@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0170: (2015-12-13 )
MFSNQYIQQRIHKANSLREEGKNPYKNGLKRSLTNAAFLEKYAYVKGLEEPKDKEKCESVVGRVKLLRLMGKACFIKIEDESAILQAYVSQNELNDEFKSLKKHLEVGDIVLVKGFPFATKTGELSIHALEFHILSKTIVPLPEKFHGLSDIELRYRQRYLDLIVNPGVKDVFKKRSLIVSSVRKFFEMEGFLEVETPMMHPIPGGANARPFITYHNALEIERYLRIAPELYLKRLIVGGFEAVFEINRNFRNEGMDHSHNPEFTMIEFYWAYHTYEDLIELSKRLFDYLLKTLNLDSKIIYNDMEVDFNQTSVISYLDALETIGGISKGILEKEDRLLAYLLEQGIKVEPNLTHGKLLAEAFDHFVEHKLINPTFVTEYPIEISPLARRNDSNPNIADRFELFIAGKEIANGFSELNDPLDQLERFKNQVAEKEKGDEEAQYMDEDYVWALAHEMPPTAGQGIGIDRLVMLLTGAKSIKDVILFPAMRPVKNDFNVEGEE
Atome Classification :
(25 SA)
.........10........20........30........40........50..--.....-.------60........70-........80........90...-----.----....-100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200------.-........210....----...220.......230.......240.......250.......260.......270.-......280.......290.....-------..300..-------.---....310--------.--.-.......320...-.----..---.-330.....---..340.......-350--........360.......370-........380....-...390.......400.......410.......420.......430...-....440.......450.......460.......470.......480.......490.......500
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MF
S
N
Q
Y
I
Q
Q
R
I
H
K
A
N
S
L
R
E
EGK
N
P
Y
K
N
G
L
K
R
SL
T
N
A
A
F
L
E
K
Y
A
Y
V
KGLEEPK
D
--
K
E
K
C
E
-
S
------
V
V
G
R
V
K
L
L
R
L
MG-
K
A
C
F
I
K
IED
E
S
A
I
L
Q
A
Y
V
S
Q
N
E
L
-----
N
----
D
E
F
K
-
S
L
K
K
HLEVG
D
I
V
L
VKGFPFATKTG
E
L
S
I
H
A
L
E
F
H
I
L
S
K
TIVPL
P
E
K
FHGL
S
D
I
E
L
R
Y
R
Q
R
Y
L
D
L
IVNP
G
V
K
D
V
F
K
K
R
S
L
I
V
S
S
V
R
K
F
F
E
ME
G
F
L
E
VETPMM--------H-PIPGGANA
R
P
F
I
T
YH----
N
A
L
E
I
E
R
Y
L
RI
A
P
E
L
Y
L
K
R
L
I
V
G
G
F
E
A
V
F
E
I
N
R
N
FRNEGMDHSHNPE
F
T
M
I
E
F
Y
W
A
Y
-
H
T
Y
E
D
L
I
E
L
S
K
R
L
F
D
Y
L
L
K
TLNLD-------S
K
I
I
Y
ND-------
M
---
E
VDF
N
----------
Q
--
T
-
S
V
I
S
Y
L
D
A
L
E
T
I
G
-
G
----
I
S
---
K
-
G
I
LEK
E
D
R
---
L
L
A
Y
L
L
EQGIKV-EP---NLT
H
G
K
L
L
A
E
A
F
D
H
F
V
E
H
KL--IN
P
T
F
V
T
EYPIEISP-LARRNDSNP
N
I
A
D
R
F
E
L
F
IA
G
K
E
I
A
N
G
F
S
E
LN
D
P
L
D
Q
L
E
R
F
K
N
Q
VAEKE-KGD
E
E
A
Q
Y
M
D
E
D
Y
V
W
A
L
A
HEMPPTAGQGI
G
I
D
R
L
V
M
L
L
TG
A
K
S
I
K
D
V
ILFPAMRPVKNDFNVEGEE
11
PsiBlast_PDB
96.45
47%
-80
- C7 -
4EX5
1
SYK_BURTA
A:
[37-526]
---
N
Q
I
V
A
E
R
R
D
K
L
R
A
L
R
D
Q
G
I
A
-
Y
P
N
D
F
Q
P
T
-
H
H
A
A
D
L
Q
T
-
A
Y
A
D
A
D
K
E
A
L
E
--
A
K
S
L
E
V
A
------
I
A
G
R
M
M
L
K
R
V
M
G
-
K
A
S
F
A
T
V
Q
D
G
S
G
Q
I
Q
F
F
V
T
P
A
D
V
-----
G
----
A
E
T
Y
-
D
A
F
K
K
W
D
L
G
D
I
V
A
A
R
G
V
L
F
R
T
N
K
G
E
L
S
V
K
C
T
Q
L
R
L
L
A
K
A
L
R
P
L
P
D
------
D
Q
E
T
R
Y
R
Q
R
Y
V
D
L
I
V
T
P
E
T
R
T
T
F
R
A
R
T
K
A
I
A
S
I
R
K
F
M
G
D
A
D
F
M
E
V
E
T
P
M
L
--------
H
-
P
I
P
G
G
A
A
A
K
P
F
V
T
H
H
----
N
A
L
D
M
E
M
F
L
R
I
A
P
E
L
Y
L
K
R
L
I
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
V
S
P
R
H
N
P
E
F
T
M
M
E
F
Y
A
A
Y
-
T
D
Y
R
W
L
M
D
F
T
E
R
L
I
R
Q
A
A
V
D
A
L
G
T
-------
A
T
I
Q
Y
Q
G
-------
R
---
E
L
D
L
A
----------
Q
--
P
F
H
R
L
T
I
T
Q
A
I
Q
K
Y
A
P
S
----
Y
T
---
D
-
G
Q
L
S
D
D
A
F
---
L
R
S
E
L
K
R
L
G
V
D
V
T
Q
P
AFL
N
A
G
I
G
A
L
Q
L
A
L
F
E
E
T
A
E
A
Q
L
--
W
E
P
T
F
I
I
D
Y
P
I
E
V
S
P
-
L
A
R
E
S
D
T
V
A
G
I
T
E
R
F
E
L
F
I
T
G
R
E
I
A
N
G
F
S
E
L
N
D
P
E
D
Q
A
A
R
F
K
K
Q
V
E
Q
K
D
-
A
G
D
E
E
A
M
F
F
D
A
D
Y
I
R
A
L
E
Y
G
M
P
P
T
G
G
C
G
I
G
I
D
R
L
V
M
L
L
T
D
S
P
T
I
R
D
V
L
L
F
P
H
L
R
R
-----------
3
PsiBlast_PDB
96.35
49%
