@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0275: (2015-12-14 )
MFNYEELFQTYKTPFYLYDFDKIKQAFLNYKEAFKGRKSLICYALKANSNLSILSLLANLGSGADCVSIGEIQRALKAGIKPYKIVFSGVGKSAFEIEQALKLNILFLNVESFMELKTIETIAQSLGIKARISIRINPNIDAKTHPYISTGLKENKFGVEEKEALEMFLWAKKSAFLEPVSVHFHIGSQLLDLDPITEASQKVAKIAKSLIALGIDLRFFDVGGGIGVSYENEETIKLYDYAQGILNSLQGLDLTIICEPGRSIVAESGELITQVLYEKKAQNKRFVIVDAGMNDFLRPSLYHAKHAIRVITPCGGREISPCDVVGPVCESSDTFLKDANLPELEPGDKLAIEKVGAYGSSMASQYNSRPKLLELALEDHKIRVIRKREALEDLWRLEIEGLEGV
Atome Classification :
(24 SA)
......-------------...10........20........30....------.------...40........50........60........70........80----...----.....--90........100.......110.......120.......130.......140.......150......--.160...--....170.......180.......190.......200.......210.......220.......230.-....---.-.-240.........----250-----....-.....260.......270.......280.......290.......300.......-310.....----....320...-----....330......-------.340-----.........350.......360.......370..-.....-380.......390.......400...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MF
N
Y
E
E
-------------
L
F
Q
T
YKT
P
F
Y
L
Y
D
F
D
K
I
K
Q
A
F
L
N
Y
K
E
A
FK------G------R
K
S
L
I
C
Y
A
L
KANSN
L
S
I
L
S
L
L
A
NLGSGAD
C
V
S
I
G
E
I
Q
R
A
L
K
AGI
K
----
P
Y
K
----
I
V
F
SG--VG
K
S
A
F
E
I
E
Q
A
L
K
L
N
I
L
F
L
N
V
E
S
F
M
E
L
K
T
I
E
T
I
A
Q
SLG
I
K
A
R
I
S
I
R
INPNIDAKTHPYISTGLKENKFG--V
E
E
K
E
A
L
--
E
M
F
L
W
AKKSAFLE
P
V
S
V
H
F
HIG
S
Q
LLDLDPI
T
E
A
S
Q
K
V
A
K
I
A
K
S
L
I
A
LG
I
D
L
R
F
F
DVGGG
I
G
V
S
YENE-
E
T
I
K
---
L
-
Y
-
D
--
Y
A
Q
G
I
L
N
SL----Q-------GL
D
L
-
T
I
I
CEP
G
R
S
I
V
AE
S
G
E
L
I
T
Q
V
L
Y
E
KKAQNK
R
F
V
I
V
DAG
M
N
DFL
R
P
S
L
Y
H
A
K
H
A
I
R
-
V
--
I
TPCG----GREISPCDVV-----GPVCESSDTFLKD-------AN-------LPELEPGD
K
L
A
I
E
K
VGAY
G
S
S
M
A
S
Q
YNSR
P
K
L
L
E
-
L
A
LED-H
K
I
R
V
I
R
K
R
E
A
L
E
D
L
W
R
L
EIEGLEGV
30
HHSearch
97.11
97%
-110
- C2 -
2QGH
2
DCDA_HELPX
A:
[23-422]
--
N
Y
E
E
-------------
L
F
Q
T
H
K
T
P
F
Y
L
Y
D
F
D
K
I
K
Q
A
F
L
N
Y
K
E
A
F
K
------
G
------
R
K
S
L
I
C
Y
A
L
K
A
N
S
N
L
S
I
L
S
L
L
A
H
L
E
S
G
A
D
C
V
S
I
G
E
I
Q
R
A
L
K
A
G
I
K
----
P
Y
R
----
I
V
F
S
G
--
V
G
K
S
A
F
E
I
E
Q
A
L
K
L
N
I
L
F
L
N
V
E
S
F
M
E
L
K
T
I
E
T
I
A
Q
S
L
G
I
K
A
R
I
S
I
R
I
N
P
N
I
D
A
K
T
H
P
Y
I
S
T
G
L
K
E
N
K
F
G
--
V
G
E
K
E
A
L
--
E
M
F
L
W
A
K
K
S
A
F
L
E
P
V
S
V
H
F
H
I
G
S
Q
L
L
D
L
E
P
I
I
E
A
S
Q
K
V
A
K
I
A
K
S
L
I
A
L
G
I
D
L
R
F
F
D
V
G
G
G
I
G
V
S
Y
E
N
E
-
E
T
I
K
---
L
-
Y
-
D
--
Y
A
Q
G
I
L
N
A
L
----
Q
-------
G
L
D
L
-
T
I
I
C
E
P
G
R
S
I
V
A
E
S
G
E
L
I
T
Q
V
L
Y
E
K
K
--
N
K
R
F
V
I
V
D
A
G
M
N
D
F
L
R
P
S
L
Y
H
A
K
H
A
I
R
-
V
--
I
T
P
S
-------
E
I
S
P
C
D
V
V
-----
G
P
V
C
E
S
S
D
T
F
L
K
D
-------
A
H
-------
L
P
E
L
E
P
G
D
K
I
A
I
E
K
V
G
A
Y
G
S
S
M
A
S
Q
Y
N
S
R
P
K
L
L
E
-
L
A
L
E
D
--
K
I
R
V
I
R
K
R
E
A
L
E
D
L
W
R
L
E
E
E
G
L
---
1
PsiBlast_PDB
96.88
96%
-110
- C2 -
2QGH
2
DCDA_HELPX
A:
[23-422]
--
N
Y
E
E
-------------
L
F
Q
T
H
K
T
P
F
Y
L
Y
D
F
D
K
I
K
Q
A
F
L
N
Y
K
E
A
F
K
------
G
------
R
K
S
L
I
C
Y
A
L
K
A
N
S
N
L
S
I
L
S
L
L
A
H
L
E
S
G
A
D
C
V
S
I
G
E
I
Q
R
A
L
K
A
G
I
K
----
P
Y
R
----
I
V
F
S
G
--
V
G
K
S
A
F
E
I
E
Q
A
L
K
L
N
I
L
F
L
N
V
E
S
F
M
