@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0331: (2015-11-30 )
MVFAKISQLAHYAPSQIIKNEDLSLIMDTSDDWISSRTGIKQRHISKNETTADLANKVAEQLIEKSGYSASQIDFIIVATMTPDSMMPSTAARVQAHIGASNAFAFDLSAACSGFVFALSTAEKLISSGSYQKGLVIGAETVSKVLDWTDRGTAVLFGDGAGGVLLEASKEKHFLAESLNTDGSRQGLQSSQVGLNSPFSDEVLDDKFLKMDGRAIFDFAIKEVSKSINHLIETSYLEKEDIDYLFLHQANRRILDKMSRKIDIARDKFPENMMDYGNTSAASIPILLSESYENGLLKLDGNQTILLSGFGGGLTWGSLIVKI
Atome Classification :
(21 SA)
.........10........20........30........40.....-...50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170..-......180..-..-...190....-...-200.....--..210.......220.......230.......240.......250.......260.......270........280.......290.......300.......310.......320.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
V
F
A
K
I
S
Q
L
A
HYA
P
S
Q
I
IKNED
L
S
L
I
M
DTSD
D
W
I
S
SRTGI
K
Q
RHIS-KNE
T
T
A
D
L
A
N
K
V
A
E
Q
L
I
E
KSGYSA
S
Q
I
D
F
I
I
V
A
TMTPDSMMP
S
T
A
A
R
V
Q
A
HIGASN
A
F
A
F
D
L
S
A
A
CS
G
F
V
F
A
L
S
T
A
E
K
L
I
SSGSYQK
G
L
V
I
G
A
E
T
V
S
K
V
LDWTDRG
T
A
V
L
F
GDGAG
G
V
L
L
EASKE-
K
H
-
F
L
A
E
SLNTDGS-RQ-GLQSSQVGLN-SPF-SDEVLD
D
K
--
F
L
KMDG
R
A
I
F
D
F
A
I
K
E
V
S
K
S
I
N
H
L
I
E
T
SYLEKEDI
D
Y
L
F
L
H
QA
N
R
R
I
L
D
K
M
S
R
KIDI
A
R
DKF
P
E
-
N
M
M
DYGNTSA
A
S
I
P
I
L
L
SESYEN
G
L
L
K
LDGN
Q
T
I
L
L
SGFGGGL
T
W
G
S
L
I
V
KI
22
PsiBlast_CBE
99.19
58%
-91
- C1 -
3IL5
1
FABH_ENTFA
C:
[24-341]
--
Y
A
R
I
S
C
T
S
R
Y
V
P
E
N
C
V
T
N
H
Q
L
S
E
M
M
D
T
S
D
E
W
I
H
S
R
T
G
I
S
E
R
R
I
V
-
T
Q
E
N
T
S
D
L
C
H
Q
V
A
K
Q
L
L
E
K
S
G
K
Q
A
S
E
I
D
F
I
L
V
A
T
V
T
P
D
F
N
M
P
S
V
A
C
Q
V
Q
G
A
I
G
A
T
E
A
F
A
F
D
I
S
A
A
C
S
G
F
V
Y
A
L
S
M
A
E
K
L
V
L
S
G
R
Y
Q
T
G
L
V
I
G
G
E
T
F
S
K
M
L
D
W
T
D
R
S
T
A
V
L
F
G
D
G
A
A
G
V
L
I
E
A
A
E
T
-
P
H
-
F
L
N
E
K
L
Q
A
D
G
Q
-
R
W
-
A
A
L
T
S
G
Y
T
I
N
E
S
P
F
Y
Q
G
H
K
Q
A
S
K
--
T
L
Q
M
E
G
R
S
I
F
D
F
A
I
K
D
V
S
Q
N
I
L
S
L
V
-----
T
D
E
T
V
D
Y
L
L
L
H
Q
A
N
V
R
I
I
D
K
I
A
R
K
T
K
I
S
R
E
K
F
L
T
-
N
M
D
K
Y
G
N
T
S
A
A
S
I
P
I
L
L
D
E
A
V
E
N
G
T
L
I
L
G
S
Q
Q
R
V
V
L
T
G
F
G
G
G
L
T
W
G
S
L
L
L
T
L
1
PsiBlast_PDB
99.08
58%
-92
- C1 -
3IL5
1
FABH_ENTFA
A:
[24-341]
--
Y
A
R
I
S
C
T
S
R
Y
V
P
E
N
C
V
T
N
H
Q
L
S
E
M
M
D
T
S
D
E
W
I
H
S
R
T
G
I
S
E
R
R
I
V
-
T
Q
E
N
T
S
D
L
C
H
Q
V
A
K
Q
L
L
E
K
S
G
K
Q
A
S
E
I
D
F
I
L
V
A
T
V
T
P
D
F
N
M
P
S
V
A
C
Q
V
Q
