@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0216: (2015-12-13 )
MILRASVLSALLLVGLGAAPKHSVSASDKRMQDNLVSVIEKQTNKKVRILEIKPLKSSQDLKMVVIEDPDTKYNIPLVVSKDGNLVIGLSNIFFSNKSDDVKLVAETNQKIQALNATQQNSAKLNAIFNEIPADYAIELPSTNAENKDKILYIVSDPMCPHCQKELTKLRDHLKENTVRMVVVGWLGVNSAKKAALIQEEMAKARARGASVEDKISILEKIYSTQYDINAQKEPEDLRTKVENTTKKIFESGVIKGVPFLYHYKA
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.....-..110.......120.......130.......140.......150.......160.......--170..-.------.------...--.180....-.--.---.190..----.......200.......210.......220..-..-------------------.----------------------.--------------------.--------------230-.-----.---.---..-----...240......-.250.......260...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MI
L
R
A
S
V
L
S
A
L
L
L
VGLGAAPKHSVSA
S
D
K
R
M
Q
D
N
L
V
S
V
I
E
K
QTN
K
K
V
R
I
L
E
I
KPLKSSQ
D
L
K
M
V
V
I
EDPDTKYN
I
P
L
V
V
SKDG
N
L
V
I
G
L
S
N
I
F
FSNKSD
D
V
K
L
V
AET-N
Q
K
I
Q
A
LNATQQNS
A
K
L
N
A
I
F
N
EIPA
D
Y
A
I
ELPSTNAENK
D
K
I
L
Y
I
VSDPMC
P
H
C
Q
K
E
L
T
K
L
--
R
-
D
H
L
-
K
------E------N
T
V
--
R
M
V
V
V
G
W
L-G--V---N
S
--
A
K
----
K
A
A
L
I
Q
E
E
M
A
K
A
RARGA
S
V
E
D
K
I
S
I
L
E
K
I
Y
ST-QY-------------------D----------------------I--------------------N--------------AQ--K-----
E
---
P
---
E
D
-----
L
R
T
K
V
E
N
T
T
K
K
I
-
F
E
SGVIKGV
P
F
L
Y
H
YKA
36
Fugue
93.15
98%
-113
- C1 -
3TDG
2
?
A:
[32-263]
-------------------------------
Q
D
N
L
V
S
V
I
E
K
Q
T
N
K
K
V
R
I
L
E
I
K
P
L
K
S
S
Q
D
L
K
M
V
V
I
E
D
P
D
T
K
Y
N
I
P
L
V
V
S
K
D
G
N
L
I
I
G
L
S
N
I
F
F
S
N
K
S
D
D
V
Q
L
V
A
E
T
-
N
Q
K
V
Q
A
L
N
A
T
Q
Q
N
S
A
K
L
N
A
I
F
N
E
I
P
A
D
Y
A
I
E
L
P
S
T
N
A
A
N
K
D
K
I
L
Y
I
V
S
D
P
M
C
P
H
C
Q
K
E
L
T
K
L
--
R
-
D
H
L
-
K
------
E
------
N
T
V
--
R
M
V
V
V
G
W
L
-
G
--
V
---
N
S
--
A
K
----
K
A
A
L
I
Q
E
E
M
A
K
A
R
A
R
G
A
S
V
E
D
K
I
S
I
L
E
K
I
Y
S
T
-
Q
Y
-------------------
D
----------------------
I
--------------------
N
--------------
A
Q
--
K
-----
E
---
P
---
E
D
-----
L
R
T
K
V
E
N
T
T
K
K
I
-
F
E
S
G
V
I
K
G
V
P
F
L
Y
H
Y
--
1
PsiBlast_PDB
92.99
98%
-113
- C1 -
3TDG
2
?
