@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1576: (2016-03-27 )
MYQTIIIGGGPSGLMAAVAASEQSSSVLLIEKKKGLGRKLKISGGGRCNVTNRLPYAEIIKNIPGNGKFLYSPFSIFDNESIIDFFESRGVKLKEEDHGRMFPVSNKAQDVVDTLVTTIERQHVTIKEEEAVSRIEVNTDQTFTVHTQNNSYESHSLVIATGGTSVPQTGSTGDGYKFAQDLGHTITELFPTEVPITSAEPFIKSNRLKGLSLKDVELSVLKKNGKKRISHQMDMLFTHFGISGPAALRCSQFVYKEQKNQKTQHISMAIDAFPELNHEQLKQHITSLLSDTPDKIIKNSLHGLIEERYLLFMLEQAGIDENTTSHHLSNQQLNDLVNMFKGFVFKVNGTLPIDKAFVTGGGVSLKEIQPKTMMSKLVPGLFLCGEVLDIHGYTGGYNITSALVTGHVAGLYAGHYSHTSME
Atome Classification :
(20 SA)
-----------------------------------------------------------------------------------------------------------------------------.........10........20........30........40......-..50-----------..-...--------....60--.-----.----------......70........80.--.......90..---...------.--..----100---.-----..--...---..--110.......120.....---...130.....-..-------140.-.------..--.-----..-150-.-.---.......160.------------------...------------------.------------------..170.......180.......190......-.200..----------....-..210.......-.220.......230.......240....-...250.......260.......270.......280.......290..----.....300-.......310.......320---.......330.......340.......350.......360...-....370....--....380......-.-390-...--.....400.......410.......420
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------------------------------------------------------------------------------------M
Y
Q
T
I
I
IGGG
P
S
G
L
M
A
A
V
AASEQS
S
S
V
L
L
I
EKKKGLG
R
K
L
K
ISGGGR-CNV------------TN-RL
P
--------
Y
A
E
I
I
K--N-----I----------PGNG
K
F
L
YS
P
F
SIFD
N
E
S
I
--
I
D
F
F
E
SRG
V
K
L---KEE------D--HG----RM----F-----PV--S
N
K
---
A
Q
--
D
V
V
D
T
L
V
T
T
I
E-RQ
H
V
T
I---
K
E
EEA
V
S
R
I
E
V-NT-------D
Q
T
F
-
T
------
V
H
--T-----QN-N---S-Y---ES
H
S
L
V
I
ATGG------------------TSV------------------P------------------QTGSTGD
G
Y
K
F
A
Q
D
L
G
H
T
I
T
E
LFPTEVPITS-AE-P
F
I
----------
K
SNR-LKG
L
-
S
LK
D
V
E
L
-
S
V
L
K
KN
G
K
K
R
I
S
H
Q
M
D
M
L
F
T
HFGISG
P
A
-
A
L
R
C
S
Q
F
V
Y
K
E
QKNQKT
Q
H
I
S
M
A
I
DAFPEL
N
H
E
Q
L
K
Q
H
I
T
S
L
L
SDT
P
D
----
K
I
I
K
N
S
L
H
-
G
L
I
E
E
R
Y
L
L
F
M
L
E
QAGIDEN---TTSHHL
S
N
Q
Q
L
N
D
L
V
N
M
F
K
G
F
V
F
K
VNGTLPI
D
K
A
F
VTGGG
V
S
L
-
K
EI
Q
P
K
-
T
M
M
S
--
K
L
V
P
G
L
F
L
C
G
E
V
L-D-IH--GYT--GG
Y
N
I
T
S
A
L
V
T
G
H
V
A
G
L
YAGHYSHTSME
1
PsiBlast_PDB
91.26
62%
-102
- C4 -
2I0Z
2
?
A:
[27-441]
------------------------------------------------------------------------------------------------------------------------------
Y
D
V
I
V
I
G
G
G
P
S
G
L
M
A
A
I
G
A
A
E
E
G
A
N
V
L
L
L
D
K
G
N
K
L
G
R
K
L
A
I
S
G
G
G
R
-
C
N
V
------------
T
N
-
R
L
P
--------
L
D
E
I
V
K
--
H
-----
I
----------
P
G
N
G
R
F
L
Y
S
A
F
S
I
F
N
N
E
D
I
--
I
T
F
F
E
N
L
G
V
K
L
---
K
E
E
------
D
--
H
G
----
R
M
----
F
-----
P
V
--
S
N
K
---
A
Q
--
S
V
V
D
A
L
L
T
R
L
K
-
D
L
G
V
K
I
---
R
T
N
T
P
V
E
T
I
E
Y
-
E
N
-------
G
Q
T
K
-
A
------
V
I
--
L
-----
Q
T
-
G
---
E
V
L
---
E
T
N
H
V
V
I
A
V
G
G
------------------
K
S
V
------------------
P
------------------
Q
T
G
S
T
G
D
G
Y
A
W
A
E
K
A
G
H
T
I
T
E
L
F
P
T
E
V
P
I
L
S
-
N
E
-
P
F
I
----------
R
D
R
S
-
L
Q
G
L
-
A
L
R
D
I
N
L
-
S
V
L
N
----
A
I
I
S
H
K
M
D
M
L
F
T
H
F
G
L
S
G
P
A
-
A
L
R
C
S
Q
F
V
V
K
A
L
K
K
F
K
T
N
T
I
Q
M
S
I
D
A
L
P
E
E
N
S
E
Q
L
F
Q
R
M
L
K
Q
M
K
E
D
P
K
----
K
G
I
K
N
V
L
K
-
G
Y
V
P
E
R
Y
F
L
F
L
L
E
K
N
E
I
D
G
S
---
E
Q
A
G
Q
V
S
H
E
K
I
R
A
L
V
K
D
F
K
E
F
T
V
N
V
N
G
T
Q
S
I
E
K
A
F
V
T
G
G
G
V
S
V
-
K
E
I
N
P
K
-
E
M
S
S
--
K
F
T
N
G
L
Y
F
C
G
E
V
L
-
D
-
I
H
--
G
Y
T
--
G
G
Y
N
I
T
S
A
L
V
T
G
R
I
A
G
T
T
A
G
E
-------
104
Fugue
89.43
60%
-98
- C4 -
2I0Z
2
?
