@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1006: (2016-03-20 )
MTKSIRPELRDIQVSGIRTFNTRVTGIPDMIRLTLGEPDFPTPDHVKQAAISAIEENFTNYTPNAGMPELLEAASIYFHEKYDLSYSNKEIIVTVGATEAISVALQTILEPGDEVILPDPIYPGYEPLITLNKAHPVKVDTTETNFKLTPEQLKAHITPKTKALIIPYPSNPTGVTLSKDELSALAEVLKETGIFVIADEIYSELTYHEEHVSIAPMLRDQTIVINGLSKSHAMIGWRIGFLLAPEILTQEMLKIHQYSVTCASSISQKAALEAITNGKDDAFQMRTEYKTRANFTQDRLEKMGFTVIPPDGAFYFFVKLPDEIAENSFDWAVKLAEEAKVAVVPGNAFSEKGDRYFRLSYATSFNNLAEALDRMAQFVEK
Atome Classification :
(25 SA)
----------.........10........20.---...-.----...30........40........50......--..60........70........80..-....--..-90........100.......110.......120.......130----.......140.--.-..-....150.......160.......170.......180.......190.......200.....--..-210...---...--.--.--220--.........230.......240.......250.......260.......270...---...---.-280...--......290.......300.-.-----.....310.......----320..--.-....330.......340.......---350....---...360.......370.......380
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------MTKSIRPEL
R
D
I
Q
V
S
G
I
R
T
FNT---RVT-G----I
P
D
M
I
R
L
TLGEPDFP
T
P
D
H
V
K
Q
A
A
I
S
A
I
E
E
N--FTNYTPNAG
M
P
E
L
L
E
A
A
S
I
Y
F
H
E
K
YD-LSYS--N
K
-
E
I
I
V
T
VG
A
T
E
A
I
S
V
A
L
Q
T
I
LEPGD
E
V
ILPDPIYPGYE
P
L
I
T
LN----KAH
P
V
K
V
DT-T--E-TN-
F
K
L
T
P
E
Q
L
K
A
HITPKT
K
A
L
I
I
PYPSNPT
G
V
T
L
S
K
D
E
L
S
A
L
A
E
V
L
K
ET
G
I
F
V
I
A
D
E
I
Y
S
E
L
T
Y
--
H
E
-E-HV
S
I
---
A
PM--L--R--D----
Q
T
I
V
I
NGLSKS
H
A
M
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G
W
R
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F
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A
P
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L
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I---TNG---K-D--
D
A
F
--
Q
M
R
T
EYKTRANF
T
Q
D
R
L
E
KM-G-----
F
T
V
IPPDG
A
F
Y
F
F
V
K----L
P
D
E
I
--A-ENSF
D
W
A
V
K
LAEE
A
K
V
A
V
VPGNAF---SEKG
D
R
Y
---
F
R
L
S
YA
T
S
F
N
N
L
A
E
A
L
D
R
M
A
Q
F
VEK
47
HHSearch
94.78
37%
-102
- C1 -
1O4S
8
AAT_THEMA
A:
[14-387]
--------------
V
S
R
R
I
S
E
I
P
I
S
K
T
M
E
L
D
A
---
K
A
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D
P
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Y
E
L
R
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G
I
A
K
R
I
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E
R
Y
K
-
K
D
I
S
P-
D
--
Q
V
V
V
T
N
G
A
K
Q
A
L
F
N
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F
M
A
L
L
D
P
G
D
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F
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Y
I
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Q
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L
A
----
G
G
T
V
N
V
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-
F
M-
S
-
K
N
-
F
Q
P
S
L
E
E
V
E
G
L
L
V
G
K
T
K
A
V
L
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P
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N
P
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V
Y
R
R
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L
V
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L
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K
K
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Y
I
I
S
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D
S
L
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Y
--
T
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T
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I
---
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E
G-
F
--
D
----
R
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Y
I
N
G
F
S
K
S
H
S
M
T
G
W
R
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G
Y
L
I
S
S
E
K
V
A
T
A
V
S
K
I
Q
S
H
T
T
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C
I
N
T
V
A
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Y
A
A
L
K
A
L
---
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V
D
---------
N
S
--
Y
M
V
Q
T
F
K
E
R
K
N
F
V
V
E
R
L
K
K
M
-
G
-----
V
K
F
V
E
P
E
G
A
F
Y
L
F
F
K
----
V
R
G
D
-------
D
V
K
F
C
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R
L
L
E
E
K
K
V
A
L
V
P
G
S
A
F
---
L
K
--
P
G
F
---
V
R
L
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F
A
T
S
I
E
R
L
T
E
A
L
D
R
I
E
D
F
L
N
-
22
PsiBlast_CBE
93.71
38%
-96
- C1 -
1GD9
2
?
