@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0846: (2015-12-18 )
MENFLYQLEIKTLGQVFTPKNIVDFMLILKHNHGSVLEPSAGDGSFLKRLKKAVGIEIDPKICPKNALCMDFFDYPLENQFNTIIGNPPYVKHKDIAPSTKEKLHYSLFDERSNLYLFFIEKAIKHLKPKGELIFITPRDFLKSTSSVKLNEWIYKEGTITHFFELGDQKIFPNAMPNCVIFRFCKGDFSRITNDGLQFVCKKGILYFLNQSYTQKLSEVFKVKVGAVSGCDKIFKNETYGNLEFVTSITKRTNVLEKMVFVNKPNDYLLQHKDSLMQRKIKKFNENNWFEWGRMHHISPKKRIYVNAKTHQKNPFFIHQCPNYDGSILALFPYNQNLDLQNLCDKLNAINWQELGFVCDGRFLFSQRSLENALLPKDFLN
Atome Classification :
(20 SA)
.........10........20....---....--30-----.--.......40........50--------...-------......60---...-------------------.....70......--..80........90........100------..--..------------.-------...110.......120.......130.......140..--.....150.......160.......170.......180.......190..------.-----....-----------------------200-.-.---......--.210----.--------......-..220......--.230.-..--...--.240------------........-250...------....260.--------------..--....270------------.--......280-........290...---..---..300.......-310.......-.320.......330...-....340.......-350.......---360...--.....370.......380-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEN
F
L
Y
Q
L
E
I
K
T
LGQVF
T
P
K
N
I
V
D
F
---
M
L
I
L--KH-----N--HGSVLEPSAG
D
G
S
F
L
K
R
L
---------
K
K
A-------VGIEIDPK---ICP-------------------KNA
L
C
M
D
F
FDY
P
L
--EN
Q
F
N
T
IIGNPPYVKHKDIAPS
T
K
-------
E
K
--
L
H
------------
Y
-------
S
L
FDERS
N
L
Y
L
F
F
I
E
K
A
I
K
HLKPKG
E
L
I
F
I
T
P
R
D
F
LKS--TSSVKLN
E
W
I
YKEG
T
I
T
H
F
F
ELGDQKIFPNAMPN
C
V
I
F
R
FCK
G
D
F
S
R
ITN------D-----
G
L
Q
F
-----------------------
V
---
C
-
K
---
K
G
I
L
Y
F
--LN------
Q
--------
S
Y
T
Q
K
L
-
S
E
V
F
K
V
K
VGAV--S
G
C
D
K
-
I
F--KNE--TYG-------------
N
L
E
F
V
T
S
I
-
T
K
R
T
N
V
------
L
E
K
M
V
F
VN--------------KP--
N
D
Y
L
L
Q
H
------------
K
--
D
S
L
M
Q
R
K
I
--
K
K
FNENN
W
F
EWGRM---HH---ISPK
K
R
I
Y
V
N
AK-T-HQKN
P
F
F
I
-HQCPNYDG
S
I
L
A
L
F
PYN-QNL
D
L
Q
N
L
C
D
K
LNA-I
N
W
Q
E
L
G
F
V
C---D-
G
R
F
L
--
F
S
QR
S
L
E
NALLP
K
D
FLN--
32
HHSearch
85.84
25%
-73
* C3 *
2IH2
5
MTTA_THEAQ
A:
[21-409]
---------------
V
E
T
P
P
E
V
V
D
F
---
M
V
S
L
--
A
E
-----
A
P
R
G
G
R
V
L
E
P
A
C
A
H
G
P
F
L
R
A
F
R
E
A
HGTA--
Y
R
F
-------
V
G
V
E
I
D
P
K
---
A
L
D
L
P
PW---------------
A
E
G
I
L
A
D
F
L
L
W
E
P
--
G
E
A
F
D
L
I
L
G
N
P
P
Y
G
I
V
G
E
A
S
K
Y
P
I
H
V
F
K
A
V
K
D
L
Y
K
K
A
------------
F
-------
S
T
W
K
G
K
Y
N
L
Y
G
A
F
L
E
K
A
V
R
L
L
K
P
G
G
V
L
V
F
V
V
P
A
T
W
L
V
L
--
E
D
F
A
L
L
R
E
F
L
A
R
E
G
K
T
-
S
V
Y
Y
L
G
--
E
V
F
P
Q
K
K
V
S
A
V
V
I
R
F
Q
K
S
G
K
G
L
S
L
W
------
D
T
Q
E
S
-
E
S
G
F
T
P
I
--------------------
L
W
A
E
Y
P
H
WE-
G
E
I
I
R
F
--
E
T
E
E
T
R
K
L
E
--------
I
S
G
M
P
L
-
G
D
L
F
H
I
R
F
A
A
R
--
S
P
E
F
K
-
K
H
PA
V
R
K
EP
G
P
G
-------------
L
V
P
V
L
T
G
R
-
N
L
K
P
G
W
------
V
D
Y
E
----------------------
K
N
H
S
---------------------------------
G
L
W
M
P
K
E
R
A
KEL
R
D
---
F
Y
A
T
P
H
L
V
V
A
H
T
K
G
-
T
R
V
V
A
A
W
D
--
E
R
A
Y
P
W
R
E
E
F
H
L
L
P
K
E
G
V
R
L
D
P
S
S
L
V
Q
W
L
N
S
E
A
M
Q
K
H
V
R
T
L
Y
---
R
D
F
V
P
H
--
L
T
L
R
M
L
E
R
L
P
V
R
R
E
Y
G
F
--
55
Fugue
83.85
22%
-66
- C3 -
2ADM
1
MTTA_THEAQ
A:
[21-413]
---------------
V
E
T
P
P
E
V
V
D
F
---
M
V
S
L
A
E
A
P
-----
R
--
G
G
R
V
L
E
P
A
C
A
H
G
P
F
L
R
A
F
---------
R
E
A
HGTG
Y
R
F
V
G
V
E
I
D
P
K
---
A
L
D
LPPW---------------
A
E
G
I
L
A
D
F
L
L
W
E
P
--
G
E
A
F
D
L
I
L
G
N
P
P
Y
G
I
V
G
V
F
K
A
V
K
D
-------
L
Y
--
K
K
A
-----------
F
-------
S
T
W
K
G
K
Y
N
L
Y
G
A
F
L
E
K
A
V
R
L
L
K
P
G
G
V
L
V
F
V
V
P
A
T
W
L
V
L
--
E
D
F
A
L
L
R
E
F
L
A
R
E
G
K
T
S
V
Y
Y
L
---
G
E
V
F
P
Q
K
K
V
S
A
V
V
I
R
F
Q
K
S
G
----
K
G
------
L
-----
S
L
W
D
-----------------------
T
---
Q
-
E
---
S
E
S
G
F
T
--
P
I
------
L
--------
W
A
E
Y
P
H
-
W
E
G
E
I
I
R
F
E
T
E
--
E
T
R
K
L
-
E
I
--
S
G
M
--
P
L
G
-------------
D
L
F
H
I
R
F
A
-
A
R
S
P
E
F
------
K
K
H
P
A
V
R
K
--------------
E
P
--
G
P
G
L
V
P
V
------------
L
TG
R
N
L
K
P
G
W
V
DY
E
K
N
H
S
G
L
W
M
P
K
E
R
A
---
K
E
LRD
F
Y
A
T
P
H
L
V
V
A
H
T
-
K
-
G
T
R
V
V
A
A
W
D
E
R
A
Y
P
W
R
E
E
F
H
L
L
P
K
E
G
-
V
R
L
D
P
S
T
L
V
Q
W
L
N
S
-
E
A
M
Q
K
H
V
R
T
L
---
Y
-
R
D
F
V
PH
L
T
L
R
M
L
E
R
L
P
V
R
R
E
Y
G
F
HT
31
HHSearch
70.98
15%
-62
- C3 -
3S1S
16
?
