@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0206: (2016-03-13 )
MAELKLEHIKKTYDNNNTVVKDFNLHITDKEFIVFVGPSGCGKSTTLRMVAGLESITSGDFYIDGERMNDVEPKNRDIAMVFQNYALYPHMTVFENMAFGLKLRKVNKKEIEQKVNEAAEILGLTEYLGRKPKALSGGQRQRVALGRAIVRDAKVFLMDEPLSNLDAKLRVQMRTEILKLHKRLNTTTIYVTHDQTEALTMASRIVVLKDGDIMQVGTPREIYDAPNCIFVAQFIGSPAMNMLNATVEMDGLKVGTHHFKLHNKKFEKLKAAGYLDKEIILGIRAEDIHEEPIFIQTSPETQFESEVVVSELLGSEIMVHSTFQGMELISKLDSRTQVMTNDKITLAFDMNKCHFFDEKTGNRIV
Atome Classification :
(46 SA)
.........10........20--.........30........40........50........60.......----.70-----....-----...-..80........90----.........100........110.......120..--..----...130.......140.......150.......160.......170.......180..---.....190.......200.......210.......220.......230.......240.-......250---........260-.-......270-...---......280.....--..290.-....--..300.......310.......320....--.--..330.-.......340.......350.......360...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAE
L
K
L
E
H
I
K
K
T
YDNN
N
T
V
V
---
K
D
F
N
L
H
ITD
K
E
F
I
V
F
VGPSGCGKS
T
T
L
R
M
V
AG
L
E
S
ITSG
D
F
Y
IDGERM----ND------VEPK-----NR
D
-
I
A
M
V
F
Q
NYALY
P
H
-----
M
T
V
F
E
NMAF
G
-
L
K
L
RKV
N
K
K
E
I
E
Q
K
V
N
E
A
A
E
I
L
G
L
--
T
E
----
Y
LGRKPKALSGGQ
R
Q
R
V
A
L
G
R
A
I
VRD
A
K
V
F
L
MDEPLSNL
D
A
K
L
R
V
Q
M
R
T
E
I
L
K
L
H
K
RL---NT
T
T
I
Y
V
THDQT
E
A
L
T
M
A
S
R
I
V
V
LKDG
D
I
M
QVGT
P
R
E
IYDAP
N
C
I
F
V
A
Q
F
IG
S
P
A
M
N
M
L
-
N
A
T
V
E
MD
G
----
L
K
VG
T
H
H
F
K
L
H
-
N
-
K
K
F
E
K
L
K
---AAG---YLDK
E
I
I
L
G
I
RAED--IHEE
P
I
-
F
I
QT--SPETQ
F
E
S
E
V
V
V
S
E
LLGS
E
I
M
V
H
S
TF
Q
G
M
--
E
--
L
I
S
-
K
L-DSR
T
Q
V
MTND
K
I
T
L
A
F
DMN
K
C
H
F
FDEKTGNRIV
3
PsiBlast_PDB
93.59
51%
-110
- C2 -
2D62
8
?
A:
[5-370]
-
A
E
V
K
L
I
N
I
W
K
R
F
-
G
D
V
T
A
V
---
K
D
L
S
L
E
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
R
G
Q
I
Y
I
E
D
N
L
V
----
A
D
PEKG
V
F
V
P
P
K
-----
E
R
D
-
V
A
M
V
F
Q
S
Y
A
L
Y
P
H
-----
M
T
V
Y
D
N
I
A
F
P
-
L
K
L
R
K
V
P
K
Q
E
I
D
K
R
V
R
E
V
A
E
M
L
G
L
--
T
E
----
L
L
N
R
K
P
R
E
L
S
G
G
Q
R
Q
R
V
A
L
G
R
A
I
I
R
R
P
K
V
F
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
K
M
R
A
E
L
K
K
L
Q
R
Q
L
---
G
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
K
G
E
L
Q
Q
V
G
T
P
D
E
V
Y
Y
K
P
V
N
T
F
V
A
G
F
I
G
S
P
P
M
N
F
L
-
D
A
T
I
T
D
D
G
F---
L
D
F
G
E
F
K
L
K
L
L
-
Q
-
D
Q
F
E
V
L
E
---
E
E
N
---
M
V
G
K
E
V
I
F
G
I
R
P
E
D
--
V
H
D
A
S
F
T
H
I
D
V
--
P
E
E
N
T
V
K
A
T
V
D
I
I
E
N
L
G
G
E
K
I
V
H
L
R
R
G
N
I
--
S
--
F
T
A
-
K
F
-
P
K
E
S
K
V
R
E
G
D
E
V
S
V
V
F
D
M
K
K
I
H
I
F
R
K
D
T
-----
13
PsiBlast_PDB
89.16
47%
-103
- C2 -
3PUV
5
MALK_ECOLI
A:
[2-357]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
-
G
E
V
V
V
S
---
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
----
N
D
------
T
P
P
A
-----
E
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
-----
L
S
V
A
E
N
M
S
F
G
-
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
--
A
H
----
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
---
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
-
P
V
K
V
T
A
T
A
----
I
D
Q
V
Q
V
E
L
P
M
P
-
N
-
R
Q
Q
V
W
L
P
---
V
E
S
RDV
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
--
L
L
P
S
D
I
-
A
-------
D
V
I
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
--
R
Q
N
L
V
Y
-
R
Q
-
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
-------
1
PsiBlast_PDB
88.78
50%
-106
- C2 -
4TQU
-
?