B:
[2-385]
-----------
A
L
S
D
R
L
E
L
--
V
S
A
S
E
I
R
K
L
F
D
---
I
A
A
-
G
----
M
K
D
V
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
K
G
--
L
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
-
I
E
A
D
--
P
K
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
----
G
G
K
P
V
E
V
P
T
-
Y
--
E
-
E
D
E
F
R
L
N
V
D
E
L
K
K
Y
V
T
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
--
D
D
A
R
-
H
Y
S
I
---
A
S
L
DG
M
--
F
--
E
----
R
T
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T
V
N
G
F
S
K
T
F
A
M
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G
W
R
L
G
F
V
A
A
P
S
W
I
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R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
---
K
D
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---
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-
S
WK
A
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--
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M
R
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D
R
R
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W
K
R
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N
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M
-
G
-----
L
P
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K
P
K
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A
F
Y
I
F
P
R
----
I
R
D
-
T
--
G
-
L
T
S
K
K
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
---
G
K
A
G
E
G
Y
---
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
E
R
V
L
K
E
21
PsiBlast_CBE
92.79
38%
-94
- C1 -
1GDE
4
?
B:
[2-385]
-----------
A
L
S
D
R
L
E
L
--
V
S
A
S
E
I
R
K
L
F
D
---
I
A
A
-
G
----
M
K
D
V
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
K
G
--
L
T
H
Y
G
P
N
I
G
L
L
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L
R
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A
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A
E
K
L
K
K
Q
N
G
-
I
E
A
D
--
P
K
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I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
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G
E
E
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P
T
P
A
F
V
S
Y
A
P
A
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L
A
----
G
G
K
P
V
E
V
P
T
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Y
--
E
-
E
D
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F
R
L
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L
K
K
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T
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A
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N
P
T
G
A
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K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
--
D
D
A
R
-
H
Y
S
I
---
A
S
L
DG
M
--
F
--
E
----
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
---
K
D
E
---
R
-
S
WK
A
V
E
--
E
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
-
G
-----
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
R
----
I
R
D
-
T
--
G
-
L
T
S
K
K
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
---
G
K
A
G
E
G
Y
---
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
E
R
V
L
K
E
5
PsiBlast_PDB
92.49
38%
-107
- C1 -
1O4S
8
AAT_THEMA
A:
[42-386]
----------------------------------------------
D
V
I
N
L
T
A
G
E
P
D
F
P
T
P
E
P
V
V
E
E
A
V
R
F
L
Q
K
G
--
E
V
K
Y
T
D
P
R
G
I
Y
E
L
R
E
G
I
A
K
R
I
G
E
R
Y
K
-
K
D
I
S
--
P
D
-
Q
V
V
V
T
N
G
A
K
Q
A
L
F
N
A
F
M
A
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L
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P
G
D
E
V
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V
F
S
P
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W
V
S
Y
I
P
Q
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I
L
A
----
G
G
T
V
N
V
V
E
T
F
M
--
S
-
K
N
-
F
Q
P
S
L
E
E
V
E
G
L
L
V
G
K
T
K
A
V
L
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N
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N
P
T
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V
V
Y
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L
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D
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Y
D
S
L
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Y
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T
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-
E
-
F
T
S
I
---
L
D
V
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S
--
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GF
D
----
R
I
V
Y
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N
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F
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K
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M
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Y
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A
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A
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A
A
L
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A
L
---
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-----
V
-
D
--
N
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Y
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M
V
Q
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K
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V
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L
K
K
M
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G
-----
V
K
F
V
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P
E
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A
F
Y
L
F
F
K
--------
V
--
R
-
G
D
D
V
K
F
C
E
R
L
L
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K
K
V
A
L
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G
S
A
F
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K
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G
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---
V
R
L
S
F
A
T
S
I
E
R
L
T
E
A
L
D
R
I
E
D
F
L
--
45
HHSearch
91.43
38%
-95
- C1 -
1GD9
2
?