G
A
I
G
A
T
E
A
F
A
F
D
I
S
A
A
C
S
G
F
V
Y
A
L
S
M
A
E
K
L
V
L
S
G
R
Y
Q
T
G
L
V
I
G
G
E
T
F
S
K
M
L
D
W
T
D
R
S
T
A
V
L
F
G
D
G
A
A
G
V
L
I
E
A
A
E
T
-
P
H
-
F
L
N
E
K
L
Q
A
D
G
Q
-
R
W
-
A
A
L
T
S
G
Y
T
I
N
E
S
P
F
Y
Q
G
H
K
Q
A
S
K
--
T
L
Q
M
E
G
R
S
I
F
D
F
A
I
K
D
V
S
Q
N
I
L
S
L
V
-----
T
D
E
T
V
D
Y
L
L
L
H
Q
A
N
V
R
I
I
D
K
I
A
R
K
T
K
I
S
R
E
K
F
L
T
-
N
M
D
K
Y
G
N
T
S
A
A
S
I
P
I
L
L
D
E
A
V
E
N
G
T
L
I
L
G
S
Q
Q
R
V
V
L
T
G
F
G
G
G
L
T
W
G
S
L
L
L
T
L
21
PsiBlast_CBE
97.99
58%
-94
- C1 -
3IL5
1
FABH_ENTFA
D:
[24-341]
--
Y
A
R
I
S
C
T
S
R
Y
V
P
E
N
C
V
T
N
H
Q
L
S
E
M
M
D
T
S
D
E
W
I
H
S
R
T
G
I
S
E
R
R
I
V
-
T
Q
E
N
T
S
D
L
C
H
Q
V
A
K
Q
L
L
E
K
S
G
K
Q
A
S
E
I
D
F
I
L
V
A
T
V
T
P
D
F
N
M
P
S
V
A
C
Q
V
Q
G
A
I
G
A
T
E
A
F
A
F
D
I
S
A
A
C
S
G
F
V
Y
A
L
S
M
A
E
K
L
V
L
S
G
R
Y
Q
T
G
L
V
I
G
G
E
T
F
S
K
M
L
D
W
T
D
R
S
T
A
V
L
F
G
D
G
A
A
G
V
L
I
E
A
A
E
T
-
P
H
-
F
L
N
E
K
L
Q
A
D
G
Q
-
R
W
-
A
A
L
T
S
G
Y
T
I
N
E
S
P
F
Y
Q
G
H
K
Q
A
S
K
--
T
L
Q
M
E
G
R
S
I
F
D
F
A
I
K
D
V
S
Q
N
I
L
S
L
V
-----
T
D
E
T
V
D
Y
L
L
L
H
Q
A
N
V
R
I
I
D
K
I
A
R
K
T
K
I
S
R
E
K
F
L
T
-
N
M
D
K
Y
G
N
T
S
A
A
S
I
P
I
L
L
D
E
A
V
E
N
G
T
L
I
L
G
S
Q
Q
R
V
V
L
T
G
F
G
G
G
L
T
W
G
S
L
L
L
T
L
23
PsiBlast_CBE
97.53
58%
-92
- C1 -
3IL5
1
FABH_ENTFA
B:
[24-341]
--
Y
A
R
I
S
C
T
S
R
Y
V
P
E
N
C
V
T
N
H
Q
L
S
E
M
M
D
T
-
D
E
W
I
H
S
R
T
G
I
S
E
R
R
I
V
-
T
Q
E
N
T
S
D
L
C
H
Q
V
A
K
Q
L
L
E
K
S
G
K
Q
A
S
E
I
D
F
I
L
V
A
T
V
T
P
D
F
N
M
P
S
V
A
C
Q
V
Q
G
A
I
G
A
T
E
A
F
A
F
D
I
S
A
A
C
S
G
F
V
Y
A
L
S
M
A
E
K
L
V
L
S
G
R
Y
Q
T
G
L
V
I
G
G
E
T
F
S
K
M
L
D
W
T
D
R
S
T
A
V
L
F
G
D
G
A
A
G
V
L
I
E
A
A
E
T
-
P
H
-
F
L
N
E
K
L
Q
A
D
G
Q
-
R
W
-
A
A
L
T
S
G
Y
T
I
N
E
S
P
F
Y
Q
G
H
K
Q
A
S
K
--
T
L
Q
M
E
G
R
S
I
F
D
F
A
I
K
D
V
S
Q
N
I
L
S
L
V
-----
T
D
E
T
V
D
Y
L
L
L
H
Q
A
N
V
R
I
I
D
K
I
A
R
K
T
K
I
S
R
E
K
F
L
T
-
N
M
D
K
Y
G
N
T
S
A
A
S
I
P
I
L
L
D
E
A
V
E
N
G
T
L
I
L
G
S
Q
Q
R
V
V
L
T
G
F
G
G
G
L
T
W
G
S
L
L
L
T
L
2
PsiBlast_PDB
95.43
58%
-89
- C1 -
3IL4
1
FABH_ENTFA
A:
[3-320]
--
Y
A
R
I
S
C
T
S
R
Y
V
P
E
N
C
V
T
N
H
Q
L
S
E
M
M
D
T
S
D
E
W
I
H
S
R
T
G
I
S
E
R
R
I
V
-
T
Q
E
N
T
S
D
L
C
H
Q
V
A
K
Q
L
L
E
K
S
G
K
Q
A
S
E
I
D
F
I
L
V
A
T
V
T
P
D
F
N
M
P
S
V
A
C
Q
V
Q
G
A
I
G
A
T
E
A
F
A
F
D
I
S
A
A
C
S
G
F
V
Y
A
L
S
M
A
E
K
L
V
L
S
G
R
Y
Q
T
G
L
V
I
G
G
E
T
