@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0182: (2016-03-13 )
MKQRIGAYLIDAFHRAGVDKIFGVPGDFNLAFLDDIISNPNVDWVGNTNELNASYAADGYARLNGLAALVTTFGVGELSAVNGIAGSYAERIPVIAITGAPTRAVEQAGKYVHHSLGEGTFDDYRKMFAHITVAQGYITPENATTEIPRLINTAIAERRPVHLHLPIDVAISEIEIPTPFEVTATKDTDASTYIELLATKLHQAKQPIIITGHEINSFHLHQELEDFVNQTQIPVAQLSLGKGAFNEENPYYMGIYDGKIAEDKIRDYVDNSDLILNIGAKLTDSATAGFSYQFNIDDVVMLNHHNIKIDDVTNDEISLPSLLKQLSNISYTNSATFPAYHRPTSPDYTVGTEPLTQQTYFKMMQNFLKPNDVIIADQGTSFFGAYDLALYKNNTFIGQPLWGSIGYTLPATLGSQLADKDRRNLLLIGDGSLQLTVQAISTMIRQHIKPVLFVINNDGYTVERLIHGMYEPYNEIHMWDYKALPAVFGGKNVEIHDVESSKDLQDTFNAINGHPDVMHFVEVKMSVEDAPKKLIDIAKAFSQQNK
Atome Classification :
(26 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......-140.-.......150.......-160....---...170......-.180.--...---------...190.---.......200--........210.......220.......230....-...240.......250.......260.......270.......280.......290.......300----.......310------.....-..320.-......-----330.....-..340......---.350.........360.......370.......380.......390....-...400.......410......----.420---........430.......440.......450.......460.......470.......480.......-490.-......----.500....-...---510.......520.......530.......540....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKQ
R
I
G
A
Y
L
I
D
A
F
H
RAG
V
D
K
IFGVPGD
F
N
L
A
F
L
D
D
I
ISNPN
V
D
WVGNTNELNASYAAD
G
Y
A
R
L
N
G
L
A
A
L
V
T
T
FGVG
E
L
S
A
V
N
G
I
A
G
S
Y
AERI
P
V
I
A
ITGA
P
T
R
A
V
E
Q
A
G
K
Y
V
H
H
SLGEG
T
F
D
D
Y
R
K
M
F
A
H
I
T
V
A
Q
G
Y
IT-P-EN-AT
T
E
I
P
R
L
I
N
T
A
I
AERR-
P
V
H
L
H
LP---
I
D
V
A
I
S
EIEIPT-P
F
E
V
T
--ATK---------DT
D
A
-
S
T
---
Y
I
E
L
L
A
T
K
L
---HQAKQ
P
I
I
I
TGHEI
N
S
F
H
L
H
Q
E
L
E
D
F
V
N
QTQI
P
V
A
-
Q
L
SLGKGAFNEEN
P
Y
Y
M
G
I
YDGKI
A
E
D
K
I
R
D
YVDNS
D
L
I
L
NIGAKLTDSATA
G
F
S
Y
Q
FNI
D
D
V
V
M
L
----NHH
N
I
K
I
DDV------TNDEI-
S
L
P
S
L
L
-
K
Q
L
SNI-----SYTNSATF-PAYHRPTSPDY---TV--GTEPL
T
Q
Q
T
Y
F
K
M
M
Q
N
FLKPN
D
V
I
I
ADQGT
S
F
F
G
A
Y
D
L
A
L
YKNNTF-IGQP
L
W
GSIGY
T
L
P
A
T
L
G
S
Q
L
A----DKD----RR
N
L
L
L
IGDG
S
L
Q
L
T
V
Q
A
I
S
T
M
I
R
QHIK
P
V
L
F
V
I
NNDG
Y
T
V
E
R
L
I
H
G
M
YEPYNE
I
H
M
W
D
Y
K
A
L
P
A
VFG-G-KN-
V
E
I
H
DV----ESS
K
D
L
Q
D
-
T
F
N
---AINGHP
D
V
M
H
F
V
E
V
K
MSVEDA
P
K
K
L
I
D
I
A
K
A
F
SQQNK
43
HHSearch
97.90
38%
-87
- C6 -
1OVM
3
DCIP_ENTCL
A:
[4-551]
-
P
Y
C
V
A
D
Y
L
L
D
R
L
T
D
C
G
A
D
H
L
F
G
V
P
G
D
Y
N
L
Q
F
L
D
H
V
I
D
S
P
D
I
C
W
V
G
C
A
N
E
L
N
A
S
Y
A
A
D
G
Y
A
R
C
K
G
F
A
A
L
L
T
T
F
G
V
G
E
L
S
A
M
N
G
I
A
G
S
Y
A
E
H
V
P
V
L
H
I
V
G
A
P
G
T
A
A
Q
Q
R
G
E
L
L
H
H
T
L
G
D
G
E
F
R
H
F
Y
H
M
S
E
P
I
T
V
A
Q
A
V
L
T
-
E
-
Q
N
-
A
C
Y
E
I
D
R
V
L
T
T
M
L
R
E
R
R
-
P
G
Y
L
M
L
P
---
A
D
V
A
K
K
A
A
T
P
P
V
N
A
L
T
H
K
Q
A
H
A
D
---------
S
A
C
L
-
K
A
---
F
R
D
A
A
E
N
K
L
---
A
M
S
K
R
T
A
L
L
A
D
F
L
V
L
R
H
G
L
K
H
A
L
Q
K
W
V
K
E
V
P
M
A
H
A
-
T
M
L
M
G
K
G
I
F
D
E
R
Q
A
G
F
Y
G
T
Y
S
G
S
A
S
T
G
A
V
K
E
A
I
E
G
A
D
T
V
L
C
V
G
T
R
F
T
D
T
L
T
A
G
F
T
H
Q
L
T
P
A
Q
T
I
E
V
----
Q
P
H
A
A
R
V
G
D
V
------
W
F
T
G
I
-
P
M
N
Q
A
I
-
E
T
L
V
E
L
------
C
K
-
Q
H
V
H
A------------------
P
D
G
S
L
T
Q
E
N
F
W
R
T
L
Q
T
F
I
R
P
G
D
I
I
L
A
D
Q
G
T
S
A
F
G
A
I
D
L
R
L
P
A
D
V
N
F
-
I
V
Q
P
L
W
G
S
I
G
Y
T
L
A
A
A
F
G
A
Q
T
A
----
C
P
N
----
R
R
V
I
V
L
T
G
D
G
A
A
Q
L
T
I
Q
E
L
G
S
M
L
R
D
K
Q
H
P
I
I
L
V
L
N
N
E
G
Y
T
V
E
R
A
I
H
G
A
E
Q
R
Y
N
D
I
A
L
W
N
W
T
H
I
P
Q
A
L
S
-
L
-
D
P
Q
S
E
C
W
R
V
----
S
E
A
E
Q
L
A
D
-
V
L
E
---
K
V
A
H
-
H
E
R
L
S
L
I
E
V
M
L
P
K
A
D
I
P
P
L
L
G
A
L
T
K
A
L
E
A
C
N
N
22
PsiBlast_CBE
96.80
39%
-88
- C6 -
1OVM
3
DCIP_ENTCL
C:
[7-550]
----
V
A
D
Y
L
L
D
R
L
T
D
C
G
A
D
H
L
F
G
V
P
G
D
Y
N
L
Q
F
L
D
H
V
I
D
S
P
D
I
C
W
V
G
C
A
N
E
L
N
A
S
Y
A
A
D
G
Y
A
R
C
K
G
F
A
A
L
L
T
T
F
G
V
G
E
L
S
A
M
N
G
I
A
G
S
Y
A
E
H
V
P
V
L
H
I
V
G
A
P
G
T
A
A
Q
Q
R
G
E
L
L
H
H
T
L
G
D
G
E
F
R
H
F
Y
H
M
S
E
P
I
T
V
A
Q
A
V
L
T
-
E
-
Q
N
-
A
C
Y
E
I
D
R
V
L
T
T
M
L
R
E
R
R
-
P
G
Y
L
M
L
P
---
A
D
V
A
K
K
A
A
T
P
P
V
-
N
A
L
T
H
--
K
Q
A
---------
H
A
D
S
-
A
C
LKA
F
R
D
A
A
E
N
K
L
---
A
M
S
K
R
T
A
L
L
A
D
F
L
V
L
R
H
G
L
K
H
A
L
Q
K
W
V
K
E
V
P
M
A
H
A
-
T
M
L
M
G
K
G
I
F
D
E
R
Q
A
G
F
Y
G
T
Y
S
G
S
A
S
T
G
A
V
K
E
A
I
E
G
A
D
T
V
L
C
V
G
T
R
F
T
D
T
L
T
A
G
F
T
H
Q
L
T
P
A
Q
T
I
E
V
----
Q
P
H
A
A
R
V
G
D
V
WFTGIP
M
N
Q
A
I
E
T
L
V
E
L
C
-
K
Q
H
V
H
A
----------------------
P
D
G
---
S
-------
L
T
Q
E
N
F
W
R
T
L
Q
T
F
I
R
P
G
D
I
I
L
A
D
Q
G
T
S
A
F
G
A