A:
[2-385]
-------------
A
L
S
D
R
L
E
L
V
S
A
S
E
I
R
K
L
F
D
---
I
A
A
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G
----
M
K
D
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I
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L
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I
G
E
P
D
F
D
T
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Q
H
I
K
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Y
A
K
E
A
L
D
K
G
--
L
T
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Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
-
I
E
A
D
PK
T
--
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
----
G
G
K
P
V
E
V
P
T
-
Y
E-
E
-
D
E
-
F
R
L
N
V
D
E
L
K
K
Y
V
T
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
--
D
D
-
A
R
H
Y
S
I
---
A
S
L
--
D
GM
F
--
E
----
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
---
K
D
E
R
S
-
W
-
K
--
A
V
E
--
E
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
-
G
-----
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
R
----
I
R
D
T
G
----
L
T
S
K
K
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
---
G
K
A
G
E
G
Y
---
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
E
R
V
L
K
E
25
PsiBlast_CBE
91.39
38%
-106
- C1 -
1O4S
4
AAT_THEMA
B:
[42-386]
----------------------------------------------
D
V
I
N
L
T
A
G
E
P
D
F
P
T
P
E
P
V
V
E
E
A
V
R
F
L
Q
K
G
--
E
V
K
Y
T
D
P
R
G
I
Y
E
L
R
E
G
I
A
K
R
I
G
E
R
Y
K
-
K
D
I
S
--
P
D
-
Q
V
V
V
T
N
G
A
K
Q
A
L
F
N
A
F
M
A
L
L
D
P
G
D
E
V
I
V
F
S
P
V
W
V
S
Y
I
P
Q
I
I
L
A
----
G
G
T
V
N
V
V
E
T
F
M
--
S
-
K
N
-
F
Q
P
S
L
E
E
V
E
G
L
L
V
G
K
T
K
A
V
L
I
N
S
P
N
N
P
T
G
V
V
Y
R
R
E
F
L
E
G
L
V
R
L
A
K
K
R
N
F
Y
I
I
S
D
E
V
Y
D
S
L
V
Y
--
T
D
-
E
-
F
T
S
I
---
L
D
V
--
S
--
E
GF
D
----
R
I
V
Y
I
N
G
F
S
K
S
H
S
M
T
G
W
R
V
G
Y
L
I
S
S
E
K
V
A
T
A
V
S
K
I
Q
S
H
T
T
S
C
I
N
T
V
A
Q
Y
A
A
L
K
A
L
---
E
-----
V
-
D
--
N
S
Y
--
M
V
Q
T
-
F
K
E
R
K
N
F
V
V
E
R
L
K
K
M
-
G
-----
V
K
F
V
E
P
E
G
A
F
Y
L
F
F
K
--------
V
--
R
-
G
D
D
V
K
F
C
E
R
L
L
E
E
K
K
V
A
L
V
P
G
S
A
F
---
L
K
P
G
--
F
---
V
R
L
S
F
A
T
S
I
E
R
L
T
E
A
L
D
R
I
E
D
F
L
--
2
PsiBlast_PDB
91.37
38%
-95
- C1 -
1GD9
2
?
A:
[2-385]
-----------
A
L
S
D
R
L
E
L
--
V
S
A
S
E
I
R
K
L
F
D
---
I
A
A
-
G
----
M
K
D
V
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
K
G
--
L
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
-
I
E
A
D
--
P
K
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
----
G
G
K
P
V
E
V
P
T
-
Y
--
E
-
E
D
E
F
R
L
N
V
D
E
L
K
K
Y
V
T
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
--
D
D
A
R
-
H
Y
S
I
---
A
S
L
DG
M
--
F
--
E
----
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
---
K
D
E
---
R
-
S
W
K
A
V
E
--
E
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
-
G
-----
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
R
----
I
R
D
-
T
--
G
-
L
T
S
K
K
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
---
G
K
A
G
E
G
Y
---
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
E
R
V
L
K
E
24
PsiBlast_CBE
89.90
37%
-103
- C1 -
1J32
2
?
