@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0572: (2015-12-02 )
MSKKLISIVDVKDYVGQEVTIGAWVANKSGKGKIAFVQLRDGSAFFQGVAFKPNFIEKYGEESGLEKFDVIKRLNQETSVYVTGIVKEDERSKFGYELDITDLEVIGESHEYPITPKEHGTDFLMDNRHLWLRSRKQMAVMQIRNAIIYSTYEFFDQNGFIKFDSPILSENAAEDSTELFETDYFGKPAFLSQSGQLYLEAGAMALGRVFDFGPVFRAEKSKTRRHLTEFWMMDAEYSFLSHEESLDLQEAYVKALIQGVLDRAPQALDILERDVEALKRYIAEPFKRVSYDDAITLLQEHEADEDTDYEHLEHGDDFGSPHETWISNYFGVPTFVVNYPASFKAFYMKPVPGNPERVLCADLLAPEGYGEIIGGSMREDDYDALVAKMDELGMDKSEYDFYLDLRKYGSVPHGGFGIGIERMVTFVAGTKHIREAIPFPRMLHRIKP
Atome Classification :
(26 SA)
---------.........10.-..-....---.20......-..30.-.-......40........50........60........70.---.......80.......--------.90----.---.--------.---..----....100.....-------------.-.110...-----..---.---------------------------..---------------120---.........130.......140.......150.......160.......170.......180.......190.......200.-...-....210.......220.......230.......240-.-.......250.......260-......--..270....--...280.....--------..290.......--300.-......310..------.....320...----....330--.-.-----..-....-.340.......350.......360.......370........380.......390....-----...400-........410.......420.......430.......440......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------MSK
K
L
I
S
I
V
D
V
K
-
D
Y-VGQE---
V
T
I
G
A
W
V
AN-KSGKG-
K
-
I
A
F
V
Q
LRDG
S
A
F
F
QGVAFK
P
N
F
I
E
K
Y
G
E
ESG
L
E
K
F
D
V
I
K
---
R
LNQET
S
V
Y
V
T
G
I
VKE--------DE-----R---S--------K---FG----
Y
E
L
DI
T
D
L
E
V
IG-------------E-SHE-YPI-----TP---K---------------------------EH---------------G-----TDFLMDN
R
H
L
W
L
R
S
R
K
Q
M
A
V
M
Q
I
R
N
A
I
I
Y
S
T
Y
E
F
FDQNG
F
I
KFDSPILSENAAED
S
T
E
L
FETDYFGKPAFLSQS
G
Q
L
Y
L
E
-
A
G
-
A
M
A
-
L
G
R
VFDFGPVFR
A
E
K
S
K
T
R
R
H
L
T
E
F
W
MMDA
E
Y
S
FL-S-H-EESL
D
L
Q
E
A
Y
V
K
A
L
I
Q
G
V
L
--DRA
P
Q
A
--
L
D
I
L
E
R
D
V
E
--
A
L
K
R
Y
I
A
E
P
F
K
--------RVS
Y
D
D
A
I
T
L
L
Q
--EHEA-DEDT
D
Y
E
H
LEH------GDDFG
S
P
H
E
T
W
----
I
S
NYF----G-V-----
P
T
-
F
V
V
N-YPAS
F
K
A
F
Y
M
KPVPGNPE
R
V
L
C
A
D
LLAPEG
Y
G
-
E
IIGGSMRE
D
D
Y
D
A
L
V
A
K
M
D
E
LGMDK-----SE
Y
D
F
--
Y
L
D
L
R
K
YGSVPHG
G
F
GI
G
I
E
R
M
V
T
F
V
AG
T
K
H
I
R
E
AI
P
F
P
R
M
L
H
RIKP
54
HHSearch
98.61
43%
-85
- C7 -
1X54
3
SYN_PYRHO
A:
[2-434]
-----------
I
E
K
V
Y
C
Q
E
V
K
-
P
E
L
D
G
K
K
---
V
R
L
A
G
W
V
Y
T
-
N
M
R
V
G
-
K
-
K
I
F
L
W
I
R
D
S
T
G
I
V
Q
A
V
V
A
K
N
V
--------
V
G
E
E
T
F
E
K
A
K
---
K
L
G
R
E
S
S
V
I
V
E
G
I
V
K
A
--------
D
E
-----
R
---
A
--------
P
---
G
G
----
A
E
V
H
V
E
K
L
E
V
I
Q
-------------
A
-
V
S
E
-
F
P
I
-----
P
E
NP-
E
---------------------------
Q
A
---------------
S
-----
P
E
L
L
L
D
Y
R
H
L
H
I
R
T
P
K
A
S
A
I
M
K
V
K
E
T
L
I
M
A
A
R
E
W
L
L
K
D
G
W
H
E
V
F
P
P
I
L
V
T
G
A
V
E
G
G
A
T
L
F
K
L
K
Y
F
D
K
Y
A
Y
L
S
Q
S
A
Q
L
Y
L
E
-
A
A
-
I
F
G
-
L
E
K
V
W
S
L
T
P
S
F
R
A
E
K
S
R
T
R
R
H
L
T
E
F
W
H
L
E
L
E
A
A
W
M
-
D
-
L
-
W
D
I
M
K
V
E
E
E
L
V
S
Y
M
V
Q
R
T
L
--
E
L
R
K
K
E
--
I
E
M
F
R
D
D
L
T
--
T
L
-
K
N
T
E
P
P
F
P
--------
R
I
S
Y
D
E
A
I
D
I
L
Q
--
S
K
G
-------
V
N
V
-
E
W
------
G
D
D
L
G
A
D
E
E
R
V
----
L
T
E
E
F
----
D
-
R
-----
P
F
-
F
V
Y
G
-
Y
P
K
H
I
K
A
F
Y
M
K
E
D
P
N
D
P
R
K
V
L
A
S
D
M
L
A
P
E
G
Y
G
-
E
I
I
G
G
S
Q
R
E
D
D
Y
D
K
L
L
N
R
I
L
E
E
G
M
D
P
-----
K
D
Y
E
W
--
Y
L
D
L
R
R
Y
G
S
V
P
H
S
G
F
G
L
G
V
E
R
L
V
A
W
V
L
K
L
D
H
I
R
W
A
A
L
F
P
R
T
P
A
R
L
Y
P
2
PsiBlast_PDB
98.10
42%
-85
- C7 -
1X55
4
SYN_PYRHO
A:
[16-434]
--------------------------
G
K
K
---
V
R
L
A
G
W
V
Y
T
-
N
M
R
V
G
-
K
-
K
I
F
L
W
I
R
D
S
T
G
I
V
Q
A
V
V
A
K
-
N
V
V
-------
G
E
E
T
F
E
K
A
K
---
K
L
G
R
E
S
S
V
I
V
E
G
I
V
K
A
--------
D
E
-----
R
---
A
--------
P
---
G
G
----
A
E
V
H
V
E
K
L
E
V
I
Q
-------------
A
-
V
S
E
-
F
P
I
PE---
N
P
---
E
---------------------------
Q
A
---------------
S
-----
P
E
L
L
L
D
Y
R
H
L
H
I
R
T
P
K
A
S
A
I
M
K
V
K
E
T
L
I
M
A
A
R
E
W
L
L
K
D
G
W
H
E
V
F
P
P
I
L
V
T
G
A
V
E
G
G
A
T
L
F
K
L
K
Y
F
D
K
Y
A
Y
L
S
Q
S
A
Q
L
Y
L
E
-
A
A
-
I
F
G
-
L
E
K
V
W
S
L
T
P
S
F
R
A
E
K
S
R
T
R
R
H
L
T
E
F
W
H
L
E
L
E
A
A
W