I
D
L
R
L
P
A
D
V
N
F
-
I
V
Q
P
L
W
G
S
I
G
Y
T
L
A
A
A
F
G
A
Q
T
A
----
C
P
N
----
R
R
V
I
V
L
T
G
D
G
A
A
Q
L
T
I
Q
E
L
G
S
M
L
R
D
K
Q
H
P
I
I
L
V
L
N
N
E
G
Y
T
V
E
R
A
I
H
G
A
E
Q
R
Y
N
D
I
A
L
W
N
W
T
H
I
P
Q
A
L
S
L
D
-
P
Q
-
S
E
C
W
R
V
----
S
E
A
E
Q
L
A
D
-
V
L
E
---
K
V
-
A
H
H
E
R
L
S
L
I
E
V
M
L
P
K
A
D
I
P
P
L
L
G
A
L
T
K
A
L
E
A
C
N
-
1
PsiBlast_PDB
96.49
39%
-88
- C6 -
1OVM
3
DCIP_ENTCL
A:
[7-550]
----
V
A
D
Y
L
L
D
R
L
T
D
C
G
A
D
H
L
F
G
V
P
G
D
Y
N
L
Q
F
L
D
H
V
I
D
S
P
D
I
C
W
V
G
C
A
N
E
L
N
A
S
Y
A
A
D
G
Y
A
R
C
K
G
F
A
A
L
L
T
T
F
G
V
G
E
L
S
A
M
N
G
I
A
G
S
Y
A
E
H
V
P
V
L
H
I
V
G
A
P
G
T
A
A
Q
Q
R
G
E
L
L
H
H
T
L
G
D
G
E
F
R
H
F
Y
H
M
S
E
P
I
T
V
A
Q
A
V
L
T
-
E
-
Q
N
-
A
C
Y
E
I
D
R
V
L
T
T
M
L
R
E
R
R
-
P
G
Y
L
M
L
P
---
A
D
V
A
K
K
A
A
T
P
P
V
-
N
A
L
T
H
--
K
Q
A
---------
H
A
D
S
-
A
C
L
K
A
F
R
D
A
A
E
N
K
L
---
A
M
S
K
R
T
A
L
L
A
D
F
L
V
L
R
H
G
L
K
H
A
L
Q
K
W
V
K
E
V
P
M
A
H
A
-
T
M
L
M
G
K
G
I
F
D
E
R
Q
A
G
F
Y
G
T
Y
S
G
S
A
S
T
G
A
V
K
E
A
I
E
G
A
D
T
V
L
C
V
G
T
R
F
T
D
T
L
T
A
G
F
T
H
Q
L
T
P
A
Q
T
I
E
V
----
Q
P
H
A
A
R
V
G
D
V
W
F
T
GIP
M
N
Q
A
I
E
T
L
V
E
L
C
-
K
Q
H
V
H
A
----------------------
P
D
G
---
S
-------
L
T
Q
E
N
F
W
R
T
L
Q
T
F
I
R
P
G
D
I
I
L
A
D
Q
G
T
S
A
F
G
A
I
D
L
R
L
P
A
D
V
N
F
-
I
V
Q
P
L
W
G
S
I
G
Y
T
L
A
A
A
F
G
A
Q
T
A
----
C
P
N
----
R
R
V
I
V
L
T
G
D
G
A
A
Q
L
T
I
Q
E
L
G
S
M
L
R
D
K
Q
H
P
I
I
L
V
L
N
N
E
G
Y
T
V
E
R
A
I
H
G
A
E
Q
R
Y
N
D
I
A
L
W
N
W
T
H
I
P
Q
A
L
S
L
D
-
P
Q
-
S
E
C
W
R
V
----
S
E
A
E
Q
L
A
D
-
V
L
E
---
K
V
-
A
H
H
E
R
L
S
L
I
E
V
M
L
P
K
A
D
I
P
P
L
L
G
A
L
T
K
A
L
E
A
C
N
-
30
PsiBlast_CBE
95.92
39%
-83
- C6 -
2VK8
4
PDC1_YEAST
D:
[6-560]
----
L
G
K
Y
L
F
E
R
L
K
Q
V
N
V
N
T
V
F
G
L
P
G
D
F
N
L
S
L
L
D
K
I
Y
E
V
E
G
M
R
W
A
G
N
A
N
E
L
N
A
A
Y
A
A
D
G
Y
A
R
I
K
G
M
S
C
I
I
T
T
F
G
V
G
E
L
S
A
L
N
G
I
A
G
S
Y
A
E
H
V
G
V
L
H
V
V
G
V
P
S
I
S
A
Q
A
K
Q
L
L
L
H
H
T
L
G
N
G
D
F
T
V
F
H
R
M
S
A
N
I
S
E
T
T
A
M
I
T
-
D
I
A
T
-
A
P
A
E
I
D
R
C
I
R
T
T
Y
V
T
Q
R
-
P
V
Y
L
G
L
P
ANL
V
D
L
N
V
P
A
K
L
L
Q
T
-
P
I
D
M
S
---
L
K
---------
P
N
D
A
-
E
S
---
E
K
E
V
I
D
T
I
L
VLD
K
D
A
K
N
P
V
I
L
A
D
A
C
C
S
R
H
D
V
K
A
E
T
K
K
L
I
D
L
T
Q
F
P
A
F
-
V
T
P
M
G
K
G
S
I
D
E
Q
H
P
R
Y
G
G
V
Y
V
G
T
L
S
K
P
E
V
K
E
A
V
E
S
A
D
L
I
L
S
V
G
A
L
L
S
D
F
N
T
G
S
F
S
Y
S
Y
K
T
K
N
I
V
E
F
----
H
S
D
H
M
K
I
R
N
A
------
T
F
P
G
V
-
Q
M
K
F
V
L
Q
K
L
L
T
T
I
-----
A
D
A
A
K
G
Y
K
-
P
V
A
V
P
A
R
T
P
A
N
---
A
A
VP
A
S
T
P
L
K
Q
E
W
M
W
N
Q
L
G
N
F
L
Q
E
G
D
V
V
I
A
E
T
G
T
S
A
F
G
-
I
N
Q
T
T
F
P
N
N
T
Y
G
I
S
Q
V
L
W
G
S
I
G
F
T
T
G
A
T
L
G
A
A
F
A
AEEI
D
P
K
----
K
R
V
I
L
F
I
G
D
G
S
L
Q
L
T
V
Q
E
I
S
T
M
I
R
W
G
L
K
P
Y
L
F
V
L
N
N
D
G
Y
T
I
Q
K
L
I
H
G
P
K
A
Q
Y
N
E
I
Q
G
W
D
H
L
S
L
L
P
T
F
G
-
A
-
K
D
-
Y
E
T
H
R
V
ATTG
E
W
D
K
L
T
Q
D
---
K
---
S
F
N
D
N
S
K
I
-
R
M
I
E
V
M
L
P
V
F
D
A
P
Q
N
L
V
E
Q
A
K
L
T
A
A
T
N
-
39
PsiBlast_CBE
95.56
37%
-87
- C6 -
2VJY
6
PDC1_KLULA
D:
[6-560]
----
L
G
R
Y
L
F
E
R
L
K
Q
V
E
V
Q
T
I
F
G
L
P
G
D
F
N
L
S
L
L
D
N
I
Y
E
V
P
G
M
R
W
A
G
N
A
N
E
L
N
A
A
Y
A
A
D
G
Y
A
R
L
K
G
M
S
C
I
I
T
T
F
G
V
G
E
L
S
A
L
N
G
I
A
G
S
Y
A
E
H
V
G
V
L
H
V
V
G
V
P
S
V
S
S
Q
A
K
Q
L
L
L
H
H
T
L
G
N
G
D
F
T
V
F
H
R
M
S
S
N
I
S
E
T
T
A
M
I
T
-
D
-
I
N
T
A
P
A
E
I
D
R
C
I
R
T
T
Y
V
S
Q
R
-
P
V
Y
L
G
L
P
ANL
V
D
L
T
V
P
A
S
L
L
D
T
-
P
I
D
L
S
L-
K
P
N
---------
D
P
E
A
E
E
E
---
V
I
E
N
V
L
Q
L
I
---
K
E
A
K
N
P
V
I
L
A
D
A
C
C
S
R
H
D
A
K
A
E
T
K
K
L
I
D
L
T
Q
F
P
A
F
-
V
T
P
M
G
K
G
S
I
D
E
K
H
P
R
F
G
G
V
Y
V
G
T
L
S
S
P
A
V
K
E
A
V
E
S
A
D
L
V
L
S
V
G
A
L
L
S
D
F
N
T
G
S
F
S
Y
S
Y
K
T
K
N
I
V
E
F
----
H
S
D
Y
T
K
I
R
S
A
------
T
F
P
G
V
-
Q
M
K
F
A
L
-
Q
K
L
L
T
K
-----
V
A
D
A
A
K
G
Y
-
K
P
V
P
V
P
S
E
P
E
H
NEA
V
A
--
D
S
T
P
L
K
Q
E
W
V
W
T
Q
V
G
E
F
L
R
E
G
D
V
V
I
T
E
T
G
T
S
A
F
G
-
I
N
Q
T
H
F
P
N
N
T
Y
G
I
S
Q
V
L
W
G
S
I
G
F
T
T
G
A
T
L
G
A
A
F
A
AEEI
D
P
K
----
K
R
V
I
L
F
I
G
D
G
S
L
Q
L
T
V
Q
E
I
S
T
M
I
R
W
G
L
K
P
Y
L
F
V
L
N
N
D
G
Y
T
I
E
R
L
I
H
G
E
T
A
Q
Y
N
C
I
Q
N
W
Q
H
L
E
L
L
P
T
F
G
-
A
-
K
D
-
Y
E
A
V
R
V
----
S
T
T
G
E
W
N
K
L
T
T
D
---
E
K
F
Q
D
N
T
R
I
R
L
I
E
V
M
L
P
T
M
D
A
P
S
N
L
V
K
Q
A
Q
L
T
A
A
T
N
-
32
PsiBlast_CBE
95.49
39%
-84
- C6 -
2VK8
4
PDC1_YEAST
B:
[6-560]
----
L
G
K
Y
L
F
E
R
L
K
Q
V
N
V
N
T
V
F
G
L
P
G
D
F
N
L
S
L
L
D
K
I
Y
E
V
E
G
M
R
W
A
G
N
A
N
E
L
N
A
A
Y
A
A
D
G
Y
A
R
I
K
G
M
S
C
I
I
T
T
F
G
V
G
E
L
S
A
L
N
