@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA2129: (2016-04-01 )
MIVEVEHQRQGVDLIKIDNDETKIIFTNYGARVVSWKYHDNNIVLGNVVEADEFYHSNPFKFGASIGRYSGRIDNAKFKLKGKEYQLEKNNGEHHLHGGCHGLDNKLFDYEIRNEIAQIKVIFKTVLKSADDHFPGDIDVTITHIYDADHQWSIEYEAVASEDTLFSPMNHVYFNLNRDNNVVDNHRISSNQLDMYVLDERNIVTGDILDLHEVFEDNKIKLSDIFTSQHAQLSQQMTRFGGLDHPFTVGEHKMYVENHEFMLEVDTDMPHVVFFTFNQPDEWDSPFNIYKPHSGFTLETQFLPNDINLYGEKAPSILKAGEVFNSKTSFRIEEKVEND
Atome Classification :
(25 SA)
.........10........-20-........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......-180.....--...190.......-200.......210..---.....220........230.......240.......250------........260..-----.....270.......280...-....290--.......300.......310.....----..320.......330.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
I
V
E
V
E
HQRQG
V
D
L
I
K
IDN-DE-
T
K
I
I
F
TNYG
A
R
V
V
S
W
K
YHDN
N
I
V
L
GNVV
E
A
D
E
F
YHSNPFKFGASIGRYSGRIDN
A
K
F
K
LKG
K
E
Y
Q
L
EKNNGEHHLHGGCHGLDNK
L
F
D
Y
E
I
R
N
E
I
A
Q
I
K
V
I
F
K
T
V
L
K
SADDHFPGD
I
D
V
T
I
T
H
I
YDAD
H
Q
W
S
I
E
Y
E
AVASEDTLFSPM
N
H
V
Y
F
N
LNRD-N-NVVDNH--RISSNQL
D
M
Y
V
LD-ERNIVT
G
D
I
L
D
L
H
E
V
---FEDN
K
I
K
-
L
S
D
I
F
T
S
Q
H
A
Q
L
S
Q
Q
M
T
R
FGGLDHPFTVG
E
-------
H
K
M
Y
V
EN
H
E
F
M
L
E
-----VDTDM
P
H
V
V
F
F
TFNQPDEWDS-PFNIYKP--HSG
F
T
L
E
T
QFLPND
I
N
LYGEKA
P
S
I
----
L
K
A
G
E
VFNSKT
S
F
R
I
E
E
KVEND
1
PsiBlast_PDB
94.59
33%
-65
- C4 -
1L7J
-
?
A:
[2-339]
-
S
I
K
I
R
D
F
G
L
G
S
D
L
I
S
L
T
N
-
K
A
G
V
T
I
S
F
T
N
L
G
A
R
I
V
D
W
Q
K
D
G
K
H
L
I
L
G
-
F
D
S
A
K
E
Y
L
E
K
D
A
Y
P
-
G
A
T
V
G
P
T
A
G
R
I
K
D
G
L
V
K
I
S
G
K
D
Y
I
L
N
Q
N
E
G
P
Q
T
L
H
G
G
E
E
S
I
H
T
K
L
W
T
Y
E
V
T
D
L
G
A
E
V
Q
V
K
F
S
L
V
S
N
D
G
T
N
G
Y
P
G
K
I
E
M
S
V
T
H
S
F
D
D
D
N
K
W
K
I
H
Y
E
A
I
S
D
K
D
T
V
F
N
P
T
G
H
V
Y
F
N
L
N
G
D
A
S
-
E
S
V
E
N
H
G
L
R
L
A
A
S
R
F
-
V
P
L
K
D
-
Q
T
E
I
V
R
G
D
I
V
D
I
K
N
T
DLD
F
R
Q
E
K
-
Q
-
L
S
N
A
F
N
S
N
M
E
Q
V
--
Q
L
V
K
--
G
I
D
H
P
F
L
L
D
Q
-------
L
G
L
D
K
E
Q
A
R
L
T
L
D
D
T
S
I
S
V
F
T
D
Q
P
S
I
V
I
F
T
A
N
F
G
D
-
L
G
T
-
L
Y
H
E
K
K
Q
V
H
H
G
G
I
T
F
E
C
Q
V
S
P
G
S
-----
E
Q
I
P
E
L
GDIS
L
K
A
G
E
K
Y
Q
A
T
T
I
Y
S
L
H
T
K
----
23
PsiBlast_CBE
94.44
33%
-64
- C4 -
1MMY
2
?
B:
[2-341]
-
S
I
K
I
R
D
F
G
L
G
S
D
L
I
S
L
T
N
-
K
A
G
V
T
I
S
F
T
N
L
G
A
R
I
V
D
W
Q
K
D
G
K
H
L
I
L
G
-
F
D
S
A
K
E
Y
L
E
K
D
A
Y
P
-
G
A
T
V
G
P
T
A
G
R
I
K
D
G
L
V
K
I
S
G
K
D
Y
I
L
N
Q
N
E
G
P
Q
T
L
H
G
G
E
E
S
I
H
T
K
L
W
T
Y
E
V
T
D
L
G
A
E
V
Q
V
K
F
S
L
V
S
N
D
G
T
N
G
Y
P
G
K
I
E
M
S
V
T
H
S
F
D
D
D
N
K
W
K
I
H
Y
E
A
I
S
D
K
D
T
V
F
N
P
T
G
H
V
Y
F
N
L
N
G
D
A
S
-
E
S
V
E
N
H
GL
R
L
A
A
S
R
F
-
V
P
L
K
D
-
Q
T
E
I
V
R
G
D
I
V
D
I
K
N
T
DLD
F
R
Q
E
K
-
Q
-
L
S
N
A
F
N
S
N
M
E
Q
V
--
Q
L
V
K
--
G
I
D
H
P
F
L
L
D
Q
-------
L
G
L
D
K
E
Q
A
R
L
T
L
D
DTSIS
V
F
T
D
Q
P
S
I
V
I
F
T
A
N
F
G
D
-
L
G
T
-
L
Y
H
E
K
K
Q
VH
H
G
G
I
T
F
E
C
Q
V
S
P
G
S
-----
E
Q
I
P
E
L
GDIS
L
K
A
G
E
K
Y
Q
A
T
T
I
Y
S
L
H
T
K
L
E
--
37
PsiBlast_CBE
94.22
33%
-65
- C4 -
1NSS
2
?
