@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1086: (2015-12-05 )
MGYTVAIVGATGAVGTQMIRQLEQSNLPIEQVKLLSSSRSAGKILHFKDEAIRVEETTKESFYDVDIALFSAGGSISAKFAPYAVKSGAVVVDNTSYFRQNPDVPLVVPEVNAHAMIGHNGIIACPNCSTIQMMIALEPIRQKWGIERVIVSTYQAVSGSGARAVEETKEQLRQVLNDNLSPDQLIATVLPCSSDQKHYPIAFNALPQIDIFTDNDYTYEEMKMTLETKKIMEDATIKVSATCVRIPVLSGHSESIYIETKELASISEIKKAIANFPGAVLQDLPSQQIYPQAINAVGHRETFVGRIRKDLDQENGVHMWVVSDNLLKGAAWNSVQIAETLHKNGLVKPAKELKFELI
Atome Classification :
(32 SA)
.........10........20........30.......-.40.......-----.50------........--.60........70........80........90........100.......110----......----------.120.......130.......140.......150.......160.......170.......180....----...190.......200.......210.--....--..220.......230...--------....240.......250.......260.......270.......280...---.------...290..-.--....300.......310..--.......320.......330.......340.......350......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
G
Y
T
V
A
I
VGAT
G
A
V
G
T
Q
M
I
R
Q
L
E
Q
SNL
P
I
E
Q
V
K
L
L
SSS-RSA
G
K
I
L
H
FK-----DE-------
A
I
R
V
E
ETT--KES
F
Y
D
V
D
I
A
L
F
SAGGSISAKFA
P
Y
A
VKS
G
A
V
V
VDN
T
S
Y
FRQNPDV
P
L
V
V
PEVN----
A
H
A
M
IG----------HN
G
I
I
ACPNC
S
T
I
Q
M
M
I
A
L
E
P
I
R
Q
KWG
I
E
R
V
I
V
S
T
Y
Q
AVSGSGA
R
A
V
E
E
T
K
E
Q
L
R
Q
V
L
NDNL
S
P
D
Q
L
I
----
A
T
VLPCSSDQKHY
P
I
A
FNALP
Q
I
D
I
F
T--DNDY--
T
Y
E
E
M
K
M
T
L
E
T
K
K
IMEDA--------
T
I
K
V
S
A
T
C
V
R
I
P
VLSGHS
E
S
I
Y
I
E
T
K
E
L
A
S
I
S
E
I
K
K
A
I
ANF
P
G
A
V
L
QDLP---S------QQI
Y
P
Q
A
I
-
N
--AVGH
R
E
T
F
V
G
R
I
R
K
D
--LD--QEN
G
V
H
M
W
V
VSDNLLKGAAWN
S
V
Q
I
A
E
T
L
H
KNGLVK
P
A
K
E
L
K
FELI
16
PsiBlast_PDB
99.11
75%
-98
- C2 -
4R51
13
?
A:
[2-357]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
----
A
H
A
L
D
A
----------
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
P
C
D
L
H
----
A
E
I
L
P
S
G
G
D
K
K
H
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
------
H
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
--
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
P
T
A
E
L
K
F
E
L
K
22
PsiBlast_CBE
98.86
75%
-99
- C2 -
4R54
4
?
B:
[2-357]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
----
A
H
A
L
D
A
----------
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
P
C
D
L
H
----
A
E
I
L
P
S
G
G
D
K
K
H
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
------
H
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
--
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
P
T
A
E
L
K
F
E
L
K
24
PsiBlast_CBE
98.75
75%
-98
- C2 -
4R4J
7
?
B:
[2-357]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
----
A
H
A
L
D
A
----------
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
P
C
D
L
H
----
A
E
I
L
P
S
G
G
D
K
K
H
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
------
H
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
--
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
P
T
A
E
L
K
F
E
L
K
18
PsiBlast_PDB
98.73
75%
-96
- C2 -
4R5H
9
?
