@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0297: (2016-03-14 )
MLKFENVTKSFKDGNRNIEAVKDTNFEINKGDIIALVGPSGSGKSTFLTMAGALQTPTSGHILINNQDITTMKQKALAKVRMSEIGFILQATNLVPFLTVKQQFTLLKKKNKNVMSNEDYQQLMSQLGLTSLLNKLPSEISGGQKQRVAIAKALYTNPSIILADEPTAALDTENAIEVIKILRDQAKKRKKACIIVTHDERLKAYCDRSYHMKDGVLNLENETVE
Atome Classification :
(46 SA)
---.........10........-20........30........40........50........60........70........80........90........100--.--...----..---.110----.--.--.....120--..---......130-.----......-----------.140.......150.......160.......170.......180.......190.......-200.-.-......210.......220...---------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---ML
K
F
E
N
V
T
K
S
F
KDGNR
N
I
E
-
A
VKDTN
F
E
INKG
D
I
I
A
L
VGPSGSG
K
S
T
F
L
T
M
AGALQTPTS
G
H
I
L
I
NNQ
D
I
T
T
M
K
Q
K
A
L
A
K
V
R
M
S
EI
G
F
I
L
Q
ATNLVP
F
L
T
V
K
Q
--
Q
--
F
T
L
----
L
K
---KKNK----N--V--MS
N
E
D
Y
Q
---
Q
L
---
M
S
QL
G
L
T
-
S
-
L
----
L
N
K
L
P
S
-----------
E
ISGGQ
K
Q
R
V
A
I
A
K
A
LYTNP
S
I
I
L
ADEPTAALD
T
E
N
A
I
E
V
I
K
I
L
R
D
Q
A
K
KRK
K
A
C
I
I
V
T
H
D
-
E
-
R
L
-
K
-
A
Y
C
DRSYHMKD
G
V
L
NLENETVE---------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
96.27
38%
-91
- C1 -
1L2T
4
Y796_METJA
A:
[1-226]
---
M
I
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
-
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
--
N
--
V
E
L
P---
L
I
---
F
K
Y
R
----
G
--
A
--
M
S
G
E
E
R
R
K
--
R
A
---
L
E
C
L
K
M
A
-
E
-
L
EERF
A
N
H
K
P
N
-----------
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
-
I
-
N
V
-
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
E
--------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
94.29
38%
-92
- C1 -
1L2T
4
Y796_METJA
B:
[1-226]
---
M
I
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
-
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
--
N
--
V
E
L
P---
L
I
---
F
K
Y
R
----
G
--
A
--
M
S
G
E
E
R
R
K--
R
A
---
L
E
C
L
K
M
A
-
E
-
L
EERF
A
N
H
K
P
N
-----------
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
-
I
-
N
V
-
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
E
--------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
93.59
38%
-93
- C1 -
3TIF
7
Y796_METJA
A:
[1-226]
---
M
V
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
-
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
--
N
--
V
E
L
P---
L
I
---
F
K
Y
R
----
G
--
A
--
M
S
G
E
E
R
R
K
--
R
A
---
L
E
C
L
K
M
A
-
E
-
L
EERF
A
N
H
K
P
N
-----------
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
-
I
-
N
V
-
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
E
--------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
93.21
38%
-95
- C1 -
3TIF
7
Y796_METJA
B:
[1-226]
---
M
V
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
-
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
--
N
--
V
E
L
P---
L
I
---
F
K
Y
R
----
G
--
A
--
M
S
G
E
E
R
R
K--
R
A
---
L
E
C
L
K
M
A
-
E
-
L
EERF
A
N
H
K
P
N
-----------
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
-
I
-
N
V
-
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
E
--------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
90.86
35%
-96
- C1 -
3TUI
1
METN_ECOLI
C:
[24-248]
---
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
-
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
--
N
--
V
A
L
PLE-
L
D
---
N
T
P
K
----
D
--
E
--
V
K
R
R
-
V
T
---
E
L
---
L
S
L
V
G
L
G
-
D
-
K
----
H
D
S
Y
P
S
-----------
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
