@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1854: (2016-03-29 )
MTKDILILAVETSCDETSVSVIKNGRDILSNTVLSQIESHKRFGGVVPEVASRHHVEGITTTINEALVDADVSMEDIDAIAVTEGPGLIGALLIGVNAAKALAFAYDKPLIPVHHIAGHIYANHIEEPLTFPLIALIVSGGHTELVYMKDHLSFEVIGETRDDAVGEAYDKVARTIGLNYPGGPQVDRLAAEGEDTYSFPRVWLDKDSYDFSFSGLKSAVINQLHNQRQKNIPIIEANVATSFQNSVVEVLTFKAIQACKEYSVQRLIVAGGVASNKGLRQSLADQCKVNDIQLTIPSPKLCTDNAAMIGVAGHSLYQQGRFADLALNGHSNIDLEEYSAE
Atome Classification :
(21 SA)
.........10........20........30........40-...--.....50........60........70........80........90........100.......110.......120..---.----..---..130.......140....-...150.......160.......170.......180......--------------.190..-..-...200.......210.......220-.....-....230....-...240.......250..-----.....260.......270.......280.......290.......300.......310.......320.....-..-330.......340-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTK
D
I
L
I
L
A
V
ETSCDE
T
S
V
S
V
I
KN
G
R
D
I
L
S
N
T
V
L
S
Q
I
E
S
H
K
-RFG--GV
V
P
E
V
ASRHHVE
G
I
T
T
T
I
N
E
A
L
VDADVSMED
I
D
A
I
A
VTEGP
G
L
I
G
A
L
L
I
GV
N
A
A
K
A
L
A
F
AYDKPL
I
P
V
H
H
I
A
G
H
I
Y
A
N
H---I----EE---P
L
T
F
P
L
I
A
L
I
VSGG
H
T
E
L
V
-
Y
MKDH
L
S
F
E
V
IGETRD
D
A
V
G
E
A
Y
D
K
V
A
R
T
IGLNYPGGP
Q
V
D
R
--------------LAAEGE-DT-YSFP
R
V
W
LDKDSYDF
S
F
S
G
L
K
S
A
V
---
I
N
Q
L
H
-
N
Q
R
QKNI
P
I
I
E
-A
N
V
A
T
S
F
Q
N
S
V
V
E
V
L
T
F
K
-----
A
I
Q
A
C
K
EYSV
Q
R
L
I
V
AGGVAS
N
K
G
L
R
Q
S
L
A
D
QCKV
N
D
I
Q
L
TIPSPKLCTDN
A
A
M
I
G
VA
G
H
S
L
Y
QQG
R
F
A
D
L
A
L-NG-HSNI
D
L
E
EYSAE--
22
PsiBlast_CBE
98.93
41%
-103
- C5 -
4WQ4
4
TSAD_ECOLI
B:
[3-336]
------
V
L
G
I
E
T
S
C
D
A
T
G
I
A
I
Y
D
D
E
K
G
L
L
A
N
Q
L
Y
S
Q
V
K
L
H
A
-
D
Y
G
--
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
S
G
L
T
A
K
D
I
D
A
V
A
Y
T
A
G
P
G
L
V
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
D
V
P
A
I
P
V
H
H
M
E
G
H
L
L
A
P
M
---
L
----
E
D
N--
P
P
E
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
-
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
L
L
S
K
--------------
M
A
A
Q
G
T
A
G
R
-
F
V
F
P
R
P
M
T
D
R
P
G
L
D
F
S
F
S
G
L
K
T
F
A
---
A
N
T
I
R
-
D
N
G
T
D
D
--
Q
T
R
-
A
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
-----
C
K
R
A
L
D
Q
T
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
K
K
R
R
G
E
V
F
Y
A
R
P
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
G
A
T
A
D
L
G
V
-
S
V
-
R
P
R
W
P
L
A
E
L
P
A
---
2
PsiBlast_PDB
98.56
41%
-102
- C5 -
4WQ4
3
TSAD_ECOLI
A:
[3-336]
------
V
L
G
I
E
T
S
C
D
A
T
G
I
A
I
Y
D
D
E
K
G
L
L
A
N
Q
L
Y
S
Q
V
K
L
H
A
-
D
Y
G
--
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
S
G
L
T
A
K
D
I
D
A
V
A
Y
T
A
G
P
G
L
V
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
D
V
P
A
I
P
V
H
H
M
E
G
H
L
L
A
P
M
---
L
----
E
D
N--
P
P
E
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
-
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
L
L
S
K
--------------
M
A
A
Q
G
T
A
G
R
-
F
V
F
P
R
P
M
T
D
R
P
G
L
D
F
S
F
S
G
L
K
T
F
A
---