A:
[25-444]
----------------------------------------------------------------------------------------------------------------------------M
H
Y
D
V
I
V
I
G
G
G
P
S
G
L
M
A
A
I
G
A
A
E
E
G
A
N
V
L
L
L
D
K
G
N
K
L
G
R
K
L
A
I
S
G
G
G
R
-
C
N
V
------------
T
N
-
R
L
P
--------
L
D
E
I
V
K
--
H
-----
I
----------
P
G
N
G
R
F
L
Y
S
A
F
S
I
F
N
N
E
D
I
--
I
T
F
F
E
N
L
G
V
K
L
---
K
E
E
------
D
--
H
G
----
R
M
----
F
-----
P
V
--
S
N
K
---
A
Q
--
S
V
V
D
A
L
L
T
R
L
K
-
D
L
G
V
K
I
---
R
T
N
T
P
V
E
T
I
E
Y
E
N
G
-------
Q
T
K
A
-
V
------
I
L
--
Q
-----
T
G
-
E
---
V
-
L
---
E
T
N
H
V
V
I
A
V
G
G
------------------
K
S
V
------------------
P
------------------
Q
T
G
S
T
G
D
G
Y
A
W
A
E
K
A
G
H
T
I
T
E
L
F
P
T
E
V
P
I
L
S
-
N
E
-
P
F
I
----------
R
D
R
S
-
L
Q
G
L
-
A
L
R
D
I
N
L
-
S
V
----
L
N
A
I
I
S
H
K
M
D
M
L
F
T
H
F
G
L
S
G
P
A
-
A
L
R
C
S
Q
F
V
V
K
A
L
K
K
F
K
T
N
T
I
Q
M
S
I
D
A
L
P
E
E
N
S
E
Q
L
F
Q
R
M
L
K
Q
M
K
E
D
P
K
----
K
G
I
K
N
V
L
K
-
G
Y
V
P
E
R
Y
F
L
F
L
L
E
K
N
E
I
D
G
S
---
E
Q
A
G
Q
V
S
H
E
K
I
R
A
L
V
K
D
F
K
E
F
T
V
N
V
N
G
T
Q
S
I
E
K
A
F
V
T
G
G
G
V
S
V
-
K
E
I
N
P
K
-
E
M
S
S
--
K
F
T
N
G
L
Y
F
C
G
E
V
L
-
D
-
I
H
--
G
Y
T
--
G
G
Y
N
I
T
S
A
L
V
T
G
R
I
A
G
T
T
A
G
E
N
A
K
----
85
HHSearch
89.14
60%
-98
- C4 -
2I0Z
2
?
A:
[26-444]
-----------------------------------------------------------------------------------------------------------------------------
H
Y
D
V
I
V
I
G
G
G
P
S
G
L
M
A
A
I
G
A
A
E
E
G
A
N
V
L
L
L
D
K
G
N
K
L
G
R
K
L
A
I
S
G
G
G
R
-
C
N
V
------------
T
N
-
R
L
P
--------
L
D
E
I
V
K
H
-
I
-----
P
----------
G
-
N
G
R
F
L
Y
S
A
F
S
I
F
N
N
E
D
I
--
I
T
F
F
E
N
L
G
V
K
L
---
K
E
E
------
D
--
H
G
----
R
M
----
F
-----
P
V
--
S
N
K
---
A
Q
--
S
V
V
D
A
L
L
T
R
L
K
-
D
L
G
V
K
I
---
R
T
N
T
P
V
E
T
I
E
Y
-
E
N
-------
G
Q
T
K
-
A
------
V
I
--
L
-----
Q
T
G
E
---
V
-
L
---
E
T
N
H
V
V
I
A
V
G
G
------------------
K
S
V
------------------
P
------------------
Q
T
G
S
T
G
D
G
Y
A
W
A
E
K
A
G
H
T
I
T
E
L
F
P
T
E
V
P
I
L
S
-
N
E
-
P
F
I
----------
R
D
R
S
-
L
Q
G
L
-
A
L
R
D
I
N
L
S
V
L
N
-----
A
I
I
S
H
K
M
D
M
L
F
T
H
F
G
L
S
G
P
A
-
A
L
R
C
S
Q
F
V
V
K
A
L
K
K
F
K
T
N
T
I
Q
M
S
I
D
A
L
P
E
E
N
S
E
Q
L
F
Q
R
M
L
K
Q
M
K
E
D
P
K
----
K
G
I
K
N
V
L
K
-
G
Y
V
P
E
R
Y
F
L
F
L
L
E
K
N
E
I
D
G
S
---
E
Q
A
G
Q
V
S
H
E
K
I
R
A
L
V
K
D
F
K
E
F
T
V
N
V
N
G
T
Q
S
I
E
K
A
F
V
T
G
G
G
V
S
V
-
K
E
I
N
P
K
-
E
M
S
S
--
K
F
T
N
G
L
Y
F
C
G
E
V
L
-
D
-
I
H
--
G
Y
T
--
G
G
Y
N
I
T
S
A
L
V
T
G
R
I
A
G
T
T
A
G
E
N
A
K
----
22
PsiBlast_CBE
76.88
44%
-93
- C4 -
4CNJ
1
?
D:
[4-386]
------------------------------------------------------------------------------------------------------------------------------
F
D
T
I
I
I
G
G
G
P
A
G
M
M
A
T
I
S
S
S
F
Y
G
Q
K
T
L
L
L
E
K
N
K
R
L
G
K
K
L
A
G
T
G
G
G
R
-
C
N
V
------------
T
N
-
N
G
N
--------
L
D
D
L
M
A
--
G
-----
I
----------
P
G
N
G
R
F
L
Y
S
V
F
S
Q
F
D
N
H
D
I
--
I
N
F
F
T
E
N
G
V
K
L
---
K
V
E
------
D
--
H
G
----
R
V
----
F
-----
P
V
--
T
D
K
---
S
R
--
T
I
I
E
A
L
E
K
K
I
A
-
E
L
G
G
T
V
---
I
T
N
T
E
I
V
S
V
K
--
K
T
-------
D
E
L
F
-
T
------
V
R
--
S
-----
S
D
-
Q
---
A
-
W
---
T
C
Q
K
L
I
V
T
T
G
G
------------------
K
S
Y
------------------
P
------------------
S
T
G
S
T
G
F
G
H
D
I
A
R
H
F
K
H
T
V
T
D
L
E
A
A
E
S
P
L
L
T
-
D
F
-
P
-------------
H
K
A
-
L
Q
G
I
-
S
L
D
D
V
T
L
-
S
Y
----
G
K
H
I
I
T
H
--
D
L
L
F
T
H
F
G
L
S
G
P
A
-
A
L
R
L
S
S
F
V
K
G
G
E
--------
T
I
Y
L
D
V
L
P
Q
M
S
----
Q
Q
D
L
A
D
F
L
E
E
H
R
E
----
K
S
L
K
N
C
L
K
-
I
L
L
P
E
R
I
A
D
F
F
T
Q
P
--
F
P
E
K
---
V
K
Q
L
N
L
S
E
K
E
A
--
L
I
K
Q
I
K
E
L
P
I
S
V
T
G
K
M
S
L
A
K
S
F
V
T
K
G
G
V
S
L
-
K
E
I
N
P
K
-
T
L
E
S
--
K
L
V
P
G
L
H
F
A
G
E
V
L
-
D
-
I
N
--
A
H
T
--
G
G
F
N
I
T
S
A
L
C
T
G
W
V
A
G
------------
21
PsiBlast_CBE
76.60
44%
-93
- C4 -
4CNK
13
?
