@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1246: (2016-03-23 )
MTKRKLRNNWIIVTTMITFVTIFLFCLIIIFFLKDTLHNSELDDAERSSSDINNLFHSKPVKDISALDLNASLGNFQEIIIYDEHNNKLFETSNDNTVRVEPGYEHRYFDRVIKKRYKGIEYLIIKEPITTQDFKGYSLLIHSLENYDNIVKSLYIIALAFGVIATIITATISYVFSTQITKPLVSLSNKMIEIRRDGFQNKLQLNTNYEEIDNLANTFNEMMSQIEESFNQQRQFVEDASHELRTPLQIIQGHLNLIQRWGKKDPAVLEESLNISIEEMNRIIKLVEELLELTKGDVNDISSEAQTVHINDEIRSRIHSLKQLHPDYQFDTDLTSKNLEIKMKPHQFEQLFLIFIDNAIKYDVKNKKIKVKTRLKNKQKIIEITDHGIGIPEEDQDFIFDRFYRVDKSRSRSQGGNGLGLSIAQKIIQLNGGSIKIKSEINKGTTFKIIF
Atome Classification :
(22 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.....------..230.......240.......250......-.260..----.....270--.---.......280..-.....290---........-.300.....-------..310....-------------...320-.-----....--..--.-----.----330.-----.--.-....340......---------.350.......360---....-------.---..370...--....380-........390.......400......------.410.......420.......-430.......440.......450
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTKRKLRN
N
W
I
I
V
T
T
M
I
T
F
V
T
I
F
L
F
C
L
I
I
I
F
F
L
K
D
TLHNSELDDAERSS
S
D
I
N
N
L
FHSKPVKD
I
S
A
L
DLNASLGN
F
Q
E
I
I
I
Y
DEHNN
K
L
F
ETSND
N
T
V
R
VEPGYE
H
R
Y
F
D
R
V
I
K
K
R
YKGI
E
Y
L
I
I
KEPITTQDFK
G
Y
S
L
L
I
H
S
L
E
N
Y
D
N
I
V
K
S
L
Y
I
I
A
L
A
F
G
V
I
A
T
I
I
T
A
T
I
S
Y
V
F
STQI
T
K
P
L
V
S
L
S
N
K
M
I
E
I
R
RDGFQ
N
K
L
Q
LNT
N
Y
E
E
I
D
N
L
A
N
T
F
N
E
M
M
S
Q
I
E
------
E
S
F
N
Q
Q
R
Q
F
V
E
D
A
S
H
E
L
R
T
P
L
Q
I
I
Q
G
H
L
N
L
I
-
Q
R
WGKK----
D
P
A
V
L
E
E
---S---LNI
S
I
E
E
M
N
R
I
I
-
K
L
V
E
E
L
-----
L
E
LTKG
D
V
-
N
DISSEA
Q
T
-------
V
H
I
N
D
E
I
R
S
-------------
R
I
H
S
---
L
-----
K
Q
LH--PD--Y-----Q----FDTD-----L--T-SK
N
L
E
I
K
MKP
H
Q
F
---------
E
Q
L
F
L
I
F
IDN
A
I
K
Y---DVKN-------
K
---
K
I
K
V
K
T
RL--KNK
Q
K
I
--
I
E
ITDHGIGIPEE
D
Q
D
F
I
F
D
R
F
Y
R
VDK------SRSRSQGGNGL
G
L
S
I
A
Q
K
I
I
Q-LNG
G
S
I
K
I
K
S
EINKG
T
T
F
K
I
IF-
2
PsiBlast_PDB
82.05
35%
-67
- C3 -
4U7O
1
?
A:
[33-258]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
D
R
K
Q
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
-
S
D
G
A
W
K
----
D
P
E
V
A
P
G
---
F
---
L
K
V
T
Q
E
E
T
D
R
M
I
-
R
M
I
N
E
L
-----
L
S
L
S
R
M
D
S
-
G
T
T
R
V
D
M
E
L
-------
V
N
I
N
E
M
F
N
Y
-------------
V
L
D
R
---
F
D
M
I
L
K
K
D
D
N
--
P
A
K
Y
Y
-----
T
----
I
K
R
E
-----
F
--
T
-
K
R
D
L
W
V
E
I
D
T
D
K
F
---------
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
---
S
P
D
G
-------
G
---
V
V
T
C
R
L
L
E
--
T
H
N
Q
V
I
--
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
-----------
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
-
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
---
21
PsiBlast_CBE
81.67
35%
-53
- C3 -
4U7O
1
?
