@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0771: (2015-12-03 )
MSNQHIEELNDQQIVRREKMAALTEQGIDPFGKRFERTATSGQLNEKYADKSKEDLHDIEETATIAGRLMTKRGKGKVGFAHIQDREGQIQIYVRKDSVGEENYEIFKKADLGDFLGVEGQVMRTDMGELSIKATHITHLSKALRPLPEKFHGLTDIETIYRKRHLDLISNRDSFDRFVTRSKIISEIRRFMDSNGFLEVETPVLHNEAGGASARPFITHHNAQDIDMVLRIATELHLKRLIVGGMERVYEIGRIFRNEGMDATHNPEFTSIEAYQAYADYQDIMDLTEGIIQHVTKTVKGDGPINYQGTEIKINEPFKRVHMVDAVKEITGIDFWKEMTLEEAQALAQEKNVPLEKHFTTVGHIINAFFEEFVEDTLIQPTFVFGHPVEVSPLAKKNDTDPRFTDRFELFIMTKEYANAFTELNDPIDQLSRFEAQASAKELGDDEATGVDYDYVEALEYGMPPTGGLGIGIDRLCMLLTDTTTIRDVLLFPTMK
Atome Classification :
(29 SA)
.......--..10....--....20........30........40........50........60........70.....-.-..80........90...--.....100..-...----..110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......----290.......300--....-----.....310.......320.......330-.......-340---.....--------....350....-----...360.......370.......380--........390.......400.-----......410.......420.......430.....----------------------------------..440.......450.......460.......470.......480.......490....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MS
N
Q
H
I
E
--EL
N
D
Q
Q
I
V
--
R
R
E
K
M
A
A
L
T
E
QGI
D
P
F
G
K
R
F
E
RTATSGQL
N
E
K
YADK
S
K
E
D
L
H
D
I
E
E
T
A
T
I
A
G
R
L
M
TKRGKG-K-V
G
F
A
H
IQDREG
Q
I
Q
I
Y
V
--RKDSVGEE
N
Y
-
E
I
F
----KKADL
G
D
FLGVE
G
Q
V
M
R
TDMG
E
L
S
I
K
A
T
H
I
T
H
L
S
K
A
L
R
P
L
P
E
K
FHGL
T
D
I
E
T
I
Y
R
K
R
H
L
D
L
ISN
R
D
S
F
D
R
F
V
T
R
S
K
I
I
S
E
I
R
R
F
MDSNG
F
L
E
VET
P
V
L
HNEAGGASAR
P
F
I
THHN
A
Q
D
I
D
M
V
L
R
I
A
T
E
L
H
L
K
R
L
I
V
G
G
M
E
R
V
Y
E
I
G
R
I
F
R
NEGMDATHNPEFT
S
I
E
A
Y
Q
A
YA
D
Y
Q
D
I
M
D
L
T
E
----
G
I
I
Q
H
V
T
K
T
VK----GDGP-----INYQG
T
E
I
K
INE
P
F
K
R
V
H
M
V
D
A
V
K
E
I
T
G
-
I
D
F
W
K
E
M
-
T
-----
L
E
E
A
Q
--------
A
L
A
Q
EKNV
P
L
E
-----
K
H
F
T
T
V
G
H
I
I
N
A
F
F
E
E
F
V
E
D
TLIQ
P
---
T
F
VFGHPVEVSPLAKKNDTDPR-----FT
D
R
F
E
L
F
I
M
T
K
E
Y
A
N
A
F
T
ELN
D
P
I
D
Q
L
S
R
F
E
A
Q
----------------------------------
A
S
A
K
ELGDDEATGV
D
Y
D
Y
V
E
A
L
EYGMPPTGGL
G
I
G
I
D
R
L
C
M
L
LTDTT
T
I
R
D
V
L
LFPTMK
2
PsiBlast_PDB
99.58
62%
-80
- C6 -
3E9I
4
SYK_GEOSE
A:
[4-491]
---------
E
L
N
D
Q
L
R
V
--
R
R
E
K
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
-
A
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
--
R
Q
D
D
V
G
E
Q
Q
Y
-
E
L
F
----
K
I
S
D
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
----
N
L
I
A
H
I
A
T
E
V
L
----
G
T
T
K
-----
I
Q
Y
G
E
H
L
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
Y
V
G
-
V
D
F
W
R
Q
M
-
S
-----
D
E
E
A
R
--------
E
L
A
K
E
H
G
V
E
V
A
-----
P
H
M
-
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
L
A
K
K
N
P
D
D
P
R
-----
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
----------------------------------
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
22
PsiBlast_CBE
99.55
62%
-80
- C6 -
3E9I
4
SYK_GEOSE
C:
[4-491]
---------
E
L
N
D
Q
L
R
V
--
R
R
E
K
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
-
A
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
--
R
Q
D
D
V
G
E
Q
Q
Y
-
E
L
F
----
K
I
S
D
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
----
N
L
I
A
H
I
A
T
E
V
L
----
G
T
T
K
-----
I
Q
Y
G
E
H
L
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
Y
V
G
-
V
D
F
W
R
Q
M
-
S
-----
D
E
E
A
R
--------
E
L
A
K
E
H
G
V
E
V
A
-----
P
H
M
-
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
L
A
K
K
N
P
D
D
P
R
-----
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
----------------------------------
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
3
PsiBlast_PDB
99.28
62%
-79
- C6 -
3A74
5
SYK_GEOSE
A:
[4-491]
---------
E
L
N
D
Q
L
R
V
--
R
R
E
K
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
-
A
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
--
R
Q