A
N
T
I
R
-
D
N
G
T
D
D
--
Q
T
R
-
A
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
-----
C
K
R
A
L
D
Q
T
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
K
K
R
R
G
E
V
F
Y
A
R
P
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
G
A
T
A
D
L
G
V
-
S
V
-
R
P
R
W
P
L
A
E
L
P
A
---
1
PsiBlast_PDB
98.37
41%
-98
- C5 -
4YDU
7
TSAD_ECOLI
A:
[3-336]
------
V
L
G
I
E
T
S
C
D
E
T
G
I
A
I
Y
D
D
E
K
G
L
L
A
N
Q
L
Y
S
Q
V
K
L
H
A
-
D
Y
G
--
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
S
G
L
T
A
K
D
I
D
A
V
A
Y
T
A
G
P
G
L
V
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
D
V
P
A
I
P
V
H
H
M
E
G
H
L
L
A
P
M
---
L
----
E
D
N--
P
P
E
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
-
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
L
L
S
K
--------------
M
A
A
Q
G
T
A
G
R
-
F
V
F
P
R
P
M
T
D
R
P
G
L
D
F
S
F
S
G
L
K
T
F
A
---
A
N
T
I
R
-
D
N
G
T
D
D
--
Q
T
R
-
A
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
-----
C
K
R
A
L
D
Q
T
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
K
K
R
R
G
E
V
F
Y
A
R
P
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
G
A
T
A
D
L
G
V
-
S
V
-
R
P
R
W
P
L
A
E
L
P
A
---
21
PsiBlast_CBE
97.55
41%
-98
- C5 -
4YDU
7
TSAD_ECOLI
B:
[3-336]
------
V
L
G
I
E
T
S
C
D
E
T
G
I
A
I
Y
D
D
E
K
G
L
L
A
N
Q
L
Y
S
Q
V
K
L
H
A
-
D
Y
G
--
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
S
G
L
T
A
K
D
I
D
A
V
A
Y
T
A
G
P
G
L
V
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
D
V
P
A
I
P
V
H
H
M
E
G
H
L
L
A
P
M
---
L
----
E
D
N--
P
P
E
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
-
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
L
L
S
K
--------------
M
A
A
Q
G
T
A
G
R
-
F
V
F
P
R
P
M
T
D
R
P
G
L
D
F
S
F
S
G
L
K
T
F
A
---
A
N
T
I
R
-
D
N
G
T
D
D
--
Q
T
R
-
A
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
-----
C
K
R
A
L
D
Q
T
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
K
K
R
R
G
E
V
F
Y
A
R
P
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
G
A
T
A
D
L
G
V
-
S
V
-
R
P
R
W
P
L
A
E
L
P
A
---
23
PsiBlast_CBE
97.35
41%
-98
- C5 -
4WQ5
4
TSAD_ECOLI
B:
[3-336]
------
V
L
G
I
E
T
S
C
D
E
T
G
I
A
I
Y
D
D
E
K
G
L
L
A
N
Q
L
Y
S
Q
V
K
L
H
A
-
D
Y
G
--
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
S
G
L
T
A
K
D
I
D
A
V
A
Y
T
A
G
P
G
L
E
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
D
V
P
A
I
P
V
H
H
M
E
G
H
L
L
A
P
M
---
L
----
E
D
N--
P
P
E
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
-
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
L
L
S
K
--------------
M
A
A
Q
G
T
A
G
R
-
F
V
F
P
R
P
M
T
D
R
P
G
L
D
F
S
F
S
G
L
K
T
F
A
---
A
N
T
I
R
-
D
N
G
T
D
D
--
Q
T
R
-
A
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
-----
C
K
R
A
L
D
Q
T
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
K
K
R
R
G
E
V
F
Y
A
R
P
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
G
A
T
A
D
L
G
V
-
S
V
-
R
P
R
W
P
L
A
E
L
P
A
---
24
PsiBlast_CBE
97.16
41%
-100
- C5 -
3ZEU
4
?
