@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_1280: (2015-12-22 )
MDHLKHLQQLQNIERIVLSGIVLANHKIEEIHSVLEPSDFYYPPHGLFFEIALKLHEVNCPIDENFIRQKMPKDKQISEDDLVAIFAASPIDNIEAYVEEIKNASIKRKLFTLANTIREQALESAQKSSDILNAVEREVYALLNGSTIEGFRGIKEVLESTMNLITENQRKGSLKVTGIPTGFVQLDNYTSGFNQGSLVILGARPSMGKTSLMMNMVLSALNDDRGVAVFSLEMSAEQLALRALSDLTSINMHDLESARLDDDQWENLAKCFDHLSQKKLFFYDKSYVRMDQIRLQLRKLKSQHKELGIAFIDYLQLMSGNKATKERHEQIAEISRELKTLARELEIPIIALVQLNRSLENRDDKRPILSDIKDSGGIEQDADIVLFLYRGYIYQMRAEDNKIDKLKKEGKVEEAQELHLKVNEERRIHKQNGSIEEAEIIVAKNRNGATGTVYTRFNAPFTRYEDMPVDSHLEEGQETKFEMPTT
Atome Classification :
(20 SA)
.........10........20........30....-....40........50.....-...60........70...---.....80----.....-----.-----..--90..-......100.......110.......120.......130.......140.......150.......160-.....-..170.......180.......190.......200.......210......-.-220.-..-.....230.......240.......250.......260.......270.......280.......290.......300.......310.......320.....-...330.......340.......350.......360.......370.......380.......390.......400....----...410.......420----........430.......440.......450.......460.......470.......480....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
D
H
L
K
H
L
Q
Q
L
Q
N
I
E
R
I
V
L
S
G
I
V
LAN
H
K
I
E
E
I
H
S
VL-EPSDFYYPPH
G
L
F
F
E
I
A
L
K
LH-EVNCPI
D
E
N
F
I
R
Q
KMPKD---KQISED
D
----
L
V
A
I
F
-----A-----AS--PI
D
N
-
I
E
A
Y
V
E
E
I
KN
A
S
I
K
R
K
L
F
T
L
A
N
T
I
R
E
Q
A
L
E
S
A
Q
K
S
S
D
I
L
N
A
V
E
R
E
V
Y
A
L
LNGST
I
E
G
F
R
G
I
K
E
V
L
E
S
T
M
-
N
L
I
T
E-NQRKG
S
L
K
V
TGIP
T
G
F
V
Q
LDNYTSGFNQG
S
L
V
I
L
GARPSM
G
K
T
S
L
M
M
N
M
V
L
-
S
-
A
L-N-DD-R
G
V
A
V
F
S
L
EM
S
A
E
Q
L
A
L
R
A
L
S
D
L
TSI
N
M
H
D
L
E
SARL
D
D
D
Q
W
E
N
L
A
K
C
F
D
H
LSQK
K
L
F
F
YDK
S
Y
V
R
M
D
Q
I
R
L
Q
L
R
K
L
K
S
Q
H
K
E
L
G
I
A
F
I
D
Y
L
Q
L
MSG-NK
A
T
K
E
-
R
H
E
Q
I
A
E
I
S
R
E
L
K
T
L
A
R
ELEI
P
I
I
A
L
V
Q
L
N
R
S
LENRDDKR
P
I
L
S
D
I
KDSGGIEQDA
D
I
V
L
F
L
YR
G
Y
I
Y
Q
MRAED
N
K
I
D
K
L
----
K
KEGK
V
E
E
A
Q
E
L
H
L
K
-----VN
E
E
R
R
I
HKQNGSI
E
E
A
E
I
I
V
A
KNRNGA
T
G
T
V
Y
T
R
FNAPFTRYEDMPV
D
S
H
L
EEGQETKFEMPTT
1
PsiBlast_PDB
90.97
94%
-101
- C3 -
4A1F
2
?