E
L
K
T
I
E
T
I
A
Q
S
L
G
I
K
A
R
I
S
I
R
I
N
P
N
I
D
A
K
T
H
P
Y
I
S
T
G
L
K
E
N
K
F
G
--
V
G
E
K
E
A
L
--
E
M
F
L
W
A
K
K
S
A
F
L
E
P
V
S
V
H
F
H
I
G
S
Q
L
L
D
L
E
P
I
I
E
A
S
Q
K
V
A
K
I
A
K
S
L
I
A
L
G
I
D
L
R
F
F
D
V
G
G
G
I
G
V
S
Y
E
N
E
-
E
T
I
K
---
L
-
Y
-
D
--
Y
A
Q
G
I
L
N
A
L
----
Q
-------
G
L
D
L
-
T
I
I
C
E
P
G
R
S
I
V
A
E
S
G
E
L
I
T
Q
V
L
Y
E
K
K
--
N
K
R
F
V
I
V
D
A
G
M
N
D
F
L
R
P
S
L
Y
H
A
K
H
A
I
R
-
V
--
I
T
P
S
-------
E
I
S
P
C
D
V
V
-----
G
P
V
C
E
S
S
D
T
F
L
K
D
-------
A
H
-------
L
P
E
L
E
P
G
D
K
I
A
I
E
K
V
G
A
Y
G
S
S
M
A
S
Q
Y
N
S
R
P
K
L
L
E
-
L
A
L
E
D
--
K
I
R
V
I
R
K
R
E
A
L
E
D
L
W
R
L
E
E
E
G
L
---
2
PsiBlast_PDB
96.35
96%
-108
- C2 -
3C5Q
3
DCDA_HELPX
A:
[23-422]
--
N
Y
E
E
-------------
L
F
Q
T
H
K
T
P
F
Y
L
Y
D
F
D
K
I
K
Q
A
F
L
N
Y
K
E
A
F
K
------
G
------
R
K
S
L
I
C
Y
A
L
K
A
N
S
N
L
S
I
L
S
L
L
A
H
L
E
S
G
A
D
C
V
S
I
G
E
I
Q
R
A
L
K
A
G
I
K
----
P
Y
R
----
I
V
F
S
G
--
V
G
K
S
A
F
E
I
E
Q
A
L
K
L
N
I
L
F
L
N
V
E
S
F
M
E
L
K
T
I
E
T
I
A
Q
S
L
G
I
K
A
R
I
S
I
R
I
N
P
N
I
D
A
K
T
H
P
Y
L
S
T
G
L
K
E
N
K
F
G
--
V
G
E
K
E
A
L
--
E
M
F
L
W
A
K
K
S
A
F
L
E
P
V
S
V
H
F
H
I
G
S
Q
L
L
D
L
E
P
I
I
E
A
S
Q
K
V
A
K
I
A
K
S
L
I
A
L
G
I
D
L
R
F
F
D
V
G
G
G
I
G
V
S
Y
E
N
E
-
E
T
I
K
---
L
-
Y
-
D
--
Y
A
Q
G
I
L
N
A
L
----
Q
-------
G
L
D
L
-
T
I
I
C
E
P
G
R
S
I
V
A
E
S
G
E
L
I
T
Q
V
L
Y
E
K
K
--
N
K
R
F
V
I
V
D
A
G
M
N
D
F
L
R
P
S
L
Y
H
A
K
H
A
I
R
-
V
--
I
T
P
S
-------
E
I
S
P
C
D
V
V
-----
G
P
V
C
E
S
S
D
T
F
L
K
D
-------
A
H
-------
L
P
E
L
E
P
G
D
K
I
A
I
E
K
V
G
A
Y
G
S
S
M
A
S
Q
Y
N
S
R
P
K
L
L
E
-
L
A
L
E
D
--
K
I
R
V
I
R
K
R
E
A
L
E
D
L
W
R
L
E
E
E
G
L
---
35
HHSearch
78.95
45%
-104
- C2 -
2P3E
-
DCDA_AQUAE
A:
[24-416]
--
S
L
K
E
-------------
L
A
Q
T
F
G
T
P
L
Y
V
Y
S
S
N
F
I
K
E
R
F
E
A
Y
R
K
A
F
P
--------------
D
A
L
I
C
Y
A
V
K
A
N
F
N
P
H
L
V
K
L
L
G
E
L
G
A
G
A
D
I
V
S
G
G
E
L
Y
L
A
K
K
A
G
I
P
----
P
E
R
----
I
V
Y
A
G
--
V
G
K
T
E
K
E
L
T
D
A
V
D
S
E
I
L
M
F
N
V
E
S
R
Q
E
L
D
V
L
N
E
I
A
G
K
L
G
K
K
A
R
I
A
I
R
V
N
P
----------------
S
K
F
G
--
V
D
I
R
E
A
Q
--
K
E
Y
E
Y
A
S
K
L
E
N
L
E
I
V
G
I
H
C
H
I
G
S
Q
I
L
D
I
S
P
Y
R
E
A
V
E
K
V
V
S
L
Y
E
S
L
T
Q
K
G
F
D
I
K
Y
L
D
I
G
G
G
L
G
I
K
Y
K
P
E
D
K
E
P
A
---
P
-
Q
-
D
--
L
A
D
L
L
K
D
L
L
-------------
V
K
A
-
K
I
I
L
E
P
G
R
S
I
M
G
N
A
G
I
L
I
T
Q
V
Q
F
L
K
D
K
G
S
K
H
F
I
I
V
D
A
G
M
N
D
L
I
R
P
S
I
Y
N
A
Y
H
H
I
I
-
P
--
V
E
T
K
-----
E
---
V
V
A
D
I
V
-----
G
P
I
C
E
T
G
D
F
L
A
L
D
-------
R
E
-------
I
E
E
V
Q
R
G
E
Y
L
A
V
L
S
A
G
A
Y
G
F
A
M
S
S
H
Y
N
M
R
P
R
A
A
E
-
V
L
V
E
N
-
G
S
V
K
L
I
R
K
R
E
N
Y
D
Y
I
V
E
P
S
L
D
I
----
4
PsiBlast_PDB
78.48
45%
-102
- C2 -
2P3E
-
DCDA_AQUAE
A:
[26-408]
----
K
E
-------------
L
A
Q
T
F
G
T
P
L
Y
V
Y
S
S
N
F
I
K
E
R
F
E
A
Y
R
K
A
F
P
--------------
D
A
L
I
C
Y
A
V
K
A
N
F
N
P
H
L
V
K
L
L
G
E
L
G
A
G
A
D
I
V
S
G
G
E
L
Y
L
A
K
K
A
G
I
P
----
P
E
R
----
I
V
Y
A
G
--
V
G
K
T
E
K
E
L
T
D
A
V
D
S
E
I
L
M
F
N
V
E
S
R
Q
E
L
D
V
L
N
E
I
A
G
K
L
G
K
K
A
R
I
A
I
R
V
N
P
----------------
S
K
F
G
--
V
D
I
R
E
A
Q
--
K
E
Y
E
Y
A
S
K
L
E
N
L
E
I
V
G
I
H
C
H
I
G
S
Q
I
L
D
I
S
P
Y
R
E
A
V
E
K
V
V
S
L
Y
E
S
L
T
Q
K
G
F
D
I
K
Y
L
D
I
G
G
G
L
G
I
K
Y
K
P
E
