
3
?
A:
[122-602]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
E
I
T
S
T
---------------
L
H
G
--
S
A
Y
K
H
G
------
R
---
T
T
L
---
G
A
A
A
L
A
R
-
A
-----------
D
Y
Q
T
I
E
T
S
M
I
E
G
H
P
S
F
V
A
N
N
G
R
L
G
F
----
D
A
E
-----------------------------------------------
D
Y
H
G
Y
A
P
E
A
A
T
P
V
R
---
L
---
M
W
L
A
V
H
K
---------
D
N
A
H
F
S
C
L
SDMD
Y
D
S
L
M
S
E
--
E
L
--
G
E
S
-
A
V
T
D
F
A
A
R
L
R
-
E
---------
Q
G
-
L
H
---------
P
A
D
Y
Y
F
M
P
A
H
P
W
Q
W
F
N
--
K
L
S
L
--
A
F
--
A
P
Y
V
A
Q
R
K
I
V
C
L
G
Y
G
E
E
Q
Y
--
L
A
Q
-----------
Q
S
I
R
T
F
--
F
N
I
S
R
P
G
--
K
R
Y
V
K
T
S
L
S
I
L
N
M
G
---
F
M
R
G
L
S
P
Y
Y
---
M
-
A
G
T
P
--
A
I
N
E
Y
I
H
D
L
I
S
A
D
---
P
--
W
L
----
R
A
--
N
G
F
R
I
L
--
R
E
V
A
S
M
G
F
R
N
Y
Y
Y
E
A
-
A
I
D
T
-
D
T
P
Y
K
K
---
M
F
-----
S
A
L
--
W
R
E
N
----
P
L
T
L
I
-
A
P
G
Q
N
L
M
T
-
M
A
A
-
L
L
H
V
D
P
Q
-
G
-
R
------
A
L
L
--
P
E
L
I
Q
A
S
-
G
------
L
D
A
G
T
W
L
E
R
Y
V
D
A
Y
L
T
P
-
L
I
H
C
F
Y
A
H
D
L
V
F
M
P
H
G
E
N
V
I
L
V
I
Q
D
-
G
V
P
V
R
-
A
F
M
K
D
------------
I
A
---
E
E
S
S
I
L
N
P
Q
V
-
R
-
L
---
P
-
Q
A
--
A
-
Q
--
R
L
A
A
D
V
P
E
A
Y
K
L
--
L
T
I
F
V
D
V
FE----------
G
Y
F
R
H
----
L
T
Q
I
L
V
E
-
T
E
L
M
P
E
---
H
-
D
F
W
R
L
V
A
G
R
I
A
---
A
Y
Q
Q
A
H
PQR
L
D
K
Y
R
R
Y
D
L
F
A
P
D
----
M
I
H
S
----
C
L
N
R
L
Q
L
A
N
-------------------
P
N
L
P
N
P
------
I
A
C
F
R
---------------------------------
7
PsiBlast_PDB
76.26
23%
-77
- C3 -
2X0O
5
?
A:
[122-601]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
E
I
T
S
T
---------------
L
H
G
--
S
A
Y
K
H
G
------
R
---
T
T
L
---
G
A
A
A
L
A
R
-
A
-----------
D
Y
Q
T
I
E
T
S
M
I
E
G
H
P
S
F
V
A
N
N
G
R
L
G
F
----
D
A
E
-----------------------------------------------
D
Y
H
G
Y
A
P
E
A
A
T
P
V
R
---
L
---
M
W
L
A
V
H
K
---------
D
N
A
H
F
S
C
L
SDMD
Y
D
S
L
M
S
E
--
E
L
--
G
E
S
-
A
V
T
D
F
A
A
R
L
R
-
E
---------
Q
G
-
L
H
---------
P
A
D
Y
Y
F
M
P
A
H
P
W
Q
W
F
N
--
K
L
S
L
--
A
F
--
A
P
Y
V
A
Q
R
K
I
V
C
L
G
Y
G
E
E
Q
Y
--
L
A
Q
-----------
Q
S
I
R
T
F
--
F
NI
S
R
P
G
--
K
R
Y
V
K
T
S
L
S
I
L
N
M
G
---
F
M
R
G
L
S
P
Y
Y
---
M
-
A
G
T
P
--
A
I
N
E
Y
I
H
D
L
I
S
A
D
---
P
--
W
L
----
R
A
--
N
G
F