A:
[2-323]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
I
K
E
V
L
E
S
A
M
-
D
L
I
T
E
-
N
Q
R
K
G
S
L
E
V
T
G
I
P
T
G
F
V
Q
L
D
N
Y
T
S
G
F
N
K
G
S
L
V
I
I
G
A
R
P
S
M
G
K
T
S
L
M
M
N
M
V
L
-
S
-
A
L
-
N
-
D
D
-
R
G
V
A
V
F
S
L
E
M
S
A
E
Q
L
A
L
R
A
L
S
D
L
T
S
I
N
M
H
D
L
E
S
G
R
L
D
D
D
Q
W
E
N
L
A
K
C
F
D
H
L
S
Q
K
K
L
F
F
Y
D
K
S
Y
V
R
I
E
Q
I
R
L
Q
L
R
K
L
K
S
Q
H
K
E
L
G
I
A
F
I
D
Y
L
Q
L
M
S
G
-
S
K
A
T
K
E
-
R
H
E
Q
I
A
E
I
S
R
E
L
K
T
L
A
R
E
L
E
I
P
I
I
A
L
V
Q
L
N
R
S
L
E
N
R
D
D
K
R
P
I
L
S
D
I
K
D
S
G
G
I
E
Q
D
A
D
I
V
L
F
L
Y
R
G
Y
I
Y
Q
M
R
A
E
D
N
K
I
D
K
L
----
K
K
E
G
K
I
E
E
A
Q
E
L
Y
L
K
-----
V
N
E
E
R
R
I
H
K
Q
N
G
S
I
E
E
A
E
I
I
V
A
K
N
R
N
G
A
T
G
T
V
Y
T
R
F
N
A
P
F
T
R
Y
E
D
M
P
I
D
S
H
L
-------------
39
HHSearch
81.49
35%
-106
- C3 -
2R6A
2
?
A:
[8-441]
----
R
I
P
P
Q
S
I
E
A
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
V
A
-
D
R
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
---
E
Q
L
E
E
I
G
----
G
V
S
Y
L
-----
S
E
L
A
D
A
V
P
--
T
A
A
N
-
V
E
Y
Y
A
R
I
V
E
E
K
S
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
T
R
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
V
S
Q
R
K
H
S
G
A
F
K
N
I
K
D
I
L
V
Q
T
Y
-
D
N
I
E
M
-
L
H
-
N
R
D
G
E
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
-
N
-
V
A
-
T
K
T
N
-
E
N
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
Q
E
S
-
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
G
-
S
G
R
----
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
---
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
--------------------------------------------------
K
N
I
I
E
I
I
I
A
K
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
E
Y
N
K
F
V
N
L
-------------------
9
PsiBlast_PDB
80.59
31%
-102
- C3 -
4NMN
3
?
A:
[5-432]
----------
E
S
A
E
R
A
V
L
G
S
M
L
E
D
P
E
N
I
P
L
V
L
E
Y
L
-
K
E
E
D
F
C
I
D
E
H
K
L
L
F
R
V
L
T
N
L
W
S
E
Y
G
N
K
L
D
F
V
L
I
K
D
H
L
E
K
K
NLL
Q
---
I
D
W
----
L
E
E
L
Y
E
E
---
A
-----
V
S
--
P
-
D
T
-
L
E
E
V
C
K
I
V
K
Q
R
S
A
Q
R
A
I
I
Q
L
G
I
E
L
I
H
K
G
K
E
N
K
D
F
H
T
L
I
E
E
A
Q
S
R
-
I
F
S
I
A
E
S
--
S
T
Q
F
Y
H
V
K
D
V
A
E
E
V
I
-
E
L
I
Y
K
-
F
K
S
S
D
R
L
-
V
T
G
L
P
S
G
F
T
E
L
D
L
K
T
T
G
F
H
P
G
D
L
I
I
L
A
A
R
P
G
M
G
K
T
A
F
M
L
S
I
I
Y
-
N
-
L
A
-
K
-
D
E
G
K
P
S
A
V
F
S
L
E
M
S
K
E
Q
L
V
M
R
L
L
S
M
M
S
E
V
P
L
F
K
I
R
S
G
S
I
S
N
E
D
L
K
K
L
E
A
S
A
I
E
L
A
K
Y
D
I
Y
L
D
D
T
P
A
L
T
T
T
D
L
R
I
R
A
R
K
L
R
K
E
-
K
E
V
E
F
V
A
V
D
Y
L
Q
L
L
R
P
-
P
V
R
K
S
P
-
R
Q
E
E
V
A
E
V
S
R
N
L
K
A
L
A
K
E
L
R
I
P
V
M
A
L
A
Q
L
S
R
E
V
E
K
R
S
D
K
R
P
Q
L
A
D
L
R
E
S
G
Q
I
E
Q
D
A
D
L
I
L
F
L
H
R
P
E
Y
Y
T
K
K
P
N
----------------------------------
E
Q
G
I
---------
A
E
V
I
I
A
K
Q
R
Q
G
P
T
D
I
V
K
L
A
F
I
K
E
Y
T
K
F
A
N
L
E
------------------
35
PsiBlast_CBE
79.88
33%
-109
- C3 -
2Q6T
1
?