B:
[31-384]
----------------------------------------------
D
V
C
S
F
S
A
G
E
P
D
F
N
T
P
K
H
I
V
E
A
A
K
A
A
L
E
Q
G
--
K
T
R
Y
G
P
A
A
G
E
P
R
L
R
E
A
I
A
Q
K
L
Q
R
D
N
G
-
L
C
Y
G
--
A
D
-
N
I
L
V
T
N
G
G
K
Q
S
I
F
N
L
M
L
A
M
I
E
P
G
D
E
V
I
I
P
A
P
F
W
V
S
Y
P
E
M
V
K
L
A
----
E
G
T
P
V
I
L
P
T
-
T
V-
E
-
T
Q
-
F
K
V
S
P
E
Q
I
R
Q
A
I
T
P
K
T
K
L
L
V
F
N
T
P
S
N
P
T
G
M
V
Y
T
P
D
E
V
R
A
I
A
Q
V
A
V
E
A
G
L
W
V
L
S
D
E
I
Y
E
K
I
L
Y
--
D
D
A
Q
-
H
L
S
I
GAA
S
P
E
--
A
--
Y
--
E
----
R
S
V
V
C
S
G
F
A
K
T
Y
A
M
T
G
W
R
V
G
F
L
A
G
P
V
P
L
V
K
A
A
T
K
I
Q
G
H
S
T
S
N
V
C
T
F
A
Q
Y
G
A
I
A
A
Y
---
E
N
S
---
Q
-
D
--
C
V
Q
--
E
M
L
A
A
F
A
E
R
R
R
Y
M
L
D
A
L
N
A
M
P
G
-----
L
E
C
P
K
P
D
G
A
F
Y
M
F
P
S
----
I
A
-
K
T
--
G
-
R
S
S
L
D
F
C
S
E
L
L
D
Q
H
Q
V
A
T
V
P
G
A
A
F
---
G
--
A
D
D
C
---
I
R
L
S
Y
A
T
D
L
D
T
I
K
R
G
M
E
R
L
E
K
F
L
--
1
PsiBlast_PDB
89.89
38%
-94
- C1 -
1GDE
4
?
A:
[2-385]
-----------
A
L
S
D
R
L
E
L
--
V
S
A
S
E
I
R
K
L
F
D
---
I
A
A
-
G
----
M
K
D
V
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
K
G
--
L
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
-
I
E
A
D
--
P
K
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
----
G
G
K
P
V
E
V
P
T
-
Y
--
E
-
E
D
E
F
R
L
N
V
D
E
L
K
K
Y
V
T
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
--
D
D
A
R
-
H
Y
S
I
---
A
S
L
DG
M
--
F
--
E
----
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
---
K
D
E
---
R
-
S
W
K
A
V
E
--
E
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
-
G
-----
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
R
----
I
R
D
-
T
--
G
-
L
T
S
K
K
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
---
G
K
A
G
E
G
Y
---
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
E
R
V
L
K
E
48
HHSearch
89.40
36%
-90
- C1 -
1J32
2
?