B:
[2-341]
-
S
I
K
I
R
D
F
G
L
G
S
D
L
I
S
L
T
N
-
K
A
G
V
T
I
S
F
T
N
L
G
A
R
I
V
D
W
Q
K
D
G
K
H
L
I
L
G
-
F
D
S
A
K
E
Y
L
E
K
D
A
Y
P
-
G
A
T
V
G
P
T
A
G
R
I
K
D
G
L
V
K
I
S
G
K
D
Y
I
L
N
Q
N
E
G
P
Q
T
L
H
G
G
E
E
S
I
H
T
K
L
W
T
Y
E
V
T
D
L
G
A
E
V
Q
V
K
F
S
L
V
S
N
D
G
T
N
G
Y
P
G
K
I
E
M
S
V
T
H
S
F
D
D
D
N
K
W
K
I
H
Y
E
A
I
S
D
K
D
T
V
F
N
P
T
G
H
V
Y
F
N
L
N
G
D
A
S
-
E
S
V
E
N
H
GL
R
L
A
A
S
R
F
-
V
P
L
K
D
-
Q
T
E
I
V
R
G
D
I
V
D
I
K
N
T
DLD
F
R
Q
E
K
-
Q
-
L
S
N
A
F
N
S
N
M
E
Q
V
--
Q
L
V
K
--
G
I
A
H
P
F
L
L
D
Q
-------
L
G
L
D
K
E
Q
A
R
L
T
L
D
DTSIS
V
F
T
D
Q
P
S
I
V
I
F
T
A
N
F
G
D
-
L
G
T
-
L
Y
H
E
K
K
Q
VH
H
G
G
I
T
F
E
C
Q
V
S
P
G
S
-----
E
Q
I
P
E
L
GDIS
L
K
A
G
E
K
Y
Q
A
T
T
I
Y
S
L
H
T
K
L
E
--
22
PsiBlast_CBE
94.10
33%
-63
- C4 -
1MMZ
2
?
B:
[2-341]
-
S
I
K
I
R
D
F
G
L
G
S
D
L
I
S
L
T
N
-
K
A
G
V
T
I
S
F
T
N
L
G
A
R
I
V
D
W
Q
K
D
G
K
H
L
I
L
G
-
F
D
S
A
K
E
Y
L
E
K
D
A
Y
P
-
G
A
T
V
G
P
T
A
G
R
I
K
D
G
L
V
K
I
S
G
K
D
Y
I
L
N
Q
N
E
G
P
Q
T
L
H
G
G
E
E
S
I
H
T
K
L
W
T
Y
E
V
T
D
L
G
A
E
V
Q
V
K
F
S
L
V
S
N
D
G
T
N
G
Y
P
G
K
I
E
M
S
V
T
H
S
F
D
D
D
N
K
W
K
I
H
Y
E
A
I
S
D
K
D
T
V
F
N
P
T
G
H
V
Y
F
N
L
N
G
D
A
S
-
E
S
V
E
N
H
GL
R
L
A
A
S
R
F
-
V
P
L
K
D
-
Q
T
E
I
V
R
G
D
I
V
D
I
K
N
T
DLD
F
R
Q
E
K
-
Q
-
L
S
N
A
F
N
S
N
M
E
Q
V
--
Q
L
V
K
--
G
I
D
H
P
F
L
L
D
Q
-------
L
G
L
D
K
E
Q
A
R
L
T
L
D
DTSIS
V
F
T
D
Q
P
S
I
V
I
F
T
A
N
F
G
D
-
L
G
T
-
L
Y
H
E
K
K
Q
VH
H
G
G
I
T
F
E
C
Q
V
S
P
G
S
-----
E
Q
I
P
E
L
GDIS
L
K
A
G
E
K
Y
Q
A
T
T
I
Y
S
L
H
T
K
L
E
--
38
PsiBlast_CBE
93.90
33%
-63
- C4 -
1NSM
2
?
B:
[2-341]
-
S
I
K
I
R
D
F
G
L
G
S
D
L
I
S
L
T
N
-
K
A
G
V
T
I
S
F
T
N
L
G
A
R
I
V
D
W
Q
K
D
G
K
H
L
I
L
G
-
F
D
S
A
K
E
Y
L
E
K
D
A
Y
P
-
G
A
T
V
G
P
T
A
G
R
I
K
D
G
L
V
K
I
S
G
K
D
Y
I
L
N
Q
N
E
G
P
Q
T
L
H
G
G
E
E
S
I
H
T
K
L
W
T
Y
E
V
T
D
L
G
A
E
V
Q
V
K
F
S
L
V
S
N
D
G
T
N
G
Y
P
G
K
I
E
M
S
V
T
H
S
F
D
D
D
N
K
W
K
I
H
Y
E
A
I
S
D
K
D
T
V
F
N
P
T
G
H
V
Y
F
N
L
N
G
D
A
S
-
E
S
V
E
N
H
GL
R
L
A
A
S
R
F
-
V
P
L
K
D
-
Q
T
E
I
V
R
G
D
I
V
D
I
K
N
T
DLD
F
R
Q
E
K
-
Q
-
L
S
N
A
F
N
S
N
M
E
Q
V
--
Q
L
V
K
--
G
I
A
H
P
F
L
L
D
Q
-------
L
G
L
D
K
E
Q
A
R
L
T
L
D
DTSIS
V
F
T
D
Q
P
S
I
V
I
F
T
A
N
F
G
D
-
L
G
T
-
L
Y
H
E
K
K
Q
VH
H
G
G
I
T
F
E
C
Q
V
S
P
G
S
-----
E
Q
I
P
E
L
GDIS
L
K
A
G
E
K
Y
Q
A
T
T
I
Y
S
L
H
T
K
L
E
--
24
PsiBlast_CBE
93.75
33%
-64
- C4 -
1MMX
2
?