B:
[4-386]
------------------------------------------------------------------------------------------------------------------------------
F
D
T
I
I
I
G
G
G
P
A
G
M
M
A
T
I
S
S
S
F
Y
G
Q
K
T
L
L
L
E
K
N
K
R
L
G
K
K
L
A
G
T
G
G
G
R
-
C
N
V
------------
T
N
-
N
G
N
--------
L
D
D
L
M
A
--
G
-----
I
----------
P
G
N
G
R
F
L
Y
S
V
F
S
Q
F
D
N
H
D
I
--
I
N
F
F
T
E
N
G
V
K
L
---
K
V
E
------
D
--
H
G
----
R
V
----
F
-----
P
V
--
T
D
K
---
S
R
--
T
I
I
E
A
L
E
K
K
I
A
-
E
L
G
G
T
V
---
I
T
N
T
E
I
V
S
V
K
--
K
T
-------
D
E
L
F
-
T
------
V
R
--
S
-----
S
D
-
Q
---
A
-
W
---
T
C
Q
K
L
I
V
T
T
G
G
------------------
K
S
Y
------------------
P
------------------
S
T
G
S
T
G
F
G
H
D
I
A
R
H
F
K
H
T
V
T
D
L
E
A
A
E
S
P
L
L
T
-
D
F
-
P
-------------
H
K
A
-
L
Q
G
I
-
S
L
D
D
V
T
L
-
S
Y
----
G
K
H
I
I
T
H
--
D
L
L
F
T
H
F
G
L
S
G
P
A
-
A
L
R
L
S
S
F
V
K
G
G
E
--------
T
I
Y
L
D
V
L
P
Q
M
S
----
Q
Q
D
L
A
D
F
L
E
E
H
R
E
----
K
S
L
K
N
C
L
K
-
I
L
L
P
E
R
I
A
D
F
F
T
Q
P
--
F
P
E
K
---
V
K
Q
L
N
L
S
E
K
E
A
--
L
I
K
Q
I
K
E
L
P
I
S
V
T
G
K
M
S
L
A
K
S
F
V
T
K
G
G
V
S
L
-
K
E
I
N
P
K
-
T
L
E
S
--
K
L
V
P
G
L
H
F
A
G
E
V
L
-
D
-
I
N
--
A
H
T
--
G
G
F
N
I
T
S
A
L
C
T
G
W
V
A
G
------------
2
PsiBlast_PDB
76.47
44%
-92
- C4 -
4CNJ
1
?
A:
[4-386]
------------------------------------------------------------------------------------------------------------------------------
F
D
T
I
I
I
G
G
G
P
A
G
M
M
A
T
I
S
S
S
F
Y
G
Q
K
T
L
L
L
E
K
N
K
R
L
G
K
K
L
A
G
T
G
G
G
R
-
C
N
V
------------
T
N
-
N
G
N
--------
L
D
D
L
M
A
--
G
-----
I
----------
P
G
N
G
R
F
L
Y
S
V
F
S
Q
F
D
N
H
D
I
--
I
N
F
F
T
E
N
G
V
K
L
---
K
V
E
------
D
--
H
G
----
R
V
----
F
-----
P
V
--
T
D
K
---
S
R
--
T
I
I
E
A
L
E
K
K
I
A
-
E
L
G
G
T
V
---
I
T
N
T
E
I
V
S
V
K
--
K
T
-------
D
E
L
F
-
T
------
V
R
--
S
-----
S
D
-
Q
---
A
-
W
---
T
C
Q
K
L
I
V
T
T
G
G
------------------
K
S
Y
------------------
P
------------------
S
T
G
S
T
G
F
G
H
D
I
A
R
H
F
K
H
T
V
T
D
L
E
A
A
E
S
P
L
L
T
-
D
F
-
P
-------------
H
K
A
-
L
Q
G
I
-
S
L
D
D
V
T
L
-
S
Y
----
G
K
H
I
I
T
H
--
D
L
L
F
T
H
F
G
L
S
G
P
A
-
A
L
R
L
S
S
F
V
K
G
G
E
--------
T
I
Y
L
D
V
L
P
Q
M
S
----
Q
Q
D
L
A
D
F
L
E
E
H
R
E
----
K
S
L
K
N
C
L
K
-
I
L
L
P
E
R
I
A
D
F
F
T
Q
P
--
F
P
E
K
---
V
K
Q
L
N
L
S
E
K
E
A
--
L
I
K
Q
I
K
E
L
P
I
S
V
T
G
K
M
S
L
A
K
S
F
V
T
K
G
G
V
S
L
-
K
E
I
N
P
K
-
T
L
E
S
--
K
L
V
P
G
L
H
F
A
G
E
V
L
-
D
-
I
N
--
A
H
T
--
G
G
F
N
I
T
S
A
L
C
T
G
W
V
A
G
------------
3
PsiBlast_PDB
76.18
44%
-93
- C4 -
4CNK
11
?
