@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1408: (2015-12-07 )
MAYIWSYLKRYPNWLWLDLLGAMLFVTVILGMPTALAGMIDNGVTKGDRTGVYLWTFIMFIFVVLGIIGRITMAYASSRLTTTMIRDMRNDMYAKLQEYSHHEYEQIGVSSLVTRMTSDTFVLMQFAEMSLRLGLVTPMVMIFSVVMILITSPSLAWLVAVAMPLLVGVVLYVAIKTKPLSERQQTMLDKINQYVRENLTGLRVVRAFARENFQSQKFQVANQRYTDTSTGLFKLTGLTEPLFVQIIIAMIVAIVWFALDPLQRGAIKIGDLVAFIEYSFHALFSFLLFANLFTMYPRMVVSSHRIREVMDMPISINPNAEGVTDTKLKGHLEFDNVTFAYPGETESPVLHDISFKAKPGETIAFIGSTGSGKSSLVNLIPRFYDVTLGKILVDGVDVRDYNLKSLRQKIGFIPQKALLFTGTIGENLKYGKADATIDDLRQAVDISQAKEFIESHQEAFETHLAEGGSNLSGGQKQRLSIARAVVKDPDLYIFDDSFSALDYKTDATLRARLKEVTGDSTVLIVAQRVGTIMDADQIIVLDEGEIVGRGTHAQLIENNAIYREIAESQLKNQNLSEGE
Atome Classification :
(24 SA)
---.........10........20........--30.-------------.......40.......--.---50.......---.60--........70..-......80........90........100.......110.......120------.........130.......140.......150.......160.......170.......180.......190.......200.......210......--------.220...-----....230.......240.......250...-----...------.260.......270.-......280.....--.-.290.......300.......310....------...320----.--...-...-330.......340.......350.......360.......370.......380.....---.---.390.......400.......410.......420.......430..-.---.-....440-........450.......460.......470.......480.......490.......500.......-510.....--..520.........530.......540.......550.....--.--.560.......570.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---
M
A
Y
I
W
S
Y
L
K
RYPN
W
L
W
L
D
L
L
G
A
M
L
F
V
T
V
I
--LG
M
-------------
P
T
A
L
A
G
M
I
DNGVTKGD--R---T
G
V
Y
L
W
T
F
I
---
M
F
I
--
F
V
V
L
G
I
I
G
R
I
T
M
-
A
Y
ASS
R
L
T
T
T
M
I
R
D
M
R
N
D
M
Y
A
K
L
Q
E
YSH
H
E
Y
E
Q
I
G
V
S
S
L
V
T
R
MTS
D
T
--------
F
V
L
M
Q
F
A
E
M
S
L
RL
G
L
V
T
P
M
V
M
I
F
S
V
V
M
I
L
ITS
P
S
L
A
W
L
V
A
V
A
M
P
L
L
V
G
V
V
L
Y
V
A
IKTKP
L
S
E
R
Q
Q
T
M
L
D
K
I
N
Q
Y
V
R
E
NL
T
G
L
R
V
V
R
A
F
A
R
ENFQS
Q
K
F
--------
Q
VANQRY-----TDTSTG
L
F
K
LTGLT
E
P
L
F
V
Q
I
I
I
A
M
I
V
A
I
V
-----
W
F
A
------L
D
P
L
QRGAI
K
I
G
D
L
V
-
A
F
I
E
Y
S
F
H
A
L
F
S
F
L
--
L
-
F
A
N
L
F
T
M
Y
P
R
M
V
V
S
S
H
R
I
R
E
V
MDM
P
I
SI------NPNAEG----V--TDT-
K
L
K
-
G
H
L
E
FD
N
V
T
F
AYPGETES
P
V
L
H
D
I
S
FKAKPG
E
T
I
A
F
IGSTGS
G
K
S
S
L
V
N
L
I
P
R
F
Y
D
V
T
---
L
---
G
K
I
L
VDGVDVRDY
N
L
K
S
L
R
Q
K
IGFIPQ
K
A
L
L
F
TGTIGENLKYG-KA-D---A-
T
I
D
D
L
R
--
Q
A
V
D
I
S
Q
A
K
E
F
I
E
S
H
Q
E
A
F
E
T
H
L
A
EGGSNLSGG
Q
K
Q
R
L
S
I
A
R
A
VVKDP
D
L
Y
I
FDDSFSALDYKT
D
A
T
L
-
R
A
R
L
K
E
VT--GD
S
--
T
V
L
I
V
A
Q
RVGTIMDA
D
Q
I
I
V
LDEG
E
I
VGRGT
H
A
Q
L
IE--N--
N
A
I
Y
R
E
I
A
E
S
Q
LKNQNLSEGE
3
PsiBlast_PDB
92.66
36%
-121
- C1 -
4Q4A
2
?