D
D
V
G
E
Q
Q
Y
-
E
L
F
----
K
I
S
D
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
----
N
L
I
A
H
I
A
T
E
V
L
----
G
T
T
K
-----
I
Q
Y
G
E
H
L
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
Y
V
G
-
V
D
F
W
R
Q
M
-
S
-----
D
E
E
A
R
--------
E
L
A
K
E
H
G
V
E
V
A
-----
P
H
M
-
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
L
A
K
K
N
P
D
D
P
R
-----
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
----------------------------------
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
28
PsiBlast_CBE
99.14
62%
-79
- C6 -
3A74
5
SYK_GEOSE
C:
[4-491]
---------
E
L
N
D
Q
L
R
V
--
R
R
E
K
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
-
A
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
--
R
Q
D
D
V
G
E
Q
Q
Y
-
E
L
F
----
K
I
S
D
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
----
N
L
I
A
H
I
A
T
E
V
L
----
G
T
T
K
-----
I
Q
Y
G
E
H
L
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
Y
V
G
-
V
D
F
W
R
Q
M
-
S
-----
D
E
E
A
R
--------
E
L
A
K
E
H
G
V
E
V
A
-----
P
H
M
-
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
L
A
K
K
N
P
D
D
P
R
-----
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
----------------------------------
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
29
PsiBlast_CBE
99.08
62%
-79
- C6 -
3A74
5
SYK_GEOSE
B:
[4-491]
---------
E
L
N
D
Q
L
R
V
--
R
R
E
K
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
-
A
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
--
R
Q
D
D
V
G
E
Q
Q
Y
-
E
L
F
----
K
I
S
D
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
----
N
L
I
A
H
I
A
T
E
V
L
----
G
T
T
K
-----
I
Q
Y
G
E
H
L
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
Y
V
G
-
V
D
F
W
R
Q
M
-
S
-----
D
E
E
A
R
--------
E
L
A
K
E
H
G
V
E
V
A
-----
P
H
M
-
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
L
A
K
K
N
P
D
D
P
R
-----
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
----------------------------------
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
1
PsiBlast_PDB
99.05
62%
-79
- C6 -
3E9H
2
SYK_GEOSE
A:
[4-491]
---------
E
L
N
D
Q
L
R
V
--
R
R
E
K
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
-
A
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
--
R
Q
D
D
V
G
E
Q
Q
Y
-
E
L
F
----
K
I
S
D
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
----
N
L
I
A
H
I
A
T
E
V
L
----
G
T
T
K
-----
I
Q
Y
G
E
H
L
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
Y
V
G
-
V
D
F
W
R
Q
M
-
S
-----
D
E
E
A
R
--------
E
L
A
K
E
H
G
V
E
V
A
-----
P
H
M
-
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
L
A
K
K
N
P
D
D
P
R
-----
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
----------------------------------
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
27
PsiBlast_CBE
98.97
62%
-79
- C6 -
3A74
5
SYK_GEOSE
D:
[4-491]
---------
E
L
N
D
Q
L
R
V
--
R
R
E
K
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
-
A
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
--
R
Q
D
D
V
G
E
Q
Q
Y
-
E
L
F
----
K
I
S
D
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
----
N
L
I
A
H
I
A
T
E
V
L
----
G
T
T
K
-----
I
Q
Y
G
E
H
L
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
Y
V
G
-
V
D
F
W
R
Q
M
-
S
-----
D
E
E
A
R
--------
E
L
A
K
E
H
G
V
E
V
A
-----
P
H
M
-
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
L
A
K
K
N
P
D
D
P
R
-----
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
----------------------------------
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
26
PsiBlast_CBE
98.93
62%
-79
- C6 -
3E9H
2
SYK_GEOSE
B:
[4-491]
---------
E
L
N
D
Q
L
R
V
--
R
R
E
K
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
-
A
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
--
R
Q
D
D
V
G
E
Q
Q
Y
-
E
L
F
----
K
I
S
D
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