S:
[2-358]
V
A
S
V
S
I
Q
N
V
V
K
R
Y
D
K
T
-
T
V
V
---
H
G
V
S
L
D
I
E
P
G
E
F
V
V
L
V
G
P
S
G
C
G
K
S
T
T
L
R
M
V
A
G
L
E
E
I
S
G
G
T
I
R
I
D
G
R
V
I
----
N
D
------
L
A
P
K
-----
D
R
D
-
V
A
M
V
F
Q
N
Y
A
L
Y
P
H
-----
L
N
V
R
D
N
I
S
F
G
-
L
R
L
K
R
T
K
K
S
V
I
D
A
A
V
K
T
A
A
D
I
L
G
L
--
Q
P
----
L
L
E
R
K
P
S
D
L
S
G
G
Q
R
Q
R
V
A
M
G
R
A
I
V
R
D
P
K
V
F
L
F
D
Q
P
L
S
N
L
D
A
K
L
R
T
Q
M
R
A
E
I
K
R
L
H
Q
R
L
---
G
T
T
V
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
R
I
V
V
M
R
D
G
L
I
E
Q
I
G
K
P
M
D
L
F
L
H
P
A
N
T
F
V
A
S
F
I
G
S
P
P
M
N
L
M
-
P
A
R
I
A
V
D
--------
S
T
Q
H
V
E
L
N
G
G
-
N
R
I
S
L
L
P
---
R
A
G
THL
A
P
G
Q
E
V
V
F
G
I
R
P
E
D
--
V
T
L
D
---
G
V
E
G
--
S
E
R
A
Q
I
K
A
T
V
D
I
V
E
P
L
G
S
E
S
I
L
H
A
T
V
G
D
H
--
S
--
L
V
V
-
K
V
-
G
G
L
N
E
V
H
P
G
D
P
V
T
L
H
V
D
L
T
R
V
H
L
F
D
A
Q
S
-----
15
PsiBlast_PDB
88.29
47%
-102
- C2 -
3PUX
5
MALK_ECOLI
A:
[2-357]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
-
G
E
V
V
V
S
---
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
----
N
D
------
T
P
P
A
-----
E
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
-----
L
S
V
A
E
N
M
S
F
G
-
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
--
A
H
----
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
---
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
-
P
V
K
V
T
A
T
A
----
I
D
Q
V
Q
V
E
L
P
M
P
-
N
-
R
Q
Q
V
W
L
P
---
V
E
S
RDV
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
--
L
L
P
S
D
I
-
A
-------
D
V
I
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
--
R
Q
N
L
V
Y
-
R
Q
-
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
-------
16
PsiBlast_PDB
88.15
47%
-104
- C2 -
3RLF
3
MALK_ECOLI
A:
[2-357]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
-
G
E
V
V
V
S
---
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
----
N
D
------
T
P
P
A
-----
E
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
-----
L
S
V
A
E
N
M
S
F
G
-
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
--
A
H
----
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
---
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
-
P
V
K
V
T
A
T
A
----
I
D
Q
V
Q
V
E
L
P
M
P
-
N
-
R
Q
Q
V
W
L
P
---
V
E
S
RDV
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
--
L
L
P
S
D
I
-
A
-------
D
V
I
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
--
R
Q
N
L
V
Y
-
R
Q
-
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
-------
19
PsiBlast_PDB
88.08
47%
-104
- C2 -
4KI0
4
?