M
-
D
-
L
-
W
D
I
M
K
V
E
E
E
L
V
S
Y
M
V
Q
R
T
L
--
E
L
R
K
K
E
--
I
E
M
F
R
D
D
L
T
--
T
L
K
N
-
T
E
P
P
F
P
--------
R
I
S
Y
D
E
A
I
D
I
L
Q
--
S
K
G
V
-
N
-------
V
E
W
------
G
D
D
L
G
A
D
E
E
R
V
----
L
T
E
E
F
----
D
-
R
-----
P
F
-
F
V
Y
G
-
Y
P
K
H
I
K
A
F
Y
M
K
E
D
P
N
D
P
R
K
V
L
A
S
D
M
L
A
P
E
G
Y
G
-
E
I
I
G
G
S
Q
R
E
D
D
Y
D
K
L
L
N
R
I
L
E
E
G
M
D
P
-----
K
D
Y
E
W
--
Y
L
D
L
R
R
Y
G
S
V
P
H
S
G
F
G
L
G
V
E
R
L
V
A
W
V
L
K
L
D
H
I
R
W
A
A
L
F
P
R
T
P
A
R
L
Y
P
1
PsiBlast_PDB
97.80
42%
-87
- C7 -
1X54
3
SYN_PYRHO
A:
[16-434]
--------------------------
G
K
K
---
V
R
L
A
G
W
V
Y
T
-
N
M
R
V
G
-
K
-
K
I
F
L
W
I
R
D
S
T
G
I
V
Q
A
V
V
A
K
-
N
V
V
-------
G
E
E
T
F
E
K
A
K
---
K
L
G
R
E
S
S
V
I
V
E
G
I
V
K
A
--------
D
E
-----
R
---
A
--------
P
---
G
G
----
A
E
V
H
V
E
K
L
E
V
I
Q
-------------
A
-
V
S
E
-
F
P
I
PE---
N
P
---
E
---------------------------
Q
A
---------------
S
-----
P
E
L
L
L
D
Y
R
H
L
H
I
R
T
P
K
A
S
A
I
M
K
V
K
E
T
L
I
M
A
A
R
E
W
L
L
K
D
G
W
H
E
V
F
P
P
I
L
V
T
G
A
V
E
G
G
A
T
L
F
K
L
K
Y
F
D
K
Y
A
Y
L
S
Q
S
A
Q
L
Y
L
E
-
A
A
-
I
F
G
-
L
E
K
V
W
S
L
T
P
S
F
R
A
E
K
S
R
T
R
R
H
L
T
E
F
W
H
L
E
L
E
A
A
W
M
-
D
-
L
-
W
D
I
M
K
V
E
E
E
L
V
S
Y
M
V
Q
R
T
L
--
E
L
R
K
K
E
--
I
E
M
F
R
D
D
L
T
--
T
L
K
N
-
T
E
P
P
F
P
--------
R
I
S
Y
D
E
A
I
D
I
L
Q
--
S
K
G
V
-
N
-------
V
E
W
------
G
D
D
L
G
A
D
E
E
R
V
----
L
T
E
E
F
----
D
-
R
-----
P
F
-
F
V
Y
G
-
Y
P
K
H
I
K
A
F
Y
M
K
E
D
P
N
D
P
R
K
V
L
A
S
D
M
L
A
P
E
G
Y
G
-
E
I
I
G
G
S
Q
R
E
D
D
Y
D
K
L
L
N
R
I
L
E
E
G
M
D
P
-----
K
D
Y
E
W
--
Y
L
D
L
R
R
Y
G
S
V
P
H
S
G
F
G
L
G
V
E
R
L
V
A
W
V
L
K
L
D
H
I
R
W
A
A
L
F
P
R
T
P
A
R
L
Y
P
3
PsiBlast_PDB
97.63
42%
-97
- C7 -
1X56
-
SYN_PYRHO
A:
[16-434]
--------------------------
G
K
K
---
V
R
L
A
G
W
V
Y
T
-
N
M
R
V
G
-
K
-
K
I
F
L
W
I
R
D
S
T
G
I
V
Q
A
V
V
A
K
-
N
V
V
-------
G
E
E
T
F
E
K
A
K
---
K
L
G
R
E
S
S
V
I
V
E
G
I
V
K
A
--------
D
E
-----
R
---
A
--------
P
---
G
G
----
A
E
V
H
V
E
K
L
E
V
I
Q
-------------
A
-
V
S
E
-
F
P
I
PE---
N
P
---
E
---------------------------
Q
A
---------------
S
-----
P
E
L
L
L
D
Y
R
H
L
H
I
R
T
P
K
A
S
A
I
M
K
V
K
E
T
L
I
M
A
A
R
E
W
L
L
K
D
G
W
H
E
V
F
P
P
I
L
V
T
--------
L
F
K
L
K
Y
F
D
K
Y
A
Y
L
S
Q
S
A
Q
L
Y
L
E
-
A
A
-
I
F
G
-
L
E
K
V
W
S
L
T
P
S
F
R
A
E
------
H
L
T
E
F
W
H
L
E
L
E
A
A
W
M
-
D
-
L
-
W
D
I
M
K
V
E
E
E
L
V
S
Y
M
V
Q
R
T
L
--
E
L
R
K
K
E
--
I
E
M
F
R
D
D
L
T
--
T
L
K
N
-
T
E
P
P
F
P
--------
R
I
S
Y
D
E
A
I
D
I
L
Q
--
S
K
G
V
-
N
-------
V
E
W
------
G
D
D
L
G
A
D
E
E
R
V
----
L
T
E
E
F
----
D
-
R
-----
P
F
-
F
V
Y
G
-
Y
P
K
H
I
K
A
F
Y
M
K
E
D
P
N
D
P
R
K
V
L
A
S
D
M
L
A
P
E
G
Y
G
-
E
I
I
G
G
S
Q
R
E
D
D
Y
D
K
L
L
N
R
I
L
E
E
G
M
D
P
-----
K
D
Y
E
W
--
Y
L
D
L
R
R
Y
G
S
V
P
H
S
G
F
G
L
G
V
E
R
L
V
A
W
V
L
K
L
D
H
I
R
W
A
A
L
F
P
R
T
P
A
R
L
Y
P
53
HHSearch
91.40
32%
-80
* C7 *
1WYD
3
SYDND_SULTO
A:
[2-429]
-----------
Y
R
S
H
F
I
A
D
V
T
-
P
E
Y
D
G
K
E
---
V
I
W
A
G
W
V
H
L
-
L
R
D
L
G
-
G
-
K
K
F
I
I
L
R
D
K
T
G
L
G
Q
V
V
V
D
K
N
S
-----------
S
A
F
G
I
S
Q
---
E
L
T
Q
E
S
V
I
Q
V
R
G
I
V
K
A
--------
D
K
-----
R
---
A
--------
P
---
R
G
----
I
E
L
H
A
E
E
I
T
L
L
S
-------------
K
A
K
A
P
-
L
P
L
-----
D
V
---
S
GKV------------------------
K
A
---------------
D
-----
I
D
T
R
L
R
E
R
V
L
D
L
R
R
Q
E
M
Q
A
V
I
K
I
Q
S
L
A
L
K
A
F
R
E
T
L
Y
K
E
G
F
I
E
I
F
T
P
K
I
I
A
S
A
T
E
G
G
A
Q
L
F
P
V
I
Y
F
G
K
E
A
F
L
A
Q
S
P
Q
L
Y
K
E
-
L
M
-
A
G
V
-
V
E
R
V
F
E
V
A
P
A
W
R
A
E
E
S
D
T
P
F
H
L
A
E
F
I
S
M
D
V
E
M
A
F
A
-
D
-
Y
-
N
D
V
M
Q
L
L
E
K
I
L
H
N
I
V
K
T
I
K
--
E
E
G
K
E
E
--
L
K
I
L
N
Y
E
P
------
P
E
V
K
I
P
I
K
--------
R
L
K
Y
T
E
A
I
E
I
L
R
--
S
K
G
-------
Y
N
I
-
K
F
------
G
D
D
I
G
T
P
E
L
R
I
----
L
N
E
E
L
----
K
E
D
-----
L
Y
-
F
I
V
D
-
W
P
S
D
A
R
P
F
Y
T
K
S
K
S
E
-
P
E
L
S
E
S
F
D
L
I
Y
K
-
F
L
--
E
I
V
S
G
S
T
R
N
H
K
R
E
V
L
E
E
A
L
K
K
K
G
L
K
P
-----
E
S
F
E
F
--
F
L
K
W
F
D
Y
G
M
P
P
H
A
G
F
G
M
G
L
A
R
L
M
V
M
L
T
G
I
Q
S
V
K
E
I
V
P
F
P
R
D
K
K
R
L
T
P
21
PsiBlast_CBE
90.22
33%
-85
- C7 -
3M4P
5
?