E:
[3-336]
------
V
L
G
I
E
T
S
C
D
E
T
G
I
A
I
Y
D
D
K
K
G
L
L
A
N
Q
L
Y
S
Q
V
K
L
H
A
-
D
Y
G
--
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
A
G
L
T
A
S
D
I
D
A
V
A
Y
T
A
G
P
G
L
V
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
N
V
P
A
I
P
V
H
H
M
E
G
H
L
L
A
P
M
---
L
----
E
D
N--
P
P
E
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
-
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
M
L
S
K
--------------
M
A
S
Q
G
T
A
G
R
-
F
V
F
P
R
P
M
T
D
R
P
G
L
D
F
S
F
S
G
L
K
T
F
A
---
A
N
T
I
R
-
S
N
G
G
D
E
--
Q
T
R
-
A
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
-----
C
K
R
A
L
E
S
T
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
Q
K
R
R
G
E
V
F
Y
A
R
P
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
G
V
T
A
D
L
G
V
-
T
V
-
R
P
R
W
P
L
A
E
L
P
A
---
3
PsiBlast_PDB
96.76
41%
-100
- C5 -
4WQ5
5
TSAD_ECOLI
A:
[3-332]
------
V
L
G
I
E
T
S
C
D
E
T
G
I
A
I
Y
D
D
E
K
G
L
L
A
N
Q
L
Y
S
Q
V
K
L
H
A
-
D
Y
G
--
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
S
G
L
T
A
K
D
I
D
A
V
A
Y
T
A
G
P
G
L
E
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
D
V
P
A
I
P
V
H
H
M
E
G
H
L
L
A
P
M
---
L
----
E
D
N--
P
P
E
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
-
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
L
L
S
K
--------------
M
A
A
Q
G
T
A
G
R
-
F
V
F
P
R
P
M
T
D
R
P
G
L
D
F
S
F
S
G
L
K
T
F
A
---
A
N
T
I
R
-
D
N
G
T
D
D
--
Q
T
R
-
A
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
-----
C
K
R
A
L
D
Q
T
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
K
K
R
R
G
E
V
F
Y
A
R
P
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
G
A
T
A
D
L
G
V
-
S
V
-
R
P
R
W
P
L
A
-------
5
PsiBlast_PDB
95.94
41%
-98
- C5 -
3ZEU
5
?
B:
[3-336]
------
V
L
G
I
E
T
S
C
D
E
T
G
I
A
I
Y
D
D
K
K
G
L
L
A
N
Q
L
Y
S
Q
V
K
L
H
A
-
D
Y
G
--
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
A
G
L
T
A
S
D
I
D
A
V
A
Y
T
A
G
P
G
L
V
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
N
V
P
A
I
P
V
H
H
M
E
G
H
L
L
A
P
M
---
L
----
E
D
N--
P
P
E
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
-
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
M
L
S
K
--------------
M
A
S
Q
G
T
A
G
R
-
F
V
F
P
R
P
M
T
D
R
P
G
L
D
F
S
F
S
G
L
K
T
F
A
---
A
N
T
I
R
-
S
N
G
G
D
E
--
Q
T
R
-
A
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
-----
C
K
R
A
L
E
S
T
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
Q
K
R
R
G
E
V
F
Y
A
R
P
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
G
V
T
A
D
L
G
V
-
T
V
-
R
P
R
W
P
L
A
E
L
P
A
---
4
PsiBlast_PDB
95.47
41%
-99
- C5 -
3ZET
2
?
B:
[3-336]
------
V
L
G
I
E
T
S
C
D
E
T
G
I
A
I
Y
D
D
K
K
G
L
L
A
N
Q
L
Y
S
Q
V
K
L
H
A
-
D
Y
G
--
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
A
G
L
T
A
S
D
I
D
A
V
A
Y
T
A
G
P
G
L
V
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
N
V
P
A
I
P
V
H
H
M
E
G
H
L
L
A
P
M
---
L
----
E
D
N--
P
P
E
F
P
F
V
A
L
L
V
S
G
G
H
T
Q
L
I
-
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
M
L
S
K
--------------
M
A
S
Q
G
T
A
G
R
-
F
V
F
P
R
P
M
T
D
R
P
G
L
D
F
S
F
S
G
L
K
T
F
A
---
A
N
T
I
R
-
S
N
G
G
D
E
--
Q
T
R
-
A
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
-----
C
K
R
A
L
E
S
T
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
Q
K
R
R
G
E
V
F
Y
A
R
P
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
G
V
T
A
D
L
G
V
-
T
V
-
R
P
R
W
P
L
A
E
L
P
A
---
90
HHSearch
91.09
38%
-96
- C5 -
3ZEU
5
?
