@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1109: (2016-03-22 )
MSSNELLLATEYLEKEKKIPRAVLIDAIEAALITAYKKNYDSARNVRVELNMDQGTFKVIARKDVVEEVFDDRDEVDLSTALVKNPAYEIGDIYEEDVTPKDFGRVGAQAAKQAVMQRLRDAEREILFEEFIDKEEDILTGIIDRVDHRYVYVNLGRIEAVLSEAERSPNEKYIPNERIKVYVNKVEQTTKGPQIYVSRSHPGLLKRLFEQEVPEIYDGTVIVKSVAREAGDRSKISVFSENNDIDAVGACVGAKGARVEAVVEELGGEKIDIVQWNEDPKVFVKNALSPSQVLEVIVDETNQSTVVVVPDYQLSLAIGKRGQNARLAAKLTGWKIDIKSETDAREAGIYPVVEAEKVTEEDIALEDADTTESTEEVNDVSVETNVEKESE
Atome Classification :
(20 SA)
.......--..10........20........30......-..--40........50....-----....60........70........80........90........100.......110........120.......130.......140......----.-----150....----.----..160.......----------------170.......180.......190.......200..---.....210..------.....220.......230.......240......-.250.......260....-----...270.......280......--.290....-...300..--.......310.......320..---....----.330.........340.......350--...-----.....360.......370.......380.......390--
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSSN
E
L
L
--
L
A
T
E
Y
L
E
K
E
KKI
P
R
A
V
L
I
D
A
I
E
A
A
L
I
T
A
Y
K
-KN--YDSA
R
N
V
R
V
E
L
NMDQG-----
T
F
K
V
I
A
R
K
D
V
V
E
E
V
FDDRDEV
D
L
S
T
A
L
VKNPA
Y
E
I
G
D
I
Y
EEDV
T
P
K
D
F
G
R
V
G
A
Q
A
A
-
K
Q
A
V
M
Q
R
L
R
D
A
E
R
E
I
L
F
E
E
F
ID
K
E
E
D
I
L
T
G
I
I
D
RVDH----
R
-----
Y
V
Y
V
N
L
G
----
R
----
I
E
A
V
L
S
E
A
ERSP----------------NEKYIPN
E
R
I
K
V
Y
V
N
K
V
E
QTTKG
P
Q
I
Y
V
SRSH
P
G
L
---
L
K
R
L
F
E
Q
E
V
P
------
E
IYD
G
T
V
I
V
K
S
V
A
R
EAGDRS
K
I
S
V
FSENND
I
D
A
V
-
G
A
C
VGAKG
A
R
V
E
A
V
V
E
E
L-----GG
E
K
I
D
I
V
QWNED
P
K
V
F
V
K
NAL--
S
P
S
Q
V
L
E
V
-
I
VDE--TN--Q
S
T
V
V
V
VPD
Y
Q
L
S
L
A
IGKRGQN---
A
R
L
A
----
A
K
--
L
T
G
W
K
I
D
IKSETDAREAG
I
Y
P
---VV
E
-----
A
EKVTEEDIALEDADTTESTEEVN
D
V
S
V
ETNVEKESE---
3
PsiBlast_PDB
93.38
38%
-89
- C6 -
4MTN
2
?
