@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0185: (2016-03-13 )
MMENSTTEARNEATMHLDEMTVEEALITMNKEDQQVPLAVRKAIPQLTKVIKKTIAQYKKGGRLIYIGAGTSGRLGVLDAAECVPTFNTDPHEIIGIIAGGQHAMTMAVEGAEDHKKLAEEDLKNIDLTSKDVVIGIAASGKTPYVIGGLTFANTIGATTVSISCNEHAVISEIAQYPVEVKVGPEVLTGSTRLKSGTAQKLILNMISTITMVGVGKVYDNLMIDVKATNQKLIDRSVRIIQEICAITYDEAMALYQVSEHDVKVATVMGMCGISKEEATRRLLNNGDIVKRAIRDRQP
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120-....--...130.......140-....--..-----------.150.......160.......--170-.......-.180......---.190-.-------------.......200.......210.......220.......230.......240..-------.....250......--------------------------.260.......270.......280.......290.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MMENSTTEARN
E
A
T
M
H
L
D
E
M
T
V
E
E
A
L
I
TMNKEDQQV
P
L
A
V
R
K
A
I
P
Q
L
T
K
V
I
K
K
T
I
A
Q
Y
KKG
G
R
L
I
Y
I
GAGTSGRLG
V
L
D
A
A
E
CVPTFNT
D
P
H
E
I
I
G
I
IAGGQ
H
A
M
T
M
A
VEG
A
E
D
H
K
K
L
A
E
E
D
-
L
K
NI--DLTSK
D
V
V
I
G
I
AASGK-T
P
Y
V
--
I
G-----------GL
T
F
ANTIG
A
T
T
V
S
I
SCN
E
H
A
--
V
I
--
S
E
I
AQY
P
-
V
E
V
KVGP
E
V
L---TGS--T-------------RLKSG
T
A
Q
K
L
I
L
N
M
I
S
T
I
T
M
V
G
V
G
K
V
YD
N
L
M
I
D
V
KAT
N
Q
K
L
I
D
R
S
V
R
I
I
Q
E
I
-------
C
A
I
T
Y
D
E
A
M
A
L
YQV--------------------------SEH
D
V
K
V
A
T
VMGMCGI
S
K
E
E
A
T
R
R
L
LNN
G
D
I
V
K
R
A
I
RDRQP
21
PsiBlast_CBE
99.24
50%
-98
- C1 -
4S12
5
?
C:
[11-298]
------
S
E
S
R
N
P
D
T
M
D
L
D
T
L
S
T
L
E
M
L
T
R
I
N
D
E
D
R
K
V
P
E
A
I
R
L
V
I
P
N
I
A
Q
A
V
D
L
A
A
K
A
L
R
D
G
G
R
L
I
Y
L
G
A
G
T
S
G
R
L
G
V
L
D
A
S
E
C
P
P
T
F
G
V
P
H
G
R
V
I
G
L
I
A
G
G
P
G
A
L
L
K
A
V
E
G
A
E
D
D
V
S
L
G
E
R
D
-
L
R
D
L
--
Q
L
T
A
T
D
M
V
V
G
L
A
A
S
G
R
-
T
P
Y
V
--
I
G
-----------
A
L
R
F
A
R
Q
L
G
C
P
T
A
A
I
S
C
N
P
D
S
--
P
I
--
A
Q
E
A
L
V
A
-
I
S
P
V
V
G
P
E
A
L
---
T
G
S
--
T
-------------
R
M
K
S
G
T
A
Q
K
L
V
L
N
M
L
S
T
G
A
M
V
K
L
G
K
V
Y
Q
N
L
M
V
D
V
K
A
T
N
V
K
L
V
D
R
A
C
R
I
V
V
E
A
-------
T
G
A
S
R
V
E
A
E
N
A
L
S
Q
--------------------------
T
E
F
E
V
K
P
A
I
L
M
I
L
K
G
V
S
V
E
Q
A
R
L
N
L
Q
Q
H
N
G
Y
L
R
A
A
L
-----
22
PsiBlast_CBE
97.56
50%
-97
- C1 -
4S12
3
?