D:
[19-456]
----------------
V
C
N
I
R
-
D
A
-
A
G
L
E
GKL
V
T
F
K
G
W
A
Y
H
I
R
K
A
R
K
-
T
-
L
I
F
V
E
L
R
D
G
S
G
Y
C
Q
C
V
I
F
G
K
E
L
C
E
P
----------
E
K
V
K
---
L
L
T
R
E
C
S
L
E
I
T
G
R
L
N
A
YAGKNHPP
E
I
-----
A
---
D
--------
I
---
L
N
----
L
E
M
Q
V
T
E
W
K
V
I
G
-------------
E
-
S
----
P
I
DLENI
I
N
---
K
---------------------------
D
S
---------------
S
-----
I
P
Q
K
M
Q
N
R
H
I
V
I
R
S
E
H
T
Q
Q
V
L
Q
L
R
S
E
I
Q
W
Y
F
R
K
Y
Y
H
D
N
H
F
T
E
I
Q
P
P
T
I
V
K
T
------
T
L
F
K
L
Q
Y
F
N
E
P
A
Y
L
T
Q
S
S
Q
L
Y
L
E
-
S
V
-
I
A
S
-
L
G
K
S
F
C
M
L
S
S
Y
R
A
E
Q
S
R
T
V
R
H
L
A
E
Y
L
H
L
E
A
E
L
P
F
I
-
S
-
F
-
E
D
L
L
N
H
L
E
D
L
V
C
T
V
I
D
N
V
M
--
A
V
H
G
D
K
--
I
----
R
K
M
N
--
P
H
L
K
L
P
T
R
P
F
K
--------
R
M
T
Y
A
D
A
I
K
Y
C
N
--
D
H
G
I
L
N
K
D
K
P
F
---
E
Y
------
G
E
D
I
S
E
K
P
E
R
Q
----
M
T
D
E
I
----
G
-
C
-----
P
I
-
F
M
I
H
-
F
P
S
K
M
K
A
F
Y
M
S
K
V
P
G
H
P
D
L
T
E
S
V
D
L
L
M
P
-
G
V
G
-
E
I
V
G
G
S
M
R
I
W
N
Y
D
E
L
M
G
A
Y
K
A
N
G
L
N
P
-----
D
P
Y
Y
W
--
Y
T
Q
Q
R
K
Y
G
S
C
P
H
G
G
Y
G
L
G
V
E
R
L
V
M
W
L
L
G
E
D
H
I
R
K
V
C
L
Y
P
R
Y
L
E
R
C
E
P
55
HHSearch
89.75
35%
-82
- C7 -
3M4P
5
?
A:
[20-456]
--------------
C
N
I
R
D
A
A
-
G
L
-
E
G
K
L
---
V
T
F
K
G
W
A
Y
H
-
I
R
K
A
R
K
T
-
L
I
F
V
E
L
R
D
G
S
G
Y
C
Q
C
V
I
F
G
K
E
--------
L
--
C
E
P
E
K
V
K
---
L
L
T
R
E
C
S
L
E
I
T
G
R
L
N
A
--------
Y
A
-----
G
---
K
NHPPEIAD
I
---
L
N
----
L
E
M
Q
V
T
E
W
K
V
I
G
-------------
E
S
P
I
D
-
L
E
N
-----
I
I
N--
K
---------------------------
D
S
---------------
S
-----
I
P
Q
K
M
Q
N
R
H
I
V
I
R
S
E
H
T
Q
Q
V
L
Q
L
R
S
E
I
Q
W
Y
F
R
K
Y
Y
H
D
N
H
F
T
E
I
Q
P
P
T
I
V
K
------
S
T
L
F
K
L
Q
Y
F
N
E
P
A
Y
L
T
Q
S
S
Q
L
Y
L
E
-
S
V
-
I
A
S
-
L
G
K
S
F
C
M
L
S
S
Y
R
A
E
Q
S
R
T
V
R
H
L
A
E
Y
L
H
L
E
A
E
L
P
F
I
-
S
-
F
-
E
D
L
L
N
H
L
E
D
L
V
C
T
V
I
D
N
V
M
--
A
V
H
G
D
K
--
I
R
K
M
N
P
H
L
------
K
L
P
T
R
P
F
K
--------
R
M
T
Y
A
D
A
I
K
Y
C
N
--
D
H
G
I
-
L
N
K
-
D
K
P
F
-
E
Y
------
G
E
D
I
S
E
K
P
E
R
Q
----
M
T
D
E
I
----
G
-
C
-----
P
I
-
F
M
I
H
-
F
P
S
K
M
K
A
F
Y
M
S
K
V
P
G
H
P
D
L
T
E
S
V
D
L
L
M
P
-
G
V
G
-
E
I
V
G
G
S
M
R
I
W
N
Y
D
E
L
M
G
A
Y
K
A
N
G
L
N
P
-----
D
P
Y
Y
W
--
Y
T
Q
Q
R
K
Y
G
S
C
P
H
G
G
Y
G
L
G
V
E
R
L
V
M
W
L
L
G
E
D
H
I
R
K
V
C
L
Y
P
R
Y
L
E
R
C
E
P
22
PsiBlast_CBE
89.57
33%
-92
- C7 -
3M4P
5
?
C:
[19-456]
----------------
V
C
N
I
R
-
D
A
-
A
G
L
E
GKL
V
T
F
K
G
W
A
Y
H
I
R
K
A
R
K
-
T
-
L
I
F
V
E
L
R
D
G
S
G
Y
C
Q
C
V
I
F
G
K
E
L
C
E
P
----------
E
K
V
K
---
L
L
T
R
E
C
S
L
E
I
T
G
R
L
N
A
YAGKNHPP
E
I
-----
A
---
D
--------
I
---
L
N
----
L
E
M
Q
V
T
E
W
K
V
I
G
-------------
E
-
S
----
P
I
DLENI
I
N
---
K
---------------------------
D
S
---------------
S
-----
I
P
Q
K
M
Q
N
R
H
I
V
I
R
S
E
H
T
Q
Q
V
L
Q
L
R
S
E
I
Q
W
Y
F
R
K
Y
Y
H
D
N
H
F
T
E
I
Q
P
P
T
I
V
K
-------
T
L
F
K
L
Q
Y
F
N
E
P
A
Y
L
T
Q
S
S
Q
L
Y
L
E
-
S
V
-
I
A
S
-
L
G
K
S
F
C
M
L
S
S
Y
R
A
E
Q
S
R
T
V
R
H
L
A
E
Y
L
H
L
E
A
E
L
P
F
I
-
S
-
F
-
E
D
L
L
N
H
L
E
D
L
V
C
T
V
I
D
N
V
M
--
A
V
H
G
D
K
--
I
----
R
K
M
N
--
P
H
L
K
L
P
T
R
P
F
K
--------
R
M
T
Y
A
D
A
I
K
Y
C
N
--
D
H
-----
D
K
P
F
---
E
Y
------
G
E
D
I
S
E
K
P
E
R
Q
----
M
T
D
E
I
----
G
-
C
-----
P
I
-
F
M
I
H
-
F
P
S
K
M
K
A
F
Y
M
S
K
V
P
G
H
P
D
L
T
E
S
V
D
L
L
M
P
-
G
V
G
-
E
I
V
G
G
S
M
R
I
W
N
Y
D
E
L
M
G
A
Y
K
A
N
G
L
N
P
-----
D
P
Y
Y
W
--
Y
T
Q
Q
R
K
Y
G
S
C
P
H
G
G
Y
G
L
G
V
E
R
L
V
M
W
L
L
G
E
D
H
I
R
K
V
C
L
Y
P
R
Y
L
E
R
C
E
P
12
PsiBlast_PDB
89.47
30%
-79
- C7 -
1WYD
3
SYDND_SULTO
A:
[7-429]
----------------
I
A
D
V
T
P
E
Y
-
D
G
K
E
---
V
I
W
A
G
W
V
H
L
-
L
R
D
L
G
-
G
-
K
K
F
I
I
L
R
D
K
T
G
L
G
Q
V
V
V
D
K
N
S
-----------
S
A
F
G
I
S
Q
---
E
L
T
Q
E
S
V
I
Q
V
R
G
I
V
K
A
--------
D
K
-----
R
---
A
--------
P
---
R
G
----
I
E
L
H
A
E
E
I
T
L
L
S
-------------
K
-
A
-
K
-
A
P
L
-----
P
L
---
D
---------------------------
V
S
---------------
G
KVKAD
I
D
T
R
L
R
E
R
V
L
D
L
R
R
Q
E
M
Q
A
V
I
K
I
Q
S
L
A
L
K
A
F
R
E
T
L
Y
K
E
G
F
I
E
I
F
T
P
K
I
I
A
S
A
T
E
G
G
A
Q
L
F
P
V
I
Y
F
G
K
E
A
F
L
A
Q
S
P
Q
L
Y
K
E
-
L
M
-
A
G
V
-
V
E
R
V
F
E
V
A
P
A
W
R
A
E
E
S
D
T
P
F
H
L
A
E
F
I
S
M
D
V
E
M
A
F
A
-
D
-
Y
-
N
D
V
M
Q
L
L
E
K
I
L
H
N
I
V
K
T
I
K
--
E
E
G
K
E
E
--
L
K
I
L
N
Y
E
P
P
--
E
V
K
I
----
P
I
K
--------
R
L
K
Y
T
E
A
I
E
I
L
R
----------
S
K
G
Y
N
I
K
F
------
G
D
D
I
G
T
P
E
L
R
I
----
L
N
E
E
L
----
K
-
E
-----
D
L
Y
F
I
V
D
-
W
P
S
D
A
R
P
F
Y
T
K
S
K
S
E
-
P
E
L
S
E
S
F
D
L
I
Y
--
K
F
L
-
E
I
V
S
G
S
T
R
N
H
K
R
E
V
L
E
E
A
L
K
K
K
G
L
K
P
-----
E
S
F
E
F
--
F
L
K
W
F
D
Y
G
M
P
P
H
A
G
F
G
M
G
L
A
R
L
M
V
M
L
T
G
I
Q
S
V
K
E
I
V
P
F
P
R
D
K
K
R
L
T
P
7
PsiBlast_PDB
89.43
31%
-85
- C7 -
2XTI
4
?
