@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0106: (2015-12-12 )
MNIYQKNLQALFKKDPLLFAKLKAIKENKKYEVFLGNDSANFNLLDKETNTPLFEKSPLDSSLELYKNSEIHMLYPYLYYFGLGNGVFYRLLLGNENLKRLVVIEPEIEVIFIVLNLLDFSTEILENRLILLHASFCNYNMIASLFDMDKKSRLYARMYDLKLFNAYYERYSHQMIEINQHFTRALEHGAISVGNDAKDALIGIKQHVANLPEVIKSPSLVDFVNALKNRDTAIIVSTGPSLNKQLPLLKEIAPYATLFCIDASFPILARAGIKPDIVLSLERVDLTAKFYEETPLDFQEGVIFALTSIVHKRLIQAIQKGVKQFSFRPFGYTNLFDLHQYGYVGIGMSAANMAYELVVHSRFKRCVFIGQDLSFSQSGNSHASGAIYGDREIKPKKDKDKIFIEKYGGNGKVETTLVWKLFLEFFEKDIFNTPYKLEVINATEGGARIKGTKEMPFKEVCEKIDKSKPKPPINLIYPTQSEQAKNLKIAKKKCEEIIKYANEKKTQVEEAFLKVAEFLEKVEKLHEKNKLEELDFEELENLSAEIDNVKELFDDKRFNSYFMDAIQSYIFHQELHIAEIVCKKTSNEDGLRAKQLEYIYAHKYWLFSLAGGMDCVIEAIKMALKEW
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120-.-.......130.......140.......150.......160.......170.......180.......190.......-----------200.......210.......220.....---------..230--.--.......240...-....250-.......260.......270.......280.....--.--.290.......300.....-..310-----.....------...320--........330.---.---.--.--..--.-.340.......350.......360.......370.......380.......390.......400.......410.--.......420.......430.......440.......450.......460.......470.......480.......490.......500-----........510.....-..520....-----...530.--......540.......-550.......560.......570.......580.......590.......600.......610.......620.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MN
I
Y
Q
K
N
L
Q
A
L
F
KKD
P
L
L
F
A
K
L
K
A
I
KENK
K
Y
E
V
F
LGNDSAN
F
N
L
LDKETNTPLFEKSPL
D
S
S
L
E
L
YKNS
E
I
H
M
L
Y
P
Y
L
Y
Y
FGLGNG
V
F
Y
R
L
L
LGNEN
L
K
R
L
V
V
IEPE
I
E
V
I
F
I
V
L
N
L
L
D
F
S
--
T
-
E
I
L
EN
R
L
I
L
L
H
ASFCN
Y
N
M
I
A
S
L
FDM
D
K
K
S
R
L
Y
A
R
M
Y
D
L
K
L
F
N
A
Y
Y
E
R
Y
S
H
Q
M
I
E
I
N
Q
H
F
T
R
A
L
EHG
A
I
SVGND
A
K
D
-----------
A
L
I
G
I
K
Q
H
V
A
N
L
P
E
V
IKSP
S
L
V
D
F
V
N
A
L---------KNRD---
T
--
A
I
I
V
STGPSLNKQ-
L
P
L
L
K
E
I-AP
Y
A
T
L
F
C
IDAS
F
P
I
L
A
RAGIKP
D
I
V
L
S
L
E
R
V
D
L
T
--
A
--
K
F
Y
E
ETPL
D
F
QE
G
V
I
F
A
L
T
-
S
I
V
H
------
K
R
L
I
Q
------
A
I
Q
K
G
---
V
K
QFSFRPFG-Y---
T
---
N
--
L
--
F
D
--
L
-HQYGYVGIG
M
S
A
A
N
M
A
Y
E
L
V
V
H
S
R
F
K
R
C
V
F
IGQDLSFSQSGNSHASG
A
I
YGDREIKPKKDK
D
K
I
F
I
E
KYGGNG-
K
--
V
E
T
T
L
V
W
K
L
F
L
E
F
F
E
K
D
IFNTP
Y
K
L
E
V
I
NATEGG
A
R
I
KGTKEM
P
F
K
E
V
C
E
K
I
DKSKPKPP
I
N
L
IYPTQSEQA
K
N
L
K
I
A
K
K
K
C
E
E
I
I
K
Y
A------NE
K
K
T
Q
V
E
E
A
F
L
K
V
A
E
-
F
L
E
K
V
E
K
L
H
-----
E
KNKLEE--L
D
F
E
E
L
E
N
L
S
A
E
I
D
N
V
-
K
E
L
FDDK
R
F
N
S
Y
F
M
D
A
I
Q
S
Y
I
F
H
Q
E
L
H
I
A
E
I
V
C
KKTSNEDGL
R
A
K
Q
L
E
Y
I
Y
A
H
K
Y
W
L
F
SLAG
G
M
D
C
V
I
E
A
I
K
M
A
L
KEW
21
HHSearch
74.04
9%
-58
- C3 -
2WQQ
2
?