A:
[289-807]
-------
R
G
R
G
H
E
G
V
V
P
T
D
I
E
L
G
K
V
L
S
I
I
S
Q
H
--
I
L
G
R
P
L
T
E
--
D
E
V
I
S
D
P
A
A
G
S
G
N
L
L
A
T
V
S
A
G
FNNVMP
R
Q
I
-------
W
A
N
D
I
E
T
L
---
F
L
E
L
L
S
I
R
L
G
L
L
FPQLVSSN
N
A
P
T
I
T
G
E
D
V
C
S
L
N
P
ED
F
A
N
V
S
V
V
V
M
N
P
P
Y
V
S
G
V
T
D
P
A
I
K
R
-------
K
F
--
A
H
K
I
----------
I
Q
L
TGNRP
Q
T
L
F
G
Q
I
G
V
E
A
L
F
L
E
L
V
T
E
L
V
Q
D
G
T
V
I
S
A
I
M
P
K
Q
Y
L
T
A
QG
N
E
S
K
A
F
R
E
F
L
V
G
N
F
G
L
E
H
I
F
L
Y
P
R
E
G
L
F
E
E
V
I
K
D
T
V
V
F
V
G
R
K
G
S
S
V
E
E
I
E
V
L
D
S
FT
P
LEQVD
L
H
N
L
K
R
A
L
S
N
SSNE
Q
I
I
Q
P
M
G
M
E
L
R
K
E
K
R
E
E
L
-
E
N
R
V
T
V
G
W
R
H
IT
S
N
G
R
V
A
--
E
E
W
I
T
N
NLE
S
H
C
I
R
L
V
A
S
D
Y
D
L
R
R
G
R
V
GN
K
G
A
S
D
L
L
F
--
I
N
S
--
K
K
K
L
W
D
L
LDESVPRDW
L
Y
P
A
L
R
K
V
N
E
I
N
T
P
I
FNEDAT
P
V
R
F
L
C
P
P
NSAYQDGT
G
E
S
I
I
L
D
K
I
L
D
V
Y
V
D
F
Q
V
Y
K
SKQKKFEKS
K
--
E
E
L
K
E
I
-----
L
Y
K
E
S
D
F
Y
S
S
E
--------------
H
T
V
F
I
P
R
A
-
L
R
R
S
A
R
A
F
I
N
-
E
Q
K
V
F
C
S
T
N
A
L
E
V
F
G
G
N
--
S
E
E
M
W
L
L
L
S
W
L
S
S
V
F
A
Q
L
Q
F
E
A
M
A
K
DQ
E
-
G
E
R
K
--
L
E
K
K
S
I
Q
N
L
Y
I
P
N
L
G
D
I
--
2
PsiBlast_PDB
70.74
32%
-136
- C3 -
1AQI
1
MTTA_THEAQ
A:
[21-210]
---------------
V
E
T
P
P
E
V
V
D
F
---
M
V
S
L
--
A
E
A
P
---
R
--
G
G
R
V
L
E
P
A
C
A
H
G
P
F
L
R
A
F
---------
R
E
A
HGTG
Y
R
F
V
G
V
E
I
D
P
K
A
L
D
L
P
P
W------------------
A
E
G
I
L
A
D
F
L
L
W
E
P
--
G
E
A
F
D
L
I
L
G
N
P
P
Y
---
G
I
V
------------------KAV
K
D
L
Y
K
K
A
--
F
-------
S
T
W
K
G
K
Y
N
L
Y
G
A
F
L
E
K
A
V
R
L
L
K
P
G
G
V
L
V
F
V
V
P
A
T
W
L
V
L
--
E
D
F
A
L
L
R
E
F
L
A
R
E
G
K
T
S
V
Y
Y
-
L
G
E
--
V
F
P
Q
K
K
V
S
A
V
V
I
R
F
Q
K
S
G
K
G
L
S
L
W
------
D
-----
T
Q
E
S
-----------------------
E
---
S
-
G
---
F
T
P
I
L
W
--
A
E
------
Y
--------
P
H
W
E
G
E
-
I
I
R
F
E
T
E
E
T
R
K
--
L
E
I
S
G
-
M
P
--
L
G
D
--
L
F
H
-------------
I
R
F
A
A
R
S
P
-
E
F
K
K
H
P
------
A
V
R
K
E
P
G
P
--------------
G
L
--
V
P
V
L
T
G
R
------------
N
--
L
K
P
G
W
V
D
Y
--
E
K
N
H
S
G
L
W
M
P
K
E
R
A
---
K
E
---
L
R
D
F
Y
A
T
P
H
L
V
V
-
A
-
H
T
K
G
T
R
V
V
-
A
A
W
D
E
R
A
Y
P
W
R
E
E
F
H
L
L
-
P
K
E
G
V
R
L
D
P
S
T
L
V
Q
-
W
L
N
S
E
A
M
Q
K
H
---
V
-
R
T
L
Y
--
R
D
F
V
P
H
L
T
L
R
M
L
E
R
L
P
V
--
21
PsiBlast_CBE
70.60
32%
-134
- C3 -
1AQJ
1
MTTA_THEAQ
B:
[21-210]
---------------
V
E
T
P
P
E
V
V
D
F
---
M
V
S
L
--
A
E
A
P
---
R
--
G
G
R
V
L
E
P
A
C
A
H
G
P
F
L
R
A
F
---------
R
E
A
HGTG
Y
R
F
V
G
V
E
I
D
P
K
ALD
L
P
P
W------------------
A
E
G
I
L
A
D
F
L
L
W
E
P
--
G
E
A
F
D
L
I
L
G
N
P
P
Y
---
G
I
V
------------------FK
A
V
K
D
L
Y
K
K
A
-
F
-------
S
T
W
K
G
K
Y
N
L
Y
G
A
F
L
E
K
A
V
R
L
L
K
P
G
G
V
L
V
F
V
V
P
A
T
W
L
V
L
--
E
D
F
A
L
L
R
E
F
L
A
R
E
G
K
T
S
V
Y
Y
-
L
G
E
--
V
F
P
Q
K
K
V
S
A
V
V
I
R
F
Q
K
S
G
K
G
L
S
L
W
------
D
-----
T
Q
E
S
-----------------------
E
---
S
-
G
---
F
T
P
I
L
W