-
D
K
E
P
---
A
P
Q
-
D
--
L
A
D
L
L
K
D
L
L
-------------
V
K
A
-
K
I
I
L
E
P
G
R
S
I
M
G
N
A
G
I
L
I
T
Q
V
Q
F
L
K
D
K
G
S
K
H
F
I
I
V
D
A
G
M
N
D
L
I
R
P
S
I
Y
N
A
Y
H
H
I
--
I
--
P
V
E
T
K
----
E
---
V
V
A
D
I
V
-----
G
P
I
C
E
T
G
D
F
L
A
L
D
-------
R
E
-------
I
E
E
V
Q
R
G
E
Y
L
A
V
L
S
A
G
A
Y
G
F
A
M
S
S
H
Y
N
M
R
P
R
A
A
E
-
V
L
V
E
N
-
G
S
V
K
L
I
R
K
R
E
N
Y
D
Y
I
V
E
P
S
L
D
I
----
21
PsiBlast_CBE
77.98
44%
-105
- C2 -
3N2B
1
DCDA_VIBCH
D:
[28-436]
-
F
N
Y
Q
E
DGQLWAEQVP
L
A
D
L
A
N
Q
Y
G
T
P
L
Y
V
Y
S
R
A
T
L
E
R
H
W
H
A
F
D
K
S
V
G
------
D
------
Y
P
H
L
I
C
Y
A
V
K
A
N
S
N
L
G
V
L
N
T
L
A
R
L
G
S
G
F
D
I
V
S
V
G
E
L
E
R
V
L
A
A
G
G
D
----
P
S
K
----
V
V
F
S
G
--
V
G
K
T
E
A
E
M
K
R
A
L
Q
L
K
I
K
C
F
N
V
E
S
E
P
E
L
Q
R
L
N
K
V
A
G
E
L
G
V
K
A
P
I
S
L
R
I
N
P
D
V
D
A
K
T
H
P
Y
I
S
T
G
L
R
D
N
K
F
G
--
I
T
F
D
R
A
A
--
Q
V
Y
R
L
A
H
S
L
P
N
L
D
V
H
G
I
D
C
H
I
G
S
Q
L
T
A
L
A
P
F
I
D
A
T
D
R
L
L
A
L
I
D
S
L
K
A
E
G
I
H
I
R
H
L
D
V
G
G
G
L
-----------------
S
-
E
--
Y
A
K
A
L
L
D
R
L
----
E
R------
H
R
D
L
-
E
L
I
F
E
P
G
R
A
I
A
A
N
A
G
V
L
V
T
K
V
E
F
L
K
H
T
E
H
K
N
F
A
I
I
D
A
A
M
N
D
L
I
-------
W
Q
D
I
I
-
P
--
L
R
P
R
Q
----
G
-
E
A
Q
T
Y
D
L
V
-----
G
P
V
C
E
T
S
D
F
L
G
K
D
-------
R
D
-------
L
-
V
L
Q
E
G
D
L
L
A
V
R
S
S
G
A
Y
G
F
T
M
S
S
N
Y
N
T
R
P
R
V
A
E
-
V
M
V
D
G
-
N
K
T
Y
L
V
R
Q
R
E
E
L
S
S
L
W
A
L
E
S
V
L
P
E
--
22
PsiBlast_CBE
76.92
44%
-101
- C2 -
3N2B
2
DCDA_VIBCH
C:
[28-436]
-
F
N
Y
Q
E
DGQLWAEQVP
L
A
D
L
A
N
Q
Y
G
T
P
L
Y
V
Y
S
R
A
T
L
E
R
H
W
H
A
F
D
K
S
V
G
------
D
------
Y
P
H
L
I
C
Y
A
V
K
A
N
S
N
L
G
V
L
N
T
L
A
R
L
G
S
G
F
D
I
V
S
V
G
E
L
E
R
V
L
A
A
G
G
D
----
P
S
K
----
V
V
F
S
G
--
V
G
K
T
E
A
E
M
K
R
A
L
Q
L
K
I
K
C
F
N
V
E
S
E
P
E
L
Q
R
L
N
K
V
A
G
E
L
G
V
K
A
P
I
S
L
R
I
N
P
D
V
D
A
K
T
H
P
Y
I
S
T
G
L
R
D
N
K
F
G
--
I
T
F
D
R
A
A
--
Q
V
Y
R
L
A
H
S
L
P
N
L
D
V
H
G
I
D
C
H
I
G
S
Q
L
T
A
L
A
P
F
I
D
A
T
D
R
L
L
A
L
I
D
S
L
K
A
E
G
I
H
I
R
H
L
D
V
G
G
G
L
G
V
V
--------
Q
---
P
-
S
-
E
--
Y
A
K
A
L
L
D
R
L
----
E
R------
H
R
D
L
-
E
L
I
F
E
P
G
R
A
I
A
A
N
A
G
V
L
V
T
K
V
E
F
L
K
H
T
E
H
K
N
F
A
I
I
D
A
A
M
N
D
L
I
R
------
W
Q
D
I
I
-
P
--
L
R
P
R
Q
----
G
-
E
A
Q
T
Y
D
L
V
-----
G
P
V
C
E
T
S
D
F
L
G
K
D
-------
R
D
-------
L
-
V
L
Q
E
G
D
L
L
A
V
R
S
S
G
A
Y
G
F
T
M
S
S
N
Y
N
T
R
P
R
V
A
E
-
V
M
V
D
G
-
N
K
T
Y
L
V
R
Q
R
E
E
L
S
S
L
W
A
L
E
S
V
L
P
E
--
3
PsiBlast_PDB
76.26
44%
-106
- C2 -
3N2B
1
DCDA_VIBCH
A:
[28-436]
-
F
N
Y
Q
E
DGQLWAEQVP
L
A
D
L
A
N
Q
Y
G
T
P
L
Y
V
Y
S
R
A
T
L
E
R
H
W
H
A
F
D
K
S
V
G
------
D
------
Y
P
H
L
I
C
Y
A
V
K
A
N
S
N
L
G
V
L
N
T
L
A
R
L
G
S
G
F
D
I
V
S
V
G
E
L
E
R
V
L
A
A
G
G
D
----
P
S
K
----
V
V
F
S
G
--
V
G
K
T
E
A
E
M
K
R
A
L
Q
L
K
I
K
C
F
N
V
E
S
E
P
E
L
Q
R
L
N
K
V
A
G
E
L
G
V
K
A
P
I
S
L
R
I
N
P
D
V
D
A
K
T
H
P
Y
I
S
T
G
L
R
D
N
K
F
G
--
I
T
F
D
R
A
A
--
Q
V
Y
R
L
A
H
S
L
P
N
L
D
V
H
G
I
D
C
H
I
G
S
Q
L
T
A
L
A
P
F
I
D
A
T
D
R
L
L
A
L
I
D
S
L
K
A
E
G
I
H
I
R
H
L
D
V
G
G
G
L
G
V
V
Y
------
P
Q
---
P
-
S
-
E
--
Y
A
K
A
L
L
D
R
L
----
E
R
------
H
R
D
L
-
E
L
I
F
E
P
G
R
A
I
A
A
N
A
G
V
L
V
T
K
V
E
F
L
K
H
T
--
K
N
F
A
I
I
D
A
A
M
N
D
L
I
R
-------
Q
D
I
I
-
P
--
L
R
P
R
Q
----
G
-
E
A
Q
T
Y
D
L