B:
[11-298]
------
S
E
S
R
N
P
D
T
M
D
L
D
T
L
S
T
L
E
M
L
T
R
I
N
D
E
D
R
K
V
P
E
A
I
R
L
V
I
P
N
I
A
Q
A
V
D
L
A
A
K
A
L
R
D
G
G
R
L
I
Y
L
G
A
G
T
S
G
R
L
G
V
L
D
A
S
E
C
P
P
T
F
G
V
P
H
G
R
V
I
G
L
I
A
G
G
P
-----
A
V
E
G
A
E
D
D
V
S
L
G
E
R
D
-
L
R
D
L
--
Q
L
T
A
T
D
M
V
V
G
L
A
A
S
G
R
-
T
P
Y
V
--
I
G
-----------
A
L
R
F
A
R
Q
L
G
C
P
T
A
A
I
S
C
N
P
D
S
--
P
I
--
A
Q
E
A
L
V
A
-
I
S
P
V
V
G
P
E
A
L
---
T
G
S
--
T
-------------
R
M
K
S
G
T
A
Q
K
L
V
L
N
M
L
S
T
G
A
M
V
K
L
G
K
V
Y
Q
N
L
M
V
D
V
K
A
T
N
V
K
L
V
D
R
A
C
R
I
V
V
E
A
-------
T
G
A
S
R
V
E
A
E
N
A
L
S
Q
--------------------------
T
E
F
E
V
K
P
A
I
L
M
I
L
K
G
V
S
V
E
Q
A
R
L
N
L
Q
Q
H
N
G
Y
L
R
A
A
L
-----
1
PsiBlast_PDB
96.08
50%
-89
- C1 -
4S12
4
?
A:
[11-298]
------
S
E
S
R
N
P
D
T
M
D
L
D
T
L
S
T
L
E
M
L
T
R
I
N
D
E
D
R
K
V
P
E
A
I
R
L
V
I
P
N
I
A
Q
A
V
D
L
A
A
K
A
L
R
D
G
G
R
L
I
Y
L
G
A
G
T
S
G
R
L
G
V
L
D
A
S
E
C
P
P
T
F
G
V
P
H
G
R
V
I
G
L
I
A
G
G
P
G
A
L
L
K
A
V
E
G
A
E
D
D
V
S
L
G
E
R
D
-
L
R
D
L
--
Q
L
T
A
T
D
M
V
V
G
L
A
A
S
G
R
-
T
P
Y
V
--
I
G
-----------
A
L
R
F
A
R
Q
L
G
C
P
T
A
A
I
S
C
N
P
D
S
--
P
I
--
A
Q
E
A
L
V
A
-
I
S
P
V
V
G
P
E
A
L
---
T
G
S
--
T
-------------
R
M
K
S
G
T
A
Q
K
L
V
L
N
M
L
S
T
G
A
M
V
K
L
G
K
V
Y
Q
N
L
M
V
D
V
K
A
T
N
V
K
L
V
D
R
A
C
R
I
V
V
E
A
-------
T
G
A
S
R
V
E
A
E
N
A
L
S
Q
--------------------------
T
E
F
E
V
K
P
A
I
L
M
I
L
K
G
V
S
V
E
Q
A
R
L
N
L
Q
Q
H
N
G
Y
L
R
A
A
L
-----
25
PsiBlast_CBE
88.83
48%
-89
- C1 -
4LZJ
2
MURQ_HAEIN
B:
[14-286]
------
T
E
Q
R
N
P
N
S
V
D
I
D
R
Q
S
T
L
E
I
V
R
L
M
N
E
E
D
K
L
V
P
L
A
I
E
S
C
L
P
Q
I
S
L
A
V
E
Q
I
V
Q
A
F
Q
Q
G
G
R
L
I
Y
I
G
A
G
T
S
G
R
L
G
V
L
D
A
S
E
C
P
P
T
F
G
V
S
T
E
M
V
K
G
I
I
A
G
G
E
C
A
I
R
H
P
V
E
G
A
E
D
N
T
K
A
V
L
N
D
-
L
Q
S
I
--
H
F
S
K
N
D
V
L
V
G
I
A
A
S
G
R
-
T
P
Y
V
--
I
A
-----------
G
L
Q
Y
A
K
S
L
G
A
L
T
I
S
I
A
S
N
P
K
S
--
E
M
--
A
E
I
A
D
I
A
-
I
E
T
I
V
G
P
E
I
L
---
T
G
S
--