B:
[1-336]
----
M
R
V
L
G
I
E
T
S
C
D
E
T
G
I
A
I
Y
D
D
K
-
K
G
L
L
A
--
N
Q
L
Y
S
Q
V
K
L
H
A
D
YG
G
V
V
P
E
L
A
S
R
D
H
V
R
K
T
V
P
L
I
Q
A
A
L
K
E
A
G
L
T
A
S
D
I
D
A
V
A
Y
T
A
G
P
G
L
V
G
A
L
L
V
G
A
T
V
G
R
S
L
A
F
A
W
N
V
P
A
I
P
V
H
H
M
E
G
H
L
L
A
P
M
---
L
----
E
D
NPP
E
F
P
-
F
V
A
L
L
V
S
G
G
H
T
Q
-
L
I
-
S
V
T
G
I
G
Q
Y
E
L
L
G
E
S
I
D
D
A
A
G
E
A
F
D
K
T
A
K
L
L
G
L
D
Y
P
G
G
P
M
L
S
K
--------------
M
A
S
Q
G
T
-
A
G
R
F
V
F
P
R
P
M
T
D
R
P
G
L
D
F
S
F
S
G
L
K
T
F
A
---
A
N
T
I
R
-
S
N
--
G
G
D
E
Q
T
R
-
A
D
I
A
R
A
F
E
D
A
V
V
D
T
L
M
I
K
-----
C
K
R
A
L
E
S
T
G
F
K
R
L
V
M
A
G
G
V
S
A
N
R
T
L
R
A
K
L
A
E
M
M
Q
K
R
R
G
E
V
F
Y
A
R
P
E
F
C
T
D
N
G
A
M
I
A
Y
A
G
M
V
R
F
K
A
G
V
T
A
D
L
G
V
-
T
V
-
R
P
R
W
P
L
A
E
L
P
A
---
6
PsiBlast_PDB
84.36
32%
-103
- C5 -
2IVN
3
KAE1_PYRAB
A:
[1-301]
----
M
L
A
L
G
I
E
G
T
A
H
T
L
G
I
G
I
V
S
E
D
K
-
V
L
A
N
-
V
F
D
T
L
T
T
E
K
---
G
--
G
I
H
P
K
E
A
A
E
H
H
A
R
L
M
K
P
L
L
R
K
A
L
S
E
A
G
V
S
L
D
D
I
D
V
I
A
F
S
Q
G
P
G
L
G
P
A
L
R
V
V
A
T
A
A
R
A
L
A
V
K
Y
R
K
P
I
V
G
V
N
H
C
I
A
H
V
E
I
T
K
M
F
G
V
----
K
D
---
P
-----
V
G
L
Y
V
S
G
G
N
T
Q
V
L
-
A
L
E
G
G
-
R
Y
R
V
F
G
E
T
L
D
I
G
I
G
N
A
I
D
V
F
A
R
E
L
G
L
G
F
P
G
G
P
K
V
E
K
--------------
L
A
E
K
G
E
-
K
Y
-
I
E
L
P
Y
A
V
---
K
G
M
D
L
S
F
S
G
L
L
T
E
A
---
I
R
K
Y
R
-
S
G
K
Y
R
----
V
E
--
D
L
A
Y
S
F
Q
E
T
A
F
A
A
L
V
E
V
-----
T
E
R
A
V
A
H
T
E
K
D
E
V
V
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
R
I
M
T
E
D
R
G
I
K
F
F
V
P
P
Y
D
L
C
R
D
N
G
A
M
I
A
Y
T
G
L
R
M
Y
K
A
G
-------------------------
8
PsiBlast_PDB
84.34
32%
-104
- C5 -
2IVP
2
KAE1_PYRAB
A:
[1-301]
----
M
L
A
L
G
I
E
G
T
A
H
T
L
G
I
G
I
V
S
E
D
K
-
V
L
A
N
-
V
F
D
T
L
T
T
E
K
---
G
--
G
I
H
P
K
E
A
A
E
H
H
A
R
L
M
K
P
L
L
R
K
A
L
S
E
A
G
V
S
L
D
D
I
D
V
I
A
F
S
Q
G
P
G
L
G
P
A
L
R
V
V
A
T
A
A
R
A
L
A
V
K
Y
R
K
P
I
V
G
V
N
H
C
I
A
H
V
E
I
T
K
M
F
G
V
----
K
D
---
P
-----
V
G
L
Y
V