A:
[2-357]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
-
G
E
V
V
V
S
---
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
----
N
D
------
T
P
P
A
-----
E
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
-----
L
S
V
A
E
N
M
S
F
G
-
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
--
A
H
----
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
---
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
-
P
V
K
V
T
A
T
A
----
I
D
Q
V
Q
V
E
L
P
M
P
-
N
-
R
Q
Q
V
W
L
P
---
V
E
S
RDV
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
--
L
L
P
S
D
I
-
A
-------
D
V
I
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
--
R
Q
N
L
V
Y
-
R
Q
-
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
-------
21
PsiBlast_CBE
87.72
47%
-103
- C2 -
4KI0
3
?
B:
[2-357]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
-
G
E
V
V
V
S
---
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
----
N
D
------
T
P
P
A
-----
E
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
-----
L
S
V
A
E
N
M
S
F
G
-
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
--
A
H
----
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
---
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
-
P
V
K
V
T
A
T
A
----
I
D
Q
V
Q
V
E
L
P
M
P
-
N
-
R
Q
Q
V
W
L
P
---
V
E
S
RDV
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
--
L
L
P
S
D
I
-
A
-------
D
V
I
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
--
R
QN
L
V
Y
-
R
Q
-
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
-------
22
PsiBlast_CBE
87.43
47%
-104
- C2 -
3RLF
3
MALK_ECOLI
B:
[2-357]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
-
G
E
V
V
V
S
---
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
----
N
D
------
T
P
P
A
-----
E
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
-----
L
S
V
A
E
N
M
S
F
G
-
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
--
A
H
----
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
---
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
-
P
V
K
V
T
A
T
A
----
I
D
Q
V
Q
V
E
L
P
M
P
-
N
-
R
Q
Q
V
W
L
P
---
V
E
S
RDV
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
--
L
L
P
S
D
I
-
A
-------
D
V
I
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
--
R
QN
L
V
Y
-
R
Q
-
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
-------
109
HHSearch
87.35
46%
-108
- C2 -
1V43
-
?
A:
[10-373]
M
V
E
V
K
L
E
N
L
T
K
R
F
G
N
-
F
T
A
V
---
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
D
R
D
V
----
T
Y
------
L
P
P
K
-----
D
R
N
-
I
S
M
V
F
Q
------
H
-----
M
T
V
Y
E
N
I
A
F
P
-
L
--
K
K
F
P
K
D
E
I
D
K
R
V
R
W
A
A
E
L
L
Q
I
--
E
E
----
L
L
N
R
Y
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
---
K
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
N
S
V
F
V
A
T
F
I
G
A
P
E
M
N
I
L
-
E
V
S
V
G
D
G
Y
----
L
E
G
-----
R
G
F
----
R
I
E
L
P
Q
MDL
L
K
D
---
Y
V
G
K
T
V
L
F
G
I
R
P
E
H
--
M
T
V
E
G
V
-----HM
K
R
T
A
R
L
I
G
K
V
D
F
V
E
A
L
G
T
D
T
I
L
H
V
K
F
G
D
E
--
L
--
V
K
V
-
K
L
-
P
G
H
I
P
I
E
P
G
R
E
V
K
V
I
M
D
L
D
M
I
H
V
F
D
K
D
T
E
K
A
I
V
14
PsiBlast_PDB
87.33
47%
-100
- C2 -
3PUW
5
MALK_ECOLI
A:
[2-357]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
-
G
E
V
V
V
S
---
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
----
N
D
------
T
P
P
A
-----
E
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
-----
L
S
V
A
E
N
M
S
F
G
-
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
--
A
H
----
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
---
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
-
P
V
K
V
T
A
T
A
----
I
D
Q
V
Q
V
E
L
P
M
P
-
N
-
R
Q
Q
V
W
L
P
---
V
E
S
RDV
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
--
L
L
P
S
D
I
-
A
-------
D
V
I
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
--
R
Q
N
L
V
Y
-
R
Q
-
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
-------
2
PsiBlast_PDB
86.97
50%
-105
- C2 -
4TQV
-
?