--
A
E
------
Y
--------
P
H
W
E
G
E
-
I
I
R
F
E
T
E
E
T
R
K
--
L
E
I
S
G
-
M
P
--
L
G
D
--
L
F
H
-------------
I
R
F
A
A
R
S
P
-
E
F
K
K
H
P
------
A
V
R
K
E
P
G
P
--------------
G
L
--
V
P
V
L
T
G
R
------------
N
--
L
K
P
G
W
V
D
Y
--
E
K
N
H
S
G
L
W
M
P
K
E
R
A
---
K
E
---
L
R
D
F
Y
A
T
P
H
L
V
V
-
A
-
H
T
K
G
T
R
V
V
-
A
A
W
D
E
R
A
Y
P
W
R
E
E
F
H
L
L
-
P
K
E
G
V
R
L
D
P
S
S
L
V
Q
-
W
L
N
S
E
A
M
Q
K
H
---
V
-
R
T
L
Y
--
R
D
F
V
P
H
L
T
L
R
M
L
E
R
L
P
V
--
1
PsiBlast_PDB
70.53
32%
-135
- C3 -
1AQJ
1
MTTA_THEAQ
A:
[21-210]
---------------
V
E
T
P
P
E
V
V
D
F
---
M
V
S
L
--
A
E
A
P
---
R
--
G
G
R
V
L
E
P
A
C
A
H
G
P
F
L
R
A
F
---------
R
E
A
HGTG
Y
R
F
V
G
V
E
I
D
P
K
A
L
D
L
P
P
W------------------
A
E
G
I
L
A
D
F
L
L
W
E
P
--
G
E
A
F
D
L
I
L
G
N
P
P
Y
---
G
I
V
------------------A
V
K
D
L
Y
K
K
A
---
F
-------
S
T
W
K
G
K
Y
N
L
Y
G
A
F
L
E
K
A
V
R
L
L
K
P
G
G
V
L
V
F
V
V
P
A
T
W
L
V
L
--
E
D
F
A
L
L
R
E
F
L
A
R
E
G
K
T
S
V
Y
Y
-
L
G
E
--
V
F
P
Q
K
K
V
S
A
V
V
I
R
F
Q
K
S
G
K
G
L
S
L
W
------
D
-----
T
Q
E
S
-----------------------
E
---
S
-
G
---
F
T
P
I
L
W
--
A
E
------
Y
--------
P
H
W
E
G
E
-
I
I
R
F
E
T
E
E
T
R
K
--
L
E
I
S
G
-
M
P
--
L
G
D
--
L
F
H
-------------
I
R
F
A
A
R
S
P
-
E
F
K
K
H
P
------
A
V
R
K
E
P
G
P
--------------
G
L
--
V
P
V
L
T
G
R
------------
N
--
L
K
P
G
W
V
D
Y
--
E
K
N
H
S
G
L
W
M
P
K
E
R
A
---
K
E
---
L
R
D
F
Y
A
T
P
H
L
V
V
-
A
-
H
T
K
G
T
R
V
V
-
A
A
W
D
E
R
A
Y
P
W
R
E
E
F
H
L
L
-
P
K
E
G
V
R
L
D
P
S
S
L
V
Q
-
W
L
N
S
E
A
M
Q
K
H
---
V
-
R
T
L
Y
--
R
D
F
V
P
H
L
T
L
R
M
L
E
R
L
P
V
--
28
PsiBlast_CBE
70.36
32%
-131
- C3 -
2ADM
1
MTTA_THEAQ
B:
[21-210]
---------------
V
E
T
P
P
E
V
V
D
F
---
M
V
S
L
--
A
E
AP---
R
--
G
G
R
V
L
E
P
A
C
A
H
G
P
F
L
R
A
F
---------
R
E
A
HGTGYRF
V
G
V
E
I
D
P
K
ALD
L
P
P
W------------------
A
E
G
I
L
A
D
F
L
L
W
E
P
--
G
E
A
F
D
L
I
L
G
N
P
P
Y
---
G
I
V
G
-----------------VFKAVKDLYKKA
F
-------
S
T
W
K
G
K
Y
N
L
Y
G
A
F
L
E
K
A
V
R
L
L
K
P
G
G
V
L
V
F
V
V
P
A
T
W
L
V
L
--
E
D
F
A
L
L
R
E
F
L
A
R
E
G
K
T
S
V
Y
Y
-
L
G
E
--
V
F
P
Q
K
K
V
S
A
V
V
I
R
F
Q
K
S
G
K
G
L
S
L
W
------
D
-----
T
Q
E
S
-----------------------
E
---
S
-
G
---
F
T
P
I
L
W
--
A
E
------
Y
--------
P
H
W
E
G
E
-
I
I
R
F
E
T
E
E
T
R
K
--
L
E
I
S
G
-
M
P
--
L
G
D
--
L
F
H
-------------
I
R
F
A
A
R
S
P
-
E
F
K
K
H
P
------
A
V
R
K
E
P
G
P
--------------
G
L
--
V
P
V
L
T
G
R
------------
N
--
L
K
P
G
W
V
D
Y
--
E
K
N
H
S
G
L
W
M
P
K
E
R
A
---
K
E
---
L
R
D
F
Y
A
T
P
H
L
V
V
-
A
-
H
T
K
G
T
R
V
V
-
A
A
W
D
E
R
A
Y
P
W
R
E
E
F
H
L
L
-
P
K
E
G
V
R
L
D
P
S
T
L
V
Q
-
W
L
N
S
E
A
M
Q
K
H
---
V
-
R
T
L
Y
--
R
D
F
V
P
H
L
T
L
R
M
L
E
R
L
P
V
--
29
PsiBlast_CBE
69.96
32%
-135
- C3 -
1AQI
1
MTTA_THEAQ
B:
[21-210]
---------------
V
E
T
P
P
E
V
V
D
F
---
M
V
S
L
--
A
E
AP---
R
--
G
G
R
V
L
E
P
A
C
A
H
G
P
F
L
R
A
F