R
I
L
--
R
E
V
A
S
M
G
F
R
N
Y
Y
Y
E
A
-
A
I
D
T
-
D
T
P
Y
K
K
---
M
F
-----
S
A
L
--
W
R
E
N
----
P
L
T
L
I
-
A
P
G
Q
N
L
M
T
-
M
A
A
-
L
L
H
V
D
P
Q
-
G
-
R
------
A
L
L
--
P
E
L
I
Q
A
S
-
G
------
L
D
A
G
T
W
L
E
R
Y
V
D
A
Y
L
T
P
-
L
I
H
C
F
Y
A
H
D
L
V
F
M
P
H
G
E
N
V
I
L
V
I
Q
D
-
G
V
P
V
R
-
A
F
M
K
D
------------
I
A
---
E
E
S
S
I
L
N
P
Q
V
-
R
-
L
---
P
-
Q
A
--
A
-
Q
--
R
L
A
A
D
VP
E
A
Y
K
L
--
L
T
I
F
V
D
V
FE----------
G
Y
F
R
H
----
L
T
Q
I
L
V
E
-
T
E
L
M
P
E
---
H
-
D
F
W
R
L
V
A
G
R
I
A
---
A
Y
Q
Q
A
H
PQR
L
D
K
Y
R
R
Y
D
L
F
A
P
D
----
M
I
H
S
----
C
L
N
R
L
Q
L
A
-------------------
A
P
N
L
P
N
P
------
I
A
C
F
----------------------------------
8
PsiBlast_PDB
75.78
23%
-76
- C3 -
2X0P
5
?
A:
[122-602]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
E
I
T
S
T
---------------
L
H
G
--
S
A
Y
K
H
G
------
R
---
T
T
L
---
G
A
A
A
L
A
R
-
A
-----------
D
Y
Q
T
I
E
T
S
M
I
E
G
H
P
S
F
V
A
N
N
G
R
L
G
F
----
D
A
E
-----------------------------------------------
D
Y
H
G
Y
A
P
E
A
A
T
P
V
R
---
L
---
M
W
L
A
V
H
K
---------
D
N
A
H
F
S
C
L
SDMD
Y
D
S
L
M
S
E
--
E
L
--
G
E
S
-
A
V
T
D
F
A
A
R
L
R
-
E
---------
Q
G
-
L
H
---------
P
A
D
Y
Y
F
M
P
A
H
P
W
Q
W
F
N
--
K
L
S
L
--
A
F
--
A
P
Y
V
A
Q
R
K
I
V
C
L
G
Y
G
E
E
Q
Y
--
L
A
Q
-----------
Q
S
I
R
T
F
--
F
N
I
S
R
P
G
--
K
R
Y
V
K
T
S
L
S
I
L
N
M
G
------
G
L
S
P
Y
Y
---
M
-
A
G
T
P
--
A
I
N
E
Y
I
H
D
L
I
S
A
D
---
P
--
W
L
----
R
A
--
N
G
F
R
I
L
--
R
E
V
A
S
M
G
F
R
N
Y
Y
Y
E
A
-
A
I
D
T
-
D
T
P
Y
K
K
---
M
F
-----
S
A
L
--
W
R
E
N
----
P
L
T
L
I
-
A
P
G
Q
N
L
M
T
-
M
A
A
-
L
L
H
V
D
P
Q
-
G
-
R
------
A
L
L
--
P
E
L
I
Q
A
S
-
G
------
L
D
A
G
T
W
L
E
R
Y
V
D
A
Y
L
T
P
-
L
I
H
C
F
Y
A
H
D
L
V
F
M
P
H
G
E
N
V
I
L
V
I
Q
D
-
G
V
P
V
R
-
A
F
M
K
D
------------
I
A
---
E
E
S
S
I
L
N
P
Q
V
-
R
-
L
---
P
-
Q
A
--
A
-
Q
--
R
L
A
A
D
V
P
E
A
Y
K
L
--
L
T
I
F
V
D
V
FE----------
G
Y
F
R
H
----
L
T
Q
I
L
V
E
-
T
E
L
M
P
E
---
H
-
D
F
W
R
L
V
A
G
R
I
A
---
A
Y
Q
Q
A
H
PQR
L
D
K
Y
R
R
Y
D
L
F
A
P
D
----
M
I
H
S
----
C
L
N
R
L
Q
L
A
N
------------------
A
P
N
L
P
N
P
------
I
A
C
F
R
---------------------------------
10
PsiBlast_PDB
65.25
21%
-59
- C3 -
3TO3
2
?