A:
[4-386]
------------------------------------------------------------------------------------------------------------------------------
F
D
T
I
I
I
G
G
G
P
A
G
M
M
A
T
I
S
S
S
F
Y
G
Q
K
T
L
L
L
E
K
N
K
R
L
G
K
K
L
A
G
T
G
G
G
R
-
C
N
V
------------
T
N
-
N
G
N
--------
L
D
D
L
M
A
--
G
-----
I
----------
P
G
N
G
R
F
L
Y
S
V
F
S
Q
F
D
N
H
D
I
--
I
N
F
F
T
E
N
G
V
K
L
---
K
V
E
------
D
--
H
G
----
R
V
----
F
-----
P
V
--
T
D
K
---
S
R
--
T
I
I
E
A
L
E
K
K
I
A
-
E
L
G
G
T
V
---
I
T
N
T
E
I
V
S
V
K
--
K
T
-------
D
E
L
F
-
T
------
V
R
--
S
-----
S
D
-
Q
---
A
-
W
---
T
C
Q
K
L
I
V
T
T
G
G
------------------
K
S
Y
------------------
P
------------------
S
T
G
S
T
G
F
G
H
D
I
A
R
H
F
K
H
T
V
T
D
L
E
A
A
E
S
P
L
L
T
-
D
F
-
P
-------------
H
K
A
-
L
Q
G
I
-
S
L
D
D
V
T
L
-
S
Y
----
G
K
H
I
I
T
H
--
D
L
L
F
T
H
F
G
L
S
G
P
A
-
A
L
R
L
S
S
F
V
K
G
G
E
--------
T
I
Y
L
D
V
L
P
Q
M
S
----
Q
Q
D
L
A
D
F
L
E
E
H
R
E
----
K
S
L
K
N
C
L
K
-
I
L
L
P
E
R
I
A
D
F
F
T
Q
P
--
F
P
E
K
---
V
K
Q
L
N
L
S
E
K
E
A
--
L
I
K
Q
I
K
E
L
P
I
S
V
T
G
K
M
S
L
A
K
S
F
V
T
K
G
G
V
S
L
-
K
E
I
N
P
K
-
T
L
E
S
--
K
L
V
P
G
L
H
F
A
G
E
V
L
-
D
-
I
N
--
A
H
T
--
G
G
F
N
I
T
S
A
L
C
T
G
W
V
A
G
------------
24
PsiBlast_CBE
75.83
44%
-93
- C4 -
4CNJ
1
?
B:
[4-386]
------------------------------------------------------------------------------------------------------------------------------
F
D
T
I
I
I
G
G
G
P
A
G
M
M
A
T
I
S
S
S
F
Y
G
Q
K
T
L
L
L
E
K
N
K
R
L
G
K
K
L
A
G
T
G
G
G
R
-
C
N
V
------------
T
N
-
N
G
N
--------
L
D
D
L
M
A
--
G
-----
I
----------
P
G
N
G
R
F
L
Y
S
V
F
S
Q
F
D
N
H
D
I
--
I
N
F
F
T
E
N
G
V
K
L
---
K
V
E
------
D
--
H
G
----
R
V
----
F
-----
P
V
--
T
D
K
---
S
R
--
T
I
I
E
A
L
E
K
K
I
A
-
E
L
G
G
T
V
---
I
T
N
T
E
I
V
S
V
K
--
K
T
-------
D
E
L
F
-
T
------
V
R
--
S
-----
S
D
-
Q
---
A
-
W
---
T
C
Q
K
L
I
V
T
T
G
G
------------------
K
S
Y
------------------
P
------------------
S
T
G
S
T
G
F
G
H
D
I
A
R
H
F
K
H
T
V
T
D
L
E
A
A
E
S
P
L
L
T
-
D
F
-
P
-------------
H
K
A
-
L
Q
G
I
-
S
L
D
D
V
T
L
-
S
Y
----
G
K
H
I
I
T
H
--
D
L
L
F
T
H
F
G
L
S
G
P
A
-
A
L
R
L
S
S
F
V
K
G
G
E
--------
T
I
Y
L
D
V
L
P
Q
M
S
----
Q
Q
D
L
A
D
F
L
E
E
H
R
E
----
K
S
L
K
N
C
L
K
-
I
L
L
P
E
R
I
A
D
F
F
T
Q
P
--
F
P
E
K
---
V
K
Q
L
N
L
S
E
K
E
A
--
L
I
K
Q
I
K
E
L
P
I
S
V
T
G
K
M
S
L
A
K
S
F
V
T
K
G
G
V
S
L
-
K
E
I
N
P
K
-
T
L
E
S
--
K
L
V
P
G
L
H
F
A
G
E
V
L
-
D
-
I
N
--
A
H
T
--
G
G
F
N
I
T
S
A
L
C
T
G
W
V
A
G
------------
23
PsiBlast_CBE
75.60
44%
-91
- C4 -
4CNJ
1
?
C:
[4-386]
------------------------------------------------------------------------------------------------------------------------------
F
D
T
I
I
I
G
G
G
P
A
G
M
M
A
T
I
S
S
S
F
Y
G
Q
K
T
L
L
L
E
K
N
K
R
L
G
K
K
L
A
G
T
G
G
G
R
-
C
N
V
------------
T
N
-
N
G
N
--------
L
D
D
L
M
A
--
G
-----
I
----------
P
G
N
G
R
F
L
Y
S
V
F
S
Q
F
D
N
H
D
I
--
I
N
F
F
T
E
N
G
V
K
L
---
K
V
E
------
D
--
H
G
----
R
V
----
F
-----
P
V
--
T
D
K
---
S
R
--
T
I
I
E
A
L
E
K
K
I
A
-
E
L
G
G
T
V
---
I
T
N
T
E
I
V
S
V
K
--
K
T
-------
D
E
L
F
-
T
------
V
R
--
S
-----
S
D
-
Q
---
A
-
W
---
T
C
Q
K
L
I
V
T
T
G
G
------------------
K
S
Y
------------------
P
------------------
S
T
G
S
T
G
F
G
H
D
I
A
R
H
F
K
H
T
V
T
D
L
E
A
A
E
S
P
L
L
T
-
D
F
-
P
-------------
H
K
A
-
L
Q
G
I
-
S
L
D
D
V
T
L
-
S
Y
----
G
K
H
I
I
T
H
--
D
L
L
F
T
H
F
G
L
S
G
P
A
-
A
L
R
L
S
S
F
V
K
G
G
E
--------
T
I
Y
L
D
V
L
P
Q
M
S
----
Q
Q
D
L
A
D
F
L
E
E
H
R
E
----
K
S
L
K
N
C
L
K
-
I
L
L
P
E
R
I
A
D
F
F
T
Q
P
--
F
P
E
K
---
V
K
Q
L
N
L
S
E
K
E
A
--
L
I
K
Q
I
K
E
L
P
I
S
V
T
G
K
M
S
L
A
K
S
F
V
T
K
G
G
V
S
L
-
K
E
I
N
P
K
-
T
L
E
S
--
K
L
V
P
G
L
H
F
A
G
E
V
L
-
D
-
I
N
--
A
H
T
--
G
G
F
N
I
T
S
A
L
C
T
G
W
V
A
G
------------
4
PsiBlast_PDB
68.34
30%
-86
- C4 -
2GQF
2
Y933_HAEIN
A:
[6-396]