A:
[5-314]
--
G
N
E
V
L
--
R
I
V
D
S
I
H
R
D
K
S
I
D
K
E
I
V
F
E
G
V
E
Q
A
I
L
S
A
A
R
-
K
H
--
F
G
E
E
E
V
I
E
V
H
I
D
R
T
S
G
-----
Q
P
M
V
---
K
T
N
G
R
E
I
--
D
R
D
E
--------------
L
G
D
I
---------
L
G
R
I
S
A
Q
T
--
K
Q
V
M
I
Q
K
I
R
E
A
E
R
D
T
L
F
D
E
Y
A
Q
L
R
G
Q
I
V
S
G
T
V
T
R
N
E
G
----
S
-----
A
I
T
V
N
I
G
----
K
----
A
E
A
I
L
P
R
S
E
M
I
P
----------------
G
E
S
H
R
P
N
E
R
I
R
A
V
V
L
E
V
K
K
M
G
P
R
V
R
V
V
L
S
R
A
H
P
D
F
---
V
R
R
L
L
E
L
E
I
P
------
E
V
N
E
R
I
I
E
I
R
S
L
A
R
E
A
G
Y
R
T
K
V
A
V
S
C
A
D
S
N
I
D
P
V
-
G
A
C
V
G
V
R
G
A
R
I
R
N
V
G
E
E
L
-----
G
G
E
R
I
E
V
V
R
W
N
D
S
L
Q
V
L
V
P
N
A
M
--
Q
P
S
E
V
E
D
V
-
I
L
C
P
--
M
L
--
G
R
V
L
V
L
V
R
D
D
Q
L
S
L
A
I
G
K
R
G
Q
N
---
V
R
L
A
----
S
K
--
L
V
G
W
D
I
D
V
M
T
--------------------------------------------------------------
1
PsiBlast_PDB
90.74
43%
-71
- C6 -
1HH2
-
?
P:
[5-339]
-----
L
L
--
E
A
L
D
Q
L
E
E
E
K
G
I
S
K
E
E
V
I
P
I
L
E
K
A
L
V
S
A
Y
R
-
K
N
--
F
G
N
S
K
N
V
E
V
V
I
D
R
N
T
G
-----
N
I
K
V
Y
Q
L
L
E
V
V
E
E
V
E
D
P
A
T
Q
I
S
L
E
E
A
K
K
I
D
P
L
A
E
V
G
S
I
V
K
K
E
L
N
V
K
N
F
G
R
I
A
A
Q
T
A
-
K
Q
V
L
I
Q
R
I
R
E
L
E
K
E
K
Q
F
E
K
Y
S
E
L
K
G
T
V
T
T
A
E
V
I
R
V
M
G
----
E
-----
W
A
D
I
R
I
G
----
K
----
L
E
T
R
L
P
K
K
E
W
I
P
----------------
G
E
E
I
K
A
G
D
L
V
K
V
Y
I
I
D
V
V
K
T
T
K
G
P
K
I
L
V
S
R
R
V
P
E
F
---
V
I
G
L
M
K
L
E
I
P
------
E
V
E
N
G
I
V
E
I
K
A
I
A
R
E
P
G
V
R
T
K
V
A
V
A
S
N
D
P
N
V
D
P
I
-
G
A
C
I
G
E
G
G
S
R
I
A
A
I
L
K
E
L
-----
K
G
E
K
L
D
V
L
K
W
S
D
D
P
K
Q
L
I
A
N
A
L
--
A
P
A
T
V
I
E
V
E
I
L
D
K
--
E
N
--
K
A
A
R
V
L
V
P
P
T
Q
L
S
L
A
I
G
K
G
G
Q
N
---
A
R
L
A
----
A
K
--
L
T
G
W
K
I
D
I
K
---------------------------------------------------------------
17
Fugue
90.37
42%
-68
- C6 -
1HH2
-
?
P:
[1-344]
M
N
I
-
G
L
L
--
E
A
L
D
Q
L
E
E
E
K
G
I
S
K
E
E
V
I
P
I
L
E
K
A
L
V
S
A
Y
R
-
K
N
--
F
G
N
S
K
N
V
E
V
V
I
D
R
N
T
G
-----
N
I
K
V
Y
Q
L
L
E
V
V
E
E
V
E
D
P
A
T
Q
I
S
L
E
E
A
K
K
I
D
P
L
A
E
V
G
S
I
V
K
K
E
L
N
V
K
N
F
G
R
I
A
A
Q
T
A
-
K
Q
V
L
I
Q
R
I
R
E
L
E
K
E
K
Q
F
E
K
Y
S
E
L
K
G
T
V
T
T
A
E
V
I
R
V
M
G
----
E
-----
W
A
D
I
R
I
G
----
K
----
L
E
T
R
L
P
K
K
E
W
I
P
----------------
G
E
E
I
K
A
G
D
L
V
K
V
Y
I
I
D
V
V
K
T
T
K
G
P
K
I
L
V
S
R
R
V
P
E
F
---
V
I
G
L
M
K
L
E
I
P
------
E
V
E
N
G
I
V
E
I
K
A
I
A
R
E
P
G
V
R
T
K
V
A
V
A
S
N
D
P
N
V
D
P
I
-
G
A
C
I
G
E
G
G
S
R
I
A
A
I
L
K
E
L
-----
K
G
E
K
L
D
V
L
K
W
S
D
D
P
K
Q
L
I
A
N
A
L
--
A
P
A
T
V
I
E
V
E
I
L
D
K
--
E
N
--
K
A
A
R
V
L
V
P
P
T
Q
L
S
L
A
I
G
K
G
G
Q
N
---
A
R
L
A
----
A
K
--
L
T
G
W
K
I
D
I
K
P
I
M
N
L
----------------------------------------------------------
27
HHSearch
90.20
42%
-64
- C6 -
1HH2
-
?