B:
[13-440]
-------------
E
Q
S
V
L
G
S
I
L
L
D
S
D
V
M
D
E
V
E
G
L
L
P
S
P
E
A
F
Y
A
E
A
H
R
K
I
Y
A
A
M
Q
A
L
R
-
S
Q
G
R
P
V
D
L
V
T
L
S
E
E
L
S
R
R
---
G
Q
L
E
E
V
G
GT
A
Y
L
L
Q
L
S
-----
E
-----
A
T
--
P
T
A
A
Y
A
E
H
Y
A
R
I
V
A
E
K
W
T
L
R
R
L
I
Q
A
A
G
E
A
M
R
L
A
Y
E
E
A
G
S
L
D
E
I
L
D
T
A
G
K
K
I
L
E
V
A
L
------
A
R
P
M
R
E
L
V
H
E
T
F
-
E
H
I
E
A
L-----------
V
R
T
G
F
K
E
L
D
Q
L
I
G
T
L
G
P
G
S
L
N
I
I
A
A
R
P
A
M
G
K
T
A
F
A
L
T
I
A
Q
N
A
-
A
L
-
K
-
E
G
-
V
G
V
G
I
Y
S
L
E
M
P
A
A
Q
L
T
L
R
M
M
C
S
E
A
R
I
D
M
N
R
V
R
L
---
T
D
R
D
F
S
R
L
V
D
V
A
S
R
L
S
E
A
P
I
Y
I
D
D
T
P
D
L
T
L
M
E
V
R
A
R
A
R
R
L
V
S
Q
N
-
Q
V
G
L
I
I
I
D
Y
L
Q
L
M
S
G
P-----
N
-
R
Q
Q
E
I
A
A
I
S
R
G
L
K
A
L
A
R
E
L
G
I
P
I
I
A
L
S
Q
L
S
R
A
V
E
A
R
P
N
K
R
P
M
L
S
D
L
R
E
S
G
S
I
E
Q
D
A
D
L
V
M
F
I
Y
R
D
E
Y
Y
N
P
H
S
E
K
A
G
I
-------------------------------------------
A
E
I
I
V
G
K
Q
R
N
G
P
T
G
T
V
E
L
Q
F
H
A
S
H
V
R
F
N
D
L
-------------------
61
Fugue
79.57
33%
-102
- C3 -
2Q6T
1
?