A:
[3-385]
--------------
L
A
A
R
V
E
S
V
S
P
S
M
T
L
I
I
D
A
K
A
K
A
M
K
A
E
----
G
I
D
V
C
S
F
S
A
G
E
P
D
F
N
T
P
K
H
I
V
E
A
A
K
A
A
L
E
Q
G
--
K
T
R
Y
G
P
A
A
G
E
P
R
L
R
E
A
I
A
Q
K
L
Q
R
D
N
G
-
L
C
Y
G
A-
D
--
N
I
L
V
T
N
G
G
K
Q
S
I
F
N
L
M
L
A
M
I
E
P
G
D
E
V
I
I
P
A
P
F
W
V
S
Y
P
E
M
V
K
L
A
----
E
G
T
P
V
I
L
P
T
-
T
--
V
E
T
Q
-
F
K
V
S
P
E
Q
I
R
Q
A
I
T
P
K
T
K
L
L
V
F
N
T
P
S
N
P
T
G
M
V
Y
T
P
D
E
V
R
A
I
A
Q
V
A
V
E
A
G
L
W
V
L
S
D
E
I
Y
E
K
I
L
Y
--
D
D
-
A
Q
H
L
S
I
---
G
A
A
S
P
E
A
-
Y
--
E
----
R
S
V
V
C
S
G
F
A
K
T
Y
A
M
T
G
W
R
V
G
F
L
A
G
P
V
P
L
V
K
A
A
T
K
I
Q
G
H
S
T
S
N
V
C
T
F
A
Q
Y
G
A
I
A
A
Y
---
E
N
S
---
Q
-
D
--
C
V
Q
--
E
M
L
A
A
F
A
E
R
R
R
Y
M
L
D
A
L
N
A
M
P
G
-----
L
E
C
P
K
P
D
G
A
F
Y
M
F
P
S
----
I
A
K
T
G
----
R
S
S
L
D
F
C
S
E
L
L
D
Q
H
Q
V
A
T
V
P
G
A
A
F
---
G
A
--
D
D
C
---
I
R
L
S
Y
A
T
D
L
D
T
I
K
R
G
M
E
R
L
E
K
F
L
H
-
40
PsiBlast_CBE
89.20
38%
-99
- C1 -
1BKG
3
AAT_THET8
C:
[22-382]
---------------------------
K
A
L
E
L
---
R
R
Q
-
G
----
V
-
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
--
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
-
L
S
V
T
--
P
E
-
E
T
I
V
T
V
G
G
K
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
----
G
G
V
V
V
E
V
E
T
-
L
P-
E
-
E
G
-
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
--
E
G
-
E
-
H
F
S
P
---
G
R
V
--
A
--
P
--
E
----
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
S
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
---
T
N
Q
---
E
A
S
--
R
A
F
VE
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
-----
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
TSPI
A
P
D
E
V
--
R
-------
A
A
E
R
L
L
E
A
G
V
A
V
V
P
G
T
D
F
---
A
A
F
G
--
H
---
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
--
39
PsiBlast_CBE
88.93
38%
-99
- C1 -
1BKG
3
AAT_THET8
D:
[22-382]
---------------------------
K
A
L
E
L
---
R
R
Q
-
G
----
V
-
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
--
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
-
L
S
V
T
--
P
E
-
E
T
I
V
T
V
G
G
K
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
----
G
G
V
V
V
E
V
E
T
-
L
P-
E
-
E
G
-
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
--
E
G
-
E
-
H
F
S
P
---
G
R
V
--
A
--
P
--
E
----
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
S
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
---
T
N
Q
---
E
A
S
--
R
A
F
VE
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
-----
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
TSPI
A
P
D
E
V
--
R
-------
A
A
E
R
L
L
E
A
G
V
A
V
V
P
G
T
D
F
---
A
A
F
G
--
H
---
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
--
23
PsiBlast_CBE
88.70
38%
-104
- C1 -
1DJU
2
?
