@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2551: (2016-04-04 )
MAKLSIAYLESLTIKDIYSLAKEHKIAYYSKLTKRELIFALLKSNAEKEGFFFMEGVLEIIPNEGFGFLRPINYSSSSEDIYISASQIRRFELRTGDRVSGKVRPPKENERYFGLLHVEAVNGENPEVAKERVHFPGLTPLYPDRQIHLETEKYPISTRTIDLIAPIGFGQRGLIVAPPKAGKTVLLKEIANAITTNHPDTELIVLLIDERPEEVTDIERSVKADVVSSTFDEVPENHIKVAELVLERAMRLVEQKRDVVILMDSITRLARAYNLVIPPSGRTLSGGIDPAAFHRPKRFFGAARNIEEGGSLTILATALVDTGSRMDDVIYEEFKGTGNMELHLDRQLAERRVFPAIDMRRSGTRKEELLLSKERLEQLWKIRKAMPKQGDGLDISERFVRYLKKTDNNEAFYELLQEEMFKK
Atome Classification :
(25 SA)
.........10........20........30........40........50........60........70..--......80........90........100.......110.......120.......130.......140.......150-.........160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MA
K
L
S
I
A
Y
L
E
S
L
T
I
K
D
I
Y
S
L
A
K
E
H
K
I
A
Y
Y
S
K
L
T
K
R
E
L
I
F
A
L
L
KSNAEKEG
F
F
F
M
E
G
V
L
E
IIPNEGFGFLRPIN--YSSSSE
D
I
Y
I
S
A
S
Q
I
R
R
F
E
LRTGDRVSGKVRPPKENE
R
Y
F
G
L
L
H
V
E
AVNGE
N
P
E
V
A
K
E
RVHFPGLTPLYPD
R
Q
I
H
L
E---TEKYPIS
T
R
T
I
D
L
I
A
PIGFGQRG
L
I
V
APPKAGK
T
V
L
L
K
E
I
A
N
A
I
TTNHPD
T
E
L
I
V
L
L
IDERP
E
E
V
T
D
I
E
R
S
V
K
A
D
V
V
S
S
T
F
D
EV
P
E
N
H
I
K
V
A
E
L
V
L
E
R
A
M
R
L
V
E
QKR
D
V
V
I
L
M
D
S
I
T
R
L
A
R
A
Y
N
L
V
IPPSGRTLSGGI
D
P
A
A
FH
R
P
K
R
F
F
GAARNIEEGG
S
L
T
I
L
A
T
A
L
VDTGS
R
M
D
D
V
I
Y
E
E
FKGTGN
M
E
L
H
L
D
R
Q
L
A
ERRVFPAIDMRRSGT
R
K
E
E
L
L
L
S
K
E
R
L
E
Q
L
W
K
I
R
K
AMPKQGDGL
D
I
S
E
R
F
V
R
Y
L
K
KTDN
N
E
A
F
Y
E
L
L
Q
E
E
MFKK
29
PsiBlast_CBE
94.65
55%
-99
- C4 -
1XPR
5
RHO_ECOLI
C:
[1-417]
---
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
-
Q
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
-
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
------
38
PsiBlast_CBE
93.07
55%
-98
- C4 -
1PVO
3
RHO_ECOLI
D:
[1-417]
---
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
-
Q
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
-
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
------
32
PsiBlast_CBE
92.61
55%
-92
- C4 -
1XPO
6
RHO_ECOLI
E:
[1-417]
---
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
-
Q
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
----
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
-
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
------
25
PsiBlast_CBE
92.46
55%
-94
- C4 -
1XPU
6
RHO_ECOLI
B:
[1-417]
---
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
-
Q
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
-
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
------
36
PsiBlast_CBE
92.22
55%
-97
- C4 -
1PVO
2
RHO_ECOLI
F:
[1-417]
---
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
-
Q
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
-
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
------
23
PsiBlast_CBE
92.05
55%
-92
- C4 -
1XPU
5
RHO_ECOLI
D:
[1-417]
---
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
-
Q
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
-
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
------
3
PsiBlast_PDB
92.00
55%
-97
- C6 -
1XPU
5
RHO_ECOLI
A:
[1-417]
---
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
-
Q
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
-
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
------
28
PsiBlast_CBE
91.98
55%
-93
- C4 -
1XPR
4
RHO_ECOLI
D:
[1-417]
---
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
-
Q
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
-
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
------
26
PsiBlast_CBE
91.83
55%
-93
- C4 -
1XPR
6
RHO_ECOLI
F:
[1-417]
---
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
-
Q
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
-
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
------
1
PsiBlast_PDB
91.70
55%
-97
- C6 -
1PVO
3
RHO_ECOLI
A:
[1-417]
---
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
-
Q
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
-
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
------
24
PsiBlast_CBE
91.66
55%
-91
- C4 -
1XPU
6
RHO_ECOLI
C:
[1-417]
---
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
-
Q
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
-
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
------
2
PsiBlast_PDB
91.45
55%
-92
- C4 -
1XPR
5
RHO_ECOLI
A:
[1-417]
---
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
-
Q
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
-
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
------
37
PsiBlast_CBE
91.14
55%
-96
- C4 -
1PVO
3
RHO_ECOLI
E:
[1-417]
---
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
-
Q
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
----
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
-
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
------
21
PsiBlast_CBE
91.13
55%
-96
- C4 -
1XPU
5
RHO_ECOLI
F:
[1-417]
---
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
-
Q
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
-
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
------
39
PsiBlast_CBE
91.02
55%
-95
- C4 -
1PVO
3
RHO_ECOLI
C:
[1-417]
---
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
-
Q
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
-
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
------
27
PsiBlast_CBE
90.91
55%
-96
- C4 -
1XPR
7
RHO_ECOLI
E:
[1-417]
---
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
-
Q
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
----
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
-
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
------
34
PsiBlast_CBE
90.61
55%
-99
- C4 -
1XPO
6
RHO_ECOLI
C:
[1-417]
---
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
-
Q
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
-
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
------
22
PsiBlast_CBE
90.59
55%
-91
- C4 -
1XPU
6
RHO_ECOLI
E:
[1-417]
---
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
-
Q
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
----
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
-
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
------
35
PsiBlast_CBE
90.48
55%
-90
- C4 -
1XPO
6
RHO_ECOLI
B:
[1-417]
---
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
-
Q
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
-
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
------
33
PsiBlast_CBE
90.43
55%
-96
- C4 -
1XPO
6
RHO_ECOLI
D:
[1-417]
---
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
-
Q
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
-
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
------
4
PsiBlast_PDB
90.09
55%
-92
- C4 -
1XPO
5
RHO_ECOLI
A:
[1-417]
---
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
-
Q
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
-
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
------
30
PsiBlast_CBE
90.06
55%
-96
- C4 -
1XPR
6
RHO_ECOLI
B:
[1-417]
---
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
-
Q
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
-
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
------
31
PsiBlast_CBE
88.95
55%
-90
- C4 -
1XPO
5
RHO_ECOLI
F:
[1-417]
---
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
-
Q
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
P
M
G
E
-
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
------
41
PsiBlast_CBE
74.76
55%
-92
- C4 -
2HT1
3
RHO_ECOLI
B:
[53-376]
---------------------------------
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
-
Q
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
A
R
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
E
RGN
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
S
G
K
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
----------------------------------------------------------------------
5
PsiBlast_PDB
74.11
55%
-93
- C4 -
2HT1
3
RHO_ECOLI
A:
[53-376]
---------------------------------
K
Q
D
I
I
F
A
I
L
K
Q
H
A
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