G
I
A
G
S
Y
A
E
H
V
G
V
L
H
V
V
G
V
P
S
I
S
A
Q
A
K
Q
L
L
L
H
H
T
L
G
N
G
D
F
T
V
F
H
R
M
S
A
N
I
S
E
T
T
A
M
I
T
-
D
I
A
T
-
A
P
A
E
I
D
R
C
I
R
T
T
Y
V
T
Q
R
-
P
V
Y
L
G
L
P
ANL
V
D
L
N
V
P
A
K
L
L
Q
T
-
P
I
D
M
S
---
L
K
---------
P
N
D
A
-
E
S
---
E
K
E
V
I
D
T
I
L
VLD
K
D
A
K
N
P
V
I
L
A
D
A
C
C
S
R
H
D
V
K
A
E
T
K
K
L
I
D
L
T
Q
F
P
A
F
-
V
T
P
M
G
K
G
S
I
D
E
Q
H
P
R
Y
G
G
V
Y
V
G
T
L
S
K
P
E
V
K
E
A
V
E
S
A
D
L
I
L
S
V
G
A
L
L
S
D
F
N
T
G
S
F
S
Y
S
Y
K
T
K
N
I
V
E
F
----
H
S
D
H
M
K
I
R
N
A
------
T
F
P
G
V
-
Q
M
K
F
V
L
Q
K
L
L
T
T
I
-----
A
D
A
A
K
G
Y
K
-
P
V
A
V
P
A
R
T
P
A
N
---
A
A
VP
A
S
T
P
L
K
Q
E
W
M
W
N
Q
L
G
N
F
L
Q
E
G
D
V
V
I
A
E
T
G
T
S
A
F
G
-
I
N
Q
T
T
F
P
N
N
T
Y
G
I
S
Q
V
L
W
G
S
I
G
F
T
T
G
A
T
L
G
A
A
F
A
AEEI
D
P
K
----
K
R
V
I
L
F
I
G
D
G
S
L
Q
L
T
V
Q
E
I
S
T
M
I
R
W
G
L
K
P
Y
L
F
V
L
N
N
D
G
Y
T
I
Q
K
L
I
H
G
P
K
A
Q
Y
N
E
I
Q
G
W
D
H
L
S
L
L
P
T
F
G
-
A
-
K
D
-
Y
E
T
H
R
V
ATTG
E
W
D
K
L
T
Q
D
---
K
---
S
F
N
D
N
S
K
I
-
R
M
I
E
V
M
L
P
V
F
D
A
P
Q
N
L
V
E
Q
A
K
L
T
A
A
T
N
-
23
PsiBlast_CBE
95.48
39%
-87
- C6 -
1OVM
3
DCIP_ENTCL
B:
[7-550]
----
V
A
D
Y
L
L
D
R
L
T
D
C
G
A
D
H
L
F
G
V
P
G
D
Y
N
L
Q
F
L
D
H
V
I
D
S
P
D
I
C
W
V
G
C
A
N
E
L
N
A
S
Y
A
A
D
G
Y
A
R
C
K
G
F
A
A
L
L
T
T
F
G
V
G
E
L
S
A
M
N
G
I
A
G
S
Y
A
E
H
V
P
V
L
H
I
V
G
A
P
G
T
A
A
Q
Q
R
G
E
L
L
H
H
T
L
G
D
G
E
F
R
H
F
Y
H
M
S
E
P
I
T
V
A
Q
A
V
L
T
-
E
-
Q
N
-
A
C
Y
E
I
D
R
V
L
T
T
M
L
R
E
R
R
-
P
G
Y
L
M
L
P
---
A
D
V
A
K
K
A
A
T
P
P
V
-
N
A
L
T
H
--
K
Q
A
---------
H
A
D
S
-
A
C
LKA
F
R
D
A
A
E
N
K
L
---
A
M
S
K
R
T
A
L
L
A
D
F
L
V
L
R
H
G
L
K
H
A
L
Q
K
W
V
K
E
V
P
M
A
H
A
-
T
M
L
M
G
K
G
I
F
D
E
R
Q
A
G
F
Y
G
T
Y
S
G
S
A
S
T
G
A
V
K
E
A
I
E
G
A
D
T
V
L
C
V
G
T
R
F
T
D
T
L
T
A
G
F
T
H
Q
L
T
P
A
Q
T
I
E
V
----
Q
P
H
A
A
R
V
G
D
V
WFTGIP
M
N
Q
A
I
E
T
L
V
E
L
C
-
K
Q
H
V
H
A
----------------------
P
D
G
---
S
-------
L
T
Q
E
N
F
W
R
T
L
Q
T
F
I
R
P
G
D
I
I
L
A
D
Q
G
T
S
A
F
G
A
I
D
L
R
L
P
A
D
V
N
F
-
I
V
Q
P
L
W
G
S
I
G
Y
T
L
A
A
A
F
G
A
Q
T
A
----
C
P
N
----
R
R
V
I
V
L
T
G
D
G
A
A
Q
L
T
I
Q
E
L
G
S
M
L
R
D
K
Q
H
P
I
I
L
V
L
N
N
E
G
Y
T
V
E
R
A
I
H
G
A
E
Q
R
Y
N
D
I
A
L
W
N
W
T
H
I
P
Q
A
L
S
L
D
-
P
Q
-
S
E
C
W
R
V
----
S
E
A
E
Q
L
A
D
-
V
L
E
---
K
V
-
A
H
H
E
R
L
S
L
I
E
V
M
L
P
K
A
D
I
P
P
L
L
G
A
L
T
K
A
L
E
A
C
N
-
21
PsiBlast_CBE
95.40
39%
-86
- C6 -
1OVM
3
DCIP_ENTCL
D:
[7-550]
----
V
A
D
Y
L
L
D
R
L
T
D
C
G
A
D
H
L
F
G
V
P
G
D
Y
N
L
Q
F
L
D
H
V
I
D
S
P
D
I
C
W
V
G
C
A
N
E
L
N
A
S
Y
A
A
D
G
Y
A
R
C
K
G
F
A
A
L
L
T
T
F
G
V
G
E
L
S
A
M
N
G
I
A
G
S
Y
A
E
H
V
P
V
L
H
I
V
G
A
P
G
T
A
A
Q
Q
R
G
E
L
L
H
H
T
L
G
D
G
E
F
R
H
F
Y
H
M
S
E
P
I
T
V
A
Q
A
V
L
T
-
E
-
Q
N
-
A
C
Y
E
I
D
R
V
L
T
T
M
L
R
E
R
R
-
P
G
Y
L
M
L
P
---
A
D
V
A
K
K
A
A
T
P
P
V
-
N
A
L
T
H
--
K
Q
A
---------
H
A
D
S
-
A
C
LKA
F
R
D
A
A
E
N
K
L
---
A
M
S
K
R
T
A
L
L
A
D
F
L
V
L
R
H
G
L
K
H
A
L
Q
K
W
V
K
E
V
P
M
A
H
A
-
T
M
L
M
G
K
G
I
F
D
E
R
Q
A
G
F
Y
G
T
Y
S
G
S
A
S
T
G
A
V
K
E
A
I
E
G
A
D
T
V
L
C
V
G
T
R
F
T
D
T
L
T
A
G
F
T
H
Q
L
T
P
A
Q
T
I
E
V
----
Q
P
H
A
A
R
V
G
D
V
WFTGIP
M
N
Q
A
I
E
T
L
V
E
L
C
-
K
Q
H
V
H
A
----------------------
P
D
G
---
S
-------
L
T
Q
E
N
F
W
R
T
L
Q
T
F
I
R
P
G
D
I
I
L
A
D
Q
G
T
S
A
F
G
A
I
D
L
R
L
P
A
D
V
N
F
-
I
V
Q
P
L
W
G
S
I
G
Y
T
L
A
A
A
F
G
A
Q
T
A
----
C
P
N
----
R
R
V
I
V
L
T
G
D
G
A
A
Q
L
T
I
Q
E
L
G
S
M
L
R
D
K
Q
H
P
I
I
L
V
L
N
N
E
G
Y
T
V
E
R
A
I
H
G
A
E
Q
R
Y
N
D
I
A
L
W
N
W
T
H
I
P
Q
A
L
S
L
D
-
P
Q
-
S
E
C
W
R
V
----
S
E
A
E
Q
L
A
D
-
V
L
E
---
K
V
-
A
H
H
E
R
L
S
L
I
E
V
M
L
P
K
A
D
I
P
P
L
L
G
A
L
T
K
A
L
E
A
C
N
-
35
PsiBlast_CBE
95.39
39%
-84
- C6 -
2VK1
6
PDC1_YEAST
B:
[6-560]
----
L
G
K
Y
L
F
E
R
L
K
Q
V
N
V
N
T
V
F
G
L
P
G
A
F
N
L
S
L
L
D
K
I
Y
E
V
E
G
M
R
W
A
G
N
A
N
E
L
N
A
A
Y
A
A
D
G
Y
A
R
I
K
G
M
S
C
I
I
T
T
F
G
V
G
E
L
S
A
L
N
G
I
A
G
S
Y
A
E
H
V
G
V
L
H
V
V
G
V
P
S
I
S
A
Q
A
K
Q
L
L
L
H
H
T
L
G
N
G
D
F
T
V
F
H
R
M
S
A
N
I
S
E
T
T
A
M
I
T
-
D
I
A
T
-
A
P
A
E
I
D
R
C
I
R
T
T
Y
V
T
Q
R
-
P
V
Y
L
G
L
P
ANL
V
D
L
N
V
P
A
K
L
L
Q
T
-
P
I
D
M
S
---
L
K
---------
P
N
D
A
-
E
S
---
E
K
E
V
I
D
T
I
L
VLD
K
D
A
K
N
P
V
I
L
A
D
A
C
C
S
R
H
D
V
K
A
E
T
K
K
L
I
D
L
T
Q
F
P
A
F
-
V
T
P
M
G
K
G
S
I
D
E
Q
H
P
R
Y
G
G
V
Y
V
G
T
L
S
K
P
E
V
K
E
A
V
E
S
A
D
L
I
L
S
V
G
A
L
L
S
D
F
N
T
G
S
F
S
Y
S
Y
K
T
K
N
I
V
E
F
----
H
S
D
H
M
K
I
R
N
A
------
T
F
P
G
V
-
Q
M
K
F
V
L
Q
K
L
L
T
A
I
-----
A
D
A
A
K
G
Y
K
-
P
V
A
V
P
A
R
T
P
A
N
---
A
A
VP