A:
[2-235]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
K
--
V
I
I
A
G
N
G
P
S
L
K
E
I
-
D
Y
S
R
L
---
P
N
D
F
D
V
F
R
C
N
Q
F
Y
F
E
D
K
Y
Y
L
G
K
K
C
K
A
V
F
Y
N
P
S
L
F
F
E
Q
Y
--
Y
T
L
K
H
L
I
Q
N
Q
E
Y
E
T
E
L
I
M
C
-
S
N
Y
N
QAHLEN
E
N
F
V
K
------
T
F
Y
D
Y
----
F
P
D
A
H
L
G
Y
D
F
F
K
QL
K
---
D
--
F
N
A
Y
F
--
K
-
F
H
E
I
Q
F
N
Q
R
I
T
S
G
V
Y
M
C
A
V
A
I
A
L
G
Y
K
E
I
Y
L
S
G
I
D
F
Y
-------
Y
A
F
D
T
K
----
Q
--------
K
N
L
L
K
L
A
P
N
F
K
-------
G
H
S
K
N
T
D
I
K
A
L
E
F
L
E
K
T
Y
--
K
I
K
L
Y
C
L
C
P
N
S
L
L
A
N
F
I
G
L
A
P
N
L
N
S
N
F
I
I
Q
E
K
N
N
Y
T
K
D
I
L
I
P
S
S
E
A
Y
G
K
F
S
K
N
I
---------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
69.86
10%
-53
- C3 -
1RO7
1
?
A:
[1-236]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
---
K
--
V
I
I
A
G
N
G
P
S
L
K
E
I
-
D
Y
S
R
L
---
P
N
D
F
D
V
F
R
C
N
Q
F
Y
F
E
D
K
Y
Y
L
G
K
K
C
K
A
V
F
Y
N
P
S
L
F
F
--
E
Q
Y
Y
T
L
K
H
L
I
Q
N
Q
E
Y
E
T
E
L
I
M
C
-
S
N
Y
N
------
Q
A
H
L
E
N
E
N
F
V
K
T
F
Y
D
Y
---
F
P
D
A
H
L
G
Y
D
F
-
F
---
K
---
Q
L
K
D
--
F
N
A
Y
F
K
F
H
E
I
Y
F
N
Q
R
I
T
S
G
V
Y
M
C
A
V
A
I
A
L
G
Y
K
E
I
Y
L
S
G
I
D
F
Y
Q
N
-
G
-
S
S
Y
A
F
D
T
K
----
Q
--------
K
N
L
L
K
L
A
P
N
F
K
N
D
NS
H
Y
I
G
H
S
K
N
T
D
I
K
A
L
E
F
L
E
K
T
Y
--
K
I
K
L
Y
C
L
C
P
N
S
L
L
A
N
F
I
E
L
A
P
N
L
N
S
N
F
I
I
Q
E
K
N
N
Y
T
K
D
I
L
I
P
S
S
E
A
Y
G
K
F
S
K
N
I
---------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
67.04
13%
-36
- C1 -
2GSA
2
GSA_SYNP6
A:
[6-432]
-----------------
F
K
T
I
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
------
R
Y
I
D
Y
V
G
-
T
W
G
---
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
K
-
G
T
S
F
G
A
P
C
A
L
--
E
-
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
R
D
K
I
I
K
F
E
G
C
Y
H
G
------
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
-----------
S
S
P
G
V
P
K
K
T
T
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
---------
A
E
N
P
GEI