----
N
L
I
A
H
I
A
T
E
V
L
----
G
T
T
K
-----
I
Q
Y
G
E
H
L
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
Y
V
G
-
V
D
F
W
R
Q
M
-
S
-----
D
E
E
A
R
--------
E
L
A
K
E
H
G
V
E
V
A
-----
P
H
M
-
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
L
A
K
K
N
P
D
D
P
R
-----
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
----------------------------------
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
24
PsiBlast_CBE
98.90
62%
-80
- C6 -
3E9H
2
SYK_GEOSE
D:
[4-491]
---------
E
L
N
D
Q
L
R
V
--
R
R
E
K
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
-
A
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
--
R
Q
D
D
V
G
E
Q
Q
Y
-
E
L
F
----
K
I
S
D
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
----
N
L
I
A
H
I
A
T
E
V
L
----
G
T
T
K
-----
I
Q
Y
G
E
H
L
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
Y
V
G
-
V
D
F
W
R
Q
M
-
S
-----
D
E
E
A
R
--------
E
L
A
K
E
H
G
V
E
V
A
-----
P
H
M
-
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
L
A
K
K
N
P
D
D
P
R
-----
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
----------------------------------
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
25
PsiBlast_CBE
98.64
62%
-79
- C6 -
3E9H
2
SYK_GEOSE
C:
[4-491]
---------
E
L
N
D
Q
L
R
V
--
R
R
E
K
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
-
A
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
--
R
Q
D
D
V
G
E
Q
Q
Y
-
E
L
F
----
K
I
S
D
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
----
N
L
I
A
H
I
A
T
E
V
L
----
G
T
T
K
-----
I
Q
Y
G
E
H
L
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
Y
V
G
-
V
D
F
W
R
Q
M
-
S
-----
D
E
E
A
R
--------
E
L
A
K
E
H
G
V
E
V
A
-----
P
H
M
-
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
L
A
K
K
N
P
D
D
P
R
-----
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
----------------------------------
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
61
HHSearch
98.63
62%
-78
- C6 -
3A74
5
SYK_GEOSE
A:
[5-491]
----------
L
N
D
Q
L
R
V
--
R
R
E
K
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
-
A
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
--
R
Q
D
D
V
G
E
Q
Q
Y
-
E
L
F
----
K
I
S
D
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
----
N
L
I
A
H
I
A
T
E
V
L
----
G
T
T
K
-----
I
Q
Y
G
E
H
L
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
Y
V
G
-
V
D
F
W
R
Q
M
-
S
-----
D
E
E
A
R
--------
E
L
A
K
E
H
G
V
E
V
------
A
P
H
M
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
L
A
K
K
N
P
D
D
P
R
-----
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
----------------------------------
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
21
PsiBlast_CBE
98.29
62%
-79
- C6 -
3E9I
4
SYK_GEOSE
D:
[4-491]
---------
E
L
N
D
Q
L
R
V
--
R
R
E
K
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
-
A
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
--
R
Q
D
D
V
G
E
Q
Q
Y
-
E
L
F
----
K
I
S
D
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
----
N
L
I
A
H
I
A
T
E
V
L
----
G
T
T
K
-----
I
Q
Y
G
E
H
L
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
Y
V
G
-
V
D
F
W
R
Q
M
-
S
-----
D
E
E
A
R
--------
E
L
A
K
E
H
G
V
E
V
A
-----
P
H
M
-
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
L
A
K
K
N
P
D
D
P
R
-----
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
----------------------------------
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
23
PsiBlast_CBE
97.75
62%
-78
- C6 -
3E9I
4
SYK_GEOSE
B:
[4-491]
---------
E
L
N
D
Q
L
R
V
--
R
R
E
K
L
K
K
I
E
E
L
G
V
D
P
F
G
K
R
F
E
R
T
H
K
A
E
E
L
F
E
L
Y
G
D
L
S
K
E
E
L
E
E
Q
Q
I
E
V
A
V
A
G
R
I
M
T
K
R
G
M
G
-
K
-
A
G
F
A
H
I
Q
D
V
T
G
Q
I
Q
I
Y
V
--
R
Q
D
D
V
G
E
Q
Q
Y
-
E
L
F
----
K
I
S
D
L
G
D
I
V
G
V
R
G
T
M
F
K
T
K
V
G
E
L
S
I
K
V
S
S
Y
E
F
L
T
K
A
L
R
P
L
P