-
V
V
-
K
-
R
I
C
D
C
V
A
V
I
S
N
G
E
L
-
I
E
Q
D
T
V
----------------------------------------------------------------------------------------------------------------------------
129
HHSearch
89.81
36%
-88
- C1 -
3TIF
7
Y796_METJA
A:
[1-230]
---
M
V
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
-
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
--
N
--
V
E
L
----
P
L
---
I
F
K
Y
R
G
A
M
S
--
G
E
-
E
R
R
K
R
A
L
---
E
C
---
L
K
M
A
E
L
E
-
E
R
F
----
A
N
H
K
P
N
-----------
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
-
I
-
N
V
-
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
E
E
K
L
R
----------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
89.60
35%
-97
- C1 -
3TUZ
1
METN_ECOLI
H:
[24-248]
---
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
-
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
--
N
--
V
A
L
PLE-
L
D
---
N
T
P
K
----
D
--
E
--
V
K
R
R
-
V
T
---
E
L
---
L
S
L
V
G
L
G
-
D
-
K
----
H
D
S
Y
P
S
-----------
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
-
V
V
-
K
-
R
I
C
D
C
V
A
V
I
S
N
G
E
L
-
I
E
Q
D
T
V
----------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
89.27
35%
-98
- C1 -
3TUZ
1
METN_ECOLI
C:
[24-248]
---
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
-
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
--
N
--
V
A
L
PLE-
L
D
---
N
T
P
K
----
D
--
E
--
V
K
R
R
-
V
T
---
E
L
---
L
S
L
V
G
L
G
-
D
-
K
----
H
D
S
Y
P
S
-----------
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
-
V
V
-
K
-
R
I
C
D
C
V
A
V
I
S
N
G
E
L
-
I
E
Q
D
T
V
----------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
88.79
35%
-91
- C1 -
3TUI
1
METN_ECOLI
D:
[24-248]
---
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
-
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
--
N
--
V
A
L
PLE-
L
D
---
N
T
P
K
----
D
--
E
--
V
K
R
R
-
V
T
---
E
L
---
L
S
L
V
G
L
G
-
D
-
K
----
H
D
S
Y
P
S
-----------
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
-
V
V
-
K
-
R
I
C
D
C
V
A
V
I
S
N
G
E
L
-
I
E
Q
D
T
V
----------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
88.68
35%
-94
- C1 -
3DHW
-
METN_ECOLI
C:
[1-225]
---
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
-
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
--
N
--
V
A
L
PLE-
L
D
---
N
T
P
K
----
D
--
E
--
V
K
R
R
-
V
T
---
E
L
---
L
S
L
V
G
L
G
-
D
-
K
----
H
D
S
Y
P
S
-----------
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
E
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
-
V
V
-
K
-
R
I
C
D
C
V
A
V
I
S
N
G
E
L
-
I
E
Q
D
T
V
----------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
88.32
35%
-93
- C1 -
3TUI
1
METN_ECOLI
G:
[24-248]
---
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
-
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
--
N
--
V
A
L
PLE-
L
D
---
N
T
P
K
----
D
--
E
--
V
K
R
R
-
V
T
---
E
L
---
L
S
L
V
G
L
G
-
D
-
K
----
H
D
S
Y
P
S
-----------
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
-
V
V
-
K
-
R
I
C
D
C
V
A
V
I
S
N
G
E
L
-
I
E
Q
D
T
V
----------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
87.65
35%
-94
- C1 -
3TUZ
1
METN_ECOLI
G:
[24-248]
---
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
-
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
--
N
--
V
A
L
PLE-
L
D
---
N
T
P
K
----
D
--
E
--
V
K
R
R
-
V
T
---
E
L
---
L
S
L
V
G
L
G
-
D
-
K
----
H
D
S
Y
P
S
-----------
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
-
V
V
-
K
-
R
I
C
D
C
V
A