-87
- C7 -
1LYL
1
SYK2_ECOLI
A:
[15-502]
---
N
D
E
L
R
N
R
R
E
K
L
A
A
L
R
Q
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
-------
D
A
K
D
--
N
Q
E
L
E
-
S
L
NI
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
-
K
A
S
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
A
R
D
S
L
PEGVY
N
----
D
Q
F
K
-
K
W
----
D
L
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
--------
Q
-
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
----
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
-
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
G
T
-------
T
K
V
T
Y
G
E
-------
H
---
V
F
D
F
G
----------
K
--
P
---
F
E
K
L
T
M
R
E
A
I
K
-
K
Y
R
PE
T
D
---
M
-
A
D
L
D
N
F
D
A
---
A
K
A
L
A
E
S
I
G
I
T
V
-
E
K
---
S
W
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
--
I
Q
P
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
V
N
A
K
A
-
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
P
-----------
4
PsiBlast_PDB
96.19
49%
-89
- C7 -
1E1O
9
SYK2_ECOLI
A:
[15-502]
---
N
D
E
L
R
N
R
R
E
K
L
A
A
L
R
Q
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
-------
D
A
K
D
--
N
Q
E
L
E
-
S
L
N
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
-
K
A
S
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
A
R
D
S
L
PEGVY
N
----
D
Q
F
K
-
K
W
----
D
L
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
--------
Q
-
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
----
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
-
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
-
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
G
T
-------
T
K
V
T
Y
G
E
-------
H
---
V
F
D
F
G
----------
K
--
P
---
F
E
K
L
T
M
R
E
A
I
K
-
K
Y
R
PE
T
D
---
M
-
A
D
L
D
N
F
D
A
---
A
K
A
L
A
E
S
I
G
I
T
V
-
E
K
---
S
W
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
--
I
Q
P
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
V
N
A
K
A
-
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
P
-----------
21
PsiBlast_CBE
95.93
49%
-89
- C7 -
1LYL
1
SYK2_ECOLI
C:
[15-502]
---
N
D
E
L
R
N
R
R
E
K
L
A
A
L
R
Q
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
-------
D
A
K
D
--
N
Q
E
L
E
-
S
LNIEVS
V
A
G
R
M
M
T
R
R
I
M
G
-
K
A
S
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
A
R
D
S
L
PEGVY
N
----
D
Q
F
K
-
K
W
----
D
L
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
--------
Q
-
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
----
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
-
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
G
T
-------
T
K
V
T
Y
G
E
-------
H
---
V
F
D
F
G
----------
K
--
P
---
F
E
K
L
T
M
R
E
A
I
K
-
K
YRPE
T
D
---
M
-
A
D
L
D
N
F
D
A
---
A
K
A
L
A
E
S
I
G
I
T
V
-
E
K
---
S
W
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
--
I
Q
P
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
V
N
A
K
A
-
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
P
-----------
74
HHSearch
95.54
50%
-80
- C7 -
1E1O
9
SYK2_ECOLI
A:
[14-502]
--
F
N
D
E
L
R
N
R
R
E
K
L
A
A
L
R
Q
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
-
E
S
--
L
N
I
E
V
-
S
------
V
A
G
R
M
M
T
R
R
I
M
G
-
K
A
S
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
A
R
D
S
L
-----
P
----
E
G
V
Y
N
D
Q
F
K
K
W
D
L
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
--------
Q
-
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
----