-------------------------------------------------------------------------------------------------------------------------------
E
N
I
I
I
G
A
G
A
A
G
L
F
C
A
A
Q
L
A
K
L
G
K
S
V
T
V
F
D
N
G
K
K
I
G
R
K
I
L
M
S
G
G
G
F
-
C
N
F
------------
T
N
L
E
V
T
--------
P
A
H
Y
L
S
--
Q
-----
N
----------
P
---
H
F
V
K
S
A
L
A
R
Y
T
N
W
D
F
--
I
S
L
V
A
E
Q
G
I
T
Y
---
H
E
K
------
E
--
L
G
----
Q
L
----
F
------
C
--
D
E
G
---
A
E
--
Q
I
V
E
M
L
K
S
E
C
D
-
K
Y
G
A
K
I
L
L
R
S
E
V
S
Q
V
E
R
I
Q
N
-
D
E
-------
K
V
R
F
-
V
------
L
Q
--
V
-----
N
S
-
T
---
Q
-
W
---
Q
C
K
N
L
I
V
A
T
G
G
------------------
L
S
M
------------------
P
------------------
G
L
G
A
T
P
F
G
Y
Q
I
A
E
Q
F
G
I
P
V
I
P
P
R
A
S
L
V
P
F
T
Y
-
R
E
-
T
D
K
----------
F
L
T
A
-
L
S
G
I
-
S
L
P
---
V
-
T
I
T
A
L
C
G
K
---
S
F
Y
N
Q
L
L
F
T
H
R
G
I
S
G
P
A
-
V
L
Q
I
S
N
Y
W
------
Q
P
T
E
--
S
V
E
I
D
L
L
P
--
N
H
-
N
V
E
E
E
I
N
Q
A
K
Q
S
S
P
K
----
Q
M
L
K
T
I
L
V
-
R
L
L
P
K
K
L
V
E
L
W
I
E
Q
-
G
I
V
Q
D
---
E
V
I
A
N
I
S
K
V
R
V
K
N
L
V
D
F
I
H
H
W
E
F
T
P
N
G
T
E
G
Y
R
T
A
E
V
T
M
G
G
V
D
T
-
K
V
I
S
S
K
-
T
M
E
S
--
N
Q
V
S
G
L
Y
F
I
G
E
V
L
-
D
-
V
T
--
G
W
L
--
G
G
Y
N
F
Q
W
A
W
S
S
A
Y
A
C
A
L
-----------
86
HHSearch
66.24
31%
-76
- C4 -
2GQF
2
Y933_HAEIN
A:
[4-401]
-----------------------------------------------------------------------------------------------------------------------------
Y
S
E
N
I
I
I
G
A
G
A
A
G
L
F
C
A
A
Q
L
A
K
L
G
K
S
V
T
V
F
D
N
G
K
K
I
G
R
K
I
L
M
S
G
G
G
F
-
C
N
F
------------
T
N
-
L
E
V
--------
T
P
A
--
H
--
Y
-----
L
----------
S
Q
N
P
H
F
V
K
S
A
L
A
R
Y
T
N
W
D
F
--
I
S
L
V
A
E
Q
G
I
T
Y
---
H
E
K
------
E
--
L
G
----
Q
L
----
F
-----
C
D
---
E
G
---
A
E
--
Q
I
V
E
M
L
K
S
E
C
D
-
K
Y
G
A
K
I
---
L
L
R
S
E
V
S
Q
V
E
R
-
I
Q
N------
D
E
K
V
R
F
------
V
L
--
Q
-----
V
N
S
T
---
Q
-
W
---
Q
C
K
N
L
I
V
A
T
G
G
------------------
L
S
M
------------------
P
------------------
G
L
G
A
T
P
F
G
Y
Q
I
A
E
Q
F
G
I
P
V
I
P
P
R
A
S
L
V
P
F
T
Y
-
R
E
-
T
D
K
----------
F
L
T
A
-
L
S
G
I
-
S
L
P
V
--
T
-
I
T
A
-
L
C
G
---
K
S
F
Y
N
Q
L
L
F
T
H
R
G
I
S
G
P
A
-
V
L
Q
I
S
N
Y
W
Q
P
T
--------
E
S
V
E
I
D
L
L
P
N
H
N
V
E
E
E
I
N
Q
A
K
Q
---
S
S
P
K
----
Q
M
L
K
T
I
L
V
-
R
L
L
P
K
K
L
V
E
L
W
I
E
Q
G
-
I
V
Q
D
---
E
V
I
A
N
I
S
K
V
R
V
K
N
L
V
D
F
I
H
H
W
E
F
T
P
N
G
T
E
G
Y
R
T
A
E
V
T
M
G
G
V
D
T
-
K
V
I
S
S
K
-
T
M
E
S
--
N
Q
V
S
G
L
Y
F
I
G
E
V
L
-
D
-
V
T
--
G
W
L
--
G
G
Y
N
F
Q
W
A
W
S
S
A
Y
A
C
A
L
S
I
S
R
Q
------
84
HHSearch
65.43
28%
-79
- C4 -
3V76
1
?
A:
[28-417]
------------------------------------------------------------------------------------------------------------------------------
Q
D
V
V
I
I
G
A
G
A
A
G
M
M
C
A
I
E
A
G
K
R
G
R
R
V
L
V
I
D
H
A
R
A
P
G
E
K
I
R
I
S
G
G
G
R
-
C
N
F
------------
T
N
-
I
H
A
S-------
P
R
N
F
----
L
----------------
S
G
N
P
H
F
C
K
S
A
L
A
R
Y
R
P
Q
D
F
--
V
A
L
V
E
R
H
G
I
G
W
---
H
E
K
------
T
--
L
G
----
Q
L
----
F
-----
C
---
D
H
S
---
A
K
--
D
I
I
R
M
L
M
A
E
M
K
-
E
A
G
V
Q
L
---
R
L
E
T
S
I
G
E
V
E
R
-
T
A
--------
S
G
F
-
R
------
V
T
--
T
-----
S
A
-
G
---
T
-
V
---
D
A
A
S
L
V
V
A
S
G
G
------------------
K
S
I
------------------
P
------------------
K
M
G
A
T
G
L
A
Y
R
I
A
E
Q
F
G
L
P
V
V
E
T
R
P
A
L
V
P
L
T
L
-
D
Q
-
A
Q
L
A
---------
K
L
G
A
-
L
A
G
V
-
A
A
D
A
E
A
R
-
F
G
-------
K
A
A
F
R
E
A
V
L
I
T
H
R
G
L
S
G
P
A
-
I
L
Q
I
S
S
Y
W
R
E
G
E
--------
E
I
V
L
R
L
M
P
D
I
D
I
A
S
I
L
K
G
M
R
R
A
---
N
G
R
----
Q
A
V
Q
T
A
L
A
-
D
I
L
P
R
R
L
A
Q
F
F
A
D
E
A
K
L
T
-
G
---
R
M
L
A
D
L
S
D
K
T
I
D
A
L
A
S
S
I
Q
V
W
A
V
K
P
A
G
S
E
G
Y
R
T
A
E
V
T
L
G
G
V
D
T
-
R
A
L
D
S
R
-
T
M
Q
A
--
K
E
V
P
G
L
Y
F
V
G
E
C
V
-
D
-
V
T
--
G
W
L
--
G
G
Y
N
F
Q
W
A
W
A
S
G
F
V
A
G
Q
D
V
---------
5
PsiBlast_PDB
61.53
27%
-75
- C4 -
3V76
1
?