A:
[32-263]
-------------------------------
Q
D
N
L
V
S
V
I
E
K
Q
T
N
K
K
V
R
I
L
E
I
K
P
L
K
S
S
Q
D
L
K
M
V
V
I
E
D
P
D
T
K
Y
N
I
P
L
V
V
S
K
D
G
N
L
I
I
G
L
S
N
I
F
F
S
N
K
S
D
D
V
Q
L
V
A
E
T
-
N
Q
K
V
Q
A
L
N
A
T
Q
Q
N
S
A
K
L
N
A
I
F
N
E
I
P
A
D
Y
A
I
E
L
P
S
T
N
A
A
N
K
D
K
I
L
Y
I
V
S
D
P
M
C
P
H
C
Q
K
E
L
T
K
L
--
R
-
D
H
L
-
K
------
E
------
N
T
V
--
R
M
V
V
V
G
W
L
-
G
--
V
---
N
S
--
A
K
----
K
A
A
L
I
Q
E
E
M
A
K
A
R
A
R
G
A
S
V
E
D
K
I
S
I
L
E
K
I
Y
S
T
-
Q
Y
-------------------
D
----------------------
I
--------------------
N
--------------
A
Q
--
K
-----
E
---
P
---
E
D
-----
L
R
T
K
V
E
N
T
T
K
K
I
-
F
E
S
G
V
I
K
G
V
P
F
L
Y
H
Y
--
16
HHSearch
50.31
14%
-82
- C1 -
1V58
2
DSBG_ECOLI
A:
[14-207]
---------------------------------------------
G
I
T
I
I
K
T
F
D
A
P
G
--
G
M
K
G
Y
L
G
K
Y
--
Q
D
M
G
V
T
I
Y
L
T
P
D
G
K
H
A
I
-
S
G
Y
M
Y
N
E
K
G
E
N
----
L
S
N
T
L
I
E
K
E
I
Y
A
-------
P
A
G
R
E
M
W
Q
R
M
E
Q
S
H
W
L
L
D
-
G
K
K
--
D
A
P
V
I
V
Y
V
F
A
D
P
F
C
P
Y
C
K
Q
F
W
Q
Q
A
--
R
-
P
W
V
-
D
S
G----
K
------
V
Q
L
--
R
T
L
L
V
G
V
I
-
K
--
P
---
E
S
--
P
A
----
T
A
A
A
I
L
A
----
S
K
D
----
P
A
K
T
W
---
Q
Q
Y
E
A
S
-
G
G
-------------------
K
LK--------------------
L
--------------------
N
--------------
V
P
--
A
-----
N
---
V
S--
T
E
-----
Q
M
K
V
L
S
D
N
E
K
L
M
-
D
D
L
G
A
-
N
V
T
P
A
I
Y
Y
M
S
K
17
HHSearch
48.55
16%
-80
- C1 -
1EEJ
-
DSBC_ECOLI
A:
[4-190]
---------------------------------
A
I
Q
Q
T
L
A
K
-
M
G
I
K
S
S
D
I
Q
P
A
P
V
A
G
---
M
K
T
V
L
T
----
N
S
--
G
V
L
Y
I
T
D
D
G
K
H
I
I
-
Q
G
P
M
Y
D
V
S
G
T
A
P
V
-
N
V
T
N
K
-
M
L
--
L
-------------
K
Q
L
N
A
L
E
-
K
E
M
I
V
Y
-
K
A
P
--
Q
E
K
H
V
I
T
V
F
T
D
I
T
C
G
Y
C
H
K
L
H
E
Q
M
--
A
-
D
Y
N
-
A
L
-----
G
------
I
T
V
--
R
Y
L
A
F
P
R
Q
-
G
LD
S
---
D
A
--
E
K
----
E
M
K
A
I
W
C
----
A
K
D
----
K
N
---
K
A
F
D
D
V
M
A
G
-
K
S
-------------------
V
----------------------------------------------------------
A
P
--
A
-----
S
---
C
---
D
--------
V
D
I
A
D
H
Y
A
L
G
-
V
Q
L
G
V
-
S
G
T
P
A
V
V
L
S
N
G
18
HHSearch
47.44
19%
-84
- C1 -
1T3B
-
DSBC_HAEIN
A:
[3-190]
--------------------------------
A
A
I
K
R
K
L
Q
-
S
F
N
I
S
N
I
V
I
K
S
S
P
I
S
G
---
I
K
T
A
V
T
----