A:
[3-437]
--------------
V
K
I
R
D
L
V
-
K
H
-
R
N
E
R
---
V
C
I
K
G
W
I
H
R
-
M
R
R
Q
G
-
K
S
L
M
F
F
I
L
R
D
G
T
G
F
L
Q
V
L
L
M
----------
D
K
L
C
Q
T
Y
D
A
L
T
----
V
N
T
E
C
T
V
E
I
Y
G
A
I
K
E
--------
V
--------------------EAP
N
G
----
H
E
L
I
A
D
F
W
K
I
I
G
-------------
N
-
A
P
P
-
G
G
I
D
N
V
--
L
N
---
E
---------------------------
E
A
---------------
S
-----
V
D
K
M
L
D
N
R
H
L
V
I
R
G
E
N
A
A
A
L
L
R
L
R
A
A
A
T
R
A
M
R
E
H
F
Y
N
A
G
Y
V
E
V
A
P
P
T
L
V
Q
T
Q
V
E
G
G
S
T
L
F
N
L
D
Y
F
G
E
Q
S
F
L
T
Q
S
S
Q
L
Y
L
E
-
T
C
-
I
P
T
-
L
G
D
V
F
C
I
A
Q
S
Y
R
A
E
K
S
R
T
R
R
H
L
A
E
Y
A
H
V
E
A
E
C
P
F
I
-
T
-
L
-
D
D
L
M
E
K
I
E
E
L
V
C
D
T
V
D
R
L
L
A
D
E
E
A
K
K
L
--
L
E
H
I
N
P
K
F
Q
--
P
P
E
R
----
P
F
L
--------
R
M
E
Y
K
D
A
I
K
W
L
Q
--
E
H
N
V
-
E
N
E
F
G
-
N
T
F
T
Y
------
G
E
D
I
A
E
A
A
E
R
F
----
M
T
D
T
I
----
N
-
K
-----
P
I
-
L
L
N
R
-
F
P
S
E
I
K
A
F
Y
M
Q
R
D
A
K
D
N
T
L
T
E
S
V
D
L
L
M
P
-
G
V
G
-
E
I
V
G
G
S
M
R
I
W
K
F
D
E
L
S
K
A
F
K
N
V
E
I
D
P
-----
K
P
Y
Y
W
--
Y
L
D
Q
R
L
Y
G
T
C
P
H
G
G
Y
G
L
G
L
E
R
F
I
C
W
L
T
N
T
N
H
I
R
D
V
C
L
Y
P
R
F
V
G
R
C
V
P
56
HHSearch
89.41
30%
-85
- C7 -
3I7F
-
?
A:
[45-544]
------------
K
Y
T
E
I
E
E
L
V
-
P
A
M
A
E
K
T
---
V
T
I
R
A
R
V
Q
A
-
V
R
G
K
G
-
N
-
M
V
F
L
F
L
R
K
G
I
Y
T
C
Q
A
L
V
M
K
S
E
T
-------
I
S
K
E
F
V
Q
F
C
Q
---
K
I
S
A
E
S
I
C
D
I
T
G
I
V
K
A
--------
V
E
KPIEK
A
---
T
--------
Q
---
Q
D
----
V
E
I
H
V
T
S
I
A
V
V
S
-------------
L
A
E
Y
P
-
L
P
M
-----
Q
I
---
E
D
L
T
FP
S
S
V
F
K
K
Q
E
E
D
IAKVKASA
Q
K
Y
V
K
V
---------------
S
-----
Q
D
T
R
L
D
N
R
M
L
D
L
R
T
V
T
N
I
A
I
F
R
I
Q
S
A
C
C
G
L
F
R
E
F
L
T
S
Q
K
F
V
E
I
H
T
P
K
L
I
-------------------
A
Y
L
A
Q
S
P
Q
L
Y
K
Q
-
M
A
I
M
G
D
-
F
R
K
V
F
E
V
G
P
V
F
R
A
E
N
S
N
T
R
R
H
L
T
E
F
E
G
L
D
I
E
M
E
I
V
E
N
-
Y
-
H
E
C
I
D
V
M
E
K
L
F
T
F
I
F
D
E
I
P
--
K
R
F
P
D
E
--
L
K
V
I
R
K
Q
Y
---
P
F
E
D
L
I
Y
R
P
F
L
--------
R
L
T
Y
K
E
A
I
E
M
L
R
--
A
S
G
-------
E
T
I
-
G
D
------
Y
D
D
F
T
T
P
Q
E
V
K
----
L
G
E
L
I
K
A
K
Y
N
T
D
-----
F
Y
-
I
L
D
K
-
F
P
A
A
I
R
P
F
Y
T
M
P
D
I
D
D
P
N
Y
S
N
S
Y
D
V
F
V
R
-
G
Q
--
E
I
T
S
G
A
Q
R
I
H
D
P
E
F
L
M
K
R
C
I
E
K
G
V
D
P
-----
A
T
L
K
D
--
Y
I
E
S
F
R
F
G
S
W
P
H
A
G
C
G
I
G
L
E
R
I
T
M
L
Y
L
G
I
P
N
I
R
K
V
T
L
F
P
R
D
P
I
R
L
N
P
24
PsiBlast_CBE
89.15
31%
-86
- C7 -
2XTI
4
?
B:
[3-437]
--------------
V
K
I
R
D
L
V
-
K
H
-
R
N
E
R
---
V
C
I
K
G
W
I
H
R
-
M
R
R
Q
G
-
K
S
L
M
F
F
I
L
R
D
G
T
G
F
L
Q
V
L
L
M
----------
D
K
L
C
Q
T
Y
D
A
L
T
----
V
N
T
E
C
T
V
E
I
Y
G
A
I
K
E
--------
V
P
-------------------AP-
N
G
----
H
E
L
I
A
D
F
W
K
I
I
G
-------------
N
-
A
P
P
-
G
G
I
D
N
V
--
L
N
---
E
---------------------------
E
A
---------------
S
-----
V
D
K
M
L
D
N
R
H
L
V
I
R
G
E
N
A
A
A
L
L
R
L
R
A
A
A
T
R
A
M
R
E
H
F
Y
N
A
G
Y
V
E
V
A
P
P
T
L
V
Q
T
Q
V
---
S
T
L
F
N
L
D
Y
F
G
E
Q
S
F
L
T
Q
S
S
Q
L
Y
L
E
-
T
C
-
I
P
T
-
L
G
D
V
F
C
I
A
Q
S
Y
R
A
E
K
S
R
T
R
R
H
L
A
E
Y
A
H
V
E
A
E
C
P
F
I
-
T
-
L
-
D
D
L
M
E
K
I
E
E
L
V
C
D
T
V
D
R
L
L
A
D
E
E
A
K
K
L
--
L
E
H
I
N
P
K
F
Q
--
P
P
E
R
----
P
F
L
--------
R
M
E
Y
K
D
A
I
K
W
L
Q
--
E
H
N
V
-
E
N
E
F
G
-
N
T
F
T
Y
------
G
E
D
I
A
E
A
A
E
R
F
----
M
T
D
T
I
----
N
-
K
-----
P
I
-
L
L
N
R
-
F
P
S
E
I
K
A
F
Y
M
Q
R
D
A
K
D
N
T
L
T
E
S
V
D
L
L
M
P
-
G
V
G
-
E
I
V
G
G
S
M
R
I
W
K
F
D
E
L
S
K
A
F
K
N
V
E
I
D
P
-----
K
P
Y
Y
W
--
Y
L
D
Q
R
L
Y
G
T
C
P
H
G
G
Y
G
L
G
L
E
R
F
I
C
W
L
T
N
T
N
H
I
R
D
V
C
L
Y
P
R
F
V
G
R
C
V
P
23
PsiBlast_CBE
89.14
33%
-86
- C7 -
3M4P
5
?