A:
[2-357]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
----
A
H
A
L
D
A
----------
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
P
C
D
L
H
----
A
E
I
L
P
S
G
G
D
K
K
H
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
------
H
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
--
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
P
T
A
E
L
K
F
E
L
K
14
PsiBlast_PDB
98.53
75%
-97
- C2 -
4R41
11
?
A:
[2-357]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
----
A
H
A
L
D
A
----------
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
P
C
D
L
H
----
A
E
I
L
P
S
G
G
D
K
K
H
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
------
H
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
--
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
P
T
A
E
L
K
F
E
L
K
10
PsiBlast_PDB
98.52
75%
-95
- C2 -
3Q11
6
?
A:
[2-357]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
----
A
H
A
L
D
A
----------
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
P
C
D
L
H
----
A
E
I
L
P
S
G
G
D
K
K
H
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
------
H
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
--
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
P
T
A
E
L
K
F
E
L
K
32
PsiBlast_CBE
98.49
75%
-98
- C2 -
3PZB
5
?
B:
[2-357]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
----
A
H
A
L
D
A
----------
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
P
C
D
L
H
----
A
E
I
L
P
S
G
G
D
K
K
H
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
------
H
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
--
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
P
T
A
E
L
K
F
E
L
K
37
PsiBlast_CBE
98.37
75%
-97
- C2 -
3PWK
8
?
B:
[2-357]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
----
A
H
A
L
D
A
----------
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
P
C
D
L
H
----
A
E
I
L
P
S
G
G
D
K
K
H
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
------
H
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
--
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
P
T
A
E
L
K
F
E
L
K
21
PsiBlast_CBE
98.31
75%
-97
- C2 -
4R5H
6
?
B:
[2-357]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
----
A
H
A
L
D
A
----------
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
P
C
D
L
H
----
A
E
I
L
P
S
G
G
D
K
K
H
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
------
H
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
--
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
P
T
A
E
L
K
F
E
L
K
12
PsiBlast_PDB
98.22
75%
-96
- C2 -
4R3N
8
?
A:
[2-357]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
----
A
H
A
L
D
A
----------
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
P
C
D
L
H
----
A
E
I
L
P
S
G
G
D
K
K
H
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
------
H
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
--
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
P
T
A
E
L
K
F
E
L
K
8
PsiBlast_PDB
98.18
75%
-95
- C2 -
3PYX
6
?
A:
[2-357]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
----
A
H
A
L
D
A
----------
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
P
C
D
L
H
----
A
E
I
L
P
S
G
G
D
K
K
H
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
------
H
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
--
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
P
T
A
E
L
K
F
E
L
K
36
PsiBlast_CBE
98.16
75%
-96
- C2 -
3PWS
2
?
B:
[2-357]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
----
A
H
A
L
D
A
----------
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
P
C
D
L
H
----
A
E
I
L
P
S
G
G
D
K
K
H
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
------
H
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
--
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
P
T
A
E
L
K
F
E
L
K
3
PsiBlast_PDB
98.13
75%
-100
- C2 -
2GZ2
1
?
A:
[2-357]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
----
A
H
A
L
D
A
----------
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
P
C
D
L
H
----
A
E
I
L
P
S
G
G
D
K
K
H
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
------
H
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
--
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
P
T
A
E
L
K
F
E
L
K
29
PsiBlast_CBE
98.12
75%
-98
- C2 -
3Q1L
1
?
C:
[2-357]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
----
A
H
A
L
D
A
----------
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
P
C
D
L
H
----
A
E
I
L
P
S
G
G
D
K
K
H
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
------
H
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
--
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
P
T
A
E
L
K
F
E
L
K
33
PsiBlast_CBE
98.08
75%
-93
- C2 -
3PYX
6
?
B:
[2-357]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
----
A
H
A
L
D
A
----------
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
P
C
D
L
H
----
A
E
I
L
P
S
G
G
D
K
K
H
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
------
H
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
--
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
P
T
A
E
L
K
F
E
L
K
34
PsiBlast_CBE
98.00
75%
-97
- C2 -
3PYL
1
?