S
-------------
R
L
K
S
G
T
A
Q
K
M
V
L
N
M
L
T
T
A
S
M
I
L
L
G
K
C
Y
E
N
L
M
V
D
V
Q
A
S
N
E
K
L
K
A
R
A
V
R
I
V
M
Q
A
TD-----
C
N
K
T
L
A
E
Q
T
L
L
E
----------------------------
A
D
Q
N
A
K
L
A
I
M
M
I
L
S
T
L
S
K
S
E
A
--------------------
3
PsiBlast_PDB
88.74
48%
-91
- C1 -
4M0D
-
MURQ_HAEIN
A:
[14-286]
------
T
E
Q
R
N
P
N
S
V
D
I
D
R
Q
S
T
L
E
I
V
R
L
M
N
E
E
D
K
L
V
P
L
A
I
E
S
C
L
P
Q
I
S
L
A
V
E
Q
I
V
Q
A
F
Q
Q
G
G
R
L
I
Y
I
G
A
G
T
S
G
R
L
G
V
L
D
A
S
E
C
P
P
T
F
G
V
S
T
E
M
V
K
G
I
I
A
G
G
E
C
A
I
R
H
P
V
E
G
A
E
D
N
T
K
A
V
L
N
D
-
L
Q
S
I
--
H
F
S
K
N
D
V
L
V
G
I
A
A
S
G
R
-
T
P
Y
V
--
I
A
-----------
G
L
Q
Y
A
K
S
L
G
A
L
T
I
S
I
A
S
N
P
K
S
--
E
M
--
A
E
I
A
D
I
A
-
I
E
T
I
V
G
P
E
I
L
---
T
G
S
--
S
-------------
R
L
K
S
G
T
A
Q
K
M
V
L
N
M
L
T
T
A
S
M
I
L
L
G
K
C
Y
E
N
L
M
V
D
V
Q
A
S
N
E
K
L
K
A
R
A
V
R
I
V
M
Q
A
T
D-----
C
N
K
T
L
A
E
Q
T
L
L
E
----------------------------
A
D
Q
N
A
K
L
A
I
M
M
I
L
S
T
L
S
K
S
E
A
--------------------
2
PsiBlast_PDB
88.47
48%
-89
- C1 -
4LZJ
2
MURQ_HAEIN
A:
[14-286]
------
T
E
Q
R
N
P
N
S
V
D
I
D
R
Q
S
T
L
E
I
V
R
L
M
N
E
E
D
K
L
V
P
L
A
I
E
S
C
L
P
Q
I
S
L
A
V
E
Q
I
V
Q
A
F
Q
Q
G
G
R
L
I
Y
I
G
A
G
T
S
G
R
L
G
V
L
D
A
S
E
C
P
P
T
F
G
V
S
T
E
M
V
K
G
I
I
A
G
G
E
C
A
I
R
H
P
V
E
G
A
E
D
N
T
K
A
V
L
N
D
-
L
Q
S
I
--
H
F
S
K
N
D
V
L
V
G
I
A
A
S
G
R
-
T
P
Y
V
--
I
A
-----------
G
L
Q
Y
A
K
S
L
G
A
L
T
I
S
I
A
S
N
P
K
S
--
E
M
--
A
E
I
A
D
I
A
-
I
E
T
I
V
G
P
E
I
L
---
T
G
S
--
S
-------------
R
L
K
S
G
T
A
Q
K
M
V
L
N
M
L
T
T
A
S
M
I
L
L
G
K
C
Y
E
N
L
M
V
D
V
Q
A
S
N
E
K
L
K
A
R
A
V
R
I
V
M
Q
A
T
D-----
C
N
K
T
L
A
E
Q
T
L
L
E
----------------------------
A
D
Q
N
A
K
L
A
I
M
M
I
L
S
T
L
S
K
S
E
A
--------------------
23
PsiBlast_CBE
87.38
48%
-90
- C1 -
4LZJ
2
MURQ_HAEIN
D:
[14-286]
------
T
E
Q
R
N
P
N
S
V
D
I
D
R
Q
S
T
L
E
I
V
R
L
M
N
E
E
D
K
L
V
P
L
A
I
E
S
C
L
P
Q
I
S
L
A
V
E
Q
I
V
Q
A
F
Q
Q
G
G
R
L
I
Y
I
G
A