B:
[37-258]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
-
S
D
G
A
W
K
----
D
P
E
V
A
P
G
---
F
---
L
K
V
T
Q
E
E
T
D
R
M
I
-
R
M
I
N
E
L
-----
L
S
L
S
-------
T
R
V
D
M
E
L
-------
V
N
I
N
E
M
F
N
Y
-------------
V
L
D
R
---
F
D
M
I
L
K
K
D
D
N
--
P
A
KY
Y
-----
T
----
I
K
R
E
-----
F
--
T
-
K
R
D
L
W
V
E
I
D
T
D
K
F
---------
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
---
S
P
D
G
-------
G
---
V
V
T
C
R
L
L
E
--
T
H
N
Q
V
I
--
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
------
A
R
---
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
-
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
---
1
PsiBlast_PDB
80.45
35%
-60
- C3 -
4U7N
-
?
A:
[39-258]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
-
S
D
G
A
W
K
----
D
P
E
V
A
P
G
---
F
---
L
K
V
T
Q
E
E
T
D
R
M
I
-
R
M
I
N
E
L
-----
L
S
L
S
R
M
D
S
-
G
T
T
R
V
D
M
E
L
-------
V
N
I
N
E
M
F
N
Y
-------------
V
L
D
R
---
F
D
M
I
L
K
K
D
D
N
----Y-
Y
-----
T
----
I
K
R
E
-----
F
--
T
-
K
R
D
L
W
V
E
I
D
T
D
K
F
---------
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
---
S
P
D
G
-------
G
---
V
V
T
C
R
L
L
E
--
T
H
N
Q
V
I
--
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
-----------------
T
G
L
G
L
A
I
S
K
E
V
V
Q
-
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
---
22
PsiBlast_CBE
79.90
32%
-55
- C3 -
4JAV
6
?
B:
[22-241]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
G
E
L
----
D
L
S
T
L
K
E
---
F
---
L
E
V
I
I
D
Q
S
N
H
L
E
-
N
L
L
N
E
L
-----
L
D
F
S
R
L
E
R
-
K
S
L
Q
I
N
R
E
K
-------
V
D
L
C
D
L
V
E
S
-------------
A
V
N
A
---
I
-----
K
E
F
A
--
S
S
--
H
-----
N
V
N
V
L
F
E
S
N
-----
V
--
P
-
C
P
-
V
E
A
Y
I
D
P
T
R
I
---------
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
SKK
D
A
P
D
-------
K
---
Y
V
K
V
I
L
D
E
--
K
D
G
G
V
L
--
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
------
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
-----
7
PsiBlast_PDB
79.09
32%
-57
- C3 -
4JAV
6
?
A:
[22-241]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
G
E
L
----
D
L
S
T
L
K
E
---
F
---
L
E
V
I
I
D
Q
S
N
H
L
E
-
N
L
L
N
E
L
-----
L
D
F
S
R
L
E
R
-
K
S
L
Q
I
N
R
E
K
-------
V
D
L
C
D
L
V
E
S
-------------
A
V
N
A
---
I
-----
K
E
F
A
--
S
S
--
H
-----
N
V
N
V
L
F
E
S
N
-----
V
--
P
-
C
P
-
V
E
A
Y
I
D
P
T
R
I
---------
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
SKK
D
A
P
D
-------
K
---
Y
V
K
V
I
L
D
E
--
K
D
G
G
V
L
--
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
------
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
-----
23
PsiBlast_CBE
78.91
32%
-49
- C3 -
3DGE
2
?
B:
[22-241]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
G
E
L
----
D
L
S
T
L
K
E
---
F
---
L
E
V
I
I
D
Q
S
N
H
L
E
-
N
L
L
N
E
L
-----
L
D
F
S
R
L
E
R
-
K
S
L
Q
I
N
R
E
K
-------
V
D
L
C
D
L
V
E
S
-------------
A
V
N
A
---
I
-----
K
E
F
A
--
S
S
--
H
-----
N
VNVL
F
E
S
N
-----
V
--
P
-
C
P
-
V
E
A
Y
I
D
P
T
R
I
---------
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
SKK
D
A
P
D
-------
K
---
Y
V
K
V
I
L
D
E
--
K
D
G
G
V
L
--
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
------
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
-----
4
PsiBlast_PDB
78.81
33%
-55
- C3 -
4JAS
2
?
