@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0107: (2015-12-12 )
MSFRINTNIAALTSHAVGVQNNRDLSSSLEKLSSGLRINKAADDSSGMAIADSLRSQSANLGQAIRNANDAIGMVQTADKAMDEQIKILDTIKTKAVQAAQDGQTLESRRALQSDIQRLLEELDNIANTTSFNGQQMLSGSFSNKEFQIGAYSNTTVKASIGSTSSDKIGHVRMETSSFSGEGMLASAAAQNLTEVGLNFKQVNGVNDYKIETVRISTSAGTGIGALSEIINRFSNTLGVRASYNVMATGGTPVQSGTVRELTINGVEIGTVNDVHKNDADGRLTNAINSVKDRTGVEASLDIQGRINLHSIDGRAISVHAASASGQVFGGGNFAGISGTQHAVIGRLTLTRTDARDIIVSGVNFSHVGFHSAQGVAEYTVNLRAVRGIFDANVASAAGANANGAQAETNSQGIGAGVTSLKGAMIVMDMADSARTQLDKIRSDMGSVQMELVTTINNISVTQVNVKAAESQIRDVDFAEESANFSKYNILAQSGSFAMAQANAVQQNVLRLLQ
Atome Classification :
(20 SA)
--.........10........20........30........40........50.----------.......60........70........80.-.---......90........100.......--------110.......120.......130....----...140-----.-......150-----...-----....160..-......----.170....---------.-----------..180...----....190.......200.......210....---------...220........230---.......240......-------------.250......-.260.......270......---.280.......290....-.-----..300.......310.......320---------...-----....330.......340.......350.......360.......--370--........380.-......390--------.......400.......410.......---420..-----.....430....--------------...440.......---450.......460.......-470.......480.......490.......500.......510..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--M
S
F
R
INT
N
I
A
A
L
T
S
H
A
VGVQNNR
D
L
S
S
S
L
E
K
L
S
SG
L
R
I
NKAADDSS
G
M
A
I
A
D
----------
S
L
R
S
QS
A
N
L
G
Q
A
I
R
NANDAI
G
M
V
Q
T
A
D
K
A
M
-
D
---
E
Q
I
K
I
L
D
T
I
K
T
K
A
V
QAAQDG
Q
T
L
E
S
R
--------
R
A
L
Q
S
D
I
Q
R
L
L
E
E
L
D
N
I
ANTTSFNG
Q
Q
----
M
LSGSF-----S-NK
E
F
Q
I
G
AY-----SN
T
-----
T
V
K
A
S--IG-STSSDK----I
G
H
V
R
M
ET---------S-----------SFSGEGM
L
----
A
S
A
A
A
Q
N
L
T
E
VGL
N
F
K
QVNGVN
D
Y
K
I
E
T
V
R
I
---------STSA-GT
G
I
G
A
L
S
E
I
I
N
---
R
F
S
NTLGVR
A
S
Y
N
V
M
A-------------TGGTPVQSG
T
-
V
R
E
L
T
IN
G
V
E
I
G
T
VNDVHKN---DADG
R
L
T
N
A
I
N
S
V
KDRTG-V-----
E
A
S
L
D
I
Q
G
R
I
N
L
H
SIDG
R
A
I
S
V
H
AA---------SAS-----
G
Q
V
FGGG
N
F
AGISGT
Q
H
A
V
I
G
R
L
T
L
TRTDAR
D
I
I
VSGVNFSHVG--FH---SAQG
V
A
E
Y
T
V
N
L
-
R
A
V
R
G
I
FDA--------NVASAAGANANGAQAETNSQGIG
A
G
V
T
---SLKG
A
-----
M
I
V
M
DM
A
D
S
A
R
T
--------------
Q
L
D
K
I
R
S
D
M
G
S
V
Q
---
M
E
L
V
T
T
IN
N
I
S
V
T
Q
V
N
V
K
A
A
-ESQIRDVDF
A
E
ESANFS
K
Y
N
I
L
AQSG
S
F
A
M
A
Q
A
N
A
V
Q
Q
N
V
L
R
LLQ
26
Fugue
82.99
24%
-20
- C3 -
1UCU
-
FLIC_SALTY
A:
[1-494]
---
A
Q
V
I
N
T
N
S
L
S
L
L
T
Q
N
N
L
N
K
S
Q
S
A
L
G
T
A
I
E
R
L
S
S
G
L
R
I
N
S
A
K
D
D
A
A
G
Q
A
I
A
N
----------
R
F
T
A
N
I
K
G
L
T
Q
A
S
R
N
A
N
D
G
I
S
I
A
Q
T
T
E
G
A
L
-
N
---
E
I
N
N
N
L
Q
R
V
R
E
L
A
V
Q
S
A
N
S
T
N
S
Q
S
D
L
--------
D
S
I
Q
A
E
I
T
Q
R
L
N
E
I
D
R
V
S
G
Q
T
Q
F
N
G
V
K
----
V
L
A
Q
D
------
N
-
T
L
T
I
Q
V
G
A
N
-----
D
G
E
-----
T
I
D
I
D
--
L
K
-
Q
I
N
S
Q
T
----
L
G
L
D
T
L
N
V
---------
Q
-----------
Q
--------------
K
Y
K
V
S
D
T
A
A
T
V
T
G
Y
A
D
T
T
I
A
L
D
N
S
T
F
K
A
---------
S
A
T
G
-
L
G
G
T
D
Q
K
I
D
G
D
L
---
K
F
D
D
T
T
G
-
K