S
G
G
N
T
Q
V
L
-
A
L
E
G
G
-
R
Y
R
V
F
G
E
T
L
D
I
G
I
G
N
A
I
D
V
F
A
R
E
L
G
L
G
F
P
G
G
P
K
V
E
K
--------------
L
A
E
K
G
E
-
K
Y
-
I
E
L
P
Y
A
V
---
K
G
M
D
L
S
F
S
G
L
L
T
E
A
---
I
R
K
Y
R
-
S
G
K
Y
R
----
V
E
--
D
L
A
Y
S
F
Q
E
T
A
F
A
A
L
V
E
V
-----
T
E
R
A
V
A
H
T
E
K
D
E
V
V
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
R
I
M
T
E
D
R
G
I
K
F
F
V
P
P
Y
D
L
C
R
D
N
G
A
M
I
A
Y
T
G
L
R
M
Y
K
A
G
-------------------------
26
PsiBlast_CBE
84.25
32%
-107
- C5 -
2IVO
3
KAE1_PYRAB
C:
[1-301]
----
M
L
A
L
G
I
E
G
T
A
H
T
L
G
I
G
I
V
S
E
D
K
-
V
L
A
N
-
V
F
D
T
L
T
T
E
K
---
G
--
G
I
H
P
K
E
A
A
E
H
H
A
R
L
M
K
P
L
L
R
K
A
L
S
E
A
G
V
S
L
D
D
I
D
V
I
A
F
S
Q
G
P
G
L
G
P
A
L
R
V
V
A
T
A
A
R
A
L
A
V
K
Y
R
K
P
I
V
G
V
N
H
C
I
A
H
V
E
I
T
K
MFG
V
----
K
D
---
P
-----
V
G
L
Y
V
S
G
G
N
T
Q
V
L
-
A
L
E
G
G
-
R
Y
R
V
F
G
E
T
L
D
I
G
I
G
N
A
I
D
V
F
A
R
E
L
G
L
G
F
P
G
G
P
K
V
E
K
--------------
L
A
E
K
G
E
-
K
Y
-
I
E
L
P
Y
A
V
---
K
G
M
D
L
S
F
S
G
L
L
T
E
A
---
I
R
K
Y
R
-
S
G
K
Y
R
----
V
E
--
D
L
A
Y
S
F
Q
E
T
A
F
A
A
L
V
E
V
-----
T
E
R
A
V
A
H
T
E
K
D
E
V
V
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
R
I
M
T
E
D
R
G
I
K
F
F
V
P
P
Y
D
L
C
R
D
N
G
A
M
I
A
Y
T
G
L
R
M
Y
K
A
G
-------------------------
80
Fugue
84.06
31%
-96
- C5 -
2IVN
3
KAE1_PYRAB
A:
[1-325]
----
M
L
A
L
G
I
E
G
T
A
H
T
L
G
I
G
I
V
S
E
D
K
-
V
L
A
N
V
F
D
T
L
---
T
T
-
E
K
G
--
G
I
H
P
K
E
A
A
E
H
H
A
R
L
M
K
P
L
L
R
K
A
L
S
E
A
G
V
S
L
D
D
I
D
V
I
A
F
S
Q
G
P
G
L
G
P
A
L
R
V
V
A
T
A
A
R
A
L
A
V
K
Y
R
K
P
I
V
G
V
N
H
C
I
A
H
V
E
I
T
K
---
M
----
F
G
---
V
--
K
D
P
V
G
L
Y
V
S
G
G
N
T
Q
V
L
-
A
L
E
G
G
-
R
Y
R
V
F
G
E
T
L
D
I
G
I
G
N
A
I
D
V
F
A
R
E
L
G
L
G
F
P
G
G
P
K
V
E
K
--------------
L
A
E
K
G
E
-
K
Y
-
I
E
L
P
Y
A
V
K
---
G
M
D
L
S
F
S
G
L
L
T
E
A
---
I
R
K
Y
R
-
S
G
K
Y
R
-----
V
-
E
D
L
A
Y
S
F
Q
E
T
A
F
A
A
L
V
E
V
-----
T
E
R
A
V
A
H
T
E
K
D
E
V
V