B:
[2-341]
-
S
I
K
I
R
D
F
G
L
G
S
D
L
I
S
L
T
N
-
K
A
G
V
T
I
S
F
T
N
L
G
A
R
I
V
D
W
Q
K
D
G
K
H
L
I
L
G
-
F
D
S
A
K
E
Y
L
E
K
D
A
Y
P
-
G
A
T
V
G
P
T
A
G
R
I
K
D
G
L
V
K
I
S
G
K
D
Y
I
L
N
Q
N
E
G
P
Q
T
L
H
G
G
E
E
S
I
H
T
K
L
W
T
Y
E
V
T
D
L
G
A
E
V
Q
V
K
F
S
L
V
S
N
D
G
T
N
G
Y
P
G
K
I
E
M
S
V
T
H
S
F
D
D
D
N
K
W
K
I
H
Y
E
A
I
S
D
K
D
T
V
F
N
P
T
G
H
V
Y
F
N
L
N
G
D
A
S
-
E
S
V
E
N
H
GL
R
L
A
A
S
R
F
-
V
P
L
K
D
-
Q
T
E
I
V
R
G
D
I
V
D
I
K
N
T
DLD
F
R
Q
E
K
-
Q
-
L
S
N
A
F
N
S
N
M
E
Q
V
--
Q
L
V
K
--
G
I
D
H
P
F
L
L
D
Q
-------
L
G
L
D
K
E
Q
A
R
L
T
L
D
DTSIS
V
F
T
D
Q
P
S
I
V
I
F
T
A
N
F
G
D
-
L
G
T
-
L
Y
H
E
K
K
Q
VH
H
G
G
I
T
F
E
C
Q
V
S
P
G
S
-----
E
Q
I
P
E
L
GDIS
L
K
A
G
E
K
Y
Q
A
T
T
I
Y
S
L
H
T
K
L
E
--
3
PsiBlast_PDB
93.71
33%
-65
- C4 -
1MMU
2
?
A:
[2-340]
-
S
I
K
I
R
D
F
G
L
G
S
D
L
I
S
L
T
N
-
K
A
G
V
T
I
S
F
T
N
L
G
A
R
I
V
D
W
Q
K
D
G
K
H
L
I
L
G
-
F
D
S
A
K
E
Y
L
E
K
D
A
Y
P
-
G
A
T
V
G
P
T
A
G
R
I
K
D
G
L
V
K
I
S
G
K
D
Y
I
L
N
Q
N
E
G
P
Q
T
L
H
G
G
E
E
S
I
H
T
K
L
W
T
Y
E
V
T
D
L
G
A
E
V
Q
V
K
F
S
L
V
S
N
D
G
T
N
G
Y
P
G
K
I
E
M
S
V
T
H
S
F
D
D
D
N
K
W
K
I
H
Y
E
A
I
S
D
K
D
T
V
F
N
P
T
G
H
V
Y
F
N
L
N
G
D
A
S
-
E
S
V
E
N
H
G
L
R
L
A
A
S
R
F
-
V
P
L
K
D
-
Q
T
E
I
V
R
G
D
I
V
D
I
K
N
T
DLD
F
R
Q
E
K
-
Q
-
L
S
N
A
F
N
S
N
M
E
Q
V
--
Q
L
V
K
--
G
I
D
H
P
F
L
L
D
Q
-------
L
G
L
D
K
E
Q
A
R
L
T
L
D
D
T
S
I
S
V
F
T
D
Q
P
S
I
V
I
F
T
A
N
F
G
D
-
L
G
T
-
L
Y
H
E
K
K
Q
VH
H
G
G
I
T
F
E
C
Q
V
S
P
G
S
-----
E
Q
I
P
E
L
GDIS
L
K
A
G
E
K
Y
Q
A
T
T
I
Y
S
L
H
T
K
L
---
15
PsiBlast_PDB
93.63
33%
-65
- C4 -
1NSV
2
?
A:
[2-340]
-
S
I
K
I
R
D
F
G
L
G
S
D
L
I
S
L
T
N
-
K
A
G
V
T
I
S
F
T
N
L
G
A
R
I
V
D
W
Q
K
D
G
K
H
L
I
L
G
-
F
D
S
A
K
E
Y
L
E
K
D
A
Y
P
-
G
A
T
V
G
P
T
A
G
R
I
K
D
G
L
V
K
I
S
G
K
D
Y
I
L
N
Q
N
E
G
P
Q
T
L
N
G
G
E
E
S
I
H
T
K
L
W
T
Y
E
V
T
D
L
G
A
E
V
Q
V
K
F
S
L
V
S
N
D
G
T
N
G
Y
P
G
K
I
E
M
S
V
T
H
S
F
D
D
D
N
K
W
K
I
H
Y
E
A
I
S
D
K
D
T
V
F
N
P
T
G
H
V
Y
F
N
L
N
G
D
A
S
-
E
S
V
E
N
H
G
L
R
L
A
A
S
R
F
-
V
P
L
K
D
-
Q
T
E
I
V
R
G
D
I
V
D
I
K
N
T
DLD
F
R
Q
E
K
-
Q
-
L
S
N
A
F
N
S
N
M
E
Q
V
--
Q
L
V
K
--
G
I
D
H
P
F
L
L
D
Q
-------
L
G
L
D
K
E
Q
A
R
L
T
L
D
D
T
S
I
S
V
F
T
D
Q
P
S
I
V
I
F
T
A
N
F
G
D
-
L
G
T
-
L
Y
H
E
K
K
Q
V
H
H
G
G
I
T
F
E
C
Q
V
S
P
G
S
-----
E
Q
I
P
E
L
GDIS
L
K
A
G
E
K
Y
Q
A
T
T
I
Y
S
L
H
T
K
L
---
33
PsiBlast_CBE
93.62
33%
-65
- C4 -
1NSZ
2
?
B:
[2-341]
-
S
I
K
I
R
D
F
G
L
G
S
D
L
I
S
L
T
N
-
K
A
G
V
T
I
S
F
T
N
L
G
A
R
I
V
D
W
Q
K
D
G
K
H
L
I
L
G
-
F
D
S
A
K
E
Y
L
E
K
D
A
Y
P
-
G
A
T
V
G
P
T
A
G
R
I
K
D
G
L
V
K
I
S
G
K
D
Y
I
L
N
Q
N
E
G
P
Q
T
L
H
G
G
E
E
S
I
H
T
K
L
W
T
Y
E
V
T
D
L
G
A
E
V
Q
V
K
F
S
L
V
S
N
D
G
T
N
G
Y
P
G
K
I
E
M
S
V
T
H
S
F
D
D
D
N
K
W
K
I
H
Y
E
A
I
S
D
K
D
T
V
F
N
P
T
G
N
V
Y
F
N
L
N
G
D
A
S
-
E
S
V
E
N
H
GL
R
L
A
A
S
R
F
-
V
P
L
K
D
-
Q
T
E
I
V
R
G
D
I
V
D
I
K
N
T
DLD
F
R
Q
E
K
-
Q
-
L
S
N
A
F
N
S
N
M
E
Q
V
--
Q
L
V
K
--
G
I
D
H
P
F
L
L
D
Q
-------
L
G
L
D
K
E
Q
A
R
L
T
L
D
DTSIS
V
F
T
D
Q
P
S
I
V
I
F
T
A
N
F
G
D
-
L
G
T
-
L
Y
H
E
K
K
Q
VH
H
G
G
I
T
F
E
C
Q
V
S
P
G
S
-----
E
Q
I
P
E
L
GDIS
L
K
A
G
E
K
Y
Q
A
T
T
I
Y
S
L
H
T
K
L
E
--
30
PsiBlast_CBE
93.59
33%
-65
- C4 -
1NS8
2
?