C:
[2-358]
V
A
S
V
S
I
Q
N
V
V
K
R
Y
D
K
T
-
T
V
V
---
H
G
V
S
L
D
I
E
P
G
E
F
V
V
L
V
G
P
S
G
C
G
K
S
T
T
L
R
M
V
A
G
L
E
E
I
S
G
G
T
I
R
I
D
G
R
V
I
----
N
D
------
L
A
P
K
-----
D
R
D
-
V
A
M
V
F
Q
N
Y
A
L
Y
P
H
-----
L
N
V
R
D
N
I
S
F
G
-
L
R
L
K
R
T
K
K
S
V
I
D
A
A
V
K
T
A
A
D
I
L
G
L
--
Q
P
----
L
L
E
R
K
P
S
D
L
S
G
G
Q
R
Q
R
V
A
M
G
R
A
I
V
R
D
P
K
V
F
L
F
D
Q
P
L
S
N
L
D
A
K
L
R
T
Q
M
R
A
E
I
K
R
L
H
Q
R
L
---
G
T
T
V
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
R
I
V
V
M
R
D
G
L
I
E
Q
I
G
K
P
M
D
L
F
L
H
P
A
N
T
F
V
A
S
F
I
G
S
P
P
M
N
L
M
-
P
A
R
I
A
V
D
--------
S
T
Q
H
V
E
L
N
G
G
-
N
R
I
S
L
L
P
---
R
A
G
THL
A
P
G
Q
E
V
V
F
G
I
R
P
E
D
--
V
T
L
D
---
G
V
E
G
--
S
E
R
A
Q
I
K
A
T
V
D
I
V
E
P
L
G
S
E
S
I
L
H
A
T
V
G
D
H
--
S
--
L
V
V
-
K
V
-
G
G
L
N
E
V
H
P
G
D
P
V
T
L
H
V
D
L
T
R
V
H
L
F
D
A
Q
S
-----
114
HHSearch
86.78
48%
-95
- C2 -
3RLF
3
MALK_ECOLI
A:
[2-363]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
-
V
V
V
S
---
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
----
N
D
------
T
P
P
A
-----
E
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
-----
L
S
V
A
E
N
M
S
F
G
-
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
--
A
H
----
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
---
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
-
P
V
K
V
T
A
T
A
----
I
D
Q
V
Q
V
E
L
P
M
P
-
N
R
Q
Q
V
W
L
P
V
ES-
R
D
V
---
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
--
L
L
P
S
D
I
-
A
-------
D
V
I
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
R
Q
N
--
L
V
Y
-
R
Q
-
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
A
C
R
-
33
PsiBlast_CBE
86.77
46%
-114
- C2 -
1VCI
1
?
A:
[10-373]
M
V
E
V
K
L
E
N
L
T
K
R
F
-
G
N
F
T
A
V
---
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
D
R
D
V
----
T
Y
------
L
P
P
K
-----
D
R
N
-
I
S
M
V
F
Q
------
H
-----
M
T
V
Y
E
N
I
A
F
P
-
L
--
K
K
F
P
K
D
E
I
D
K
R
V
R
W
A
A
E
L
L
Q
I
--
E
E
----
L
L
N
R
Y
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
---
K
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
N
S
V
F
V
A
T
F
I
G
A
P
E
M
N
I
L
-
E
V
S
V
G
D
G
Y
----
L
E
G
R
G
F
R
I
E
L
P
-
Q
---
M
D
L
L
K
-----
D
---
Y
V
G
K
T
V
L
F
G
I
R
P
E
H
--
M
T
V
E
G
V
---
H
M
--
K
R
T
A
R
L
I
G
K
V
D
F
V
E
A
L
G
T
D
T
I
L
H
V
K
F
-
G
D
--
E
--
L
V
K
V
K
L
-
P
G
H
I
P
I
E
P
G
R
E
V
K
V
I
M
D
L
D
M
I
H
V
F
D
K
D
T
E
K
A
I
V
10
PsiBlast_PDB
86.62
47%
-102
- C2 -
3PUY
3
MALK_ECOLI
A:
[2-357]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
-
G
E
V
V
V
S
---
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
----
N
D
------
T
P
P
A
-----
E
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
-----
L
S
V
A
E
N
M
S
F
G
-
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
--
A
H
----
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
---
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
-
P
V
K
V
T
A
T
A
----
I
D
Q
V
Q
V
E
L
P
M
P
-
N
-
R
Q
Q
V
W
L
P
---
V
E
S
RDV
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
--
L
L
P
S
D
I
-
A
-------
D
V
I
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
--
R
Q
N
L
V
Y
-
R
Q
-
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
-------
23
PsiBlast_CBE
86.58
47%
-103
- C2 -
3PUZ
2
MALK_ECOLI
B:
[2-357]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
-
G
E
V
V
V
S
---
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
----
N
D
------
T
P
P
A
-----
E
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
-----
L
S
V
A
E
N
M
S
F
G
-
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
--
A
H
----
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
---
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
-
P
V
K
V
T
A
T
A
----
I
D
Q
V
Q
V
E
L
P
M
P
-
N
-
R
Q
Q
V
W
L
P
---
V
E
S
RDV
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
--
L
L
P
S
D
I
-
A
-------
D
V
I
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
--
R
QN
L
V
Y
-
R
Q
-
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
-------
20
PsiBlast_PDB
86.24
47%
-99
- C2 -
2R6G
2
MALK_ECOLI (first)
A:
[2-357]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
-
G
E
V
V
V
S
---
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
----
N
D
------
T
P
P
A
-----
E
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
-----
L
S
V
A
E
N
M
S
F
G
-
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
--
A
H
----
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
Q
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
---
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
-
P
V
K
V
T
A
T
A
----
I
D
Q
V
Q
V
E
L
P
M
P
-
N
-
R
Q
Q
V
W
L
P
---
V
E
S
RDV
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
--
L
L
P
S
D
I
-
A
-------
D
V
I
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
--
R
Q
N
L
V
Y
-
R
Q
-
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
-------
12
PsiBlast_PDB
85.67
47%
-98
- C2 -
3PV0
-
MALK_ECOLI
A:
[2-357]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
-
G
E
V
V
V
S
---
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
----
N
D
------
T
P
P
A
-----
E
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
-----
L
S
V
A
E
N
M
S
F
G
-
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
--
A
H
----
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
---
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
-
P
V
K
V
T
A
T
A
----
I
D
Q
V
Q
V
E
L
P
M
P
-
N
-
R
Q
Q
V
W
L
P
---
V
E
S
RDV
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
--
L
L
P
S
D
I
-
A
-------
D
V
I
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
--
R
QN
L
V
Y
-
R
Q
-
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
-------
32
PsiBlast_CBE
85.38
47%
-102
- C2 -
2R6G
2
MALK_ECOLI (first)
B:
[2-357]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
-
G
E
V
V
V
S
---
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
----
N
D
------
T
P
P
A
-----
E
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
-----
L
S
V
A
E
N
M
S
F
G
-
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
--
A
H
----
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
Q
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
---
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
-
P
V
K
V
T
A
T
A
----
I
D
Q
V
Q
V
E
L
P
M
P
-
N
-
R
Q
Q
V
W
L
P
---
V
E
S
RDV
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
--
L
L
P
S
D
I
-
A
-------
D
V
I
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
--
R
QN
L
V
Y
-
R
Q
-
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
-------
34
PsiBlast_CBE
85.03
43%
-108
- C2 -
2YYZ
3
?