Y
Y
A
K
V
T
V
-------------
T
G
G
T
G
K
D
G
Y
Y
-
E
V
S
V
D
K
T
N
G
E
V
T
L
A
G
G
A
T
S
P
---
L
T
G
G
L
P
A
T
A
T
E
D
V
K
N
V
Q
V
A
N
-----
A
D
L
T
E
A
K
A
A
L
T
A
A
G
V
T
G
T
A
S
V
V
K
M
S
---------
Y
T
D
-----
N
------
N
G
K
T
I
D
G
G
L
A
V
K
V
G
D
D
Y
Y
S
A
T
Q
N
K
D
G
S
I
S
I
N
T
T
K
Y
T
A
--
D
D
---
G
T
S
K
T
A
L
N
K
L
G
---
G
A
D
G
K
T
E
V
--------
V
S
I
G
G
K
T
Y
A
A
S
K
A
E
G
H
N
F
K
A
Q
P
D
L
A
E
A
---
A
A
T
T
T
-----
E
N
P
L
Q
K
I
D
A
A
L
A
--------------
Q
V
D
T
L
R
S
D
L
G
A
V
Q
---
N
R
F
N
S
A
I
T
N
L
G
N
T
V
N
N
L
T
S
V
-
R
S
R
I
E
D
S
D
Y
A
T
E
V
S
N
M
S
R
A
Q
I
L
Q
Q
A
G
T
S
V
L
A
Q
A
N
Q
V
P
Q
N
V
L
S
L
L
R
11
PsiBlast_PDB
79.43
22%
-17
- C3 -
1IO1
-
FLIC_SALTY
A:
[60-449]
------------------------------------------------------------------------
L
T
Q
A
S
R
N
A
N
D
G
I
S
I
A
Q
T
T
E
G
A
L
-
N
---
E
I
N
N
N
L
Q
R
V
R
E
L
A
V
Q
S
A
N
S
T
N
S
Q
S
D
L
--------
D
S
I
Q
A
E
I
T
Q
R
L
N
E
I
D
R
V
S
G
Q
T
Q
F
N
G
V
K
----
V
L
A
Q
D
------
N
-
T
L
T
I
Q
V
G
A
N
-----
D
G
E
-----
T
I
D
I
D
--
L
K
-
Q
I
N
S
Q
T
----
L
G
----------------------------------
L
----
D
T
L
N
V
Q
Q
K
Y
K
V
S
D
T
A
A
T
V
T
G
Y
A
D
T
T
I
A
L
D
N
S
---------
T
F
K
A
S
A
T
G
L
G
G
T
D
Q
K
I
D
G
D
L
K
F
D
D
T
T
G
-
K
Y
Y
A
K
V
T
V
-------------
T
G
G
T
G
K
D
G
----------------
Y
Y
E
V
S
V
D
---
K
T
N
G
E
V
T
L
A
G
G
A
T
S
P
L
T
G
-
G
-----
L
P
A
T
A
T
E
D
V
K
N
V
Q
V
A
N
A
D
L
T
E
A
K
A
A
---------
L
T
A
--------------
A
G
V
T
G
T
A
S
V
V
----
K
M
S
Y
T
D
N
N
G
K
T
I
D
G
G
L
A
V
K
V
G
DD
Y
Y
---
S
A
T
Q
N
K
D
G
S
I
S
I
-
N
T
T
K
Y
T
A
D
D
--------
G
T
S
K
T
A
L
N
K
L
G
G
A
D
G
K
T
E
V
V
S
I
G
G
K
T
Y
---
A
A
S
K
A
EGHNF
K
A
Q
P
D
L
A
E
A
A
A
T
T
T
E
N
P
L
Q
K
I
D
A
A
L
A
Q
V
D
T
L
R
S
D
L
A
A
V
Q
---
N
R
F
N
S
A
I
T
N
L
G
N
T
V
N
N
L
T
S
A
-
R
--------------------------------------------
27
Fugue
68.62
17%
-13
- C3 -
1IO1
-
FLIC_SALTY
A:
[56-450]
--------------------------------------------------------------------
N
I
K
G
L
T
Q
A
S
R
N
A
N
D
G
I
S
I
A
Q
T
T
E
G
A
L
-
N
---
E
I
N
N
N
L
Q
R
V
R
E
L
A
V
Q
S
A
N
S
T
N
S
Q
S
D
L
--------
D
S
I
Q
A
E
I
T
Q
R
L
N
E
I
D
R
V
S
G
Q
T
Q
F
N
G
V
K
----
V
L
A
Q
D
------
N
-
T
L
T
I
Q
V
G
A
N
-----
D
G
E
-----
T
I
D
I
D
--
L
K
-
Q
I
N
S
Q
T
----
L
G
L
D
T
L
N
V
---------
Q
-----------
Q
--------------
K
Y
K
V
S
D
T
A
A
T
V
T
G
Y
A
D
T
T
I
A
L
D
N
S
T
F
K
A
---------
S
A
T
G
-
L
G
G
T
D
Q
K
I
D
G
D
L
---
K
F
D
D
T
T
G
K
Y
Y
A
K
V
T
V
T
-------------
G
G
T
G
K
D
G
Y
Y
E
-
V
S
V
D
K
T
N
G
E
V
T
L
A
G
G
A
T
S
P
L
---
T
G
G
L
P
A
T
A
T
E
D
V
K
N
V
Q
V
A
-
N
-----
A
D
L
T
E
A
K
A
A
L
T
A
A
G
V
T
G
T
A
S
V
V
K
M
S
---------
Y
T
D
-----
N
N
----
G
K
T
I
D
G
G
L
A
V
K
V
G
D
D
Y
Y
S
A
T
Q
N
K
D
G
S
I
S
I
N
T
T
K
Y
T
A
---------
D
D
G
T
S
K
T
A
L
N
K
L
-
G
G
A
D
G
K
T
E
V
--------
V
S
I
G
G
K
T
Y
A
A
S
K
A
E
G
H
N
F
K
A
Q
P
D
L
A
E
A
---
A
A
T
T
T
-----
E
N
P
L
Q
K
I
D
A
A
L
A
--------------
Q
V
D
T
L
R
S
D
L
A
A
V
Q
---
N
R
F
N
S
A
I
T
N
L
G
N
T
V
N
N
L
T
S
A
-
R
--------------------------------------------
2
PsiBlast_PDB
63.13
38%
-30
- C3 -
3K8V
-
?