A:
[17-579]
---------
Y
L
K
--
P
Y
W
I
F
A
V
L
A
P
L
F
M
V
V
E
V
I
C
D
L
S
Q
-------------
P
T
L
L
A
R
I
V
D
E
G
I
A
R
G
D
--
F
---
S
L
V
L
K
T
G
I
L
---
M
L
I
--
V
A
L
I
G
A
V
G
G
I
G
C
-
T
V
F
A
S
Y
A
S
Q
N
F
G
A
D
L
R
R
D
L
F
R
K
V
L
S
F
S
I
S
N
V
N
R
F
H
T
S
S
L
I
T
R
L
T
N
D
V
--------
T
Q
L
Q
N
L
V
M
M
L
L
R
I
V
V
R
A
P
L
L
F
V
G
G
I
V
M
A
V
S
I
N
V
K
L
S
S
V
L
I
F
L
I
P
P
I
V
L
L
F
V
W
L
T
K
K
G
N
P
L
F
R
K
I
Q
E
S
T
D
E
V
N
R
V
V
R
E
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
E
N
E
N
F
--------
R
K
A
N
E
S
L
-----
R
R
S
I
I
S
A
F
S
L
I
V
F
A
L
P
L
F
I
F
I
V
N
M
G
M
I
A
V
L
-----
W
F
G
------
G
V
L
V
R
N
N
Q
M
E
I
G
S
I
M
-
A
Y
T
N
Y
L
M
Q
I
M
F
S
L
M
--
M
-
I
G
N
I
L
N
F
I
V
R
A
S
A
S
A
K
R
V
L
E
V
L
N
E
K
P
A
I
------
E
E
A
D
N
A
----
L
--
A
L
P
-
N
V
E
-
G
S
V
S
F
E
N
V
E
F
R
Y
-
F
E
N
T
D
P
V
L
S
G
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
---
R
---
G
R
V
E
V
D
E
L
D
V
R
T
V
K
L
K
D
L
R
G
H
I
S
A
V
P
Q
E
T
V
L
F
S
G
T
I
K
E
N
L
K
W
G
-
R
E
-
D
---
A
-
T
D
D
E
I
V
--
E
A
A
K
I
A
Q
I
H
D
F
I
I
S
L
P
E
G
Y
D
S
R
V
E
R
G
G
R
N
F
S
G
G
Q
K
Q
R
L
S
I
A
R
A
L
V
K
K
P
K
V
L
I
L
D
D
C
T
S
S
V
D
P
I
T
E
K
R
I
-
L
D
G
L
K
R
Y
T
--
K
G
C
--
T
T
F
I
I
T
Q
K
I
P
T
A
L
L
A
D
K
I
L
V
L
H
E
G
K
V
A
G
F
G
T
H
K
E
L
L
E
--
H
--
C
K
P
Y
R
E
I
Y
E
S
Q
F
---------
2
PsiBlast_PDB
92.17
36%
-121
- C1 -
3QF4
2
?