B:
[2-341]
-
S
I
K
I
R
D
F
G
L
G
S
D
L
I
S
L
T
N
-
K
A
G
V
T
I
S
F
T
N
L
G
A
R
I
V
D
W
Q
K
D
G
K
H
L
I
L
G
-
F
D
S
A
K
E
Y
L
E
K
D
A
Y
P
-
G
A
T
V
G
P
T
A
G
R
I
K
D
G
L
V
K
I
S
G
K
D
Y
I
L
N
Q
N
E
G
P
Q
T
L
H
G
G
E
E
S
I
H
T
K
L
W
T
Y
E
V
T
D
L
G
A
E
V
Q
V
K
F
S
L
V
S
N
D
G
T
N
G
Y
P
G
K
I
E
M
S
V
T
H
S
F
D
D
D
N
K
W
K
I
H
Y
E
A
I
S
D
K
D
T
V
F
N
P
T
G
H
V
Y
F
N
L
N
G
D
A
S
-
E
S
V
E
N
H
GL
R
L
A
A
S
R
F
-
V
P
L
K
D
-
Q
T
E
I
V
R
G
D
I
V
D
I
K
N
T
DLD
F
R
Q
E
K
-
Q
-
L
S
N
A
F
N
S
N
M
E
Q
V
--
Q
L
V
K
--
G
I
N
H
P
F
L
L
D
Q
-------
L
G
L
D
K
E
Q
A
R
L
T
L
D
DTSIS
V
F
T
D
Q
P
S
I
V
I
F
T
A
N
F
G
D
-
L
G
T
-
L
Y
H
E
K
K
Q
VH
H
G
G
I
T
F
E
C
Q
V
S
P
G
S
-----
E
Q
I
P
E
L
GDIS
L
K
A
G
E
K
Y
Q
A
T
T
I
Y
S
L
H
T
K
L
E
--
34
PsiBlast_CBE
93.56
33%
-62
- C4 -
1NSX
2
?
B:
[2-341]
-
S
I
K
I
R
D
F
G
L
G
S
D
L
I
S
L
T
N
-
K
A
G
V
T
I
S
F
T
N
L
G
A
R
I
V
D
W
Q
K
D
G
K
H
L
I
L
G
-
F
D
S
A
K
E
Y
L
E
K
D
A
Y
P
-
G
A
T
V
G
P
T
A
G
R
I
K
D
G
L
V
K
I
S
G
K
D
Y
I
L
N
Q
N
E
G
P
Q
T
L
H
G
G
E
E
S
I
H
T
K
L
W
T
Y
E
V
T
D
L
G
A
E
V
Q
V
K
F
S
L
V
S
N
D
G
T
N
G
Y
P
G
K
I
E
M
S
V
T
H
S
F
D
D
D
N
K
W
K
I
H
Y
E
A
I
S
D
K
D
T
V
F
N
P
T
G
N
V
Y
F
N
L
N
G
D
A
S
-
E
S
V
E
N
H
GL
R
L
A
A
S
R
F
-
V
P
L
K
D
-
Q
T
E
I
V
R
G
D
I
V
D
I
K
N
T
DLD
F
R
Q
E
K
-
Q
-
L
S
N
A
F
N
S
N
M
E
Q
V
--
Q
L
V
K
--
G
I
D
H
P
F
L
L
D
Q
-------
L
G
L
D
K
E
Q
A
R
L
T
L
D
DTSIS
V
F
T
D
Q
P
S
I
V
I
F
T
A
N
F
G
D
-
L
G
T
-
L
Y
H
E
K
K
Q
VH
H
G
G
I
T
F
E
C
Q
V
S
P
G
S
-----
E
Q
I
P
E
L
GDIS
L
K
A
G
E
K
Y
Q
A
T
T
I
Y
S
L
H
T
K
L
E
--
35
PsiBlast_CBE
93.52
33%
-66
- C4 -
1NSV
2
?
B:
[2-341]
-
S
I
K
I
R
D
F
G
L
G
S
D
L
I
S
L
T
N
-
K
A
G
V
T
I
S
F
T
N
L
G
A
R
I
V
D
W
Q
K
D
G
K
H
L
I
L
G
-
F
D
S
A
K
E
Y
L
E
K
D
A
Y
P
-
G
A
T
V
G
P
T
A
G
R
I
K
D
G
L
V
K
I
S
G
K
D
Y
I
L
N
Q
N
E
G
P
Q
T
L
N
G
G
E
E
S
I
H
T
K
L
W
T
Y
E
V
T
D
L
G
A
E
V
Q
V
K
F
S
L
V
S
N
D
G
T
N
G
Y
P
G
K
I
E
M
S
V
T
H
S
F
D
D
D
N
K
W
K
I
H
Y
E
A
I
S
D
K
D
T
V
F
N
P
T
G
H
V
Y
F
N
L
N
G
D
A
S
-
E
S
V
E
N
H
GL
R
L
A
A
S
R
F
-
V
P
L
K
D
-
Q
T
E
I
V
R
G
D
I
V
D
I
K
N
T
DLD
F
R
Q
E
K
-
Q
-
L
S
N
A
F
N
S
N
M
E
Q
V
--
Q
L
V
K
--
G
I
D
H
P
F
L
L
D
Q
-------
L
G
L
D
K
E
Q
A
R
L
T
L
D
DTSIS
V
F
T
D
Q
P
S
I
V
I
F
T
A
N
F
G
D
-
L
G
T
-
L
Y
H
E
K
K
Q
VH
H
G
G
I
T
F
E
C
Q
V
S
P
G
S
-----
E
Q
I
P
E
L
GDIS
L
K
A
G
E
K
Y
Q
A
T
T
I
Y
S
L
H
T
K
L
E
--
26
PsiBlast_CBE
93.46
33%
-64
- C4 -
1L7K
2
?