D
Q
--
G
I
L
Y
V
S
E
D
G
K
Y
L
F
-
E
G
K
L
Y
E
L
T
N
N
G
P
V
-
D
V
A
G
----
K
I
L
V
------------
D
K
L
-
N
S
Y
K
D
E
M
I
V
Y
-
P
A
K
--
N
E
K
H
V
V
T
V
F
M
D
I
T
C
H
Y
C
H
L
L
H
Q
Q
L
--
K
-
E
Y
N
D
L
------
G
------
I
T
V
--
R
Y
L
A
F
P
R
A
-
G
--
M
NN-
Q
T
--
A
K
----
Q
M
E
A
I
W
T
----
A
K
D
-------
P
V
F
A
L
N
E
A
E
K
G
-
N
L
-------------------
P
----------------------------------------------------------
K
E
----------------
V
K
-----
T
P
N
I
V
K
K
H
Y
E
L
G
-
I
Q
F
G
V
-
R
G
T
P
S
I
V
T
S
T
G
8
PsiBlast_PDB
46.87
31%
-91
- C1 -
3EMX
-
?
A:
[255-314]
----------------------------------------------------------------------------------------------------------------------------------------------------
D
A
I
L
A
V
Y
S
K
-
T
C
P
H
C
H
R
D
W
P
Q
L
--
I
-
Q
A
S
-
K
------
E
------
V
D
V
--
P
I
V
M
F
I
W
G
-
S
--
L
---
I
G
--
E
R
----
E
L
S
A
A
R
L
E
M
N
K
A
G
V
E
G
--------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
46.64
13%
-63
- C1 -
3GYK
4
?
A:
[11-151]
-------------------------------------------------------------------------------------------------------------------------------------
D
P
N
A
P
V
L
-
G
N
P
--
E
G
D
V
T
V
V
E
F
F
D
Y
N
C
P
Y
C
R
R
A
M
A
E
V
--
Q
-
G
L
V
-
D
A
D
P---
N
------
V
R
L
--
V
Y
R
E
W
P
I
L
-
G
--
E
---
G
S
--
D
F
----
A
A
R
A
A
L
A
----
A
R
Q
----
Q
G
K
Y
E
A
F
H
W
A
L
M
G
M
-
S
G
-------------------
K
----------------------
A
N
E
T
G
V
L
R
I
A
R
E
V
GL------
D
--------------
T
E
Q
L
Q
-----
R
D
M
E
A
---
P
E
-----
V
T
A
H
I
A
Q
S
M
A
L
A
-
Q
K
L
G
F
-
N
G
T
P
S
F
V
V
E
D
A
20
HHSearch
45.61
22%
-57
- C1 -
3GN3
2
?
A:
[10-161]
---------------------------------------------------------------------------------------------------------------------------------------------
S
W
G
--
H
G
P
R
L
F
E
V
F
L
E
P
T
C
P
F
S
V
K
A
F
F
K
L
--
D
-
D
L
L
-
A
Q
A
GED-
N
------
V
T
V
--
R
I
R
L
Q
S
Q
P
W
H
--
M
---
F
S
--
G
V
----
I
V
R
C
I
L
A
----
A
A
T
L
E
G
G
K
E
S
A
K
A
V
M
T
A
V
A
S
H
-
R
E
-------------------
E
----------------------
F
EFEHHAGGPNLDA-------
T
P
N
D
I
I
A
R
I
E
R
Y
S
GL
A
L
--
A
-----
E
---
A
F
A
N
P
E
-----
L
E
H
A
V
K
W
H
T
K
Y
A
-
R
Q
N
G
I
-
H
V
S
P
T
F
M
I
N
G
L
23
HHSearch
45.44
12%
-74
- C1 -
3F4S
1
?