A
--
G
V
I
L
E
------------------------------
P
I
V
G
N
S
G
F
--------------------------
I
V
P
D
A
G
F
L
E
G
L
R
-
E
I
T
L
------
E
H
D
A
L
------
L
V
F
D
E
---
V
M
-
T
G
F
R
I
---------------------------
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
-----
I
I
G
G
G
L
P
V
---------
G
A
Y
G
G
K
R
E
I
M
Q
L
V
A
P
A
G
P
M
Y
Q
A
G
T
L
S
G
-
N
--
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
Q
P
---------------------------------------------------
G
T
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
------
Q
E
T
G
H
A
A
C
--
G
G
Q
V
S
G
-
M
F
G
F
F
F
T
E
G
-----
P
V
H
N
Y
E
D
--
A
-----------------
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
----------------------
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
23
HHSearch
61.59
10%
-55
- C3 -
2P2V
14
?
A:
[8-248]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
M
E
N
E
L
I
V
S
----------
K
N
M
Q
---
N
--
I
I
I
A
G
N
G
P
S
L
K
N
I
-
N
Y
K
R
L
P
---
R
E
Y
D
V
F
R
C
N
Q
F
Y
F
E
D
K
Y
Y
L
G
K
K
I
K
A
V
F
F
N
P
G
V
F
L
--
Q
Q
Y
H
T
A
K
Q
L
I
L
K
N
E
Y
E
I
K
N
I
F
C
S
T
F
N
L
------
P
F
I
-
E
------
S
N
D
F
L
H
Q
F
Y
N
F
F
P
D
A
K
L
G
-
Y
E
V
I
E
NL
K
E
--
F
Y
A
Y
I
--
K
-
Y
N
E
I
Y
F
N
K
R
I
T
S
G
V
Y
M
C
A
I
A
I
A
L
G
Y
K
T
I
Y
L
C
G
I
D
F
Y
E
G
-
D
-
V
I
Y
P
F
E
A
M
S
------------
T
N
I
K
T
I
F
P
G
--D
F
K-
P
S
N
C
H
S
K
E
Y
D
I
E
A
L
K
L
L
-
K
S
I
Y
-
K
V
N
I
Y
A
L
C
D
D
S
-
I
L
A
N
H
F
P
L
S
I
N
I
N
N
N
F
T
L
E
N
K
H
N
N
S
I
N
D
I
L
L
T
D
N
T
P
G
V
S
F
Y
K
N
Q
L
K
A
D
N
K
I
M
-----------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
59.02
25%
82
- C3 -
4HSE
-
CLPB_THET8
A:
[306-379]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
E
I
A
K
L
R
A
E
W
E
R
E
R
E
I
L
R
K
L
------
R
E
A
Q
H
R
L
D
E
----
V
R
R
-
E
I
E
L
A
E
R
Q
Y
-----
D
L
N
R
A
A
E
--
L
R
Y
G
E
L
P
K
L
E
A
E
V
E
A
L
-
S
E
K
L
R
G
A
R
F
V
R
L
E
V
T
E
E
D
I
A
E
I
V
S
R
-----------------------------------------------------