A
S
T
P
L
K
Q
E
W
M
W
N
Q
L
G
N
F
L
Q
E
G
D
V
V
I
A
E
T
G
T
S
A
F
G
-
I
N
Q
T
T
F
P
N
N
T
Y
G
I
S
Q
V
L
W
G
S
I
G
F
T
T
G
A
T
L
G
A
A
F
A
AEEI
D
P
K
----
K
R
V
I
L
F
I
G
D
G
S
L
Q
L
T
V
Q
E
I
S
T
M
I
R
W
G
L
K
P
Y
L
F
V
L
N
N
D
G
Y
T
I
E
K
L
I
H
G
P
K
A
Q
Y
N
E
I
Q
G
W
D
H
L
S
L
L
P
T
F
G
-
A
-
K
D
-
Y
E
T
H
R
V
ATTG
E
W
D
K
L
T
Q
D
K
S
F
N
-------
D
N
S
K
I
R
M
I
E
V
M
L
P
V
F
D
A
P
Q
N
L
V
E
Q
A
K
L
T
A
A
T
N
-
24
PsiBlast_CBE
95.26
39%
-84
- C6 -
2W93
6
PDC1_YEAST
D:
[6-560]
----
L
G
K
Y
L
F
E
R
L
K
Q
V
N
V
N
T
V
F
G
L
P
G
D
F
N
L
S
L
L
D
K
I
Y
E
V
E
G
M
R
W
A
G
N
A
N
E
L
N
A
A
Y
A
A
D
G
Y
A
R
I
K
G
M
S
C
I
I
T
T
F
G
V
G
E
L
S
A
L
N
G
I
A
G
S
Y
A
E
H
V
G
V
L
H
V
V
G
V
P
S
I
S
S
Q
A
K
Q
L
L
L
H
H
T
L
G
N
G
D
F
T
V
F
H
R
M
S
A
N
I
S
E
T
T
A
M
I
T
-
D
I
A
T
-
A
P
A
E
I
D
R
C
I
R
T
T
Y
V
T
Q
R
-
P
V
Y
L
G
L
P
ANL
V
D
L
N
V
P
A
K
L
L
Q
T
-
P
I
D
M
S
---
L
K
---------
P
N
D
A
-
E
S
---
E
K
E
V
I
D
T
I
L
ALV
K
D
A
K
N
P
V
I
L
A
D
A
C
C
S
R
H
D
V
K
A
E
T
K
K
L
I
D
L
T
Q
F
P
A
F
-
V
T
P
M
G
K
G
S
I
D
E
Q
H
P
R
Y
G
G
V
Y
V
G
T
L
S
K
P
E
V
K
E
A
V
E
S
A
D
L
I
L
S
V
G
A
L
L
S
D
F
N
T
G
S
F
S
Y
S
Y
K
T
K
N
I
V
E
F
----
H
S
D
H
M
K
I
R
N
A
------
T
F
P
G
V
-
Q
M
K
F
V
L
Q
K
L
L
T
N
I
-----
A
D
A
A
K
G
Y
K
-
P
V
A
V
P
A
R
T
P
A
N
---
A
A
VP
A
S
T
P
L
K
Q
E
W
M
W
N
Q
L
G
N
F
L
Q
E
G
D
V
V
I
A
E
T
G
T
S
A
F
G
-
I
N
Q
T
T
F
P
N
N
T
Y
G
I
S
Q
V
L
W
G
S
I
G
F
T
T
G
A
T
L
G
A
A
F
A
AEEI
D
P
K
----
K
R
V
I
L
F
I
G
D
G
S
L
Q
L
T
V
Q
E
I
S
T
M
I
R
W
G
L
K
P
Y
L
F
V
L
N
N
D
G
Y
T
I
Q
K
L
I
H
G
P
K
A
Q
Y
N
E
I
Q
G
W
D
H
L
S
L
L
P
T
F
G
-
A
-
K
D
-
Y
E
T
H
R
V
ATTG
E
W
D
K
L
T
Q
D
---
K
---
S
F
N
D
N
S
K
I
-
R
M
I
E
V
M
L
P
V
F
D
A
P
Q
N
L
V
E
Q
A
K
L
T
A
A
T
N
-
7
PsiBlast_PDB
95.22
37%
-89
- C6 -
2VJY
7
PDC1_KLULA
A:
[6-560]
----
L
G
R
Y
L
F
E
R
L
K
Q
V
E
V
Q
T
I
F
G
L
P
G
D
F
N
L
S
L
L
D
N
I
Y
E
V
P
G
M
R
W
A
G
N
A
N
E
L
N
A
A
Y
A
A
D
G
Y
A
R
L
K
G
M
S
C
I
I
T
T
F
G
V
G
E
L
S
A
L
N
G
I
A
G
S
Y
A
E
H
V
G
V
L
H
V
V
G
V
P
S
V
S
S
Q
A
K
Q
L
L
L
H
H
T
L
G
N
G
D
F
T
V
F
H
R
M
S
S
N
I
S
E
T
T
A
M
I
T
-
D
-
I
N
T
A
P
A
E
I
D
R
C
I
R
T
T
Y
V
S
Q
R
-
P
V
Y
L
G
L
P
A
N
L
V
D
L
T
V
P
A
S
L
L
D
T
-
P
I
D
L
S
L-
K
P
N
---------
D
P
E
A
E
E
E
---
V
I
E
N
V
L
Q
L
I
---
K
E
A
K
N
P
V
I
L
A
D
A
C
C
S
R
H
D
A
K
A
E
T
K
K
L
I
D
L
T
Q
F
P
A
F
-
V
T
P
M
G
K
G
S
I
D
E
K
H
P
R
F
G
G
V
Y
V
G
T
L
S
S
P
A
V
K
E
A
V
E
S
A
D
L
V
L
S
V
G
A
L
L
S
D
F
N
T
G
S
F
S
Y
S
Y
K
T
K
N
I
V
E
F
----
H
S
D
Y
T
K
I
R
S
A
------
T
F
P
G
V
-
Q
M
K
F
A
L
-
Q
K
L
L
T
K
-----
V
A
D
A
A
K
G
Y
-
K
P
V
P
V
P
S
E
P
E
H
NEA
V
A
--
D
S
T
P
L
K
Q
E
W
V
W
T
Q
V
G
E
F
L
R
E
G
D
V
V
I
T
E
T
G
T
S
A
F
G
-
I
N
Q
T
H
F
P
N
N
T
Y
G
I
S
Q
V
L
W
G
S
I
G
F
T
T
G
A
T
L
G
A
A
F
A
A
E
E
I
D
P
K
----
K
R
V
I
L
F
I
G
D
G
S
L
Q
L
T
V
Q
E
I
S
T
M
I
R
W
G
L
K
P
Y
L
F
V
L
N
N
D
G
Y
T
I
E
R
L
I
H
G
E
T
A
Q
Y
N
C
I
Q
N
W
Q
H
L
E
L
L
P
T
F
G
-
A
-
K
D
-
Y
E
A
V
R
V
----
S
T
T
G
E
W
N
K
L
T
T
D
---
E
K
F
Q
D
N
T
R
I
R
L
I
E
V
M
L
P
T
M
D
A
P
S
N
L
V
K
Q
A
Q
L
T
A
A
T
N
-
31
PsiBlast_CBE
94.98
39%
-84
- C6 -
2VK8
4
PDC1_YEAST
C:
[6-560]
----
L
G
K
Y
L
F
E
R
L
K
Q
V
N
V
N
T
V
F
G
L
P
G
D
F
N
L
S
L
L
D
K
I
Y
E
V
E
G
M
R
W
A
G
N
A
N
E
L
N
A
A
Y
A
A
D
G
Y
A
R
I
K
G
M
S
C
I
I
T
T
F
G
V
G
E
L
S
A
L
N
G
I
A
G
S
Y
A
E
H
V
G
V
L
H
V
V
G
V
P
S
I
S
A
Q
A
K
Q
L
L
L
H
H
T
L
G
N
G
D
F
T
V
F
H
R
M
S
A
N
I
S
E
T
T
A
M
I
T
-
D
I
A
T
-
A
P
A
E
I
D
R
C
I
R
T
T
Y
V
T
Q
R
-
P
V
Y
L
G
L
P
ANL
V
D
L
N
V
P
A
K
L
L
Q
T
-
P
I
D
M
S
---
L
K
---------
P
N
D
A
-
E
S
---
E
K
E
V
I
D
T
I
L
VLD
K
D
A
K
N
P
V
I
L
A
D
A
C
C
S
R
H
D
V
K
A
E
T
K
K
L
I
D
L
T
Q
F
P
A
F
-
V
T
P
M
G
K
G
S
I
D
E
Q
H
P
R
Y
G
G
V
Y
V
G
T
L
S
K
P
E
V
K
E
A
V
E
S
A
D
L
I
L
S
V
G
A
L
L
S
D
F
N
T
G
S
F
S
Y
S
Y
K
T
K
N
I
V
E
F
----
H
S
D
H
M
K
I
R
N
A
------
T
F
P
G
V
-
Q
M
K
F
V
L
Q
K
L
L
T
T
I
-----
A
D
A
A
K
G
Y
K
-
P
V
A
V
P
A
R
T
P
A
N
---
A
A
VP
A
S
T
P
L
K
Q
E
W
M
W
N
Q
L
G
N
F
L
Q
E
G
D
V
V
I
A
E
T
G
T
S
A
F
G
-
I
N
Q
T
T
F
P
N
N
T
Y
G
I
S
Q
V
L
W
G
S
I
G
F
T
T
G
A
T
L
G
A
A
F
A
AEEI
D
P
K
----
K
R
V
I
L
F
I
G
D
G
S
L
Q
L
T
V
Q
E
I
S
T
M
I
R
W
G
L
K
P
Y
L
F
V
L
N
N
D
G
Y
T
I
Q
K
L
I
H
G
P
K
A
Q
Y
N
E
I
Q
G
W
D
H
L
S
L
L
P
T
F
G
-
A
-
K
D
-
Y
E
T
H
R
V
ATTG
E
W
D
K
L
T
Q
D
---
K
---
S
F
N
D
N
S
K
I
-
R
M
I
E
V
M
L
P
V
F
D
A
P
Q
N
L
V
E
Q
A
K
L
T
A
A
T
N
-
26
PsiBlast_CBE
94.95
39%
-84
- C6 -
2W93
5
PDC1_YEAST
B:
[6-560]
----
L
G
K
Y
L
F
E
R
L
K
Q
V
N
V
N
T
V
F
G
L
P
G
D
F
N
L
S
L
L
D
K
I
Y
E
V