A:
[28-179]
-------------------------------------------------------------------------------------------------------------------------------------
L
P
N
D
K
L
L
-
G
D
P
--
K
A
P
I
L
M
I
E
Y
A
S
L
T
C
Y
H
C
S
L
F
H
R
N
V
--
F
-
P
K
I
K
E
K
YIDTG
K
------
M
L
Y
--
I
F
R
H
F
P
L
D
-
Y
------
R
G
--
L
K
----
A
A
M
L
S
H
C
----
Y
E
K
----
Q
E
D
Y
F
N
F
N
K
A
V
F
N
S
-
I
D
-------------------
S
WNYYN-----------------
L
SDL
T
L
L
Q
R
I
A
A
L
S
NL-----
K
--------------
Q
D
A
F
N
-----
Q
---
C
I
N
D
K
K
-----
I
M
D
K
I
V
N
D
K
S
L
A
I
N
K
L
G
I
-
T
A
V
P
I
F
F
I
K
L
N
29
HHSearch
44.71
12%
-66
- C1 -
3H93
3
DSBA_PSEAE
A:
[16-159]
---------------------------------------------------------------------------------------------------------------------------------------
S
S
P
V
P
-
V
S
Q
--
P
G
K
I
E
V
V
E
L
F
W
Y
G
C
P
H
C
Y
A
F
E
P
T
I
--
V
-
P
W
S
-
E
------
K
LP----
A
D
V
--
H
F
V
R
L
P
A
L
-
F
--
G
G
--
I
W
--
N
V
----
H
G
Q
M
F
L
T
----
L
E
S
----
M
G
V
E
H
D
V
H
N
A
V
F
E
A
-
I
H
-------------------
K
EHKKLAT
P
E
E
M
A
D
F
L
A
G
K
G---
V
--------------------
D
--------------
K
E
--
K
F
L
---
S
T
Y
N
S
---
F
A
-----
I
K
G
Q
M
E
K
A
K
K
L
A
-
M
A
Y
Q
V
-
T
G
V
P
T
M
V
V
N
G
K
19
HHSearch
43.73
14%
-64
- C1 -
1Z6M
-
?
A:
[15-157]
------------------------------------------------------------------------------------------------------------------------------------
N
T
E
T
G
L
H
I
-
G
E
S
--
N
A
P
V
K
M
I
E
F
I
N
V
R
C
P
Y
C
R
K
W
F
E
E
S
--
E
-
E
L
L
-
A
------
Q
S
V
K
S
GK
V
E
R
--
I
I
K
L
F
D
K
E
-
K
--
E
---
S
L
--
Q
R
G
N
V
M
H
H
Y
I
D
Y
S
----
A
------
P
E
Q
A
L
S
A
L
H
K
M
F
A
T
-
Q
D
-------------------
E
----------------------
W
GNLT
L
E
E
V
------------
A
T
-------------
Y
A
--
E
KNLG
L
K
---
E
---
Q
K
-----
D
A
T
L
V
S
A
V
I
A
E
A
-
N
A
A
H
I
-
Q
F
V
P
T
I
I
I
G
E
Y
21
HHSearch
43.19
16%
-52
- C1 -
3BCI
-
?
