@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0848: (2016-03-19 )
MTKLKVTGLKKSFGANEVLKGIDIEVKEGEVVCVIGPSGSGKSTFLRCMNNLEEITAGEVVVDDFNITDKKVDINKVRENIGMVFQHFNLFPHLSVLENITLAPVELKKMDKEAAKSNALRLLEQVGLREKAEEFPNQLSGGQKQRVAIARALAMDPDIMLFDEPTSALDPEMVGEVLGVMKELAKGGMTMMIVTHEMGFAREVGDRVIFMDGGYIVEEGKPADIFDNPTNERTISFLDKVL
Atome Classification :
(31 SA)
.........10......---..20........30........40........50.----.......60...-------------.....70........80......--..90........100..--....-.-110.......120....--..-.130...--....140.......150...-....160.......170......-.180...-....190.......200.......210........220.......230........240----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MT
K
L
K
V
TGLKKSF
G
A
N
E
---
V
LKG
I
D
I
E
V
KEG
E
V
V
C
V
IGPSGS
G
K
S
T
F
L
R
C
M
N
N
L
----
E
E
ITAG
E
V
V
V
DD-------------FNITDKKV
D
I
N
K
V
R
E
N
I
G
M
V
F
Q
H
--FNLFP
H
L
S
V
L
E
NITLA
P
--
V
E
L
K
-
K
-
M
D
K
E
A
A
K
S
N
A
L
R
L
L
E
Q
V--G
L
-
R
E
K
A
E
E
F
--
P
N
Q
LSGG
Q
K
Q
R
V
A
I
A
R
A
LAM-DP
D
I
M
L
FDEPTSAL
D
P
E
M
V
G
E
V
L
-
G
V
M
K
E
L
A-KG
G
M
T
M
M
I
V
THEMGF
A
R
E
VG
D
R
V
I
F
M-DG
G
Y
I
V
EEGKPADIFDNPT-N
E
R
T
I
S
F
L
D
K
VL----
4
PsiBlast_PDB
97.62
67%
-120
- C1 -
2OUK
1
?
A:
[25-263]
---
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
---
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
----
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
--
M
K
V
R
-
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
--
G
L
-
K
D
K
A
H
A
Y
--
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
-
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
-
H
E
R
T
K
A
F
L
S
K
V
F
----
27
PsiBlast_CBE
96.95
67%
-120
- C1 -
2OLK
1
?
D:
[25-263]
---
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
---
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
----
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
--
M
K
V
R
-
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
--
G
L
-
K
D
K
A
H
A
Y
--
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
-
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
-
H
E
R
T
K
A
F
L
S
K
V
F
----
29
PsiBlast_CBE
95.85
67%
-120
- C1 -
2OLK
2
?
B:
[25-263]
---
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
---
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
----
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
--
M
K
V
R
-
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
--
G
L
-
K
D
K
A
H
A
Y
--
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
-
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
-
H
E
R
T
K
A
F
L
S
K
V
F
----
122
HHSearch
95.74
67%
-117
- C1 -
2OLJ
4
?
A:
[22-262]
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
---
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
----
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
--
M
K
V
R
-
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
--
G
L
-
K
D
K
A
H
A
Y
--
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
-
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
-
H
E
R
T
K
A
F
L
S
K
V
-----
2
PsiBlast_PDB
95.41
67%
-122
- C1 -
2OLJ
4
?
A:
[25-263]
---
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
---
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
----
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
--
M
K
V
R
-
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
--
G
L
-
K
D
K
A
H
A
Y
--
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
-
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
-
H
E
R
T
K
A
F
L
S
K
V
F
----
5
PsiBlast_PDB
94.46
67%
-118
- C1 -
2Q0H
4
?
A:
[25-263]
---
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
---
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
----
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
--
M
K
V
R
-
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
--
G
L
-
K
D
K
A
H
A
Y
--
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
-
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
-
H
E
R
T
K
A
F
L
S
K
V
F
----
1
PsiBlast_PDB
93.51
67%
-113
- C1 -
3C41
3
?
J:
[4-242]
---
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
---
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
----
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
--
M
K
V
R
-
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
--
G
L
-
K
D
K
A
H
A
Y
--
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
-
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
-
H
E
R
T
K
A
F
L
S
K
V
F
----
23
PsiBlast_CBE
93.41
67%
-122
- C1 -
2Q0H
4
?