B:
[19-456]
----------------
V
C
N
I
R
-
D
A
-
A
G
L
E
G
K
L
V
T
F
K
G
W
A
Y
H
I
R
K
A
R
K
-
T
-
L
I
F
V
E
L
R
D
G
S
G
Y
C
Q
C
V
I
F
G
K
E
L
C
E
P
----------
E
K
V
K
---
L
L
T
R
E
C
S
L
E
I
T
G
R
L
N
A
YAGK
N
H
P
P
E
I
-----
A
---
D
--------
I
---
L
N
----
L
E
M
Q
V
T
E
W
K
V
I
G
-------------
E
-
S
----
P
I
DLENI
I
N
---
K
---------------------------
D
S
---------------
S
-----
I
P
Q
K
M
Q
N
R
H
I
V
I
R
S
E
H
T
Q
Q
V
L
Q
L
R
S
E
I
Q
W
Y
F
R
K
Y
Y
H
D
N
H
F
T
E
I
Q
P
P
T
I
V
K
T
------
T
L
F
K
L
Q
Y
F
N
E
P
A
Y
L
T
Q
S
S
Q
L
Y
L
E
-
S
V
-
I
A
S
-
L
G
K
S
F
C
M
L
S
S
Y
R
A
E
Q
S
R
T
V
R
H
L
A
E
Y
L
H
L
E
A
E
L
P
F
I
-
S
-
F
-
E
D
L
L
N
H
L
E
D
L
V
C
T
V
I
D
N
V
M
--
A
V
H
G
D
K
--
I
----
R
K
M
N
--
P
H
L
K
L
P
T
R
P
F
K
--------
R
M
T
Y
A
D
A
I
K
Y
C
N
--
D
H
G
I
L
N
K
D
K
P
F
---
E
Y
------
G
E
D
I
S
E
K
P
E
R
Q
----
M
T
D
E
I
----
G
-
C
-----
P
I
-
F
M
I
H
-
F
P
S
K
M
K
A
F
Y
M
S
K
V
P
G
H
P
D
L
T
E
S
V
D
L
L
M
P
-
G
V
G
-
E
I
V
G
G
S
M
R
I
W
N
Y
D
E
L
M
G
A
Y
K
A
N
G
L
N
P
-----
D
P
Y
Y
W
--
Y
T
Q
Q
R
K
Y
G
S
C
P
H
G
G
Y
G
L
G
V
E
R
L
V
M
W
L
L
G
E
D
H
I
R
K
V
C
L
Y
P
R
Y
L
E
R
C
E
P
57
HHSearch
89.00
35%
-80
- C7 -
3NEM
1
SYD_THEKO
A:
[2-438]
-----------
Y
R
T
H
Y
S
S
E
I
T
-
E
E
L
N
G
Q
K
---
V
K
V
A
G
W
V
W
E
-
V
K
D
L
G
-
G
-
I
K
F
L
W
I
R
D
R
D
G
I
V
Q
I
T
A
P
K
K
K
--------
V
D
P
E
L
F
K
L
I
P
---
K
L
R
S
E
D
V
V
A
V
E
G
V
V
N
F
--------
T
P
-----
K
---
A
--------
K
---
L
G
----
F
E
I
L
P
E
K
I
V
V
L
N
-------------
R
A
E
T
P
-
L
P
L
-----
D
P
---
T
GK
V
------------------------
K
A
---------------
E
-----
L
D
T
R
L
D
N
R
F
M
D
L
R
R
P
E
V
M
A
I
F
K
I
R
S
S
V
F
K
A
V
R
D
F
F
H
E
N
G
F
I
E
I
H
T
P
K
I
I
A
T
A
T
E
G
G
T
E
L
F
P
M
K
Y
F
E
E
D
A
F
L
A
Q
S
P
Q
L
Y
K
Q
-
I
M
M
A
S
G
-
L
D
R
V
Y
E
I
A
P
I
F
R
A
E
E
H
N
T
T
R
H
L
N
E
A
W
S
I
D
S
E
M
A
F
I
E
D
-
E
-
E
E
V
M
S
F
L
E
R
L
V
A
H
A
I
N
Y
V
R
--
E
H
N
A
K
E
--
L
D
I
L
N
F
E
L
E
------
E
P
K
L
P
F
P
--------
R
V
S
Y
D
K
A
L
E
I
L
G
--
D
L
G
-------
K
E
I
-
P
W
------
G
E
D
I
D
T
E
G
E
R
L
----
L
G
K
Y
M
M
E
NE
N
A
P
-----
L
Y
-
F
L
Y
Q
-
Y
P
S
E
A
K
P
F
Y
I
M
K
Y
D
N
K
P
E
I
C
R
A
F
D
L
E
Y
R
-
G
V
--
E
I
S
S
G
G
Q
R
E
H
R
H
D
I
L
V
E
Q
I
K
E
K
G
L
N
P
-----
E
S
F
E
F
--
Y
L
K
A
F
R
Y
G
M
P
P
H
G
G
F
G
L
G
A
E
R
L
I
K
Q
M
L
D
L
P
N
I
R
E
V
I
L
F
P
R
D
R
R
R
L
T
P
4
PsiBlast_PDB
88.97
33%
-83
- C7 -
3M4P
5
?
A:
[19-456]
----------------
V
C
N
I
R
-
D
A
-
A
G
L
E
G
K
L
V
T
F
K
G
W
A
Y
H
I
R
K
A
R
K
-
T
-
L
I
F
V
E
L
R
D
G
S
G
Y
C
Q
C
V
I
F
G
K
E
L
C
E
P
----------
E
K
V
K
---
L
L
T
R
E
C
S
L
E
I
T
G
R
L
N
A
Y
A
GKNHPP
E
I
-----
A
---
D
--------
I
---
L
N
----
L
E
M
Q
V
T
E
W
K
V
I
G
-------------
E
-
S
----
P
I
DLENI
I
N
---
K
---------------------------
D
S
---------------
S
-----
I
P
Q
K
M
Q
N
R
H
I
V
I
R
S
E
H
T
Q
Q
V
L
Q
L
R
S
E
I
Q
W
Y
F
R
K
Y
Y
H
D
N
H
F
T
E
I
Q
P
P
T
I
V
K
------
S
T
L
F
K
L
Q
Y
F
N
E
P
A
Y
L
T
Q
S
S
Q
L
Y
L
E
-
S
V
-
I
A
S
-
L
G
K
S
F
C
M
L
S
S
Y
R
A
E
Q
S
R
T
V
R
H
L
A
E
Y
L
H
L
E
A
E
L
P
F
I
-
S
-
F
-
E
D
L
L
N
H
L
E
D
L
V
C
T
V
I
D
N
V
M
--
A
V
H
G
D
K
--
I
----
R
K
M
N
--
P
H
L
K
L
P
T
R
P
F
K
--------
R
M
T
Y
A
D
A
I
K
Y
C
N
--
D
H
G
I
L
N
K
D
K
P
F
---
E
Y
------
G
E
D
I
S
E
K
P
E
R
Q
----
M
T
D
E
I
----
G
-
C
-----
P
I
-
F
M
I
H
-
F
P
S
K
M
K
A
F
Y
M
S
K
V
P
G
H
P
D
L
T
E
S
V
D
L
L
M
P
-
G
V
G
-
E
I
V
G
G
S
M
R
I
W
N
Y
D
E
L
M
G
A
Y
K
A
N
G
L
N
P
-----
D
P
Y
Y
W
--
Y
T
Q
Q
R
K
Y
G
S
C
P
H
G
G
Y
G
L
G
V
E
R
L
V
M
W
L
L
G
E
D
H
I
R
K
V
C
L
Y
P
R
Y
L
E
R
C
E
P
5
PsiBlast_PDB
88.85
33%
-85
- C7 -
3M4Q
-
?
A:
[14-451]
----------------
V
C
N
I
R
-
D
A
-
A
G
L
E
G
K
L
V
T
F
K
G
W
A
Y
H
I
R
K
A
R
K
-
T
-
L
I
F
V
E
L
R
D
G
S
G
Y
C
Q
C
V
I
F
G
K
E
L
C
E
P
----------
E
K
V
K
---
L
L
T
R
E
C
S
L
E
I
T
G
R
L
N
A
Y
A
G
KNHPP
E
I
-----
A
---
D
--------
I
---
L
N
----
L
E
M
Q
V
T
E
W
K
V
I
G
-------------
E
-
S
----
P
I
D
L
E
N
I
I
N
---
K
---------------------------
D
S
---------------
S
-----
I
P
Q
K
M
Q
N
R
H
I
V
I
R
S
E
H
T
Q
Q
V
L
Q
L
R
S
E
I
Q
W
Y
F
R
K
Y
Y
H
D
N
H
F
T
E
I
Q
P
P
T
I
V
K
T
------
T
L
F
K
L
Q
Y
F
N
E
P
A
Y
L
T
Q
S
S
Q
L
Y
L
E
-
S
V
-
I
A
S
-
L
G
K
S
F
C
M
L
S
S
Y
R
A
E
------
H
L
A
E
Y
L
H
L
E
A
E
L
P
F
I
-
S
-
F
-
E
D
L
L
N
H
L
E
D
L
V
C
T
V
I
D
N
V
M
--
A
V
H
G
D
K
--
I
----
R
K
M
N
--
P
H
L
K
L
P
T
R
P
F
K
--------
R
M
T
Y
A
D
A
I
K
Y
C
N
--
D
H
G
I
L
N
K
D
K
P
F
---
E
Y
------
G
E
D
I
S
E
K
P
E
R
Q
----
M
T
D
E
I
----
G
-
C
-----
P
I
-
F
M
I
H
-
F
P
S
K
M
K
A
F
Y
M
S
K
V
P
G
H
P
D
L
T
E
S
V
D
L
L
M
P
-
G
V
G
-
E
I
V
G
G
S
M
R
I
W
N
Y
D
E
L
M
G
A
Y
K
A
N
G
L
N
P
-----
D
P
Y
Y
W
--
Y
T
Q
Q
R
K
Y
G
S
C
P
H
G
G
Y
G
L
G
V
E
R
L
V
M
W
L
L
G
E
D
H
I
R
K
V
C
L
Y
P
R
Y
L
E
R
C
E
P
6
PsiBlast_PDB
88.76
31%
-83
- C7 -
2XGT
3
?