A:
[14-159]
---------------------------------------------------------------------------------------------------------------------------------------------------
G
K
P
L
V
V
V
Y
G
D
Y
K
C
P
Y
C
K
E
L
D
E
K
V
M
-
P
-
K
L
R
-
K
N
YIDNH
K
------
V
E
Y
--
Q
F
V
N
L
A
F
L
-
G
--
K
---
D
S
--
I
V
----
G
S
R
A
S
H
A
V
L
--
M
Y
A
----
P
K
S
F
L
D
F
Q
K
Q
L
F
A
A
-
Q
Q
-------------------
D
ENKEWLT
K
E
L
------------
L
D
K
H
I
K
Q
L
HL-----------
D
--------------
K
E
T
E
N
-----
K
---
I
I
K
D
Y
K
TKDS
K
S
W
K
A
A
E
K
D
K
K
I
A
-
K
D
N
H
I
-
K
T
T
P
T
A
F
I
N
G
E
22
HHSearch
42.26
19%
-64
- C1 -
3GHA
2
BDBD_BACSU
A:
[19-170]
--------------------------------------------------------------------------------------------------------------------------------------
K
G
Q
P
V
L
-
G
K
D
--
D
A
P
V
T
V
V
E
F
G
D
Y
K
C
P
S
C
K
V
F
N
S
D
I
--
F
P
K
I
Q
-
K
D
FIDKG
D
------
V
K
F
--
S
F
V
N
V
M
F
H
-
G
--
K
---
G
S
--
R
L
----
A
A
L
A
S
E
E
V
W
--
K
E
D
----
P
D
S
F
W
D
F
H
E
K
L
F
E
K
-
Q
P
-------------------
D
----------------------
T
EQEWVT
P
G
L
L
G
D
L
A
K
S
TTKI
K
--------------
P
E
T
L
K
-----
E
---
N
L
D
K
E
T
-----
F
A
S
Q
V
E
K
D
S
D
L
N
-
Q
K
M
N
I
-
Q
A
T
P
T
I
Y
V
N
D
K
25
HHSearch
41.54
20%
-63
- C1 -
3GV1
2
?
A:
[5-118]
---------------------------------------------------------------------------------------------------------------------------------------
K
A
I
K
E
-
V
R
G
--
N
G
K
L
K
V
A
V
F
S
D
P
D
C
P
F
C
K
R
L
E
H
E
F
--
E
-
K
M
--
T
------
D
------
V
T
V
--
Y
S
F
M
M
P
I
A
-
G
LH
P
---
D
A
--
A
R
----
K
A
Q
I
L
W
C
----
Q
P
D
----
R
---
A
K
A
W
T
D
W
M
R
K
-
G
K
-------------------
F
-------------------------------------------
P
--------------
V
G
------------
G
---
S
I
-----
C
D
N
P
V
A
E
T
T
S
L
G
-
E
Q
F
G
F
-
N
G
T
P
T
L
V
F
P
N
G
32
HHSearch
41.38
16%
-56
- C1 -
3FEU
1
?
A:
[22-159]
---------------------------------------------------------------------------------------------------------------------------------------------------
G
M
A
P
V
T
E
V
F
A
L
S
C
G
H
C
R
N
M
E
N
F
L
--
P
-
V
I
S
-
Q
------
E
A
G
T
D
I
-
G
K
M
--
H
I
T
F
N
Q
S
A
------------
H
I
----
A
S
M
F
Y
Y
A
-
A
E
M
Q
V
D
----
G
A
P
D
H
A
F
M
E
D
L
F
A
A
T
Q
M
GEGT---------------
T
----------------------
L
T
E
Q
Q
E
A
Y
S
K
A
F
T
S
R
GLV---
S
--------------
P
Y
DF
N
-----
E
---
E
Q
R
-
D
T
-----
L
I
K
K
V
D
N
A
K
M
L
S
-
E
K
S
G
I
-
S
S
V
P
T
F
V
V
N
G
K
34
HHSearch
40.71
26%
-79
- C1 -
2IN3
4
?
A:
[6-51]
---------------------------------------------------------------------------------------------------------------------------------------------------
E
K
P
V
L
W
Y
I
A
D
P
M
C
S
W
C
W
G
F
A
P
V
I
--
E
-
N
I
R
-
Q
------
E
YSAF--
L
T
V
--
K
I
M
P
G
G
T
N
-
T
--
P
---
L
L
--
P
E
----
K
R
A
Q
I
L
H
H
W
H
S
V
H
I
T
T
G
Q
P
F
T
F
E
N
A
L
P
E
G
F
I
Y
-
D
T
-------------------
E
----------------------
P
--------------------
A
--------------
C
R
--
G
-----
V
---
V
---
S
V
-----
S
L
I
E
P
E
K
V
F
P
F
F
-
A
A
I
Q
R
A
F
Y
V
G
Q
E
D
V
A
Q
L
27
HHSearch
40.48
10%
-50
* C1 *
2REM
-
?