B:
[3-384]
-------------
S
D
R
L
E
L
--
V
S
-----------------------
D
V
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
K
G
--
L
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
-
I
E
A
D
--
P
K
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
----
G
G
K
P
V
E
V
P
T
-
Y
--
E
-
E
D
E
F
R
L
N
V
D
E
L
K
K
Y
V
T
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
--
D
D
A
R
-
H
Y
S
I
---
A
S
L
DG
M
--
F
--
E
----
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
---
K
D
E
---
R
-
S
W
K
A
V
E
--
E
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
-
G
-----
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
R
----
I
R
D
-
T
--
G
-
L
T
S
K
K
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
---
G
K
A
G
E
G
Y
---
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
E
R
M
E
R
V
L
K
E
68
Fugue
88.63
38%
-101
- C1 -
1BJW
1
AAT_THET8
A:
[1-382]
M
R
G
L
S
R
R
V
Q
A
M
K
---
P
S
A
T
V
A
V
N
A
K
A
L
E
L
R
R
Q
------------
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
--
Q
G
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L-
S
V
T
--
P
E
-
E
T
I
V
T
V
G
G
K
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
-
A
G
G
V
-
V
V
E
V
E
T
-
L
-
P
--
E
-
E
G
-
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
---
E
-
H
F
S
P
---
G
R
----------VAPE
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
S
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
N
Q
E
A
S
---
R
-
A
--
F
V
E
--
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
--
G
L
K
A
V----
R
P
S
G
A
F
Y
V
L
M
D
----
T
S
---PI
A
-
P
D
E
V
R
A
A
E
R
L
L
E
-
A
G
V
A
V
V
P
G
T
D
F
---
A
A
--
F
G
H
---
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
--
4
PsiBlast_PDB
88.59
37%
-98
- C1 -
1J32
2
?
A:
[31-384]
----------------------------------------------
D
V
C
S
F
S
A
G
E
P
D
F
N
T
P
K
H
I
V
E
A
A
K
A
A
L
E
Q
G
--
K
T
R
Y
G
P
A
A
G
E
P
R
L
R
E
A
I
A
Q
K
L
Q
R
D
N
G
-
L
C
Y
G
--
A
D
-
N
I
L
V
T
N
G
G
K
Q
S
I
F
N
L
M
L
A
M
I
E
P
G
D
E
V
I
I
P
A
P
F
W
V
S
Y
P
E
M
V
K
L
A
----
E
G
T
P
V
I
L
P
T
-
T
V-
E
-
T
Q
-
F
K
V
S
P
E
Q
I
R
Q
A
I
T
P
K
T
K
L
L
V
F
N
T
P
S
N
P
T
G
M
V
Y
T
P
D
E
V
R
A
I
A
Q
V
A
V
E
A
G
L
W
V
L
S
D
E
I
Y
E
K
I
L
Y
--
D
D
A
Q
-
H
L
S
I
GAA
S
P
E
--
A
--
Y
--
E
----
R
S
V
V
C
S
G
F
A
K
T
Y
A
M
T
G
W
R
V
G
F
L
A
G
P
V
P
L
V
K
A
A
T
K
I
Q
G
H
S
T
S
N
V
C
T
F
A
Q
Y
G
A
I
A
A
Y
---
E
N
S
---
Q
-
D
--
C
V
Q
--
E
M
L
A
A
F
A
E
R
R
R
Y
M
L
D
A
L
N
A
M
P
G
-----
L
E
C
P
K
P
D
G
A
F
Y
M
F
P
S
----
I
A
-
K
T
--
G
-
R
S
S
L
D
F
C
S
E
L
L
D
Q
H
Q
V
A
T
V
P
G
A
A
F
---
G
--
A
D
D
C
---
I
R
L
S
Y
A
T
D
L
D
T
I
K
R
G
M
E
R
L
E
K
F
L
--
11
PsiBlast_PDB
88.50
38%
-99
- C1 -
1BKG
4
AAT_THET8
A:
[22-382]
---------------------------
K
A
L
E
L
---
R
R
Q
-
G
----
V
-
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
--
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
-
L
S
V
T
--
P
E
-
E
T
I
V
T
V
G
G
K
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
----
G
G
V
V
V
E
V
E
T
-
L
P-
E
-
E
G
-
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
--
E
G
-
E
-
H
F
S
P
---
G
R
V
--
A
--
P
--
E
----
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
S
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
---
T
N
Q
---
E
A
S
--
R
A
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
-----
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
TSPI
A
P
D
E
V
--
R
-------
A
A
E
R
L
L
E
A
G
V
A
V
V
P
G
T
D
F
---
A
A
F
G
--
H
---
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
--
12
PsiBlast_PDB
88.14
38%
-101
- C1 -
1BJW
1
AAT_THET8
A:
[22-382]
---------------------------
K
A
L
E
L
---
R
R
Q
-
G
----
V
-
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
--
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
-
L
S
V
T
--
P
E
-
E
T
I
V
T
V
G
G
K
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
----
G
G
V
V
V
E
V
E
T
-
L
P-
E
-
E
G
-
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
--
E
G
-
E
-
H
F
S
P
---
G
R
V
--
A
--
P
--
E
----
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
S
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
---
T
N
Q
---
E
A
S
--
R
A
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
-----
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
TSPI
A
P
D
E
V
--
R
-------
A
A
E
R
L
L
E
A
G
V
A
V
V
P
G
T
D
F
---
A
A
F
G
--
H
---
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
--
3
PsiBlast_PDB
88.07
38%
-100
- C1 -
1DJU
2
?