A:
[83-479]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
S
--
L
--
I
V
R
-----
V
Q
D
G
K
Q
E
I
Q
S
V
A
Q
F
L
E
E
V
F
-----
R
V
V
N
V
E
Q
T
K
-
L
D
S
F
I
H
E
L
E
Q
T
---------------
I
F
K
D
T
I
A
Q
Y
E
R
------
C
-----------------
K
-----------
S
Y
D
E
L
E
N
H
L
I
D
G
H
P
Y
H
P
S
Y
K
A
R
I
G
F
----
Q
Y
R
-----------------------------------------------
D
N
F
R
Y
G
Y
E
F
M
R
P
I
K
---
L
---
I
W
I
A
A
H
K
KNATVGYEN
E
-------------
V
I
Y
D
K
I
L
K
S
--
E
V
G
-
E
R
K
L
E
A
Y
K
E
R
-
I
---------
H
S
-
M
G
C
D
-------
P
K
Q
Y
L
F
I
P
V
H
P
W
Q
-
W
E
N
F
I
I
S
N
Y
A
E
D
--
I
Q
--
D
K
G
I
I
Y
-
L
G
E
S
A
D
D
Y
--
C
A
Q
-----------
Q
S
M
R
T
L
R
N
V
--
T
N
P
K
--
R
P
Y
V
K
V
S
L
N
I
L
N
T
S
---
T
L
R
T
L
K
--------
P
Y
S
V
--
A
S
A
P
A
I
---
S
N
W
L
---
S
--
N
V
----
V
S
--
Q
D
S
Y
L
R
--
D
E
---
S
--
R
V
I
L
L
K
E
-
F
S
S
V
-
M
Y
D
T
N
K
---
K
A
T
---
Y
G
S
L
G
C
I
W
R
E
----
S
V
H
H
Y
-
L
G
E
Q
E
D
A
V
P
F
N
G
-
L
Y
A
K
E
K
D
G
T
P
I
--------
I
--
D
A
W
L
N
K
Y
-
G
------
I
--
E
N
W
L
R
L
L
I
Q
K
A
I
I
P
-
V
I
H
L
V
V
E
H
G
I
A
L
E
S
H
G
Q
N
M
I
L
V
H
K
E
-
G
L
P
V
R
-
I
A
L
K
D
F
H
E
G
-
L
E
-
F
Y
R
P
F
L
---
K
E
M
N
K
C
-
P
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Fugue
58.88
17%
-43
- C2 -
4R3Z
-
SYRC_HUMAN
B:
[17-675]
DV
L
V
S
E
C
S
A
R
L
L
Q
Q
E
E
E
I
K
S
L
T
A
E
I
---
D
R
L
K
N
CG
C
L
G
A
S
----------------------
P
N
L
E
Q
L
Q
E
----------------------
E
N
------
L
K
L
K
-
Y
-
R
L
N
---
I
L
R
K
S
L
Q
A
E
R
N
K
PTKNMIN
I
I
S
R
L
Q
E
V
F
G
H
A
I
K
A
A
Y
P
D
L
E
N
P
P
L
L
V
T
P
S
--
Q
--
Q
A
K
-----
F
G
D
Y
Q
C
N
S
A
M
G
I
S
Q
M
L
K
T
K
-----
E
Q
K
V
N
P
R
E
I
-
A
E
N
I
T
K
H
L
P
D
N
ECIE
K
V
E
I
A
G
PG
F
I
N
V
H
L
--
R
K
D
F
V
S
------
E
---
Q
L
T
---
S
---
L
L
V
-
N
GVQLPALGEN
K
K
V
I
V
D
F
S
S
P
N
I
A
K
E
M
H
V
G
H
L
R
S
T
I
I
----
G
E
S
I
S
R
L
F
E
F
A
GYD
V
L
R
L
NHVGDWGT
Q
F
G
M
L
I
A
H
L
Q
D
K
FPDYLTVSPPIG
D
L
Q
V
F
Y
K
E
S
K
K
R
F
D
---
T
---
E
E
E
F
K
K
R
---------
A
-------------
Y
Q
C
V
V
L
L
Q
G
--
K
N
P
-
D
I
T
K
A
W
K
L
I
C
-
D
---------
V
S
-
R
Q
E
L
-------
N
K
I
Y
D
A
L
D
------
V
S
--
L
I
E
R
G
E
S
F
--
Y
Q
D
R
M
N
D
I
V
K
E
F
E
D
R
G
-
F
V
--
Q
V
D
-----------
D
G
R
K
I
V
--
F
--
V
P
G
C
--
S
I
----
P
L
T
I
V
K
S
D
GGY
T
Y
D
T
S
D
L
A
A
---
I
-
K
Q
R
L
FE
E
K
A
D
M
I
---
I
Y
V
V
---
D
--
N
G
----
Q
S
--
V
H
F
Q
T
I
--
F
A
---
A
A
Q
M
I
G
W
Y
D
P
K
V
T
R