E
-----
K
D
I
E
Q
R
Y
R
Q
R
Y
L
D
L
I
M
N
P
E
S
K
K
T
F
I
T
R
S
L
I
I
Q
S
M
R
R
Y
L
D
S
H
G
Y
L
E
V
E
T
P
M
M
H
A
V
A
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
M
T
L
Y
M
R
I
A
I
E
L
H
L
K
R
L
I
V
G
G
L
E
K
V
Y
E
I
G
R
V
F
R
N
E
G
I
S
T
R
H
N
P
E
F
T
M
L
E
L
Y
E
A
Y
A
D
F
R
D
I
M
K
L
T
E
----
N
L
I
A
H
I
A
T
E
V
L
----
G
T
T
K
-----
I
Q
Y
G
E
H
L
V
D
L
T
P
E
W
R
R
L
H
M
V
D
A
I
K
E
Y
V
G
-
V
D
F
W
R
Q
M
-
S
-----
D
E
E
A
R
--------
E
L
A
K
E
H
G
V
E
V
A
-----
P
H
M
-
T
F
G
H
I
V
N
E
F
F
E
Q
K
V
E
D
K
L
I
Q
P
---
T
F
I
Y
G
H
P
V
E
I
S
P
L
A
K
K
N
P
D
D
P
R
-----
F
T
D
R
F
E
L
F
I
V
G
R
E
H
A
N
A
F
T
E
L
N
D
P
I
D
Q
R
Q
R
F
E
E
Q
----------------------------------
L
K
E
R
E
Q
G
N
D
E
A
H
E
M
D
E
D
F
L
E
A
L
E
Y
G
M
P
P
T
G
G
L
G
I
G
V
D
R
L
V
M
L
L
T
N
S
P
S
I
R
D
V
L
L
F
P
Q
M
R
4
PsiBlast_PDB
93.24
50%
-71
- C6 -
1LYL
1
SYK2_ECOLI
A:
[14-501]
----------
F
N
D
E
L
R
N
--
R
R
E
K
L
A
A
L
R
Q
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
E
S
L
N
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
-
K
-
A
S
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
--
A
R
D
S
L
P
E
G
V
Y
N
D
Q
F
----
K
K
W
D
L
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
----
S
L
F
R
T
L
A
Q
E
V
L
----
G
T
T
K
-----
V
T
Y
G
E
H
V
F
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
K
K
Y
R
P
E
T
D
M
A
D
L
D
-
N
-----
F
D
A
A
K
--------
A
L
A
E
S
I
G
I
T
V
E
-----
K
S
W
-
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
I
Q
P
---
T
F
I
T
E
Y
P
A
E
V
S
P
L
A
R
R
N
D
V
N
P
E
-----
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
----------------------------------
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
9
PsiBlast_PDB
92.63
50%
-70
- C6 -
1BBU
1
SYK1_ECOLI
A:
[11-501]
-------VV
D
L
N
N
E
L
K
T
--
R
R
E
K
L
A
N
L
R
E
Q
G
I
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
A
E
F
D
G
K
E
N
E
E
L
E
A
L
N
I
E
V
A
V
A
G
R
M
M
T
R
R
I
M
G
-
K
-
A
S
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
--
A
R
D
D
L
P
E
G
V
Y
N
E
Q
F
----
K
K
W
D
L
G
D
I
L
G
A
K
G
K
L
F
K
T
K
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
------
D
Q
E
A
R
Y
R
Q
R
Y
L
D
L
I
S
N
D
E
S
R
N
T
F
K
V
R
S
Q
I
L
S
G
I
R
Q
F
M
V
N
R
G
F
M
E
V
E
T
P
M
M
Q
V
I
P
G
G
A
A
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
K
D
L
I
E
L
T
E
----
S
L
F
R
T
L
A
Q
D
I
L
----
G
K
T
E
-----
V
T
Y
G
D
V
T
L
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
K
K
Y
R
P
E
T
D
M
A
D
L
D
-
N
-----
F
D
S
A
K
--------
A
I
A
E
S
I
G
I
H
V
E
-----
K
S
W
-
G
L
G
R
I
V
T
E
I
F
E
E
V
A
E
A
H
L
I
Q
P
---
T
F
I
T
E
Y
P
A
E
V
S
P
L
A
R
R
N
D
V
N
P
E
-----
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
Q
R
F
L
D
Q
----------------------------------
V
A
A
K
D
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
H
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
V
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
30
PsiBlast_CBE
92.23
50%
-72
- C6 -
1LYL
1
SYK2_ECOLI
C:
[14-501]
----------
F
N
D
E
L
R
N
--
R
R
E
K
L
A
A
L
R
Q
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
E
S
L
N
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
-
K
-
A
S
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
--
A
R
D
S
L
P
E
G
V
Y
N
D
Q
F
----
K
K
W
D
L
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
----
S
L
F
R
T
L
A
Q
E
V
L
----
G
T
T
K
-----
V
T
Y
G
E
H
V
F
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
K
K
Y
R
P
E
T
D
M
A
D
L
D
-
N
-----
F
D
A
A
K
--------
A
L
A
E
S
I
G
I
T
V
E
-----
K
S
W
-
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
I
Q
P
---
T
F
I
T
E
Y
P
A
E
V
S
P
L
A
R
R
N
D
V
N
P
E
-----
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
----------------------------------
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
31
PsiBlast_CBE
91.95
50%
-71
- C6 -