F
S
K
M
L
D
W
T
D
R
S
T
A
V
L
F
G
D
G
A
A
G
V
L
I
E
A
A
E
T
-
P
H
-
F
L
N
E
K
L
Q
A
D
G
Q
-
R
W
-
T
A
L
T
S
G
Y
T
I
N
E
S
P
F
Y
Q
G
H
K
--
S
K
--
T
L
Q
M
E
G
R
S
I
F
D
F
A
I
K
D
V
S
Q
N
I
L
S
L
V
-----
T
D
E
T
V
D
Y
L
L
L
H
Q
A
S
V
R
I
I
D
K
I
A
R
K
T
K
I
S
R
E
K
F
L
T
-
N
M
D
K
Y
G
N
T
S
A
A
S
I
P
I
L
L
D
E
A
V
E
N
G
T
L
I
L
G
S
Q
Q
R
V
V
L
T
G
F
G
G
G
L
T
W
G
S
L
L
L
T
L
8
PsiBlast_PDB
87.73
37%
-90
- C1 -
1HND
1
FABH_ECOLI
A:
[1-316]
-
M
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
N
E
T
V
S
T
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
S
E
E
-
P
G
-
I
I
S
T
H
L
H
A
D
G
S
-
Y
G
-
E
L
------
L
T
-
L
P
N
-
A
D
R
V
N
P
E
N
SI
H
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
S
M
D
N
V
V
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
D
G
R
I
K
--
P
G
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
32
PsiBlast_CBE
87.69
37%
-88
- C1 -
2EFT
4
FABH_ECOLI
B:
[1-316]
-
M
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
N
E
T
V
S
T
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
S
E
E
-
P
G
-
I
I
S
T
H
L
H
A
D
G
S
-
Y
G
-
E
L
------
L
T
-
L
P
N
-
A
D
R
V
N
P
E
N
SI
H
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
S
M
D
N
V
V
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
D
G
R
I
K
--
P
G
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
31
PsiBlast_CBE
87.48
37%
-86
- C1 -
2GYO
3
FABH_ECOLI
B:
[1-316]
-
M
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
N
E
T
V
S
T
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
S
E
E
-
P
G
-
I
I
S
T
H
L
H
A
D
G
S
-
Y
G
-
E
L
------
L
T
-
L
P
N
-
A
D
R
V
N
P
E
N
SI
H
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
S
M
D
N
V
V
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
D
G
R
I
K
--
P
G
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
9
PsiBlast_PDB
87.47
37%
-87
- C1 -
1HNJ
2
FABH_ECOLI
A:
[1-316]
-
M
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
N
E
T
V
S
T
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
S
E
E
-
P
G
-
I
I
S
T
H
L
H
A
D
G
S
-
Y
G
-
E
L
------
L
T
-
L
P
N
-
A
D
R
V
N
P
E
N
SI
H
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
S
M
D
N
V
V
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
D
G
R
I
K
--
P
G
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
7
PsiBlast_PDB