---------
R
E
A
HGTGYRF
V
G
V
E
I
D
P
K
ALD
L
P
P
W------------------
A
E
G
I
L
A
D
F
L
L
W
E
P
--
G
E
A
F
D
L
I
L
G
N
P
P
Y
---
G
I
V
------------------KAVKDLYKKA--
F
-------
S
T
W
K
G
K
Y
N
L
Y
G
A
F
L
E
K
A
V
R
L
L
K
P
G
G
V
L
V
F
V
V
P
A
T
W
L
V
L
--
E
D
F
A
L
L
R
E
F
L
A
R
E
G
K
T
S
V
Y
Y
-
L
G
E
--
V
F
P
Q
K
K
V
S
A
V
V
I
R
F
Q
K
S
G
K
G
L
S
L
W
------
D
-----
T
Q
E
S
-----------------------
E
---
S
-
G
---
F
T
P
I
L
W
--
A
E
------
Y
--------
P
H
W
E
G
E
-
I
I
R
F
E
T
E
E
T
R
K
--
L
E
I
S
G
-
M
P
--
L
G
D
--
L
F
H
-------------
I
R
F
A
A
R
S
P
-
E
F
K
K
H
P
------
A
V
R
K
E
P
G
P
--------------
G
L
--
V
P
V
L
T
G
R
------------
N
--
L
K
P
G
W
V
D
Y
--
E
K
N
H
S
G
L
W
M
P
K
E
R
A
---
K
E
---
L
R
D
F
Y
A
T
P
H
L
V
V
-
A
-
H
T
K
G
T
R
V
V
-
A
A
W
D
E
R
A
Y
P
W
R
E
E
F
H
L
L
-
P
K
E
G
V
R
L
D
P
S
T
L
V
Q
-
W
L
N
S
E
A
M
Q
K
H
---
V
-
R
T
L
Y
--
R
D
F
V
P
H
L
T
L
R
M
L
E
R
L
P
V
--
3
PsiBlast_PDB
69.92
32%
-131
- C3 -
2ADM
1
MTTA_THEAQ
A:
[21-210]
---------------
V
E
T
P
P
E
V
V
D
F
---
M
V
S
L
--
A
E
A
P
---
R
--
G
G
R
V
L
E
P
A
C
A
H
G
P
F
L
R
A
F
---------
R
E
A
HGTG
Y
R
F
V
G
V
E
I
D
P
K
ALD
L
P
P
W------------------
A
E
G
I
L
A
D
F
L
L
W
E
P
--
G
E
A
F
D
L
I
L
G
N
P
P
Y
---
G
I
V
G
-----------------V
F
K
A
V
K
D
L
Y
K
K
A
F
-------
S
T
W
K
G
K
Y
N
L
Y
G
A
F
L
E
K
A
V
R
L
L
K
P
G
G
V
L
V
F
V
V
P
A
T
W
L
V
L
--
E
D
F
A
L
L
R
E
F
L
A
R
E
G
K
T
S
V
Y
Y
-
L
G
E
--
V
F
P
Q
K
K
V
S
A
V
V
I
R
F
Q
K
S
G
K
G
L
S
L
W
------
D
-----
T
Q
E
S
-----------------------
E
---
S
-
G
---
F
T
P
I
L
W
--
A
E
------
Y
--------
P
H
W
E
G
E
-
I
I
R
F
E
T
E
E
T
R
K
--
L
E
I
S
G
-
M
P
--
L
G
D
--
L
F
H
-------------
I
R
F
A
A
R
S
P
-
E
F
K
K
H
P
------
A
V
R
K
E
P
G
P
--------------
G
L
--
V
P
V
L
T
G
R
------------
N
--
L
K
P
G
W
V
D
Y
--
E
K
N
H
S
G
L
W
M
P
K
E
R
A
---
K
E
---
L
R
D
F
Y
A
T
P
H
L
V
V
-
A
-
H
T
K
G
T
R
V
V
-
A
A
W
D
E
R
A
Y
P
W
R
E
E
F
H
L
L
-
P
K
E
G
V
R
L
D
P
S
T
L
V
Q
-
W
L
N
S
E
A
M
Q
K
H
---
V
-
R
T
L
Y
--
R
D
F
V
P
H
L
T
L
R
M
L
E
R
L
P
V
--
26
PsiBlast_CBE
69.89
32%
-125
- C3 -
2IBT
7
MTTA_THEAQ
D:
[21-210]
---------------
V
E
T
P
P
E
V
V
D
F
---
M
V
S
L
--
A
E
AP---
R
--
G
G
R
V
L
E
P
A
C
A
H
G
P
F
L
R
A
F
---------
R
E
A
HGTAYRF
V
G
V
E
I
D
P
K
ALD
L
P
P
W------------------
A
E
G
I
L
A
D
F
L
L
W
E
P
--
G
E
A
F
D
L
I
L
G
N
P
P
Y
---
G
I
V
G
E
A
S
K
-------
Y
P
--
I
H
VFKAVKDLYKKA
F
-------
S
T
W
K
G
K
Y
N
L
Y
G
A
F
L
E
K
A
V
R
L
L
K
P
G
G
V
L
V
F
V
V
P
A
T
W
L
V
L
--
E
D
F
A
L
L
R
E
F
L
A
R
E
G
K
T
S
V
Y
Y
-
L
G
E
--
V
F
P
Q
K
K
V
S
A
V
V
I
R
F
Q
K
S
G
K
G
L
S
L
W
------
D
-----
T
Q
E
S
-----------------------
E
---
S
-
G
---
F
T
P
I
L
W
--
A
E
------
Y
--------
P
H
W
E
G
E
-
I
I
R
F
E
T
E
E
T
R
K
--
L
E
I
S
G
-
M
P
--
L
G
D
--
L
F
H
-------------
I
R
F
A
A
R
S
P
-
E
F
K
K
H
P
------
A
V
R
K
E
P
G
P
--------------
G
L
--
V
P
V
L
T
G
R