A:
[17-579]
---------
Y
L
K
--
P
Y
W
I
F
A
V
L
A
P
L
F
M
V
V
E
V
I
C
D
L
S
Q
-------------
P
T
L
L
A
R
I
V
D
E
G
I
A
R
G
D
--
F
---
S
L
V
L
K
T
G
I
L
---
M
L
I
--
V
A
L
I
G
A
V
G
G
I
G
C
-
T
V
F
A
S
Y
A
S
Q
N
F
G
A
D
L
R
R
D
L
F
R
K
V
L
S
F
S
I
S
N
V
N
R
F
H
T
S
S
L
I
T
R
L
T
N
D
V
--------
T
Q
L
Q
N
L
V
M
M
L
L
R
I
V
V
R
A
P
L
L
F
V
G
G
I
V
M
A
V
S
I
N
V
K
L
S
S
V
L
I
F
L
I
P
P
I
V
L
L
F
V
W
L
T
K
K
G
N
P
L
F
R
K
I
Q
E
S
T
D
E
V
N
R
V
V
R
E
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
E
N
E
N
F
--------
R
K
A
N
E
S
L
-----
R
R
S
I
I
S
A
F
S
L
I
V
F
A
L
P
L
F
I
F
I
V
N
M
G
M
I
A
V
L
-----
W
F
G
------
G
V
L
V
R
N
N
Q
M
E
I
G
S
I
M
-
A
Y
T
N
Y
L
M
Q
I
M
F
S
L
M
--
M
-
I
G
N
I
L
N
F
I
V
R
A
S
A
S
A
K
R
V
L
E
V
L
N
E
K
P
A
I
------
E
E
A
D
N
A
----
L
--
A
L
P
-
N
V
E
-
G
S
V
S
F
E
N
V
E
F
R
Y
-
F
E
N
T
D
P
V
L
S
G
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
---
R
---
G
R
V
E
V
D
E
L
D
V
R
T
V
K
L
K
D
L
R
G
H
I
S
A
V
P
Q
E
T
V
L
F
S
G
T
I
K
E
N
L
K
W
G
-
R
E
-
D
---
A
-
T
D
D
E
I
V
--
E
A
A
K
I
A
Q
I
H
D
F
I
I
S
L
P
E
G
Y
D
S
R
V
E
R
G
G
R
N
F
S
G
G
Q
K
Q
R
L
S
I
A
R
A
L
V
K
K
P
K
V
L
I
L
D
D
C
T
S
S
V
D
P
I
T
E
K
R
I
-
L
D
G
L
K
R
Y
T
--
K
G
C
--
T
T
F
I
I
T
Q
K
I
P
T
A
L
L
A
D
K
I
L
V
L
H
E
G
K
V
A
G
F
G
T
H
K
E
L
L
E
--
H
--
C
K
P
Y
R
E
I
Y
E
S
Q
F
---------
4
PsiBlast_PDB
91.23
36%
-118
- C1 -
4Q4H
-
?
A:
[17-579]
---------
Y
L
K
--
P
Y
W
I
F
A
V
L
A
P
L
F
M
V
V
E
V
I
C
D
L
S
Q
-------------
P
T
L
L
A
R
I
V
D
E
G
I
A
R
G
D
--
F
---
S
L
V
L
K
T
G
I
L
---
M
L
I
--
V
A
L
I
G
A
V
G
G
I
G
C
-
T
V
F
A
S
Y
A
S
Q
N
F
G
A
D
L
R
R
D
L
F
R
K
V
L
S
F
S
I
S
N
V
N
R
F
H
T
S
S
L
I
T
R
L
T
N
D
V
--------
T
Q
L
Q
N
L
V
M
M
L
L
R
I
V
V
R
A
P
L
L
F
V
G
G
I
V
M
A
V
S
I
N
V
K
L
S
S
V
L
I
F
L
I
P
P
I
V
L
L
F
V
W
L
T
K
K
G
N
P
L
F
R
K
I
Q
E
S
T
D
E
V
N
R
V
V
R
E
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
E
N
E
N
F
--------
R
K
A
N
E
S
L
-----
R
R
S
I
I
S
A
F
S
L
I
V
F
A
L
P
L
F
I
F
I
V
N
M
G
M
I
A
V
L
-----
W
F
G
------
G
V
L
V
R
N
N
Q
M
E
I
G
S
I
M
-
A
Y
T
N
Y
L
M
Q
I
M
F
S
L
M
--
M
-
I
G
N
I
L
N
F
I
V
R
A
S
A
S
A
K
R
V
L
E
V
L
N
E
K
P
A
I
------
E
E
A
D
N
A
----
L
--
A
L
P
-
N
V
E
-
G
S
V
S
F
E
N
V
E
F
R
Y
-
F
E
N
T
D
P
V
L
S
G
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
---
R
---
G
R
V
E
V
D
E
L
D
V
R
T
V
K
L
K
D
L
R
G
H
I
S
A
V
P
Q
E
T
V
L
F
S
G
T
I
K
E
N
L
K
W
G
-
R
E
-
D
---
A
-
T
D
D
E
I
V
--
E
A
A
K
I
A
Q
I
H
D
F
I
I
S
L
P
E
G
Y
D
S
R
V
E
R
G
G
R
N
F
S
G
G
Q
K
Q
R
L
S
I
A
R