B:
[2-341]
-
S
I
K
I
R
D
F
G
L
G
S
D
L
I
S
L
T
N
-
K
A
G
V
T
I
S
F
T
N
L
G
A
R
I
V
D
W
Q
K
D
G
K
H
L
I
L
G
-
F
D
S
A
K
E
Y
L
E
K
D
A
Y
P
-
G
A
T
V
G
P
T
A
G
R
I
K
D
G
L
V
K
I
S
G
K
D
Y
I
L
N
Q
N
E
G
P
Q
T
L
H
G
G
E
E
S
I
H
T
K
L
W
T
Y
E
V
T
D
L
G
A
E
V
Q
V
K
F
S
L
V
S
N
D
G
T
N
G
Y
P
G
K
I
E
M
S
V
T
H
S
F
D
D
D
N
K
W
K
I
H
Y
E
A
I
S
D
K
D
T
V
F
N
P
T
G
H
V
Y
F
N
L
N
G
D
A
S
-
E
S
V
E
N
H
GL
R
L
A
A
S
R
F
-
V
P
L
K
D
-
Q
T
E
I
V
R
G
D
I
V
D
I
K
N
T
DLD
F
R
Q
E
K
-
Q
-
L
S
N
A
F
N
S
N
M
E
Q
V
--
Q
L
V
K
--
G
I
D
H
P
F
L
L
D
Q
-------
L
G
L
D
K
E
Q
A
R
L
T
L
D
DTSIS
V
F
T
D
Q
P
S
I
V
I
F
T
A
N
F
G
D
-
L
G
T
-
L
Y
H
E
K
K
Q
VH
H
G
G
I
T
F
E
C
Q
V
S
P
G
S
-----
E
Q
I
P
E
L
GDIS
L
K
A
G
E
K
Y
Q
A
T
T
I
Y
S
L
H
T
K
L
E
--
6
PsiBlast_PDB
93.45
33%
-65
- C4 -
1MMZ
2
?
A:
[2-340]
-
S
I
K
I
R
D
F
G
L
G
S
D
L
I
S
L
T
N
-
K
A
G
V
T
I
S
F
T
N
L
G
A
R
I
V
D
W
Q
K
D
G
K
H
L
I
L
G
-
F
D
S
A
K
E
Y
L
E
K
D
A
Y
P
-
G
A
T
V
G
P
T
A
G
R
I
K
D
G
L
V
K
I
S
G
K
D
Y
I
L
N
Q
N
E
G
P
Q
T
L
H
G
G
E
E
S
I
H
T
K
L
W
T
Y
E
V
T
D
L
G
A
E
V
Q
V
K
F
S
L
V
S
N
D
G
T
N
G
Y
P
G
K
I
E
M
S
V
T
H
S
F
D
D
D
N
K
W
K
I
H
Y
E
A
I
S
D
K
D
T
V
F
N
P
T
G
H
V
Y
F
N
L
N
G
D
A
S
-
E
S
V
E
N
H
G
L
R
L
A
A
S
R
F
-
V
P
L
K
D
-
Q
T
E
I
V
R
G
D
I
V
D
I
K
N
T
DLD
F
R
Q
E
K
-
Q
-
L
S
N
A
F
N
S
N
M
E
Q
V
--
Q
L
V
K
--
G
I
D
H
P
F
L
L
D
Q
-------
L
G
L
D
K
E
Q
A
R
L
T
L
D
D
T
S
I
S
V
F
T
D
Q
P
S
I
V
I
F
T
A
N
F
G
D
-
L
G
T
-
L
Y
H
E
K
K
Q
V
H
H
G
G
I
T
F
E
C
Q
V
S
P
G
S
-----
E
Q
I
P
E
L
GDIS
L
K
A
G
E
K
Y
Q
A
T
T
I
Y
S
L
H
T
K
L
---
25
PsiBlast_CBE
93.41
33%
-64
- C4 -
1MMU
2
?
B:
[2-341]
-
S
I
K
I
R
D
F
G
L
G
S
D
L
I
S
L
T
N
-
K
A
G
V
T
I
S
F
T
N
L
G
A
R
I
V
D
W
Q
K
D
G
K
H
L
I
L
G
-
F
D
S
A
K
E
Y
L
E
K
D
A
Y
P
-
G
A
T
V
G
P
T
A
G
R
I
K
D
G
L
V
K
I
S
G
K
D
Y
I
L
N
Q
N
E
G
P
Q
T
L
H
G
G
E
E
S
I
H
T
K
L
W
T
Y
E
V
T
D
L
G
A
E
V
Q
V
K
F
S
L
V
S
N
D
G
T
N
G
Y
P
G
K
I
E
M
S
V
T
H
S
F
D
D
D
N
K
W
K
I
H
Y
E
A
I
S
D
K
D
T
V
F
N
P
T
G
H
V
Y
F
N
L
N
G
D
A
S
-
E
S
V
E
N
H
GL
R
L
A
A
S
R
F
-
V
P
L
K
D
-
Q
T
E
I
V
R
G
D
I
V
D
I
K
N
T
DLD
F
R
Q
E
K
-
Q
-
L
S
N
A
F
N
S
N
M
E
Q
V
--
Q
L
V
K
--
G
I
D
H
P
F
L
L
D
Q
-------
L
G
L
D
K
E
Q
A
R
L
T
L
D
DTSIS
V
F
T
D
Q
P
S
I
V
I
F
T
A
N
F
G
D
-
L
G
T
-
L
Y
H
E
K
K
Q
VH
H
G
G
I
T
F
E
C
Q
V
S
P
G
S
-----
E
Q
I
P
E
L
GDIS
L
K
A
G
E
K
Y
Q
A
T
T
I
Y
S
L
H
T
K
L
E
--
21
PsiBlast_CBE
93.39
33%
-61
- C4 -
1MN0
2
?