A:
[5-440]
-----
I
P
P
H
S
L
E
A
E
Q
S
V
L
G
S
I
L
L
D
S
D
V
M
D
E
V
E
G
L
L
P
S
P
E
A
F
Y
A
E
A
H
R
K
I
Y
A
A
M
Q
A
L
R
-
S
Q
G
R
P
V
D
L
V
T
L
S
E
E
L
S
R
R
GQL
E
E
V
G
G
T
A
----
Y
L
L
Q
L
-----
S
-----
E
A
TP
T
A
A
Y
-
A
E
H
Y
A
R
I
V
A
E
K
W
T
L
R
R
L
I
Q
A
A
G
E
A
M
R
L
A
Y
E
E
A
G
S
L
D
E
I
L
D
T
A
G
K
K
I
L
E
V
A
L
T
K
T
D
T
E
A
R
P
M
R
E
L
V
H
E
T
F
-
E
H
I
E
------------
A
V
R
T
G
F
K
E
L
D
Q
L
I
G
T
L
G
P
G
S
L
N
I
I
A
A
R
P
A
M
G
K
T
A
F
A
L
T
I
A
Q
-
N
-
A
A
L
K
-
E
G
-
V
G
V
G
I
Y
S
L
E
M
P
A
A
Q
L
T
L
R
M
M
C
S
E
A
R
I
D
M
N
R
V
R
L
G
Q
L
T
D
R
D
F
S
R
L
V
D
V
A
S
R
L
S
E
A
P
I
Y
I
D
D
T
P
D
L
T
L
M
E
V
R
A
R
A
R
R
L
V
S
Q
N
-
Q
V
G
L
I
I
I
D
Y
L
Q
L
M
S
G
-
P
----
N
-
R
Q
Q
E
I
A
A
I
S
R
G
L
K
A
L
A
R
E
L
G
I
P
I
I
A
L
S
Q
L
S
R
A
V
E
A
R
P
N
K
R
P
M
L
S
D
L
R
E
S
G
S
I
E
Q
D
A
D
L
V
M
F
I
Y
R
D
E
Y
Y
-------------------------------------------
N
P
H
S
E
K
A
G
I
A
E
I
I
V
G
K
Q
R
N
G
P
T
G
T
V
E
L
Q
F
H
A
S
H
V
R
F
N
D
L
-------------------
3
PsiBlast_PDB
79.45
36%
-102
- C3 -
2R6E
1
?
A:
[17-441]
-------------
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
V
A
-
D
R
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
---
E
Q
L
E
E
I
G
----
G
V
S
Y
L
S
E
L
A
D
A
-----
V
P
--
T
A
A
N
-
V
E
Y
Y
A
R
I
V
E
E
K
S
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
T
R
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
V
S
------------------------------------
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
-
N
V
A
T
-
K
-
T
N
-
E
N
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
-
Q
E
S
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
G
-
S
G
R
----
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
---
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
-------
K
N
I
I
E
I
I
IAK
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
EYN
K
F
V
N
L
--------------------------------------------------------------
30
PsiBlast_CBE
79.41
36%
-102
- C3 -
2R6E
1
?
B:
[17-441]
-------------
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
V
A
-
D
R
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
---
E
Q
L
E
E
I
G
----
G
V
S
Y
L
SELAD
A
-----
V
P
--
T
A
A
N
-
V
E
Y
Y
A
R
I
V
E
E
K
S
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
T
R
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
V
S
------------------------------------
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
-
N
V
A
T
-
K
-
T
N
-
E
N
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
-
Q
E
S
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
G
-
S
G
R
----
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
---
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
-------
K
N
I
I
E
I
IIAK
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
EYNKF
V
N
L
--------------------------------------------------------------
24
PsiBlast_CBE
77.40
36%
-91
- C3 -
4ESV
2
?
H:
[17-444]
-------------
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
V
A
-
D
R
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
---
E
Q
L
E
E
I
G
----
G
V
S
Y
L
S
E
L
A
D
A
-----
V
P
--
T
A
A
N
-
V
E
Y
Y
A
R
I
V
E
E
K
S
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
T
R
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
---------
F
K
N
I
K
D
I
L
V
Q
T
Y
D
N
I
E
M
L
-
H
N
R
-----
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
-
N
V
A
T
-
K
-
T
N
-
E
N
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
-
Q
E
S
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
G
-
S
G
R
S
K
E
N
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
Q
D
K
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
Y
N
K
D
S
E
N
K
N
I
I
E
I
IIAK
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
E
Y
N
K
F
V
N
L
E
R
R
F
----------------------------------------------------------
29
PsiBlast_CBE
77.32
36%
-93
- C3 -
4ESV
3
?