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
-
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
-
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
G
T
-------
T
K
V
T
Y
G
E
-------
H
---
V
F
D
F
G
----------
K
P-
F
-
E
K
L
T
M
R
E
A
I
K
K
Y
R
-
P
----
E
T
---
D
M
A
D
L
D
N
F
D
A
---
A
K
A
L
A
E
S
I
G
I
T
V
-
E
K
---
S
W
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
--
I
Q
P
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
V
N
A
K
A
-
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
P
-----------
6
PsiBlast_PDB
95.44
49%
-85
- C7 -
1E22
11
SYK2_ECOLI
A:
[15-502]
---
N
D
E
L
R
N
R
R
E
K
L
A
A
L
R
Q
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
-------
D
A
K
D
--
N
Q
E
L
E
-
S
L
N
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
-
K
A
S
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
A
R
D
S
L
PEGVY
N
----
D
Q
F
K
-
K
W
----
D
L
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
--------
Q
-
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
----
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
-
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
G
T
-------
T
K
V
T
Y
G
E
-------
H
---
V
F
D
F
G
----------
K
--
P
---
F
E
K
L
T
M
R
E
A
I
K
-
K
Y
R
PE
T
D
---
M
-
A
D
L
D
N
F
D
A
---
A
K
A
L
A
E
S
I
G
I
T
V
-
E
K
---
S
W
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
--
I
Q
P
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
V
N
A
K
A
-
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
P
-----------
2
PsiBlast_PDB
95.40
50%
-100
- C7 -
1BBW
-
SYK1_ECOLI
A:
[15-502]
---
N
N
E
L
K
T
R
R
E
K
L
A
N
L
R
E
Q
G
I
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
A
E
F
-------
D
G
K
E
--
N
E
E
L
E
-
A
L
N
I
E
V
A
V
A
G
R
M
M
T
R
R
I
M
G
-
K
A
S
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
A
R
D
D
L
PEGVY
N
----
E
Q
F
K
-
K
W
----
D
L
G
D
I
L
G
A
K
G
K
L
F
K
T
K
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
A
R
Y
R
Q
R
Y
L
D
L
I
S
N
D
E
S
R
N
T
F
K
V
R
S
Q
I
L
S
G
I
R
Q
F
M
V
N
R
G
F
M
E
V
E
T
P
M
M
--------
Q
-
V
I
P
---
A
A
R
P
F
I
T
H
H
----
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
-
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
-
A
D
Y
K
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
D
I
L
G
K
-------
T
E
V
T
Y
G
D
-------
V
---
T
L
D
F
G
----------
K
--
P
---
F
E
K
L
T
M
R
E
A
I
K
-
K
Y
R
PE
T
D
---
M
-
A
D
L
D
N
F
D
S
---
A
K
A
I
A
E
S
I
G
I
H
V
-
E
K
---
S
W
G
L
G
R
I
V
T
E
I
F
E
E
V
A
E
A
H
L
--
I
Q
P
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
Q
R
F
L
D
Q
V
-------------
Y
D
E
D
Y
V
T
A
L
E
H
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
V
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
P
-----------
22
PsiBlast_CBE
95.30
49%
-86
- C7 -
1LYL
1
SYK2_ECOLI
B:
[15-502]
---
N
D
E
L
R
N
R
R
E
K
L
A
A
L
R
Q
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
-------
D
A
K
D
--
N
Q
E
L
E
-
S
L
NI
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
-
K
A
S
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
A
R
D
S
L
PEGVY
N
----
D
Q
F
K
-
K
W
----
D
L
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
------
D
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
--------
Q
-
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
----
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
-
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
G
T
-------
T
K
V
T
Y
G
E
-------
H