86.80
37%
-86
- C1 -
1HN9
1
FABH_ECOLI
A:
[1-316]
-
M
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
N
E
T
V
S
T
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
S
E
E
-
P
G
-
I
I
S
T
H
L
H
A
D
G
S
-
Y
G
-
E
L
------
L
T
-
L
P
N
-
A
D
R
V
N
P
E
N
SI
H
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
S
M
D
N
V
V
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
D
G
R
I
K
--
P
G
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
16
PsiBlast_PDB
86.66
37%
-83
- C1 -
3IL9
-
FABH_ECOLI
A:
[1-316]
-
M
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
N
E
T
V
S
T
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
-
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
S
E
E
-
P
G
-
I
I
S
T
H
L
H
A
D
G
S
-
Y
G
-
E
L
------
L
T
-
L
P
N
-
A
D
R
V
N
P
E
N
SI
H
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
S
M
D
N
V
V
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
D
G
R
I
K
--
P
G
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
55
HHSearch
86.55
41%
-95
* C1 *
2EBD
-
FABH_AQUAE
A:
[1-309]
-
M
G
T
K
I
I
G
T
G
V
Y
L
P
K
N
V
L
T
N
F
D
L
E
K
I
V
D
T
S
D
E
W
I
T
T
R
T
G
I
K
E
R
R
I
A
-
K
E
E
T
I
T
Y
M
A
T
Q
A
A
K
E
A
L
R
E
A
N
L
S
P
E
E
L
D
L
I
I
L
A
T
L
T
P
Q
K
R
F
P
S
T
A
C
L
V
Q
A
Q
L
K
A
K
G
V
Y
A
F
D
I
S
A
A
C
S
G
F
I
Y
A
L
D
I
A
D
S
F
I
K
S
G
K
A
K
N
V
L
V
I
G
A
E
K
L
S
E
A
V
D
W
E
D
R
S
T
C
V
L
F
G
D
G
A
G
A
V
V
V
T
R
S
E
D
K
S
D
-
I
L
A
T
R
M
Y
A
E
G
S
-
L
E
E
L
L
H
A
D
N
C
---------------
G
--
Y
I
R
M
K
G
R
E
L
F
K
V
A
V
R
S
M
E
E
V
C
R
E
V
L
E
K
A
G
V
K
P
E
E
V
S
L
V
I
P
H
Q
A
N
V
R
I
I
N
A
L
A
E
K
L
N
I
P
K
E
K
V
F
V
-
N
I
Q
K
Y
G
N
T
S
A
A
S
I
P
I
A
L
H
E
A
I
K
E
G
K
V
K
--
R
G
D
L
I
L
M
T
A
M
G
G
G
L
T
W
G
A
V
L
L
R
Y
18
PsiBlast_PDB
86.40
37%
-87
- C1 -
1EBL
1
FABH_ECOLI
A:
[2-316]
--
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
N
E
T
V
S
T
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
S
E
E
-
P
G
-
I
I
S
T
H
L
H
A
D
G
S
-
Y
G
-
E
L
------
L
T
-
L
P
N
-
A
D
R
V
N
P
E
N
SI
H
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
N
D
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
S
M
D
N
V
V
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
D
G
R
I
K
--
P
G
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
37
PsiBlast_CBE
86.38
39%
-81
- C1 -
1UB7
3
?