A:
[46-414]
------------------------------------------------------------------------------------------------------------------------------------------------
A
G
K
R
G
R
R
V
L
V
I
D
H
A
R
A
P
G
E
K
I
R
I
S
G
G
G
R
-
C
N
F
------------
T
N
---
I
--------
H
A
S
P
R
N
--
F
-----
L
----------
S
G
N
P
H
F
C
K
S
A
L
A
R
Y
R
P
Q
D
F
--
V
A
L
V
E
R
H
G
I
G
W
---
H
E
K
------
T
--
L
G
----
Q
L
----
F
------
C
--
D
H
S
---
A
K
--
D
I
I
R
M
L
M
A
E
M
K
-
E
A
G
V
Q
L
---
R
L
E
T
S
I
G
E
V
E
--
R
T
-------
A
S
G
F
-
R
------
V
T
--
T
-----
S
A
-
G
---
T
-
V
---
D
A
A
S
L
V
V
A
S
G
G
------------------
K
S
I
------------------
P
------------------
K
M
G
A
T
G
L
A
Y
R
I
A
E
Q
F
G
L
P
V
V
E
T
R
P
A
L
V
P
L
T
-------
L
----------
D
Q
A
Q
-
L
A
K
L
G
A
L
A
G
V
A
A
-
D
A
E
A
R
F
G
K
A
--
A
F
R
E
A
V
L
I
T
H
R
G
L
S
G
P
A
-
I
L
Q
I
S
S
Y
-
W
R
E
G
E
E
-------
I
V
L
R
L
M
P
D
I
D
-------
I
A
S
I
L
K
G
M
R
R
A
NGR
Q
A
V
Q
T
A
L
A
-
D
I
L
P
R
R
L
A
Q
F
F
A
D
E
A
K
L
T
G
R
---
M
L
A
D
-
L
S
D
K
T
I
D
A
L
A
S
S
I
Q
V
W
A
V
K
P
A
G
S
E
G
Y
R
T
A
E
V
T
L
G
G
V
D
T
-
R
A
L
D
S
R
-
T
M
Q
A
--
K
E
V
P
G
L
Y
F
V
G
E
C
V
-
D
-
V
T
--
G
W
L
--
G
G
Y
N
F
Q
W
A
W
A
S
G
F
V
A
G
------------
109
Fugue
51.91
18%
-39
* C3 *
1JRX
7
FRDA_SHEFR
A:
[1-568]
ADN
L
A
E
F
H
V
QNQECDSCHTPDGELSNDSL
T
Y
E
N
T
Q
C
V
S
C
HGT
L
A
E
V
A
E
T
T
KHEHYNAHASHFPGEVACTSCHSAH
E
K
S
M
V
YCDSCHSFDFNMPYAK
K
W
L
R
D
E
P
T
IAELAKD
K
S
E
R
Q
A
A
L
A
SAPHD
T
V
D
V
V
V
V
G
S
G
G
A
G
F
S
A
A
I
S
A
T
D
S
G
A
K
V
I
L
I
E
K
E
P
V
I
G
G
N
A
K
L
A
A
G
G
M
-
N
A
A
WT
D
Q
Q
K
A
K
K
I
T
D
S
P
-
E
L
M
--------
F
E
D
T
M
K
--
G
-----
G
----------
Q
N
I
N
D
P
A
L
V
K
V
L
S
S
H
S
K
D
S
--
V
D
W
M
T
A
M
G
A
D
L
---
T
D
V
G
M
M
G
GA
S
--
V
N
----
R
A
----
H
-----
R
P
--
T
G
G
AG
V
G
A
--
H
V
V
Q
V
L
Y
D
N
A
V
-
K
R
N
I
D
L
---
R
M
N
T
R
G
I
E
V
L
K
-
D
D
-------
K
G
T
V
-
K
G
I
L
---
V
K
--
G
-----
M
Y
-
K
G
Y
Y
W
-
V
---
K
A
D
A
V
I
L
A
T
G
G
FAKN
N
E
R
V
A
K
L
DPSLKGF
I
S
T
------------------
N
------------------
Q
P
G
A
V
G
D
G
L
D
V
A
E
N
A
G
G
A
L
K
D
M
Q
Y
I
Q
A
H
P
T
L
-
S
V
-
K
-------------
G
G
V
-
M
V
T
E
-
A
V
R
G
N
G
A
-
I
L
V
N
R
E
G
K
R
F
V
N
-----------------
E
I
T
T
A
D
K
A
S
A
A
I
L
A
Q
T
G
K
S
A
Y
L
I
F
D
D
S
V
R
K
S
L
S
K
I
D
K
Y
I
G
L
G
V
A
P
T
A
D
----
S
L
V
K
L
G
K
M
E
G
I
D
G
K
A
L
T
E
T
V
A
R
Y
N
S
L
V
S
S
---
G
K
D
T
D
F
E
R
P
N
L
P
R
A
L
N
E
G
N
Y
Y
A
I
E
V
T
P
G
V
-----
H
H
T
M
G
G
V
M
I
D
T
K
A
E
V
M
-
N
A
K
K
--
Q
V
I
P
G
L
Y
G
A
G
E
V
T
G
G
-
V
H
--
G
A
N
RL
G
G
N
A
I
S
D
I
I
T
F
G
R
L
A
G
E
E
A
A
K
Y
S
-----
110
Fugue
50.07
17%
-39
- C3 -
1QJD
8
FRDA_SHEFR
A:
[1-568]
ADN
L
A
E
F
H
V
QNQECDSCHTPDGELSNDSL
T
Y
E
N
T
Q
C
V
S
C
HGT
L
A
E
V
A
E
T
T
KHEHYNAHASHFPGEVACTSCHSAH
E
K
S
M
V
YCDSCHSFDFNMPYAK
K
W
L
R
D
E
P
T
IAELAKDK
S
E
R
Q
A
A
L
A
SAPHD
T
V
D
V
V
V
V
G
S
G
G
A
G
F
S
A
A
I
S
A
T
D
S
G
A
K
V
I
L
I
E
K
E
P
V
I
G
G
N
A
K
L
A
A
G
G
M
-
N
A
A
WT
D
Q
Q
K
A
K
K
I
T
D
S
P
-
E
L
M
--------
F
E
D
T
M
K
--
G
-----
G
----------
Q
N
I
N
D
P
A
L
V
K
V
L
S
S
H
S
K
D
S
--
V
D
W
M
T
A
M
G
A
D
L
---
T
D
V
G
M
M
G
GA
S
--
V
N
----
R
A
----
H
R
P
T
--
G
G
--
A
G
V
---
G
A
--
H
V
V
Q
V
L
Y
D
N
A
V
-
K
R
N
I
D
L
---
R
M
N
T
R
G
I
E
V
L
K
-
D
D
-------
K
G
T
V
-
K
G
I
L
V
K
G
M
Y
--
K
-----
G
Y
-
Y
---
W
-
V
---
K
A
D
A
V
I
L