G
T
S
G
R
L
G
V
L
D
A
S
E
C
P
P
T
F
G
V
S
T
E
M
V
K
G
I
I
A
G
G
E
C
A
I
R
H
P
V
E
G
A
E
D
N
T
K
A
V
L
N
D
-
L
Q
S
I
--
H
F
S
K
N
D
V
L
V
G
I
A
A
S
G
R
-
T
P
Y
V
--
I
A
-----------
G
L
Q
Y
A
K
S
L
G
A
L
T
I
S
I
A
S
N
P
K
S
--
E
M
--
A
E
I
A
D
I
A
-
I
E
T
I
V
G
P
E
I
L
---
T
G
S
--
S
-------------
R
L
K
S
G
T
A
Q
K
M
V
L
N
M
L
T
T
A
S
M
I
L
L
G
K
C
Y
E
N
L
M
V
D
V
Q
A
S
N
E
K
L
K
A
R
A
V
R
I
V
M
Q
A
TD-----
C
N
K
T
L
A
E
Q
T
L
L
E
----------------------------
A
D
Q
N
A
K
L
A
I
M
M
I
L
S
T
L
S
K
S
E
A
--------------------
24
PsiBlast_CBE
87.34
48%
-88
- C1 -
4LZJ
2
MURQ_HAEIN
C:
[14-286]
------
T
E
Q
R
N
P
N
S
V
D
I
D
R
Q
S
T
L
E
I
V
R
L
M
N
E
E
D
K
L
V
P
L
A
I
E
S
C
L
P
Q
I
S
L
A
V
E
Q
I
V
Q
A
F
Q
Q
G
G
R
L
I
Y
I
G
A
G
T
S
G
R
L
G
V
L
D
A
S
E
C
P
P
T
F
G
V
S
T
E
M
V
K
G
I
I
A
G
G
E
C
A
I
R
H
P
V
E
G
A
E
D
N
T
K
A
V
L
N
D
-
L
Q
S
I
--
H
F
S
K
N
D
V
L
V
G
I
A
A
S
G
R
-
T
P
Y
V
--
I
A
-----------
G
L
Q
Y
A
K
S
L
G
A
L
T
I
S
I
A
S
N
P
K
S
--
E
M
--
A
E
I
A
D
I
A
-
I
E
T
I
V
G
P
E
I
L
---
T
G
S
--
S
-------------
R
L
K
S
G
T
A
Q
K
M
V
L
N
M
L
T
T
A
S
M
I
L
L
G
K
C
Y
E
N
L
M
V
D
V
Q
A
S
N
E
K
L
K
A
R
A
V
R
I
V
M
Q
A
TD-----
C
N
K
T
L
A
E
Q
T
L
L
E
----------------------------
A
D
Q
N
A
K
L
A
I
M
M
I
L
S
T
L
S
K
S
E
A
--------------------
27
HHSearch
61.21
22%
-77
- C1 -
3W0L
1
GCKR_XENLA
B:
[298-604]
--------------------------------
Y
E
R
A
H
K
V
T
Y
S
Q
S
K
K
I
A
A
L
M
K
Q
T
A
T
S
L
Q
K
K
G
H
L
Y
I
L
G
W
G
T
L
G
L
V
G
I
M
D
A
V
E
C
V
P
T
Y
Q
A
D
W
R
D
V
R
G
F
I
T
G
G
Y
H
S
I
E
N
K
----
E
G
D
L
S
S
L
G
P
Q
----
F
--
S
I
S
H
E
D
F
V
K
N
V
L
P
S
V
S
E
T
D
T
V
L
L
I
F
T
LDDD
L
N
Q
I
E
K
L
V
A
L
V
K
E
K
T
S
-
N
I
Q
V
I
C
H
A
T
A
G
Q
Y
L
P
N
S
L
K
K
T
I
P
S
I
I
G
L
T
W
P
I
L
F
LEY
E
G
A
F
I
Q
-------------
K
F
Q
R
E
L
S
T
K
W
I
L
D
T
V
T
S
G
A
Y
T
L
R
G
K
I
F
R
N
F
M
V
D
F
K
I
N
N
S
K
L
F
H
R
A
T
S
V
L
Q
R
L
-------
T
G
Q
S
Q
Q
R
C
T
E
V
L
L
Q
S
I
Y
GEQTLS
E
Q
I
R
N
TT
I
A