B:
[17-444]
-------------
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
V
A
-
D
R
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
---
E
Q
L
E
E
I
G
----
G
V
S
Y
L
S
E
L
A
D
A
-----
V
P
--
T
A
A
N
-
V
E
Y
Y
A
R
I
V
E
E
K
S
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
T
R
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
V
S
Q
R
K
H
S
G
A
F
K
N
I
K
D
I
L
V
Q
T
Y
D
N
I
E
M
L
-
H
N
--
G
--
E
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
-
N
V
A
T
-
K
-
T
N
-
E
N
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
-
Q
E
S
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
G
-
S
G
R
S
K
E
N
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
--------
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
Y
N
K
D
S
E
N
K
N
I
I
E
I
IIAK
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
EYN
K
F
V
N
L
E
R
R
F
----------------------------------------------------------
33
PsiBlast_CBE
77.30
33%
-108
- C3 -
2Q6T
1
?
D:
[13-440]
-------------
E
Q
S
V
L
G
S
I
L
L
D
S
D
V
M
D
E
V
E
G
L
L
P
S
P
E
A
F
Y
A
E
A
H
R
K
I
Y
A
A
M
Q
A
L
R
-
S
Q
G
R
P
V
D
L
V
T
L
S
E
E
L
S
R
R
---
G
Q
L
E
E
V
G
G
T
A
Y
L
L
Q
L
S
-----
E
-----
A
T
--
P
T
A
A
Y
A
E
H
Y
A
R
I
V
A
E
K
W
T
L
R
R
L
I
Q
A
A
G
E
A
M
R
L
A
Y
E
E
A
G
S
L
D
E
I
L
D
T
A
G
K
K
I
L
E
V
A
L
T
K
--
T
E
A
R
P
M
R
E
L
V
H
E
T
F
-
E
H
I
E
A
L
F
------------
T
G
F
K
E
L
D
Q
L
I
G
T
L
G
P
G
S
L
N
I
I
A
A
R
P
A
M
G
K
T
A
F
A
L
T
I
A
Q
N
A
-
A
L
-
K
-
E
G
-
V
G
V
G
I
Y
S
L
E
M
P
A
A
Q
L
T
L
R
M
M
C
S
E
A
R
---------------
F
S
R
L
V
D
V
A
S
R
L
S
E
A
P
I
Y
I
D
D
T
P
D
L
T
L
M
E
V
R
A
R
A
R
R
L
V
S
Q
N
-
Q
V
G
L
I
I
I
D
Y
L
Q
L
M
S
G
------
N
-
R
Q
Q
E
I
A
A
I
S
R
G
L
K
A
L
A
R
E
L
G
I
P
I
I
A
L
S
Q
L
S
R
A
V
E
A
R
P
N
K
R
P
M
L
S
D
L
R
E
S
G
S
I
E
Q
D
A
D
L
V
M
F
I
Y
R
D
E
Y
Y
N
P
H
S
E
K
A
G
I
-------------------------------------------
A
E
I
I
V
G
K
Q
R
N
G
P
T
G
T
V
E
L
Q
F
H
A
S
H
V
R
F
N
D
L
-------------------
2
PsiBlast_PDB
77.24
36%
-97
- C3 -
2R6A
2
?
A:
[17-441]
-------------
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
V
A
-
D
R
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
---
E
Q
L
E
E
I
G
----
G
V
S
Y
L
S
E
L
A
D
A
-----
V
P
--
T
A
A
N
-
V
E
Y
Y
A
R
I
V
E
E
K
S
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
T
R
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
V
S
Q
R
K
H
S
G
A
F
K
N
I
K
D
I
L
V
Q
T
Y
D
N
I
E
M
L
-
H
N
R
D
G
--
E
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
-
N
V
A
T
-
K
-
T
N
-
E
N
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
-
Q
E
S
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
G
-
S
G
R
----
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
---
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
-------
K
N
I
I
E
I
I
IAK
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
EYN
K
F
V
N
L
--------------------------------------------------------------
26
PsiBlast_CBE
77.21
36%
-94
- C3 -
4ESV
4
?