A
L
V
K
K
P
K
V
L
I
L
D
D
C
T
S
S
V
D
P
I
T
E
K
R
I
-
L
D
G
L
K
R
Y
T
--
K
G
C
--
T
T
F
I
I
T
Q
K
I
P
T
A
L
L
A
D
K
I
L
V
L
H
E
G
K
V
A
G
F
G
T
H
K
E
L
L
E
--
H
--
C
K
P
Y
R
E
I
Y
E
S
Q
F
---------
1
PsiBlast_PDB
89.25
36%
-116
- C1 -
4Q4J
-
?
A:
[17-579]
---------
Y
L
K
--
P
Y
W
I
F
A
V
L
A
P
L
F
M
V
V
E
V
I
S
D
L
S
Q
-------------
P
T
L
L
A
R
I
V
D
E
G
I
A
R
G
D
--
F
---
S
L
V
L
K
T
G
I
L
---
M
L
I
--
V
A
L
I
G
A
V
G
G
I
G
S
-
T
V
F
A
S
Y
A
S
Q
N
F
G
A
D
L
R
R
D
L
F
R
K
V
L
S
F
S
I
S
N
V
N
R
F
H
T
S
S
L
I
T
R
L
T
N
D
V
--------
T
Q
L
Q
N
L
V
M
M
L
L
R
I
V
V
R
A
P
L
L
F
V
G
G
I
V
M
A
V
S
I
N
V
K
L
S
S
V
L
I
F
L
I
P
P
I
V
L
L
F
V
W
L
T
K
K
G
N
P
L
F
R
K
I
Q
E
S
T
D
E
V
N
R
V
V
R
E
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
E
N
E
N
F
--------
R
K
A
N
E
S
L
-----
R
R
S
I
I
S
A
F
S
L
I
V
F
A
L
P
L
F
I
F
I
V
N
M
G
M
I
A
V
L
-----
W
F
G
------
G
V
L
V
R
N
N
Q
M
E
I
G
S
I
M
-
A
Y
T
N
Y
L
M
Q
I
M
F
S
L
M
--
M
-
I
G
N
I
L
N
F
I
V
R
A
S
A
S
A
K
R
V
L
E
V
L
N
E
K
P
A
I
------
E
E
A
D
N
A
----
L
--
A
L
P
-
N
V
E
-
G
S
V
S
F
E
N
V
E
F
R
Y
-
F
E
N
T
D
P
V
L
S
G
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
---
R
---
G
R
V
E
V
D
E
L
D
V
R
T
V
K
L
K
D
L
R
G
H
I
S
A
V
P
Q
E
T
V
L
F
S
G
T
I
K
E
N
L
K
W
G
-
R
E
-
D
---
A
-
T
D
D
E
I
V
--
E
A
A
K
I
A
Q
I
H
D
F
I
I
S
L
P
E
G
Y
D
S
R
V
E
R
G
G
R
N
F
S
G
G
Q
K
Q
R
L
S
I
A
R
A
L
V
K
K
P
K
V
L
I
L
D
D
S
T
C
S
V
D
P
I
T
E
K
R
I
-
L
D
G
L
K
R
Y
T
--
K
G
S
--
T
T
F
I
I
T
Q
K
I
P
T
A
L
L
A
D
K
I
L
V
L
H
E
G
K
V
A
G
F
G
T
H
K
E
L
L
E
--
H
--
S
K
P
Y
R
E
I
Y
E
S
Q
F
---------
24
PsiBlast_CBE
78.80
31%
-108
- C1 -
2HYD
3
Y1866_STAAM
B:
[16-576]
--------------------------
I
F
A
T
I
I
--
V
G
I
IKFGIPMLIPLLI
K
Y
A
I
D
G
V
I
N
N
H
A
L
T
T
D
--
E
---
K
V
H
H
L
T
I
A
I
GIA
L
F
I
--
F
V
I
V
R
P
P
I
E
F
I
R
-
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
EQTKD---
F
I
L
T
G
L
--
M
N
I
W
L
D
C
I
T
-
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
-
K
L
T
R
E
R
S
Q
A
-
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
--------
D
K
K
N
T
N
F
LTRAL
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
-
A
-----
Y
L
A
------
I
S
----
G
S
I
T
V
G
T
L
A
-
A
F
V
G
Y
-
L
E
L
L
F
G
P
L
RR
L
-
V
A
S
-
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
D
Y
D
I
------
K
-
N
G
V
G
----
A
--
Q
P
I
-
E
I
K
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
-
N
D
N
E
A
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
---
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