G
H
V
E
A
A
A
S
Q
D
K
V
L
P
V
A
I
V
S
L
L
R
S
C
T
I
Q
D
S
R
S
R
I
N
S
S
-
L
S
I
R
S
A
I
E
S
S
M
-
20
PsiBlast_PDB
58.92
20%
-78
- C1 -
4PX3
8
GCKR_HUMAN
A:
[323-579]
--------------------------------------------
P
K
I
A
T
L
M
K
S
V
S
T
S
L
E
K
K
G
H
V
Y
L
V
G
W
Q
T
L
G
I
I
A
I
M
D
G
V
E
C
I
H
T
F
G
A
D
F
R
D
V
R
G
F
L
I
----------------
F
T
F
S
Q
E
D
F
L
T
S
I
LP
S
L
T
E
I
D
T
V
V
F
I
F
T
L
D
D
-
N
L
T
E
--
V
Q
-------------
T
I
V
E
Q
V
K
E
K
T
N
H
I
Q
A
L
A
H
S
--
T
V
--
G
Q
T
L
P
I
P
-
L
K
-
K
L
F
P
S
I
I
---
S
I
T
--
W
P
LLFFEYEGN
F
I
Q
K
F
Q
R
E
L
S
T
K
W
V
L
N
T
V
S
T
G
A
H
V
L
L
G
K
I
L
Q
N
H
M
L
D
L
R
I
S
N
S
K
L
F
W
R
A
L
A
M
L
Q
R
F
SGQS
K
A
R
C
I
E
S
L
L
R
A
I
H
F
P
Q
P
--------------------------
L
S
D
D
I
R
A
A
P
I
S
C
H
V
Q
V
A
H
E
K
---------------------
17
PsiBlast_PDB
58.77
20%
-76
- C1 -
4OHK
7
GCKR_HUMAN
A:
[323-579]
--------------------------------------------
P
K
I
A
T
L
M
K
S
V
S
T
S
L
E
K
K
G
H
V
Y
L
V
G
W
Q
T
L
G
I
I
A
I
M
D
G
V
E
C
I
H
T
F
G
A
D
F
R
D
V
R
G
F
L
I
----------------
F
T
F
S
Q
E
D
F
L
T
S
I
LP
S
L
T
E
I
D
T
V
V
F
I
F
T
L
D
D
-
N
L
T
E
--
V
Q
-------------
T
I
V
E
Q
V
K
E
K
T
N
H
I
Q
A
L
A
H
S
--
T
V
--
G
Q
T
L
P
I
P
-
L
K
-
K
L
F
P
S
I
I
---
S
I
T
--
W
P
LLFFEYEGN
F
I
Q
K
F
Q
R
E
L
S
T
K
W
V
L
N
T
V
S
T
G
A
H
V
L
L
G
K
I
L
Q
N
H
M
L
D
L
R
I
S
N
S
K
L
F
W
R
A
L
A
M
L
Q
R
F
S
GQS
K
A
R
C
I
E
S
L
L
R
A
I
H
F
P
Q
P
--------------------------
L
S
D
D
I
R
A
A
P
I
S
C
H
V
Q
V
A
H
E
K
---------------------
10
PsiBlast_PDB
58.59
20%
-76
- C1 -
4OLH
9
GCKR_HUMAN
A:
[323-579]
--------------------------------------------
P
K
I
A
T
L
M
K
S
V
S
T
S
L
E
K
K
G
H
V
Y
L
V
G
W
Q
T
L
G
I
I
A
I
M
D
G
V
E
C
I
H
T
F
G
A
D
F
R
D
V
R
G
F
L
I
----------------
F
T
F
S
Q
E
D
F
L
T
S
I
LP
S
L
T
E
I
D
T
V
V
F
I
F
T
L
D
D
-
N
L
T
E
--
V
Q
-------------
T
I
V
E
Q
V
K
E
K
T
N
H
I
Q
A
L
A
H
S
--
T
V
--
G
Q
T
L
P
I
P
-
L
K
-
K
L
F
P
S
I
I
---
S
I
T
--
W
P
L
LFFEYEGN