V
-----
G
P
V
C
E
T
S
D
F
L
G
K
D
-------
R
D
-------
L
-
V
L
Q
E
G
D
L
L
A
V
R
S
S
G
A
Y
G
F
T
M
S
S
N
Y
N
T
R
P
R
V
A
E
-
V
M
V
D
G
-
N
K
T
Y
L
V
R
Q
R
E
E
L
S
S
L
W
A
L
E
S
V
L
P
E
--
36
HHSearch
76.14
45%
-105
- C2 -
3N2B
1
DCDA_VIBCH
A:
[42-439]
--
P
L
A
D
-------------
L
A
N
Q
Y
G
T
P
L
Y
V
Y
S
R
A
T
L
E
R
H
W
H
A
F
D
K
S
V
G
------
D
------
Y
P
H
L
I
C
Y
A
V
K
A
N
S
N
L
G
V
L
N
T
L
A
R
L
G
S
G
F
D
I
V
S
V
G
E
L
E
R
V
L
A
A
G
G
D
----
P
S
K
----
V
V
F
S
G
--
V
G
K
T
E
A
E
M
K
R
A
L
Q
L
K
I
K
C
F
N
V
E
S
E
P
E
L
Q
R
L
N
K
V
A
G
E
L
G
V
K
A
P
I
S
L
R
I
N
P
D
V
D
A
K
T
H
P
Y
I
S
T
G
L
R
D
N
K
F
G
--
I
T
F
D
R
A
A
--
Q
V
Y
R
L
A
H
S
L
P
N
L
D
V
H
G
I
D
C
H
I
G
S
Q
L
T
A
L
A
P
F
I
D
A
T
D
R
L
L
A
L
I
D
S
L
K
A
E
G
I
H
I
R
H
L
D
V
G
G
G
L
G
V
V
Y
------
P
Q
---
P
-
S
-
E
--
Y
A
K
A
L
L
D
R
L
----
E
R
------
H
R
D
L
-
E
L
I
F
E
P
G
R
A
I
A
A
N
A
G
V
L
V
T
K
V
E
F
L
K
H
T
--
K
N
F
A
I
I
D
A
A
M
N
D
L
I
R
-------
Q
D
I
I
-
P
--
L
R
P
R
-----
Q
G
E
A
Q
T
Y
D
L
V
-----
G
P
V
C
E
T
S
D
F
L
G
K
D
-------
R
D
-------
L
V
-
L
Q
E
G
D
L
L
A
V
R
S
S
G
A
Y
G
F
T
M
S
S
N
Y
N
T
R
P
R
V
A
E
-
V
M
V
D
G
-
N
K
T
Y
L
V
R
Q
R
E
E
L
S
S
L
W
A
L
E
S
V
L
P
E
--
23
PsiBlast_CBE
75.95
44%
-108
- C2 -
3N2B
1
DCDA_VIBCH
B:
[28-436]
-
F
N
Y
Q
E
DGQLWAEQVP
L
A
D
L
A
N
Q
Y
G
T
P
L
Y
V
Y
S
R
A
T
L
E
R
H
W
H
A
F
D
K
S
V
G
------
D
------
Y
P
H
L
I
C
Y
A
V
K
A
N
S
N
L
G
V
L
N
T
L
A
R
L
G
S
G
F
D
I
V
S
V
G
E
L
E
R
V
L
A
A
G
G
D
----
P
S
K
----
V
V
F
S
G
--
V
G
K
T
E
A
E
M
K
R
A
L
Q
L
K
I
K
C
F
N
V
E
S
E
P
E
L
Q
R
L
N
K
V
A
G
E
L
G
V
K
A
P
I
S
L
R
I
N
P
D
V
----------------
F
G
--
I
T
F
D
R
A
A
--
Q
V
Y
R
L
A
H
S
L
P
N
L
D
V
H
G
I
D
C
H
I
G
-----
L
A
P
F
I
D
A
T
D
R
L
L
A
L
I
D
S
L
K
A
E
G
I
H
I
R
H
L
D
V
G
G
G
L
G
V
V
Y
-----
P
P
Q
---
P
-
S
-
E
--
Y
A
K
A
L
L
D
R
L
----
E
R------
H
R
D
L
-
E
L
I
F
E
P
G
R
A
I
A
A
N
A
G
V
L
V
T
K
V
E
F
L
K
H
T
E
H
K
N
F
A
I
I
D
A
A
M
N
D
L
I
R
P
A
L
Y
Q
A
W
Q
D
I
I
-
P
--
L
R
P
R
Q
----
G
-
E
A
Q
T
Y
D
L
V
-----
G
P
V
C
E
T
S
D
F
L
G
K
D
-------
R
D
-------
L
-
V
L
Q
E
G
D
L
L
A
V
R
S
S
G
A
Y
G
F
T
M
S
S
N
Y
N
T
R
P
R
V
A
E
-
V
M
V
D
G
-
N
K
T
Y
L
V
R
Q
R
E
E
L
S
S
L
W
A
L
E
S
V
L
P
E
--
33
HHSearch
75.39
42%
-96
- C2 -
3VAB
4
?
A:
[39-443]
--
S
L
P
E
-------------
I
A
K
A
V
G
T
P
F
Y
V
Y
S
R
A
T
I
E
R
H
F
R
V
F
H
D
A
F
A
------
D
------
M
D
T
L
V
T
Y
A
L
K
A
N
S
N
Q
A
V
L
T
A
L
A
K
L
G
A
G
A
D
T
V
S
Q
G
E
I
R
R
A
L
A
A
G
I
P
----
A
N
R
----
I
V
F
S
G
--
V
G
K
T
P
R
E
M
D
F
A
L
E
A
G
I
Y
C
F
N
V
E
S
E
P
E
L
E
I
L
S
A
R
A
V
A
A
G
K
V
A
P
V
S
L
R
I
N
P
D
V
D
A
K
T
H
A
K
I
---
K
S
E
N
K
F
G
--
I
P
R
D
K
A
R
--
A
A
Y
A
R
A
A
S
L
P
G
L
N
V
V
G
I
D
M
H
I
G
S
Q
I
I
D
L
E
P
F
D
N
A
F
A
L
M
A
E
L
V
K
E
L
Q
A
D
G
H
N
I
R
H
V
D
V
G
G
G
L
G
I
P
Y
R
T
P
--
P
P
P
---
P
-
V
-
A
--
Y
A
Q
I
V
A
K
H
I
----
K
-------
P
L
G
L
-
K
T
V
F
E
P
G
R
L
I
V
G
N
A
G
L
L
V
T
E
V
I
F
V
K
E
G
D
A
K
N
F
V
I
V
D
A
A
M
N
D
L
I
R
P
T
L
Y
D
A
F
H
D
I
R
-
P
VI
M
P
N
D
-----
N
A
P
R
I
R
A
D
F
V
-----
G
P
V
C
E
T
G
D
Y
L
G
L
D
-------
R
E
-------
V
A
K
P
A
P
G
D
L
I
A
I
C
T
T
G
A
Y
G
A
V
L
S
S
T
Y
N
S
R
L
L
I
P
E
-
V
L
G
D
G
-
E
R
Y
H
V
V
R
P
R
R
T
Y
E
E
L
L
A
L
D
S
V
P
D
W
L
-
5
PsiBlast_PDB
74.51
43%
-95
- C2 -
3VAB
4
?