1
PsiBlast_PDB
57.48
31%
31
- C3 -
4FSH
-
AROE_HELPY
A:
[115-194]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Q
N
Y
Q
N
A
L
I
L
G
S
---
G
G
S
A
K
A
-----------
L
A
C
G
L
K
K
Q
G
L
K
V
S
V
L
N
R
S
P
R
G
L
D
F
F
Q
R
L
GCDCFMEPP
K
S
A
F
---
D
--
L
I
I
N
A
T
S
A
S
L
N
----
P
L
N
K
E
V
-
L
K
G
Y
F
K
E
A
K
L
A
Y
D
L
A
Y
G
F
L
T
P
F
L
A
L
A
K
E
L
K
I
P
F
Q
D
--
G
--
K
D
M
L
I
Y
Q
A
S
L
S
F
E
K
F
S
A
S
Q
-
I
P
Y
S
------
K
A
F
E
V
------
M
R
S
V
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
56.74
28%
-77
- C3 -
3L07
1
FOLD_FRATT
A:
[18-115]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
L
A
T
Q
V
Q
E
Y
K
H
H
T
A
I
T
P
K
L
V
A
I
I
V
G
N
D
P
A
S
K
T
Y
V
A
S
K
E
K
A
C
A
Q
V
G
I
D
S
Q
V
I
T
L
P
E
H
T
T
E
S
E
L
L
E
L
I
D
Q
L
---------
N
N
D
S
---
S
VH
A
I
L
V
--------
Q
-
L
P
L
P
A
H
I
-
N
K
N
N
V
I
Y
S
I
K
P
E
K
D
V
D
G
F
H
P
T
N
V
G
R
L
Q
L
R
D
K
K
C
L
E
--
S
--
C
T
P
K
G
I
M
T
M
L
R
E
Y
G
I
K
T
E
G
-
A
Y
A
V
------
V
V
G
A
S
------
N
V
V
G
K
---
P
V
S
Q
L
L
L
N
A
K
-
A
---
T
---
V
--
T
--
T
C
--
H
-
R
F
T
T
D
L
K
S
H
T
T
K
A
D
I
L
I
V
A
V
G
K
P
N
F
I
T
A
D
M
V
K
E
G
A
V
V
I
D
V
G
I
N
H
V
D
G
K
I
V
G
D
V
D
F
A
A
V
K
D
K
V
A
A
I
T
P
V
P
G
G
V
G
-
P
--
M
T
I
T
E
L
L
Y
N
T
F
Q
C
A
Q
E
L
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
55.54
12%
-34
- C3 -
4OMV
-
?
A:
[3-205]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
L
L
Y
T
K
K
D
D
I
Y
S
D
I
V
R
M
-
I
L
L
I
K
G
A
N
A
K
I
V
D
V
S
K
E
E
N
S
K
H
L
E
E
L
N
I
I
T
P
N
G
N
I
P
T
L
S
T
D
D
F
A
V
Y
R
-
L
S
V
I
I
E
A
I
E
D
L
Y
P
F
P
PMFPVF
P
K
Q
R
A
N
A
R
I
L
L
E
Y
V
N
K
T
F
L
Q
N
I
I
K
L
Q
-----
S
P
D
L
D
E
K
--
Q
A
N
E
I
K
M
L
M
Q
R
D
I
I
S
T
Y
K
K
I
V
S
E
R
A
Q
N
I
N
V
L
T
L
I
I
T
F
V
F
Y
Y
F
I
K
L
K
----
I
S
I
P
T
K
D
K
N
I
I
K
E
I
K
E
L
L
S
E
P
N
F
I
K
T
I
K
A
----------------
13
PsiBlast_PDB
54.48
25%
73
- C3 -
1QVR
-
CLPB_THET8
A:
[443-516]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
E
I
A
K
L