E
G
M
R
W
A
G
N
A
N
E
L
N
A
A
Y
A
A
D
G
Y
A
R
I
K
G
M
S
C
I
I
T
T
F
G
V
G
E
L
S
A
L
N
G
I
A
G
S
Y
A
E
H
V
G
V
L
H
V
V
G
V
P
S
I
S
S
Q
A
K
Q
L
L
L
H
H
T
L
G
N
G
D
F
T
V
F
H
R
M
S
A
N
I
S
E
T
T
A
M
I
T
-
D
I
A
T
-
A
P
A
E
I
D
R
C
I
R
T
T
Y
V
T
Q
R
-
P
V
Y
L
G
L
P
ANL
V
D
L
N
V
P
A
K
L
L
Q
T
-
P
I
D
M
S
---
L
K
---------
P
N
D
A
-
E
S
---
E
K
E
V
I
D
T
I
L
A
L
V
K
D
A
K
N
P
V
I
L
A
D
A
C
C
S
R
H
D
V
K
A
E
T
K
K
L
I
D
L
T
Q
F
P
A
F
-
V
T
P
M
G
K
G
S
I
D
E
Q
H
P
R
Y
G
G
V
Y
V
G
T
L
S
K
P
E
V
K
E
A
V
E
S
A
D
L
I
L
S
V
G
A
L
L
S
D
F
N
T
G
S
F
S
Y
S
Y
K
T
K
N
I
V
E
F
----
H
S
D
H
M
K
I
R
N
A
------
T
F
P
G
V
-
Q
M
K
F
V
L
Q
K
L
L
T
N
I
-----
A
D
A
A
K
G
Y
K
-
P
V
A
V
P
A
R
T
P
A
N
---
A
A
VP
A
S
T
P
L
K
Q
E
W
M
W
N
Q
L
G
N
F
L
Q
E
G
D
V
V
I
A
E
T
G
T
S
A
F
G
-
I
N
Q
T
T
F
P
N
N
T
Y
G
I
S
Q
V
L
W
G
S
I
G
F
T
T
G
A
T
L
G
A
A
F
A
A
E
E
I
D
P
K
----
K
R
V
I
L
F
I
G
D
G
S
L
Q
L
T
V
Q
E
I
S
T
M
I
R
W
G
L
K
P
Y
L
F
V
L
N
N
D
G
Y
T
I
Q
K
L
I
H
G
P
K
A
Q
Y
N
E
I
Q
G
W
D
H
L
S
L
L
P
T
F
G
-
A
-
K
D
-
Y
E
T
H
R
V
AT
T
G
E
W
D
K
L
T
Q
D
---
K
---
S
F
N
D
N
S
K
I
-
R
M
I
E
V
M
L
P
V
F
D
A
P
Q
N
L
V
E
Q
A
K
L
T
A
A
T
N
-
41
PsiBlast_CBE
94.71
37%
-85
- C6 -
2VJY
7
PDC1_KLULA
B:
[6-560]
----
L
G
R
Y
L
F
E
R
L
K
Q
V
E
V
Q
T
I
F
G
L
P
G
D
F
N
L
S
L
L
D
N
I
Y
E
V
P
G
M
R
W
A
G
N
A
N
E
L
N
A
A
Y
A
A
D
G
Y
A
R
L
K
G
M
S
C
I
I
T
T
F
G
V
G
E
L
S
A
L
N
G
I
A
G
S
Y
A
E
H
V
G
V
L
H
V
V
G
V
P
S
V
S
S
Q
A
K
Q
L
L
L
H
H
T
L
G
N
G
D
F
T
V
F
H
R
M
S
S
N
I
S
E
T
T
A
M
I
T
-
D
-
I
N
T
A
P
A
E
I
D
R
C
I
R
T
T
Y
V
S
Q
R
-
P
V
Y
L
G
L
P
ANL
V
D
L
T
V
P
A
S
L
L
D
T
-
P
I
D
L
S
L-
K
P
N
---------
D
P
E
A
E
E
E
---
V
I
E
N
V
L
Q
L
I
---
K
E
A
K
N
P
V
I
L
A
D
A
C
C
S
R
H
D
A
K
A
E
T
K
K
L
I
D
L
T
Q
F
P
A
F
-
V
T
P
M
G
K
G
S
I
D
E
K
H
P
R
F
G
G
V
Y
V
G
T
L
S
S
P
A
V
K
E
A
V
E
S
A
D
L
V
L
S
V
G
A
L
L
S
D
F
N
T
G
S
F
S
Y
S
Y
K
T
K
N
I
V
E
F
----
H
S
D
Y
T
K
I
R
S
A
------
T
F
P
G
V
-
Q
M
K
F
A
L
-
Q
K
L
L
T
K
-----
V
A
D
A
A
K
G
Y
-
K
P
V
P
V
P
S
E
P
E
H
NEA
V
A
--
D
S
T
P
L
K
Q
E
W
V
W
T
Q
V
G
E
F
L
R
E
G
D
V
V
I
T
E
T
G
T
S
A
F
G
-
I
N
Q
T
H
F
P
N
N
T
Y
G
I
S
Q
V
L
W
G
S
I
G
F
T
T
G
A
T
L
G
A
A
F
A
AEEI
D
P
K
----
K
R
V
I
L
F
I
G
D
G
S
L
Q
L
T
V
Q
E
I
S
T
M
I
R
W
G
L
K
P
Y
L
F
V
L
N
N
D
G
Y
T
I
E
R
L
I
H
G
E
T
A
Q
Y
N
C
I
Q
N
W
Q
H
L
E
L
L
P
T
F
G
-
A
-
K
D
-
Y
E
A
V
R
V
----
S
T
T
G
E
W
N
K
L
T
T
D
---
E
K
F
Q
D
N
T
R
I
R
L
I
E
V
M
L
P
T
M
D
A
P
S
N
L
V
K
Q
A
Q
L
T
A
A
T
N
-
34
PsiBlast_CBE
94.65
39%
-84
- C6 -
2VK1
6
PDC1_YEAST
C:
[6-560]
----
L
G
K
Y
L
F
E
R
L
K
Q
V
N
V
N
T
V
F
G
L
P
G
A
F
N
L
S
L
L
D
K
I
Y
E
V
E
G
M
R
W
A
G
N
A
N
E
L
N
A
A
Y
A
A
D
G
Y
A
R
I
K
G
M
S
C
I
I
T
T
F
G
V
G
E
L
S
A
L
N
G
I
A
G
S
Y
A
E
H
V
G
V
L
H
V
V
G
V
P
S
I
S
A
Q
A
K
Q
L
L
L
H
H
T
L
G
N
G
D
F
T
V
F
H
R
M
S
A
N
I
S
E
T
T
A
M
I
T
-
D
I
A
T
-
A
P
A
E
I
D
R
C
I
R
T
T
Y
V
T
Q
R
-
P
V
Y
L
G
L
P
ANL
V
D
L
N
V
P
A
K
L
L
Q
T
-
P
I
D
M
S
---
L
K
---------
P
N
D
A
-
E
S
---
E
K
E
V
I
D
T
I
L
VLD
K
D
A
K
N
P
V
I
L
A
D
A
C
C
S
R
H
D
V
K
A
E
T
K
K
L
I
D
L
T
Q
F
P
A
F
-
V
T
P
M
G
K
G
S
I
D
E
Q
H
P
R
Y
G
G
V
Y
V
G
T
L
S
K
P
E
V
K
E
A
V
E
S
A
D
L
I
L
S
V
G
A
L
L
S
D
F
N
T
G
S
F
S
Y
S
Y
K
T
K
N
I
V
E
F
----
H
S
D
H
M
K
I
R
N
A
------
T
F
P
G
V
-
Q
M
K
F
V
L
Q
K
L
L
T
A
I
-----
A
D
A
A
K
G
Y
K
-
P
V
A
V
P
A
R
T
P
A
N
---
A
A
VP
A
S
T
P
L
K
Q
E
W
M
W
N
Q
L
G
N
F
L
Q
E
G
D
V
V
I
A
E
T
G
T
S
A
F
G
-
I
N
Q
T
T
F
P
N
N
T
Y
G
I
S
Q
V
L
W
G
S
I
G
F
T
T
G
A
T
L
G
A
A
F
A
AEEI
D
P
K
----
K
R
V
I
L
F
I
G
D
G
S
L
Q
L
T
V
Q
E
I
S
T
M
I
R
W
G
L
K
P
Y
L
F
V
L
N
N
D
G
Y
T
I
E
K
L
I
H
G
P
K
A
Q
Y
N
E
I
Q
G
W
D
H
L
S
L
L
P
T
F
G
-
A
-
K
D
-
Y
E
T
H
R
V
ATTG
E
W
D
K
L
T
Q
D
K
S
F
N
-------
D
N
S
K
I
R
M
I
E
V
M
L
P
V
F
D
A
P
Q
N
L
V
E
Q
A
K
L
T
A
A
T
N
-
29
PsiBlast_CBE
94.65
40%
-90
- C6 -
1PVD
3
PDC1_YEAST
B:
[5-553]
----
L
G
K
Y
L
F
E
R
L
K
Q
V
N
V
N
T
V
F
G
L
P
G
D
F
N
L
S
L
L
D
K
I
Y
E
V
E
G
M
R
W
A
G
N
A
N
E
L
N
A
A
Y
A
A
D
G
Y
A
R
I
K
G
M
S
C
I
I
T
T
F
G
V
G
E
L
S
A
L
N
G
I
A
G
S
Y
A
E
H
V
G
V
L
H
V
V
G
V
P
S
I
S
--------
H
H
T
L
G
N
G
D
F
T
V
F
H
R
M
S
A
N
I
S
E
T
T
A
M
I
T
-
D
I
A
T
-
A
P
A
E
I
D
R
C
I
R
T
T
Y
V
T
Q
R
-
P
V
Y
L
G
L
P
ANL
V
D
L
N
V
P
A
K
L
L
Q
T
-
P
I
D
M
S
---
L
K
---------
P
N
D
A
-
E
S
---
E
K
E
V
I
D
T
I
L
ALV
K
D
A
K
N
P
V
I
L
A
D
A
C
C
S
R
H
D
V
K
A
E
T
K
K
L
I
D
L
T
Q
F
P
A
F
-
V
T
P
M
G
K
G
S
I
S
E
Q
H
P
R
Y
G
G
V
Y
V
G
T
L
S
K
P
E
V
K
E
A
V
E
S
A
D
L
I
L
S
V
G
A
L
L
S
D
----------
K
T
K
N
I
V
E
F
----
H
S
D