A:
[44-239]
---------------------------------------------
D
A
A
G
L
A
I
S
D
----------
R
M
T
A
Q
I
K
G
L
T
Q
A
Q
R
N
A
N
D
G
I
S
L
A
Q
T
A
E
G
A
L
-
G
---
E
I
S
N
N
L
Q
R
I
R
E
L
A
V
Q
A
S
N
G
T
N
T
Q
T
D
R
--------
D
A
L
Q
A
E
V
T
Q
L
Q
S
E
I
Q
R
V
A
E
Q
T
S
F
N
G
Q
K
----
L
L
D
G
S
F
-----
N
-
G
V
Q
F
Q
I
G
A
N
-----
A
G
E
-----
T
I
G
V
S
KI
M
N
-
A
Q
T
A
S
L
----
G
G
S
L
T
R
T
T
---------
S
-----------
T
I
D
A
T
D
L
T
KYD-
T
A
M
A
A
G
D
L
T
--------
I
N
G
V
D
V
G
K
I
D
A
------------
A
S
T
A
-
Q
E
R
A
A
Q
L
T
E
A
I
N
---
R
V
S
S
Q
T
N
V
G
A
S
Y
D
K
T
T
-------------
G
Q
V
T
L
T
S
N
A
A
-
I
A
V
A
G
A
A
N
D
A
T
V
A
G
W
A
N
N
A
T
---
T
G
T
A
T
T
T
T
G
I
N
S
L
T
V
S
S
F
-
T
-----
N
A
Q
Q
T
I
T
Q
I
D
N
A
L
K
D
I
N
T
A
R
A
D
L
G
A
---------
V
Q
N
-----
R
F
T
S
T
V
A
N
L
Q
S
M
T
E
N
L
S
S
A
R
G
R
V
T
D
A
D
F
A
S
E
T
A
N
L
S
R
A
Q
I
L
Q
Q
A
--
L
E
---
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
62.91
38%
-28
- C3 -
3K8W
-
?
A:
[44-239]
---------------------------------------------
D
A
A
G
L
A
I
S
D
----------
R
M
T
A
Q
I
K
G
L
T
Q
A
Q
R
N
A
N
D
G
I
S
L
A
Q
T
A
E
G
A
L
-
G
---
E
I
S
N
N
L
Q
R
I
R
E
L
A
V
Q
A
S
N
G
T
N
T
Q
T
D
R
--------
D
A
L
Q
A
E
V
T
Q
L
Q
S
E
I
Q
R
V
A
E
Q
T
S
F
N
G
Q
K
----
L
L
D
G
S
F
-----
N
-
G
V
Q
F
Q
I
G
A
N
-----
A
G
E
-----
T
I
G
V
S
KI
M
N
-
A
Q
T
A
S
L
----
G
G
S
L
T
R
T
T
---------
S
-----------
T
I
D
A
T
D
L
T
KYD-
T
A
M
A
A
G
D
L
T
--------
I
N
G
V
D
V
G
K
I
D
A
------------
A
S
T
A
-
Q
E
R
A
A
Q
L
T
E
A
I
N
---
R
V
S
S
Q
T
N
V
G
A
S
Y
D
K
T
T
-------------
G
Q
V
T
L
T
S
N
A
A
-
I
A
V
A
G
A
A
N
D
A
T
V
A
G
W
A
N
N
A
T
---
T
G
T
A
T
T
T
T
G
I
N
S
L
T
V
S
S
F
-
T
-----
N
A
Q
Q
T
I
T
Q
I
D
N
A
L
K
D
I
N
T
A
R
A
D
L
G
A
---------
V
Q
N
-----
R
F
T
S
T
V
A
N
L
Q
S
M
T
E
N
L
S
S
A
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
Fugue
61.25
10%
-5
- C1 -
2DKA
-
AGM1_CANAX
A:
[1-544]
----
M
S
I
E
Q
T
L
S
Q
Y
L
P
S
H
P
K
P
Q
G
V
T
-----
F
T
Y
G
T
A
G
F
R
M
K
A
D
K
L
D
Y
V
T
F
T
V
G
I
----------
I
A
S
L
R
S
K
Y
L
Q
------
G
K
T
V
G
V
M
I
T
A
S
N
P
P
E
D
---
N
G
V
K
V
V
D
P
L
G
S
M
L
E
S
S
W
E
K
Y
A
T
D
L
A
N
--------
A
S
P
S
P
E
K
N
S
L
V
E
V
I
K
N
L
V
S
D
L
K
I
D
L
S
I
P
A
N
V
V
I
A
R
D
S
-----
R
-
E
S
S
P
A
L
S
M
A
-----
T
I
D
-----
G
F
Q
S
V
--
P
N
-
T
K
Y
Q
D
F
GLFT
T
P
E
L
H
Y
V
T
---------
R
-----------
T
L
N
D
P
D
F
G
----
K
P
T
E
D
G
Y
Y
S
K
L
A
K
S
F
Q
E
I
Y
T
I
E
K
---
I
D
I
T
I
---------
D
A
A
N
-
G
V
G
A
P
K
I
Q
E
L
L
E
---
K
Y
L
H
K
E