A:
[42-437]
-----
E
-------------
I
A
K
A
V
G
T
P
F
Y
V
Y
S
R
A
T
I
E
R
H
F
R
V
F
H
D
A
F
A
------
D
------
M
D
T
L
V
T
Y
A
L
K
A
N
S
N
Q
A
V
L
T
A
L
A
K
L
G
A
G
A
D
T
V
S
Q
G
E
I
R
R
A
L
A
A
G
I
P
----
A
N
R
----
I
V
F
S
G
--
V
G
K
T
P
R
E
M
D
F
A
L
E
A
G
I
Y
C
F
N
V
E
S
E
P
E
L
E
I
L
S
A
R
A
V
A
A
G
K
V
A
P
V
S
L
R
I
N
P
D
V
D
A
K
T
H
A
K
I
---
K
S
E
N
K
F
G
--
I
P
R
D
K
A
R
--
A
A
Y
A
R
A
A
S
L
P
G
L
N
V
V
G
I
D
M
H
I
G
S
Q
I
I
D
L
E
P
F
D
N
A
F
A
L
M
A
E
L
V
K
E
L
Q
A
D
G
H
N
I
R
H
V
D
V
G
G
G
L
G
I
P
Y
R
T
P
----
P
---
P
-
P
-
P
V
A
Y
A
Q
I
V
A
K
H
I
----
K
-------
P
L
G
L
-
K
T
V
F
E
P
G
R
L
I
V
G
N
A
G
L
L
V
T
E
V
I
F
V
K
E
G
D
A
K
N
F
V
I
V
D
A
A
M
N
D
L
I
R
P
T
L
Y
D
A
F
H
D
I
R
P
V
--
I
M
P
N
D
----
N
A
P
R
I
R
A
D
F
V
-----
G
P
V
C
E
T
G
D
Y
L
G
L
D
-------
R
E
-------
V
A
K
P
A
P
G
D
L
I
A
I
C
T
T
G
A
Y
G
A
V
L
S
S
T
Y
N
S
R
L
L
I
P
E
-
V
L
G
D
G
-
E
R
Y
H
V
V
R
P
R
R
T
Y
E
E
L
L
A
L
D
S
V
P
D
W
L
-
24
PsiBlast_CBE
74.21
43%
-94
- C2 -
3VAB
2
?
B:
[42-437]
-----
E
-------------
I
A
K
A
V
G
T
P
F
Y
V
Y
S
R
A
T
I
E
R
H
F
R
V
F
H
D
A
F
A
------
D
------
M
D
T
L
V
T
Y
A
L
K
A
N
S
N
Q
A
V
L
T
A
L
A
K
L
G
A
G
A
D
T
V
S
Q
G
E
I
R
R
A
L
A
A
G
I
P
----
A
N
R
----
I
V
F
S
G
--
V
G
K
T
P
R
E
M
D
F
A
L
E
A
G
I
Y
C
F
N
V
E
S
E
P
E
L
E
I
L
S
A
R
A
V
A
A
G
K
V
A
P
V
S
L
R
I
N
P
D
V
D
A
K
T
H
A
K
I
---
K
S
E
N
K
F
G
--
I
P
R
D
K
A
R
--
A
A
Y
A
R
A
A
S
L
P
G
L
N
V
V
G
I
D
M
H
I
G
S
Q
I
I
D
L
E
P
F
D
N
A
F
A
L
M
A
E
L
V
K
E
L
Q
A
D
G
H
N
I
R
H
V
D
V
G
G
G
L
G
I
P
Y
R
T
P
----
P
---
P
-
P
-
P
VA
Y
A
Q
I
V
A
K
H
I
----
K
-------
P
L
G
L
-
K
T
V
F
E
P
G
R
L
I
V
G
N
A
G
L
L
V
T
E
V
I
F
V
K
E
G
D
A
K
N
F
V
I
V
D
A
A
M
N
D
L
I
R
P
T
L
Y
D
A
F
H
D
I
R
P
V
--
I
M
P
N
D
----
N
A
P
R
I
R
A
D
F
V
-----
G
P
V
C
E
T
G
D
Y
L
G
L
D
-------
R
E
-------
V
A
K
P
A
P
G
D
L
I
A
I
C
T
T
G
A
Y
G
A
V
L
S
S
T
Y
N
S
R
L
L
I
P
E
-
V
L
G
D
G
-
E
R
Y
H
V
V
R
P
R
R
T
Y
E
E
L
L
A
L
D
S
V
P
D
W
L
-
7
PsiBlast_PDB
73.89
39%
-95
- C2 -
1TUF
2
DCDA_METJA
A:
[23-423]
-----
E
-------------
L
A
E
K
F
G
T
P
L
Y
V
M
S
E
E
Q
I
K
I
N
Y
N
R
Y
I
E
A
F
K
RWEEET
G
------
K
E
F
I
V
A
Y
A
Y
K
A
N
A
N
L
A
I
T
R
L
L
A
K
L
G
C
G
A
D
V
V
S
G
G
E
L
Y
I
A
K
L
S
N
V
P
----
S
K
K
----
I
V
F
N
G
--
N
C
K
T
K
E
E
I
I
M
G
I
E
A
N
I
R
A
F
N
V
D
S
I
S
E
L
I
L
I
N
E
T
A
K
E
L
G
E
T
A
N
V
A
F
R
I
N
P
N
V
N
P
K
T
H
P
K
I
S
T
G
L
K
K
N
K
F
G
LD
V
E
S
G
I
A
M
--
K
A
I
K
M
A
L
E
M
E
Y
V
N
V
V
G
V
H
C
H
I
G
S
Q
L
T
D
I
S
P
F
I
E
E
T
R
K
V
M
D
F
V
V
E
L
K
E
E
G
I
E
I
E
D
V
N
L
G
G
G
L
G
I
P
Y
Y
K
D
-
K
Q
I
P
---
T
-
Q
K
D
--
L
A
D
A
I
I
N
T
M
L
KYK
D
-------
K
V
E
M
P
N
L
I
L
E
P
G
R
S
L
V
A
T
A
G
Y
L
L
G
K
V
H
H
I
K
E
T
P
V
T
K
W
V
M
I
D
A
G
M
N
D
M
M
R
P
A
M
Y
E
A
Y
H
H
I
I
-
N
--
C
K
V
K
N
----
E
K
E
V
--
V
S
I
A
-----
G
G
L
C
E
S
S
D
V
F
G
R
D
-------
R
E
-------
L
D
K
V
E
V
G
D
V
L
A
I
F
D
V
G
A
Y
G
I
S
M
A
N
N
Y
N
A
R
G
R
P
R
M
-
V
L
T
S
K
-
K
G
V
F
L
I
R
E
R
E
T
Y
A
D
L
I
A
K
D
I
V
P
P
H
L
L
25
PsiBlast_CBE
73.54
40%
-95
- C2 -
1TWI
3
DCDA_METJA
D:
[23-423]
-----
E
-------------
L
A
E
K
F
G
T
P
L
Y
V
M
S
E
E
Q
I
K
I
N
Y
N
R
Y
I
E
A
F
K
RWEEET
G
------
K
E
F
I
V
A
Y
A
Y
K
A
N
A
N
L
A
I
T
R
L
L
A
K
L
G
C
G
A
D
V
V
S
G
G
E
L
Y
I
A
K
L
S
N
V
P
----
S
K
K
----
I
V
F
N
G
--
N
C
K
T