------------
N
--
L
K
P
G
W
V
D
Y
--
E
K
N
H
S
G
L
W
M
P
K
E
R
A
---
K
E
---
L
R
D
F
Y
A
T
P
H
L
V
V
-
A
-
H
T
K
G
T
R
V
V
-
A
A
W
D
E
R
A
Y
P
W
R
E
E
F
H
L
L
-
P
K
E
G
V
R
L
D
P
S
S
L
V
Q
-
W
L
N
S
E
A
M
Q
K
H
---
V
-
R
T
L
Y
--
R
D
F
V
P
H
L
T
L
R
M
L
E
R
L
P
V
--
24
PsiBlast_CBE
69.74
32%
-121
- C3 -
2IH4
4
MTTA_THEAQ
D:
[21-210]
---------------
V
E
T
P
P
E
V
V
D
F
---
M
V
S
L
--
A
E
AP---
R
--
G
G
R
V
L
E
P
A
C
A
H
G
P
F
L
R
A
F
---------
R
E
A
HGTAYRF
V
G
V
E
I
D
P
K
ALD
L
P
P
W------------------
A
E
G
I
L
A
D
F
L
L
W
E
P
--
G
E
A
F
D
L
I
L
G
N
P
P
Y
---
G
I
V
G
E
A
S
K
-------
Y
P
--
I
H
VFKAVKDLYKKA
F
-------
S
T
W
K
G
K
Y
N
L
Y
G
A
F
L
E
K
A
V
R
L
L
K
P
G
G
V
L
V
F
V
V
P
A
T
W
L
V
L
--
E
D
F
A
L
L
R
E
F
L
A
R
E
G
K
T
S
V
Y
Y
-
L
G
E
--
V
F
P
Q
K
K
V
S
A
V
V
I
R
F
Q
K
S
G
K
G
L
S
L
W
------
D
-----
T
Q
E
S
-----------------------
E
---
S
-
G
---
F
T
P
I
L
W
--
A
E
------
Y
--------
P
H
W
E
G
E
-
I
I
R
F
E
T
E
E
T
R
K
--
L
E
I
S
G
-
M
P
--
L
G
D
--
L
F
H
-------------
I
R
F
A
A
R
S
P
-
E
F
K
K
H
P
------
A
V
R
K
E
P
G
P
--------------
G
L
--
V
P
V
L
T
G
R
------------
N
--
L
K
P
G
W
V
D
Y
--
E
K
N
H
S
G
L
W
M
P
K
E
R
A
---
K
E
---
L
R
D
F
Y
A
T
P
H
L
V
V
-
A
-
H
T
K
G
T
R
V
V
-
A
A
W
D
E
R
A
Y
P
W
R
E
E
F
H
L
L
-
P
K
E
G
V
R
L
D
P
S
S
L
V
Q
-
W
L
N
S
E
A
M
Q
K
H
---
V
-
R
T
L
Y
--
R
D
F
V
P
H
L
T
L
R
M
L
E
R
L
P
V
--
9
PsiBlast_PDB
69.74
32%
-125
- C3 -
2IH5
4
MTTA_THEAQ
A:
[21-210]
---------------
V
E
T
P
P
E
V
V
D
F
---
M
V
S
L
--
A
E
A
P
---
R
--
G
G
R
V
L
E
P
A
C
A
H
G
P
F
L
R
A
F
---------
R
E
A
HGTA
Y
R
F
V
G
V
E
I
D
P
K
A
L
D
L
P
P
W------------------
A
E
G
I
L
A
D
F
L
L
W
E
P
--
G
E
A
F
D
L
I
L
G
N
P
P
Y
---
G
I
V
G
E
A
S
K
-------
Y
P
--
I
H
V
F
K
A
V
K
D
L
Y
K
K
A
F
-------
S
T
W
K
G
K
Y
N
L
Y
G
A
F
L
E
K
A
V
R
L
L
K
P
G
G
V
L
V
F
V
V
P
A
T
W
L
V
L
--
E
D
F
A
L
L
R
E
F
L
A
R
E
G
K
T
S
V
Y
Y
-
L
G
E
--
V
F
P
Q
K
K
V
S
A
V
V
I
R
F
Q
K
S
G
K
G
L
S
L
W
------
D
-----
T
Q
E
S
-----------------------
E
---
S
-
G
---
F
T
P
I
L
W
--
A
E
------
Y
--------
P
H
W
E
G
E
-
I
I
R
F
E
T
E
E
T
R
K
--
L
E
I
S
G
-
M
P
--
L
G
D
--
L
F
H
-------------
I
R
F
A
A
R
S
P
-
E
F
K
K
H
P
------
A
V
R
K
E
P
G
P
--------------
G
L
--
V
P
V
L
T
G
R
------------
N
--
L
K
P
G
W
V
D
Y
--
E
K
N
H
S
G
L
W
M
P
K
E
R
A
---
K
E
---
L
R
D
F
Y
A
T
P
H
L
V
V
-
A
-
H
T
K
G
T
R
V
V
-
A
A
W
D
E
R
A
Y
P
W
R
E
E
F
H
L
L
-
P
K
E
G
V
R
L
D
P
S
S
L
V
Q
-
W
L
N
S
E
A
M
Q
K
H
---
V
-
R
T
L
Y
--
R
D
F
V
P
H
L
T
L
R
M
L
E
R
L
P
V
--
22
PsiBlast_CBE
69.50
32%
-121
- C3 -
2NP6
5
MTTA_THEAQ
D:
[21-210]
---------------
V
E
T
P
P
E
V
V
D
F
---
M
V
S
L
--
A
E
AP---
R
--
G
G
R
V
L
E
P
A
C
A
H
G
P
F
L
R
A
F
---------
R
E
A
HGTAYRF
V
G
V
E
I
D
P
K
ALD
L
P
P
W------------------
A
E
G
I
L
A
D
F
L
L
W
E
P
--
G
E
A
F
D
L
I
L
G
N
P
P
Y
---
G
I
V
G
E
A
S
K
-------
Y
P
--
I
H
VFKAVKDLYKKA
F