F
I
Q
K
F
Q
R
E
L
S
T
K
W
V
L
N
T
V
S
T
G
A
H
V
L
L
G
K
I
L
Q
N
H
M
L
D
L
R
I
S
N
S
K
L
F
W
R
A
L
A
M
L
Q
R
F
S
GQS
K
A
R
C
I
E
S
L
L
R
A
I
H
F
P
Q
P
--------------------------
L
S
D
D
I
R
A
A
P
I
S
C
H
V
Q
V
A
H
E
K
---------------------
13
PsiBlast_PDB
58.38
20%
-77
- C1 -
4OHP
7
GCKR_HUMAN
A:
[323-579]
--------------------------------------------
P
K
I
A
T
L
M
K
S
V
S
T
S
L
E
K
K
G
H
V
Y
L
V
G
W
Q
T
L
G
I
I
A
I
M
D
G
V
E
C
I
H
T
F
G
A
D
F
R
D
V
R
G
F
L
I
----------------
F
T
F
S
Q
E
D
F
L
T
S
I
LP
S
L
T
E
I
D
T
V
V
F
I
F
T
L
D
D
-
N
L
T
E
--
V
Q
-------------
T
I
V
E
Q
V
K
E
K
T
N
H
I
Q
A
L
A
H
S
--
T
V
--
G
Q
T
L
P
I
P
-
L
K
-
K
L
F
P
S
I
I
---
S
I
T
--
W
P
L
L
F
F
EYEGN
F
I
Q
K
F
Q
R
E
L
S
T
K
W
V
L
N
T
V
S
T
G
A
H
V
L
L
G
K
I
L
Q
N
H
M
L
D
L
R
I
S
N
S
K
L
F
W
R
A
L
A
M
L
Q
R
F
S
GQS
K
A
R
C
I
E
S
L
L
R
A
I
H
F
P
Q
P
--------------------------
L
S
D
D
I
R
A
A
P
I
S
C
H
V
Q
V
A
H
E
K
---------------------
11
PsiBlast_PDB
58.20
20%
-75
- C1 -
4OHM
8
GCKR_HUMAN
A:
[323-579]
--------------------------------------------
P
K
I
A
T
L
M
K
S
V
S
T
S
L
E
K
K
G
H
V
Y
L
V
G
W
Q
T
L
G
I
I
A
I
M
D
G
V
E
C
I
H
T
F
G
A
D
F
R
D
V
R
G
F
L
I
----------------
F
T
F
S
Q
E
D
F
L
T
S
I
LP
S
L
T
E
I
D
T
V
V
F
I
F
T
L
D
D
-
N
L
T
E
--
V
Q
-------------
T
I
V
E
Q
V
K
E
K
T
N
H
I
Q
A
L
A
H
S
--
T
V
--
G
Q
T
L
P
I
P
-
L
K
-
K
L
F
P
S
I
I
---
S
I
T
--
W
P
LLFFEYEGN
F
I
Q
K
F
Q
R
E
L
S
T
K
W
V
L
N
T
V
S
T
G
A
H
V
L
L
G
K
I
L
Q
N
H
M
L
D
L
R
I
S
N
S
K
L
F
W
R
A
L
A
M
L
Q
R
F
S
GQS
K
A
R
C
I
E
S
L
L
R
A
I
H
F
P
Q
P
--------------------------
L
S
D
D
I
R
A
A
P
I
S
C
H
V
Q
V
A
H
E
K
---------------------
16
PsiBlast_PDB
58.07
20%
-78
- C1 -
4OP3
8
GCKR_HUMAN
A:
[323-579]
--------------------------------------------
P
K
I
A
T
L
M
K
S
V
S
T
S
L
E
K
K
G
H
V
Y
L
V
G
W
Q
T
L
G
I
I
A
I
M
D
G
V
E
C
I
H
T
F
G
A
D
F
R
D
V
R
G
F
L
I
----------------
F
T
F
S
Q
E
D
F
L
T
S
I
LP
S
L
T
E
I
D
T
V
V
F