1LYL
1
SYK2_ECOLI
B:
[14-501]
----------
F
N
D
E
L
R
N
--
R
R
E
K
L
A
A
L
R
Q
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
E
S
L
N
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
-
K
-
A
S
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
--
A
R
D
S
L
P
E
G
V
Y
N
D
Q
F
----
K
K
W
D
L
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
------
D
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
----
S
L
F
R
T
L
A
Q
E
V
L
----
G
T
T
K
-----
V
T
Y
G
E
H
V
F
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
K
K
Y
R
P
E
T
D
M
A
D
L
D
-
N
-----
F
D
A
A
K
--------
A
L
A
E
S
I
G
I
T
V
E
-----
K
S
W
-
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
I
Q
P
---
T
F
I
T
E
Y
P
A
E
V
S
P
L
A
R
R
N
D
V
N
P
E
-----
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
----------------------------------
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
8
PsiBlast_PDB
91.72
50%
-72
- C6 -
1E24
7
SYK2_ECOLI
A:
[11-501]
----
A
I
D
---
F
N
D
E
L
R
N
--
R
R
E
K
L
A
A
L
R
Q
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
E
S
L
N
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
-
K
-
A
S
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
--
A
R
D
S
L
P
E
G
V
Y
N
D
Q
F
----
K
K
W
D
L
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
----
S
L
F
R
T
L
A
Q
E
V
L
----
G
T
T
K
-----
V
T
Y
G
E
H
V
F
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
K
K
Y
R
P
E
T
D
M
A
D
L
D
-
N
-----
F
D
A
A
K
--------
A
L
A
E
S
I
G
I
T
V
E
-----
K
S
W
-
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
I
Q
P
---
T
F
I
T
E
Y
P
A
E
V
S
P
L
A
R
R
N
D
V
N
P
E
-----
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
----------------------------------
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
6
PsiBlast_PDB
91.65
50%
-71
- C6 -
1E1T
11
SYK2_ECOLI
A:
[11-501]
----
A
I
D
---
F
N
D
E
L
R
N
--
R
R
E
K
L
A
A
L
R
Q
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
E
S
L
N
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
-
K
-
A
S
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
--
A
R
D
S
L
P
E
G
V
Y
N
D
Q
F
----
K
K
W
D
L
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
----
S
L
F
R
T
L
A
Q
E
V
L
----
G
T
T
K
-----
V
T
Y
G
E
H
V
F
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
K
K
Y
R
P
E
T
D
M
A
D
L
D
-
N
-----
F
D
A
A
K
--------
A
L
A
E
S
I
G
I
T
V
E
-----
K
S
W
-
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
I
Q
P
---
T
F
I
T
E
Y
P
A
E
V
S
P
L
A
R
R
N
D
V
N
P
E
-----
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
----------------------------------
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
5
PsiBlast_PDB
91.58
50%
-71
- C6 -
1E1O
9
SYK2_ECOLI
A:
[11-501]
----
A
I
D
---
F
N
D
E
L
R
N
--
R
R
E
K
L
A
A
L
R
Q
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
E
S
L
N
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
-
K
-
A
S
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
--
A
R
D
S
L
P
E
G
V
Y
N
D
Q
F
----
K
K
W
D
L
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
-
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
----
S
L
F
R
T
L
A
Q
E
V
L
----
G
T
T
K
-----
V
T
Y
G
E
H
V
F
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
K
K
Y
R
P
E
T
D
M
A
D
L
D
-
N
-----
F
D
A
A
K
--------
A
L
A
E
S
I
G
I
T
V
E
-----
K
S
W
-
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
I
Q
P
---
T
F
I
T
E
Y
P
A
E
V
S
P
L
A
R
R
N
D
V
N
P
E
-----
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
----------------------------------
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
7
PsiBlast_PDB
91.15
50%
-71
- C6 -
1E22
11
SYK2_ECOLI
A:
[11-501]
----
A
I
D
---
F
N
D
E
L
R
N
--
R
R
E
K
L
A
A
L
R
Q
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
E
S
L
N
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