A
T
G
G
FAKN
N
E
R
V
A
K
L
DPSLKGF
I
S
T
------------------
N
------------------
Q
P
G
A
V
G
D
G
L
D
V
A
E
N
A
G
G
A
L
K
D
M
Q
Y
I
Q
A
H
P
T
L
-
S
V
-
K
-------------
G
G
V
-
M
V
T
E
-
A
V
R
G
N
G
A
-
I
L
V
N
R
E
G
K
R
F
V
N
-----------------
E
I
T
T
R
D
K
A
S
A
A
I
L
A
Q
T
G
K
S
A
Y
L
I
F
D
D
S
V
R
K
S
L
S
K
I
D
K
Y
I
G
L
G
V
A
P
T
A
D
----
S
L
V
K
L
G
K
M
E
G
I
D
G
K
A
L
T
E
T
V
A
R
Y
N
S
L
V
S
S
---
G
K
D
T
D
F
E
R
P
N
L
P
R
A
L
N
E
G
N
Y
Y
A
I
E
V
T
P
G
V
H
H
T
-----
M
G
G
V
M
I
D
T
K
A
E
V
M
-
N
A
K
K
--
Q
V
I
P
G
L
Y
G
A
G
E
V
T
G
G
-
V
H
--
G
A
N
RL
G
G
N
A
I
S
D
I
I
T
F
G
R
L
A
G
E
E
A
A
K
Y
S
-----
87
HHSearch
47.92
18%
-44
- C4 -
1Y0P
5
FRDA_SHEFR
A:
[126-568]
-----------------------------------------------------------------------------------------------------------------------------
T
V
D
V
V
V
V
G
S
G
G
A
G
F
S
A
A
I
S
A
T
D
S
G
A
K
V
I
L
I
E
K
E
P
V
I
G
G
N
A
K
L
A
A
G
G
M
N
A
A
W
------------
T
D
-
Q
Q
K
A
K
K
I
T
D
S
-
P
E
L
M
F
E
D
-
T
M
K
G
G
Q
N
----------
I
N
D
P
A
L
V
K
V
L
S
S
--
H
S
K
D
S
--
V
D
W
M
T
A
M
G
A
D
L
---
T
D
V
------
G
M
M
G
G
ASVN
R
A
----
H
R
----
P
T
GG
A
G
V
---
G
A
--
H
V
V
Q
V
L
Y
D
N
A
V
-
K
R
N
I
D
L
---
R
M
N
T
R
G
I
E
V
L
K
-
D
D
K------
G
T
V
K
-
G
------
I
L
--
V
K
G
MY-
K
G
Y
Y
---
W
-
V
---
K
A
D
A
V
I
L
A
T
G
G
------------------
F
A
K
N
N
E
R
V
A
K
L
DPSLKGFIST
N
------------------
Q
P
G
A
V
G
D
G
L
D
V
A
E
N
A
G
G
A
L
K
D
M
Q
Y
I
Q
A
H
P
T
L
S
V
K
G
G
V
M
VTE
A
V
R
G
N
G
A
I
L
V
N
-
R
E
G
K
-
R
F
V
N
E
I
T
----------
T
R
D
K
A
S
A
A
I
L
A
Q
T
G
K
S
A
Y
L
-
I
F
D
D
S
V
R
K
S
L
S
K
I
-----
D
K
Y
I
G
L
G
V
A
P
T
A
--
D
S
L
V
K
-
L
G
K
-----------------
M
E
-
G
I
D
G
K
A
L
T
E
T
V
A
R
Y
N
S
L
V
S
------
S
G
K
D
T
D
F
E
R
P
N
L
P
R
A
L
N
E
G
N
Y
Y
A
I
E
V
T
--
P
G
V
H
H
T
M
G
G
V
M
I
-
D
T
K
A
-
E
-
V
M
N
A
KK
Q
V
I
P
G
L
Y
G
A
G
E
V
T
-
G
G
V
H
GA
N
R
L
--
G
G
N
A
I
S
D
I
I
T
F
G
R
L
A
G
E
E
A
A
K
Y
S
-----
6
PsiBlast_PDB
46.46
23%
-24
* C5 *
1QO8
3
FRD2_SHEFN
A:
[123-563]
-------------------------------------------------------------------------------------------------------------------------------
Q
V
L
V
V
G
A
G
S
A
G
F
N
A
S
L
A
A
K
K
A
G
A
N
V
I
L
V
D
K
A
P
F
S
G
G
N
S
M
I
S
A
G
G
M
-
N
A
V
------------
G
T
-
K
Q
Q
--------
T
A
H
G
V
E
--
D
-----
K
V
E
W
F
I
E
D
A
M
K
G
G
R
Q
Q
N
D
I
K
L
V
T
I
L
A
E
Q
S
A
D
G
V
Q
W
L
E
S
L
G
A
N
L
D
D
L
K
R
S
------
G
--
G
A
----
R
V
DR
T
H
R
-----
P
H
--
G
G
K
---
S
S
G
P
E
I
I
D
T
L
R
K
A
A
K
-
E
Q
G
I
D
T
---
R
L
N
S
R
V
V
K
L
V
V
-
N
D
-------
D
H
S
V
-
V
G
A
V
---
V
H
--
G
-----
K
H
-
T
---
G
-
Y
Y
M
I
G
A
K
S
V
V
L
A
T
G
G
YGMN
K
E
M
I
A
Y
Y
RPTMKDM
T
S
S
------------------
N
------------------
N
I
T
A
T
G
D
G
V
L
M
A
K
E
I
G
A
S
M
-----
T
D
I
D
W
V
Q
-
A
H
-
P
T
V
G---------
K
D
S
R
I
L
I
S
E
-
T
V
R
G
V
G
A
-
V
M
V
N
K
D
G
N
R
F
I
S
E
----
L
T
T
R
D
K
A
S
D
A
I
-
L
K
Q
P
G
Q
F
A
W
I
I
F
D
N
Q
L
Y
K
K
A
K
M
-
V
R
G
Y
D
H
L
--
E
M
L
Y
K
------
G
D
T
V
E
----
Q
L
A
K
S
T
G
M
-
K
V
A
D
-------
L
A
K
T
V
S
D
Y
N
G
Y
V
A
S
G
K
D
T
A
F
G
R
A
D
M
P
L
N
M
T
Q
S
P
Y
Y
A
V
K
V
A
P
G
I
H
H
---
T
M
G
G
V
A
I
-
N
T
T
A
S
V
L
D
L
Q
S
--
K
P
I
D
G
L
F
A
A
G
E
V
T
G
G
-
V
H
--
G
Y
N
RL
G
G
N
A
I
A
D
T
V
V
F
G
R
I
A
G
D
N
A
A
K
H
A
-----
111
Fugue
42.75
23%
-58
- C2 -
4NTC
1
?