I
F
T
L
D
D
-
N
L
T
E
--
V
Q
-------------
T
I
V
E
Q
V
K
E
K
T
N
H
I
Q
A
L
A
H
S
--
T
V
--
G
Q
T
L
P
I
P
-
L
K
-
K
L
F
P
S
I
I
---
S
I
T
--
W
P
LLFFEYEGN
F
I
Q
K
F
Q
R
E
L
S
T
K
W
V
L
N
T
V
S
T
G
A
H
V
L
L
G
K
I
L
Q
N
H
M
L
D
L
R
I
S
N
S
K
L
F
W
R
A
L
A
M
L
Q
R
F
SGQS
K
A
R
C
I
E
S
L
L
R
A
I
H
F
P
Q
P
--------------------------
L
S
D
D
I
R
A
A
P
I
S
C
H
V
Q
V
A
H
E
K
---------------------
15
PsiBlast_PDB
58.07
20%
-75
- C1 -
4OP2
7
GCKR_HUMAN
A:
[323-579]
--------------------------------------------
P
K
I
A
T
L
M
K
S
V
S
T
S
L
E
K
K
G
H
V
Y
L
V
G
W
Q
T
L
G
I
I
A
I
M
D
G
V
E
C
I
H
T
F
G
A
D
F
R
D
V
R
G
F
L
I
----------------
F
T
F
S
Q
E
D
F
L
T
S
I
LP
S
L
T
E
I
D
T
V
V
F
I
F
T
L
D
D
-
N
L
T
E
--
V
Q
-------------
T
I
V
E
Q
V
K
E
K
T
N
H
I
Q
A
L
A
H
S
--
T
V
--
G
Q
T
L
P
I
P
-
L
K
-
K
L
F
P
S
I
I
---
S
I
T
--
W
P
LLFFEYEGN
F
I
Q
K
F
Q
R
E
L
S
T
K
W
V
L
N
T
V
S
T
G
A
H
V
L
L
G
K
I
L
Q
N
H
M
L
D
L
R
I
S
N
S
K
L
F
W
R
A
L
A
M
L
Q
R
F
S
GQS
K
A
R
C
I
E
S
L
L
R
A
I
H
F
P
Q
P
--------------------------
L
S
D
D
I
R
A
A
P
I
S
C
H
V
Q
V
A
H
E
K
---------------------
18
PsiBlast_PDB
57.89
20%
-80
- C1 -
4PXS
8
GCKR_HUMAN
A:
[323-579]
--------------------------------------------
P
K
I
A
T
L
M
K
S
V
S
T
S
L
E
K
K
G
H
V
Y
L
V
G
W
Q
T
L
G
I
I
A
I
M
D
G
V
E
C
I
H
T
F
G
A
D
F
R
D
V
R
G
F
L
I
----------------
F
T
F
S
Q
E
D
F
L
T
S
I
LP
S
L
T
E
I
D
T
V
V
F
I
F
T
L
D
D
-
N
L
T
E
--
V
Q
-------------
T
I
V
E
Q
V
K
E
K
T
N
H
I
Q
A
L
A
H
S
--
T
V
--
G
Q
T
L
P
I
P
-
L
K
-
K
L
F
P
S
I
I
---
S
I
T
--
W
P
L
LFFEYEGN
F
I
Q
K
F
Q
R
E
L
S
T
K
W
V
L
N
T
V
S
T
G
A
H
V
L
L
G
K
I
L
Q
N
H
M
L
D
L
R
I
S
N
S
K
L
F
W
R
A
L
A
M
L
Q
R
F
SGQS
K
A
R
C
I
E
S
L
L
R
A
I
H
F
P
Q
P
--------------------------
L
S
D
D
I
R
A
A
P
I
S
C
H
V
Q
V
A
H
E
K
---------------------
7
PsiBlast_PDB
57.49
20%
-75
- C1 -
4MQU
7
GCKR_HUMAN
A:
[322-578]
--------------------------------------------
P
K
I
A
T
L
M
K
S
V
S
T
S
L
E
K