F:
[17-441]
-------------
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
V
A
-
D
R
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
---
E
Q
L
E
E
I
G
----
G
V
S
Y
L
S
E
L
A
D
A
-----
V
P
--
T
A
A
N
-
V
E
Y
Y
A
R
I
V
E
E
K
S
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
T
R
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
V
S
------
A
F
K
N
I
K
D
I
L
V
Q
T
Y
D
N
I
E
M
L
---------
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
-
N
V
A
T
-
K
-
T
N
-
E
N
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
-
Q
E
S
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
G
-
S
G
R
S
K
E
N
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
Q
D
K
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
Y
N
K
D
S
E
N
K
N
I
I
E
I
IIAK
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
EYN
K
F
V
N
L
--------------------------------------------------------------
28
PsiBlast_CBE
77.01
36%
-91
- C3 -
4ESV
4
?
C:
[17-441]
-------------
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
V
A
-
D
R
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
---
E
Q
L
E
E
I
G
----
G
V
S
Y
L
S
E
L
A
D
A
-----
V
P
--
T
A
A
N
-
V
E
Y
Y
A
R
I
V
E
E
K
S
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
T
R
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
V
S
Q
R
K
H
S
G
A
F
K
N
I
K
D
I
L
V
Q
T
Y
D
N
I
E
M
L
-
H
N
R
D
G
--
E
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
-
N
V
A
T
-
K
-
T
N
-
E
N
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
-
Q
E
S
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
G
-
S
G
R
S
K
E
N
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
Q
D
K
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
Y
N
K
D
S
E
N
K
N
I
I
E
I
IIAK
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
EYN
K
F
V
N
L
--------------------------------------------------------------
8
PsiBlast_PDB
76.82
33%
-101
- C3 -
2Q6T
1
?
A:
[13-440]
-------------
E
Q
S
V
L
G
S
I
L
L
D
S
D
V
M
D
E
V
E
G
L
L
P
S
P
E
A
F
Y
A
E
A
H
R
K
I
Y
A
A
M
Q
A
L
R
-
S
Q
G
R
P
V
D
L
V
T
L
S
E
E
L
S
R
R
---
G
Q
L
E
E
V
G
G
T
A
Y
L
L
Q
L
S
-----
E
-----
A
T
--
P
T
A
A
Y
A
E
H
Y
A
R
I
V
A
E
K
W
T
L
R
R
L
I
Q
A
A
G
E
A
M
R
L
A
Y
E
E
A
G
S
L
D
E
I
L
D
T
A
G
K
K
I
L
E
V
A
L
T
K
T
D
T
E
A
R
P
M
R
E
L
V
H
E
T
F
-
E
H
I
E
A
------------
V
R
T
G
F
K
E
L
D
Q
L
I
G
T
L
G
P
G
S
L
N
I
I
A
A
R
P
A
M
G
K
T
A
F
A
L
T
I
A
Q
N
A
-
A
L
-
K
-
E
G
-
V
G
V
G
I
Y
S
L
E
M
P
A
A
Q
L
T
L
R
M
M
C
S
E
A
R
I
D
M
N
R
V
R
L
G
Q
L
T
D
R
D
F
S
R
L
V
D
V
A
S
R
L
S
E
A
P
I
Y
I
D
D
T
P
D
L
T
L
M
E
V
R
A
R
A
R
R
L
V
S
Q
N
-
Q
V
G
L
I
I
I
D
Y
L
Q
L
M
S
G
P-----
N
-
R
Q
Q
E
I
A
A
I
S
R
G
L
K
A
L
A
R
E
L
G
I
P
I
I
A
L
S
Q
L
S
R
A
V
E
A
R
P
N
K
R
P
M
L
S
D
L
R
E
S
G
S
I
E
Q
D
A
D
L
V
M
F
I
Y
R
D
E
Y
Y
N
P
H
S
E
K
A
G
I
-------------------------------------------
A
E
I
I
V
G
K
Q
R
N
G
P
T
G
T
V
E
L
Q
F
H
A
S
H
V
R
F
N
D
L
-------------------
34
PsiBlast_CBE
76.79
33%
-108
- C3 -
2Q6T
1
?