A:
[1-435]
--------------
V
K
I
R
D
L
V
-
K
H
-
R
N
E
R
---
V
C
I
K
G
W
I
H
R
-
M
R
R
Q
G
-
K
S
L
M
F
F
I
L
R
D
G
T
G
F
L
Q
V
L
L
M
----------
D
K
L
C
Q
T
Y
D
A
L
T
----
V
N
T
E
C
T
V
E
I
Y
G
A
I
K
E
--------
V
P
----------------------
N
G
----
H
E
L
I
A
D
F
W
K
I
I
G
-------------
N
-
A
P
P
-
G
G
I
D
N
V
--
L
N
--------------------------------
A
---------------
S
-----
V
D
K
M
L
D
N
R
H
L
V
I
R
G
E
N
A
A
A
L
L
R
L
R
A
A
A
T
R
A
M
R
E
H
F
Y
N
A
G
Y
V
E
V
A
P
P
T
L
V
Q
T
Q
V
E
G
G
S
T
L
F
N
L
D
Y
F
G
E
Q
S
F
L
T
Q
S
S
Q
L
Y
L
E
-
T
C
-
I
P
T
-
L
G
D
V
F
C
I
A
Q
S
Y
R
A
E
K
S
R
T
R
R
H
L
A
E
Y
A
H
V
E
A
E
C
P
F
I
-
T
-
L
-
D
D
L
M
E
K
I
E
E
L
V
C
D
T
V
D
R
L
L
A
D
E
E
A
K
K
L
--
L
E
H
I
N
P
K
F
Q
--
P
P
E
R
----
P
F
L
--------
R
M
E
Y
K
D
A
I
K
W
L
Q
--
E
H
N
V
-
E
N
E
F
G
-
N
T
F
T
Y
------
G
E
D
I
A
E
A
A
E
R
F
----
M
T
D
T
I
----
N
-
K
-----
P
I
-
L
L
N
R
-
F
P
S
E
I
K
A
F
Y
M
Q
R
D
A
Q
D
N
T
L
T
E
S
V
D
L
L
M
P
-
G
V
G
-
E
I
V
G
G
S
M
R
I
W
K
F
D
E
L
S
K
A
F
K
N
V
E
I
D
P
-----
K
P
Y
Y
W
--
Y
L
D
Q
R
L
Y
G
T
C
P
H
G
G
Y
G
L
G
L
E
R
F
I
C
W
L
T
N
T
N
H
I
R
D
V
C
L
Y
P
R
F
V
G
R
C
V
P
60
HHSearch
88.47
33%
-77
- C7 -
2XGT
3
?
A:
[3-435]
----------------
I
R
D
L
V
-
K
H
-
R
N
E
R
---
V
C
I
K
G
W
I
H
R
-
M
R
R
Q
G
K
S
-
L
M
F
F
I
L
R
D
G
T
G
F
L
Q
V
L
L
M
D
K
L
----------
C
Q
T
Y
D
-
A
L
---
T
V
N
T
E
C
T
V
E
I
Y
G
A
I
K
E
--------
V
P
----------------------
N
G
----
H
E
L
I
A
D
F
W
K
I
I
G
-------------
N
-
A
P
P
-
G
G
I
-----
D
N
V
L
N-----------------------------
A
---------------
S
-----
V
D
K
M
L
D
N
R
H
L
V
I
R
G
E
N
A
A
A
L
L
R
L
R
A
A
A
T
R
A
M
R
E
H
F
Y
N
A
G
Y
V
E
V
A
P
P
T
L
V
Q
T
Q
V
E
G
G
S
T
L
F
N
L
D
Y
F
G
E
Q
S
F
L
T
Q
S
S
Q
L
Y
L
E
-
T
C
-
I
P
T
-
L
G
D
V
F
C
I
A
Q
S
Y
R
A
E
K
S
R
T
R
R
H
L
A
E
Y
A
H
V
E
A
E
C
P
F
I
-
T
-
L
-
D
D
L
M
E
K
I
E
E
L
V
C
D
T
V
D
R
L
L
--
A
D
E
E
A
K
K
L
L
E
H
I
N
P
K
-----
F
-
Q
P
P
E
R
P
F
L
--------
R
M
E
Y
K
D
A
I
K
W
L
Q
--
E
H
N
V
-
E
N
E
F
G
N
T
F
-
T
Y
------
G
E
D
I
A
E
A
A
E
R
F
----
M
T
D
T
I
----
N
-
K
-----
P
I
-
L
L
N
R
-
F
P
S
E
I
K
A
F
Y
M
Q
R
D
A
Q
D
N
T
L
T
E
S
V
D
L
L
M
P
-
G
V
G
-
E
I
V
G
G
S
M
R
I
W
K
F
D
E
L
S
K
A
F
K
N
V
E
I
D
P
-----
K
P
Y
Y
W
--
Y
L
D
Q
R
L
Y
G
T
C
P
H
G
G
Y
G
L
G
L
E
R
F
I
C
W
L
T
N
T
N
H
I
R
D
V
C
L
Y
P
R
F
V
G
R
C
V
P
16
PsiBlast_PDB
87.30
28%
-76
- C7 -
1EOV
-
SYDC_YEAST
A:
[95-557]
------------
K
F
V
D
L
D
E
A
K
-
D
--
S
D
K
E
---
V
L
F
R
A
R
V
H
N
-
T
R
Q
Q
G
A
T
-
L
A
F
L
T
L
R
Q
Q
A
S
L
I
Q
G
L
V
-------
K
A
N
K
E
G
T
I
S
K
-
N
M
V
K
W
A
G
S
L
N
L
E
S
I
V
L
V
R
G
I
V
K
K
V
-------
D
E
-----
P
---
I
--------
K
---
S
A
TVQN
L
E
I
H
I
T
K
I
Y
T
I
S
-------------
E
-
T
P
E
A
L
P
I
-----
L
L
---
E
---------------------------
D
A
S
RS
E
A
E
A
E
A
A
GLPVV
N
-----
L
D
T
R
L
D
Y
R
V
I
D
L
R
T
V
T
N
Q
A
I
F
R
I
Q
A
G
V
C
E
L
F
R
E
Y
L
A
T
K
K
F
T
E
V
H
T
P
K
L
L
G
A
P
S
E
G
G
S
S
V
F
E
V
T
Y
F
K
G
K
A
Y
L
A
Q
S
P
Q
F
N
K
Q
-
Q
L
-
I
V
A
D
F
E
R
V
Y
E
I
G
P
V
F
R
A
E
N
S
N
T
H
R
H
M
T
E
F
T
G
L
D
M
E
M
A
F
E
-
E
-
H
Y
H
E
V
L
D
T
L
S
E
L
F
V
F
I
F
S
E
L
P
--
K
R
F
A
H
E
--
I
E
L
V
R
--------
K
Q
Y
P
V
E
E
F
K
LPKDG
K
M
V
R
L
T
Y
K
E
G
I
E
M
L
R
--
A
-
A
G
-
K
E
I
G
D
F
E
------------
D
L
S
T
E
N
E
K
F
L
G
K
L
V
R
D
K
Y
----
D
-
T
-----
D
F
-
Y
I
L
D
K
F
P
L
E
I
R
P
F
Y
T
M
P
D
P
A
N
P
K
Y
S
N
S
Y
D
F
F
M
--
R
G
E
-
E
I
L
S
G
A
Q
R
I
H
D
H
A
L
L
Q
E
R
M
K
A
H
G
L
S
P
-----
E
D
P
G
L
K
D
Y
C
D
G
F
S
Y
G
C
P
P
H
A
G
G
G
I
G
L
E
R
V
V
M
F
Y
L
D
L
K
N
I
R
R
A
S
L
F
P
R
D
P
K
R
L
R
P
18
PsiBlast_PDB
86.97
28%
-78
- C7 -
1ASZ
1
SYDC_YEAST
A:
[28-490]
------------
K
F
V
D
L
D
E
A
K
-
D
--
S
D
K
E
---
V
L
F
R
A
R
V
H
N
-
T
R
Q
Q
G
A
T
-
L
A
F
L
T
L
R
Q
Q
A
S
L
I
Q
G
L
V
-------
K
A
N
K
E
G
T
I
S
K
-
N
M
V
K
W
A
G
S
L
N
L
E
S
I
V
L
V
R
G
I
V
K
K
V
-------
D
E
-----
P
---
I
--------
K
---
S
A
TVQN
L
E
I
H
I
T
K
I
Y
T
I
S
-------------
E
-
T
P
E
A
L
P
I
-----
L
L
---
E