V
-
F
H
A
G
F
G
---
V
V
L
G
ED
K
K
K
F
--
K
T
R
S
----
G
E
T
V
R
-
L
M
D
L
L
G
E
G
-
L
K
R
-
S
M
D
K
L
K
E
-
K
E
R
------
D
K
V
LT
A
E
E
L
N
A
A
-
Q
------
T
S
V
A
Y
G
C
I
K
Y
A
D
L
S
H
N
R
-
L
N
D
Y
I
F
S
F
D
K
M
L
D
D
R
-
G
N
T
A
A
Y
L
L
Y
-
A
F
T
R
I
-
R
S
I
A
R
L
-
A
N
-
I
-----------
D
E
E
M
L
Q
-
K
A
----
A
---
R
-
E
T
--
K
-
I
--
L
L
D
H
E
--
K
E
W
K
L
--
G
R
C
I
L
------------------
R
----
F
P
E
I
L
Q
K
-
I
-
L
D
D
----------
L
F
L
H
T
L
C
---
D
Y
I
Y
-------
E
L
A
T
A
F
T
E
F
-
Y
DSCY
C
V
E
K
----
D
R
Q
T
G
K
I
L
K
V
--
N
M
W
R
M
-
L
L
C
E
A
-
V
A
A
V
M
A
K
G
F
D
------
I
-
L
G
I
K
P
V
Q
R
M
---------------------------
31
Fugue
54.60
14%
-55
- C4 -
4C0E
-
?
A:
[9-528]
----------
L
E
A
A
H
L
L
E
Q
------
M
--
E
Y
V
F
D
--
E
W
I
H
L
----------------------
C
N
---
N
P
H
----------------------
A
T
------
E
R
A
A
M
I
-
F
V
H
---
Q
L
H
S
---------------------------------------
V
Q
L
V
T
N
--
R
--
D
E
F
-----
L
L
F
L
R
H
A
L
D
K
S
V
E
R
F
E
Q
G
I
-----
H
S
G
----
A
S
-
I
A
E
S
F
Q
A
V
E
A
L
---------------
V
K
L
--
I
I
I
F
V
K
------
S
---
H
S
A
---
A
---
V
A
F
M
D
-----------
S
I
L
A
L
G
V
L
V
A
N
S
H
H
V
K
R
G
E
N
----
F
----
N
Q
R
-----------------------------------------------
V
F
Y
R
F
F
A
L
L
L
H
E
V
G
---
L
L
A
G
H
F
S
K
S
H
Y
---------
E
-------------
Q
I
I
L
N
F
A
A
R
--
L
F
D
M
R
P
N
L
--------------------
L
P
G
F
-------
A
C
A
W
A
G
L
V
S
H
R
A
F
-
L
P
--
V
I
L
G
L
P
D
E
KG
W
A
P
F
T
K
L
L
E
Q
F
L
G
C
V
G
E
L
V
K
T
F
T
V
-----------
S
S
L
G
K
E
M
-
Y
--
H
A
A
L
--
K
I
L
I
V
L
Q
H
D
F
P
I
Y
L
---
D
K
F
R
V
Q
L
C
Q
S
L
P
L
-
H
A
T
Q
--
L
V
N
L
I
L
---
A
A
I
P
---
P
--
N
C
----
N
S
--
L
--------
A
---
D
P
F
Q
A
G
L
K
V
D
-
K
I
P
D
M
K
E
R
P
P
T
---
A
F
D
---
S
A
G
L
--
L
R
E
A
----
G
L
---------
L
D
I
-
L
E
R
M
L
Q
N
G
P
S
E
-
D
G
V
------
A
Q
I
--
N
H
A
I
N
K
S
-
T
--------
S
F
G
Y
V
P
L
G
V
N
R
R
L
I
D
A
V
V
A
R
F
A
E
F
A
I
N
R
A
S
S
R
S
D
S
A
I
F
V
A
G
-
A
--------
N
D
I
-
K
T
-
L
Q
M
L
V
T
E
V
-----
S
P
E
A
R
-
Y
Y
L
-
V
-
S
---
S
M
V
N
--
E
-
L
--
R
Y
P
N
----
A
Y
T
N
--
Y
F
S
Q
A
L
L
------------
D
I
F
G
H
----
D
M
S
D
P
E
E
-
N
-
L
V
R
E
---
Q
-
I
V
R
V
L
L
E
R
V
L
G
---
Y
W
P
Q
-------
P
W
G
L
I
I
T
I
L
-
E
----
L
L
K
N
DKYL
F
F
E
L
P
F
I
K
A
T
P
E
V
A
E
R
F
-
T
A
L
A
R
-
S
A
A
---------------------------------------------------
34
Fugue
53.55
17%
-20
* C5 *
5AWO
2
?