C:
[13-440]
-------------
E
Q
S
V
L
G
S
I
L
L
D
S
D
V
M
D
E
V
E
G
L
L
P
S
P
E
A
F
Y
A
E
A
H
R
K
I
Y
A
A
M
Q
A
L
R
-
S
Q
G
R
P
V
D
L
V
T
L
S
E
E
L
S
R
R
---
G
Q
L
E
E
V
G
G
T
A
Y
L
L
Q
L
S
-----
E
-----
A
T
--
P
T
A
A
Y
A
E
H
Y
A
R
I
V
A
E
K
W
T
L
R
R
L
I
Q
A
A
G
E
A
M
R
L
A
Y
E
E
A
G
S
L
D
E
I
L
D
T
A
G
K
K
I
L
E
V
A
L
T
K
T
D
T
E
A
R
P
M
R
E
L
V
H
E
T
F
-
E
H
I
----------------
T
G
F
K
E
L
D
Q
L
I
G
T
L
G
P
G
S
L
N
I
I
A
A
R
P
A
M
G
K
T
A
F
A
L
T
I
A
Q
N
A
-
A
L
-
K
-
E
G
-
V
G
V
G
I
Y
S
L
E
M
P
A
A
Q
L
T
L
R
M
M
C
S
E
A
R
I
D
M
N
----------
D
F
S
R
L
V
D
V
A
S
R
L
S
E
A
P
I
Y
I
D
D
T
P
D
L
T
L
M
E
V
R
A
R
A
R
R
L
V
S
Q
N
-
Q
V
G
L
I
I
I
D
Y
L
Q
L
M
S
G
P-----
N
-
R
Q
Q
E
I
A
A
I
S
R
G
L
K
A
L
A
R
E
L
G
I
P
I
I
A
L
S
Q
L
S
R
A
V
E
A
R
P
N
K
R
P
M
L
S
D
L
R
E
S
G
S
I
E
Q
D
A
D
L
V
M
F
I
Y
R
D
E
Y
Y
N
P
H
S
E
K
A
G
I
-------------------------------------------
A
E
I
I
V
G
K
Q
R
N
G
P
T
G
T
V
E
L
Q
F
H
A
S
H
V
R
F
N
D
L
-------------------
27
PsiBlast_CBE
76.66
36%
-91
- C3 -
4ESV
1
?
D:
[17-441]
-------------
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
V
A
-
D
R
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
---
E
Q
L
E
E
I
G
----
G
V
S
Y
L
S
E
L
A
D
A
-----
V
P
--
T
A
A
N
-
V
E
Y
Y
A
R
I
V
E
E
K
S
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
T
R
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
V
S
Q
R
K
H
--
A
F
K
N
I
K
D
I
L
V
Q
T
Y
D
N
I
E
M
L
-
H
N
R
D
G
---
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
-
N
V
A
T
-
K
-
T
N
-
E
N
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
-
Q
E
S
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
G
-
S
G
R
S
K
E
N
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
Q
D
K
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
Y
N
K
D
S
E
N
K
N
I
I
E
I
IIAK
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
EYN
K
F
V
N
L
--------------------------------------------------------------
23
PsiBlast_CBE
76.62
36%
-91
- C3 -
4ESV
27
?
I:
[17-441]
-------------
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
V
A
-
D
R
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
---
E
Q
L
E
E
I
G
----
G
V
S
Y
L
S
E
L
A
D
A
-----
V
P
--
T
A
A
N
-
V
E
Y
Y
A
R
I
V
E
E
K
S
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
T
R
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
---------
F
K
N
I
K
D
I
L
V
Q
T
Y
D
N
I
E
M
L
---------
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
-
N
V
A
T
-
K
-
T
N
-
E
N
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
-
Q
E
S
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
G
-
S
G
R
S
K
E
N
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
Q
D
K
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
Y
N
K
D
S
E
N
K
N
I
I
E
I
IIAK
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
E
YNKF
V
N
L
--------------------------------------------------------------
31
PsiBlast_CBE
76.50
36%
-110
- C3 -
2R6A
2
?