---------------------------
D
A
S
RS
E
A
E
A
E
A
A
G
L
P
V
V
N
-----
L
D
T
R
L
D
Y
R
V
I
D
L
R
T
V
T
N
Q
A
I
F
R
I
Q
A
G
V
C
E
L
F
R
E
Y
L
A
T
K
K
F
T
E
V
H
T
P
K
L
L
G
A
P
S
E
G
G
S
S
V
F
E
V
T
Y
F
K
G
K
A
Y
L
A
Q
S
P
Q
F
N
K
Q
-
Q
L
-
I
V
A
D
F
E
R
V
Y
E
I
G
P
V
F
R
A
E
N
S
N
T
H
R
H
M
T
E
F
T
G
L
D
M
E
M
A
F
E
-
E
-
H
Y
H
E
V
L
D
T
L
S
E
L
F
V
F
I
F
S
E
L
P
--
K
R
F
A
H
E
--
I
E
L
V
R
--------
K
Q
Y
P
V
E
E
F
K
LPKDG
K
M
V
R
L
T
Y
K
E
G
I
E
M
L
R
--
A
-
A
G
-
K
E
I
G
D
F
E
------------
D
L
S
T
E
N
E
K
F
L
G
K
L
V
R
D
K
Y
----
D
-
T
-----
D
F
-
Y
I
L
D
K
F
P
L
E
I
R
P
F
Y
T
M
P
D
P
A
N
P
K
Y
S
N
S
Y
D
F
F
M
--
R
G
E
-
E
I
L
S
G
A
Q
R
I
H
D
H
A
L
L
Q
E
R
M
K
A
H
G
L
S
P
-----
E
D
P
G
L
KD
Y
C
D
G
F
S
Y
G
C
P
P
H
A
G
G
G
I
G
L
E
R
V
V
M
F
Y
L
D
L
K
N
I
R
R
A
S
L
F
P
R
D
P
K
R
L
R
P
9
PsiBlast_PDB
86.86
33%
-75
- C7 -
3NEM
1
SYD_THEKO
A:
[16-438]
--------------------------
G
Q
K
---
V
K
V
A
G
W
V
W
E
-
V
K
D
L
G
-
G
-
I
K
F
L
W
I
R
D
R
D
G
I
V
Q
I
T
A
P
K
--------
K
K
V
D
P
E
L
F
K
L
I
P
---
K
L
R
S
E
D
V
V
A
V
E
G
V
V
N
F
--------
T
P
-----
K
---
A
--------
K
---
L
G
----
F
E
I
L
P
E
K
I
V
V
L
N
-------------
R
-
A
E
T
P
L
P
L
-----
D
P
---
T
GK
V
------------------------
K
A
---------------
E
-----
L
D
T
R
L
D
N
R
F
M
D
L
R
R
P
E
V
M
A
I
F
K
I
R
S
S
V
F
K
A
V
R
D
F
F
H
E
N
G
F
I
E
I
H
T
P
K
I
I
A
T
A
T
E
G
G
T
E
L
F
P
M
K
Y
F
E
E
D
A
F
L
A
Q
S
P
Q
L
Y
K
Q
I
M
M
-
A
S
G
-
L
D
R
V
Y
E
I
A
P
I
F
R
A
E
E
H
N
T
T
R
H
L
N
E
A
W
S
I
D
S
E
M
A
F
I
-
E
D
E
-
E
E
V
M
S
F
L
E
R
L
V
A
H
A
I
N
Y
V
R
--
E
H
N
A
K
E
--
L
D
I
L
N
F
E
L
E
--
E
P
K
L
----
P
F
P
--------
R
V
S
Y
D
K
A
L
E
I
L
G
--
D
L
G
K
-
E
-------
I
P
W
------
G
E
D
I
D
T
E
G
E
R
L
----
L
G
K
Y
M
M
E
NE
N
-
A
-----
P
L
Y
F
L
Y
Q
-
Y
P
S
E
A
K
P
F
Y
I
M
K
Y
D
N
K
P
E
I
C
R
A
F
D
L
---
E
Y
R
G
V
E
I
S
S
G
G
Q
R
E
H
R
H
D
I
L
V
E
Q
I
K
E
K
G
L
N
P
-----
E
S
F
E
F
--
Y
L
K
A
F
R
Y
G
M
P
P
H
G
G
F
G
L
G
A
E
R
L
I
K
Q
M
L
D
L
P
N
I
R
E
V
I
L
F
P
R
D
R
R
R
L
T
P
26
PsiBlast_CBE
86.60
33%
-72
- C7 -
1B8A
3
SYD_THEKO
B:
[16-438]
--------------------------
G
Q
K
---
V
K
V
A
G
W
V
W
E
-
V
K
D
L
G
-
G
-
I
K
F
L
W
I
R
D
R
D
G
I
V
Q
I
T
A
P
K
--------
K
K
V
D
P
E
L
F
K
L
I
P
---
K
L
R
S
E
D
V
V
A
V
E
G
V
V
N
F
--------
T
P
-----
K
---
A
--------
K
---
L
G
----
F
E
I
L
P
E
K
I
V
V
L
N
-------------
R
-
A
E
T
P
L
P
L
-----
D
P
---
T
GKV------------------------
K
A
---------------
E
-----
L
D
T
R
L
N
N
R
F
M
D
L
R
R
P
E
V
M
A
I
F
K
I
R
S
S
V
F
K
A
V
R
D
F
F
H
E
N
G
F
I
E
I
H
T
P
K
I
I
A
T
A
T
E
G
G
T
E
L
F
P
M
K
Y
F
E
E
D
A
F
L
A
E
S
P
Q
L
Y
K
E
I
M
M
-
A
S
G
-
L
D
R
V
Y
E
I
A
P
I
F
R
A
E
E
H
N
T
T
R
H
L
N
E
A
W
S
I
D
S
E
M
A
F
I
-
E
D
E
-
E
E
V
M
S
F
L
E
R
L
V
A
H
A
I
N
Y
V
R
--
E
H
N
A
K
E
--
L
D
I
L
N
F
E
L
E
--
E
P
K
L
----
P
F
P
--------
R
V
S
Y
D
K
A
L
E
I
L
G
--
D
L
G
K
-
E
-------
I
P
W
------
G
E
D
I
D
T
E
G
E
R
L
----
L
G
K
Y
M
MENE
N
-
A
-----
P
L
Y
F
L
Y
Q
-
Y
P
S
E
A
K
P
F
Y
I
M
K
Y
D
N
K
P
E
I
C
R
A
F
D
L
---
E
Y
R
G
V
E
I
S
S
G
G
Q
R
E
H
R
H
D
I
L
V
E
Q
I
K
E
K
G
L
N
P
-----
E
S
F
E
F
--
Y
L
K
A
F
R
Y
G
M
P
P
H
G
G
F
G
L
G
A
E
R
L
I
K
Q
M
L
D
L
P
N
I
R
E
V
I
L
F
P
R
D
R
R
R
L
T
P
25
PsiBlast_CBE
86.48
33%
-72
- C7 -
3NEM
3
SYD_THEKO
B:
[16-438]
--------------------------
G
Q
K
---
V
K
V
A
G
W
V
W
E
-
V
K
D
L
G
-
G
-
I
K
F
L
W
I
R
D
R
D
G
I
V
Q
I
T
A
P
K
--------
K
K
V
D
P
E
L
F
K
L
I
P
---
K
L
R
S
E
D
V
V
A
V
E
G
V
V
N
F
--------
T
P
-----
K
---
A
--------
K
---
L
G
----
F
E
I
L
P
E
K
I
V
V
L
N
-------------
R
-
A
E
T
P
L
P
L
-----
D
P
---
T
GKV------------------------
K
A
---------------
E
-----
L
D
T
R
L
D
N
R
F
M
D
L
R
R
P
E
V
M
A
I
F
K
I
R
S
S
V
F
K
A
V
R
D
F
F
H
E
N
G
F
I
E
I
H
T
P
K
I
I
A
T
A
T
E
G
G
T
E
L
F
P
M
K
Y
F
E
E
D
A
F
L
A
Q
S
P
Q
L
Y
K
Q
I
M
M
-
A
S
G
-
L
D
R
V
Y
E
I
A
P
I
F
R
A
E
E
H
N
T
T
R
H
L
N
E
A
W
S
I
D
S
E
M
A
F
I
-
E
D
E
-
E
E
V
M
S
F
L
E
R
L
V
A
H
A
I
N
Y
V
R
--
E
H
N
A
K
E
--
L
D
I
L
N