I
S
F
T
V
V
N
G
D
Y
-------------
K
Q
P
N
L
L
N
F
D
C
G
A
D
Y
V
K
T
N
Q
K
L
P
K
N
V
K
P
V
N
N
K
L
Y
A
S
F
D
G
D
A
D
R
L
I
C
Y
Y
Q
N
N
D
N
-
K
-----
F
K
L
L
D
G
D
K
L
S
T
L
F
A
L
F
L
Q
Q
L
F
K
Q
I
D
---------
P
T
K
I
S
L
N
I
G
V
V
Q
T
A
Y
A
N
G
S
S
T
K
Y
V
E
D
V
L
K
I
P
V
R
C
T
P
T
G
V
K
H
L
H
H
E
A
E
N
F
D
I
G
--
V
Y
F
E
A
N
G
H
G
T
V
I
F
N
P
E
A
E
K
K
I
F
D
Y
K
P
N
--------
N
D
N
E
A
K
A
I
K
V
L
Q
N
F
S
Q
L
I
N
Q
T
V
G
D
A
I
S
---
D
L
L
A
V
-----
L
I
V
V
H
Y
L
K
L
S
P
S
--------------
D
W
D
N
E
Y
T
D
L
P
N
K
L
---
V
K
V
F
K
T
T
N
A
E
R
L
V
P
K
G
M
Q
D
E
I
D
K
L
V
A
Q
Y
P
N
G
R
S
F
V
R
A
S
A
V
R
V
Y
A
E
A
D
T
--
Q
N
N
V
E
E
L
S
K
A
V
S
E
L
V
K
3
PsiBlast_PDB
58.08
36%
-12
- C3 -
2ZBI
-
?
A:
[62-239]
-------------------------------------------------------------------------
T
Q
A
Q
R
N
A
N
D
G
I
S
L
A
Q
T
A
E
G
A
L
-
G
---
E
I
S
N
N
L
Q
R
I
R
E
L
A
V
Q
A
S
N
G
T
N
T
Q
T
D
R
--------
D
A
L
Q
A
E
V
T
Q
L
Q
S
E
I
Q
R
V
A
E
Q
T
S
F
N
G
Q
K
----
L
L
D
G
S
F
-----
N
-
G
V
Q
F
Q
I
G
A
N
-----
A
G
E
-----
T
I
G
V
S
K
-
I
M
-
N
A
Q
T
A
S
----
L
G
G
S
L
T
R
T
---------
T
-----------
S
T
I
D
A
T
D
L
TKYD
T
A
M
A
A
G
D
L
T
--------
I
N
G
V
D
V
G
K
I
D
A
------------
A
S
T
A
-
Q
E
R
A
A
Q
L
T
E
A
I
N
---
R
V
S
S
Q
T
N
V
G
A
S
Y
D
K
T
T
-------------
G
Q
V
T
L
T
S
N
A
A
-
I
A
V
A
G
A
A
N
D
A
T
V
A
G
W
A
N
N
A
T
---
T
G
T
A
T
T
T
T
G
I
N
S
L
T
V
S
S
F
-
T
-----
N
A
Q
Q
T
I
T
Q
I
D
N
A
L
K
D
I
N
T
A
R
A
D
L
G
A
---------
V
Q
N
-----
R
F
T
S
T
V
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
HHSearch
57.04
46%
-24
- C3 -
3K8W
-
?
A:
[44-161]
---------------------------------------------
D
A
A
G
L
A
I
S
D
----------
R
M
T
A
Q
I
K
G
L
T
Q
A
Q
R
N
A
N
D
G
I
S
L
A
Q
T
A
E
G
A
L
-
G
---
E
I
S
N
N
L
Q
R
I
R
E
L
A
V
Q
A
S
N
G
T
N
T
Q
T
D
R
--------
D
A
L
Q
A
E
V
T
Q
L
Q
S
E
I
Q
R
V
A
E
Q
T
S
F
N
G
Q
K
----
L
L
D
G
S
F
-----
N
-
G
V
Q
F
Q
I
G
A
N
-----
A
G
E
-----
T
I
G
V
S
--
K
I
-
M
N
A
Q
T
A
----
S
L
G
G
S
L
T
R
---------
T
-----------
T
S
T
I
D
A
T
D
----
L
T
K
Y
D
T
A
M
A
A
G
D
L
T
I
N
G
V
D
V
G
K
I
D
A
A
S
T
A
Q
E
---------
R
A
A
Q
-
L
T
E
A
I
N
R
V
S
S
Q
T
---
N
V
G
A
S
Y
D
K
T
T
G
Q
V
T
L
T
-------------
S
N
A
A
I
A
V
A
G
A
-
A
N
D
A
T
V
A
G
W
A
N
N
A
T
T
G
T
A
T
T
---
T
T
G
I
N
S
L
T
V
S
S
F
T
N
A
Q
Q
T
-
I
-----
T
Q
I
D
N
A
L
K
D
I
N
T
A
R
A
D
L
G
A
V
Q
N
R
F
T
---------
S
T
V
-----
A
N
L
Q
S
M
T
E
N
L
S
S
A
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
55.96
30%
-28
- C3 -
4NX9
-
?