-
R
P
-
T
---
A
-
T
D
E
E
V
V
--
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
-
Q
E
A
L
D
V
L
S
--
K
D
R
--
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
--
K
--
Q
G
A
Y
E
H
L
Y
S
I
Q
N
L
--------
23
PsiBlast_CBE
78.51
31%
-108
- C1 -
2ONJ
4
Y1866_STAAM
B:
[16-576]
--------------------------
I
F
A
T
I
I
--
V
G
I
IKFGIPMLIPLLI
K
Y
A
I
D
G
V
I
N
N
H
A
L
T
T
D
--
E
---
K
V
H
H
L
T
I
A
I
GIA
L
F
I
--
F
V
I
V
R
P
P
I
E
F
I
R
-
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
EQTKD---
F
I
L
T
G
L
--
M
N
I
W
L
D
C
I
T
-
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
-
K
L
T
R
E
R
S
Q
A
-
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
--------
D
K
K
N
T
N
F
LTRAL
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
-
A
-----
Y
L
A
------
I
S
----
G
S
I
T
V
G
T
L
A
-
A
F
V
G
Y
-
L
E
L
L
F
G
P
L
RR
L
-
V
A
S
-
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
D
Y
D
I
------
K
-
N
G
V
G
----
A
--
Q
P
I
-
E
I
K
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
-
N
D
N
E
A
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
---
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
-
R
P
-
T
---
A
-
T
D
E
E
V
V
--
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
-
Q
E
A
L
D
V
L
S
--
K
D
R
--
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
--
K
--
Q
G
A
Y
E
H
L
Y
S
I
Q
N
L
--------
5
PsiBlast_PDB
78.28
31%
-108
- C1 -
2HYD
3
Y1866_STAAM
A:
[16-576]
--------------------------
I
F
A
T
I
I
--
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
G
V
I
N
N
H
A
L
T
T
D
--
E
---
K
V
H
H
L
T
I
A
I
G
I
A
L
F
I
--
F
V
I
V
R
P
P
I
E
F
I
R
-
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D---
F
I
L
T
G
L
--
M
N
I
W
L
D
C
I
T
-
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
-
K
L
T
R
E
R
S
Q
A
-
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
--------
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
-
A
-----
Y
L
A
------
I
S
----
G
S
I
T
V
G
T
L
A
-
A
F
V
G
Y
-
L
E
L
L
F
G
P
L
R
R
L
-
V
A
S
-
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
D
Y
D
I
------
K
-
N
G
V
G
----
A
--
Q
P
I
-
E
I
K
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
-
N
D
N
E
A
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
---
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
-
R
P
-
T
---
A
-
T
D
E
E
V
V
--
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
-
Q
E
A
L
D
V
L
S
--
K
D
R
--
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