B:
[25-263]
---
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
---
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
----
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
--
M
K
V
R
-
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
--
G
L
-
K
D
K
A
H
A
Y
--
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
-
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
-
H
E
R
T
K
A
F
L
S
K
V
F
----
6
PsiBlast_PDB
93.36
67%
-115
- C1 -
3C4J
3
?
A:
[25-263]
---
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
---
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
----
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
--
M
K
V
R
-
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
--
G
L
-
K
D
K
A
H
A
Y
--
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
-
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
-
H
E
R
T
K
A
F
L
S
K
V
F
----
33
PsiBlast_CBE
93.24
61%
-113
- C1 -
4U02
1
?
D:
[5-242]
---
I
R
I
R
N
L
H
K
W
F
G
P
L
H
---
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
----
E
D
F
Q
E
G
E
V
V
V
D
G
-------------
L
S
V
K
D
D
R
A
-
L
R
E
I
R
R
E
V
G
M
V
F
Q
Q
--
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
--
M
R
V
R
-
R
-
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
--
G
I
-
L
D
Q
A
R
K
Y
--
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
-
D
V
M
R
D
L
A
-
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
-
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
-
E
E
R
T
R
S
F
L
Q
R
V
L
----
22
PsiBlast_CBE
93.01
67%
-120
- C1 -
3C4J
4
?
B:
[25-263]
---
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
---
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
----
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
--
M
K
V
R
-
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
--
G
L
-
K
D
K
A
H
A
Y
--
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
-
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
-
H
E
R
T
K
A
F
L
S
K
V
F
----
25
PsiBlast_CBE
92.93
67%
-118
- C1 -
2OUK
1
?
C:
[25-263]
---
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
---
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
----
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
--
M
K
V
R
-
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
--
G
L
-
K
D
K
A
H
A
Y
--
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
-
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
-
H
E
R
T
K
A
F
L
S
K
V
F
----
24
PsiBlast_CBE
92.92
67%
-116
- C1 -
2OUK
2
?
D:
[25-263]
---
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
---
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
----
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
--
M
K
V
R
-
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
--
G
L
-
K
D
K
A
H
A
Y
--
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
-
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
-
H
E
R
T
K
A
F
L
S
K
V
F
----
28
PsiBlast_CBE
92.91
67%
-119
- C1 -
2OLK
1
?
C:
[25-263]
---
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
---
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
----
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
--
M
K
V
R
-
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
--
G
L
-
K
D
K
A
H
A
Y
--
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
-
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
-
H
E
R
T
K
A
F
L
S
K
V
F
----
35
PsiBlast_CBE
92.79
61%
-117
- C1 -
4U02
1
?
B:
[5-242]
---
I
R
I
R
N
L
H
K
W
F
G
P
L
H
---
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
----
E
D
F
Q
E
G
E
V
V
V
D
G
-------------
L
S
V
K
D
D
R
A
-
L
R
E
I
R
R
E
V
G
M
V
F
Q
Q
--
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
--
M
R
V
R
-
R
-
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
--
G
I
-
L
D
Q
A
R
K
Y
--
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
-
D
V
M
R
D
L
A
-
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
-
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
-
E
E
R
T
R
S
F
L
Q
R
V
L
----
34
PsiBlast_CBE
92.74
61%
-119
- C1 -
4U02
1
?
C:
[5-242]
---
I
R
I
R
N
L
H
K
W
F
G
P
L
H
---
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
----
E
D
F
Q
E
G
E
V
V
V
D
G
-------------
L
S
V
K
D
D
R
A
-
L
R
E
I
R
R
E
V
G
M
V
F
Q
Q
--
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
--
M
R
V
R
-
R
-
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
--
G
I
-
L
D
Q
A
R
K
Y
--
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
-
D
V
M
R
D
L
A
-
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
-
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
-
E
E
R
T
R
S
F
L
Q
R
V
L
----
26
PsiBlast_CBE
92.43
67%
-118
- C1 -
2OUK
2
?