B:
[2-341]
-
S
I
K
I
R
D
F
G
L
G
S
D
L
I
S
L
T
N
-
K
A
G
V
T
I
S
F
T
N
L
G
A
R
I
V
D
W
Q
K
D
G
K
H
L
I
L
G
-
F
D
S
A
K
E
Y
L
E
K
D
A
Y
P
-
G
A
T
V
G
P
T
A
G
R
I
K
D
G
L
V
K
I
S
G
K
D
Y
I
L
N
Q
N
E
G
P
Q
T
L
H
G
G
E
E
S
I
H
T
K
L
W
T
Y
E
V
T
D
L
G
A
E
V
Q
V
K
F
S
L
V
S
N
D
G
T
N
G
Y
P
G
K
I
E
M
S
V
T
H
S
F
D
D
D
N
K
W
K
I
H
Y
E
A
I
S
D
K
D
T
V
F
N
P
T
G
H
V
Y
F
N
L
N
G
D
A
S
-
E
S
V
E
N
H
GL
R
L
A
A
S
R
F
-
V
P
L
K
D
-
Q
T
E
I
V
R
G
D
I
V
D
I
K
N
T
DLD
F
R
Q
E
K
-
Q
-
L
S
N
A
F
N
S
N
M
E
Q
V
--
Q
L
V
K
--
G
I
D
H
P
F
L
L
D
Q
-------
L
G
L
D
K
E
Q
A
R
L
T
L
D
DTSIS
V
F
T
D
Q
P
S
I
V
I
F
T
A
N
F
G
D
-
L
G
T
-
L
Y
H
E
K
K
Q
VH
H
G
G
I
T
F
E
C
Q
V
S
P
G
S
-----
E
Q
I
P
E
L
GDIS
L
K
A
G
E
K
Y
Q
A
T
T
I
Y
S
L
H
T
K
L
E
--
17
PsiBlast_PDB
93.26
33%
-63
- C4 -
1NSZ
2
?
A:
[2-341]
-
S
I
K
I
R
D
F
G
L
G
S
D
L
I
S
L
T
N
-
K
A
G
V
T
I
S
F
T
N
L
G
A
R
I
V
D
W
Q
K
D
G
K
H
L
I
L
G
-
F
D
S
A
K
E
Y
L
E
K
D
A
Y
P
-
G
A
T
V
G
P
T
A
G
R
I
K
D
G
L
V
K
I
S
G
K
D
Y
I
L
N
Q
N
E
G
P
Q
T
L
H
G
G
E
E
S
I
H
T
K
L
W
T
Y
E
V
T
D
L
G
A
E
V
Q
V
K
F
S
L
V
S
N
D
G
T
N
G
Y
P
G
K
I
E
M
S
V
T
H
S
F
D
D
D
N
K
W
K
I
H
Y
E
A
I
S
D
K
D
T
V
F
N
P
T
G
N
V
Y
F
N
L
N
G
D
A
S
-
E
S
V
E
N
H
G
L
R
L
A
A
S
R
F
-
V
P
L
K
D
-
Q
T
E
I
V
R
G
D
I
V
D
I
K
N
T
DLD
F
R
Q
E
K
-
Q
-
L
S
N
A
F
N
S
N
M
E
Q
V
--
Q
L
V
K
--
G
I
D
H
P
F
L
L
D
Q
-------
L
G
L
D
K
E
Q
A
R
L
T
L
D
D
T
S
I
S
V
F
T
D
Q
P
S
I
V
I
F
T
A
N
F
G
D
-
L
G
T
-
L
Y
H
E
K
K
Q
V
H
H
G
G
I
T
F
E
C
Q
V
S
P
G
S
-----
E
Q
I
P
E
L
GDIS
L
K
A
G
E
K
Y
Q
A
T
T
I
Y
S
L
H
T
K
L
E
--
36
PsiBlast_CBE
93.25
33%
-65
- C4 -
1NSU
2
?
B:
[2-341]
-
S
I
K
I
R
D
F
G
L
G
S
D
L
I
S
L
T
N
-
K
A
G
V
T
I
S
F
T
N
L
G
A
R
I
V
D
W
Q
K
D
G
K
H
L
I
L
G
-
F
D
S
A
K
E
Y
L
E
K
D
A
Y
P
-
G
A
T
V
G
P
T
A
G
R
I
K
D
G
L
V
K
I
S
G
K
D
Y
I
L
N
Q
N
E
G
P
Q
T
L
N
G
G
E
E
S
I
H
T
K
L
W
T
Y
E
V
T
D
L
G
A
E
V
Q
V
K
F
S
L
V
S
N
D
G
T
N
G
Y
P
G
K
I
E
M
S
V
T
H
S
F
D
D
D
N
K
W
K
I
H
Y
E
A
I
S
D
K
D
T
V
F
N
P
T
G
H
V
Y
F
N
L
N
G
D
A
S
-
E
S
V
E
N
H
GL
R
L
A
A
S
R
F
-
V
P
L
K
D
-
Q
T
E
I
V
R
G
D
I
V
D
I
K
N
T
DLD
F
R
Q
E
K
-
Q
-
L
S
N
A
F
N
S
N
M
E
Q
V
--
Q
L
V
K
--
G
I
D
H
P
F
L
L
D
Q
-------
L
G
L
D
K
E
Q
A
R
L
T
L
D
DTSIS
V
F
T
D
Q
P
S
I
V
I
F
T
A
N
F
G
D
-
L
G
T
-
L
Y
H
E
K
K
Q
VH
H
G
G
I
T
F
E
C
Q
V
S
P
G
S
-----
E
Q
I
P
E
L
GDIS
L
K
A
G
E
K
Y
Q
A
T
T
I
Y
S
L
H
T
K
L
E
--
29
PsiBlast_CBE
93.22
33%
-64
- C4 -
1NSR
2
?