P:
[1-342]
-
M
N
I
G
L
L
--
E
A
L
D
Q
L
E
E
E
K
G
I
S
K
E
E
V
I
P
I
L
E
K
A
L
V
S
A
Y
R
-
K
N
--
F
G
N
S
K
N
V
E
V
V
I
D
R
N
T
G
-----
N
I
K
V
Y
Q
L
L
E
V
V
E
E
V
E
D
P
A
T
Q
I
S
L
E
E
A
K
K
I
D
P
L
A
E
V
G
S
I
V
K
K
E
L
N
V
K
N
F
G
R
I
A
A
Q
T
A
-
K
Q
V
L
I
Q
R
I
R
E
L
E
K
E
K
Q
F
E
K
Y
S
E
L
K
G
T
V
T
T
A
E
V
I
R
V
M
G
----
E
-----
W
A
D
I
R
I
G
----
K
----
L
E
T
R
L
P
K
K
E
W
I
P
----------------
G
E
E
I
K
A
G
D
L
V
K
V
Y
I
I
D
V
V
K
T
T
K
G
P
K
I
L
V
S
R
R
V
P
E
F
---
V
I
G
L
M
K
L
E
I
P
------
E
V
E
N
G
I
V
E
I
K
A
I
A
R
E
P
G
V
R
T
K
V
A
V
A
S
N
D
P
N
V
D
P
I
-
G
A
C
I
G
E
G
G
S
R
I
A
A
I
L
K
E
L
-----
K
G
E
K
L
D
V
L
K
W
S
D
D
P
K
Q
L
I
A
N
A
L
--
A
P
A
T
V
I
E
V
-
E
I
L
D
K-
E
N
--
K
A
A
R
V
L
V
P
P
T
Q
L
S
L
A
I
G
K
G
G
Q
N
---
A
R
L
A
----
A
K
--
L
T
G
W
K
I
D
I
K
P
I
M
------------------------------------------------------------
29
HHSearch
80.20
48%
-74
- C6 -
2ASB
1
NUSA_MYCTU
A:
[4-229]
----------------------------------------------------------------------------------------------------------------------------------------------
S
T
R
E
G
E
I
V
A
G
V
I
Q
R
D
S
R
A
N
A
R
G
-----
L
V
V
V
R
I
G
T
E
T
K
A
----
S
E
G
V
I
P
A
A
E
Q
V
P
----------------
G
E
S
Y
E
H
G
N
R
L
R
C
Y
V
V
G
V
T
R
G
A
R
E
P
L
I
T
L
S
R
T
H
P
N
L
---
V
R
K
L
F
S
L
E
V
P
------
E
I
A
D
G
S
V
E
I
V
A
V
A
R
E
A
G
H
R
S
K
I
A
V
R
S
N
V
A
G
L
N
A
K
-
G
A
C
I
G
P
M
G
Q
R
V
R
N
V
M
S
E
L
-----
S
G
E
K
I
D
I
I
D
Y
D
D
D
P
A
R
F
V
A
N
A
L
--
S
P
A
K
V
V
S
V
-
S
V
I
D
Q-
T
A
--
R
A
A
R
V
V
V
P
D
F
Q
L
S
L
A
I
G
K
E
G
Q
N
---
A
R
L
A
----
A
R
--
L
T
G
W
R
I
D
I
R
G
D
A
P
P
P
P
P
G
------------------------------------------------------
16
PsiBlast_CBE
80.08
49%
-76
- C6 -
2ATW
1
NUSA_MYCTU
C:
[2-223]
--------------------------------------------------------------------------------------------------------------------------------------------
E
F
S
T
R
E
G
E
I
V
A
G
V
I
Q
R
-
D
S
----
R
ANARG
L
V
V
V
R
I
G
----
T
ETKA
S
E
G
V
I
P
A
A
E
Q
V
P
----------------
G
E
S
Y
E
H
G
N
R
L
R
C
Y
V
V
G
V
T
R
G
A
R
E