B:
[25-263]
---
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
---
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
----
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
--
M
K
V
R
-
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
--
G
L
-
K
D
K
A
H
A
Y
--
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
-
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
-
H
E
R
T
K
A
F
L
S
K
V
F
----
3
PsiBlast_PDB
92.35
67%
-116
- C1 -
2OLK
1
?
A:
[25-263]
---
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
---
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
----
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
--
M
K
V
R
-
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
--
G
L
-
K
D
K
A
H
A
Y
--
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
-
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
-
H
E
R
T
K
A
F
L
S
K
V
F
----
12
PsiBlast_PDB
92.33
61%
-116
- C1 -
4U00
3
?
A:
[5-242]
---
I
R
I
R
N
L
H
K
W
F
G
P
L
H
---
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
----
E
D
F
Q
E
G
E
V
V
V
D
G
-------------
L
S
V
K
D
D
R
A
-
L
R
E
I
R
R
E
V
G
M
V
F
Q
Q
--
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
--
M
R
V
R
-
R
-
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
--
G
I
-
L
D
Q
A
R
K
Y
--
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
-
D
V
M
R
D
L
A
-
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
-
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
-
E
E
R
T
R
S
F
L
Q
R
V
L
----
30
PsiBlast_CBE
92.28
67%
-114
- C1 -
2OLJ
3
?
B:
[25-263]
---
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
---
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
----
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
--
M
K
V
R
-
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
--
G
L
-
K
D
K
A
H
A
Y
--
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
-
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
-
H
E
R
T
K
A
F
L
S
K
V
F
----
107
Fugue
81.29
51%
-119
- C1 -
1B0U
4
HISP_SALTY
A:
[5-261]
-
N
K
L
H
V
I
D
L
H
K
R
Y
G
G
--HEV
L
K
-
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
EKPS----
E
G
A
I
I
V
N
G
QNI
N
L
V
R
D
KDGQL
K
V
A
D
K
N
Q
L
R
L
L
R
T
-
R
-
L
T
M
V
F
Q
H
--
F
N
L
W
S
H
M
T
V
L
E
N
V
M
E
A
P
--
I
Q
V
L
--G
L
S
K
H
D
A
R
E
R
A
L
K
Y
L
A
K
V
--
G
I
-
D
E
R
A
Q
G
-KY
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E-
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
-
R
I
M
Q
Q
L
A
-
E
E
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
-
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
-Q
S
P
R
L
Q
Q
F
L
K
G
S
L
K
KLE
92
PsiBlast_CBE
58.61
34%
-102
- C1 -
2FF7
1
A:
[24-241]
--------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
----
Y
I
P
E
N
G
Q
V
L
I
D
G
-------------
H
D
L
A
--
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
---
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
N
PG
M
S
V
E
-
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
RE
G
Y
-
N
T
I
V
G
E
Q
--
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
-
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
-
R
N
M
H
K
I
C
-
K
-
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
-
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
---
E
S
L
Y
S
Y
L
--------
95
PsiBlast_CBE
58.49
34%
-103
- C1 -
2FGK
2
D:
[24-241]
--------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
----
Y
I
P
E
N
G
Q
V
L
I
D
G
-------------
H
D
L
A
--
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
---
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
N
PG
M
S
V
E
-
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
RE
G
Y
-
N
T
I
V
G
E
Q
--
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
-
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
-
R
N
M
H
K
I
C
-
K
-
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
-
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
---
E
S
L
Y
S
Y
L
--------
94
PsiBlast_CBE
57.81
34%
-104
- C1 -
2PMK
1
A:
[20-237]
--------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
----
Y
I
P
E
N
G
Q
V
L
I
D
G
-------------
H
D
L
A
--
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
---
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
N
PG
M
S
V
E
-
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
RE
G
Y
-
N
T
I
V
G
E
Q
--
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
-
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
-
R
N
M
H
K
I
C
-
K
-
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
-
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