B:
[4-317]
-----
I
L
A
L
G
A
Y
V
P
E
R
V
M
T
N
A
D
F
E
A
Y
L
D
T
S
D
E
W
I
V
T
R
T
G
I
K
E
R
R
V
A
A
E
D
E
Y
T
S
D
L
A
F
K
A
V
E
D
L
L
R
R
H
P
G
A
L
E
G
V
D
A
V
I
V
A
T
N
T
P
D
A
L
F
P
D
T
A
A
L
V
Q
A
R
F
G
L
-
K
A
F
A
Y
D
L
L
A
G
C
P
G
W
I
Y
A
L
A
Q
A
H
A
L
V
E
A
G
L
A
Q
K
V
L
A
V
G
A
E
A
L
S
K
I
I
D
W
N
D
R
A
T
A
V
L
F
G
D
G
G
G
A
A
V
V
G
K
V
R
E
-
G
Y
G
F
R
S
F
V
L
G
A
D
G
T
G
A
K
-
E
L
Y
H
A
C
V
A
P
R
-
L
P
---
D
G
T
S
M
K
N
--
R
L
Y
M
N
G
R
E
V
F
K
F
A
V
R
V
M
N
T
A
T
L
E
A
I
E
K
A
G
L
T
P
E
D
I
R
L
F
V
P
H
Q
A
N
L
R
I
I
D
A
A
R
E
R
L
G
L
P
W
E
R
V
A
V
-
N
V
D
R
Y
G
N
T
S
T
A
S
I
P
L
A
L
K
E
A
V
D
A
G
R
I
R
-
E
G
D
H
V
L
L
V
S
-
F
G
A
G
L
T
W
A
A
A
V
L
T
W
45
HHSearch
86.31
38%
-86
- C1 -
1HNJ
2
FABH_ECOLI
A:
[1-317]
-
M
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
N
E
T
V
S
T
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
S
E
E
-
P
G
-
I
I
S
T
H
L
H
A
D
G
S
-
Y
G
E
L
L
T
L
P
N
A
D
R
V
-
N
P
------
E
N
S
I
--
H
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
S
M
D
N
V
V
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
D
G
R
I
K
--
P
G
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
11
PsiBlast_PDB
86.28
37%
-88
- C1 -
2EFT
3
FABH_ECOLI
A:
[1-316]
-
M
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
N
E
T
V
S
T
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
S
E
E
-
P
G
-
I
I
S
T
H
L
H
A
D
G
S
-
Y
G
-
E
L
------
L
T
-
L
P
N
-
A
D
R
V
N
P
E
N
SI
H
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
S
M
D
N
V
V
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
D
G
R
I
K
--
P
G
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
12
PsiBlast_PDB
85.97
37%
-86
- C1 -
2GYO
3
FABH_ECOLI
A:
[1-316]
-
M
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
N
E
T
V
S
T
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
S
E
E
-
P
G
-
I
I
S
T
H
L
H
A
D
G
S
-
Y
G
-
E
L
------
L
T
-
L
P
N
-
A
D
R
V
N
P
E
N
SI
H
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
S
M
D
N
V
V
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
D
G
R
I
K
--
P
G
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
36
PsiBlast_CBE
85.82
39%
-82
- C1 -
1UB7
4
?
C:
[4-317]
-----
I
L
A
L
G
A
Y
V
P
E
R
V
M
T
N
A
D
F
E
A
Y
L
D
T
S
D
E
W
I
V
T
R
T
G
I
K
E
R
R
V
A
A
E
D
E
Y
T
S
D
L
A
F
K
A
V
E
D
L
L
R
R
H
P
G
A
L
E
G
V
D
A
V
I
V
A
T
N
T
P
D
A
L
F
P
D
T
A
A
L
V
Q
A
R
F
G
L
-
K
A
F
A
Y
D
L