A:
[22-241]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
V
I
K
G
Y
A
E
M
I
Y
N
S
L
G
E
L
----
D
L
S
T
L
K
E
---
F
---
L
E
T
I
I
E
Q
S
N
H
L
E
-
N
L
L
N
E
L
-----
L
D
F
S
R
L
E
R
-
K
S
L
Q
I
N
R
E
K
-------
V
D
L
C
D
L
V
E
S
-------------
A
V
N
A
---
I
-----
K
E
F
A
--
S
S
--
H
-----
N
V
N
V
L
F
E
S
N
-----
V
--
P
-
C
P
-
V
E
A
Y
I
D
P
T
R
I
---------
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
SKK
D
A
P
D
-------
K
---
Y
V
K
V
I
L
D
E
--
K
D
G
G
V
L
--
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
------
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
-----
5
PsiBlast_PDB
78.34
33%
-64
- C3 -
4JAU
1
?
A:
[22-241]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
V
I
K
G
Y
A
E
M
I
Y
N
S
L
G
E
L
----
D
L
S
T
L
K
E
---
F
---
L
E
T
I
I
E
Q
S
N
H
L
E
-
N
L
L
N
E
L
-----
L
D
F
S
R
L
E
R
-
K
S
L
Q
I
N
R
E
K
-------
V
D
L
C
D
L
V
E
S
-------------
A
V
N
A
---
I
-----
K
E
F
A
--
S
S
--
H
-----
N
V
N
V
L
F
E
S
N
-----
V
--
P
-
C
P
-
V
E
A
Y
I
D
P
T
R
I
---------
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
SKK
D
A
P
D
-------
K
---
Y
V
K
V
I
L
D
E
--
K
D
G
G
V
L
--
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
---------------
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
-----
6
PsiBlast_PDB
77.55
32%
-45
- C3 -
3DGE
3
?
A:
[22-241]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
G
E
L
----
D
L
S
T
L
K
E
---
F
---
L
E
V
I
I
D
Q
S
N
H
L
E
-
N
L
L
N
E
L
-----
L
D
F
S
R
L
E
R
-
K
S
L
Q
I
N
R
E
K
-------
V
D
L
C
D
L
V
E
S
-------------
A
V
N
A
---
I
-----
K
E
F
A
--
S
S
--
H
-----
N
V
N
V
L
F
E
S
N
-----
V
--
P
-
C
P
-
V
E
A
Y
I
D
P
T
R
I
---------
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
SKK
D
A
P
D
-------
K
---
Y
V
K
V
I
L
D
E
--
K
D
G
G
V
L
--
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
------
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
-----
29
HHSearch
76.76
30%
-65
- C3 -
2C2A
2
?
A:
[15-245]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
D
R
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
-
Y
N
S
L
G
E
L---
D
L
S
T
L
K
E
---
F
---
L
E
V
I
I
D
Q
S
N
H
L
E
-
N
L
L
N
E
L
-----
L
D
F
S
R
L
E
R
-
K
S
L
Q
I
N
R
E
K
-------
V
D
L
C
D
L
V
E
S
-------------
A
V
N
A
---
I
-----
K
E
F
A
--
S
S
--
H
-----
N
----
V
N
V
L
-----
F
E
S
N
V
P
C
P
V
E
A
Y
I
D
P
T
R
I
---------
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
---
S
K
K
D
-------
A
P
D
K
Y
V
K
V
I
L
D
E
--
K
D
G
G
V
L
--
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
---------------
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
-
51
Fugue
76.51
22%
-33
- C3 -
4I5S
-
?