---
V
F
D
F
G
----------
K
--
P
---
F
E
K
L
T
M
R
E
A
I
K
-
K
Y
R
PE
T
D
---
M
-
A
D
L
D
N
F
D
A
---
A
K
A
L
A
E
S
I
G
I
T
V
-
E
K
---
S
W
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
--
I
Q
P
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
V
N
A
K
A
-
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
P
-----------
32
PsiBlast_CBE
95.25
47%
-81
- C7 -
4EX5
1
SYK_BURTA
B:
[37-526]
---
N
Q
I
V
A
E
R
R
D
K
L
R
A
L
R
D
Q
G
I
A
-
Y
P
N
D
F
Q
P
T
-
H
H
A
A
D
L
Q
T
-
A
Y
A
D
A
D
K
E
A
L
E
--
A
K
S
L
E
V
A
------
I
A
G
R
M
M
L
K
R
V
M
G
-
K
A
S
F
A
T
V
Q
D
G
S
G
Q
I
Q
F
F
V
T
P
A
D
V
-----
G
----
A
E
T
Y
-
D
A
F
K
K
W
D
L
G
D
I
V
A
A
R
G
V
L
F
R
T
N
K
G
E
L
S
V
K
C
T
Q
L
R
L
L
A
K
A
L
R
P
L
P
D
-------
Q
E
T
R
Y
R
Q
R
Y
V
D
L
I
V
T
P
E
T
R
T
T
F
R
A
R
T
K
A
I
A
S
I
R
K
F
M
G
D
A
D
F
M
E
V
E
T
P
M
L
--------
H
-
P
I
P
G
G
A
A
A
K
P
F
V
T
H
H
----
N
A
L
D
M
E
M
F
L
R
I
A
P
E
L
Y
L
K
R
L
I
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
V
S
P
R
H
N
P
E
F
T
M
M
E
F
Y
A
A
Y
-
T
D
Y
R
W
L
M
D
F
T
E
R
L
I
R
Q
A
A
V
D
A
L
G
T
-------
A
T
I
Q
Y
Q
G
-------
R
---
E
L
D
L
A
----------
Q
--
P
F
H
R
L
T
I
T
Q
A
I
Q
K
Y
A
P
S
----
Y
T
---
D
-
G
Q
L
S
D
D
A
F
---
L
R
S
E
L
K
R
L
G
V
D
V
T
Q
P
AFL
N
A
G
I
G
A
L
Q
L
A
L
F
E
E
T
A
E
A
Q
L
--
W
E
P
T
F
I
I
D
Y
P
I
E
V
S
P
-
L
A
R
E
S
D
T
V
A
G
I
T
E
R
F
E
L
F
I
T
G
R
E
I
A
N
G
F
S
E
L
N
D
P
E
D
Q
A
A
R
F
K
K
Q
V
E
Q
K
D
-
A
G
D
E
E
A
M
F
F
D
A
D
Y
I
R
A
L
E
Y
G
M
P
P
T
G
G
C
G
I
G
I
D
R
L
V
M
L
L
T
D
S
P
T
I
R
D
V
L
L
F
P
H
L
R
R
-----------
7
PsiBlast_PDB
95.09
49%
-88
- C7 -
1E24
7
SYK2_ECOLI
A:
[15-502]
---
N
D
E
L
R
N
R
R
E
K
L
A
A
L
R
Q
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
-------
D
A
K
D
--
N
Q
E
L
E
-
S
L
N
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
-
K
A
S
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
A
R
D
S
L
PEGVY
N
----
D
Q
F
K
-
K
W
----
D
L
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
--------
Q
-
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
----
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
-
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
G
T
-------
T
K
V
T
Y
G
E
-------
H
---
V
F
D
F
G
----------
K
--
P
---
F
E
K
L
T
M
R
E
A
I
K
-
K
Y
R
PE
T
D
---
M
-
A
D
L
D
N
F
D
A
---
A
K
A
L
A
E
S
I
G
I
T
V
-
E
K
---
S
W
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
--
I
Q
P
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
V
N
A
K
A
-
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
P
-----------
63
Fugue
94.95
50%
-84
- C7 -
1LYL
1
SYK2_ECOLI
A:
[14-502]
--
F
N
D
E
L
R
N
R
R
E
K
L
A
A
L
R
Q
Q
G
-
V
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
-
K
D
N
Q
E
L
E
S
--
L
N
I
E
V
-
S
------
V
A
G
R
M
M
T
R
R
I
M
G
-
K
A
S
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
A
R
--------
D
SLPE
G
V
Y
N
-
D
Q
F
K
K
W
D
L
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
-------
D
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
--------
Q
-
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
----
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A-
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
G
--------------------------
T
T
K
V
T
Y
GE
H
V
F
D
FG
K
P
--
F
-
E
K
L
T
M
R
E
A
I
K
K
Y
R
P
E
----
T
D
---
M
-
A
D
L
D
N
F
D
A
---
A
K
A
L
A
E
S
I
G
I
T
V
-
E
K
---
S
W
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
--
I
Q
P
T
F
I
T
E
Y
P
A
E
V
S