A:
[10-155]
----------------------------------------------------------------------
N
G
L
N
V
A
T
K
N
A
N
D
G
I
S
L
A
Q
T
A
E
G
A
L
-
Q
---
Q
S
T
N
I
L
Q
R
M
R
D
L
S
L
Q
S
A
N
G
S
N
S
D
S
E
R
--------
T
A
L
N
G
E
V
K
Q
L
Q
K
E
L
D
R
I
S
N
T
T
T
F
G
G
R
K
----
L
L
D
G
S
F
-----
G
-
V
A
S
F
Q
V
G
S
A
-----
A
N
E
-----
I
I
S
V
G
--
I
D
-
E
M
S
A
E
S
----
L
N
G
T
Y
F
K
A
-----------------------
D
G
G
G
A
V
----
T
A
A
T
A
S
G
T
V
D
I
A
I
D
I
T
G
G
S
A
V
N
V
K
V
D
M
K
G
N
E
---------
T
A
E
Q
-
A
A
A
K
I
A
A
A
V
N
D
A
---
N
V
G
I
G
A
F
T
D
G
A
Q
I
S
Y
V
-------------
S
K
A
S
A
D
G
T
T
S
-
A
V
S
G
V
A
I
T
D
T
G
S
T
G
A
G
T
A
A
G
---
T
T
T
F
T
E
A
N
D
T
V
A
K
I
D
I
S
T
-
A
-----
K
G
A
Q
S
A
V
L
V
I
D
E
A
I
K
Q
I
D
A
Q
R
A
D
L
G
---------
A
V
Q
-----
N
R
F
D
N
T
I
N
N
L
K
N
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Fugue
55.90
18%
-3
- C3 -
2D4X
-
FLGL_SALTY
A:
[50-263]
-----------------------------------------------------
V
----------
V
L
S
Q
A
Q
A
Q
N
S
Q
Y
A
L
A
R
T
F
A
T
Q
K
V
S
L
E
E
S
V
L
-
S
---
Q
V
T
T
A
I
Q
T
A
Q
E
K
I
V
Y
A
G
N
G
T
L
S
D
D
D
R
--------
A
S
L
A
T
D
L
Q
G
I
R
D
Q
L
M
N
L
A
N
S
T
D
G
N
G
R
Y
----
I
F
A
G
Y
K
-----
T
-
E
A
A
P
F
D
Q
A
T
GGYHG
G
E
K
-----
S
V
T
Q
Q
--
V
D
-
S
A
R
T
M
V
----
I
G
H
T
G
A
Q
I
FNSITSNAV
P
-----------
E
P
D
G
S
D
S
E
----
K
N
L
F
V
M
L
D
T
A
I
A
A
L
K
T
P
V
E
G
N
N
V
E
K
E
K
A
A
A
A
---------
I
D
K
T
-
N
R
G
L
K
N
S
L
N
N
V
L
---
T
V
R
A
E
L
G
T
Q
L
S
E
L
S
T
L
-------------
D
S
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
54.23
34%
-31
- C3 -
1UCU
-
FLIC_SALTY
A:
[1-159]
---
A
Q
V
I
N
T
N
S
L
S
L
L
T
Q
N
N
L
N
K
S
Q
S
A
L
G
T
A
I
E
R
L
S
S
G
L
R
I
N
S
A
K
D
D
A
A
G
Q
A
I
A
N
----------
R
F
T
A
N
I
K
G
L
T
Q
A
S
R
N
A
N
D
G
I
S
I
A
Q
T
T
E
G
A
L
-
N
---
E
I
N
N
N
L
Q
R
V
R
E
L
A
V
Q
S
A
N
S
T
N
S
Q
S
D
L
--------
D
S
I
Q
A
E
I
T
Q
R
L
N
E
I
D
R
V
S
G
Q
T
Q
F
N
G
V
K
----
V
L
A
Q
D
N
-----
T
--
L
T
I
Q
V
G
A
N
-----
D
G
E
-----
T
I
D
I
D
--
L
K
-
Q
I
N
S
Q
T
----
L
G
L
D
T
L
N
V
---------
Q
-----------
Q
K
Y
K
V
S
D
T
----
A
A
T
V
T
G
Y
A
D
T
T
I
A
L
D
N
S
T
F
K
A
S
A
T
G
L
G
G
T
D
Q
---------
K
I
D
G
-
D
L
K
F
D
D
T
T
G
K
Y
Y
---
A
K
V
T
V
T
G
G
T
G
K
D
G
Y
Y
E
-------------
V
S
V
D
K
T
N
G
E
V
-
T
L
A
G
G
A
T
S
P
L
T
G
G
L
P
A
T
A
T
E
---
D
V
K
N
V
Q
V
A
N
A
D
L
T
E
A
K
A
A
-
L
-----
T
A
A
G
V
T
G
T
A
S
V
V
K
M
S
Y
T
D
N
N
G
K
T
I
D
---------
G
G
L
-----
A
V
K
V
G
D
D
Y
Y
S
A
T
Q
N
K
D
G
S
I
S
I
N
T
T
K
Y
T
A
D
D
G
T
S
K
T
A
L
N
K
L
G
G
A
D
--
G
K
---
T
E
V
V
S
I
G
G
K
T
Y
A
-
A
S
K
A
E
G
H
N
F
--------
K
A
Q
P
D
L
A
E
A
A
A
T
T
T
E
N
P
L
Q
K
I
D
A
A
L
A
Q
---
V
D
T
L
R
-----
S
D
L
G
A
V
Q
N
R
F
N
S
--------------
A
I
T
N
L
G
N