A:
[37-432]
--------------------------------------------------------
N
N
N
Q
V
K
Q
L
N
A
K
V
R
S
L
I
T
G
H
Y
T
D
K
L
K
V
E
D
N
S
D
L
S
E
L
V
N
N
V
N
D
L
S
E
V
F
R
L
T
H
E
N
L
A
Q
E
K
N
R
L
T
S
I
L
S
Y
M
--
T
D
G
V
L
A
T
D
R
S
G
K
I
T
V
I
N
--
D
M
A
Q
K
Q
L
N
V
T
R
E
Q
A
L
E
C
N
I
L
D
I
L
D
D
-------
D
S
Y
T
Y
N
D
L
I
T
K
T
P
E
I
V
L
T
R
R
D
E
Y
D
E
F
I
T
L
R
I
R
F
A
L
N
R
R
E
S
G
F
I
S
G
L
I
A
V
L
H
DA
T
E
Q
E
K
E
E
R
E
R
R
L
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
V
K
S
Y
L
E
A
L
-
D
D
-
G
A
L
----
T
E
S
V
A
P
S
---
F
---
I
K
V
S
L
D
E
T
N
R
M
M
-
R
M
I
T
D
L
-----
L
S
L
S
R
S
H
L
-
D
V
-----
E
L
-------
T
N
F
T
A
F
M
N
Y
-------------
I
L
D
R
---
F
-----
D
Q
I
Q
SQ
Q
S
--
T
-----
E
----
I
I
R
D
-----
Y
--
P
-
D
K
S
V
W
I
E
I
D
T
D
K
M
---------
T
Q
V
I
D
N
I
L
N
N
A
I
K
Y
---
S
P
D
G
-------
G
---
K
V
T
I
T
M
Q
T
--
T
D
T
Q
L
I
--
L
S
I
S
D
Q
G
L
G
I
P
K
K
D
L
P
L
I
F
D
R
F
Y
R
V
D
K
------
A
R
-------
G
L
G
L
A
I
A
K
E
I
V
K
-
Q
H
K
G
F
I
W
A
N
S
E
E
G
E
G
S
T
F
T
I
V
L
P
8
PsiBlast_PDB
75.74
32%
-61
- C3 -
2C2A
2
?
A:
[22-241]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
G
E
L
----
D
L
S
T
L
K
E
---
F
---
L
E
V
I
I
D
Q
S
N
H
L
E
-
N
L
L
N
E
L
-----
L
D
F
S
R
L
E
R
-
K
S
L
Q
I
N
R
E
K
-------
V
D
L
C
D
L
V
E
S
-------------
A
V
N
A
---
I
-----
K
E
F
A
--
S
S
--
H
-----
N
V
N
V
L
F
E
S
N
-----
V
--
P
-
C
P
-
V
E
A
Y
I
D
P
T
R
I
---------
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
SKK
D
A
P
D
-------
K
---
Y
V
K
V
I
L
D
E
--
K
D
G
G
V
L
--
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
---------------
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
-----
3
PsiBlast_PDB
69.20
34%
-45
- C3 -
4I5S
-
?
A:
[211-431]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
V
K
S
Y
L
E
A
L
-
D
D
-
G
A
L
----
T
E
S
V
A
P
S
---
F
---
I
K
V
S
L
D
E
T
N
R
M
M
-
R
M
I
T
D
L
-----
L
S
L
S
R
--------------------
S
H
L
D
V
E
L
T
N
F
T
A
F
M
N
Y
I
L
D
R
F
D
Q
I
Q
S
---
Q
-----
Q
S
T
-------------
E
----
I
I
R
D
-----
Y
--
P
-
D
K
S
V
W
I
E
I
D
T
D
K
M
---------
T
Q
V
I
D
N
I
L
N
N
A
I
K
Y
---
S
P
D
G
-------
G
---
K
V
T
I
T
M
Q
T
--
T
D
T
Q
L
I
--
L
S
I
S
D
Q
G
L
G
I
P
K
K
D
L
P
L
I
F
D
R
F
Y
R
V
D
K
------
A
R
-------
G
L
G
L
A
I
A
K
E
I
V
K
-
Q
H
K
G
F
I
W
A
N
S
E
E
G
E
G
S
T
F
T
I
V
L
-
19
PsiBlast_PDB
67.20
25%
-47
- C3 -
3D36
4
?