B:
[2-341]
-
S
I
K
I
R
D
F
G
L
G
S
D
L
I
S
L
T
N
-
K
A
G
V
T
I
S
F
T
N
L
G
A
R
I
V
D
W
Q
K
D
G
K
H
L
I
L
G
-
F
D
S
A
K
E
Y
L
E
K
D
A
Y
P
-
G
A
T
V
G
P
T
A
G
R
I
K
D
G
L
V
K
I
S
G
K
D
Y
I
L
N
Q
N
E
G
P
Q
T
L
H
G
G
E
E
S
I
H
T
K
L
W
T
Y
E
V
T
D
L
G
A
E
V
Q
V
K
F
S
L
V
S
N
D
G
T
N
G
Y
P
G
K
I
E
M
S
V
T
H
S
F
D
D
D
N
K
W
K
I
H
Y
E
A
I
S
D
K
D
T
V
F
N
P
T
G
H
V
Y
F
N
L
N
G
D
A
S
-
E
S
V
E
N
H
GL
R
L
A
A
S
R
F
-
V
P
L
K
D
-
Q
T
E
I
V
R
G
D
I
V
D
I
K
N
T
DLD
F
R
Q
E
K
-
Q
-
L
S
N
A
F
N
S
N
M
E
Q
V
--
Q
L
V
K
--
G
I
N
H
P
F
L
L
D
Q
-------
L
G
L
D
K
E
Q
A
R
L
T
L
D
DTSIS
V
F
T
D
Q
P
S
I
V
I
F
T
A
N
F
G
D
-
L
G
T
-
L
Y
H
E
K
K
Q
VH
H
G
G
I
T
F
E
C
Q
V
S
P
G
S
-----
E
Q
I
P
E
L
GDIS
L
K
A
G
E
K
Y
Q
A
T
T
I
Y
S
L
H
T
K
L
E
--
19
PsiBlast_PDB
93.07
33%
-66
- C4 -
1NSS
2
?
A:
[2-340]
-
S
I
K
I
R
D
F
G
L
G
S
D
L
I
S
L
T
N
-
K
A
G
V
T
I
S
F
T
N
L
G
A
R
I
V
D
W
Q
K
D
G
K
H
L
I
L
G
-
F
D
S
A
K
E
Y
L
E
K
D
A
Y
P
-
G
A
T
V
G
P
T
A
G
R
I
K
D
G
L
V
K
I
S
G
K
D
Y
I
L
N
Q
N
E
G
P
Q
T
L
H
G
G
E
E
S
I
H
T
K
L
W
T
Y
E
V
T
D
L
G
A
E
V
Q
V
K
F
S
L
V
S
N
D
G
T
N
G
Y
P
G
K
I
E
M
S
V
T
H
S
F
D
D
D
N
K
W
K
I
H
Y
E
A
I
S
D
K
D
T
V
F
N
P
T
G
H
V
Y
F
N
L
N
G
D
A
S
-
E
S
V
E
N
H
G
L
R
L
A
A
S
R
F
-
V
P
L
K
D
-
Q
T
E
I
V
R
G
D
I
V
D
I
K
N
T
DLD
F
R
Q
E
K
-
Q
-
L
S
N
A
F
N
S
N
M
E
Q
V
--
Q
L
V
K
--
G
I
A
H
P
F
L
L
D
Q
-------
L
G
L
D
K
E
Q
A
R
L
T
L
D
D
T
S
I
S
V
F
T
D
Q
P
S
I
V
I
F
T
A
N
F
G
D
-
L
G
T
-
L
Y
H
E
K
K
Q
V
H
H
G
G
I
T
F
E
C
Q
V
S
P
G
S
-----
E
Q
I
P
E
L
GDIS
L
K
A
G
E
K
Y
Q
A
T
T
I
Y
S
L
H
T
K
L
---
7
PsiBlast_PDB
92.94
33%
-63
- C4 -
1MN0
2
?
A:
[2-340]
-
S
I
K
I
R
D
F
G
L
G
S
D
L
I
S
L
T
N
-
K
A
G
V
T
I
S
F
T
N
L
G
A
R
I
V
D
W
Q
K
D
G
K
H
L
I
L
G
-
F
D
S
A
K
E
Y
L
E
K
D
A
Y
P
-
G
A
T
V
G
P
T
A
G
R
I
K
D
G
L
V
K
I
S
G
K
D
Y
I
L
N
Q
N
E
G
P
Q
T
L
H
G
G
E
E
S
I
H
T
K
L
W
T
Y
E
V
T
D
L
G
A
E
V
Q
V
K
F
S
L
V
S
N
D
G
T
N
G
Y
P
G
K
I
E
M
S
V
T
H
S
F
D
D
D
N
K
W
K
I
H
Y
E
A
I
S
D
K
D
T
V
F
N
P
T
G
H
V
Y
F
N
L
N
G
D
A
S
-
E
S
V
E
N
H
G
L
R
L
A
A
S
R
F
-
V
P
L
K
D
-
Q
T
E
I
V
R
G
D
I
V
D
I
K
N
T
DLD
F
R
Q
E
K
-
Q
-
L
S
N
A
F
N
S
N
M
E
Q
V
--
Q
L
V
K
--
G
I
D
H
P
F
L
L
D
Q
-------
L
G
L
D
K
E
Q
A
R
L
T
L
D
D
T
S
I
S
V
F
T
D
Q
P
S
I
V
I
F
T
A
N
F
G
D
-
L
G
T
-
L
Y
H
E
K
K
Q
V
H
H
G
G
I
T
F
E
C
Q
V
S
P
G
S
-----
E
Q
I
P
E
L
GDIS
L
K
A
G
E
K
Y
Q
A
T
T
I
Y
S
L
H
T
K
L
---
2
PsiBlast_PDB
92.54
33%
-67
- C4 -
1L7K
2
?
A:
[2-340]
-
S
I
K
I
R
D
F
G
L
G
S
D
L
I
S
L
T
N
-
K
A
G
V
T
I
S
F
T
N
L
G
A
R
I
V
D
W
Q
K
D
G
K
H
L
I
L
G
-
F
D
S
A
K
E
Y
L
E
K
D
A
Y
P
-
G
A
T
V
G
P
T
A
G
R
I
K
D
G
L
V
K
I
S
G
K
D
Y
I
L
N
Q
N
E
G
P
Q
T
L
H
G
G
E
E
S
I
H
T
K
L
W
T
Y
E
V
T
D
L
G
A
E
V
Q
V
K
F
S
L
V
S
N
D
G
T
N
G
Y
P
G
K
I
E
M
S
V
T
H
S
F
D
D
D
N
K
W
K
I
H
Y
E
A
I
S
D
K
D
T
V
F
N
P
T
G
H
V
Y
F
N
L
N
G
D
A
S
-
E
S
V
E
N
H
G
L
R
L
A
A
S
R
F
-
V
P
L
K
D
-
Q
T
E
I
V
R
G
D
I
V
D
I
K
N
T
DLD
F
R
Q
E
K
-
Q
-
L
S
N
A
F
N
S
N
M
E
Q
V
--
Q
L
V
K
--
G
I
D
H
P
F
L
L
D
Q
-------
L
G
L
D
K
E
Q
A
R
L
T
L
D
D
T
S
I
S
V
F
T
D
Q
P
S
I
V
I
F
T
A
N
F
G
D
-
L
G
T
-
L
Y
H
E
K
K
Q
V
H
H
G
G
I
T
F
E
C
Q
V
S
P
G
S
-----
E
Q
I
P
E
L
GDIS
L
K
A
G
E
K
Y
Q
A
T
T
I
Y
S
L
H
T
K
L
---
4
PsiBlast_PDB
92.08
33%
-63
- C4 -
1MMX
2
?