---
E
S
L
Y
S
Y
L
--------
84
PsiBlast_CBE
57.38
37%
-110
- C1 -
4MKI
4
ECFA2_CALS4
A:
[23-236]
--------------
A
T
V
---
A
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
----
L
K
P
S
K
G
K
I
Y
I
N
G
-------------
I
D
I
T
D
K
K
V
S
L
K
D
I
R
K
Q
V
G
L
V
F
Q
Y
PE
Y
Q
L
F
E
E
-
T
V
F
K
D
I
A
F
G
P
--
S
N
L
--
G
-
L
S
E
E
E
V
K
E
R
V
Y
E
A
M
E
I
V
--
G
I
S
K
E
L
A
D
K
S
--
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
-
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
-
N
K
I
K
E
I
H
D
K
Y
K
M
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
D
K
I
I
V
M
-
N
R
G
K
I
E
L
I
G
T
P
R
E
V
F
---------------------
83
PsiBlast_CBE
56.62
37%
-110
- C1 -
4MKI
4
ECFA2_CALS4
B:
[23-236]
--------------
A
T
V
---
A
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
----
L
K
P
S
K
G
K
I
Y
I
N
G
-------------
I
D
I
T
D
K
K
V
S
L
K
D
I
R
K
Q
V
G
L
V
F
Q
Y
PE
Y
Q
L
F
E
E
-
T
V
F
K
D
I
A
F
G
P
--
S
N
L
--
G
-
L
S
E
E
E
V
K
E
R
V
Y
E
A
M
E
I
V
--
G
I
S
K
E
L
A
D
K
S
--
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
-
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
-
N
K
I
K
E
I
H
D
K
Y
K
M
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
D
K
I
I
V
M
-
N
R
G
K
I
E
L
I
G
T
P
R
E
V
F
---------------------
97
PsiBlast_CBE
56.47
34%
-103
- C1 -
2FGK
2
HLYBP_ECOLX
B:
[24-241]
--------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
----
Y
I
P
E
N
G
Q
V
L
I
D
G
-------------
H
D
L
A
--
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
---
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
N
PG
M
S
V
E
-
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
RE
G
Y
-
N
T
I
V
G
E
Q
--
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
-
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
-
R
N
M
H
K
I
C
-
K
-
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
-
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
---
E
S
L
Y
S
Y
L
--------
101
PsiBlast_CBE
55.79
34%
-101
- C1 -
3FVQ
3
FBPC_NEIG1
B:
[5-232]
---
L
H
I
G
H
L
S
K
S
F
Q
N
T
P
---
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
----
E
Q
P
D
S
G
E
I
S
L
S
G
-------------
K
T
I
F
S
K
N
T
N
L
P
V
R
E
R
R
L
G
Y
L
V
Q
E
--
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
L
--
G
N
G
K
G
R
-
T
A
Q
E
R
Q
R
I
E
A
--
M
L
E
L
T
--
G
I
-
S
E
L
A
G
R
Y
--
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
-
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
-
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
-
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
-
D
---------------
98
PsiBlast_CBE
55.74
34%
-99
- C1 -
2FGK
2
HLYBP_ECOLX
A:
[24-241]
--------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
----
Y
I
P
E
N
G
Q
V
L
I
D
G
-------------
H
D
L
A
--
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
---
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
N
PG
M
S
V
E
-
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
RE
G
Y
-
N
T
I
V
G
E
Q
--
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
-
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
-
R
N
M
H
K
I
C
-
K
-
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
-
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
---
E
S
L
Y
S
Y
L
--------
102
PsiBlast_CBE
55.69
34%
-101
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[5-237]
---
L
H
I
G
H
L
S
K
S
F
Q
N
T
P
---
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
----
E
Q
P
D
S
G
E
I
S
L
S
G
-------------
K
T
I
F
S
K
N
T
N
L
P
V
R
E
R
R
L
G
Y
L
V
Q
E
--
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
L
--
G
N
G
K
G
R
-
T
A
Q
E
R
Q
R
I
E
A
--
M
L
E
L
T
--
G
I
-
S
E
L
A
G
R
Y
--
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
-
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
-
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
-
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
-
D
---------------
96
PsiBlast_CBE
55.27
34%
-101
- C1 -
2FGK
2
HLYBP_ECOLX
C:
[24-241]
--------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
----
Y
I
P
E
N
G
Q
V
L
I
D
G
-------------
H
D
L
A
--
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
---
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
N
PG
M
S
V
E
-
K
-
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
RE
G
Y
-
N
T
I
V
G
E
Q
--
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
-
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
-
R
N
M
H
K
I
C
-
K
-
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
-
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
---
E
S
L
Y
S
Y
L
--------