-P
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
V
N
A
K
A
-
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
P
-----------
9
PsiBlast_PDB
94.74
47%
-72
- C7 -
3E9I
4
SYK_GEOSE
A:
[6-491]
---
N
D
Q
L
R
V
R
R
E
K
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
-
E
E
L
E
E
--
Q
Q
I
E
V
-
A
------
V
A
G
R
I
M
T
K
R
G
M
G
-
K
A
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
Q
D
D
V
-----
G
----
E
Q
Q
Y
-
E
L
F
K
I
S
D
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
--------
H
-
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
----
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
-
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
G
T
-------
T
K
I
Q
Y
G
E
-------
H
---
L
V
D
L
T
P---------
E
--
W
-
R
R
L
H
M
V
D
A
I
K
E
Y
V
-
G
----
V
D
FW-
R
-
Q
M
S
D
E
E
A
R
---
E
L
A
K
--
E
H
G
V
E
V
-
A
P
---
H
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
--
I
Q
P
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
-
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
-----------
5
PsiBlast_PDB
94.55
49%
-85
- C7 -
1E1T
11
SYK2_ECOLI
A:
[15-502]
---
N
D
E
L
R
N
R
R
E
K
L
A
A
L
R
Q
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
-------
D
A
K
D
--
N
Q
E
L
E
-
S
L
N
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
-
K
A
S
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
A
R
D
S
L
PEGVY
N
----
D
Q
F
K
-
K
W
----
D
L
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
--------
Q
-
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
----
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
-
A
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
L
G
T
-------
T
K
V
T
Y
G
E
-------
H
---
V
F
D
F
G
----------
K
--
P
---
F
E
K
L
T
M
R
E
A
I
K
-
K
Y
R
PE
T
D
---
M
-
A
D
L
D
N
F
D
A
---
A
K
A
L
A
E
S
I
G
I
T
V
-
E
K
---
S
W
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
--
I
Q
P
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
V
N
A
K
A
-
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
P
-----------
8
PsiBlast_PDB
94.43
47%
-71
- C7 -
3E9H
2
SYK_GEOSE
A:
[6-491]
---
N
D
Q
L
R
V
R
R
E
K
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
-
E
E
L
E
E
--
Q
Q
I
E
V
-
A
------
V
A
G
R
I
M
T
K
R
G
M
G
-
K
A
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
Q
D
D
V
-----
G
----
E
Q
Q
Y
-
E
L
F
K
I
S
D
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
--------
H
-
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
----
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
-
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
G
T
-------
T
K
I
Q
Y
G
E
-------
H
---
L
V
D
L
T
P---------
E
--
W
-
R
R
L
H
M
V
D
A
I
K
E
Y
V
-
G
----
V
D
FW-
R
-
Q
M
S
D
E
E
A
R
---
E
L
A
K
--
E
H
G
V
E
V
-
A
P
---
H
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
--
I
Q
P
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
-
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
-----------
10
PsiBlast_PDB
94.08
47%
-74
- C7 -
3A74
5
SYK_GEOSE
A:
[6-491]
---
N
D
Q
L
R
V
R
R
E
K
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
-
E
E
L
E
E
--
Q
Q
I
E
V
-
A
------
V
A
G
R
I
M
T
K
R
G
M
G
-
K
A
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
Q
D
D
V
-----
G
----
E
Q
Q
Y
-
E
L
F
K
I
S
D
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
--------
H
-
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
----
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