H
M
K
I
R
N
A
------
T
F
P
G
V
-
Q
M
K
F
V
L
Q
K
L
L
T
N
I
-----
A
D
A
A
K
G
Y
K
-
P
V
A
V
P
A
R
T
P
A
N
---
A
A
VP
A
S
T
P
L
K
Q
E
W
M
W
N
Q
L
G
N
F
L
Q
E
G
D
V
V
I
A
E
T
G
T
S
A
F
G
-
I
N
Q
T
T
F
P
N
N
T
Y
G
I
S
Q
V
L
W
G
S
I
G
F
T
T
G
A
T
L
G
A
A
F
A
AEEI
D
P
K
----
K
R
V
I
L
F
I
G
D
G
S
L
Q
L
T
V
Q
E
I
S
T
M
I
R
W
G
L
K
P
Y
L
F
V
L
N
N
D
G
Y
T
I
E
K
L
I
H
G
P
K
A
Q
Y
N
E
I
Q
G
W
D
H
L
S
L
L
P
T
F
G
-
A
-
K
D
-
Y
E
T
H
R
V
ATTG
E
W
D
K
L
T
Q
D
K
S
F
N
-------
D
N
S
K
I
R
M
I
E
I
M
L
P
V
F
D
A
P
Q
N
L
V
K
Q
A
K
-------
5
PsiBlast_PDB
94.64
39%
-83
- C6 -
2VK8
4
PDC1_YEAST
A:
[6-560]
----
L
G
K
Y
L
F
E
R
L
K
Q
V
N
V
N
T
V
F
G
L
P
G
D
F
N
L
S
L
L
D
K
I
Y
E
V
E
G
M
R
W
A
G
N
A
N
E
L
N
A
A
Y
A
A
D
G
Y
A
R
I
K
G
M
S
C
I
I
T
T
F
G
V
G
E
L
S
A
L
N
G
I
A
G
S
Y
A
E
H
V
G
V
L
H
V
V
G
V
P
S
I
S
A
Q
A
K
Q
L
L
L
H
H
T
L
G
N
G
D
F
T
V
F
H
R
M
S
A
N
I
S
E
T
T
A
M
I
T
-
D
I
A
T
-
A
P
A
E
I
D
R
C
I
R
T
T
Y
V
T
Q
R
-
P
V
Y
L
G
L
P
A
N
L
V
D
L
N
V
P
A
K
L
L
Q
T
-
P
I
D
M
S
---
L
K
---------
P
N
D
A
-
E
S
---
E
K
E
V
I
D
T
I
L
V
L
D
K
D
A
K
N
P
V
I
L
A
D
A
C
C
S
R
H
D
V
K
A
E
T
K
K
L
I
D
L
T
Q
F
P
A
F
-
V
T
P
M
G
K
G
S
I
D
E
Q
H
P
R
Y
G
G
V
Y
V
G
T
L
S
K
P
E
V
K
E
A
V
E
S
A
D
L
I
L
S
V
G
A
L
L
S
D
F
N
T
G
S
F
S
Y
S
Y
K
T
K
N
I
V
E
F
----
H
S
D
H
M
K
I
R
N
A
------
T
F
P
G
V
-
Q
M
K
F
V
L
Q
K
L
L
T
T
I
-----
A
D
A
A
K
G
Y
K
-
P
V
A
V
P
A
R
T
P
A
N
---
A
A
VP
A
S
T
P
L
K
Q
E
W
M
W
N
Q
L
G
N
F
L
Q
E
G
D
V
V
I
A
E
T
G
T
S
A
F
G
-
I
N
Q
T
T
F
P
N
N
T
Y
G
I
S
Q
V
L
W
G
S
I
G
F
T
T
G
A
T
L
G
A
A
F
A
A
E
E
I
D
P
K
----
K
R
V
I
L
F
I
G
D
G
S
L
Q
L
T
V
Q
E
I
S
T
M
I
R
W
G
L
K
P
Y
L
F
V
L
N
N
D
G
Y
T
I
Q
K
L
I
H
G
P
K
A
Q
Y
N
E
I
Q
G
W
D
H
L
S
L
L
P
T
F
G
-
A
-
K
D
-
Y
E
T
H
R
V
AT
T
G
E
W
D
K
L
T
Q
D
---
K
---
S
F
N
D
N
S
K
I
-
R
M
I
E
V
M
L
P
V
F
D
A
P
Q
N
L
V
E
Q
A
K
L
T
A
A
T
N
-
25
PsiBlast_CBE
94.52
39%
-83
- C6 -
2W93
6
PDC1_YEAST
C:
[6-558]
----
L
G
K
Y
L
F
E
R
L
K
Q
V
N
V
N
T
V
F
G
L
P
G
D
F
N
L
S
L
L
D
K
I
Y
E
V
E
G
M
R
W
A
G
N
A
N
E
L
N
A
A
Y
A
A
D
G
Y
A
R
I
K
G
M
S
C
I
I
T
T
F
G
V
G
E
L
S
A
L
N
G
I
A
G
S
Y
A
E
H
V
G
V
L
H
V
V
G
V
P
S
I
S
S
Q
A
K
Q
L
L
L
H
H
T
L
G
N
G
D
F
T
V
F
H
R
M
S
A
N
I
S
E
T
T
A
M
I
T
-
D
I
A
T
-
A
P
A
E
I
D
R
C
I
R
T
T
Y
V
T
Q
R
-
P
V
Y
L
G
L
P
ANL
V
D
L
N
V
P
A
K
L
L
Q
T
-
P
I
D
M
S
---
L
K
---------
P
N
D
A
-
E
S
---
E
K
E
V
I
D
T
I
L
ALV
K
D
A
K
N
P
V
I
L
A
D
A
C
C
S
R
H
D
V
K
A
E
T
K
K
L
I
D
L
T
Q
F
P
A
F
-
V
T
P
M
G
K
G
S
I
D
E
Q
H
P
R
Y
G
G
V
Y
V
G
T
L
S
K
P
E
V
K
E
A
V
E
S
A
D
L
I
L
S
V
G
A
L
L
S
D
F
N
T
G
S
F
S
Y
S
Y
K
T
K
N
I
V
E
F
----
H
S
D
H
M
K
I
R
N
A
------
T
F
P
G
V
-
Q
M
K
F
V
L
Q
K
L
L
T
N
I
-----
A
D
A
A
K
G
Y
K
-
P
V
A
V
P
A
R
T
P
A
N
---
A
A
VP
A
S
T
P
L
K
Q
E
W
M
W
N
Q
L
G
N
F
L
Q
E
G
D
V
V
I
A
E
T
G
T
S
A
F
G
-
I
N
Q
T
T
F
P
N
N
T
Y
G
I
S
Q
V
L
W
G
S
I
G
F
T
T
G
A
T
L
G
A
A
F
A
AEEI
D
P
K
----
K
R
V
I
L
F
I
G
D
G
S
L
Q
L
T
V
Q
E
I
S
T
M
I
R
W
G
L
K
P
Y
L
F
V
L
N
N
D
G
Y
T
I
Q
K
L
I
H
G
P
K
A
Q
Y
N
E
I
Q
G
W
D
H
L
S
L
L
P
T
F
G
-
A
-
K
D
-
Y
E
T
H
R
V
ATTG
E
W
D
K
L
T
Q
D
---
K
---
S
F
N
D
N
S
K
I
-
R
M
I
E
V
M
L
P
V
F
D
A
P
Q
N
L
V
E
Q
A
K
L
T
A
A
---
6
PsiBlast_PDB
94.47
39%
-84
- C6 -
2VK1
6
PDC1_YEAST
A:
[6-560]
----
L
G
K
Y
L
F
E
R
L
K
Q
V
N
V
N
T
V
F
G
L
P
G
A
F
N
L
S
L
L
D
K
I
Y
E
V
E
G
M
R
W
A
G
N
A
N
E
L
N
A
A
Y
A
A
D
G
Y
A
R
I
K
G
M
S
C
I
I
T
T
F
G
V
G
E
L
S
A
L
N
G
I
A
G
S
Y
A
E
H
V
G
V
L
H
V
V
G
V
P
S
I
S
A
Q
A
K
Q
L
L
L
H
H
T
L
G
N
G
D
F
T
V
F
H
R
M
S
A
N
I
S
E
T
T
A
M
I
T
-
D
I
A
T
-
A
P
A
E
I
D
R
C
I
R
T
T
Y
V
T
Q
R
-
P
V
Y
L
G
L
P
A
N
L
V
D
L
N
V
P
A
K
L
L
Q
T
-
P
I
D
M
S
---
L
K
---------
P
N
D
A
-
E
S
---
E
K
E
V
I
D
T
I
L
V
L
D
K
D
A
K
N
P
V
I
L
A
D
A
C
C
S
R
H
D
V
K
A
E
T
K
K
L
I
D
L
T
Q
F
P
A
F
-
V
T
P
M
G
K
G
S
I
D
E
Q
H
P
R
Y
G
G
V
Y
V
G
T
L
S
K
P
E
V
K
E
A
V
E
S
A
D
L
I
L
S
V
G
A
L
L
S
D
F
N
T
G
S
F
S
Y
S
Y
K
T
K
N
I
V
E
F
----
H
S
D
H
M
K
I
R
N
A
------
T
F
P
G
V
-
Q
M
K
F
V
L
Q
K
L
L
T
A
I
-----
A
D
A
A
K
G
Y
K
-
P
V
A
V
P
A
R
T
P
A
N
---
A
A
VP
A
S
T
P
L
K
Q
E
W
M
W
N
Q
L
G
N
F
L
Q
E
G
D
V
V
I
A
E
T
G
T
S
A
F
G
-
I
N
Q
T
T
F
P
N
N
T
Y
G
I
S
Q
V
L
W
G
S
I
G
F
T
T
G
A
T
L
G
A
A
F
A
A
E
E
I
D
P
K
----
K
R
V
I
L
F
I
G
D
G
S
L
Q
L
T
V
Q
E
I
S
T
M
I
R
W
G
L
K
P
Y
L
F
V
L
N
N
D
G
Y
T
I
E
K
L
I
H
G
P
K
A
Q
Y
N
E
I
Q
G
W
D
H
L
S
L
L
P
T
F
G
-
A
-
K
D
-
Y
E
T
H
R
V
AT
T
G
E
W
D
K
L
T
Q
D
K
S
F
N
-------
D
N
S
K
I
R
M
I
E
V
M
L
P
V
F
D
A
P
Q
N
L
V
E
Q
A
K
L
T
A
A
T
N
-
33
PsiBlast_CBE
94.32
39%