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
R
I
M
T
E
D
R
G
I
K
F
F
V
P
P
Y
D
L
C
R
D
N
G
A
M
I
A
Y
T
G
L
R
M
Y
K
A
G
I
S
F
R
L
E
E
-
T
I
V
K
Q
K
F
R
T
D
E
V
E
I
V
WH
7
PsiBlast_PDB
83.73
32%
-104
- C5 -
2IVO
3
KAE1_PYRAB
A:
[1-301]
----
M
L
A
L
G
I
E
G
T
A
H
T
L
G
I
G
I
V
S
E
D
K
-
V
L
A
N
-
V
F
D
T
L
T
T
E
K
---
G
--
G
I
H
P
K
E
A
A
E
H
H
A
R
L
M
K
P
L
L
R
K
A
L
S
E
A
G
V
S
L
D
D
I
D
V
I
A
F
S
Q
G
P
G
L
G
P
A
L
R
V
V
A
T
A
A
R
A
L
A
V
K
Y
R
K
P
I
V
G
V
N
H
C
I
A
H
V
E
I
T
K
M
F
G
V
----
K
D
---
P
-----
V
G
L
Y
V
S
G
G
N
T
Q
V
L
-
A
L
E
G
G
-
R
Y
R
V
F
G
E
T
L
D
I
G
I
G
N
A
I
D
V
F
A
R
E
L
G
L
G
F
P
G
G
P
K
V
E
K
--------------
L
A
E
K
G
E
-
K
Y
-
I
E
L
P
Y
A
V
---
K
G
M
D
L
S
F
S
G
L
L
T
E
A
---
I
R
K
Y
R
-
S
G
K
Y
R
----
V
E
--
D
L
A
Y
S
F
Q
E
T
A
F
A
A
L
V
E
V
-----
T
E
R
A
V
A
H
T
E
K
D
E
V
V
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
R
I
M
T
E
D
R
G
I
K
F
F
V
P
P
Y
D
L
C
R
D
N
G
A
M
I
A
Y
T
G
L
R
M
Y
K
A
G
-------------------------
92
HHSearch
83.66
31%
-98
- C5 -
2IVN
3
KAE1_PYRAB
A:
[1-321]
----
M
L
A
L
G
I
E
G
T
A
H
T
L
G
I
G
I
V
S
E
D
-
K
V
L
A
N
V
F
-
D
T
L
T
T
E
K
-
G
G
----
I
H
P
K
E
A
A
E
H
H
A
R
L
M
K
P
L
L
R
K
A
L
S
E
A
G
V
S
L
D
D
I
D
V
I
A
F
S
Q
G
P
G
L
G
P
A
L
R
V
V
A
T
A
A
R
A
L
A
V
K
Y
R
K
P
I
V
G
V
N
H
C
I
A
H
V
E
I
T
K
---
M
----
F
G
---
V
K
D
-
P
V
G
L
Y
V
S
-
G
G
N
T
Q
V
L
-
A
L
E
-
G
G
R
Y
R
V
F
G
E
T
L
D
I
G
I
G
N
A
I
D
V
F
A
R
E
L
G
L
G
F
P
G
G
P
K
V
E
K
--------------
L
A
E
K
G
E
-
K
Y
-
I
E
L
P
Y
A
V
---
K
G
M
D
L
S
F
S
G
L
L
T
E
A
---
I
R
K
Y
R
-
S
-----
G
K
Y
R
V
-
E
D
L
A
Y
S
F
Q
E
T
A
F
A
A
L
V
E
V
-----
T
E
R
A
V
A
H
T
E
K
D
E
V
V
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
R
I
M
T
E
D
R
G
I
K
F
F
V
P
P
Y
D
L
C
R
D
N
G
A
M
I
A
Y
T
G
L
R
M
Y
K
A
G
I
S
F
R
L
E
E
T
I
V
-
K
Q
K
F
R
T
D
E
V
E
----
27
PsiBlast_CBE
83.38
32%
-105
- C5 -
2IVO
2
KAE1_PYRAB
B:
[1-301]
----
M
L
A
L
G
I
E
G
T
A
H
T
L
G
I
G
I
V
S
E
D
K
-
V
L
A
N
-