K
E
E
I
I
M
G
I
E
A
N
I
R
A
F
N
V
D
S
I
S
E
L
I
L
I
N
E
T
A
K
E
L
G
E
T
A
N
V
A
F
R
I
N
P
N
V
N
P
K
T
H
P
K
I
S
T
G
L
K
K
N
K
F
G
LD
V
E
S
G
I
A
M
--
K
A
I
K
M
A
L
E
M
E
Y
V
N
V
V
G
V
H
C
H
I
G
S
Q
L
T
D
I
S
P
F
I
E
E
T
R
K
V
M
D
F
V
V
E
L
K
E
E
G
I
E
I
E
D
V
N
L
G
G
G
L
G
I
P
Y
Y
K
D
-
K
Q
I
P
---
T
-
Q
K
D
--
L
A
D
A
I
I
N
T
M
LKYK
D
-------
K
V
E
M
P
N
L
I
L
E
P
G
R
S
L
V
A
T
A
G
Y
L
L
G
K
V
H
H
I
K
E
T
P
V
T
K
W
V
M
I
D
A
G
M
N
D
M
M
R
P
A
M
Y
E
A
Y
H
H
I
I
-
N
--
C
K
V
K
N
----
E
K
E
V
--
V
S
I
A
-----
G
G
L
C
E
S
S
D
V
F
G
R
D
-------
R
E
-------
L
D
K
V
E
V
G
D
V
L
A
I
F
D
V
G
A
Y
G
I
S
M
A
N
N
Y
N
A
R
G
R
P
R
M
-
V
L
T
S
K
-
K
G
V
F
L
I
R
E
R
E
T
Y
A
D
L
I
A
K
D
I
V
P
P
H
L
L
26
PsiBlast_CBE
72.21
40%
-96
- C2 -
1TWI
3
DCDA_METJA
C:
[23-423]
-----
E
-------------
L
A
E
K
F
G
T
P
L
Y
V
M
S
E
E
Q
I
K
I
N
Y
N
R
Y
I
E
A
F
K
RWEEET
G
------
K
E
F
I
V
A
Y
A
Y
K
A
N
A
N
L
A
I
T
R
L
L
A
K
L
G
C
G
A
D
V
V
S
G
G
E
L
Y
I
A
K
L
S
N
V
P
----
S
K
K
----
I
V
F
N
G
--
N
C
K
T
K
E
E
I
I
M
G
I
E
A
N
I
R
A
F
N
V
D
S
I
S
E
L
I
L
I
N
E
T
A
K
E
L
G
E
T
A
N
V
A
F
R
I
N
P
N
V
N
P
K
T
H
P
K
I
S
T
G
L
K
K
N
K
F
G
LD
V
E
S
G
I
A
M
--
K
A
I
K
M
A
L
E
M
E
Y
V
N
V
V
G
V
H
C
H
I
G
S
Q
L
T
D
I
S
P
F
I
E
E
T
R
K
V
M
D
F
V
V
E
L
K
E
E
G
I
E
I
E
D
V
N
L
G
G
G
L
G
I
P
Y
Y
K
D
-
K
Q
I
P
---
T
-
Q
K
D
--
L
A
D
A
I
I
N
T
M
LKYK
D
-------
K
V
E
M
P
N
L
I
L
E
P
G
R
S
L
V
A
T
A
G
Y
L
L
G
K
V
H
H
I
K
E
T
P
V
T
K
W
V
M
I
D
A
G
M
N
D
M
M
R
P
A
M
Y
E
A
Y
H
H
I
I
-
N
--
C
K
V
K
N
----
E
K
E
V
--
V
S
I
A
-----
G
G
L
C
E
S
S
D
V
F
G
R
D
-------
R
E
-------
L
D
K
V
E
V
G
D
V
L
A
I
F
D
V
G
A
Y
G
I
S
M
A
N
N
Y
N
A
R
G
R
P
R
M
-
V
L
T
S
K
-
K
G
V
F
L
I
R
E
R
E
T
Y
A
D
L
I
A
K
D
I
V
P
P
H
L
L
6
PsiBlast_PDB
72.19
40%
-93
- C2 -
1TWI
3
DCDA_METJA
A:
[23-423]
-----
E
-------------
L
A
E
K
F
G
T
P
L
Y
V
M
S
E
E
Q
I
K
I
N
Y
N
R
Y
I
E
A
F
K
R
W
E
E
E
T
G
------
K
E
F
I
V
A
Y
A
Y
K
A
N
A
N
L
A
I
T
R
L
L
A
K
L
G
C
G
A
D
V
V
S
G
G
E
L
Y
I
A
K
L
S
N
V
P
----
S
K
K
----
I
V
F
N
G
--
N
C
K
T
K
E
E
I
I
M
G
I
E
A
N
I
R
A
F
N
V
D
S
I
S
E
L
I
L
I
N
E
T
A
K
E
L
G
E
T
A
N
V
A
F
R
I
N
P
N
V
N
P
K
T
H
P
K
I
S
T
G
L
K
K
N
K
F
G
LD
V
E
S
G
I
A
M
--
K
A
I
K
M
A
L
E
M
E
Y
V
N
V
V
G
V
H
C
H
I
G
S
Q
L
T
D
I
S
P
F
I
E
E
T
R
K
V
M
D
F
V
V
E
L
K
E
E
G
I
E
I
E
D
V
N
L
G
G
G
L
G
I
P
Y
Y
K
D
-
K
Q
I
P
---
T
-
Q
K
D
--
L
A
D
A
I
I
N
T
M
L
K
Y
K
D
-------
K
V
E
M
P
N
L
I
L
E
P
G
R
S
L
V
A
T
A
G
Y
L
L
G
K
V
H
H
I
K
E
T
P
V
T
K
W
V
M
I
D
A
G
M
N
D
M
M
R
P
A
M
Y
E
A
Y
H
H
I
I
-
N
--
C
K
V
K
N
----
E
K
E
V
--
V
S
I
A
-----
G
G
L
C
E
S
S
D
V
F
G
R
D
-------
R
E
-------
L
D
K
V
E
V
G
D
V
L
A
I
F
D
V
G
A
Y
G
I
S
M
A
N
N
Y
N
A
R
G
R
P
R
M
-
V
L
T
S
K
-
K
G
V
F
L
I
R
E
R
E
T
Y
A
D
L
I
A
K
D
I
V
P
P
H
L
L
27
PsiBlast_CBE
72.02
40%
-93
- C2 -
1TWI
3
DCDA_METJA
B:
[23-423]
-----
E
-------------
L
A
E
K
F
G
T
P
L
Y
V
M
S
E
E
Q
I
K
I
N
Y
N
R
Y
I
E
A
F
K
RWEEET
G
------
K
E
F
I
V
A
Y
A
Y
K
A
N
A
N
L
A
I
T
R
L
L
A
K
L
G
C
G
A
D
V
V
S
G
G
E
L
Y
I
A
K
L
S
N
V
P
----
S
K
K
----
I
V
F
N
G
--
N
C
K
T
K
E
E
I
I
M
G
I
E
A
N
I
R
A
F
N
V
D
S
I
S
E
L
I
L
I
N
E
T
A
K
E
L
G
E
T
A
N
V
A
F
R
I
N
P
N
V
N
P
K
T
H
P
K
I
S
T
G
L
K
K
N
K
F
G
LD
V
E
S
G
I
A
M
--
K
A
I
K
M
A
L
E
M
E
Y
V
N
V
V
G
V
H
C
H
I
G
S
Q
L
T
D
I
S
P
F