-------
S
T
W
K
G
K
Y
N
L
Y
G
A
F
L
E
K
A
V
R
L
L
K
P
G
G
V
L
V
F
V
V
P
A
T
W
L
V
L
--
E
D
F
A
L
L
R
E
F
L
A
R
E
G
K
T
S
V
Y
Y
-
L
G
E
--
V
F
P
Q
K
K
V
S
A
V
V
I
R
F
Q
K
S
G
K
G
L
S
L
W
------
D
-----
T
Q
E
S
-----------------------
E
---
S
-
G
---
F
T
P
I
L
W
--
A
E
------
Y
--------
P
H
W
E
G
E
-
I
I
R
F
E
T
E
E
T
R
K
--
L
E
I
S
G
-
M
P
--
L
G
D
--
L
F
H
-------------
I
R
F
A
A
R
S
P
-
E
F
K
K
H
P
------
A
V
R
K
E
P
G
P
--------------
G
L
--
V
P
V
L
T
G
R
------------
N
--
L
K
P
G
W
V
D
Y
--
E
K
N
H
S
G
L
W
M
P
K
E
R
A
---
K
E
---
L
R
D
F
Y
A
T
P
H
L
V
V
-
A
-
H
T
K
G
T
R
V
V
-
A
A
W
D
E
R
A
Y
P
W
R
E
E
F
H
L
L
-
P
K
E
G
V
R
L
D
P
S
S
L
V
Q
-
W
L
N
S
E
A
M
Q
K
H
---
V
-
R
T
L
Y
--
R
D
F
V
P
H
L
T
L
R
M
L
E
R
L
P
V
--
8
PsiBlast_PDB
69.48
32%
-123
- C3 -
2IH4
4
MTTA_THEAQ
A:
[21-210]
---------------
V
E
T
P
P
E
V
V
D
F
---
M
V
S
L
--
A
E
A
P
---
R
--
G
G
R
V
L
E
P
A
C
A
H
G
P
F
L
R
A
F
---------
R
E
A
HGTA
Y
R
F
V
G
V
E
I
D
P
K
ALD
L
P
P
W------------------
A
E
G
I
L
A
D
F
L
L
W
E
P
--
G
E
A
F
D
L
I
L
G
N
P
P
Y
---
G
I
V
G
E
A
S
K
-------
Y
P
--
I
H
VF
K
A
V
K
D
L
Y
K
K
A
F
-------
S
T
W
K
G
K
Y
N
L
Y
G
A
F
L
E
K
A
V
R
L
L
K
P
G
G
V
L
V
F
V
V
P
A
T
W
L
V
L
--
E
D
F
A
L
L
R
E
F
L
A
R
E
G
K
T
S
V
Y
Y
-
L
G
E
--
V
F
P
Q
K
K
V
S
A
V
V
I
R
F
Q
K
S
G
K
G
L
S
L
W
------
D
-----
T
Q
E
S
-----------------------
E
---
S
-
G
---
F
T
P
I
L
W
--
A
E
------
Y
--------
P
H
W
E
G
E
-
I
I
R
F
E
T
E
E
T
R
K
--
L
E
I
S
G
-
M
P
--
L
G
D
--
L
F
H
-------------
I
R
F
A
A
R
S
P
-
E
F
K
K
H
P
------
A
V
R
K
E
P
G
P
--------------
G
L
--
V
P
V
L
T
G
R
------------
N
--
L
K
P
G
W
V
D
Y
--
E
K
N
H
S
G
L
W
M
P
K
E
R
A
---
K
E
---
L
R
D
F
Y
A
T
P
H
L
V
V
-
A
-
H
T
K
G
T
R
V
V
-
A
A
W
D
E
R
A
Y
P
W
R
E
E
F
H
L
L
-
P
K
E
G
V
R
L
D
P
S
S
L
V
Q
-
W
L
N
S
E
A
M
Q
K
H
---
V
-
R
T
L
Y
--
R
D
F
V
P
H
L
T
L
R
M
L
E
R
L
P
V
--
4
PsiBlast_PDB
69.38
32%
-126
- C3 -
2IBS
3
MTTA_THEAQ
A:
[21-210]
---------------
V
E
T
P
P
E
V
V
D
F
---
M
V
S
L
--
A
E
A
P
---
R
--
G
G
R
V
L
E
P
A
C
A
H
G
P
F
L
R
A
F
---------
R
E
A
HGTA
Y
R
F
V
G
V
E
I
D
P
K
A
L
D
L
P
P
W------------------
A
E
G
I
L
A
D
F
L
L
W
E
P
--
G
E
A
F
D
L
I
L
G
N
P
P
Y
---
G
I
V
G
E
A
S
K
-------
Y
P
--
I
H
V
F
K
A
V
K
D
L
Y
K
K
A
F
-------
S
T
W
K
G
K
Y
N
L
Y
G
A
F
L
E
K
A
V
R
L
L
K
P
G
G
V
L
V
F
V
V
P
A
T
W
L
V
L
--
E
D
F
A
L
L
R
E
F
L
A
R
E
G
K
T
S
V
Y
Y
-
L
G
E
--
V
F
P
Q
K
K
V
S
A
V
V
I
R
F
Q
K
S
G
K
G
L
S
L
W
------
D
-----
T
Q
E
S
-----------------------
E
---
S
-
G
---
F
T
P
I
L
W
--
A
E
------
Y
--------
P
H
W
E
G
E
-
I
I
R
F
E
T
E
E
T
R
K
--
L
E
I
S
G
-
M
P
--
L
G
D
--
L
F
H
-------------
I
R
F
A
A
R
S
P
-
E
F
K
K
H
P
------
A
V
R
K
E
P
G
P
--------------
G
L
--
V
P
V
L
T
G
R
------------
N
--
L
K
P
G
W
V
D
Y
--
E
K
N
H
S
G
L
W
M
P
K
E
R
A
---
K
E
---
L
R
D
F
Y
A
T
P
H
L
V
V
-
A
-
H
T
K
G
T
R
V
V
-
A
A
W
D
E
R
A
Y
P