B:
[17-441]
-------------
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
V
A
-
D
R
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
---
E
Q
L
E
E
I
G
----
G
V
S
Y
L
S
E
L
A
D
A
-----
V
P
--
T
A
A
N
-
V
E
Y
Y
A
R
I
V
E
E
K
S
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
T
R
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
V
S
Q
R
K
H
S
G
A
F
K
N
I
K
D
I
L
V
Q
T
Y
D
N
I
E
-----------
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
-
N
V
A
T
-
K
-
T
N
-
E
N
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
-
Q
E
S
G
L
G
M
I
V
I
D
Y
L
Q
L
I
-------------
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
-------------------------
D
A
D
I
V
A
F
L
--------------
I
I
E
I
I
I
AK
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
EYN
K
F
V
N
L
--------------------------------------------------------------
36
PsiBlast_CBE
76.36
31%
-102
- C3 -
4NMN
3
?
B:
[5-432]
----------
E
S
A
E
R
A
V
L
G
S
M
L
E
D
P
E
N
I
P
L
V
L
E
Y
L
-
K
E
E
D
F
C
I
D
E
H
K
L
L
F
R
V
L
T
N
L
W
S
E
-
G
N
K
L
D
F
V
L
I
K
D
H
L
E
K
K
------
P
I
D
W
----
L
E
E
L
Y
E
E
---
A
-----
V
S
--
P
-
D
T
-
L
E
E
V
C
K
I
V
K
Q
R
S
A
Q
R
A
I
I
Q
L
G
I
E
L
I
H
K
G
K
E
N
K
D
F
H
T
L
I
E
E
A
Q
S
R
-
I
F
S
I
A
E
S
A
T
S
T
Q
F
Y
H
V
K
D
V
A
E
E
V
I
-
E
L
I
Y
K
-
F
K
S
S
D
R
L
-
V
T
G
L
P
S
G
F
T
E
L
D
L
K
T
T
G
F
H
P
G
D
L
I
I
L
A
A
R
P
G
M
G
K
T
A
F
M
L
S
I
I
Y
-
N
-
L
A
-
K
-
D
E
G
K
P
S
A
V
F
S
L
E
M
S
K
E
Q
L
V
M
R
L
L
S
M
M
S
E
V
P
L
F
K
I
R
S
G
S
I
S
N
E
D
L
K
K
L
E
A
S
A
I
E
L
A
K
Y
D
I
Y
L
D
D
T
P
A
L
T
T
T
D
L
R
I
R
A
R
K
L
R
K
E
-
K
E
V
E
F
V
A
V
D
Y
L
Q
L
L
R
P
-
P
V
R
K
S
P
-
R
Q
E
E
V
A
E
V
S
R
N
L
K
A
L
A
K
E
L
R
I
P
V
M
A
L
A
Q
L
S
--------
K
R
P
Q
L
A
D
L
R
E
S
G
Q
I
E
Q
D
A
D
L
I
L
F
L
H
R
P
E
Y
Y
T
------------------------------------
P
E
E
Q
G
I
---------
A
E
V
I
I
A
K
Q
R
Q
G
P
T
D
I
V
K
L
A
F
I
K
E
Y
T
K
F
A
N
L
-------------------
25
PsiBlast_CBE
76.13
36%
-89
- C3 -
4ESV
1
?
G:
[17-441]
-------------
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
V
A
-
D
R
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
---
E
Q
L
E
E
I
G
----
G
V
S
Y
L
S
E
L
A
D
A
-----
V
P
--
T
A
A
N
-
V
E
Y
Y
A
R
I
V
E
E
K
S
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
T
R
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
V
S
-------
F
K
N
I
K
D
I
L
V
Q
T
Y
D
N
I
E
M
L
---------
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
-
N
V
A
T
-
K
-
T
N
-
E
N
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
-
Q
E
S
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
G
-
S
G
R
S
K
E
N
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
Q
D
K
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
Y
N
K
D
S
E
N
K
N
I
I
E
I
IIAK
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
EYN
K
F
V
N
L
--------------------------------------------------------------