P
L
I
T
L
S
R
T
H
P
N
L
---
V
R
K
L
F
S
L
E
V
P
------
E
I
A
D
G
S
V
E
I
V
A
V
A
R
E
A
G
H
R
S
K
I
A
V
R
S
N
V
A
G
L
N
A
K
-
G
A
C
I
G
P
M
G
Q
R
V
R
N
V
M
S
E
L
-----
S
G
E
K
I
D
I
I
D
Y
D
D
D
P
A
R
F
V
A
N
A
L
--
S
P
A
K
V
V
S
V
S
V
I
D
Q
--
T
A
--
R
A
A
R
V
V
V
P
D
F
Q
L
S
L
A
I
G
K
E
G
Q
N
---
A
R
L
A
----
A
R
--
L
T
G
W
R
I
D
I
R
G
D
A
------------------------------------------------------------
4
PsiBlast_PDB
79.63
49%
-73
- C6 -
2ASB
1
NUSA_MYCTU
A:
[4-223]
----------------------------------------------------------------------------------------------------------------------------------------------
S
T
R
E
G
E
I
V
A
G
V
I
Q
R
-
D
S
----
R
A
N
A
R
G
L
V
V
V
R
I
G
----
T
E
T
K
A
S
E
G
V
I
P
A
A
E
Q
V
P
----------------
G
E
S
Y
E
H
G
N
R
L
R
C
Y
V
V
G
V
T
R
G
A
R
E
P
L
I
T
L
S
R
T
H
P
N
L
---
V
R
K
L
F
S
L
E
V
P
------
E
I
A
D
G
S
V
E
I
V
A
V
A
R
E
A
G
H
R
S
K
I
A
V
R
S
N
V
A
G
L
N
A
K
-
G
A
C
I
G
P
M
G
Q
R
V
R
N
V
M
S
E
L
-----
S
G
E
K
I
D
I
I
D
Y
D
D
D
P
A
R
F
V
A
N
A
L
--
S
P
A
K
V
V
S
V
S
V
I
D
Q
--
T
A
--
R
A
A
R
V
V
V
P
D
F
Q
L
S
L
A
I
G
K
E
G
Q
N
---
A
R
L
A
----
A
R
--
L
T
G
W
R
I
D
I
R
G
D
A
------------------------------------------------------------
5
PsiBlast_PDB
78.68
49%
-73
- C6 -
2ATW
1
NUSA_MYCTU
A:
[3-223]
---------------------------------------------------------------------------------------------------------------------------------------------
F
S
T
R
E
G
E
I
V
A
G
V
I
Q
R
-
D
S
----
R
A
N
A
R
G
L
V
V
V
R
I
G
----
T
ET
K
A
S
E
G
V
I
P
A
A
E
Q
V
P
----------------
G
E
S
Y
E
H
G
N
R
L
R
C
Y
V
V
G
V
T
R
G
A
R
E
P
L
I
T
L
S
R
T
H
P
N
L
---
V
R
K
L
F
S
L
E
V
P
------
E
I
A
D
G
S
V
E
I
V
A
V
A
R
E
A
G
H
R
S
K
I
A
V
R
S
N
V
A
G
L
N
A
K
-
G
A
C
I
G
P
M
G
Q
R
V
R
N
V
M
S
E
L
-----
S
G
E
K
I
D
I
I
D
Y
D
D
D
P
A
R
F
V
A
N
A
L
--
S
P
A
K
V
V
S
V
S
V
I
D
Q
--
T
A
--
R
A
A
R
V
V
V
P
D
F
Q
L
S
L
A
I
G
K
E
G
Q
N
---
A
R
L
A
----
A
R
--
L
T
G
W
R
I
D
I
R
G
D
A
------------------------------------------------------------
2
PsiBlast_PDB
63.29
43%
-4
- C6 -
1L2F
-
?