A:
[2-326]
-----------------------------------------------------------------------------------------------------------------MS
I
G
K
L
L
SNG
A
L
L
V
D
V
L
I
I
G
A
G
P
A
G
L
S
T
A
T
G
L
A
R
Q
L
H
T
A
V
V
F
D
-----------
S
G
V
Y
R
-
N
A
K
------------
T
Q
-
H
M
--------------
H
--
N
-----
V
----------
L
G
-----------
W
D
H
R
N
P
--
A
E
L
R
A
A
G
R
A
D
L
---
T
T
R
------
Y
-----------------------------------------
S
T
I
Q
-
F
Q
N
S
T
I
---
E
A
I
R
Q
V
E
------
T
-------
N
Q
L
F
-
E
------
A
R
D
-
N
-----
E
G
-
H
---
S
-
W
---
Y
G
R
K
V
V
L
A
T
G
V
------------------
R
D
I
------------------
P
------------------
L
D
I
---
E
G
Y
S
E
C
W
A
N
G
I
Y
H
C
------------------------------------------------
L
F
C
D
G
Y
E
E
R
G
Q
E
T
V
G
V
L
A
L
G
P
I
A
N
P
A
R
A
L
H
L
A
R
M
A
L
R
-----
L
S
E
S
V
T
I
Y
T
N
-----
G
N
E
Q
L
A
K
E
I
Q
Q
A
A
E
E
S
P
---------
V
G
A
S
-
G
L
K
F
E
A
R
P
I
R
R
F
E
K
G
D
V
A
K
----
T
V
I
V
H
L
G
E
S
E
S
K
T
E
G
F
L
V
Y
N
P
Q
T
E
V
N
G
P
F
A
K
Q
L
A
L
N
M
T
E
G
G
D
I
-
L
T
T
P
P
F
-
Y
E
T
S
----
V
P
G
V
F
A
V
G
D
C
A
-
T
P
L
K
--
A
V
T
--
P
A
V
S
M
G
S
L
A
A
G
G
L
V
A
Q
L
Q
A
Q
A
L
------
93
HHSearch
41.14
19%
-65
- C4 -
1CHU
-
NADB_ECOLI
A:
[8-245]
-----------------------------------------------------------------------------------------------------------------------------
S
C
D
V
L
I
I
G
S
G
A
A
G
L
S
L
A
L
R
L
A
D
Q
H
-
Q
V
I
V
L
S
K
G
P
V
T
E
-------------
F
------------
D
E
-
T
D
S
--------
I
D
S
H
V
E
D
T
L
-----
I
A
G
AG------
I
C
D
R
H
A
V
E
F
V
A
S
--
N
A
R
S
C
--
V
Q
W
L
I
D
Q
G
V
L
---------------------------------------------------
T
T
L
V
S
K
A
L
N
H
P
N
I
R
V
---
L
E
R
T
N
A
V
D
L
I
V
-
S
D
KIGLPGT
R
R
V
V
-
G
------
A
W
--
V
W
N
RNK
E
T
V
E
---
T
-
C
---
H
A
K
A
V
V
L
A
T
G
G
------------------
A
S
K
------------------
V
YQYTTN------------
P
D
I
S
S
G
D
G
I
A
M
A
W
R
A
G
C
R
V
A
N
L
E
F
N
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
HHSearch
40.27
23%
-35
- C4 -
1QO8
3
FRD2_SHEFN
A:
[121-358]
-----------------------------------------------------------------------------------------------------------------------------
T
T
Q
V
L
V
V
G
A
G
S
A
G
F
N
A
S
L
A
A
K
K
A
G
A
N
V
I
L
V
D
K
A
P
F
S
G
G
N
S
M
I
S
A
G
G
M
-
N
A
V
------------
G
T
-
K
Q
Q
T
A
H
G
V
E
D
K
V
E
W
F
I
E
D
-
A
M
----
K
G
G
RQ------
Q
N
D
I
K
L
V
T
I
L
A
E
--
Q
S
A
D
G
--
V
Q
W
L
E
S
L
G
A
N
L
---
D
D
L
------
K
R
S
G
G
----
A
R
----
V
DR
T
H
R
P
H
GG
K
S
S
---
G
P
--
E
I
I
D
T
L
R
K
A
A
K
-
E
Q
G
I
D
T
---
R
L
N
S
R
V
V
K
L
V
V
-
N
D
D------
H
S
V
V
-
G
------
A
V
V
H
G
KH---
T
G
Y
Y
---
M
-
I
---
G
A
K
S
V
V
L
A
T
G
G
------------------
Y
G
M
------------------
N
K
E
M
I
A
Y
Y
RPTMKDMTSSN
N
I
T
A
T
G
D
G
V
L
M
A
K
E
I
G
A
S
M
T
D
I
D
W
V
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------