-
K
-
A
S
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
--
A
R
D
S
L
P
E
G
V
Y
N
D
Q
F
----
K
K
W
D
L
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
----
S
L
F
R
T
L
A
Q
E
V
L
----
G
T
T
K
-----
V
T
Y
G
E
H
V
F
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
K
K
Y
R
P
E
T
D
M
A
D
L
D
-
N
-----
F
D
A
A
K
--------
A
L
A
E
S
I
G
I
T
V
E
-----
K
S
W
-
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
I
Q
P
---
T
F
I
T
E
Y
P
A
E
V
S
P
L
A
R
R
N
D
V
N
P
E
-----
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
----------------------------------
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
60
HHSearch
91.02
50%
-70
- C6 -
1E1O
9
SYK2_ECOLI
A:
[11-501]
-----
A
I
--
D
F
N
D
E
L
R
N
--
R
R
E
K
L
A
A
L
R
Q
Q
G
V
-
A
F
P
N
D
F
R
R
D
H
T
S
D
Q
L
H
E
E
F
D
A
K
D
N
Q
E
L
E
S
L
N
I
E
V
S
V
A
G
R
M
M
T
R
R
I
M
G
-
K
-
A
S
F
V
T
L
Q
D
V
G
G
R
I
Q
L
Y
V
--
A
R
D
S
L
P
E
G
V
Y
N
D
Q
F
----
K
K
W
D
L
G
D
I
I
G
A
R
G
T
L
F
K
T
Q
T
G
E
L
S
I
H
C
T
E
L
R
L
L
T
K
A
L
R
P
L
P
D
-------
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
Q
V
I
P
G
G
A
S
A
R
P
F
I
T
H
H
N
A
L
D
L
D
M
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
S
V
-
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
D
Y
H
D
L
I
E
L
T
E
----
S
L
F
R
T
L
A
Q
E
V
L
----
G
T
T
K
-----
V
T
Y
G
E
H
V
F
D
F
G
K
P
F
E
K
L
T
M
R
E
A
I
K
K
Y
R
P
-
E
T
D
M
A
D
L
D
N
-----
F
D
A
A
K
--------
A
L
A
E
S
I
G
I
T
V
------
E
K
S
W
G
L
G
R
I
V
T
E
I
F
D
E
V
A
E
A
H
L
I
Q
P
---
T
F
I
T
E
Y
P
A
E
V
S
P
L
A
R
R
N
D
V
N
P
E
-----
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
----------------------------------
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
11
PsiBlast_PDB
88.24
49%
-67
- C6 -
4EX5
1
SYK_BURTA
A:
[36-526]
------------
E
N
Q
I
V
A
E
R
R
D
K
L
R
A
L
R
D
Q
G
I
-
A
Y
P
N
D
F
Q
P
T
H
H
A
A
D
L
Q
T
A
Y
A
D
A
D
K
E
A
L
E
A
K
S
L
E
V
A
I
A
G
R
M
M
L
K
R
V
M
G
-
K
-
A
S
F
A
T
V
Q
D
G
S
G
Q
I
Q
F
F
V
--
T
P
A
D
V
G
A
E
T
Y
-
D
A
F
----
K
K
W
D
L
G
D
I
V
A
A
R
G
V
L
F
R
T
N
K
G
E
L
S
V
K
C
T
Q
L
R
L
L
A
K
A
L
R
P
L
P
D
------
D
Q
E
T
R
Y
R
Q
R
Y
V
D
L
I
V
T
P
E
T
R
T
T
F
R
A
R
T
K
A
I
A
S
I
R
K
F
M
G
D
A
D
F
M
E
V
E
T
P
M
L
H
P
I
P
G
G
A
A
A
K
P
F
V
T
H
H
N
A
L
D
M
E
M
F
L
R
I
A
P
E
L
Y
L
K
R
L
I
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
V
S
P
R
H
N
P
E
F
T
M
M
E
F
Y
A
A
Y
T
D
Y
R
W
L
M
D
F
T
E
----
R
L
I
R
Q
A
A
V
D
A
L
----
G
T
A
T
-----
I
Q
Y
Q
G
R
E
L
D
L
A
Q
P
F
H
R
L
T
I
T
Q
A
I
Q
K
Y
A
P
-
S
Y
T
D
G
Q
L
-
S
D
D
A
F
L
R
S
E
L
K
--------
R
L
G
V
D
V
T
Q
P
A
F
-----
L
N
-
A
G
I
G
A
L
Q
L
A
L
F
E
E
T
A
E
A
Q
L
W
E
P
---
T
F
I
I
D
Y
P
I
E
V
S
P
L
A
R
E
S
D
T
V
A
G
-----
I
T
E
R
F
E
L
F
I
T
G
R
E
I
A
N
G
F
S
E
L
N
D
P
E
D
Q
A
A
R
F
K
K
Q
----------------------------------
V
E
Q
K
D
A
G
D
E
E
A
M
F
F
D
A
D
Y
I
R
A
L
E
Y
G
M
P
P
T
G
G
C
G
I
G
I
D
R
L
V
M
L
L
T
D
S
P
T
I
R
D
V
L
L
F
P
H
L
R
32
PsiBlast_CBE
88.13
49%
-68
- C6 -
4EX5
1
SYK_BURTA
B:
[35-526]
-----------
D
E
N
Q
I
V
A
E
R
R
D
K
L
R
A
L
R
D
Q
G
I
-
A
Y
P
N
D
F
Q
P
T
H
H
A
A
D
L
Q
T
A
Y
A
D
A
D
K
E
A
L
E
A
K
S
L
E
V
A
I
A
G
R
M
M
L
K
R
V
M
G
-
K
-
A
S
F
A
T
V
Q
D
G
S
G
Q
I
Q
F
F
V
--
T
P
A
D
V
G
A
E
T
Y
-
D
A
F
----
K
K
W
D
L
G
D
I
V
A
A
R
G
V
L
F
R
T
N
K
G
E
L
S
V
K
C
T
Q
L
R
L
L
A
K
A
L
R
P
L
P
D
-------
Q
E
T
R
Y
R
Q
R
Y
V
D
L
I
V
T
P
E
T
R
T
T
F
R
A
R
T
K
A
I
A
S
I
R
K
F
M
G
D
A
D
F
M
E
V
E
T
P
M
L
H
P
I
P
G
G
A
A
A
K
P
F
V
T
H
H
N
A
L
D
M
E
M
F
L
R
I
A
P
E
L
Y
L
K
R
L
I
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
V
S
P
R
H
N
P
E
F
T
M
M
E
F
Y
A
A
Y
T
D
Y
R
W
L
M
D
F
T
E
----
R
L
I
R
Q
A
A
V
D
A
L
----
G
T
A
T
-----
I
Q
Y
Q
G
R
E
L
D
L
A
Q
P
F
H
R
L
T
I
T
Q
A
I
Q
K
Y
A
P
-
S
Y
T
D
G
Q
L
-
S
D
D
A
F
L
R
S
E
L
K
--------
R
L
G
V
D
V
T
Q
P
A
F
-----
L
N
-
A
G
I
G
A
L
Q
L
A
L
F
E
E
T
A
E
A
Q
L
W
E
P
---