L
A
G
C
P
G
W
I
Y
A
L
A
Q
A
H
A
L
V
E
A
G
L
A
Q
K
V
L
A
V
G
A
E
A
L
S
K
I
I
D
W
N
D
R
A
T
A
V
L
F
G
D
G
G
G
A
A
V
V
G
K
V
R
E
-
G
Y
G
F
R
S
F
V
L
G
A
D
G
T
G
A
K
-
E
L
Y
H
A
C
V
A
P
R
-
L
P
---
D
G
T
S
M
K
N
--
R
L
Y
M
N
G
R
E
V
F
K
F
A
V
R
V
M
N
T
A
T
L
E
A
I
E
K
A
G
L
T
P
E
D
I
R
L
F
V
P
H
Q
A
N
L
R
I
I
D
A
A
R
E
R
L
G
L
P
W
E
R
V
A
V
-
N
V
D
R
Y
G
N
T
S
T
A
S
I
P
L
A
L
K
E
A
V
D
A
G
R
I
R
-
E
G
D
H
V
L
L
V
S
-
F
G
A
G
L
T
W
A
A
A
V
L
T
W
3
PsiBlast_PDB
85.67
40%
-94
- C1 -
2EBD
-
FABH_AQUAE
A:
[4-308]
----
K
I
I
G
T
G
V
Y
L
P
K
N
V
L
T
N
F
D
L
E
K
I
V
D
T
S
D
E
W
I
T
T
R
T
G
I
K
E
R
R
I
A
-
K
E
E
T
I
T
Y
M
A
T
Q
A
A
K
E
A
L
R
E
A
N
L
S
P
E
E
L
D
L
I
I
L
A
T
L
T
P
Q
K
R
F
P
S
T
A
C
L
V
Q
A
Q
L
K
A
K
G
V
Y
A
F
D
I
S
A
A
C
S
G
F
I
Y
A
L
D
I
A
D
S
F
I
K
S
G
K
A
K
N
V
L
V
I
G
A
E
K
L
S
E
A
V
D
W
E
D
R
S
T
C
V
L
F
G
D
G
A
G
A
V
V
V
T
R
S
E
D
-
K
S
D
I
L
A
T
R
M
Y
A
E
G
S
L
E
E
-
L
L
H
A
D
N
C
G
-----------------
Y
I
R
M
K
G
R
E
L
F
K
V
A
V
R
S
M
E
E
V
C
R
E
V
L
E
K
A
G
V
K
P
E
E
V
S
L
V
I
P
H
Q
A
N
V
R
I
I
N
A
L
A
E
K
L
N
I
P
K
E
K
V
F
V
-
N
I
Q
K
Y
G
N
T
S
A
A
S
I
P
I
A
L
H
E
A
I
K
E
G
--
K
V
K
R
G
D
L
I
L
M
T
A
M
G
G
G
L
T
W
G
A
V
L
L
R
Y
33
PsiBlast_CBE
85.64
37%
-86
- C1 -
1HN9
1
FABH_ECOLI
B:
[1-316]
-
M
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
N
E
T
V
S
T
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
S
E
E
-
P
G
-
I
I
S
T
H
L
H
A
D
G
S
-
Y
G
-
E
L
------
L
T
-
L
P
N
-
A
D
R
V
N
P
E
N
SI
H
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
S
M
D
N
V
V
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
D
G
R
I
K
--
P
G
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
50
HHSearch
78.42
30%
-75
- C1 -
1MZJ
2
FABH_STRLI
A:
[9-331]
R
R
F
S
R
V
L
G
V
G
S
Y
R
P
R
R
E
V
S
N
K
E
V
C
T
W
I
D
S
T
E
E
W
I
E
T
R
T
G
I
R
S
R
R
I
A
E
P
D
E
T
I
Q
V
M
G
V
A
A
S
R
R
A
L
E
H
A
G
V
D
P
A
E
I
D
L
V
V
V
S
T
M
T
N
F
V
H
T
P
P
L
S
V
A
I
A
H
E
L
G
A
D
N
A
G
G
F
D
L
S
A
A
C
A
G
F
C
H
A
L
S
I
A
A
D
A
V
E
S
G
G
S
R
H
V
L
V
V
A
T
E
R
M
T
D
V
I
D
L
A
D
R
S
L
S
F
L
F
G
D
G
A
G
A
A
V
V
G
P
S
D
V
-
P
G
-
I
G
P
V
V
R
G
I
D
G
T
-
G
L
G
S
L
H
M
S
S
S
W
D
Q
-
Y
V
E
--
D
P
S
V
G
R
P
--
A
L
V
M
D
G
K
R
V
F
R
W
A
V
A
D
V
V
P
A
A
R
E
A
L
E
V
A
G
L
T
V
G
D
L
V
A
F
V
P
H
Q
A
N
L
R
I
I
D
V
L
V
D
R
L
G
V
P
E
H
V
V
V
S
R
D
A
E
D
T
G
N
T
S
S
A
S
V
A
L
A
L
D
R
L
V
R
S
G
A
V
P
--
G
G
G
P
A
L
M
I
G
F
G
A
G
L
S
Y
A
G
Q
A
L
L
L