A:
[15-610]
-----P
V
T
A
A
P
P
L
R
L
A
S
R
N
S
V
F
T
R
S
G
A
G
P
R
Y
W
N
--
I
Y
G
Y
S
----------------------
F
P
H
N
A
-
P
I
----------------------
P
E
------
N
E
W
K
-
V
-
N
I
D
---
W
L
A
G
-----------------------
N
F
A
D
F
G
Y
---
D
I
A
C
T
D
G
W
-
I
E
G
--
S
--
S
R
T
TGNGY
I
T
S
Y
N
D
S
W
Q
H
D
W
A
Y
W
A
N
Y
L
-----
A
A
R
K
M
--------
K
L
G
V
Y
Y
N
P
LW-------------
V
H
R
--
A
A
V
E
D
A
------
S
---
K
T
V
--------
L
G
-
R
-----------
P
D
V
K
I
A
D
L
V
V
P
G
D
F
F
A
R
D
I
G
G
N
Q
L
Y
WLDV
T
K
S
-----------------------------------------------
G
A
K
E
Y
V
Q
G
Y
V
R
Y
F
K
D
L
G
V
---
P
Y
L
R
I
D
-------------------------
F
L
S
W
Y
E
D
G
--
R
D
A
-
N
I
G
Q
V
N
A
P
H
G
-
R
---------
A
N
-
Y
E
L
A
-------
L
S
W
I
N
E
A
A
G
E
D
M
E
-
V
S
--
L
V
---
P
H
M
--
F
Q
D
G
S
A
E
L
A
N
-----
G
D
L
V
--
R
I
N
ADADKGGWDRL
S
G
M
R
Q
N
--
W
--
Q
D
A
W
--
P
N
W
A
N
--
P
F
C
G
F
T
G
---
W
S
H
R
N
G
R
G
Q
---
L
-
I
L
D
G
--
D
F
M
R
A
S
---
T
F
A
S
---
D
--
E
E
----
R
K
--
T
M
M
N
L
M
--
V
A
---
A
G
S
P
L
A
I
A
D
T
-
Y
Q
Q
I
-
G
N
N
A
W
V
---
Y
T
N
---
K
E
V
L
--
Q
L
N
A
D
G
L
V
G
K
P
L
Y
-
R
S
A
T
P
------------
F
S
K
-
D
P
G
------
S
R
D
--
T
E
R
W
A
G
Q
--------
L
P
D
G
S
W
G
V
A
L
F
N
R
---------------
S
D
T
E
T
V
T
K
T
I
D
F
A
K
D
L
G
L
A
T
G
-
G
N
V
R
D
L
-
W
E
-----
H
R
N
L
G
---
M
D
S
R
A
T
-
A
A
L
-
A
-
P
---
H
-
A
S
--
A
-
I
--
F
R
V
T
P
--
P
K
M
H
G
--
T
T
R
Y
P
A
A
FAAWGGG
A
G
F
N
Y
N
H
P
G
Y
DGN
G
F
V
D
G
L
Q
A
-
G
-
S
G
S
A
D
P
L
V
-
T
F
A
V
Q
V
P
H
R
--------
G
-------
S
Y
A
I
R
Y
R
Y
A
-
N
----
A
T
G
D
----
T
-
S
T
M
T
V
T
A
E
K
A
D
R
S
T
V
-
D
G
-----
P
V
H
V
S
F
P
G
L
ATWD
T
W
G
-
V
A
D
G
T
I
T
L
D
A
G
L
N
L
V
T
I
G
R
G
ATD
K
G
A
I
N
L
N
W
I
E
L
DM
37
Fugue
48.99
14%
-50
- C4 -
4UM2
1
EST1A_HUMAN
A:
[1-582]
---------S
M
E
L
H
R
L
L
R
V
A
D
N
Q
E
L
---
Q
--
L
S
--
N
L
L
S
R
----------------------
D
R
-----------------------------------------
I
-
S
P
E
---
G
L
E
K
M
A
Q
L
R
A
-----------------
E
L
L
Q
L
Y
E
---
R
C
I
L
L
D
I
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F
S
D
N
--
Q
--
N
V
D
-----
Q
I
L
W
K
N
A
F
Y
Q
V
I