A:
[2-359]
-
P
S
I
R
V
V
N
L
K
K
-
Y
F
G
K
V
K
A
V
---
D
G
V
S
F
E
V
K
D
G
E
F
V
A
L
L
G
P
S
G
C
G
K
T
T
T
L
L
M
L
A
G
I
Y
K
P
T
S
G
E
I
Y
F
D
D
V
L
V
----
N
D
------
I
P
P
K
-----
Y
R
E
-
V
G
M
V
F
Q
N
Y
A
L
Y
P
H
-----
M
T
V
F
E
N
I
A
F
P
-
L
R
A
R
R
I
S
K
D
E
V
E
K
R
V
V
E
I
A
R
K
L
L
I
--
D
N
----
L
L
D
R
K
P
T
Q
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
Q
P
K
V
L
L
F
D
E
P
L
S
N
L
D
A
N
L
R
M
I
M
R
A
E
I
K
H
L
Q
Q
E
L
---
G
I
T
S
V
Y
V
T
H
D
Q
A
E
A
M
T
M
A
S
R
I
A
V
F
N
Q
G
K
L
V
Q
Y
G
T
P
D
E
V
Y
D
S
P
K
N
M
F
V
A
S
F
I
G
N
P
P
T
N
F
L
R
D
F
S
V
S
V
E
N
K
Q
T
I
L
K
R
D
D
V
I
I
K
L
P
-
E
-
P
V
D
V
K
L
-------------
K
E
V
V
V
G
I
R
P
E
H
C
R
I
S
R
E
R
V
---------
E
N
S
I
P
G
V
V
Y
V
V
E
P
L
G
R
D
I
I
V
N
V
K
T
E
K
G
--
E
--
I
I
K
-
V
F
G
D
T
G
K
A
P
Q
P
G
E
N
V
F
L
V
P
D
L
R
K
I
H
L
F
N
P
E
T
E
E
T
I
L
18
PsiBlast_PDB
84.98
47%
-102
- C2 -
4KHZ
-
?
A:
[2-357]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
-
G
E
V
V
V
S
---
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
----
N
D
------
T
P
P
A
-----
E
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
-----
L
S
V
A
E
N
M
S
F
G
-
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
--
A
H
----
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
---
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
-
P
V
K
V
T
A
T
A
----
I
D
Q
V
Q
V
E
L
P
M
P
-
N
-
R
Q
Q
V
W
L
P
---
V
E
S
RDV
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
--
L
L
P
S
D
I
-
A
-------
D
V
I
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
--
R
Q
N
L
V
Y
-
R
Q
-
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
-------
48
PsiBlast_CBE
66.82
36%
-111
- C2 -
3FVQ
3
FBPC_NEIG1
B:
[3-240]
-
A
A
L
H
I
G
H
L
S
K
S
F
-
Q
N
T
P
V
L
---
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
FSKN
T
N
------
L
P
V
R
-----
E
R
R
-
L
G
Y
L
V
Q
E
G
V
L
F
P
H
-----
L
T
V
Y
R
N
I
A
Y
G
-
L
G
N
G
K
G
R
T
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
G
I
--
S
E
----
L
A
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
---
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
G
---------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
65.42
36%
-108
- C2 -
3FVQ
3
FBPC_NEIG1
A:
[3-245]
-
A
A
L
H
I
G
H
L
S
K
S
F
-
Q
N
T
P
V
L
---
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
FSKN
T
N
------
L
P
V
R
-----
E
R
R
-
L
G
Y
L
V
Q
E
G
V
L
F
P
H
-----
L
T
V
Y
R
N
I
A
Y
G
-
L
G
N
G
K
G
R
T
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
G
I
--
S
E
----
L
A
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
---
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
G
---------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
59.12
34%
-95
- C2 -
2OLK
2
?
B:
[25-251]
---
I
D
V
H
Q
L
K
K
S
F
-
G
S
L
E
V
L
---
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
KAKD
T
N
------
L
N
K
V
-----
R
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
-----
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
--
K
D
----
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
M
K
Q
L
ANE
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
59.09
34%
-98
- C2 -
3C41
3
?
K:
[4-230]
---
I
D
V
H
Q
L
K
K
S
F
-
G
S
L
E
V
L
---
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
KAKD
T
N
------
L
N
K
V
-----
R
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
-----
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
--
K
D
----
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
M
K
Q
L
ANE
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
58.20
34%
-93
- C2 -
2OLK
1
?
D:
[25-251]
---
I
D
V
H
Q
L
K
K
S
F
-
G
S
L
E
V
L
---
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
KAKD
T
N
------
L
N
K
V
-----
R
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
-----
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
--
K
D
----
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
M
K
Q
L
ANE
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
58.01
34%
-99
- C2 -
3C4J
4
?
B:
[25-251]
---
I
D
V
H
Q
L
K
K
S
F
-
G
S
L
E
V
L
---
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
KAKD
T
N
------
L
N
K
V
-----
R
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
-----
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
--
K
D
----
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
M
K
Q
L
ANE
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
57.49
34%
-97
- C2 -
3C4J
3
?