C:
[2-357]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
----
A
H
A
L
D
A
----------
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
P
C
D
L
H
----
A
E
I
L
P
S
G
G
D
K
K
H
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
------
H
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
--
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
P
T
A
E
L
K
F
E
L
K
2
PsiBlast_PDB
98.00
75%
-95
- C2 -
2GZ1
1
?
A:
[2-357]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
----
A
H
A
L
D
A
----------
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
P
C
D
L
H
----
A
E
I
L
P
S
G
G
D
K
K
H
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
------
H
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
--
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
P
T
A
E
L
K
F
E
L
K
17
PsiBlast_PDB
97.96
75%
-96
- C2 -
4R54
5
?
A:
[2-357]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
----
A
H
A
L
D
A
----------
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
P
C
D
L
H
----
A
E
I
L
P
S
G
G
D
K
K
H
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
------
H
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
--
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
P
T
A
E
L
K
F
E
L
K
5
PsiBlast_PDB
97.95
75%
-98
- C2 -
3PWK
8
?
A:
[2-357]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
----
A
H
A
L
D
A
----------
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
P
C
D
L
H
----
A
E
I
L
P
S
G
G
D
K
K
H
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
------
H
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
--
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
P
T
A
E
L
K
F
E
L
K
6
PsiBlast_PDB
97.90
75%
-98
- C2 -
3PWS
3
?
A:
[2-357]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
----
A
H
A
L
D
A
----------
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
P
C
D
L
H
----
A
E
I
L
P
S
G
G
D
K
K
H
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
------
H
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
--
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
P
T
A
E
L
K
F
E
L
K
15
PsiBlast_PDB
97.87
75%
-92
- C2 -
4R4J
7
?
A:
[2-357]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
----
A
H
A
L
D
A
----------
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
P
C
D
L
H
----
A
E
I
L
P
S
G
G
D
K
K
H
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
------
H
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
--
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
P
T
A
E
L
K
F
E
L
K
31
PsiBlast_CBE
97.76
75%
-97
- C2 -
3Q11
5
?
B:
[2-357]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
----
A
H
A
L
D
A
----------
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
P
C
D
L
H
----
A
E
I
L
P
S
G
G
D
K
K
H
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
------
H
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
--
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
P
T
A
E
L
K
F
E
L
K
13
PsiBlast_PDB
97.67
75%
-96
- C2 -
4R3W
8
?
A:
[2-357]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
----
A
H
A
L
D
A
----------
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
P
C
D
L
H
----
A
E
I
L
P
S
G
G
D
K
K
H
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
------
H
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
--
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
P
T
A
E
L
K
F
E
L
K
9
PsiBlast_PDB
97.55
75%
-98
- C2 -
3PZB
6
?
A:
[2-357]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
----
A
H
A
L
D
A
----------
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
P
C
D
L
H
----
A
E
I
L
P
S
G
G
D
K
K
H
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
------
H
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
--
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
P
T
A
E
L
K
F
E
L
K
23
PsiBlast_CBE
97.52
75%
-99
- C2 -
4R51
8
?
B:
[2-348]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
----
A
H
A
L
D
A
----------
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
P
C
D
L
H
----
A
E
I
L
P
S
G
G
D
K
K
H
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
------
H
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
--
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
----------
26
PsiBlast_CBE
97.23
75%
-99
- C2 -
4R3W
8
?
B:
[2-348]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
----
A
H
A
L
D
A
----------
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
P
C
D
L
H
----
A
E
I
L
P
S
G
G
D
K
K
H
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
------
H
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
--
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
----------
27
PsiBlast_CBE
97.16
75%
-100
- C2 -
4R3N
10
?
B:
[2-348]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
----
A
H
A
L
D
A
----------
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
P
C
D
L
H
----
A
E
I
L
P
S
G
G
D
K
K
H
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
------
H
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
--
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
----------
25
PsiBlast_CBE
96.43
75%
-97
- C2 -
4R41
8
?