T
V
N
N
L
T
---
S
V
R
S
R
I
E
D
S
D
Y
A
T
E
V
S
N
M
S
R
-
A
Q
I
L
Q
Q
A
G
T
S
V
L
A
Q
A
N
Q
V
P
Q
N
V
L
S
L
L
R
------------------
12
PsiBlast_PDB
52.16
24%
-29
- C3 -
2D4X
-
FLGL_SALTY
A:
[50-138]
-------------------------------------
V
V
L
S
Q
A
Q
A
Q
N
S
Q
Y
A
L
A
R
----------
T
F
A
T
Q
K
V
S
L
E
E
S
V
------
L
S
Q
V
T
T
A
--------------
I
Q
T
A
Q
E
K
I
V
Y
A
G
N
G
T
L
S
D
D
D
R
--------
A
S
L
A
T
D
L
Q
G
I
R
D
Q
L
M
N
L
A
N
S
T
D
G
N
G
R
Y
----
I
F
A
G
Y
K
-----
T
-
E
A
A
P
F
D
Q
A
T
-----
G
G
Y
-----
H
G
G
E
K
--
S
V
-
T
Q
Q
V
D
S
----
A
R
T
M
V
I
G
H
---------
T
-----------
G
A
Q
I
F
N
S
I
----
T
S
N
A
V
P
E
P
D
G
S
D
S
E
K
N
L
F
V
M
L
D
T
A
I
A
A
L
K
T
P
---------
V
E
G
N
-
N
V
E
K
E
K
A
A
A
A
I
D
---
K
T
N
R
G
L
K
N
S
L
N
N
V
L
T
V
-------------
R
A
E
L
G
T
Q
L
S
E
-
L
S
T
L
D
S
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Fugue
51.36
16%
-8
- C2 -
4UMW
2
?
A:
[124-730]
RL
K
E
N
L
P
L
I
T
L
I
V
M
M
A
I
S
W
G
L
E
Q
F
N
H
P
F
G
Q
L
A
F
I
A
T
T
L
V
G
L
Y
P
I
A
R
Q
A
L
R
L
I
K
S
GSYFA
I
E
T
L
M
S
V
A
A
I
G
A
L
F
I
G
A
T
A
E
A
A
M
V
L
L
L
F
L
I
G
E
R
L
E
-
G
W
A
A
S
R
V
S
A
L
M
A
L
K
P
E
T
A
T
R
L
R
N
G
E
R
E
E
V
A
INSLRPG
D
V
I
E
V
A
A
G
G
R
L
P
A
D
G
K
L
L
S
P
F
A
S
F
D
E
S
A
----
L
T
G
E
S
I
P
V
E
R
A
T
-
G
D
K
V
P
A
G
A
T
-----
S
V
D
R
L
V
T
L
E
V
L
S
E
--
P
G
-
A
S
A
I
D
R
----
I
L
K
L
I
E
E
A
---------
E
E
R
R
A
P
I
E
R
F
I
D
R
F
S
R
I
Y
T
P
----
A
I
M
A
V
A
L
L
V
T
L
V
P
P
L
L
F
A
A
S
W
Q
E
W
I
Y
K
G
L
T
L
L
L
I
G
CPCAL
V
I
S
T
-
P
A
A
I
T
S
G
L
A
A
A
A
---
R
R
G
A
L
I
K
G
G
A
A
L
E
Q
L
G
R
VT
Q
V
A
F
D
K
TGTL
T
V
G
K
P
R
V
T
A
I
-
H
P
A
T
G
I
S
E
S
E
L
L
T
L
A
A
A
V
E
Q
---
G
A
T
H
P
L
A
Q
A
I
V
R
E
A
Q
V
A
E
-
L
AIPTA
E
S
Q
R
A
L
V
G
S
G
I
E
A
Q
V
N
G
E
R
V
L
I
C
A
A
GKHPADAF
A
G
L
I
-----
N
E
L
E
S
A
G
Q
T
V
V
L
V
V
R
N
D
D
V
L
G
I
I
A
L
Q
D
T
L
R
A
D
A
A
T
A
I
S
E
L
N
A
L
G
--------
V
K
G
V
I
L
T
G
D
N
P
-
R
A
A
A
A
I
A
G
E
L
G
L
E
F
K
A
G
L
L
P
E
D
K
V
K
A
V
T
K
L
N
Q
H
A
P
L
A
M
V
G
D
G
I
N
D
A
P
A
M
K
A
A
-----
A
I
G
I
A
M
G
S
G
--
T
--------------
D
V
A
L
E
T
A
D
A
A
L
T
H
NH
L
R
G
L
V
Q
M
I
E
L
A
R
A
T
H
A
N
I
R
Q
N
-
I
T
I
A
L
G
L
K
G
I
F
L
V
T
T
L
L
G
M
T
G
L
W
L
A
V
L
A
D
T
G
A
T
V
L
V
T
A
N
A
L
R
L
L
R
18
HHSearch
50.79
28%
-32
- C3 -
1IO1
-
FLIC_SALTY
A:
[56-173]
--------------------------------------------------------------------
N
I
K
G
L
T
Q
A
S
R
N
A
N
D
G
I
S
I
A
Q
T
T
E
G
A
L
-
N
---
E
I
N
N
N
L
Q
R
V
R
E
L
A
V
Q
S
A
N
S
T
N
S
Q
S
D
L
--------
D
S
I
Q
A
E
I
T
Q
R
L
N
E
I
D
R
V
S
G
Q
T
Q
F
N
G
V
K
----
V
L
A
Q
D
N
-----
T
--
L
T
I
Q
V
G
A
N
-----
D
G
E
-----
T
I
D
I
D
--
L
K
-
Q
I
N
S
Q
T
----
L
G
L
D
T
L
N
V
---------
Q
-----------
Q
K
Y
K
V
S
D
T