A:
[2-340]
-
S
I
K
I
R
D
F
G
L
G
S
D
L
I
S
L
T
N
-
K
A
G
V
T
I
S
F
T
N
L
G
A
R
I
V
D
W
Q
K
D
G
K
H
L
I
L
G
-
F
D
S
A
K
E
Y
L
E
K
D
A
Y
P
-
G
A
T
V
G
P
T
A
G
R
I
K
D
G
L
V
K
I
S
G
K
D
Y
I
L
N
Q
N
E
G
P
Q
T
L
H
G
G
E
E
S
I
H
T
K
L
W
T
Y
E
V
T
D
L
G
A
E
V
Q
V
K
F
S
L
V
S
N
D
G
T
N
G
Y
P
G
K
I
E
M
S
V
T
H
S
F
D
D
D
N
K
W
K
I
H
Y
E
A
I
S
D
K
D
T
V
F
N
P
T
G
H
V
Y
F
N
L
N
G
D
A
S
-
E
S
V
E
N
H
G
L
R
L
A
A
S
R
F
-
V
P
L
K
D
-
Q
T
E
I
V
R
G
D
I
V
D
I
K
N
T
DLD
F
R
Q
E
K
-
Q
-
L
S
N
A
F
N
S
N
M
E
Q
V
--
Q
L
V
K
--
G
I
D
H
P
F
L
L
D
Q
-------
L
G
L
D
K
E
Q
A
R
L
T
L
D
D
T
S
I
S
V
F
T
D
Q
P
S
I
V
I
F
T
A
N
F
G
D
-
L
G
T
-
L
Y
H
E
K
K
Q
V
H
H
G
G
I
T
F
E
C
Q
V
S
P
G
S
-----
E
Q
I
P
E
L
GDIS
L
K
A
G
E
K
Y
Q
A
T
T
I
Y
S
L
H
T
K
L
---
5
PsiBlast_PDB
91.92
33%
-65
- C4 -
1MMY
2
?
A:
[2-340]
-
S
I
K
I
R
D
F
G
L
G
S
D
L
I
S
L
T
N
-
K
A
G
V
T
I
S
F
T
N
L
G
A
R
I
V
D
W
Q
K
D
G
K
H
L
I
L
G
-
F
D
S
A
K
E
Y
L
E
K
D
A
Y
P
-
G
A
T
V
G
P
T
A
G
R
I
K
D
G
L
V
K
I
S
G
K
D
Y
I
L
N
Q
N
E
G
P
Q
T
L
H
G
G
E
E
S
I
H
T
K
L
W
T
Y
E
V
T
D
L
G
A
E
V
Q
V
K
F
S
L
V
S
N
D
G
T
N
G
Y
P
G
K
I
E
M
S
V
T
H
S
F
D
D
D
N
K
W
K
I
H
Y
E
A
I
S
D
K
D
T
V
F
N
P
T
G
H
V
Y
F
N
L
N
G
D
A
S
-
E
S
V
E
N
H
G
L
R
L
A
A
S
R
F
-
V
P
L
K
D
-
Q
T
E
I
V
R
G
D
I
V
D
I
K
N
T
DLD
F
R
Q
E
K
-
Q
-
L
S
N
A
F
N
S
N
M
E
Q
V
--
Q
L
V
K
--
G
I
D
H
P
F
L
L
D
Q
-------
L
G
L
D
K
E
Q
A
R
L
T
L
D
D
T
S
I
S
V
F
T
D
Q
P
S
I
V
I
F
T
A
N
F
G
D
-
L
G
T
-
L
Y
H
E
K
K
Q
V
H
H
G
G
I
T
F
E
C
Q
V
S
P
G
S
-----
E
Q
I
P
E
L
GDIS
L
K
A
G
E
K
Y
Q
A
T
T
I
Y
S
L
H
T
K
L
---
51
HHSearch
91.03
34%
-64
* C4 *
1NSX
2
?
A:
[3-340]
--
I
K
I
R
D
F
G
L
G
S
D
L
I
S
L
T
N
K
A
G
-
V
T
I
S
F
T
N
L
G
A
R
I
V
D
W
Q
K
D
G
K
H
L
I
L
G
F
D
-
S
A
K
E
Y
L
E
K
-
D
A
Y
P
G
A
T
V
G
P
T
A
G
R
I
K
D
G
L
V
K
I
S
G
K
D
Y
I
L
N
Q
N
E
G
P
Q
T
L
H
G
G
E
E
S
I
H
T
K
L
W
T
Y
E
V
T
D
L
G
A
E
V
Q
V
K
F
S
L
V
S
N
D
G
T
N
G
Y
P
G
K
I
E
M
S
V
T
H
S
F
D
D
D
N
K
W
K
I
H
Y
E
A
I
S
D
K
D
T
V
F
N
P
T
G
N
V
Y
F
N
L
N
G
D
-
A
S
E
S
V
E
N
H
--
G
L
R
L
A
A
S
R
F
V
P
L
K
D
Q
T
E
I
V
R
G
D
I
V
D
I
K
N
T
D--
L
D
F
R
Q
E
K
Q
L
S
N
A
F
N
S
N
M
E
Q
V
Q
---
L
V
-
K
G
I
D
H
P
F
L
L
D
Q
LGLDKEQ
A
R
L
T
L
D
--
D
T
S
I
S
-----
V
F
T
D
Q
P
S
I
V
I
F
T
A
N
F
G
D
L
G
T
L
Y
H
E
K
K
Q
V
H
--
H
G
G
I
T
F
E
C
Q
V
S
P
G
S
E
Q
I
P
E
L
G
-
D
I
S
----
L
K
A
G
E
K
Y
Q
A
T
T
I
Y
S
L
H
T
K
L
---