A:
[16-162]
---------------------------------------------------------------------------------------------------------------------------------------
D
G
R
P
F
-
A
P
L
--
A
G
K
I
E
V
V
E
I
F
G
Y
T
C
P
H
C
A
H
F
D
S
K
L
--
Q
-
A
W
G
-
A
R
QAK--
D
------
V
R
F
--
T
L
V
P
A
V
F
G
-
G
------
V
W
--
D
P
----
F
A
R
A
Y
L
A
----
A
D
V
----
L
G
V
A
K
R
S
H
T
A
M
F
E
A
-
I
H
-------------------
E
KGSVPIQNVG
P
D
E
L
A
V
F
Y
A
G
Y
G
V
--------------------
Q
--------------
P
D
R
F
V
-----
A
---
T
F
N
G
P
E
-----
V
E
K
R
F
Q
A
A
R
A
Y
A
-
L
K
V
R
P
-
V
G
T
P
T
I
V
V
N
G
R
5
PsiBlast_PDB
39.89
32%
-85
- C1 -
2H0I
1
DSBG_ECOLI
A:
[100-149]
------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
Y
V
F
A
D
P
F
C
P
Y
C
K
Q
F
W
Q
Q
A
--
R
-
P
W
V
-
D
------
S
------
G
K
V
Q
L
R
T
L
L
V
G
V
I
-
K
--
P
---
E
S
--
P
A
----
T
A
A
A
I
L
A
S
K
D
P
A
K
T
W
Q
Q
Y
E
A
S
G
G
K
L
K
L
N
V
P
A
N
-
V
S
-------------------
T
----------------------
E
--------------------
Q
--------------
M
K
--
V
-----
L
---
S
---
D
N
-----
E
K
L
M
D
D
L
G
A
N
V
T
-
P
A
I
Y
Y
M
S
K
E
N
T
L
Q
Q
A
M
G
30
HHSearch
39.68
15%
-48
- C1 -
3L9V
1
?
A:
[16-153]
-----------------------------------------------------------------------------------------------------------------------------------------------------
P
A
V
V
E
F
F
S
F
Y
C
P
P
C
Y
A
F
S
Q
T
M
G
V
D
-
Q
A
I
-
R
H
V
LPQ-
G
------
S
R
M
--
V
K
Y
H
V
S
L
L
-
G
--
P
---
L
G
H
E
L
T
----
R
A
W
A
L
A
M
----
V
M
K
------
E
T
D
V
I
E
K
A
F
F
T
A
-
G
M
VEKRLHS
P
D
D
V
R
R
V
F
M
S
A
T
G
----------------------
I
--------------------
S
--------------
R
G
E
Y
D
-----
R
S
I
K
S
---
P
A
-----
V
N
D
M
V
A
L
Q
E
R
L
F
-
K
E
Y
G
V
-
R
G
T
P
S
V
Y
V
R
G
R
31
HHSearch
39.32
15%
-45
- C1 -
3HZ8
-
?
A:
[44-183]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
G
K
V
E
V
L
E
F
F
G
Y
F
C
P
H
C
A
H
L
E
P
V
L
--
S
-
K
H
A
-
K
S
FKD--
D
------
M
Y
L
--
R
T
E
H
V
V
W
Q
-
K
--
E
M
L
T
L
A
--
R
L
----
A
A
A
V
D
M
A
----
A
A
D
S
K
--
D
V
A
N
S
H
I
F
D
A
M
V
N
Q
-
K
I
-------------------
K
----------------------
L
QN
P
E
V
L
K
K
W
L
G
E
QTAF----
D
--------------
G
K
K
V
L
-----
A
---
A
Y
E
S
P
E
-----
S
Q
A
R
A
D
K
M
Q
E
L
T
-
E
T
F
Q
I
-
D
G
V
P
T
V
I
V
G
G
K