V
F
D
T
L
T
T
E
K
---
G
--
G
I
H
P
K
E
A
A
E
H
H
A
R
L
M
K
P
L
L
R
K
A
L
S
E
A
G
V
S
L
D
D
I
D
V
I
A
F
S
Q
G
P
G
L
G
P
A
L
R
V
V
A
T
A
A
R
A
L
A
V
K
Y
R
K
P
I
V
G
V
N
H
C
I
A
H
V
E
I
T
K
MFG
V
----
K
D
---
P
-----
V
G
L
Y
V
S
G
G
N
T
Q
V
L
-
A
L
E
G
G
-
R
Y
R
V
F
G
E
T
L
D
I
G
I
G
N
A
I
D
V
F
A
R
E
L
G
L
G
F
P
G
G
P
K
V
E
K
--------------
L
A
E
K
G
E
-
K
Y
-
I
E
L
P
Y
A
V
---
K
G
M
D
L
S
F
S
G
L
L
T
E
A
---
I
R
K
Y
R
-
S
G
K
Y
R
----
V
E
--
D
L
A
Y
S
F
Q
E
T
A
F
A
A
L
V
E
V
-----
T
E
R
A
V
A
H
T
E
K
D
E
V
V
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
R
I
M
T
E
D
R
G
I
K
F
F
V
P
P
Y
D
L
C
R
D
N
G
A
M
I
A
Y
T
G
L
R
M
Y
K
A
G
-------------------------
25
PsiBlast_CBE
83.12
32%
-107
- C5 -
2IVO
2
KAE1_PYRAB
D:
[1-301]
----
M
L
A
L
G
I
E
G
T
A
H
T
L
G
I
G
I
V
S
E
D
K
-
V
L
A
N
-
V
F
D
T
L
T
T
E
K
---
G
--
G
I
H
P
K
E
A
A
E
H
H
A
R
L
M
K
P
L
L
R
K
A
L
S
E
A
G
V
S
L
D
D
I
D
V
I
A
F
S
Q
G
P
G
L
G
P
A
L
R
V
V
A
T
A
A
R
A
L
A
V
K
Y
R
K
P
I
V
G
V
N
H
C
I
A
H
V
E
I
T
K
MFG
V
----
K
D
---
P
-----
V
G
L
Y
V
S
G
G
N
T
Q
V
L
-
A
L
E
G
G
-
R
Y
R
V
F
G
E
T
L
D
I
G
I
G
N
A
I
D
V
F
A
R
E
L
G
L
G
F
P
G
G
P
K
V
E
K
--------------
L
A
E
K
G
E
-
K
Y
-
I
E
L
P
Y
A
V
---
K
G
M
D
L
S
F
S
G
L
L
T
E
A
---
I
R
K
Y
R
-
S
G
K
Y
R
----
V
E
--
D
L
A
Y
S
F
Q
E
T
A
F
A
A
L
V
E
V
-----
T
E
R
A
V
A
H
T
E
K
D
E
V
V
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
R
I
M
T
E
D
R
G
I
K
F
F
V
P
P
Y
D
L
C
R
D
N
G
A
M
I
A
Y
T
G
L
R
M
Y
K
A
G
-------------------------
9
PsiBlast_PDB
80.70
29%
-97
- C5 -
3EN9
1
KAE1B_METJA
A:
[6-328]
----
M
I
C
L
G
L
E
G
T
A
E
K
T
G
V
G
I
V
T
S
D
G
E
V
L
F
N
K
T
I
M
Y
K
P
P
K
Q
------
G
I
N
P
R
E
A
A
D
H
H
A
E
T
F
P
K
L
I
K
E
A
F
E
V
V
D
K
N
--
E
I
D
L
I
A
F
S
Q
G
P
G
L
G
P
S
L
R
V
T
A
T
V
A
R
T
L
S
L
T
L
K
K
P
I
I
G
V
N
H
C
I
A
H
I
E
I
G
K
---
L
T
T
EA
E
D
---
P
L
T
-----
L
Y
V
S
G
G
N
T
Q
V
I
A
Y
V
S
K
--
K
Y
R
V
F
G
E
T
L
D
I
A
V
G
N
C
L
D
Q
F
A
R
Y
V
N
L
P