A:
[25-251]
---
I
D
V
H
Q
L
K
K
S
F
-
G
S
L
E
V
L
---
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
KAKD
T
N
------
L
N
K
V
-----
R
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
-----
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
--
K
D
----
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
57.43
34%
-94
- C2 -
2OLJ
4
?
A:
[25-251]
---
I
D
V
H
Q
L
K
K
S
F
-
G
S
L
E
V
L
---
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
KAKD
T
N
------
L
N
K
V
-----
R
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
-----
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
--
K
D
----
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
57.17
34%
-93
- C2 -
2OLK
1
?
A:
[25-251]
---
I
D
V
H
Q
L
K
K
S
F
-
G
S
L
E
V
L
---
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
KAK
D
T
N
------
L
N
K
V
-----
R
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
-----
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
--
K
D
----
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
57.01
34%
-89
- C2 -
3C41
3
?
J:
[4-230]
---
I
D
V
H
Q
L
K
K
S
F
-
G
S
L
E
V
L
---
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
KAKD
T
N
------
L
N
K
V
-----
R
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
-----
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
--
K
D
----
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
M
K
Q
L
ANE
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
57.01
34%
-92
- C2 -
2OLK
1
?
C:
[25-251]
---
I
D
V
H
Q
L
K
K
S
F
-
G
S
L
E
V
L
---
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
KAKD
T
N
------
L
N
K
V
-----
R
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
-----
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
--
K
D
----
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
M
K
Q
L
ANE
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
56.73
34%
-96
- C2 -
2Q0H
4
?
B:
[25-251]
---
I
D
V
H
Q
L
K
K
S
F
-
G
S
L
E
V
L
---
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
KAKD
T
N
------
L
N
K
V
-----
R
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
-----
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
--
K
D
----
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
56.53
34%
-86
- C2 -
2OLJ
3
?
B:
[25-251]
---
I
D
V
H
Q
L
K
K
S
F
-
G
S
L
E
V
L
---
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
KAKD
T
N
------
L
N
K
V
-----
R
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
-----
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
--
K
D
----
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
M
K
Q
L
ANE
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
56.33
37%
-102
- C2 -
4YMV
1
?
J:
[16-224]
------------------
V
L
---
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
----
N
N
GKVN--
I
N
K
V
-----
R
Q
K
-
V
G
M
V
F
Q
H
F
N
L
F
P
H
-----
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
--
L
D
----
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
K
E
V
L
N
V
M
K
Q
L
ANE
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
56.31
34%
-90
- C2 -
2Q0H
4
?
A:
[25-251]
---
I
D
V
H
Q
L
K
K
S
F
-
G
S
L
E
V
L
---
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
KAKD
T
N
------
L
N
K
V
-----
R
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
-----
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
--
K
D
----
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
55.99
36%
-99
- C2 -
4U00
3
?
A:
[19-230]
------------------
V
L
---
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
----
K
D
DRA---
L
R
E
I
-----
R
R
E
-
V
G
M
V
F
Q
Q
F
N
L
F
P
H
-----
M
T
V
L
E
N
V
T
L
A
P
M
R
V
R
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
--
L
D
----
Q
A
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
55.63
37%
-98
- C2 -
4YMV
1
?
A:
[16-224]
------------------
V
L
---
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
----
N
N
GKVN--
I
N
K
V
-----
R
Q
K
-
V
G
M
V
F
Q
H
F
N
L
F
P
H
-----
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
--
L
D
----
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
54.06
37%
-103
- C2 -
4YMU
2
?
A:
[16-224]
------------------
V
L
---
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
----
N
N
GKVN--
I
N
K
V
-----
R
Q
K
-
V
G
M
V
F
Q
H
F
N
L
F
P
H
-----
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
--
L
D
----
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
53.68
37%
-103
- C2 -
4YMU
2
?