F
E
L
E
--
E
P
K
L
----
P
F
P
--------
R
V
S
Y
D
K
A
L
E
I
L
G
--
D
L
G
K
-
E
-------
I
P
W
------
G
E
D
I
D
T
E
G
E
R
L
----
L
G
K
Y
M
MENE
N
-
A
-----
P
L
Y
F
L
Y
Q
-
Y
P
S
E
A
K
P
F
Y
I
M
K
Y
D
N
K
P
E
I
C
R
A
F
D
L
---
E
Y
R
G
V
E
I
S
S
G
G
Q
R
E
H
R
H
D
I
L
V
E
Q
I
K
E
K
G
L
N
P
-----
E
S
F
E
F
--
Y
L
K
A
F
R
Y
G
M
P
P
H
G
G
F
G
L
G
A
E
R
L
I
K
Q
M
L
D
L
P
N
I
R
E
V
I
L
F
P
R
D
R
R
R
L
T
P
11
PsiBlast_PDB
86.24
33%
-72
- C7 -
1B8A
4
SYD_THEKO
A:
[16-438]
--------------------------
G
Q
K
---
V
K
V
A
G
W
V
W
E
-
V
K
D
L
G
-
G
-
I
K
F
L
W
I
R
D
R
D
G
I
V
Q
I
T
A
P
K
--------
K
K
V
D
P
E
L
F
K
L
I
P
---
K
L
R
S
E
D
V
V
A
V
E
G
V
V
N
F
--------
T
P
-----
K
---
A
--------
K
---
L
G
----
F
E
I
L
P
E
K
I
V
V
L
N
-------------
R
-
A
E
T
P
L
P
L
-----
D
P
---
T
GK
V
------------------------
K
A
---------------
E
-----
L
D
T
R
L
N
N
R
F
M
D
L
R
R
P
E
V
M
A
I
F
K
I
R
S
S
V
F
K
A
V
R
D
F
F
H
E
N
G
F
I
E
I
H
T
P
K
I
I
A
T
A
T
E
G
G
T
E
L
F
P
M
K
Y
F
E
E
D
A
F
L
A
E
S
P
Q
L
Y
K
E
I
M
M
-
A
S
G
-
L
D
R
V
Y
E
I
A
P
I
F
R
A
E
E
H
N
T
T
R
H
L
N
E
A
W
S
I
D
S
E
M
A
F
I
-
E
D
E
-
E
E
V
M
S
F
L
E
R
L
V
A
H
A
I
N
Y
V
R
--
E
H
N
A
K
E
--
L
D
I
L
N
F
E
L
E
--
E
P
K
L
----
P
F
P
--------
R
V
S
Y
D
K
A
L
E
I
L
G
--
D
L
G
K
-
E
-------
I
P
W
------
G
E
D
I
D
T
E
G
E
R
L
----
L
G
K
Y
M
M
E
N
E
N
-
A
-----
P
L
Y
F
L
Y
Q
-
Y
P
S
E
A
K
P
F
Y
I
M
K
Y
D
N
K
P
E
I
C
R
A
F
D
L
---
E
Y
R
G
V
E
I
S
S
G
G
Q
R
E
H
R
H
D
I
L
V
E
Q
I
K
E
K
G
L
N
P
-----
E
S
F
E
F
--
Y
L
K
A
F
R
Y
G
M
P
P
H
G
G
F
G
L
G
A
E
R
L
I
K
Q
M
L
D
L
P
N
I
R
E
V
I
L
F
P
R
D
R
R
R
L
T
P
8
PsiBlast_PDB
86.17
33%
-73
- C7 -
3NEL
1
SYD_THEKO
A:
[16-438]
--------------------------
G
Q
K
---
V
K
V
A
G
W
V
W
E
-
V
K
D
L
G
-
G
-
I
K
F
L
W
I
R
D
R
D
G
I
V
Q
I
T
A
P
K
--------
K
K
V
D
P
E
L
F
K
L
I
P
---
K
L
R
S
E
D
V
V
A
V
E
G
V
V
N
F
--------
T
P
-----
K
---
A
--------
K
---
L
G
----
F
E
I
L
P
E
K
I
V
V
L
N
-------------
R
-
A
E
T
P
L
P
L
-----
D
P
---
T
GK
V
------------------------
K
A
---------------
E
-----
L
D
T
R
L
D
N
R
F
M
D
L
R
R
P
E
V
M
A
I
F
K
I
R
S
S
V
F
K
A
V
R
D
F
F
H
E
N
G
F
I
E
I
H
T
P
K
I
I
A
T
A
T
E
G
G
T
E
L
F
P
M
K
Y
F
E
E
D
A
F
L
A
Q
S
P
Q
L
Y
K
Q
I
M
M
-
A
S
G
-
L
D
R
V
Y
E
I
A
P
I
F
R
A
E
E
H
N
T
T
R
H
L
N
E
A
W
S
I
D
S
E
M
A
F
I
-
E
D
E
-
E
E
V
M
S
F
L
E
R
L
V
A
H
A
I
N
Y
V
R
--
E
H
N
A
K
E
--
L
D
I
L
N
F
E
L
E
--
E
P
K
L
----
P
F
P
--------
R
V
S
Y
D
K
A
L
E
I
L
G
--
D
L
G
K
-
E
-------
I
P
W
------
G
E
D
I
D
T
E
G
E
R
L
----
L
G
K
Y
M
M
E
N
E
N
-
A
-----
P
L
Y
F
L
Y
Q
-
Y
P
S
E
A
K
P
F
Y
I
M
K
Y
D
N
K
P
E
I
C
R
A
F
D
L
---
E
Y
R
G
V
E
I
S
S
G
G
Q
R
E
H
R
H
D
I
L
V
E
Q
I
K
E
K
G
L
N
P
-----
E
S
F
E
F
--
Y
L
K
A
F
R
Y
G
M
P
P
H
G
G
F
G
L
G
A
E
R
L
I
K
Q
M
L
D
L
P
N
I
R
E
V
I
L
F
P
R
D
R
R
R
L
T
P
73
Fugue
85.62
35%
-80
- C7 -
1B8A
4
SYD_THEKO
A:
[1-438]
MYRTHYSSE
I
T
------
E
-
E
L
-
N
G
---
Q
K
---
V
K
V
A
G
W
V
W
E
-
V
K
D
L
G
-
G
-
I
K
F
L
W
I
R
D
R
D
G
I
V
Q
I
T
A
P
K
-----
K
K
V
D
P
E
L
F
K
---
L
I
P
---
K
L
R
S
E
D
V
V
A
V
E
G
V
V
N
F
--------
T
P
------KAK-------------
L
G
----
F
E
I
L
P
E
K
I
V
V
L
N
R
A
E
T
PLPLDPTGK-------------------
V
---------------------------
K
A
---------------
E
-----
L
D
T
R
L
N
N
R
F
M
D
L
R
R
P
E
V
M
A
I
F
K
I
R
S
S
V
F
K
A
V
R
D
F
F
H
E
N
G
F
I
E
I
H
T
P
K
I
I
A
T
A
T
E
G
G
T
E
L
F
P
M
K
Y
F
E
E
D
A
F
L
A
E
S
P
Q
L
Y
K
E
-
I
M
-
M
A
S
G
L
D
R
V
Y
E
I
A
P
I
F
R
A
E
E
H
N
T
T
R
H
L
N
E
A
W
S
I
D
S
E
M
A
F
I
E
D
-
E
-
E
E
V
M
S
F
L
E
R
L
V
A
H
A
I
N
Y
V
R
--
E
H
N
A
K
E
--
L
D
I
L
N
--
F
E
L
E
E
P
K
L
----
P
F
P
--------
R
V
S
Y
D
K
A
L
E
I
L
G
D
L
----------------G
K
E
I
P
W
G
E
D
I
D
T
E
G
E
R
L
----
L
G
K
Y
M
----
M
-
E
N
ENAP
L
Y
-
F
L
Y
Q
-
Y
P
S
E
A
K
P
F
Y
I
M
K
Y
D
N
K
P
E
I
C
R
A
F
D
L
E
Y
--
R
G
V
-
E
I
S
S
G
G
Q
R
E
H
R
H
D
I
L
V
E
Q
I
K
E
K
----GLNPE-
S
F
E
F
--
Y
L
K
A
F
R
Y
G
M
P
P
H
G
G
F
G
L
G
A
E
R
L
I
K
Q
M
L
D
L
P
N
I
R
E
V
I
L
F
P
R
D
R
R
R
L
T
P