-
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
G
T
-------
T
K
I
Q
Y
G
E
-------
H
---
L
V
D
L
T
P---------
E
--
W
-
R
R
L
H
M
V
D
A
I
K
E
Y
V
-
G
----
V
D
FW-
R
-
Q
M
S
D
E
E
A
R
---
E
L
A
K
--
E
H
G
V
E
V
-
A
P
---
H
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
--
I
Q
P
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
-
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
-----------
1
PsiBlast_PDB
94.08
50%
-84
- C7 -
1BBU
1
SYK1_ECOLI
A:
[15-502]
---
N
N
E
L
K
T
R
R
E
K
L
A
N
L
R
E
Q
G
I
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
A
E
F
-------
D
G
K
E
--
N
E
E
L
E
-
A
L
N
I
E
V
A
V
A
G
R
M
M
T
R
R
I
M
G
-
K
A
S
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
A
R
D
D
L
PEGVY
N
----
E
Q
F
K
-
K
W
----
D
L
G
D
I
L
G
A
K
G
K
L
F
K
T
K
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
------
D
Q
E
A
R
Y
R
Q
R
Y
L
D
L
I
S
N
D
E
S
R
N
T
F
K
V
R
S
Q
I
L
S
G
I
R
Q
F
M
V
N
R
G
F
M
E
V
E
T
P
M
M
--------
Q
-
V
I
P
G
G
A
A
A
R
P
F
I
T
H
H
----
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
-
A
D
Y
K
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
D
I
L
G
K
-------
T
E
V
T
Y
G
D
-------
V
---
T
L
D
F
G
----------
K
--
P
---
F
E
K
L
T
M
R
E
A
I
K
-
K
Y
R
PE
T
D
---
M
-
A
D
L
D
N
F
D
S
---
A
K
A
I
A
E
S
I
G
I
H
V
-
E
K
---
S
W
G
L
G
R
I
V
T
E
I
F
E
E
V
A
E
A
H
L
--
I
Q
P
T
F
I
T
E
Y
P
A
E
V
S
P
-
L
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
Q
R
F
L
D
Q
V
A
A
K
D
-
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
H
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
V
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
P
-----------
24
PsiBlast_CBE
93.80
47%
-72
- C7 -
3E9I
4
SYK_GEOSE
C:
[6-491]
---
N
D
Q
L
R
V
R
R
E
K
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
-
E
E
L
E
E
--
Q
Q
I
E
V
-
A
------
V
A
G
R
I
M
T
K
R
G
M
G
-
K
A
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
Q
D
D
V
-----
G
----
E
Q
Q
Y
-
E
L
F
K
I
S
D
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
--------
H
-
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
----
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
-
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
G
T
-------
T
K
I
Q
Y
G
E
-------
H
---
L
V
D
L
T
P---------
E
--
W
-
R
R
L
H
M
V
D
A
I
K
E
Y
V
-
G
----
V
D
FW-
R
-
Q
M
S
D
E
E
A
R
---
E
L
A
K
--
E
H
G
V
E
V
-
A
P
---
H
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
--
I
Q
P
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
-
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
-----------
23
PsiBlast_CBE
93.69
47%
-75
- C7 -
3E9I
4
SYK_GEOSE
D:
[6-491]
---
N
D
Q
L
R
V
R
R
E
K
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
-
E
E
L
E
E
--
Q
Q
I
E
V
-
A
------
V
A
G
R
I
M
T
K
R
G
M
G
-
K
A
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
Q
D
D
V
-----
G
----
E
Q
Q
Y
-
E
L
F
K
I
S
D
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
--------
H
-
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
----
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
-
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
G
T
-------
T
K
I
Q
Y
G
E
-------
H
---
L
V
D
L
T
P---------
E
--
W
-
R
R
L
H
M
V
D
A
I
K
E
Y
V
-
G
----
V
D
FW-
R
-
Q
M
S
D
E
E
A
R
---
E
L
A
K
--
E
H
G
V
E
V
-
A
P
---
H
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
--
I
Q
P
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