W
R
E
E
F
H
L
L
-
P
K
E
G
V
R
L
D
P
S
S
L
V
Q
-
W
L
N
S
E
A
M
Q
K
H
---
V
-
R
T
L
Y
--
R
D
F
V
P
H
L
T
L
R
M
L
E
R
L
P
V
--
10
PsiBlast_PDB
69.36
32%
-122
- C3 -
2NP6
3
MTTA_THEAQ
A:
[20-210]
--------------
R
V
E
T
P
P
E
V
V
D
F
---
M
V
S
L
--
A
E
A
P
---
R
--
G
G
R
V
L
E
P
A
C
A
H
G
P
F
L
R
A
F
---------
R
E
A
HGTA
Y
R
F
V
G
V
E
I
D
P
K
A
L
D
L
P
P
W------------------
A
E
G
I
L
A
D
F
L
L
W
E
P
--
G
E
A
F
D
L
I
L
G
N
P
P
Y
---
G
I
V
G
E
A
S
K
-------
Y
P
--
I
H
VF
K
A
V
K
D
L
Y
K
K
A
F
-------
S
T
W
K
G
K
Y
N
L
Y
G
A
F
L
E
K
A
V
R
L
L
K
P
G
G
V
L
V
F
V
V
P
A
T
W
L
V
L
--
E
D
F
A
L
L
R
E
F
L
A
R
E
G
K
T
S
V
Y
Y
-
L
G
E
--
V
F
P
Q
K
K
V
S
A
V
V
I
R
F
Q
K
S
G
K
G
L
S
L
W
------
D
-----
T
Q
E
S
-----------------------
E
---
S
-
G
---
F
T
P
I
L
W
--
A
E
------
Y
--------
P
H
W
E
G
E
-
I
I
R
F
E
T
E
E
T
R
K
--
L
E
I
S
G
-
M
P
--
L
G
D
--
L
F
H
-------------
I
R
F
A
A
R
S
P
-
E
F
K
K
H
P
------
A
V
R
K
E
P
G
P
--------------
G
L
--
V
P
V
L
T
G
R
------------
N
--
L
K
P
G
W
V
D
Y
--
E
K
N
H
S
G
L
W
M
P
K
E
R
A
---
K
E
---
L
R
D
F
Y
A
T
P
H
L
V
V
-
A
-
H
T
K
G
T
R
V
V
-
A
A
W
D
E
R
A
Y
P
W
R
E
E
F
H
L
L
-
P
K
E
G
V
R
L
D
P
S
S
L
V
Q
-
W
L
N
S
E
A
M
Q
K
H
---
V
-
R
T
L
Y
--
R
D
F
V
P
H
L
T
L
R
M
L
E
R
L
P
V
--
25
PsiBlast_CBE
69.14
32%
-122
- C3 -
2IH2
6
MTTA_THEAQ
D:
[21-210]
---------------
V
E
T
P
P
E
V
V
D
F
---
M
V
S
L
--
A
E
AP---
R
--
G
G
R
V
L
E
P
A
C
A
H
G
P
F
L
R
A
F
---------
R
E
A
HGTAYRF
V
G
V
E
I
D
P
K
ALD
L
P
P
W------------------
A
E
G
I
L
A
D
F
L
L
W
E
P
--
G
E
A
F
D
L
I
L
G
N
P
P
Y
---
G
I
V
G
E
A
S
K
-------
Y
P
--
I
H
VFKAVKDLYKKA
F
-------
S
T
W
K
G
K
Y
N
L
Y
G
A
F
L
E
K
A
V
R
L
L
K
P
G
G
V
L
V
F
V
V
P
A
T
W
L
V
L
--
E
D
F
A
L
L
R
E
F
L
A
R
E
G
K
T
S
V
Y
Y
-
L
G
E
--
V
F
P
Q
K
K
V
S
A
V
V
I
R
F
Q
K
S
G
K
G
L
S
L
W
------
D
-----
T
Q
E
S
-----------------------
E
---
S
-
G
---
F
T
P
I
L
W
--
A
E
------
Y
--------
P
H
W
E
G
E
-
I
I
R
F
E
T
E
E
T
R
K
--
L
E
I
S
G
-
M
P
--
L
G
D
--
L
F
H
-------------
I
R
F
A
A
R
S
P
-
E
F
K
K
H
P
------
A
V
R
K
E
P
G
P
--------------
G
L
--
V
P
V
L
T
G
R
------------
N
--
L
K
P
G
W
V
D
Y
--
E
K
N
H
S
G
L
W
M
P
K
E
R
A
---
K
E
---
L
R
D
F
Y
A
T
P
H
L
V
V
-
A
-
H
T
K
G
T
R
V
V
-
A
A
W
D
E
R
A
Y
P
W
R
E
E
F
H
L
L
-
P
K
E
G
V
R
L
D
P
S
S
L
V
Q
-
W
L
N
S
E
A
M
Q
K
H
---
V
-
R
T
L
Y
--
R
D
F
V
P
H
L
T
L
R
M
L
E
R
L
P
V
--
12
PsiBlast_PDB
68.77
32%
-127
- C3 -
1G38
3
MTTA_THEAQ
A:
[1-190]
---------------
V
E
T
P
P
E
V
V
D
F
---
M
V
S
L
--
A
E
A
P
---
R
--
G
G
R
V
L
E
P
A
C
A
H
G
P
F
L
R
A
F
---------
R
E
A
HGTG
Y
R
F
V
G
V
E
I
D
P
K
A
L
D
L
P
P
W------------------
A
E
G
I
L
A
D
F
L
L
W
E
P
--
G
E
A
F
D
L
I
L
G
N
P
P
Y
---
G
I
V
G
E
A
S
K
-------
Y
P
--
I
H
VF
K
A
V
K
D
L
Y
K
K
A
F
-------
S
T
W
K
G
K
Y
N
L
Y
G
A
F
L
E
K
A
V
R
L
L
K
P
G
G
V
L
V
F
V
V
P
A
T
W
L
V
L
--
E
D
F
A
L
L
R
E
F
L
A
R
E
G
K
T
S
V
Y
Y