B:
[2-348]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
----
A
H
A
L
D
A
----------
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
P
C
D
L
H
----
A
E
I
L
P
S
G
G
D
K
K
H
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
D
--------
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
------
H
Q
I
Y
P
Q
A
I
-
N
--
A
V
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
--
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
L
V
R
----------
44
PsiBlast_CBE
74.01
38%
-81
- C2 -
3TZ6
10
DHAS_MYCTU
A:
[1-342]
-
G
L
S
I
G
I
V
G
A
T
G
Q
V
G
Q
V
M
R
T
L
L
D
E
R
D
F
P
A
S
A
V
R
F
F
A
S
A
-
R
S
Q
G
R
K
L
A
F
R
-----
G
Q
-------
E
I
E
V
E
D
A
E
--
T
A
D
P
S
G
L
D
I
A
L
F
S
A
G
S
A
M
S
K
V
Q
A
P
R
F
A
A
A
G
V
T
V
I
D
N
S
S
A
W
R
K
D
P
D
V
P
L
V
V
S
E
V
N
FERD
A
H
R
R
------------
P
K
G
I
I
A
N
P
N
C
T
T
M
A
A
M
P
V
L
K
V
L
H
D
E
A
R
L
V
R
L
V
V
S
S
Y
Q
A
V
S
G
S
G
L
A
G
V
A
E
L
A
E
Q
A
R
A
V
I
G
---
G
A
E
Q
L
V
YDGG
A
L
E
F
P
-
P
P
N
T
Y
V
A
P
I
A
F
N
V
V
P
L
A
G
S
L
V
--
D
D
G
S
GE
T
D
E
D
Q
K
L
R
F
E
S
R
K
I
L
G
I
P
--------
D
L
L
V
S
G
T
C
V
R
V
P
V
F
T
G
H
S
L
S
I
N
A
E
F
A
Q
P
L
S
P
E
R
A
R
E
L
L
D
G
A
T
G
V
Q
L
V
D
V
P
---
T
------
P
------
L
-
A
--
A
A
G
V
D
E
S
L
V
G
R
I
R
R
D
PG
V
P
--
D
G
R
G
L
A
L
F
V
S
G
D
N
L
R
K
G
A
A
L
N
T
I
Q
I
A
E
L
L
T
A
---------------
43
PsiBlast_CBE
73.40
38%
-81
- C2 -
3VOS
9
DHAS_MYCTU
A:
[19-359]
-
G
L
S
I
G
I
V
G
A
T
G
Q
V
G
Q
V
M
R
T
L
L
D
E
R
D
F
P
A
S
A
V
R
F
F
A
S
A
-
R
----
K
L
A
F
R
-----
G
Q
-------
E
I
E
V
E
D
A
E
--
T
A
D
P
S
G
L
D
I
A
L
F
S
A
G
S
A
M
S
K
V
Q
A
P
R
F
A
A
A
G
V
T
V
I
D
N
S
S
A
W
R
K
D
P
D
V
P
L
V
V
S
E
V
N
FERD
A
H
R
R
------------
P
K
G
I
I
A
N
P
N
C
T
T
M
A
A
M
P
V
L
K
V
L
H
D
E
A
R
L
V
R
L
V
V
S
S
Y
Q
A
V
S
G
S
G
L
A
G
V
A
E
L
A
E
Q
A
R
A
V
I
G
---
G
A
E
Q
L
V
YDGG
A
L
E
F
P
-
P
P
N
T
Y
V
A
P
I
A
F
N
V
V
P
L
A
G
S
L
V
--
D
D
G
S
GE
T
D
E
D
Q
K
L
R
F
E
S
R
K
I
L
G
I
P
--------
D
L