T
F
I
I
D
Y
P
I
E
V
S
P
L
A
R
E
S
D
T
V
A
G
-----
I
T
E
R
F
E
L
F
I
T
G
R
E
I
A
N
G
F
S
E
L
N
D
P
E
D
Q
A
A
R
F
K
K
Q
----------------------------------
V
E
Q
K
D
A
G
D
E
E
A
M
F
F
D
A
D
Y
I
R
A
L
E
Y
G
M
P
P
T
G
G
C
G
I
G
I
D
R
L
V
M
L
L
T
D
S
P
T
I
R
D
V
L
L
F
P
H
L
R
39
PsiBlast_CBE
85.44
42%
-56
- C6 -
4YCU
4
SYK_HUMAN
B:
[6-506]
-----------
N
Q
Y
Y
K
I
--
R
S
Q
A
I
H
Q
L
K
V
N
G
E
D
P
Y
P
H
K
F
H
V
D
I
S
L
T
D
F
I
Q
K
Y
S
H
L
Q
P
G
D
-
H
L
T
D
I
T
L
K
V
A
G
R
I
H
A
K
R
A
S
G
G
K
-
L
I
F
Y
D
L
R
G
E
G
V
K
L
Q
V
M
A
N
S
R
N
Y
K
S
E
E
E
F
I
-
H
I
N
----
N
K
L
R
R
G
D
I
I
G
V
Q
G
N
P
G
K
T
K
K
G
E
L
S
I
I
P
Y
E
I
T
L
L
S
P
C
L
H
M
L
P
H
L
-----
D
K
E
T
R
Y
R
Q
R
Y
L
D
L
I
L
N
D
F
V
R
Q
K
F
I
I
R
S
K
I
I
T
Y
I
R
S
F
L
D
E
L
G
F
L
E
I
E
T
P
M
M
N
I
I
P
G
G
A
V
A
K
P
F
I
T
Y
H
N
E
L
D
M
N
L
Y
M
R
I
A
P
E
L
Y
H
K
M
L
V
V
G
G
I
D
R
V
Y
E
I
G
R
Q
F
R
N
E
G
I
D
L
T
H
N
P
E
F
T
T
C
E
F
Y
M
A
Y
A
D
Y
H
D
L
M
E
I
T
E
K
M
V
S
G
M
V
K
H
I
T
G
S
Y
K
V
T
Y
H
P
D
G
P
------
E
G
Q
A
Y
D
V
D
F
T
P
P
F
R
R
I
N
M
V
E
E
L
E
K
A
L
G
-
M
K
L
P
E
T
N
-
L
-----
F
E
T
E
E
T
R
K
I
L
D
D
I
C
V
A
K
A
V
E
C
P
P
P
-----
R
---
T
T
A
R
L
L
D
K
L
V
G
E
F
L
E
V
T
C
I
N
P
---
T
F
I
C
D
H
P
Q
I
M
S
P
L
A
K
W
H
R
S
K
E
G
-----
L
T
E
R
F
E
L
F
V
M
K
K
E
I
C
N
A
Y
T
E
L
N
D
P
M
R
Q
R
Q
L
F
E
E
Q
----------------------------------
A
K
A
K
A
A
G
D
D
E
A
M
F
I
D
E
N
F
C
T
A
L
E
Y
G
L
P
P
T
A
G
W
G
M
G
I
D
R
V
A
M
F
L
T
D
S
N
N
I
K
E
V
L
L
F
P
A
M
K
15
PsiBlast_PDB
84.97
42%
-54
- C6 -
4YCU
4
SYK_HUMAN
A:
[6-506]
-----------
N
Q
Y
Y
K
I
--
R
S
Q
A
I
H
Q
L
K
V
N
G
E
D
P
Y
P
H
K
F
H
V
D
I
S
L
T
D
F
I
Q
K
Y
S
H
L
Q
P
G
D
-
H
L
T
D
I
T
L
K
V
A
G
R
I
H
A
K
R
A
S
G
G
K
-
L
I
F
Y
D
L
R
G
E
G
V
K
L
Q
V
M
A
NS
R
N
Y
K
S
E
E
E
F
I
-
H
I
N
----
N
K
L
R
R
G
D
I
I
G
V
Q
G
N
P
G
K
T
K
K
G
E
L
S
I
I
P
Y
E
I
T
L
L
S
P
C
L
H
M
L
P
H
L
H
F
G
L
K
D
K
E
T
R
Y
R
Q
R
Y
L
D
L
I
L
N
D
F
V
R
Q
K
F
I
I
R
S
K
I
I
T
Y
I
R
S
F
L
D
E
L
G
F
L
E
I
E
T
P
M
M
N
I
I
P
G
G
A
V
A
K
P
F
I
T
Y
H
N
E
L
D
M
N
L
Y
M
R
I
A
P
E
L
Y
H
K
M
L
V
V
G
G
I
D
R
V
Y
E
I
G
R
Q
F
R
N
E
G
I
D
L
T
H
N
P
E
F
T
T
C
E
F
Y
M
A
Y
A
D
Y
H
D
L
M
E
I
T
E
K
M
V
S
G
M
V
K
H
I
T
G
S
Y
K
V
T
Y
H
P
D
G
P
------
E
G
Q
A
Y
D
V
D
F
T
P
P
F
R
R
I
N
M
V
E
E
L
E
K
A
L
G
-
M
K
L
P
E
T
N
-
L
-----
F
E
T
E
E
T
R
K
I
L
D
D
I
C
V
A
K
A
V
E
C
P
P
P
-----
R
---
T
T
A
R
L
L
D
K
L
V
G
E
F
L
E
V
T
C
I
N
P
---
T
F
I
C
D
H
P
Q
I
M
S
P
L
A
K
W
H
R
S
K
E
G
-----
L
T
E
R
F
E
L
F
V
M
K
K
E
I
C
N
A
Y
T
E
L
N
D
P
M
R
Q
R
Q
L
F
E
E
Q
----------------------------------
A
K
A
K
A
A
G
D
D
E
A
M
F
I
D
E
N
F
C
T
A
L
E
Y
G
L
P
P
T
A
G
W
G
M
G
I
D
R
V
A
M
F
L
T
D
S
N
N
I
K
E
V
L
L
F
P
A
M
K
20
PsiBlast_PDB
75.66
35%
-67
- C6 -
4UPA
1
?
A:
[28-568]
------------------------------
G
H
N
P
W
P
H
K
F
N
V
S
I
T
V
P
E
F
I
A
K
Y
S
G
L
E
K
S
Q
V
S
D
--
D
I
V
S
V
A
G
R
V
L
S
K
R
S
S
S
-
S
A
L
M
F
I
D
L
H
D
S
Q
T
K
L
Q
I
M
L
--
N
K
S
A
Y
--
E
N
K
-
E
D
F
V
S
L
T
K
M
I
Y
R
G
D
I
C
G
F
T
G
H
P
T
R
T
K
T
G
E
L
S
L
I
P
I
S
G
M
I
L
S
P
C
L
H
M
L
P
S
M
H
Y
G
L
G
D
Q
E
T
R
F
R
K
R
Y
L
D
L
I
V
N
P
E
S
V
K
N
F
V
L
R
T
K
V
V
K
A
V
R
K
Y
L
D
D
K
G
F
L
E
V
E
T
P
I
L
N
T
I
P
G
G
A
T
A
R
P
F
I
T
H
H
N
Q
L
D
I
Q
M
Y
M
R
I
A
P
E
L
Y
L
K
E
L
V
V
G
G
I
N
R
V
Y
E
I
G
R
L
F
R
N
E
G
I
D
Q
T
H
N
P
E
F
T
T
C
E
F
Y
M
A
Y
A
D
Y
N
D
I
M
K
M
T
E
----
E
L
L
G
N
M
V
K
D
I
T
----
G
G
S
T
K
L
E
I
K-------------------------------------------------------------
K
K
M
V
L
D
FTAP
F
K
R
I
S
Y
V
-
H
A
L
E
E
K
F
G
E
K
I
P
R
P
L
D
G
P
E
A
L
T
F
L
K
K
Q
A
I
R
F
N
A
I
C
A
E
P
Q
T
T
A
R
V
M
D
K
L
F
G
D
L
I
E
V
D
L
V
Q
P
T
F
V
C
D
Q
P
Q
L
M
S
P
L
A
K
Y
H
R
S
E
P
E
L
T
E
R
F
E
L
F
I
LKREI
A
N
A
Y
TELNN
P
I
V
Q
R
S
N
F
E
Q
Q
A
K
D
K
A
-------
L
V
D
E
V
F
L
D
A
I
E
H
A
F
P
P
T
G
G
W
G
L
G
I
D
R
L
A
M
L
L
A
D
V
D
N
I
K
E
V
I
L
F
P
T
M
R
19
PsiBlast_PDB
73.82
35%
-66
- C6 -
4UP9
1
?