-84
- C6 -
2VK1
6
PDC1_YEAST
D:
[6-560]
----
L
G
K
Y
L
F
E
R
L
K
Q
V
N
V
N
T
V
F
G
L
P
G
A
F
N
L
S
L
L
D
K
I
Y
E
V
E
G
M
R
W
A
G
N
A
N
E
L
N
A
A
Y
A
A
D
G
Y
A
R
I
K
G
M
S
C
I
I
T
T
F
G
V
G
E
L
S
A
L
N
G
I
A
G
S
Y
A
E
H
V
G
V
L
H
V
V
G
V
P
S
I
S
A
Q
A
K
Q
L
L
L
H
H
T
L
G
N
G
D
F
T
V
F
H
R
M
S
A
N
I
S
E
T
T
A
M
I
T
-
D
I
A
T
-
A
P
A
E
I
D
R
C
I
R
T
T
Y
V
T
Q
R
-
P
V
Y
L
G
L
P
ANL
V
D
L
N
V
P
A
K
L
L
Q
T
-
P
I
D
M
S
---
L
K
---------
P
N
D
A
-
E
S
---
E
K
E
V
I
D
T
I
L
VLD
K
D
A
K
N
P
V
I
L
A
D
A
C
C
S
R
H
D
V
K
A
E
T
K
K
L
I
D
L
T
Q
F
P
A
F
-
V
T
P
M
G
K
G
S
I
D
E
Q
H
P
R
Y
G
G
V
Y
V
G
T
L
S
K
P
E
V
K
E
A
V
E
S
A
D
L
I
L
S
V
G
A
L
L
S
D
F
N
T
G
S
F
S
Y
S
Y
K
T
K
N
I
V
E
F
----
H
S
D
H
M
K
I
R
N
A
------
T
F
P
G
V
-
Q
M
K
F
V
L
Q
K
L
L
T
A
I
-----
A
D
A
A
K
G
Y
K
-
P
V
A
V
P
A
R
T
P
A
N
---
A
A
VP
A
S
T
P
L
K
Q
E
W
M
W
N
Q
L
G
N
F
L
Q
E
G
D
V
V
I
A
E
T
G
T
S
A
F
G
-
I
N
Q
T
T
F
P
N
N
T
Y
G
I
S
Q
V
L
W
G
S
I
G
F
T
T
G
A
T
L
G
A
A
F
A
AEEI
D
P
K
----
K
R
V
I
L
F
I
G
D
G
S
L
Q
L
T
V
Q
E
I
S
T
M
I
R
W
G
L
K
P
Y
L
F
V
L
N
N
D
G
Y
T
I
E
K
L
I
H
G
P
K
A
Q
Y
N
E
I
Q
G
W
D
H
L
S
L
L
P
T
F
G
-
A
-
K
D
-
Y
E
T
H
R
V
ATTG
E
W
D
K
L
T
Q
D
K
S
F
N
-------
D
N
S
K
I
R
M
I
E
V
M
L
P
V
F
D
A
P
Q
N
L
V
E
Q
A
K
L
T
A
A
T
N
-
2
PsiBlast_PDB
94.12
39%
-89
- C6 -
1QPB
5
PDC1_YEAST
A:
[6-556]
----
L
G
K
Y
L
F
E
R
L
K
Q
V
N
V
N
T
V
F
G
L
P
G
D
F
N
L
S
L
L
D
K
I
Y
E
V
E
G
M
R
W
A
G
N
A
N
E
L
N
A
A
Y
A
A
D
G
Y
A
R
I
K
G
M
S
C
I
I
T
T
F
G
V
G
E
L
S
A
L
N
G
I
A
G
S
Y
A
E
H
V
G
V
L
H
V
V
G
V
P
S
I
S
A
Q
A
K
Q
L
L
L
H
H
T
L
G
N
G
D
F
T
V
F
H
R
M
S
A
N
I
S
E
T
T
A
M
I
T
-
D
I
A
T
-
A
P
A
E
I
D
R
C
I
R
T
T
Y
V
T
Q
R
-
P
V
Y
L
G
L
P
ANL
V
D
L
N
V
P
A
K
L
L
Q
T
-
P
I
D
M
S
---
L
K
---------
P
N
D
A
-
E
S
---
E
K
E
V
I
D
T
I
L
V
L
I
K
D
A
K
N
P
V
I
L
A
D
A
C
C
S
R
H
D
V
K
A
E
T
K
K
L
I
D
L
T
Q
F
P
A
F
-
V
T
P
M
G
K
G
S
I
D
E
Q
H
P
R
Y
G
G
V
Y
V
G
T
L
S
K
P
E
V
K
E
A
V
E
S
A
D
L
I
L
S
V
G
A
L
L
S
D
F
N
T
G
S
F
S
Y
S
Y
K
T
K
N
I
V
E
F
----
H
S
D
H
M
K
I
R
N
A
------
T
F
P
G
V
-
Q
M
K
F
V
L
Q
K
L
L
T
A
I
-----
A
D
A
A
K
G
Y
K
-
P
V
A
V
P
A
R
T
P
A
N
---
A
A
VP
A
S
T
P
L
K
Q
E
W
M
W
N
Q
L
G
N
F
L
Q
E
G
D
V
V
I
A
E
T
G
T
S
A
F
G
-
I
N
Q
T
T
F
P
N
N
T
Y
G
I
S
Q
V
L
W
G
S
I
G
F
T
T
G
A
T
L
G
A
A
F
A
A
E
E
I
D
P
K
----
K
R
V
I
L
F
I
G
D
G
S
L
Q
L
T
V
Q
E
I
S
T
M
I
R
W
G
L
K
P
Y
L
F
V
L
N
N
D
G
Y
T
I
E
K
L
I
H
G
P
K
A
Q
Y
N
E
I
Q
G
W
D
H
L
S
L
L
P
T
F
G
-
A
-
K
D
-
Y
E
T
H
R
V
A
T
T
G
E
W
D
K
L
T
Q
D
---
K
---
S
F
N
D
N
S
K
I
-
R
M
I
E
V
M
L
P
V
F
D
A
P
Q
N
L
V
E
Q
A
K
L
T
-----
4
PsiBlast_PDB
94.07
40%
-87
- C6 -
1PVD
3
PDC1_YEAST
A:
[5-553]
----
L
G
K
Y
L
F
E
R
L
K
Q
V
N
V
N
T
V
F
G
L
P
G
D
F
N
L
S
L
L
D
K
I
Y
E
V
E
G
M
R
W
A
G
N
A
N
E
L
N
A
A
Y
A
A
D
G
Y
A
R
I
K
G
M
S
C
I
I
T
T
F
G
V
G
E
L
S
A
L
N
G
I
A
G
S
Y
A
E
H
V
G
V
L
H
V
V
G
V
P
S
I
S
--------
H
H
T
L
G
N
G
D
F
T
V
F
H
R
M
S
A
N
I
S
E
T
T
A
M
I
T
-
D
I
A
T
-
A
P
A
E
I
D
R
C
I
R
T
T
Y
V
T
Q
R
-
P
V
Y
L
G
L
P
ANL
V
D
L
N
V
P
A
K
L
L
Q
T
-
P
I
D
M
S
---
L
K
---------
P
N
D
A
-
E
S
---
E
K
E
V
I
D
T
I
L
A
L
V
K
D
A
K
N
P
V
I
L
A
D
A
C
C
S
R
H
D
V
K
A
E
T
K
K
L
I
D
L
T
Q
F
P
A
F
-
V
T
P
M
G
K
G
S
I
S
E
Q
H
P
R
Y
G
G
V
Y
V
G
T
L
S
K
P
E
V
K
E
A
V
E
S
A
D
L
I
L
S
V
G
A
L
L
S
D
----------
K
T
K
N
I
V
E
F
----
H
S
D
H
M
K
I
R
N
A
------
T
F
P
G
V
-
Q
M
K
F
V
L
Q
K
L
L
T
N
I
-----
A
D
A
A
K
G
Y
K
-
P
V
A
V
P
A
R
T
P
A
N
---
A
A
VP
A
S
T
P
L
K
Q
E
W
M
W
N
Q
L
G
N
F
L
Q
E
G
D
V
V
I
A
E
T
G
T
S
A
F
G
-
I
N
Q
T
T
F
P
N
N
T
Y
G
I
S
Q
V
L
W
G
S
I
G
F
T
T
G
A
T
L
G
A
A
F
A
A
E
E
I
D
P
K
----
K
R
V
I
L
F
I
G
D
G
S
L
Q
L
T
V
Q
E
I
S
T
M
I
R
W
G
L
K
P
Y
L
F
V
L
N
N
D
G
Y
T
I
E
K
L
I
H
G
P
K
A
Q
Y
N
E
I
Q
G
W
D
H
L
S
L
L
P
T
F
G
-
A
-
K
D
-
Y
E
T
H
R
V
A
T
T
G
E
W
D
K
L
T
Q
D
K
S
F
N
-------
D
N
S
K
I
R
M
I
E
I
M
L
P
V
F
D
A
P
Q
N
L
V
K
Q
A
K
-------
27
PsiBlast_CBE
94.04
39%
-89
- C6 -
1QPB
4
PDC1_YEAST
B:
[6-556]
----
L
G
K
Y
L
F
E
R
L
K
Q
V
N
V
N
T
V
F
G
L
P
G
D
F
N
L
S
L
L
D
K
I
Y
E
V
E
G
M
R
W
A
G
N
A
N
E
L
N
A
A
Y
A
A
D
G
Y
A
R
I
K
G
M
S
C
I
I
T
T
F
G
V
G
E
L
S
A
L
N
G
I
A
G
S
Y
A
E
H
V
G
V
L
H
V
V
G
V
P
S
I
S
A
Q
A
K
Q
L
L
L
H
H
T
L
G
N
G
D
F
T
V
F
H
R
M
S
A
N
I
S
E
T
T
A
M
I
T
-
D
I
A
T
-
A
P
A
E
I
D
R
C
I
R
T
T
Y
V
T
Q
R
-
P
V
Y
L
G
L
P
ANL
V
D
L
N
V
P
A
K
L
L
Q
T
-
P
I
D
M
S
---
L
K
---------
P
N
D
A
-
E
S
---
E
K
E
V
I
D
T
I
L
VLI
K
D
A
K
N
P
V
I
L
A
D
A
C
C
S
R
H
D
V
K
A
E
T
K
K
L
I
D
L
T
Q
F
P
A
F
-
V
T
P
M
G
K
G
S
I
D
E
Q
H
P
R
Y
G
G