V
I
S
N
G
E
L
-
I
E
Q
D
T
V
----------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
87.57
35%
-101
- C1 -
3TUI
1
METN_ECOLI
H:
[24-248]
---
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
-
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
--
N
--
V
A
L
PLE-
L
D
---
N
T
P
K
----
D
--
E
--
V
K
R
R
-
V
T
---
E
L
---
L
S
L
V
G
L
G
-
D
-
K
----
H
D
S
Y
P
S
-----------
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
-
V
V
-
K
-
R
I
C
D
C
V
A
V
I
S
N
G
E
L
-
I
E
Q
D
T
V
----------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
87.35
35%
-91
- C1 -
3TUZ
1
METN_ECOLI
D:
[24-248]
---
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
-
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
--
N
--
V
A
L
PLE-
L
D
---
N
T
P
K
----
D
--
E
--
V
K
R
R
-
V
T
---
E
L
---
L
S
L
V
G
L
G
-
D
-
K
----
H
D
S
Y
P
S
-----------
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
-
V
V
-
K
-
R
I
C
D
C
V
A
V
I
S
N
G
E
L
-
I
E
Q
D
T
V
----------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
86.98
37%
-85
- C1 -
1F3O
2
Y796_METJA
A:
[2-226]
----
I
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
-
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
--
L
P
L
----
I
F
---
K
Y
R
G
----
A
--
M
--
S
G
E
E
R
R
K
---
R
A
---
L
E
C
L
K
M
A
-
E
-
L
EERF
A
N
H
K
P
N
-----------
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
E
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
-
I
-
N
V
-
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
E
--------------------------------------------------------------------------------------------------------------------------------
112
HHSearch
84.50
33%
-87
* C1 *
3TUI
1
METN_ECOLI
C:
[24-249]
---
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
-
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
--
N
--
V
A
L
----
P
L
---
E
L
D
N
----
T
--
P
KD
E
V
K
R
R
V
T
---
E
L
---
L
S
L
V
G
L
G
-
D
-
K
----
H
D
S
Y
P
S
-----------
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
-
M
-
D
V
-
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
----------------------------------------------------------------------------------------------------------------------------
128
HHSearch
82.48
34%
-87
- C1 -
2PCJ
-
LOLD_AQUAE
A:
[4-224]
---
I
L
R
A
E
N
I
K
K
V
I
R
G
----
Y
E
-
I
L
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
G
L
L
D
A
P
T
E
G
K
V
F
L
E
G
K
E
V
D
Y
T
N
E
K
E
L
S
L
L
R
N
R
K
L
G
F
V
F
Q
F
H
Y
L
I
P
E
L
T
A
L
E
--
N
--
V
I
V
----
P
M
---
L
K
M
G
----
K
P
K
K
--
E
A
K
E
R
G
E
---
Y
L
---
L
S
E
L
G
L
G
-
D
-
K
----
L
S
R
K
P
Y
-----------
E
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
K
R
V
M
D
I
F
L
K
I
N
-
E
G
G
T
S
I
V
M
V
T
H
E
-
R
-
E
L
-
A
-
E
L
T
H
R
T
L
E
M
K
D
G
K
V
V
G
E
I
T
R
V
----------------------------------------------------------------------------------------------------------------------------
133
Fugue
82.26
33%
-90
- C1 -
3TUZ
3
METN_ECOLI
H:
[23-362]
--H
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
-
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
NV
A
--
L
P
L
----
E
L
---
D
N
T
P
----
K
--
D
--
E
V
K
R
R
V
T
---
E
L
---
L
S
L
V
G
L
G
-
D
-
K
----
H
D
S
Y
P
S
-----------
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
-
V
V
-
K
-
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
VFSHPKTPLAQKFIQSTLHLDIPEDYQERLQAEPFTDCVPMLRLEFTGQSVDAPLLSETARRFNVNNNIISAQMDYAGGVKFGIMLTEMHGTQQDTQAAIAWLQEHHVKVEV-----------
138
Fugue
81.68
31%
-80
- C1 -
1Z47
1
?