----
A
A
T
V
T
G
Y
A
D
T
T
I
A
L
D
N
S
T
F
K
A
S
A
T
G
L
G
G
T
D
Q
---------
K
I
D
G
-
D
L
K
F
D
D
T
T
G
K
Y
Y
---
A
K
V
T
V
T
G
G
T
G
K
D
G
Y
Y
E
-------------
V
S
V
D
K
T
N
G
E
V
-
T
L
A
G
G
A
T
S
P
L
T
G
G
L
P
A
T
A
T
E
---
D
V
K
N
V
Q
V
A
N
A
D
L
T
E
A
K
A
A
-
L
-----
T
A
A
G
V
T
G
T
A
S
V
V
K
M
S
Y
T
D
N
N
G
K
T
I
D
---------
G
G
L
-----
A
V
K
V
G
D
D
Y
Y
S
A
T
Q
N
K
D
G
S
I
S
I
N
T
T
K
Y
T
A
D
D
G
T
S
K
T
A
L
N
K
L
G
G
A
D
--
G
K
---
T
E
V
V
S
I
G
G
K
T
Y
A
-
A
S
K
A
E
G
H
N
F
--------
K
A
Q
P
D
L
A
E
A
A
A
T
T
T
E
N
P
L
Q
K
I
D
A
A
L
A
Q
---
V
D
T
L
R
-----
S
D
L
A
A
V
Q
N
R
F
N
S
--------------
A
I
T
N
L
G
N
T
V
N
N
L
T
---
S
A
R
---------------------------------------------------------------
9
PsiBlast_PDB
50.67
31%
-21
- C3 -
4CFI
-
?
A:
[1-108]
---------------------------------------------------------------------------------
D
G
V
S
I
L
Q
T
A
S
S
G
L
-
T
---
S
L
T
N
S
L
Q
R
I
R
Q
L
A
V
Q
A
S
N
G
P
L
S
A
S
D
A
--------
S
A
L
Q
Q
E
V
A
Q
Q
I
S
E
V
N
R
I
A
S
Q
T
N
Y
N
G
K
N
----
I
L
D
G
S
A
-----
G
-
T
L
S
F
Q
V
G
A
N
-----
V
G
Q
-----
T
V
S
V
D
--
L
T
Q
S
M
S
A
A
K
----
I
G
G
G
M
V
Q
T
---------
G
-----------
Q
T
L
G
T
I
K
V
----
A
I
D
S
S
G
A
A
W
S
S
G
S
T
G
Q
E
T
T
Q
I
N
V
V
S
D
G
K
G
G
F
---------
T
F
T
D
-
Q
N
N
Q
A
L
S
S
T
A
V
T
---
A
V
F
G
S
S
T
A
G
T
G
T
A
A
S
P
-------------
S
F
Q
T
L
A
L
S
T
S
-
A
T
S
A
L
S
A
T
D
Q
A
N
A
T
A
M
V
A
Q
I
---
N
A
V
N
K
P
Q
T
V
S
N
L
D
I
S
T
Q
T
-
G
-----
A
Y
Q
A
M
V
S
I
D
N
A
L
A
T
V
N
N
L
Q
A
T
L
G
A
A
---------
Q
N
R
-----
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
50.56
36%
-15
- C3 -
3V47
-
FLIC_SALDU
C:
[24-115]
----------------------------------------------------------------------------
S
R
N
A
N
D
G
I
S
I
A
Q
T
T
E
G
A
L
-
N
---
E
I
N
N
N
L
Q
R
V
R
E
L
S
V
Q
A
T
N
G
T
N
S
D
S
D
L
--------
K
S
I
Q
D
E
I
Q
Q
R
L
E
E
I
D
R
V
S
N
Q
T
Q
F
N
G
V
K
----
V
L
S
Q
D
N
-----
Q
-
M
K
-
I
Q
V
G
A
N
-----
D
G
E
-----
T
I
T
I
D
--
L
Q
-
K
I
D
V
K
S
----
L
G
L
D
G
F
N
V
---------
N
-----------
G
P
K
E
A
T
V
G
----
D
L
K
S
S
F
K
N
V
T
G
Y
D
T
Y
A
A
G
A
D
K
Y
R
V
D
I
N
S
G
A
V
---------
V
T
D
A
-
V
A
P
D
K
V
Y
V
N
A
A
N
---
G
Q
L
T
T
D
D
A
E
N
N
T
K
T
K
N
-------------
E
S
A
K
L
S
D
L
E
A
-
N
N
A
V
K
G
E
S
K
I
T
V
N
G
A
E
Y
T
A
N
---
A
T
G
D
K
I
T
L
A
G
K
T
M
F
I
D
K
T
-
A
-----
S
G
V
S
T
L
I
N
E
D
A
A
A
A
K
K
S
T
A
N
P
L
A
S
I
---------
D
S
A
-----
L
S
K
V
D
A
V
R
S
S
L
G
A
I
Q
N
R
F
D
S
A
I
T
N
L
G
N
T
V
T
N
L
N
S
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
48.66
35%
-5
- C3 -
3V47
-
FLIC_SALDU
C:
[24-101]
----------------------------------------------------------------------------
S
R
N
A
N
D
G
I
S
I
A
Q
T
T
E
G
A
L
-
N
---
E
I
N