R
A
E
W
E
R
E
R
E
I
L
R
K
L
------
R
E
A
Q
H
R
L
D
E
----
V
R
R
-
E
I
E
L
A
E
R
Q
Y
-----
D
L
N
R
A
A
E
--
L
R
Y
G
E
L
P
K
L
E
A
E
V
E
A
L
-
S
E
K
L
R
G
A
R
F
V
R
L
E
V
T
E
E
D
I
A
E
I
V
S
R
W
T
G
I
P
V
S
K
L
L
E
G
E
R
E
K
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
26
HHSearch
51.41
25%
-74
- C3 -
3LM8
2
THIN_BACSU
A:
[2-50]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
T
--
I
N
I
V
A
G
G
P
K
N
L
I
P
D
L
T
G
Y
--
T
-
D
E
H
T
L
W
I
G
V
D
K
G
T
V
T
L
L
D
A
G
I
I
P
V
E
A
F
G
D
F
D
S
I
T
E
--
Q
--
E
R
R
R
I
E
K
A
A
P
A
L
H
V
Y
Q
A
E
K
-
D
Q
T
D
------
L
D
L
A
L
------
D
W
A
L
E
---
K
Q
P
D
I
I
Q
I
F
G
-
I
---
T
---
G
--
G
--
R
A
--
D
-
H
F
L
G
N
I
Q
L
L
Y
K
G
V
K
T
N
I
K
I
R
L
I
D
K
Q
N
H
I
Q
M
F
P
P
G
E
Y
D
I
E
K
D
E
N
K
R
Y
I
S
F
I
P
F
S
E
D
I
H
E
L
T
L
T
G
F
K
Y
P
L
N
N
C
H
I
-
T
--
L
G
S
T
L
C
I
S
N
E
L
I
H
S
R
G
T
F
S
F
V
K
G
I
L
I
M
I
R
S
T
D
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
49.73
31%
133
- C3 -
3DTP
-
MYH11_CHICK (first)
A:
[903-969]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
E
Q
-
D
N
L
A
D
A
E
E
R
C
D
Q
L
I
K
----------
N
K
I
Q
L
E
A
K
V
K
E
M
N
E
-
R
L
E
D
E
E
E
M
N
A
E
L
T
A
K
K
R
K
L
E
------
D
E
C
S
E
L
K
R
D
I
D
D
L
-
E
L
T
L
--------------------------------------------------------------------------
29
HHSearch
49.44
26%
-72
- C3 -
3L8M
1
?
A:
[2-47]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
A
N
L
L
C
G
N
R
N
L
P
K
H
-
I
--
L
V
E
--
H
K
H
E
H
W
I
G
I
D
R
G
T
L
I
L
L
E
S
G
I
T
P
Q
F
A
V
G
D
F
D
S
I
S
D
--
S
--
E
R
N
F
I
Q
Q
Q
I
E
I
N
P
Y
N
D
D
T
D
-
L
A
L
G
------
I
D
Q
A
V
------
K
R
G
Y
R
---
N
I
D
V
Y
G
A
T
G
G
-
R
---
L
---
D
--
H
--
F
M
--
G
-
A
L
Q
I
L
E
K
P
E
Y
A
K
M
N
I
N
I
K
L
I
D
D
T
N
E
I
Q
F
I
Q
K
G
Q
F
N
V
F
P
Y
I
S
F
I
P
V
I
P
T
V
I
S
L
K
G
F
K
Y
N
L
Q
N
E
L
T
I
S
N
E
L
C
G
N
I
-
E
--
I
I
E
G
S
V
L
M
I
R
S
K
D
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
49.24
23%
-64
- C3 -
2OMK
-
?