A:
[11-355]
GSM
T
I
E
F
V
G
V
E
K
I
Y
P
G
G
A
---
R
-
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
K
R
V
T
D
L
P
P
Q
K
------
R
N
V
G
L
V
F
Q
N
Y
A
L
F
Q
H
M
T
V
Y
D
--
N
V
S
F
G
L
----
R
E
---
K
R
V
P
----
K
--
D
--
E
M
D
A
R
V
R
---
E
L
---
L
R
F
M
R
L
E
-
S
-
Y
----
A
N
R
F
P
H
-----------
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
-
Q
E
E
A
-
L
-
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
EKPGT
L
F
V
A
S
F
IGE
S
N
V
W
T
R
A
V
Q
NG
R
I
E
V
AG
A
A
L
P
V
DPAVSEG
S
E
V
A
V
V
V
R
PKD
V
E
L
Q
P
A
S
EREAHAQVV
R
S
A
F
KGS
Y
S
A
C
W
I
R
T
KD
G
E
V
W
E
V
H
V
P
SADRHRWSPG
A
W
V
H
M
N
V
T
R
W
F
I
F
P
R
79
PsiBlast_CBE
81.49
32%
-85
- C1 -
3GFO
1
ECFA3_CLOP1
A:
[7-220]
---
I
L
K
V
E
E
L
N
Y
N
Y
S
D
G
T
H
----
A
L
K
G
I
N
M
N
I
K
R
G
E
V
T
A
I
L
G
G
N
G
V
G
K
S
T
L
F
Q
N
F
N
G
I
L
K
P
S
S
G
R
I
L
F
D
N
K
P
I
D
-
Y
S
R
K
G
I
M
K
L
R
E
S
-
I
G
I
V
F
Q
D
P
D
N
Q
L
F
S
A
S
V
Y
--
Q
--
D
V
S
----
F
G
---
A
V
N
M
----
K
--
L
--
P
E
D
E
I
R
K
---
R
V
D
N
A
L
K
R
T
G
I
E
-
H
-
L
----
K
D
K
P
T
H
-----------
C
L
S
F
G
Q
K
K
R
V
A
I
A
G
V
L
V
M
E
P
K
V
L
I
L
D
E
P
T
A
G
L
D
P
M
G
V
S
E
I
M
K
L
L
V
E
M
Q
K
E
L
G
I
T
I
I
I
A
T
H
D
I
D
-
I
V
-
P
-
L
Y
C
D
N
V
F
V
M
K
E
G
-------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
77.74
36%
-99
- C1 -
4YMU
2
?
A:
[1-214]
---
M
I
F
V
N
D
V
Y
K
N
F
G
----
S
L
E
-
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
K
V
N
-
I
N
K
V
R
-
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
--
N
--
I
T
L
APVK
V
K
---
K
M
N
K
----
K
-----
E
A
E
E
L
A
V
---
D
L
---
L
A
K
V
G
L
L
-
D
-
K
----
K
D
Q
Y
P
I
-----------
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
-
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
-
M
-
G
F
A
R
-
E
V
G
D
R
V
I
F
M
D
D
G
V
I
-----------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
76.31
36%
-96
- C1 -
4YMU
2
?
J:
[1-214]
---
M
I
F
V
N
D
V
Y
K
N
F
G
----
S
L
E
-
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
K
V
N
-
I
N
K
V
R
-
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
--
N
--
I
T
L
APVK
V
K
---
K
M
N
K
----
K
-----
E
A
E
E
L
A
V
---
D
L
---
L
A
K
V
G
L
L
-
D
-
K
----
K
D
Q
Y
P
I
-----------
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
-
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
-
M
-
G
F
A
R
-
E
V
G
D
R
V
I
F
M
D
D
G
V
I
-----------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
75.00
31%
-95
- C1 -
4U00
3
?
A:
[4-214]
---
I
I
R
I
R
N
L
H
K
W
F
G
P
----
L
H
-
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
--
L
S
V
K
D
D
R
A
L
R
E
I
R
-
R
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
--
N
--
V
T
L
----
A
P
---
M
R
V
R
----
R
--
W
--
P
R
E
K
A
E
K
K
A
L
E
L
---
L
E
R
V
G
I
L
-
D
-
Q
----
A
R
K
Y
P
A
-----------
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
-
M
-
G
F
A
R
-
E
V
A
D
R
V
V
F
M
D
G
G
-------------------------------------------------------------------------------------------------------------------------------------
132
HHSearch
74.68
35%
-83
- C1 -
2OLJ
4
?
A:
[25-245]
----
I
D
V
H
Q
L
K
K
S
F
G
S
----
L
E
-
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
-
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
--
N
--
I
T
L
----
A
P
---
M
K
V
R
KWP-
R
--
E
--
K
A
E
A
K
A
M
---
E
L
---
L
D
K
V
G
L
K
-
D
-
K
----
A
H
A
Y
P
D
-----------
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
G
M
T
M
V
V
V
T
H
E
-
M
-
G
F
-
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
---------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
74.65
36%
-95
- C1 -
4YMV
1
?