N
N
L
Q
R
V
R
E
L
S
V
Q
A
T
N
G
T
N
S
D
S
D
L
--------
K
S
I
Q
D
E
I
Q
Q
R
L
E
E
I
D
R
V
S
N
Q
T
Q
F
N
G
V
K
----
V
L
S
Q
D
N
-----
Q
-
M
K
I
Q
V
G
A
N
D
-----
G
E
T
-----
I
T
I
D
L
--
Q
K
-
I
D
V
K
S
L
----
G
L
D
G
F
N
V
N
---------
G
-----------
P
K
E
A
T
V
G
D
----
L
K
S
S
F
K
N
V
T
G
Y
D
T
Y
A
A
G
A
D
K
Y
R
V
D
I
N
S
G
A
V
V
---------
T
D
A
V
-
A
P
D
K
V
Y
V
N
A
A
N
G
---
Q
L
T
T
D
D
A
E
N
N
T
K
T
K
N
E
-------------
S
A
K
L
S
D
L
E
A
N
-
N
A
V
K
G
E
S
K
I
T
V
N
G
A
E
Y
T
A
N
A
---
T
G
D
K
I
T
L
A
G
K
T
M
F
I
D
K
T
A
-
S
-----
G
V
S
T
L
I
N
E
D
A
A
A
A
K
K
S
T
A
N
P
L
A
S
I
D
---------
S
A
L
-----
S
K
V
D
A
V
R
S
S
L
G
A
I
Q
N
R
F
D
S
A
I
T
N
L
G
N
T
V
T
N
L
N
S
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
HHSearch
46.21
23%
23
- C3 -
2D4X
-
FLGL_SALTY
A:
[50-148]
-----------------------------------------------------
V
----------
V
L
S
Q
A
Q
A
Q
N
S
Q
Y
A
L
A
R
T
F
A
T
Q
K
V
S
L
E
E
S
V
L
-
S
---
Q
V
T
T
A
I
Q
T
A
Q
E
K
I
V
Y
A
G
N
G
T
L
S
D
D
D
R
--------
A
S
L
A
T
D
L
Q
G
I
R
D
Q
L
M
N
L
A
N
S
T
D
G
N
G
R
Y
----
I
F
A
G
Y
K
-----
T
E
A
A
P
F
D
Q
A
T
G
-----
G
Y
H
-----
G
G
E
K
S
--
V
T
-
Q
Q
V
D
S
A
----
R
T
M
V
I
G
H
T
---------
G
-----------
A
Q
I
F
N
S
I
T
----
S
N
A
V
P
E
P
D
G
S
D
S
E
K
N
L
F
V
M
L
D
T
A
I
A
A
L
K
T
P
V
---------
E
G
N
N
-
V
E
K
E
K
A
A
A
A
I
D
K
---
T
N
R
G
L
K
N
S
L
N
N
V
L
T
V
R
-------------
A
E
L
G
T
Q
L
S
E
L
-
S
T
L
D
S
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
45.05
13%
21
- C3 -
3PWX
1
?
A:
[2-113]
-----------------------------------------
S
L
S
D
D
P
M
A
S
I
K
L
L
----------
N
L
E
R
E
N
S
A
I
A
Q
Y
Q
S
N
I
A
N
L
K
T
T
L
S
S
Q
E
T
H
L
-
D
---
S
V
S
E
S
L
K
S
M
R
D
I
V
L
W
G
A
N
G
S
L
T
D
Q
D
R
--------
S
G
M
I
T
E
L
K
S
Y
R
D
S
I
E
S
S
F
N
A
Q
D
E
E
G
H
F
----
L
F
S
G
T
K
-----
T
D
T
A
A
L
N
K
S
S
G
-----
A
Y
V
-----
V
E
G
N
S
--
D
V
-
R
V
V
T
V
A
----
K
G
V
T
M
D
S
N
---------
M
-----------
T
A
Q
E
I
L
D
I
----
G
G
G
K
N
V
L
N
Q
I
D
A
L
I
A
E
F
E
K
P
S
P
N
F
Q
A
E
V
D
A
S
---------
L
N
A
I
-
D
D
T
M
A
N
V
L
G
A
M
T
---
E
I
G
G
R
H
N
N
L
D
L
M
D
G
A
H
-------------
S
E
N
K
L
F
V
D
K
V
-
S
G
D
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
43.61
14%
7
- C3 -
3K1I
-
?
C:
[28-97]
-------------------------------------------------------------------
Q
Q
I
A
K
F
S
R
D
M
K
N
I
N
E
S
V
G
A
L
Q
V
L
Q
I
A
C
-
K
---
K
L
F
N
K
S
M
G
L
E
D
K
D
A
------------------------
L
Q
A
S
I
I
K
Q
E
L
R
E
I
V
E
N
C
Q
F
L
A
S
P
----
L
F
D
T
Q
L
-----
N
-
I
A
I
N
D
E
I
F
S
-----
M
I
V
-----
V
N
P
L
D
--
L
L
-
E
N
V
G
E
F
----
Q
A
Y
L
E
E
K
L
---------
N
-----------
E
I
K
E
L
L
G
Y
----
L
S
E
S
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------