J:
[16-224]
------------------
V
L
---
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
----
N
N
GKVN--
I
N
K
V
-----
R
Q
K
-
V
G
M
V
F
Q
H
F
N
L
F
P
H
-----
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
--
L
D
----
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
K
E
V
L
N
V
M
K
Q
L
ANE
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
52.43
34%
-83
- C2 -
3TIF
7
Y796_METJA
A:
[2-223]
---
V
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
AL
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
----
N
D
------
L
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
-----
L
T
A
L
E
N
V
E
L
P
-
L
I
F
K
Y
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
--
A
E
LEER
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
---
G
K
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
51.96
34%
-81
- C2 -
1L2T
4
Y796_METJA
B:
[2-223]
---
I
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
YAL
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
----
N
D
------
L
D
D
D
ELTKI
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
-----
L
T
A
L
E
N
V
E
L
P
-
L
I
F
K
Y
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
--
A
E
LEER
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
---
G
K
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
51.93
34%
-87
- C2 -
3TIF
7
Y796_METJA
B:
[2-223]
---
V
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
YAL
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
----
N
D
------
L
D
D
D
ELTKI
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
-----
L
T
A
L
E
N
V
E
L
P
-
L
I
F
K
Y
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
--
A
E
LEER
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
---
G
K
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
51.21
34%
-84
- C2 -
1L2T
4
Y796_METJA
A:
[2-223]
---
I
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
AL
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
----
N
D
------
L
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
-----
L
T
A
L
E
N
V
E
L
P
-
L
I
F
K
Y
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
--
A
E
LEER
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
---
G
K
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
50.40
33%
-86
- C2 -
4HLU
2
ECFA2_THEMA
A:
[25-226]
-------------------
L
---
E
N
V
S
L
V
I
N
E
G
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
V
A
G
L
I
E
P
T
S
G
D
V
L
Y
D
G
E
R
K
----
K
G
------
Y
E
I
R
------
R
N
-
I
G
I
A
F
Q
----
Y
P
E
DQFFA
E
R
V
F
D
E
V
A
F
A
-
V
K
N
F
Y
P
D
R
D
P
V
P
L
-
V
K
K
A
M
E
F
V
G
L
DF
D
S
----
F
K
D
R
V
P
F
F
L
S
G
G
E
K
R
R
V
A
I
A
S
V
I
V
H
E
P
D
I
L
I
L
D
E
P
L
V
G
L
D
R
E
G
K
T
D
L
-
L
R
I
V
E
K
W
K
T
L
---
G
K
T
V
I
L
I
S
H
D
I
E
T
V
I
N
H
V
D
R
V
V
V
L
E
K
G
K
K
V
F
D
G
T
R
M
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
50.03
33%
-86
- C2 -
4HLU
3
ECFA2_THEMA
B:
[25-226]
-------------------
L
---
E
N
V
S
L
V
I
N
E
G
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
V
A
G
L
I
E
P
T
S
G
D
V
L
Y
D
G
E
R
K
----
K
G
------
Y
E
I
R
------
R
N
-
I
G
I
A
F
Q
----
Y
P
E
DQFFA
E
R
V
F
D
E
V
A
F
A
-
V
K
N
F
Y
P
D
R
D
P
V
P
L
-
V
K
K
A
M
E
F
V
G
L
DF
D
S
----
F
K
D
R
V
P
F
F
L
S
G
G
E
K
R
R
V
A
I
A
S
V
I
V
H
E
P
D
I
L
I
L
D
E
P
L
V
G
L
D
R
E
G
K
T
D
L
-
L
R
I
V
E
K
W
K
T
L
---
G
K
T
V
I
L
I
S
H
D
I
E
T
V
I
N
H
V
D
R
V
V
V
L
E
K
G
K
K
V
F
D
G
T
R
M
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
46.90
33%
-86
- C2 -
4ZIR
5
ECFA2_THEMA
A:
[24-225]
-------------------
L
---
E
N
V
S
L
V
I
N
E
G
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
V
A
G
L
I
E
P
T
S
G
D
V
L
Y
D
G
E
------
K
G
------
Y
E
I
R
------
R
N
-
I
G
I
A
F
Q
----
Y
P
E
DQFFA
E
R
V
F
D
E
V
A
F
A
-
V
K
N
F
Y
P
D
R
D
P
V
P
L
-
V
K
K
A
M
E
F
V
G
L
DF
D
S
----
F
K
D
R
V
P
F
F
L
S
G
G
E
K
R
R
V
A
I
A
S
V
I
V
H
E
P
D
I
L
I
L
D
E
P
L
V
G
L
D
R
E
G
K
T
D
L
-
L
R
I
V
E
K
W
K
T
L
---
G
K
T
V
I
L
I
S
H
D
I
E
T
V
I
N
H
V
D
R
V
V
V
L
E
K
G
K
K
V
F
D
G
T
R
M
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------