-
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
-----------
30
PsiBlast_CBE
93.54
47%
-74
- C7 -
3A74
5
SYK_GEOSE
C:
[6-491]
---
N
D
Q
L
R
V
R
R
E
K
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
-
E
E
L
E
E
--
Q
Q
I
E
V
-
A
------
V
A
G
R
I
M
T
K
R
G
M
G
-
K
A
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
Q
D
D
V
-----
G
----
E
Q
Q
Y
-
E
L
F
K
I
S
D
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
--------
H
-
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
----
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
-
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
G
T
-------
T
K
I
Q
Y
G
E
-------
H
---
L
V
D
L
T
P---------
E
--
W
-
R
R
L
H
M
V
D
A
I
K
E
Y
V
-
G
----
V
D
FW-
R
-
Q
M
S
D
E
E
A
R
---
E
L
A
K
--
E
H
G
V
E
V
-
A
P
---
H
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
--
I
Q
P
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
-
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
-----------
26
PsiBlast_CBE
93.50
47%
-75
- C7 -
3E9H
2
SYK_GEOSE
D:
[6-491]
---
N
D
Q
L
R
V
R
R
E
K
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
-
E
E
L
E
E
--
Q
Q
I
E
V
-
A
------
V
A
G
R
I
M
T
K
R
G
M
G
-
K
A
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
R
Q
D
D
V
-----
G
----
E
Q
Q
Y
-
E
L
F
K
I
S
D
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
--------
H
-
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
----
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
-
A
D
F
R
D
I
M
K
L
T
E
N
L
I
A
H
I
A
T
E
V
L
G
T
-------
T
K
I
Q
Y
G
E
-------
H
---
L
V
D
L
T
P---------
E
--
W
-
R
R
L
H
M
V
D
A
I
K
E
Y
V
-
G
----
V
D
FW-
R
-
Q
M
S
D
E
E
A
R
---
E
L
A
K
--
E
H
G
V
E
V
-
A
P
---
H
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
--
I
Q
P
T
F
I
Y
G
H
P
V
E
I
S
P
-
L
A
K
K
N
P
D
D
P
R
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
L
K
E
R
E
-
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
H
-----------
36
PsiBlast_CBE
91.12
40%
-81
- C7 -
4YCU
4
SYK_HUMAN
B:
[6-507]
---
N
Q
Y
Y
K
I
R
S
Q
A
I
H
Q
L
K
V
N
G
E
D
P
Y
P
H
K
F
H
V
D
I
S
L
T
D
F
I
Q
K
Y
S
H
L
----
Q
P
G
D
HL
T
D
I
T
L
-
K
------
V
A
G
R
I
H
A
K
R
A
S
G
G
K
L
I
F
Y
D
L
R
G
E
G
V
K
L
Q
V
M
A
N
S
R
N
Y
-----
K
S
E
--
E
E
F
I
-
H
I
N
N
K
L
R
R
G
D
I
I
G
V
Q
G
N
P
G
K
T
K
K
G
E
L
S
I
I
P
Y
E
I
T
L
L
S
P
C
L
H
M
L
P
H
L
-----
D
K
E
T
R
Y
R
Q
R
Y
L
D
L
I
L
N
D
F
V
R
Q
K
F
I
I
R
S
K
I
I
T
Y
I
R
S
F
L
D
E
L
G
F
L
E
I
E
T
P
M
M
--------
N
-
I
I
P
G
G
A
V
A
K
P
F
I
T
Y
H
----
N
E
L
D
M
N
L
Y
M
R
I
A
P
E
L
Y
H
K
M
L
V
V
G
G
I
D
R
V
Y
E
I
G
R
Q
F
R
N
E
G
I
D
L
T
H
N
P
E
F
T
T
C
E
F
Y
M
A
Y
-
A
D
Y
H
D
L
M
E
I
T
E
K
M
V
S
G
M
V
K
H
I
T
G
S
-------
Y
K
V
T
Y
H
P
DGPE
G
Q
A
Y
---
D
V
D
F
T
----------
P
--
P
F
R
R
I
N
M
V
E
E
L
E
K
A
L
-
G
----
M
K
LPE
T
-
N
L
F
E
T
E
E
T
R
K
I
L
D
D
I
C
V
A
K
A
V
E
C
-
P
P
---
P
R
T
T
A
R
L
L
D
K
L
V
G
E
F
L
E
V
T
C
--
I
N
P
T
F
I
C
D
H
P
Q
I
M
S
P
-
L
A
K
W
H
R
S
K
E
G
L
T
E
R
F
E
L
F
V
M
K
K
E
I
C
N
A
Y
T
E
L
N
D
P
M
R
Q
R
Q
L
F
E
E
Q
A
K
A
K
A
-
A
G
D
D
E
A
M
F
I
D
E
N
F
C
T
A
L
E
Y
G
L
P
P
T
A
G
W
G
M
G
I
D
R
V
A
M
F
L
T
D
S
N
N
I
K
E
V
L
L
F
P
A
M
K
P
-----------
14
PsiBlast_PDB
90.36
40%
-78
- C7 -
4YCU
4
SYK_HUMAN
A:
[6-507]
---
N
Q
Y
Y
K
I
R
S
Q
A
I
H
Q
L
K
V
N
G
E
D
P
Y
P
H
K
F
H
V
D
I
S
L
T
D
F
I
Q
K
Y
S
H
L
----
Q
P
G
D
HL
T
D
I
T
L
-
K
------
V
A
G
R
I
H
A
K
R
A
S
G
G
K
L
I
F
Y
D
L
R
G
E
G
V
K
L
Q
V
M
A
N
S
R
N