A:
[5-339]
-----
L
L
--
E
A
L
D
Q
L
E
E
E
K
G
I
S
K
E
E
V
I
P
I
L
E
K
A
L
V
S
A
Y
R
-
K
N
--
F
G
N
S
K
N
V
E
V
V
I
D
R
N
T
G
-----
N
I
K
V
Y
Q
L
L
E
V
V
E
E
V
E
D
P
A
T
Q
I
S
L
E
E
A
K
K
I
D
P
L
A
E
V
G
S
I
V
K
K
E
L
N
V
K
N
F
G
R
I
A
A
Q
T
A
-
K
Q
V
L
I
Q
R
I
R
E
L
E
K
E
K
Q
F
E
K
Y
S
E
L
K
G
T
V
T
T
A
E
V
I
R
V
M
G
----
E
-----
W
A
D
I
R
I
G
----
K
----
L
E
T
R
L
P
K
K
E
W
I
P
----------------
G
E
E
I
K
A
G
D
L
V
K
V
Y
I
I
D
V
V
K
T
T
K
G
P
K
I
L
V
S
R
R
V
P
E
F
---
V
I
G
L
M
K
L
E
I
P
------
E
V
E
N
G
I
V
E
I
K
A
I
A
R
E
P
G
V
R
T
K
V
A
V
A
S
N
D
P
N
V
D
P
I
-
G
A
C
I
G
E
G
G
S
R
I
A
A
I
L
K
E
L
-----
K
G
E
K
L
D
V
L
K
W
S
D
D
P
K
Q
L
I
A
N
A
L
--
A
P
A
T
V
I
E
V
E
I
L
D
K
--
E
N
--
K
A
A
R
V
L
V
P
P
T
Q
L
S
L
A
I
G
K
G
G
Q
N
---
A
R
L
A
----
A
K
--
L
T
G
W
K
I
D
I
K
---------------------------------------------------------------
6
PsiBlast_PDB
48.13
35%
-38
- C6 -
2KWP
-
NUSA_ECOLI
A:
[2-126]
--
N
K
E
I
L
--
A
V
V
E
A
V
S
N
E
K
A
L
P
R
E
K
I
F
E
A
L
E
S
A
L
A
T
A
T
K
-
K
K
--
Y
E
Q
E
I
D
V
R
V
Q
I
D
R
K
S
G
-----
D
F
D
T
F
R
R
W
L
V
V
D
E
V
T
Q
P
T
K
E
I
T
L
E
A
A
R
Y
E
D
E
S
L
N
L
G
D
Y
V
E
D
Q
I
E
S
V
T
F
D
R
I
T
T
Q
T
A
-
K
Q
V
I
V
Q
K
V
R
E
A
E
R
A
M
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
46.85
34%
-37
- C6 -
2KWP
-
NUSA_ECOLI
A:
[1-128]
-
M
N
K
E
I
L
--
A
V
V
E
A
V
S
N
E
K
A
L
P
R
E
K
I
F
E
A
L
E
S
A
L
A
T
A
T
K
-
K
K
--
Y
E
Q
E
I
D
V
R
V
Q
I
D
R
K
S
G
-----
D
F
D
T
F
R
R
W
L
V
V
D
E
V
T
Q
P
T
K
E
I
T
L
E
A
A
R
Y
E
D
E
S
L
N
L
G
D
Y
V
E
D
Q
I
E
S
V
T
F
D
R
I
T
T
Q
T
A
-
K
Q
V
I
V
Q
K
V
R
E
A
E
R
A
M
L
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
45.63
19%
-77
- C6 -
2A19
-
IF2A_YEAST
A:
[7-89]
-----------------------------------------------------------------------------------------------------------------------------------------
F
Y
E
N
K
Y
P
E
I
D
D
I
V
M
V
N
V
Q
Q
I
A
E
----
M
-----
G
A
Y
V
K
L
L
EYD-
N
----
I
E
G
M
I
L
L
S
----S
I
--------------
Q
K
L
I
R
V
G
K
N
D
V
A
V
V
L
R
V
D
K
E
--
K
G
Y
I
D
L
S
K
R
R
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
38.78
31%
-34
- C6 -
2CY1
-
?