H
P
G
G
P
Y
I
E
E
--------------
L
A
R
K
G
K
-
K
L
-
V
D
L
P
Y
T
---
V
K
G
M
D
I
A
F
S
G
L
L
T
A
A
---
M
R
A
Y
D
A
G
E
R
L
E
D
I
--------
C
Y
S
L
Q
E
Y
A
F
S
M
L
T
E
I
-----
T
E
R
A
L
A
H
T
N
K
G
E
V
M
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
K
A
M
C
E
G
Q
N
V
D
F
Y
V
P
P
K
E
F
C
G
D
N
G
A
M
I
A
W
L
G
L
L
M
H
K
N
G
R
W
M
S
L
--------------------
10
PsiBlast_PDB
80.50
29%
-100
- C5 -
2VWB
1
KAE1B_METJA
A:
[1-305]
----
M
I
C
L
G
L
E
G
T
A
E
K
T
G
V
G
I
V
T
S
D
G
E
V
L
F
N
K
T
I
M
-----------------
E
A
A
D
H
H
A
E
T
F
P
K
L
I
K
E
A
F
E
V
V
D
K
N
--
E
I
D
L
I
A
F
S
Q
G
P
G
L
G
P
S
L
R
V
T
A
T
V
A
R
T
L
S
L
T
L
K
K
P
I
I
G
V
N
H
C
I
A
H
I
E
I
G
K
---
L
T
TEA
E
D
---
P
L
T
-----
L
Y
V
S
G
G
N
T
Q
V
I
A
Y
V
S
K
--
K
Y
R
V
F
G
E
T
L
D
I
A
V
G
N
C
L
D
Q
F
A
R
Y
V
N
L
P
H
P
G
G
P
Y
I
E
E
--------------
L
A
R
K
G
K
-
K
L
-
V
D
L
P
Y
T
---
V
K
G
M
D
I
A
F
S
G
L
L
T
A
A
---
M
R
A
Y
D
A
G
E
R
L
E
D
I
--------
C
Y
S
L
Q
E
Y
A
F
S
M
L
T
E
I
-----
T
E
R
A
L
A
H
T
N
K
G
E
V
M
L
V
G
G
V
A
A
N
N
R
L
R
E
M
L
K
A
M
C
E
G
Q
N
V
D
F
Y
V
P
P
K
E
F
C
G
D
N
G
A
M
I
A
W
L
G
L
L
M
H
K
N
G
R
W
M
S
L
--------------------
11
PsiBlast_PDB
79.79
30%
-96
- C5 -
3WUH
2
QRI7_YEAST
A:
[7-355]
--
K
G
Y
K
V
L
A
I
E
T
S
C
D
D
T
C
V
S
V
L
D
R
F
S
K
S
A
A
P
N
V
L
A
N
L
K
D
T
L
-
D
---------
K
A
H
I
H
H
Q
A
R
I
G
P
L
T
E
R
A
L
I
E
S
N
-
A
R
E
G
I
D
L
I
C
V
T
R
G
P
G
M
P
G
S
L
S
G
G
L
D
F
A
K
G
L
A
V
A
W
N
K
P
L
I
G
V
H
H
M
L
G
H
L
L
I
P
R
---
M
GTNG
K
V
---
P
-
Q
F
P
F
V
S
L
L
V
S
G
G
H
T
T
F
V
-
L
S
R
A
I
D
D
H
E
I
L
C
D
T
I
D
I
A
V
G
D
S
L
D
K
C
G
R
E
L
G
F
K
---
G
T
M
I
A
R
E
M
E
K
F
I
N
Q
D
INDQD
F
A
L
K
L
E
-
M
P
----------
R
N
M
L
S
F
S
F
S
A
F
I
T
A
L
R
T
N
L
T
K
L
G
-
K
T
-----
P
E
R
E
I
R
S
I
A
Y
Q
V
Q
E
S
V
F
D
H
I
I
N
K
L
K
H
V
L
K
S
Q
P
E
K
F
K
N
V
R
E
F
V
C
S
G
G
V
S
S
N
Q
R
L
R
T
K
L
E
T
E
L
----
F
N
F
Y
Y
P
P
M
D
L
C
S
D
N
S
I
M
I
G
W
A
G
I
E
I
W
E
S
L
R
L
-----------------------