I
E
E
T
R
K
V
M
D
F
V
V
E
L
K
E
E
G
I
E
I
E
D
V
N
L
G
G
G
L
G
I
P
Y
Y
K
D
-
K
Q
I
P
---
T
-
Q
K
D
--
L
A
D
A
I
I
N
T
M
LKYK
D
-------
K
V
E
M
P
N
L
I
L
E
P
G
R
S
L
V
A
T
A
G
Y
L
L
G
K
V
H
H
I
K
E
T
P
V
T
K
W
V
M
I
D
A
G
M
N
D
M
M
R
P
A
M
Y
E
A
Y
H
H
I
I
-
N
--
C
K
V
K
N
----
E
K
E
V
--
V
S
I
A
-----
G
G
L
C
E
S
S
D
V
F
G
R
D
-------
R
E
-------
L
D
K
V
E
V
G
D
V
L
A
I
F
D
V
G
A
Y
G
I
S
M
A
N
N
Y
N
A
R
G
R
P
R
M
-
V
L
T
S
K
-
K
G
V
F
L
I
R
E
R
E
T
Y
A
D
L
I
A
K
D
I
V
P
P
H
L
L
31
HHSearch
70.30
40%
-87
- C2 -
1TWI
3
DCDA_METJA
A:
[20-433]
--
D
A
I
E
-------------
L
A
E
K
F
G
T
P
L
Y
V
M
S
E
E
Q
I
K
I
N
Y
N
R
Y
I
E
A
F
K
------
R
W
E
E
E
TG
K
E
F
I
V
A
Y
A
Y
K
A
N
A
N
L
A
I
T
R
L
L
A
K
L
G
C
G
A
D
V
V
S
G
G
E
L
Y
I
A
K
L
S
N
V
P
----
S
K
K
----
I
V
F
N
G
--
N
C
K
T
K
E
E
I
I
M
G
I
E
A
N
I
R
A
F
N
V
D
S
I
S
E
L
I
L
I
N
E
T
A
K
E
L
G
E
T
A
N
V
A
F
R
I
N
P
N
V
N
P
K
T
H
P
K
I
S
T
G
L
K
K
N
K
F
G
--
L
D
V
E
S
G
I
A
M
K
A
I
K
M
A
L
E
M
E
Y
V
N
V
V
G
V
H
C
H
I
G
S
Q
L
T
D
I
S
P
F
I
E
E
T
R
K
V
M
D
F
V
V
E
L
K
E
E
G
I
E
I
E
D
V
N
L
G
G
G
L
G
I
P
Y
Y
K
D
K
Q
I
P
T
---
Q
-
K
-
D
--
L
A
D
A
I
I
N
T
M
----
L
K
Y
KDK--
V
E
M
P
-
N
L
I
L
E
P
G
R
S
L
V
A
T
A
G
Y
L
L
G
K
V
H
H
I
K
E
T
P
V
T
K
W
V
M
I
D
A
G
M
N
D
M
M
R
P
A
M
Y
E
A
Y
H
H
I
I
-
N
--
C
K
-
V
-----
K
N
E
K
E
V
V
S
I
A
-----
G
G
L
C
E
S
S
D
V
F
G
R
D
-------
R
E
-------
L
D
K
V
E
V
G
D
V
L
A
I
F
D
V
G
A
Y
G
I
S
M
A
N
N
Y
N
A
R
G
R
P
R
M
-
V
L
T
S
K
-
K
G
V
F
L
I
R
E
R
E
T
Y
A
D
L
I
A
K
D
I
V
P
P
H
L
L
34
HHSearch
67.21
34%
-89
- C2 -
1KNW
5
DCDA_ECOLI
A:
[16-420]
--
N
L
L
R
-------------
L
P
A
E
F
G
C
P
V
W
V
Y
D
A
Q
I
I
R
R
Q
I
A
A
L
K
Q
-
F
D
----------------
V
V
R
F
A
Q
K
A
C
S
N
I
H
I
L
R
L
M
R
E
Q
G
V
K
V
D
S
V
S
L
G
E
I
E
R
A
L
A
A
G
Y
N
PQTH
P
D
D
----
I
V
F
T
A
--
D
V
I
D
Q
A
T
L
E
R
V
S
E
L
Q
I
P
-
V
N
A
G
S
V
D
M
L
D
Q
L
G
Q
V
S
----
P
G
H
R
V
W
L
R
V
N
P
G
F
G
H
G
H
S
Q
K
T
N
T
G
G
E
N
S
K
H
G
--
I
W
Y
T
D
L
P
--
A
A
L
D
V
I
Q
-
R
H
H
L
Q
L
V
G
I
H
M
H
I
G
S
G
V
D
-
Y
A
H
L
E
Q
V
C
G
A
M
V
R
Q
---
V
I
E
F
G
Q
D
L
Q
A
I
S
A
G
G
G
L
S
V
P
Y
Q
Q
G
E
E
A
V
D
T
E
H
Y
-
Y
-
G
--
L
W
N
A
A
R
E
Q
I
----
A
R
H
L
----
G
H
P
V
-
K
L
E
I
E
P
G
R
F
L
V
A
Q
S
G
V
L
I
T
Q
V
R
S
V
K
Q
M
G
S
R
H
F
V
L
V
D
A
G
F
N
D
L
M
R
P
A
M
Y
G
S
Y
H
H
I
S
-
A
--
L
A
A
D
G
RSLE
H
A
P
T
V
E
T
V
V
A
-----
G
P
L
C
E
S
G
D
V
F
T
Q
Q
EG
G
N
V
E
T
R
A
-------
L
P
E
V
K
A
G
D
Y
L
V
L
H
D
T
G
A
Y
G
A
S
M
S
S
N
Y
N
S
R
P
L
L
P
E
-
V
L
F
D
N
-
G
Q
A
R
L
I
R
R
R
Q
T
I
E
E
L
L
A
L
E
L
L
H
H
---
8
PsiBlast_PDB
65.87
37%
-83
- C2 -
2YXX
1
DCDA_THEMA
A:
[9-382]
---------------------
E
I
H
G
T
P
T
Y
V
Y
F
E
E
T
L
R
K
R
S
R
L
V
K
E
V
F
E
------
G
------
V
N
L
L
P
T
F
A
V
K
A
N
N
N
P
V
L
L
K
I
L
R
E
E
G
F
G
M
D
V
V
T
K
G
E
L
L
A
A
K
L
A
G
V
P
----
S
H
T
----
V
V
W
N
G
--
N
G
K
S
R
D
Q
M
E
H
F
L
R
E
D
V
R
I
V
N
V
D
S
F
E
E
M
E
I
W
R
E
L
N
P
E
-
G
V
E
--
Y
F
I
R
V
N
P
E
V
D
A
K
T
H
P
H
I
S
T
G
L
K
K
H
K
F
G
--
I
-
P
L
E
D
L
--
D
S
F
M
E
R
F
R
S
M
N
I
R
--
G
L
H
V
H
I
G
S
Q
I
T
R
V
E
P
F
V
E
A
F
S
K
V
V
R
A
S
E
R
Y
-----
G
F
E
E
I
N
I
G
G
G
W
G
I
N
Y
S
G
E
-
E
-
L
D
---
L
-
S
-
S
--
Y
R
E
K
V
V
P
D
L
----
K
-------
R
F
K
--
R
V
I
V
E
I
G
R
Y
I
V
A
P
S
G
Y
L
L
L
R
V
V
L
V
K
R
R
H
N
K
A
F
V
V
V
D
G
G
M
N
V
L