L
V
S
G
T
C
V
R
V
P
V
F
T
G
H
S
L
S
I
N
A
E
F
A
Q
P
L
S
P
E
R
A
R
E
L
L
D
G
A
T
G
V
Q
L
V
D
V
P
---
T
------
P
------
L
-
A
--
A
A
G
V
D
E
S
L
V
G
R
I
R
R
D
PG
V
P
--
D
G
R
G
L
A
L
F
V
S
G
D
N
L
R
K
G
A
A
L
N
T
I
Q
I
A
E
L
L
T
----------------
48
HHSearch
72.41
39%
-79
- C2 -
3TZ6
10
DHAS_MYCTU
A:
[1-342]
-
G
L
S
I
G
I
V
G
A
T
G
Q
V
G
Q
V
M
R
T
L
L
D
E
R
D
F
P
A
S
A
V
R
F
F
A
S
A
-
R
S
Q
G
R
K
L
A
F
R
-----
G
Q
-------
E
I
E
V
E
D
A
E
--
T
A
D
P
S
G
L
D
I
A
L
F
S
A
G
S
A
M
S
K
V
Q
A
P
R
F
A
A
A
G
V
T
V
I
D
N
S
S
A
W
R
K
D
P
D
V
P
L
V
V
S
E
V
N
----
F
E
R
D
A
H
RR--------
P
K
G
I
I
A
N
P
N
C
T
T
M
A
A
M
P
V
L
K
V
L
H
D
E
A
R
L
V
R
L
V
V
S
S
Y
Q
A
V
S
G
S
G
L
A
G
V
A
E
L
A
E
Q
A
R
A
V
I
G
G
A
E
Q
L
V
Y
D
G
----
G
A
L
E
F
P
P
P
N
T
Y
V
A
P
I
A
F
N
V
V
P
L
A
G
S
L
V
DD
G
S
G
E
--
T
D
E
D
Q
K
L
R
F
E
S
R
K
I
L
G
I
P
--------
D
L
L
V
S
G
T
C
V
R
V
P
V
F
T
G
H
S
L
S
I
N
A
E
F
A
Q
P
L
S
P
E
R
A
R
E
L
L
D
G
A
T
G
V
Q
L
V
D
---------------
V
P
T
P
L
-
A
--
A
A
G
V
D
E
S
L
V
G
R
I
R
R
D
--
P
G
VP
D
G
R
G
L
A
L
F
V
S
G
D
N
L
R
K
G
A
A
L
N
T
I
Q
I
A
E
L
L
T
A
---------------
59
HHSearch
70.09
39%
-78
- C2 -
1YS4
4
DHAS_METJA
A:
[7-354]
M
K
I
K
V
G
V
L
G
A
T
G
S
V
G
Q
R
F
V
Q
L
L
A
D
--
H
P
M
F
E
L
T
A
L
A
A
S
E
R
S
A
G
K
K
Y
K
D
A
C
YWFQ
D
R
DIPENIK
D
M
V
V
I
P
T
D
PK
H
E
E
F
E
D
V
D
I
V
F
S
A
L
P
S
D
L
A
K
K
F
E
P
E
F
A
K
E
G
K
L
I
F
S
N
A
S
A
Y
R
M
E
E
D
V
P
L
V
I
P
E
V
N
----
A
D
H
L
E
L
I
E
I
Q
R
E
K
RGW
D
G
A
I
I
T
N
P
N
C
S
T
I
C
A
V
I
T
L
K
P
I
M
D
K
F
G
L
E
A
V
F
I
A
T
M
Q
A
V
S
G
A
G
Y
N
G
V
P
S
-----------------------------------
M
A
I
L
D
N
L
I
P
F
I
K
N
------------
E
E
E
K
M
Q
T
E
S
L
K
L
L
G
T
L
K
DGKVELA
N
F
K
I
S
A
S
C
N
R
V
A
V
I
D
G
H
T
E
S
I
F
V
K
T
K
E
G
A
E
P
E
E
I
K
E
V
M
D
K
F
D
P
L
K
D
L
N
L
P
TYA
K
P
I
V
I
R
E
E
I
D
R
P
Q
P
R
L
D
RN
E
G
N
G
M
S
I
V
V
G
R
I
R
K
D
--
P
I
----
F
D
V
K
Y
T
A
L
E
H
N
T
I
R
G
A
A
G
A
S
V
L
N
A
E
Y
F
V
K
K
Y
I
------------