A:
[28-568]
------------------------------
G
H
N
P
W
P
H
K
F
N
V
S
I
T
V
P
E
F
I
A
K
Y
S
G
L
E
K
S
Q
V
S
D
--
D
I
V
S
V
A
G
R
V
L
S
K
R
S
S
S
-
S
A
L
M
F
I
D
L
H
D
S
Q
T
K
L
Q
I
M
L
--
N
K
S
A
Y
--
E
N
K
-
E
D
F
V
S
L
T
K
M
I
Y
R
G
D
I
C
G
F
T
G
H
P
T
R
T
K
T
G
E
L
S
L
I
P
I
S
G
M
I
L
S
P
C
L
H
M
L
P
S
M
H
Y
G
L
G
D
Q
E
T
R
F
R
K
R
Y
L
D
L
I
V
N
P
E
S
V
K
N
F
V
L
R
T
K
V
V
K
A
V
R
K
Y
L
D
D
K
G
F
L
E
V
E
T
P
I
L
N
T
I
P
G
G
A
T
A
R
P
F
I
T
H
H
N
Q
L
D
I
Q
M
Y
M
R
I
A
P
E
L
Y
L
K
E
L
V
V
G
G
I
N
R
V
Y
E
I
G
R
L
F
R
N
E
G
I
D
Q
T
H
N
P
E
F
T
T
C
E
F
Y
M
A
Y
A
D
Y
N
D
I
M
K
M
T
E
----
E
L
L
G
N
M
V
K
D
I
T
----
G
G
S
T
K
L
E
IK--------------------------------------------------------------
K
M
V
L
D
FTAP
F
K
R
I
S
Y
V
-
H
A
L
E
E
K
F
G
E
K
I
P
R
P
L
D
G
P
E
A
L
T
F
L
K
K
Q
A
I
R
F
N
A
I
C
A
E
P
Q
T
T
A
R
V
M
D
K
L
F
G
D
L
I
E
V
D
L
V
Q
P
T
F
V
C
D
Q
P
Q
L
M
S
P
L
A
K
Y
H
R
S
E
P
E
L
T
E
R
F
E
L
F
I
LKREI
A
N
A
Y
TELNN
P
I
V
Q
R
S
N
F
E
Q
Q
A
K
D
K
A
-------
L
V
D
E
V
F
L
D
A
I
E
H
A
F
P
P
T
G
G
W
G
L
G
I
D
R
L
A
M
L
L
A
D
V
D
N
I
K
E
V
I
L
F
P
T
M
R
17
PsiBlast_PDB
73.38
35%
-61
- C6 -
4UP7
1
?
A:
[28-568]
------------------------------
G
H
N
P
W
P
H
K
F
N
V
S
I
T
V
P
E
F
I
A
K
Y
S
G
L
E
K
S
Q
V
S
D
--
D
I
V
S
V
A
G
R
V
L
S
K
R
S
S
S
-
S
A
L
M
F
I
D
L
H
D
S
Q
T
K
L
Q
I
M
L
--
N
K
S
A
Y
--
E
N
K
-
E
D
F
V
S
L
T
K
M
I
Y
R
G
D
I
C
G
F
T
G
H
P
T
R
T
K
T
G
E
L
S
L
I
P
I
S
G
M
I
L
S
P
C
L
H
M
L
P
S
M
H
Y
G
L
G
D
Q
E
T
R
F
R
K
R
Y
L
D
L
I
V
N
P
E
S
V
K
N
F
V
L
R
T
K
V
V
K
A
V
R
K
Y
L
D
D
K
G
F
L
E
V
E
T
P
I
L
N
T
I
P
G
G
A
T
A
R
P
F
I
T
H
H
N
Q
L
D
I
Q
M
Y
M
R
I
A
P
E
L
Y
L
K
E
L
V
V
G
G
I
N
R
V
Y
E
I
G
R
L
F
R
N
E
G
I
D
Q
T
H
N
P
E
F
T
T
C
E
F
Y
M
A
Y
A
D
Y
N
D
I
M
K
M
T
E
----
E
L
L
G
N
M
V
K
D
I
T
----
G
G
S
T
K
L
E
I
K---------------------------------------------------------
F
V
T
E
K
K
M
V
L
D
FTAP
F
K
R
I
S
Y
V
-
H
A
L
E
E
K
F
G
E
K
I
P
R
P
L
D
G
P
E
A
L
T
F
L
K
K
Q
A
I
R
F
N
A
I
C
A
E
P
Q
T
T
A
R
V
M
D
K
L
F
G
D
L
I
E
V
D
L
V
Q
P
T
F
V
C
D
Q
P
Q
L
M
S
P
L
A
K
Y
H
R
S
E
P
E
LTE
R
F
E
L
F
I
LKREI
A
N
A
Y
TELNN
P
I
V
Q
R
S
N
F
E
Q
Q
A
K
D
K
A
A
G
D
D
E
A
Q
L
V
D
E
V
F
L
D
A
I
E
H
A
F
P
P
T
G
G
W
G
L
G
I
D
R
L
A
M
L
L
A
D
V
D
N
I
K
E
V
I
L
F
P
T
M
R