A:
[5-56]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Y
I
P
---
Q
--
A
I
I
L
A
N
G
E
Y
P
A
H
E
-
L
P
-
L
R
L
L
-
A
E
A
Q
F
V
V
C
C
--
A
A
N
E
Y
I
S
R
G
H
T
P
D
V
I
I
G
D
G
D
S
L
L
P
--
E
--
Y
K
K
R
F
S
S
I
I
L
Q
I
S
D
Q
E
T
N
D
-
Q
T
K
A
------
V
H
Y
L
Q
------
S
K
G
I
R
---
K
I
A
I
V
G
A
T
G
K
-
R
---
E
---
D
--
H
--
T
L
--
G
-
N
I
S
L
L
V
E
Y
M
R
S
G
M
E
V
R
T
V
T
D
Y
G
T
F
I
P
V
S
D
T
Q
S
F
A
S
Y
P
G
Q
Q
V
S
I
I
N
F
G
A
K
G
L
K
A
E
G
L
F
Y
P
L
S
D
F
T
N
W
W
Q
G
T
L
N
E
-
A
--
I
A
D
E
F
T
I
H
C
T
G
E
Y
L
V
F
L
A
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
45.61
18%
-76
- C3 -
1INL
-
SPEE_THEMA
A:
[90-152]
-------------------------------------------------------------------------
N
P
K
K
V
L
I
I
G
G
G
D
G
G
T
L
R
E
V
L
K
H
D
S
V
E
K
A
I
L
C
E
V
D
G
L
V
I
E
A
A
R
K
Y
L
K
Q
T
--
S
C
G
F
D
D
P
R
A
E
I
V
I
A
N
G
A
E
Y
V
R
K
F
K
N
E
F
D
V
I
I
I
D
S
L
F
T
E
E
F
Y
Q
A
C
Y
D
A
L
K
E
D
G
V
F
S
A
E
T
E
D
P
F
Y
D
I
G
W
F
K
L
A
Y
R
R
I
S
K
V
F
-----------
P
I
T
R
V
Y
L
G
F
M
T
T
Y
P
S
G
M
W
S
Y
T
F
A
S
K
G
I
D
---------
P
I
K
D
---
F
--
D
P
E
K
V
R
K
F
N
K
E
L
K
-
Y
Y
N
E
E
V
H
-
V
A
S
F
A
L
P
N
F
V
K
K
E
L
G
L
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
45.59
21%
-51
- C3 -
3CQ9
-
?
A:
[3-49]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
---
I
--
V
N
L
L
V
G
G
P
T
A
N
Y
P
-
A
D
-
L
T
---
T
I
P
G
P
W
V
G
A
D
R
G
A
L
R
L
V
K
R
G
I
Q
P
V
M
V
V
G
D
F
T
V
K
D
A
--
L
--
V
G
A
I
V
V
K
P
D
Q
D
H
T
D
T
Q
L
A
I
-
K
S
I
F
------
E
Q
L
Q
P
------
D
E
V
H
L
---
Y
G
A
T
G
G
R
L
D
H
-
L
---
L
---
A
--
N
--
M
W
--
L
-
V
L
D
P
V
F
R
Q
W
A
P
Q
I
K
L
I
D
K
Q
N
S
V
R
F
F
L
P
G
D
Y
Q
I
T
K
E
A
D
K
R
Y
L
A
F
V
P
L
M
P
M
H
L
T
L
P
D
E
K
Y
Q
L
D
A
A
Y
N
A
Y
P
I
S
W
A
S
-
N
--
E
F
S
G
N
T
G
H
F
S
F
D
A
G
V
L
A
V
I
Q
S
R
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
42.44
21%
-31
- C3 -
3K94
-
?