A:
[22-220]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
I
R
N
P
L
T
A
A
R
G
F
I
Q
L
I
-
E
----
E
----
Q
P
L
A
A
D
K
---
R
R
Q
Y
A
R
I
A
I
E
E
L
D
R
A
E
-
A
I
I
T
D
Y
-----
L
T
F
A
K
-----
P
A
P
E
T
P
E
K
-------
L
N
V
K
L
E
I
E
R
-------------
V
I
D
I
---
L
-----
R
P
L
A
--
N
M
--
S
-----
C
----
V
D
I
Q
-----
A
--
T
-
L
A
P
F
S
V
I
G
E
R
E
K
F
---------
R
Q
C
L
L
N
V
M
K
N
A
I
E
A
---
M
P
N
G
-------
G
---
T
L
Q
V
Y
V
S
I
--
D
N
G
R
V
L
--
I
R
I
A
D
T
G
V
G
M
T
K
E
Q
L
E
R
L
G
E
P
Y
F
T
-----------
T
K
G
V
K
G
T
G
L
G
M
M
V
V
Y
R
I
I
E
-
S
M
N
G
T
I
R
I
E
S
E
I
H
K
G
T
T
V
S
I
---
14
PsiBlast_PDB
66.46
24%
-34
- C3 -
4BIV
2
CPXA_ECOLI
A:
[29-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
A
R
K
L
K
N
A
A
D
E
V
A
Q
G
N
L
R
Q
H
P
E
L
E
A
G
P
Q
E
F
L
A
A
G
A
S
F
N
Q
M
V
T
A
L
E
------
R
M
M
T
S
Q
Q
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
-
R
R
R
S
G
E
----
S
------------------
K
E
L
E
R
I
E
-
T
E
A
Q
R
L
---------
D
S
M
I
-
N
D
L
L
V
M
S
R
N
-------
Q
Q
K
N
A
L
V
S
E
-------------
T
I
K
A
NQL
W
-----
S
E
V
L
--
D
N
--
A
-----
A
----
F
E
A
E
-----
Q
--
M
-
G
K
S
L
T
V
N
F
P
P
G
P
W
P
L
Y
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
-----
S
H
-------
T
---
K
I
E
V
G
F
A
V
--
D
K
D
G
I
T
--
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
E
------
A
R
D
R
E
S
G
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
-
Q
H
R
G
W
V
K
A
E
--------------
32
HHSearch
66.33
26%
-61
- C3 -
3A0R
1
?
A:
[130-342]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
L
G
E
M
T
A
R
V
A
H
E
I
R
N
P
I
T
I
I
G
G
F
I
M
R
M
-
K
K
H
L
D
D
-----
P
E
T
L
K
K
---
Y
---
I
N
I
I
T
N
E
L
S
R
L
E
-
T
I
V
K
E
I
-----
L
E
Y
S
K
E
R
-----
V
L
E
F
T
E
-------
F
N
L
N
E
L
I
R
E
-------------
V
Y
V
L
---
F
-----
E
E
K
I
--
R
K
--
M
-----
N
----
I
D
F
C
F
E
---
T
--
D
-
N
E
D
L
R
V
E
A
D
R
T
R
I
---------
K
Q
V
L
I
N
L
V
Q
N
A
I
E
A
---
T
G
E
N
-------
G
---
K
I
K
I
T
S
E
D
--
M
Y
T
K
V
R
--
V
S
V
W
N
S
G
P
P
I
P
E
E
L
K
E
K
I
F
S
P
F
F
T
T
------------------
L
G
L
S
I
C
R
K
I
I
E
D
E
H
G
G
K
I
W
T
E
N
R
-
E
N
G
V
V
F
I
F
E
I
-
10
PsiBlast_PDB
65.67
26%
-32
- C3 -
4BIW
4
CPXA_ECOLI
A:
[52-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
A
G
P
Q
E
F
L
A
A
G
A
S
F
N
Q
V
V
T
A
L
E
------
R
M
M
T
S
Q
Q
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
-
R
R
R
S
G
E
----
S
-----
K
---
E
---
L
E
R
I
E
T
E
A
Q
R
L
D
-
S
M
I
N
D
L
-----
L
V
M
S
R
N
Q
Q
K
N
A
L
V
S
E
--
T
-------
I
K
A
N
-
Q
L
W
S
-------------
E
V
L
D
----------------
N
--
A
-----
A
----
F
E
A
E
-----
Q
--
M
-
G
K
S
L
T
V
N
F
P
P
G
P
W
P
L
Y
GN
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
-----
S
H
-------
T
---
K
I
E
V
G
F
A
V
--
D
K
D
G
I
T
--
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
E
------
A
R
D
R
E
S
G
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
-
Q
H
R
G
W
V
K
A
E
--------------
28
HHSearch
64.81
18%
-60
- C3 -
2Q8G
1
PDK1_HUMAN