A:
[52-137]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
G
G
R
L
I
K
L
L
R
E
A
-----
L
G
K
N
I
E
V
V
E
Y
S
S
D
L
E
R
I
V
K
N
L
F
--
P
G
V
K
I
E
S
I
-
N
V
R
E
--
R
N
G
V
K
Q
V
V
I
K
V
S
E
D
D
K
G
A
A
I
G
K
G
G
K
N
V
K
R
A
R
L
V
L
---
S
K
--
L
F
G
---------------------------------------------------------------------
33
HHSearch
37.24
13%
-45
- C6 -
2B8K
-
RPB7_YEAST
G:
[79-171]
---------------------------------------------------------------------------------------------------------------------------------------------
F
K
P
F
K
G
E
V
V
D
G
T
V
V
S
C
S
Q
----
H
-----
G
F
E
V
Q
V
G
----
P
----
M
K
V
F
V
T
K
H
L
M
P
Q
D
L
T
F
N
AGSNP
P
S
Y
Q
S
S
E
D
V
I
T
I
K
S
R
I
R
V
K
I
E
G
C
I
S
Q
V
S
S
I
H
A
I
G
S
I
K
E
D
Y
L
GAI----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
37.06
26%
-36
- C6 -
2CXC
-
?
A:
[21-139]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
G
V
T
A
Y
R
C
I
V
D
E
E
N
N
R
L
I
F
L
V
S
E
G
-----
E
A
-
G
R
A
I
G
R
G
G
R
L
I
K
L
L
R
E
A
------
L
G
K
N
I
E
V
V
E
Y
S
S
D
L
E
R
I
V
K
N
L
F
--
P
G
V
K
I
E
S
I
-
N
V
R
E
R
N
G
V
--
K
Q
V
V
I
K
V
S
E
D
D
K
G
A
A
I
G
K
G
G
K
N
---
V
K
R
A
R
L
V
L
S
K
--
L
F
G
V
E
-------------------------------------------------------------------
26
Fugue
36.93
16%
-10
- C5 -
3LD1
-
R1A_IBVM
A:
[5-363]
-
L
R
D
V
I
L
--
V
S
-------
K
D
I
P
E
Q
L
C
D
A
L
F
---
F
Y
T
S
H
N
P
K
D
--
Y
A
D
A
F
A
V
R
Q
K
F
D
R
N
L
Q
T
G
K
Q
F
K
F
E
T
V
C
G
L
F
L
L
K
G
V
D
K
I
T
P
G
V
P
A
K
V
L
K
A
T
S
K
L
A
D
L
E
D
I
F
G
V
S
P
F
A
R
K
Y
R
E
L
L
K
T
A
C
-
Q
W
S
L
T
V
E
T
L
D
A
R
A
L
T
L
D
E
I
F
-
D
P
T
E
I
L
W
L
Q
V
A
A
K
--------------
I
Q
V
S
A
M
----
A
----
M
R
R
L
V
G
E
V
T
A
K
V
----------------
M
D
A
L
--
G
S
N
M
S
A
L
F
Q
I
F
K
Q
Q
------------------
I
V
R
I
F
Q
A
A
L
A
IFENVS
E
L
P
Q
R
I
A
A
L
K
M
A
F
A
K
C
A
K
S
I
T
V
V
V
M
E
R
T
L
V
V
R
E
F
A
G
T
C
L
A
S
I
N
G
A
V
A
K
F
F
E
E
L
P
N
G
F
M
G
A
K
I
F
T
T
F
A
F
F
R
E
A
A
V
K
I
V
D
N
I
PN
A
P
R
G
T
K
G
F
-
E
V
V
G
--
N
A
--
K
G
T
Q
V
V
V
R
G
M
R
N
D
L
T
L
L
D
--
Q
K
---
A
E
I
P
----
V
E
--
S
E
G
W
S
A
I
L
G
G
----
H
L
C
Y
V
F
K
S
GD
R
F
Y
-----
A
A
P
L
S
G
-
N
F
A
L
H
D
V
H
C
C
E
R
V
V
C
L
-----------------
20
Fugue
35.92