J:
[1-214]
---
M
I
F
V
N
D
V
Y
K
N
F
G
----
S
L
E
-
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
K
V
N
-
I
N
K
V
R
-
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
--
N
--
I
T
L
APVK
V
K
---
K
M
N
K
----
K
-----
E
A
E
E
L
A
V
---
D
L
---
L
A
K
V
G
L
L
-
D
-
K
----
K
D
Q
Y
P
I
-----------
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
-
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
-
M
-
G
F
A
R
-
E
V
G
D
R
V
I
F
M
D
D
G
V
I
-----------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
74.08
32%
-85
- C1 -
3NHA
4
A:
[54-266]
----
I
E
F
E
N
V
H
F
S
Y
A
D
-
R
---
E
-
T
L
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
S
G
C
I
R
I
D
G
Q
D
I
S
Q
V
T
Q
A
S
L
----
R
S
H
I
G
V
V
P
Q
D
T
V
L
F
N
D
-
T
I
A
D
--
N
--
I
-----------
R
Y
G
R
----
V
--
T
--
A
G
N
D
E
V
E
---
A
A
---
A
Q
A
A
G
I
H
-
D
-
A
----
I
M
A
F
P
E
GYRTQVGERGL
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
A
S
L
A
K
V
C
A
N
R
--
T
T
I
V
V
A
H
R
-
L
-
S
T
-
V
-
V
N
A
D
Q
I
L
V
I
K
D
G
C
I
-----------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
74.03
36%
-97
- C1 -
4YMV
1
?
A:
[1-214]
---
M
I
F
V
N
D
V
Y
K
N
F
G
----
S
L
E
-
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
K
V
N
-
I
N
K
V
R
-
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
--
N
--
I
T
L
APVK
V
K
---
K
M
N
K
----
K
-----
E
A
E
E
L
A
V
---
D
L
---
L
A
K
V
G
L
L
-
D
-
K
----
K
D
Q
Y
P
I
-----------
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
-
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
-
M
-
G
F
A
R
-
E
V
G
D
R
V
I
F
M
D
D
G
V
I
-----------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
73.93
32%
-90
- C1 -
3NHB
3
A:
[54-266]
----
I
E
F
E
N
V
H
F
S
Y
A
D
-
R
---
E
-
T
L
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
S
G
C
I
R
I
D
G
Q
D
I
S
Q
V
T
Q
A
S
L
----
R
S
H
I
G
V
V
P
Q
D
T
V
L
F
N
D
-
T
I
A
D
--
N
--
I
-----------
R
Y
G
R
----
V
--
T
--
A
G
N
D
E
V
E
---
A
A
---
A
Q
A
A
G
I
H
-
D
-
A
----
I
M
A
F
P
E
GYRTQVGERGL
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
A
S
L
A
K
V
C
A
N
R
--
T
T
I
V
V
A
H
R
-
L
-
S
T
-
V
-
V
N
A
D
Q
I
L
V
I
K
D
G
C
I
-----------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
73.44
34%
-92
- C1 -
2OLK
1
?
A:
[24-237]
---
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
L
E
-
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
-
K
D
T
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
--
N
--
I
T
L
----
A
P
MKV
R
K
W
P
----
R
--
E
--
K
A
E
A
K
A
M
---
E
L
---
L
D
K
V
G
L
K
-
D
-
K
----
A
H
A
Y
P
D
-----------
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
-
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
-
M
-
G
F
A
R
-
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
-----------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
73.00
32%
-85
- C1 -
3NH9
3
A:
[54-266]
----
I
E
F
E
N
V
H
F
S
Y
A
D
G
R
---
E
-
T
L
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
S
G
C
I
R
I
D
G
Q
D
I
S
Q
V
T
Q
A
S
L
----
R
S
H
I
G
V
V
P
Q
D
T
V
L
F
N
D
-
T
I
A
D
--
N
--
I
-----------
R
Y
G
R
----
V
--
T
--
A
G
N
D
E
V
E
---
A
A
---
A
Q
A
A
G
I
H
-
D
-
A
----
I
M
A
F
P
E
GYR
T
Q
V
G
ER
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
A
S
L
A
K
V
C
A
N
R
--
T
T
I
V
V
A
H
R
-
L
-
S
T
-
V
-
V
N
A
D
Q
I
L
V
I
K
D
G
C
I
-----------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
72.20
34%
-92
- C1 -
2OLJ
4
?
A:
[24-237]
---
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
L
E
-
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
-
K
D
T
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
--
N
--
I
T
L
----
A
P
MKV
R
K
W
P
----
R
--
E
--
K
A
E
A
K
A
M
---
E
L
---
L
D
K
V
G
L
K
-
D
-
K
----
A
H
A
Y
P
D
-----------
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
-
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
-
M
-
G
F
A
R
-
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
-----------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
72.17
34%
-90
- C1 -
2OLK
2
?