K
G
H
V
Y
L
V
G
W
Q
T
L
G
I
I
A
I
M
D
G
V
E
C
I
H
T
F
G
A
D
F
R
D
V
R
G
F
L
I
----------------
F
T
F
S
Q
E
D
F
L
T
S
I
LP
S
L
T
E
I
D
T
V
V
F
I
F
T
L
D
D
-
N
L
T
E
--
V
Q
-------------
T
I
V
E
Q
V
K
E
K
T
N
H
I
Q
A
L
A
H
S
--
T
V
--
G
Q
T
L
P
I
P
-
L
K
-
K
L
F
P
S
I
I
---
S
I
T
--
W
P
LLFFEYEGN
F
I
Q
K
F
Q
R
E
L
S
T
K
W
V
L
N
T
V
S
T
G
A
H
V
L
L
G
K
I
L
Q
N
H
M
L
D
L
R
I
S
N
S
K
L
F
W
R
A
L
A
M
L
Q
R
F
S
GQS
K
A
R
C
I
E
S
L
L
R
A
I
H
F
P
Q
P
--------------------------
L
S
D
D
I
R
A
A
P
I
S
C
H
V
Q
V
A
H
E
K
---------------------
19
PsiBlast_PDB
57.30
20%
-75
- C1 -
4PX2
8
GCKR_HUMAN
A:
[323-579]
--------------------------------------------
P
K
I
A
T
L
M
K
S
V
S
T
S
L
E
K
K
G
H
V
Y
L
V
G
W
Q
T
L
G
I
I
A
I
M
D
G
V
E
C
I
H
T
F
G
A
D
F
R
D
V
R
G
F
L
I
----------------
F
T
F
S
Q
E
D
F
L
T
S
I
LP
S
L
T
E
I
D
T
V
V
F
I
F
T
L
D
D
-
N
L
T
E
--
V
Q
-------------
T
I
V
E
Q
V
K
E
K
T
N
H
I
Q
A
L
A
H
S
--
T
V
--
G
Q
T
L
P
I
P
-
L
K
-
K
L
F
P
S
I
I
---
S
I
T
--
W
P
L
LFFEYEGN
F
I
Q
K
F
Q
R
E
L
S
T
K
W
V
L
N
T
V
S
T
G
A
H
V
L
L
G
K
I
L
Q
N
H
M
L
D
L
R
I
S
N
S
K
L
F
W
R
A
L
A
M
L
Q
R
F
S
GQS
K
A
R
C
I
E
S
L
L
R
A
I
H
F
P
Q
P
--------------------------
L
S
D
D
I
R
A
A
P
I
S
C
H
V
Q
V
A
H
E
K
---------------------
6
PsiBlast_PDB
57.17
20%
-78
- C1 -
4MSU
9
GCKR_HUMAN
A:
[322-578]
--------------------------------------------
P
K
I
A
T
L
M
K
S
V
S
T
S
L
E
K
K
G
H
V
Y
L
V
G
W
Q
T
L
G
I
I
A
I
M
D
G
V
E
C
I
H
T
F
G
A
D
F
R
D
V
R
G
F
L
I
----------------
F
T
F
S
Q
E
D
F
L
T
S
I
LP
S
L
T
E
I
D
T
V
V
F
I
F
T
L
D
D
-
N
L
T
E
--
V
Q
-------------
T
I
V
E
Q
V
K
E
K
T
N
H
I
Q
A
L
A
H
S
--
T
V
--
G
Q
T
L
P
I
P
-
L
K
-
K
L
F
P
S
I
I
---
S
I
T
--
W
P
LLFFEYEGN
F
I
Q
K
F
Q
R
E
L
S
T
K
W
V
L
N
T
V
S
T
G
A
H
V
L
L
G
K
I
L
Q
N
H
M
L
D
L
R
I
S
N
S
K
L
F
W
R
A
L
A
M
L
Q
R
F
S
GQS
K
A
R
C
I
E
S
L
L
R
A
I
H
F
P
Q
P
--------------------------
L
S
D
D
I
R
A
A
P
I
S
C
H
V
Q
V
A
H
E
K
---------------------