17%
-13
- C3 -
4MT7
-
ARHG9_RAT
A:
[96-432]
Q
N
R
D
Q
M
R
A
N
V
I
N
E
I
M
S
T
E
R
H
Y
I
K
H
-
L
K
D
I
C
E
G
Y
L
K
Q
C
R
K
-
R
R
DM
F
S
D
E
Q
L
K
V
I
F
G
N
I
E
D
I
-----
Y
R
F
Q
M
G
F
V
R
D
L
E
K
Q
Y
N
N
D
D
----------
P
H
L
S
E
I
G
P
C
F
L
E
H
--
Q
D
G
F
W
I
Y
S
E
Y
C
N
N
H
L
D
A
C
M
E
L
S
K
L
M
K
D
S
R
Y
Q
H
F
F
E
A
C
R
L
L
-
Q
Q
M
I
D
I
------------------------
A
----
I
D
G
F
L
--------------------------
L
T
P
V
Q
K
I
C
K
Y
P
L
Q
L
A
E
L
L
K
----
Y
T
A
Q
D
H
S
D
-----
Y
R
Y
V
A
A
A
L
A
------
V
M
R
N
V
T
Q
Q
I
N
E
R
K
R
R
L
E
N
I
D
K
I
A
Q
W
Q
A
S
---------
V
L
D
W
E
G
D
D
I
L
D
R
S
S
E
-------
L
I
Y
T
G
E
M
A
W
I
Y
Q
P
Y
---------------------
G
--
R
N
--
Q
Q
R
V
F
F
L
F
D
H
Q
M
V
L
C
K
K
D
L
I
R
R
---
D
I
L
Y
----
Y
K
GR
I
D
M
D
K
Y
E
V
I
D
I
E
D
G
R
D
D
D
F
N
V
---
S
M
K
N
A
F
K
L
H
N
K
E
T
E
E
V
H
L
F
F
A
K
K
L
E
E
K
I
R
W
L
R
A
F
R
E
E
R
K
M
V
Q
E
D
E
K
I
G
7
PsiBlast_PDB
35.75
31%
-21
- C6 -
2CXC
-
?
A:
[52-137]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
G
G
R
L
I
K
L
L
R
E
A
-----
L
G
K
N
I
E
V
V
E
Y
S
S
D
L
E
R
I
V
K
N
L
F
--
P
G
V
K
I
E
S
I
-
N
V
R
E
--
R
N
G
V
K
Q
V
V
I
K
V
S
E
D
D
K
G
A
A
I
G
K
G
G
K
N
V
K
R
A
R
L
V
L
---
S
K
--
L
F
G
---------------------------------------------------------------------
39
HHSearch
35.59
8%
-35
- C6 -
3H0G
-
RPB7_SCHPO
G:
[80-168]
---------------------------------------------------------------------------------------------------------------------------------------------
W
R
P
F
R
G
E
V
V
D
A
I
V
T
T
V
N
K
----
M
-----
G
F
F
A
N
I
G
----
P
----
L
N
V
F
V
S
S
H
L
V
P
P
DMKFDPTAN
P
P
N
Y
S
G
E
D
Q
V
I
E
K
G
S
N
V
R
L
K
I
V
G
T
R
T
D
A
T
E
I
F
A
I
A
T
M
K
E
D
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
35.42
11%
-48
* C6 *
1Y14
-
RPB7_YEAST
B:
[78-166]
--------------------------------------------------------------------------------------------------------------------------------------------
V
F
K
P
F
K
G
E
V
V
D
G
T
V
V
S
C
S
Q
----
H
-----
G
F
E
V
Q
V
G
----
P
----
M
K
V
F
V
T
K
H
L
M
P
Q
D
L
T
F
N
AS
Y
Q
S
S-----
E
D
V
I
T
I
K
S
R
I
R
V
K
I
E
G
C
I
S
Q
V
S
S
I
H
A
I
G
S
I
K
E
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------