V
Y
V
G
T
L
S
K
P
E
V
K
E
A
V
E
S
A
D
L
I
L
S
V
G
A
L
L
S
D
F
N
T
G
S
F
S
Y
S
Y
K
T
K
N
I
V
E
F
----
H
S
D
H
M
K
I
R
N
A
------
T
F
P
G
V
-
Q
M
K
F
V
L
Q
K
L
L
T
A
I
-----
A
D
A
A
K
G
Y
K
-
P
V
A
V
P
A
R
T
P
A
N
---
A
A
VP
A
S
T
P
L
K
Q
E
W
M
W
N
Q
L
G
N
F
L
Q
E
G
D
V
V
I
A
E
T
G
T
S
A
F
G
-
I
N
Q
T
T
F
P
N
N
T
Y
G
I
S
Q
V
L
W
G
S
I
G
F
T
T
G
A
T
L
G
A
A
F
A
AEEI
D
P
K
----
K
R
V
I
L
F
I
G
D
G
S
L
Q
L
T
V
Q
E
I
S
T
M
I
R
W
G
L
K
P
Y
L
F
V
L
N
N
D
G
Y
T
I
E
K
L
I
H
G
P
K
A
Q
Y
N
E
I
Q
G
W
D
H
L
S
L
L
P
T
F
G
-
A
-
K
D
-
Y
E
T
H
R
V
ATTG
E
W
D
K
L
T
Q
D
---
K
---
S
F
N
D
N
S
K
I
-
R
M
I
E
V
M
L
P
V
F
D
A
P
Q
N
L
V
E
Q
A
K
L
T
-----
28
PsiBlast_CBE
93.10
40%
-87
- C6 -
1PYD
3
PDC1_YEAST
B:
[6-554]
----
L
G
K
Y
L
F
E
R
L
K
Q
V
N
V
N
T
V
F
G
L
P
G
D
F
N
L
S
L
L
D
K
I
Y
E
V
E
G
M
R
W
A
G
N
A
N
E
L
N
A
A
Y
A
A
D
G
Y
A
R
I
K
G
M
S
C
I
I
T
T
F
G
V
G
E
L
S
A
L
N
G
I
A
G
S
Y
A
E
H
V
G
V
L
H
V
V
G
V
P
S
I
S
--------
H
H
T
L
G
N
G
D
F
T
V
F
H
R
M
S
A
N
I
S
E
T
T
A
M
I
T
-
D
I
A
T
-
A
P
A
E
I
D
R
C
I
R
T
T
Y
V
T
Q
R
-
P
V
Y
L
G
L
P
ANL
V
D
L
N
V
P
A
K
L
L
Q
T
-
P
I
D
M
S
---
L
K
---------
P
N
D
A
-
E
S
---
E
K
E
V
I
D
T
I
L
ALV
K
D
A
K
N
P
V
I
L
A
D
A
C
C
S
R
H
D
V
K
A
E
T
K
K
L
I
D
L
T
Q
F
P
A
F
-
V
T
P
M
G
K
G
S
I
S
E
Q
H
P
R
Y
G
G
V
Y
V
G
T
L
S
K
P
E
V
K
E
A
V
E
S
A
D
L
I
L
S
V
G
A
L
L
S
D
----------
K
T
K
N
I
V
E
F
----
H
S
D
H
M
K
I
R
N
A
------
T
F
P
G
V
-
Q
M
K
F
V
L
Q
K
L
L
T
N
I
-----
A
D
A
A
K
G
Y
K
-
P
V
A
V
P
A
R
T
P
A
N
---
A
A
VP
A
S
T
P
L
K
Q
E
W
M
W
N
Q
L
G
N
F
L
Q
E
G
D
V
V
I
A
E
T
G
T
S
A
F
G
-
I
N
Q
T
T
F
P
N
N
T
Y
G
I
S
Q
V
L
W
G
S
I
G
F
T
T
G
A
T
L
G
A
A
F
A
AEEI
D
P
K
----
K
R
V
I
L
F
I
G
D
G
S
L
Q
L
T
V
Q
E
I
S
T
M
I
R
W
G
L
K
P
Y
L
F
V
L
N
N
D
G
Y
T
I
E
K
L
I
H
G
P
K
A
Q
Y
N
E
I
Q
G
W
D
H
L
S
L
L
P
T
F
G
-
A
-
K
D
-
Y
E
T
H
R
V
ATTG
E
W
D
K
L
T
Q
D
K
S
F
N
-------
D
N
S
K
I
R
M
I
E
I
M
L
P
V
F
D
A
P
Q
N
L
V
K
Q
A
K
-------
3
PsiBlast_PDB
92.86
40%
-87
- C6 -
1PYD
3
PDC1_YEAST
A:
[6-554]
----
L
G
K
Y
L
F
E
R
L
K
Q
V
N
V
N
T
V
F
G
L
P
G
D
F
N
L
S
L
L
D
K
I
Y
E
V
E
G
M
R
W
A
G
N
A
N
E
L
N
A
A
Y
A
A
D
G
Y
A
R
I
K
G
M
S
C
I
I
T
T
F
G
V
G
E
L
S
A
L
N
G
I
A
G
S
Y
A
E
H
V
G
V
L
H
V
V
G
V
P
S
I
S
--------
H
H
T
L
G
N
G
D
F
T
V
F
H
R
M
S
A
N
I
S
E
T
T
A
M
I
T
-
D
I
A
T
-
A
P
A
E
I
D
R
C
I
R
T
T
Y
V
T
Q
R
-
P
V
Y
L
G
L
P
ANL
V
D
L
N
V
P
A
K
L
L
Q
T
-
P
I
D
M
S
---
L
K
---------
P
N
D
A
-
E
S
---
E
K
E
V
I
D
T
I
L
A
L
V
K
D
A
K
N
P
V
I
L
A
D
A
C
C
S
R
H
D
V
K
A
E
T
K
K
L
I
D
L
T
Q
F
P
A
F
-
V
T
P
M
G
K
G
S
I
S
E
Q
H
P
R
Y
G
G
V
Y
V
G
T
L
S
K
P
E
V
K
E
A
V
E
S
A
D
L
I
L
S
V
G
A
L
L
S
D
----------
K
T
K
N
I
V
E
F
----
H
S
D
H
M
K
I
R
N
A
------
T
F
P
G
V
-
Q
M
K
F
V
L
Q
K
L
L
T
N
I
-----
A
D
A
A
K
G
Y
K
-
P
V
A
V
P
A
R
T
P
A
N
---
A
A
VP
A
S
T
P
L
K
Q
E
W
M
W
N
Q
L
G
N
F
L
Q
E
G
D
V
V
I
A
E
T
G
T
S
A
F
G
-
I
N
Q
T
T
F
P
N
N
T
Y
G
I
S
Q
V
L
W
G
S
I
G
F
T
T
G
A
T
L
G
A
A
F
A
A
E
E
I
D
P
K
----
K
R
V
I
L
F
I
G
D
G
S
L
Q
L
T
V
Q
E
I
S
T
M
I
R
W
G
L
K
P
Y
L
F
V
L
N
N
D
G
Y
T
I
E
K
L
I
H
G
P
K
A
Q
Y
N
E
I
Q
G
W
D
H
L
S
L
L
P
T
F
G
-
A
-
K
D
-
Y
E
T
H
R
V
AT
T
G
E
W
D
K
L
T
Q
D
K
S
F
N
-------
D
N
S
K
I
R
M
I
E
I
M
L
P
V
F
D
A
P
Q
N
L
V
K
Q
A
K
-------
67
Fugue
92.11
38%
-88
- C6 -
1PVD
3
PDC1_YEAST
A:
[1-545]
S
E
I
T
L
G
K
Y
L
F
E
R
L
K
Q
V
N
V
N
T
V
F
G
L
P
G
D
F
N
L
S
L
L
D
K
I
Y
E
V
E
G
M
R
W
A
G
N
A
N
E
L
N
A
A
Y
A
A
D
G
Y
A
R
I
K
G
M
S
C
I
I
T
T
F
G
V
G
E
L
S
A
L
N
G
I
A
G
S
Y
A
E
H
V
G
V
L
H
V
V
G
V
P
S
I
S
--------
H
H
T
L
G
N
G
D
F
T
V
F
H
R
M
S
A
N
I
S
E
T
T
A
M
I
T
D
I
-
A
T
-
A
P
A
E
I
D
R
C
I
R
T
T
Y
V
-
T
Q
R
P
V
Y
L
G
L
P
---
A
N
L
V
D
L
N
V
P
-----
A
K
L
L
--
Q
T
P
IDM
S
L
K
P
N
D
A
E
S
E
-
K
E
---
V
I
D
T
I
L
A
L
V
---
K
D
A
K
N
P
V
I
L
A
D
A
C
C
S
R
H
D
V
K
A
E
T
K
K
L
I
D
L
T
Q
F
P
A
F
V
T
-
P
M
G
K
G
S
I
S
E
Q
H
P
R
Y
G
G
V
Y
V
G
T
L
S
K
P
E
V
K
E
A
V
E
S
A
D
L
I
L
S
V
G
A
L
L
S
D
K
-----------
T
K
N
I
V
E
F
H
SD---
H
M
K
I
R
N
A
------
T
F
P
G
V
-
Q
M
K
F
V
L
-
Q
K
L
L
T
N
I
A
D
A
A
--
K
G
Y
K
P
V
-
A
V
P
A
R
T
P
A
N
A
A
---
V
P
--
A
S
T
P
L
K
Q
E
W
M
W
N
Q
L
G
N
F
L
Q
E
G
D
V
V
I
A
E
T
G
T
S
A
F
G
I
N
Q
T
T
F
P
N
N
T
Y
G
-
I
S
Q
V
L
W
G
S
I
G
F
T
T
G
A
T
L
G
A
A
F
A
----
A
E
E
I
DPK
K
R
V
I
L
F
I
G
D
G
S
L
Q
L
T
V
Q
E
I
S
T
M
I
R
W
G
L
K
P
Y
L
F
V
L
N
N
D
G
Y
T
I
E
K
L
I
H
G
P
K
A
Q
Y
N
E
I
Q
G
W
D
H
L
S
L
L
P
T
F
G
--A
K
D
-
Y
E
T
H
R
V
----
A
T
T
G
E
W
D
K
-
L
T
Q
DKS
F
N
D
N
-
S
-
K
I
R
M
I
E
I
M
L
P
V
F
D
A
P
---------------