Y
-----
K
S
E
--
E
E
F
I
-
H
I
N
N
K
L
R
R
G
D
I
I
G
V
Q
G
N
P
G
K
T
K
K
G
E
L
S
I
I
P
Y
E
I
T
L
L
S
P
C
L
H
M
L
P
H
L
H
F
G
L
K
D
K
E
T
R
Y
R
Q
R
Y
L
D
L
I
L
N
D
F
V
R
Q
K
F
I
I
R
S
K
I
I
T
Y
I
R
S
F
L
D
E
L
G
F
L
E
I
E
T
P
M
M
--------
N
-
I
I
P
G
G
A
V
A
K
P
F
I
T
Y
H
----
N
E
L
D
M
N
L
Y
M
R
I
A
P
E
L
Y
H
K
M
L
V
V
G
G
I
D
R
V
Y
E
I
G
R
Q
F
R
N
E
G
I
D
L
T
H
N
P
E
F
T
T
C
E
F
Y
M
A
Y
-
A
D
Y
H
D
L
M
E
I
T
E
K
M
V
S
G
M
V
K
H
I
T
G
S
-------
Y
K
V
T
Y
H
P
DGPE
G
Q
A
Y
---
D
V
D
F
T
----------
P
--
P
F
R
R
I
N
M
V
E
E
L
E
K
A
L
-
G
----
M
K
L
P
E
T
-
N
L
F
E
T
E
E
T
R
K
I
L
D
D
I
C
V
A
K
A
V
E
C
-
P
P
---
P
R
T
T
A
R
L
L
D
K
L
V
G
E
F
L
E
V
T
C
--
I
N
P
T
F
I
C
D
H
P
Q
I
M
S
P
-
L
A
K
W
H
R
S
K
E
G
L
T
E
R
F
E
L
F
V
M
K
K
E
I
C
N
A
Y
T
E
L
N
D
P
M
R
Q
R
Q
L
F
E
E
Q
A
K
A
K
A
-
A
G
D
D
E
A
M
F
I
D
E
N
F
C
T
A
L
E
Y
G
L
P
P
T
A
G
W
G
M
G
I
D
R
V
A
M
F
L
T
D
S
N
N
I
K
E
V
L
L
F
P
A
M
K
P
E
----------
84
HHSearch
64.82
32%
-68
* C7 *
3A5Y
1
EPMA_ECOLI
A:
[29-344]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
A
S
I
P
N
L
L
K
R
A
A
I
M
A
E
I
R
R
F
F
A
D
R
G
V
L
E
V
E
T
P
C
M
--------
S
Q
A
T
V
T
D
I
H
L
V
P
F
E
T
R
F
VGPG
H
S
Q
G
M
N
L
W
L
M
T
S
P
E
Y
H
M
K
R
L
L
V
A
G
C
G
P
V
F
Q
L
C
R
S
F
R
N
E
E
M
G
R
Y
H
N
P
E
F
T
M
L
E
W
Y
R
P
H
-
Y
D
M
Y
R
L
M
N
E
V
D
D
L
L
Q
Q
V
L
D
C
P
A
A
E
-------
S
-
L
S
Y
Q
Q
-------
A
F
L
R
Y
L
E
I
D
----------
P
LS
A
-
D
-----------------------------------------------------------
T
L
L
Q
L
L
F
T
F
G
V
E
P
N
I
GK
E
K
P
T
F
V
Y
H
F
P
A
S
Q
A
S
-
L
A
Q
I
S
T
E
D
H
R
V
A
E
R
F
E
V
Y
Y
K
G
I
E
L
A
N
G
F
H
E
L
T
D
A
R
E
Q
Q
Q
R
F
E
Q
D
N
R
K
R
A
A
R
G
L
P
-
Q
H
P
I
D
Q
N
L
I
E
A
L
K
V
G
M
P
D
C
S
G
V
A
L
G
V
D
R
L
V
M
L
A
L
G
A
E
T
L
A
E
V
I
A
F
S
V
D
R
A
-----------
52
PsiBlast_CBE
64.45
32%
-76
- C7 -
3G1Z
5
EPMA_SALTY
B:
[19-325]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
A
A
I
M
A
E
I
R
R
F
F
A
D
R
G
V
L
E
V
E
T
P
C
M
SQATVTDI
H
-
L
F
P
F
E
T
R
---
F
V
G
P
-------
Q
G
I
N
L
Y
L
M
T
S
P
E
Y
H
M
K
R
L
L
A
A
G
C
G
P
V
F
Q
L
C
R
S
F
R
N
E
E
M
G
R
H
H
N
P
E
F
T
M
L
E
W
Y
R
P
H
-
Y
---
D
M
Y
R
L
M
N
E
V
D
D
L
L
Q
Q
V
L
D
C
Q
P
A
E
S
L
S
Y
Q
Q
A
F
Q
R
H
-------
L
---
E
I
D
P
L
----------
S
--
A
-
D
K
T
Q
L
R
E
A
A
A
K
L
D
------
L
----------
E
E
D
R
D
T
-
L
L
Q
L
L
F
T
M
G
--
V
-
E
P
---
H
I
G
K
E
K
------------------
P
T
F
I
Y
H
F
P
A
S
Q
A
S
-
L
A
Q
I
S
T
E
D
H
R
V
A
E
R
F
E
V
Y
Y
K
G
I
E
L
A
N
G
F
H
E
L
T
D
A
R
E
Q
Q
Q
R
F
E
Q
D
N
R
K
----
R
G
L
P
Q
Q
P
I
D
Q
N
L
L
D
A
L
A
A
G
L
P
D
C
S
G
V
A
L
G
V
D
R
L
V
M
L
A
L
G
A
E
S
L
A
D
V
I
A
F
T
V
D
R
A
-----------
19
PsiBlast_PDB
64.27
32%
-75
- C7 -
3G1Z
4
EPMA_SALTY
A:
[19-325]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
A
A
I
M
A
E
I
R
R
F
F
A
D
R
G
V
L
E
V
E
T
P
C
M
SQATVTDI
H
-
L
F
P
F
E
T
R
---
F
V
G
-------
S
Q
G
I
N
L
Y
L
M
T
S
P
E
Y
H
M
K
R
L
L
A
A
G
C
G
P
V
F
Q
L
C
R
S
F
R
N
E
E
M
G
R
H
H
N
P
E
F
T
M
L
E
W
Y
R
P
H
-
Y
---
D
M
Y
R
L
M
N
E
V
D
D
L
L
Q
Q
V
L
D
C
Q
P
A
E
S
L
S
Y
Q
Q
A
F
Q
R
H
-------
L
---
E
I
D
P
L
----------
S
--
A
-
D
K
T
Q
L
R
E
A
A
A
K
L
D
------
L
S
---
N
-
I
A
D
T
E
E
D
R
D
T
-
L
L
Q
L
L
F
T
M
G
--
V
-
E
P
---
H
I
G
K
E
K
------------------
P
T
F
I
Y
H
F
P
A
S
Q
A
S
-
L
A
Q
I
S
T
E
D
H
R
V
A
E
R
F
E
V
Y
Y
K
G
I
E
L
A
N
G
F
H
E
L
T
D
A
R
E
Q
Q
Q
R
F
E
Q
D
N
R
K
R
A
-
A
R
-
L
P
Q
Q
P
I
D
Q
N
L
L
D
A
L
A
A
G
L
P
D
C
S
G
V
A
L
G
V
D
R
L
V
M
L
A
L
G
A
E
S
L
A
D
V
I
A
F
T
V
D
R
A
-----------