A:
[3-384]
-------------
S
D
R
L
E
L
--
V
S
A
---------------------
K
D
V
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
K
G
--
L
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
-
I
E
A
D
--
P
K
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
----
G
G
K
P
V
E
V
P
T
-
Y
--
E
-
E
D
E
F
R
L
N
V
D
E
L
K
K
Y
V
T
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
--
D
D
A
R
-
H
Y
S
I
---
A
S
L
DG
M
--
F
--
E
----
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
---
K
D
E
---
R
-
S
W
K
A
V
E
--
E
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
-
G
-----
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
R
----
I
R
D
-
T
--
G
-
L
T
S
K
K
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
---
G
K
A
G
E
G
Y
---
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
E
R
M
E
R
V
L
K
E
41
PsiBlast_CBE
87.90
38%
-99
- C1 -
1BKG
3
AAT_THET8
B:
[22-382]
---------------------------
K
A
L
E
L
---
R
R
Q
-
G
----
V
-
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
--
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
-
L
S
V
T
--
P
E
-
E
T
I
V
T
V
G
G
K
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
----
G
G
V
V
V
E
V
E
T
-
L
P-
E
-
E
G
-
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
--
E
G
-
E
-
H
F
S
P
---
G
R
V
--
A
--
P
--
E
----
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
S
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
---
T
N
Q
---
E
A
S
--
R
A
F
VE
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
-----
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
TSPI
A
P
D
E
V
--
R
-------
A
A
E
R
L
L
E
A
G
V
A
V
V
P
G
T
D
F
---
A
A
F
G
--
H
---
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
--
10
PsiBlast_PDB
87.41
38%
-99
- C1 -
1B5O
3
AAT_THET8
A:
[22-382]
---------------------------
K
A
L
E
L
---
R
R
Q
-
G
----
V
-
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
--
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
-
L
S
V
T
--
P
E
-
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
----
G
G
V
V
V
E
V
E
T
-
L
P-
E
-
E
G
-
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
--
E
G
-
E
-
H
F
S
P
---
G
R
V
--
A
--
P
--
E
----
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
S
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
---
T
N
Q
---
E
A
S
--
R
A
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
-----
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
TSPI
A
P
D
E
V
--
R
-------
A
A
E
R
L
L
E
A
G
V
A
V
V
P
G
T
D
F
---
A
A
F
G
--
H
---
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
--
26
PsiBlast_CBE
87.15
38%
-100
- C1 -
1GCK
4
AAT_THET8
B:
[22-382]
---------------------------
K
A
L
E
L
---
R
R
Q
-
G
----
V
-
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
--
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
-
L
S
V
T
--
P
E
-
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
----
G
G
V
V
V
E
V
E
T
-
L
P-
E
-
E
G
-
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
--
E
G
-
E
-
H
F
S
P
---
G
R
V
--
A
--
P
--
E
----
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
---
T
N
Q
---
E
A
S
--
R
A
F
VE
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
-----
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
TSPI
A
P
D
E
V
--
R
-------
A
A
E
R
L
L
E
A
G
V
A
V
V
P
G
T
D
F
---
A
A
F
G
--
H
---
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
--