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R
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L
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DPNV
E
N
P
E
Q
I
R
N
R
-
L
L
E
L
L
D
E
G
S
D
F
---------------
F
D
S
--
L
L
Q
K
L
Q
------
V
---
T
Y
K
---
F
---
K
L
E
-
D
-----------
Y
M
D
G
L
A
I
R
L
R
K
T
V
K
Y
A
L
I
S
A
Q
R
C
M
I
----
C
Q
G
-----------------------------------------------
D
I
A
R
Y
R
E
Q
A
S
D
T
A
--------
N
Y
G
K
A
R
S
---------
W
-------------
Y
L
K
A
Q
H
I
A
P
--
K
N
G
-
R
P
Y
N
Q
L
A
L
L
A
-
V
---------
Y
T
-
R
R
K
L
-------
D
A
V
Y
Y
Y
M
R
S
L
A
A
S
-
N
P
--
I
L
T
A
K
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L
--
M
S
L
F
E
E
T
K
R
K
A
E
Q
M
E
K
G
L
G
--
S
L
S
--------------
P
S
D
--
L
--
N
K
R
F
--
I
L
S
F
-
L
H
A
H
G
K
L
F
T
---
R
I
G
M
E
T
F
P
A
---
V
A
E
K
V
L
--
K
E
F
Q
V
L
---
L
Q
H
S
------------------------------------
P
S
P
-
I
G
---
S
T
R
M
L
Q
---
L
M
T
---
I
N
M
F
--
A
V
H
N
----
S
Q
R
S
V
-
I
Q
E
Q
A
A
A
L
-
G
L
A
-
M
F
S
L
L
-----
V
------
R
R
C
--
T
C
L
L
K
E
S
-
L
------
S
S
P
E
D
--------------------
Q
D
D
Q
D
D
I
K
V
S
S
F
V
P
D
L
K
E
-
L
L
P
S
V
K
V
W
S
D
W
M
-
L
G
-
Y
------------
P
D
T
W
N
-
P
P
P
-
T
-
S
---
L
-
D
L
--
P
-
S
--
H
V
A
V
D
--
V
W
S
T
L
--
A
D
F
C
N
I
L
------------
T
A
V
N
Q
----
S
E
V
P
L
Y
K
-
D
-
P
D
D
D
---
L
-
T
L
L
I
L
E
E
D
R
L
L
SGF
V
P
L
L
-------
A
A
P
Q
D
P
C
Y
V
-
E
----
K
T
S
D
----
K
V
I
A
A
D
C
K
R
V
T
V
L
K
Y
F
L
-
E
A
L
C
G
-
Q
E
------
E
P
------
L
-
L
A
F
K
G
G
K
Y
V
S
V
A
P
V
----------------------
38
Fugue
37.92
15%
10
* C4 *
1UG7
-
AIDA_MOUSE
A:
[1-128]
------------------------------------------------------------------
G
S
S
G
----------------------
S
S
------
G
M
S
E
-
V
-
T
R
S
---
L
L
Q
R
W
G
A
S
L
R
-----------------
R
G
A
D
F
D
S
---
W
----------
G
--
Q
--
L
V
E
-----
A
I
D
E
Y
Q
I
L
A
R
H
L
Q
K
E
A
Q
A
Q
-----
H
N
N
S
E
F
T
E
E
-
Q
K
K
T
I
G
K
I
A
T
C
---------------
L
E
L
--
R
S
A
A
L
Q
STQSQE
E
---
F
K
L
---
E
---
D
L
K
-
K
-----------
L
E
P
I
L
K
N
I
L
T
Y
N
K
E
F
P
F
D
V
Q
P
I
S
G
P
----
S
S
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------