-
L
G
E
--
V
F
P
Q
K
K
V
S
A
V
V
I
R
F
Q
K
S
G
K
G
L
S
L
W
------
D
-----
T
Q
E
S
-----------------------
E
---
S
-
G
---
F
T
P
I
L
W
--
A
E
------
Y
--------
P
H
W
E
G
E
-
I
I
R
F
E
T
E
E
T
R
K
--
L
E
I
S
G
-
M
P
--
L
G
D
--
L
F
H
-------------
I
R
F
A
A
R
S
P
-
E
F
K
K
H
P
------
A
V
R
K
E
P
G
P
--------------
G
L
--
V
P
V
L
T
G
R
------------
N
--
L
K
P
G
W
V
D
Y
--
E
K
N
H
S
G
L
W
M
P
K
E
R
A
---
K
E
---
L
R
D
F
Y
A
T
P
H
L
V
V
-
A
-
H
T
K
G
T
R
V
V
-
A
A
W
D
E
R
A
Y
P
W
R
E
E
F
H
L
L
-
P
K
E
G
V
R
L
D
P
S
S
L
V
Q
-
W
L
N
S
E
A
M
Q
K
H
---
V
-
R
T
L
Y
--
R
D
F
V
P
H
L
T
L
R
M
L
E
R
L
P
V
--
7
PsiBlast_PDB
68.67
32%
-124
- C3 -
2IH2
5
MTTA_THEAQ
A:
[21-210]
---------------
V
E
T
P
P
E
V
V
D
F
---
M
V
S
L
--
A
E
A
P
---
R
--
G
G
R
V
L
E
P
A
C
A
H
G
P
F
L
R
A
F
---------
R
E
A
HGTA
Y
R
F
V
G
V
E
I
D
P
K
A
L
D
L
P
P
W------------------
A
E
G
I
L
A
D
F
L
L
W
E
P
--
G
E
A
F
D
L
I
L
G
N
P
P
Y
---
G
I
V
G
E
A
S
K
-------
Y
P
--
I
H
V
F
K
A
V
K
D
L
Y
K
K
A
F
-------
S
T
W
K
G
K
Y
N
L
Y
G
A
F
L
E
K
A
V
R
L
L
K
P
G
G
V
L
V
F
V
V
P
A
T
W
L
V
L
--
E
D
F
A
L
L
R
E
F
L
A
R
E
G
K
T
S
V
Y
Y
-
L
G
E
--
V
F
P
Q
K
K
V
S
A
V
V
I
R
F
Q
K
S
G
K
G
L
S
L
W
------
D
-----
T
Q
E
S
-----------------------
E
---
S
-
G
---
F
T
P
I
L
W
--
A
E
------
Y
--------
P
H
W
E
G
E
-
I
I
R
F
E
T
E
E
T
R
K
--
L
E
I
S
G
-
M
P
--
L
G
D
--
L
F
H
-------------
I
R
F
A
A
R
S
P
-
E
F
K
K
H
P
------
A
V
R
K
E
P
G
P
--------------
G
L
--
V
P
V
L
T
G
R
------------
N
--
L
K
P
G
W
V
D
Y
--
E
K
N
H
S
G
L
W
M
P
K
E
R
A
---
K
E
---
L
R
D
F
Y
A
T
P
H
L
V
V
-
A
-
H
T
K
G
T
R
V
V
-
A
A
W
D
E
R
A
Y
P
W
R
E
E
F
H
L
L
-
P
K
E
G
V
R
L
D
P
S
S
L
V
Q
-
W
L
N
S
E
A
M
Q
K
H
---
V
-
R
T
L
Y
--
R
D
F
V
P
H
L
T
L
R
M
L
E
R
L
P
V
--
5
PsiBlast_PDB
68.55
32%
-122
- C3 -
2IBT
5
MTTA_THEAQ
A:
[21-210]
---------------
V
E
T
P
P
E
V
V
D
F
---
M
V
S
L
--
A
E
A
P
---
R
--
G
G
R
V
L
E
P
A
C
A
H
G
P
F
L
R
A
F
---------
R
E
A
HGTA
Y
R
F
V
G
V
E
I
D
P
K
A
L
D
L
P
P
W------------------
A
E
G
I
L
A
D
F
L
L
W
E
P
--
G
E
A
F
D
L
I
L
G
N
P
P
Y
---
G
I
V
G
E
A
S
K
-------
Y
P
--
I
H
V
F
K
A
V
K
D
L
Y
K
K
A
F
-------
S
T
W
K
G
K
Y
N
L
Y
G
A
F
L
E
K
A
V
R
L
L
K
P
G
G
V
L
V
F
V
V
P
A
T
W
L
V
L
--
E
D
F
A
L
L
R
E
F
L
A
R
E
G
K
T
S
V
Y
Y
-
L
G
E
--
V
F
P
Q
K
K
V
S
A
V
V
I
R
F
Q
K
S
G
K
G
L
S
L
W
------
D
-----
T
Q
E
S
-----------------------
E
---
S
-
G
---
F
T
P
I
L
W
--
A
E
------
Y
--------
P
H
W
E
G
E
-
I
I
R
F
E
T
E
E
T
R
K
--
L
E
I
S
G
-
M
P
--
L
G
D
--
L
F
H
-------------
I
R
F
A
A
R
S
P
-
E
F
K
K
H
P
------
A
V
R
K
E
P
G
P
--------------
G
L
--
V
P
V
L
T
G
R
------------
N
--
L
K
P
G
W
V
D
Y
--
E
K
N
H
S
G
L
W
M
P
K
E
R
A
---
K
E
---
L
R
D
F
Y
A
T
P
H
L
V
V
-
A
-
H
T
K
G
T
R
V
V
-
A
A
W
D
E
R
A
Y
P
W
R
E
E
F
H
L
L
-
P
K
E
G
V
R
L
D
P
S
S
L
V
Q
-
W
L
N
S
E
A
M
Q
K
H
---
V
-
R
T
L
Y
--
R
D
F
V
P
H
L
T
L
R
M
L
E
R
L
P
V
--