B:
[24-237]
---
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
L
E
-
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
-
K
D
T
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
--
N
--
I
T
L
----
A
P
MKV
R
K
W
P
----
R
--
E
--
K
A
E
A
K
A
M
---
E
L
---
L
D
K
V
G
L
K
-
D
-
K
----
A
H
A
Y
P
D
-----------
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
-
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
-
M
-
G
F
A
R
-
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
-----------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
72.00
34%
-89
- C1 -
2OLK
1
?
C:
[24-237]
---
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
L
E
-
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
-
K
D
T
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
--
N
--
I
T
L
----
A
P
MKV
R
K
W
P
----
R
--
E
--
K
A
E
A
K
A
M
---
E
L
---
L
D
K
V
G
L
K
-
D
-
K
----
A
H
A
Y
P
D
-----------
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
-
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
-
M
-
G
F
A
R
-
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
-----------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
71.97
34%
-98
- C1 -
3C4J
4
?
B:
[24-237]
---
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
L
E
-
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
-
K
D
T
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
--
N
--
I
T
L
----
A
P
MKV
R
K
W
P
----
R
--
E
--
K
A
E
A
K
A
M
---
E
L
---
L
D
K
V
G
L
K
-
D
-
K
----
A
H
A
Y
P
D
-----------
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
-
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
-
M
-
G
F
A
R
-
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
-----------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
71.62
34%
-92
- C1 -
2OLK
1
?
D:
[24-237]
---
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
L
E
-
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
-
K
D
T
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
--
N
--
I
T
L
----
A
P
MKV
R
K
W
P
----
R
--
E
--
K
A
E
A
K
A
M
---
E
L
---
L
D
K
V
G
L
K
-
D
-
K
----
A
H
A
Y
P
D
-----------
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
-
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
-
M
-
G
F
A
R
-
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
-----------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
71.19
34%
-93
- C1 -
3C41
3
?
K:
[3-216]
---
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
L
E
-
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
-
K
D
T
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
--
N
--
I
T
L
----
A
P
MKV
R
K
W
P
----
R
--
E
--
K
A
E
A
K
A
M
---
E
L
---
L
D
K
V
G
L
K
-
D
-
K
----
A
H
A
Y
P
D
-----------
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
-
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
-
M
-
G
F
A
R
-
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
-----------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
71.04
34%
-91
- C1 -
3C4J
3
?
A:
[24-237]
---
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
L
E
-
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
-
K
D
T
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
--
N
--
I
T
L
----
A
P
M
K
V
R
K
W
P
----
R
--
E
--
K
A
E
A
K
A
M
---
E
L
---
L
D
K
V
G
L
K
-
D
-
K
----
A
H
A
Y
P
D
-----------
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
-
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
-
M
-
G
F
A
R
-
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
-----------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
70.59
34%
-91
- C1 -
2Q0H
4
?
B:
[24-237]
---
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
L
E
-
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
-
K
D
T
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
--
N
--
I
T
L
----
A
P
MKV
R
K
W
P
----
R
--
E
--
K
A
E
A
K
A
M
---
E
L
---
L
D
K
V
G
L
K
-
D
-
K
----
A
H
A
Y
P
D
-----------
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
-
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
-
M
-
G
F
A
R
-
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
-----------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
70.51
34%
-88
- C1 -
3C41
3
?
J:
[3-216]
---
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
L
E
-
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
-
K
D
T
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
--
N
--
I
T
L
----
A
P
MKV
R
K
W
P
----
R
--
E
--
K
A
E
A
K
A
M
---
E
L
---
L
D
K
V
G
L
K
-
D
-
K
----
A
H
A
Y
P
D
-----------
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
-
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
-
M
-
G
F
A
R
-
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
-----------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
70.29
34%
-88
- C1 -
2Q0H
4
?
A:
[24-237]
---
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
L
E
-
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
-
K
D
T
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
--
N
--
I
T
L
----
A
P
M
K
V
R
K
W
P
----
R
--
E
--
K
A
E
A
K
A
M
---
E
L
---
L
D
K
V
G
L
K
-
D
-
K
----
A
H
A
Y
P
D
-----------
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
-
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
-
M
-
G
F
A
R
-
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
-----------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
70.28
34%
-85
- C1 -
2OLJ
3
?