A:
[103-363]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
A
I
Y
D
F
T
D
T
V
I
R
I
R
N
R
H
N
D
V
I
P
T
M
A
Q
G
V
-
I
E
Y
K
E
S
FDPV
T
S
Q
N
V
Q
Y
---
F
---
L
D
R
F
Y
M
S
R
I
S
I
R
-
M
L
L
N
Q
H
-----
S
L
L
F
G
-----------
K
H
IGSINPN
C
N
V
L
E
V
I
K
D
-------------
G
Y
E
N
---
A
-----
R
R
L
C
--
D
L
--
Y
YI
N
S
P
E
----
L
E
L
E
E
L
NAK
S
--
P
-
G
Q
P
I
Q
V
V
Y
V
P
S
H
L
---------
Y
H
M
V
F
E
L
F
K
N
A
M
R
A
---
T
M
E
H
H
ANRG
V
Y
P
---
P
I
Q
V
H
V
T
L
--
G
N
E
D
L
T
--
V
K
M
S
D
R
G
G
G
V
P
L
R
K
I
D
R
L
F
N
Y
M
Y
S
T
A
P
RPRVET
S
R
A
V
P
L
A
G
F
G
Y
G
L
P
I
S
R
L
Y
A
Q
-
Y
F
Q
G
D
L
K
L
Y
S
L
E
G
Y
G
T
D
A
V
I
Y
I
-
11
PsiBlast_PDB
64.13
26%
-47
- C3 -
4BIX
3
CPXA_ECOLI
A:
[61-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
G
A
S
F
N
Q
V
V
T
A
L
E
------
R
M
M
T
S
Q
Q
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
-
R
R
R
S
G
E
----
S
-----
K
---
E
---
L
E
R
I
E
T
E
A
Q
R
L
D
-
S
M
I
N
D
L
-----
L
V
M
S
R
N
Q
Q
K
N
A
L
V
S
E
--
T
-------
I
K
A
N
-
Q
L
W
S
-------------
E
V
L
D
----------------
N
--
A
-----
A
----
F
E
A
E
-----
Q
--
M
-
G
K
S
L
T
V
N
F
P
P
G
P
W
P
L
Y
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
-----
S
H
-------
T
---
K
I
E
V
G
F
A
V
--
D
K
D
G
I
T
--
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
--------------
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
-
Q
H
R
G
W
V
K
A
E
--------------
20
PsiBlast_PDB
63.33
25%
-23
- C3 -
4KP4
4
ENVZ_ECOLI
A:
[9-219]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
D
R
T
L
L
M
A
G
V
S
H
D
L
R
T
P
L
T
R
I
R
A
Y
A
E
T
I
Y
N
S
L
G
E
L
----
D
L
S
T
L
K
E
L
A
E
S
---
I
N
K
D
I
E
E
C
N
A
I
I
E
Q
F
I
D
Y
L
R
T
GQE
M
P
M
E
M
A
D
L
-
N
A
V
L
G
E
V
I
A
-------
A
E
S
G
Y
E
---------------------------------------
R
-----
E
----
I
E
T
A
-----
L
--
Y
-
P
G
S
I
E
V
K
M
H
P
L
S
I
---------
K
R
A
V
A
N
M
V
V
N
A
A
R
Y
---
G
--
N
-------
G
---
W
I
K
V
S
S
G
T
--
E
P
N
R
A
W
--
F
Q
V
E
D
D
G
P
G
I
A
P
E
Q
R
K
H
L
F
Q
P
F
V
R
G
D
S
------
A
R
T
I
S
--
G
T
G
L
G
L
A
I
V
Q
R
I
V
D
-
N
H
N
G
M
L
E
L
G
T
S
E
R
G
G
L
S
I
R
----
9
PsiBlast_PDB
60.79
35%
-56
- C3 -
3SL2
2
A:
[4-144]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
-------
V
R
F
M
S
L
I
I
D
-------------
R
F
E
M
---
T
-----
K
E
Q
-------------
E
----
F
I
R
N
-----
L
--
P
-
D
R
D
L
Y
V
E
I
D
Q
D
K
I
---------
T
Q
V
L
D
N
I
I
S
N
A
L
K
Y
---
S
P
E
G
-------
G
---
H
V
T
F
S
I
D
V
--
N
E
E
E
E
L
L
Y
I
S
V
K
D
E
G
I
G
I
P
K
K
D
V
E
K
V
F
D
R
F
Y
R
V
D
------------
L
G
G
T
G
L
G
L
A
I
A
K
E
M
V
Q
-
A
H
G
G
D
I
W
A
D
S
I
E
G
K
G
T
T
------
37
HHSearch
53.42
37%
-57
- C3 -
3SL2
2
A:
[33-149]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
L
Y
V
E
I
D
Q
D
K
I
---------
T
Q
V
L
D
N
I
I
S
N
A
L
K
Y
---
S
P
E
G
-------
G
---
H
V
T
F
S
I
D
V
NE
E
E
E
L
L
Y
--
I
S
V
K
D
E
G
I
G
I
P
K
K
D
V
E
K
V
F
D
R
F
Y
R
V
D
------------
L
G
G
T
G
L
G
L
A
I
A
K
E
M
V
Q
-
A
H
G
G
D
I
W
A
D
S
I
E
G
K
G
T
T
I
T
F
T
L
-