I
R
P
A
L
Y
S
A
Y
H
R
I
F
-
V
--
L
G
K
Q
G
----
K
E
--
M
R
A
D
V
V
-----
G
P
L
C
E
S
G
D
V
I
A
Y
D
-------
R
E
-------
L
P
E
V
E
P
G
D
I
I
A
V
E
N
A
G
A
Y
G
Y
T
M
S
N
N
Y
N
S
T
T
R
P
A
E
V
L
V
R
E
N
-
G
R
I
S
L
I
R
R
R
E
T
E
M
D
I
F
K
D
V
V
M
-----
28
HHSearch
64.82
37%
-81
- C2 -
2YXX
1
DCDA_THEMA
A:
[2-385]
-
D
I
L
R
K
-------------
V
A
E
I
H
G
T
P
T
Y
V
Y
F
E
E
T
L
R
K
R
S
R
L
V
K
E
V
F
E
------
G
------
V
N
L
L
P
T
F
A
V
K
A
N
N
N
P
V
L
L
K
I
L
R
E
E
G
F
G
M
D
V
V
T
K
G
E
L
L
A
A
K
L
A
G
V
P
----
S
H
T
----
V
V
W
N
G
--
N
G
K
S
R
D
Q
M
E
H
F
L
R
E
D
V
R
I
V
N
V
D
S
F
E
E
M
E
I
W
R
E
L
N
P
---
E
G
V
E
Y
F
I
R
V
N
P
E
V
D
A
K
T
H
P
H
I
S
T
G
L
K
K
H
K
F
G
--
I
P
L
E
D
L
D
--
S
F
M
E
R
F
---
R
S
M
N
I
R
G
L
H
V
H
I
G
S
Q
I
T
R
V
E
P
F
V
E
A
F
S
K
V
V
R
A
S
E
R
Y
---
G
--
F
E
E
I
N
I
G
G
G
W
G
I
N
Y
S
G
--
E
E
L
D
---
L
-
S
-
S
--
Y
R
E
K
V
V
P
D
L
----
K
--------
R
F
K
-
R
V
I
V
E
I
G
R
Y
I
V
A
P
S
G
Y
L
L
L
R
V
V
L
V
K
R
R
H
N
K
A
F
V
V
V
D
G
G
M
N
V
L
I
R
P
A
L
Y
S
A
Y
H
R
I
F
-
V
--
L
G
K
------
Q
G
K
E
M
R
A
D
V
V
-----
G
P
L
C
E
S
G
D
V
I
A
Y
D
-------
R
E
-------
L
P
E
V
E
P
G
D
I
I
A
V
E
N
A
G
A
Y
G
Y
T
M
S
N
N
Y
N
S
T
T
R
P
A
E
-
V
L
V
R
E
N
G
R
I
S
L
I
R
R
R
E
T
E
M
D
I
F
K
D
V
V
M
-----
9
PsiBlast_PDB
62.91
30%
-83
- C2 -
1KNW
5
DCDA_ECOLI
A:
[24-411]
-----------------------
F
G
C
P
V
W
V
Y
D
A
Q
I
I
R
R
Q
I
A
A
L
K
Q
F
-----------------
D
V
V
R
F
A
Q
K
A
C
S
N
I
H
I
L
R
L
M
R
E
Q
G
V
K
V
D
S
V
S
L
G
E
I
E
R
A
L
A
A
G
Y
N
----
P
Q
T
HPDD
I
V
F
T
A
DV
I
D
Q
A
T
L
E
R
V
S
E
L
Q
I
P
V
N
A
G
S
V
D
M
L
D
Q
L
G
Q
V
S
P
-------
G
H
R
V
W
L
R
V
N
P
G
F
G
H
G
H
S
Q
K
T
N
T
G
G
E
N
S
K
H
G
--
I
W
Y
T
D
-
L
--
P
A
A
L
D
V
I
Q
R
H
H
L
Q
L
V
G
I
H
M
H
I
G
S
G
V
----
D
Y
A
H
L
E
Q
V
C
G
A
M
V
R
Q
V
I
E
F
G
Q
D
L
Q
A
I
S
A
G
G
G
L
S
V
P
Y
Q
Q
G
-
E
E
A
V
---
D
-
T
-
E
--
H
Y
Y
G
L
W
N
A
A
----
R
E
Q
I
A
R
H
L
G
H
P
V
-
K
L
E
I
E
P
G
R
F
L
V
A
Q
S
G
V
L
I
T
Q
V
R
S
V
K
Q
M
G
S
R
H
F
V
L
V
D
A
G
F
N
D
L
M
R
P
A
M
Y
G
S
Y
H
H
I
S
-
A
--
L
A
-
A
D
----
G
R
S
L
E
H
A
P
T
V
E
T
V
V
A
G
P
L
C
E
S
G
D
V
F
T
Q
Q
-------
E
G
G
N
V
E
T
R
A
L
P
E
V
K
A
G
D
Y
L
V
L
H
D
T
G
A
Y
G
A
S
M
S
S
N
Y
N
S
R
P
L
L
P
E
-
V
L
F
D
N
-
G
Q
A
R
L
I
R
R
R
Q
T
I
E
E
L
L
A
L
E
L
L
H
H
---
10
PsiBlast_PDB
62.71
30%
-82
- C2 -
1KO0
2
DCDA_ECOLI
A:
[24-411]
-----------------------
F
G
C
P
V
W
V
Y
D
A
Q
I
I
R
R
Q
I
A
A
L
K
Q
F
-----------------
D
V
V
R
F
A
Q
K
A
C
S
N
I
H
I
L
R
L
M
R
E
Q
G
V
K
V
D
S
V
S
L
G
E
I
E
R
A
L
A
A
G
Y
N
----
P
Q
T
HPDD
I
V
F
T
A
DV
I
D
Q
A
T
L
E
R
V
S
E
L
Q
I
P
V
N
A
G
S
V
D
M
L
D
Q
L
G
Q
V
S
P
-------
G
H
R
V
W
L
R
V
N
P
G
F
G
H
G
H
S
Q
K
T
N
T
G
G
E
N
S
K
H
G
--
I
W
Y
T
D
-
L
--
P
A
A
L
D
V
I
Q
R
H
H
L
Q
L
V
G
I
H
M
H
I
G
S
G
V
----
D
Y
A
H
L
E
Q
V
C
G
A
M
V
R
Q
V
I
E
F
G
Q
D
L
Q
A
I
S
A
G
G
G
L
S
V
P
Y
Q
Q
G
-
E
E
A
V
---
D
-
T
-
E
--
H
Y
Y
G
L
W
N
A
A
----
R
E
Q
I
A
R
H
L
G
H
P
V
-
K
L
E
I
E
P
G
R
F
L
V
A
Q
S
G
V
L
I
T
Q
V
R
S
V
K
Q
M
G
S
R
H
F
V
L
V
D
A
G
F
N
D
L
M
R
P
A
M
Y
G
S
Y
H
H
I
S
-
A
--
L
A
-
A
D
----
G
R
S
L
E
H
A
P
T
V
E
T
V
V
A
G
P
L
C
E
S
G
D
V
F
T
Q
Q
-------
E
G
G
N
V
E
T
R
A
L
P
E
V
K
A
G
D
Y
L
V
L
H
D
T
G
A
Y
G
A
S
M
S
S
N
Y
N
S
R
P
L
L
P
E
-
V
L
F
D
N
-
G
Q
A
R
L
I
R
R
R
Q
T
I
E
E
L
L
A
L
E
L
L
-----