B:
[24-237]
---
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
L
E
-
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
-
K
D
T
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
--
N
--
I
T
L
----
A
P
MKV
R
K
W
P
----
R
--
E
--
K
A
E
A
K
A
M
---
E
L
---
L
D
K
V
G
L
K
-
D
-
K
----
A
H
A
Y
P
D
-----------
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
-
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
-
M
-
G
F
A
R
-
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
-----------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
68.27
32%
-76
- C1 -
4MKI
4
ECFA2_CALS4
B:
[7-228]
----
I
K
V
E
N
V
S
F
I
Y
N
E
G
T
P
Y
A
T
V
A
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
N
G
I
D
I
T
D
-
K
K
V
S
L
K
D
I
R
-
K
Q
V
G
L
V
F
Q
Y
P
E
Y
Q
L
F
E
E
T
V
F
--
K
--
D
I
A
----
F
G
---
P
S
N
L
----
G
--
L
--
S
E
E
E
V
K
E
---
R
V
Y
E
A
M
E
I
V
G
I
S
K
E
-
L
----
A
D
K
S
P
F
-----------
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
K
I
K
E
I
H
D
K
Y
K
M
I
T
I
L
V
S
H
N
M
E
-
D
I
-
A
-
R
I
A
D
K
I
I
V
M
N
R
G
K
I
E
L
---------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
65.93
32%
-70
- C1 -
4MKI
4
ECFA2_CALS4
A:
[7-228]
----
I
K
V
E
N
V
S
F
I
Y
N
E
G
T
P
Y
A
T
V
A
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
N
G
I
D
I
T
D
-
K
K
V
S
L
K
D
I
R
-
K
Q
V
G
L
V
F
Q
Y
P
E
Y
Q
L
F
E
E
T
V
F
--
K
--
D
I
A
----
F
G
---
P
S
N
L
----
G
--
L
--
S
E
E
E
V
K
E
---
R
V
Y
E
A
M
E
I
V
G
I
S
K
E
-
L
----
A
D
K
S
P
F
-----------
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
K
I
K
E
I
H
D
K
Y
K
M
I
T
I
L
V
S
H
N
M
E
-
D
I
-
A
-
R
I
A
D
K
I
I
V
M
N
R
G
K
I
E
L
---------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
59.99
33%
-88
- C1 -
1VCI
1
?
A:
[13-209]
----
V
K
L
E
N
L
T
K
R
F
G
----
N
F
T
-
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
D
R
D
V
T
Y
L
P
P
K
D
------
R
N
I
S
M
V
F
Q
------
H
M
T
V
Y
E
--
N
I
A
F
P
L
---------
K
K
F
P
----
K
--
D
--
E
I
D
K
R
V
R
---
W
A
---
A
E
L
L
Q
I
E
-
E
-
L
----
L
N
R
Y
P
A
-----------
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
K
V
T
T
I
Y
V
T
H
D
-
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
110
PsiBlast_CBE
40.55
32%
-88
- C1 -
3J15
1
?
B:
[364-517]
------------------------------
E
I
R
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
T
E
G
K
V
---
E
W
D
L
T
V
A
Y
K
P
Q
Y
I
K
A
E
Y
E
G
--------------
T
V
-------
Y
E
L
----
L
S
---
K
I
D
S
----
S
--
K
--
L
N
S
N
F
Y
K
T
--
E
L
---
L
K
P
L
G
I
I
-
D
-
L
----
Y
D
R
N
V
E
-----------
D
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
K
T
A
L
V
V
E
H
D
---------------------------------------------------------------------------------------------------------------------------------------------------------
111
PsiBlast_CBE
36.91
32%
-86
- C1 -
3BK7
1
?
A:
[378-531]
------------------------------
E
I
R
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
T
E
G
K
V
---
E
W
D
L
T
V
A
Y
K
P
Q
Y
I
K
A
E
Y
E
G
--------------
T
V
-------
Y
E
L
----
L
S
---
K
I
D
S
----
S
--
K
--
L
N
S
N
F
Y
K
T
--
E
L
---
L
K
P
L
G
I
I
-
D
-
L
----
Y
D
R
N
V
E
-----------
D
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
K
T
A
L
V
V
E
H
D
---------------------------------------------------------------------------------------------------------------------------------------------------------