54
HHSearch
86.60
39%
-100
* C1 *
1B5P
3
AAT_THET8
A:
[30-382]
--------------------------------------------
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
--
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
-
L
S
V
T
P-
E
--
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
----
G
G
V
V
V
E
V
E
T
-
L
P-
E
-
E
G
-
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
--
E
G
-
E
-
H
F
S
P
---
G
R
V
--
A
--
P
--
E
----
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
---
T
N
Q
E
A
S
R
-
A
--
F
V
E
--
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
-----
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
----
T
S
P
I
A
----
P
D
E
V
R
A
A
E
R
L
L
-
E
A
G
V
A
V
V
P
G
T
D
F
---
A
A
--
F
G
H
---
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
--
38
PsiBlast_CBE
86.42
38%
-98
- C1 -
1B5O
3
AAT_THET8
B:
[22-382]
---------------------------
K
A
L
E
L
---
R
R
Q
-
G
----
V
-
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
--
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
-
L
S
V
T
--
P
E
-
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
----
G
G
V
V
V
E
V
E
T
-
L
P-
E
-
E
G
-
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
--
E
G
-
E
-
H
F
S
P
---
G
R
V
--
A
--
P
--
E
----
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
S
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
---
T
N
Q
---
E
A
S
--
R
A
F
VE
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
-----
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
TSPI
A
P
D
E
V
--
R
-------
A
A
E
R
L
L
E
A
G
V
A
V
V
P
G
T
D
F
---
A
A
F
G
--
H
---
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
--
27
PsiBlast_CBE
85.72
38%
-99
- C1 -
1B5P
3
AAT_THET8
B:
[22-382]
---------------------------
K
A
L
E
L
---
R
R
Q
-
G
----
V
-
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
--
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
-
L
S
V
T
--
P
E
-
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
----
G
G
V
V
V
E
V
E
T
-
L
P-
E
-
E
G
-
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
--
E
G
-
E
-
H
F
S
P
---
G
R
V
--
A
--
P
--
E
----
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
---
T
N
Q
---
E
A
S
--
R
A
F
VE
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
-----
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
TSPI
A
P
D
E
V
--
R
-------
A
A
E
R
L
L
E
A
G
V
A
V
V
P
G
T
D
F
---
A
A
F
G
--
H
---
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
--
20
PsiBlast_PDB
81.22
30%
-98
- C1 -
2O0R
3
DAPC_MYCTU
A:
[28-394]
------------------------------------------------
V
N
L
G
Q
G
F
P
D
E
D
G
P
P
K
M
L
Q
A
A
Q
D
A
I
A
G
G
--
V
N
Q
Y
P
P
G
P
G
S
A
P
L
R
R
A
I
A
A
Q
R
R
R
H
F
G
-
V
D
Y
D
P-
E
T
-
E
V
L
V
T
V
G
A
T
E
A
I
A
A
A
V
L
G
L
V
E
P
G
S
E
V
L
L
I
E
P
F
Y
D
S
Y
S
P
V
V
A
M
A
----
G
A
H
R
V
T
V
P
L
-
V
P
D
G
-
R
G
-
F
A
L
D
A
D
A
L
R
R
A
V
T
P
R
T
R
A
L
I
I
N
S
P
H
N
P
T
G
A
V
L
S
A
T
E
L
A
A
I
A
E
I
A
V
A
A
N
L
V
V
I
T
D
E
V
Y
E
H
L
V
F
D-
H
A
-
R
-
H
L
P
L
---
A
G
F
DG
M
--
A
--
E
----
R
T
I
T
I
S
S
A
A
K
M
F
N
C
T
G
W
K
I
G
W
A
C
G
P
A
E
L
I
A
G
V
R
A
A
K
Q
Y
L
S
Y
V
G
G
A
P
F
Q
P
A
V
A
L
A
L
---
D
T
E
---
D
-
A
--
W
V
A
--
A
L
R
N
S
L
R
A
R
R
D
R
L
A
A
G
L
T
E
I
-
G
-----
F
A
V
H
D
S
Y
G
T
-
Y
F
L
C
A
----
D
P
R
P
L
--
G
Y
D
D
S
T
E
F
C
A
A
L
P
E
K
V
G
V
A
A
I
P
M
S
A
F
CDP---
A
D
V
W
N
H
L
V
R
F
T
F
C
K
R
D
D
T
L
D
E
A
I
R
R
L
S
V
L
A
E
-