A:
[2-49]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
--
I
H
I
V
G
G
G
P
R
E
L
L
P
---
D
L
R
F
Y
D
G
E
D
V
C
W
V
G
V
D
R
G
T
M
T
L
L
E
A
G
F
R
P
V
R
A
F
G
D
F
D
S
L
P
A
--
E
--
D
V
V
K
L
Q
Q
A
F
P
D
L
D
V
W
P
A
E
K
-
D
K
T
D
------
M
E
I
A
L
------
D
W
A
V
E
---
Q
T
A
R
C
I
R
L
F
G
-
A
---
T
---
G
--
G
--
R
L
--
D
-
H
L
F
G
N
V
E
L
L
L
K
Y
A
D
R
P
I
E
I
V
D
R
Q
N
V
L
T
V
H
L
P
G
T
Y
T
V
M
Y
D
A
R
Y
C
Y
V
S
Y
I
P
V
S
E
T
V
A
E
F
T
L
T
G
F
K
Y
P
L
T
N
C
H
I
S
R
-
G
--
S
T
L
C
I
S
N
E
L
I
Q
S
S
G
T
F
S
F
S
E
G
I
L
M
M
I
R
S
S
D
S
S
C
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
42.17
14%
197
- C3 -
3E7K
-
TRPM7_RAT
A:
[2-55]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
S
------
R
V
T
F
E
R
V
E
Q
M
S
I
Q
I
K
E
-
V
G
D
R
V
N
Y
I
K
-----
R
S
L
Q
S
L
D
--
S
Q
I
G
H
L
Q
D
L
S
A
L
T
V
D
T
-
L
K
T
---------------------------------------------------------------------------
36
HHSearch
42.13
14%
-86
- C3 -
1UIR
-
SPEE_THET8
A:
[77-141]
-------------------------------------------------------------------------
E
P
K
R
V
L
I
V
G
G
G
E
G
A
T
L
R
E
V
L
K
H
P
T
V
E
K
A
V
M
V
D
I
D
G
E
L
V
E
V
A
K
R
H
M
P
E
W
HQ
G
-
A
F
D
D
P
R
A
V
L
V
I
D
D
A
R
A
Y
L
E
R
T
E
E
R
Y
D
V
V
I
I
D
L
T
D
P
V
G
E
D
N
P
A
R
L
L
Y
T
V
E
F
Y
R
L
V
K
A
H
L
N
P
G
G
V
M
G
M
Q
T
G
M
I
L
L
R
V
H
P
-----------
V
V
H
R
T
V
R
E
A
F
R
Y
V
R
S
Y
K
N
H
I
P
G
F
F
L
N
F
G
---------
F
L
L
A
---
S
--
D
A
F
D
P
A
A
F
S
E
G
V
I
-
E
A
R
I
R
E
R
-
N
L
A
L
R
H
L
T
A
P
Y
L
E
A
M
F
V
L
P
K
D
L
L
E
A
L
E
K
E
T
M
V
S
T
D
--
Q
--
N
P
F
Y
V
T
P
E
G
E
A
R
Q
A
P
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
41.78
30%
111
- C3 -
2ALZ
5
POLI_HUMAN
A:
[56-111]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
R
D
A
K
E
K
C
P
Q
L
V
L
V
N
------
G
E
D
L
T
R
Y
R
E
M
S
Y
K
V
T
E
-
L
L
E
E
F
S
P
V
V
-----
E
R
L
G
F
D
E
N
F
V
D
L
T
E
M
V
E
K
R
L
Q
Q
L
Q
S
-
D
E
L
S
A
V
T
V
S
G
H
V
Y
N
N
Q
S
I
N
L
L
D
V
L
H
I
R
L
L
V
G
S
Q
I
A
A
E
M
R
E
A
M
Y
N
Q
L
G
L
T
G
C
A
G
V
A
S
N
K
L
L
A
K
L
V
S
G
V
F
K
P
N
Q
Q
T
V
L
L
P
17
PsiBlast_PDB
41.71
30%
115
- C3 -
1T3N
2
POLI_HUMAN
A:
[54-109]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
R
D
A
K
E
K
C
P
Q
L
V
L
V
N
------
G
E
D
L
T
R
Y
R
E
M
S
Y
K
V
T
E
-
L
L
E
E
F
S
P
V
V
-----
E
R
L
G
F
D
E
N
F
V
D
L
T
E
M
V
E
K
R
L
Q
Q
L
Q
S
-
D
E
L
S
A
V
T
V
S
G
H
V
Y
N
N
Q
S
I
N
L
L
D
V
L
H
I
R
L
L
V
G
S
Q
I
A
A
E
M
R
E
A
M
Y
N
Q
L
G
L
T
G
C
A
G
V
A
S
N
K
L
L
A
K
L
V
S
G
V
F
K
P
N
Q
Q
T
V
L
L
P