--
K
--
Q
G
A
Y
E
H
L
Y
S
I
Q
N
L
--------
6
PsiBlast_PDB
77.33
31%
-108
- C1 -
2ONJ
4
Y1866_STAAM
A:
[16-576]
--------------------------
I
F
A
T
I
I
--
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
G
V
I
N
N
H
A
L
T
T
D
--
E
---
K
V
H
H
L
T
I
A
I
G
I
A
L
F
I
--
F
V
I
V
R
P
P
I
E
F
I
R
-
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D---
F
I
L
T
G
L
--
M
N
I
W
L
D
C
I
T
-
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
-
K
L
T
R
E
R
S
Q
A
-
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
--------
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
-
A
-----
Y
L
A
------
I
S
----
G
S
I
T
V
G
T
L
A
-
A
F
V
G
Y
-
L
E
L
L
F
G
P
L
R
R
L
-
V
A
S
-
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
D
Y
D
I
------
K
-
N
G
V
G
----
A
--
Q
P
I
-
E
I
K
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
-
N
D
N
E
A
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
---
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
-
R
P
-
T
---
A
-
T
D
E
E
V
V
--
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
-
Q
E
A
L
D
V
L
S
--
K
D
R
--
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
--
K
--
Q
G
A
Y
E
H
L
Y
S
I
Q
N
L
--------
89
HHSearch
76.01
24%
-107
- C1 -
3WMG
3
?
A:
[40-598]
----------------------------
G
A
T
L
--
P
A
F
-------------
A
I
V
F
G
R
M
F
Q
V
F
T
K
S
K
S
Q
I
E
---
G
E
T
W
K
Y
S
V
G
---
F
V
G
--
I
G
V
F
E
F
I
V
A
G
S
R
-
T
A
L
F
G
I
A
S
E
R
L
A
R
D
L
R
V
A
A
F
S
N
L
V
E
Q
D
V
T
Y
F
D
R
R
K
A
G
E
L
G
G
K
L
N
N
D
V
--------
Q
V
I
Q
Y
S
F
S
K
L
G
-
A
V
L
F
N
L
A
Q
C
V
V
G
I
I
V
A
F
I
F
A
P
A
L
T
G
V
L
I
A
L
S
P
L
V
V
L
A
V
V
V
Q
M
I
E
M
S
G
N
T
K
R
S
S
E
A
Y
A
S
A
G
S
V
A
A
E
V
F
S
N
I
R
T
T
K
A
F
E
A
E
R
Y
E
T
Q
R
Y
--------
G
S
K
L
D
P
L
-----
Y
R
L
G
R
R
R
Y
I
S
D
G
L
F
F
G
L
S
M
L
V
I
F
C
V
Y
A
L
A
L
-----
W
W
G
------
G
Q
L
I
A
R
G
S
L
N
L
G
N
L
L
-
T
A
F
F
S
A
I
L
G
F
M
G
V
G
--
Q
-
A
A
Q
V
W
P
D
V
T
R
G
L
G
A
G
G
E
L
F
A
M
I
D
R
V
P
Q
Y
------
R
R
P
D
P
G
A
E
V
V
T
--
Q
P
L
-
V
L
K
-
Q
G
I
V
F
E
N
V
H
F
R
Y
P
T
R
M
N
V
E
V
L
R
G
I
S
L
T
I
P
N
G
K
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
L
L
M
R
F
Y
D
I
E
PQG
G
---
G
L
L
L
F
D
G
T
P
A
W
N
Y
D
F
H
A
L
R
S
Q
I
G
L
V
S
Q
E
P
V
L
F
S
G
T
I
R
D
N
I
L
Y
G
-
K
R
-
D
---
A
-
T
D
E
E
V
I
--
Q
A
L
R
E
A
N
A
Y
S
F
V
M
A
L
P
D
G
L
D
T
E
V
G
E
R
G
L
A
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
I
L
K
H
P
T
L
L
C
L
D
E
S
T
S
A
L
D
A
E
S
E
A
L
V
-
Q
E
A
L
D
R
M
M
A
S
D
G
V
--
T
S
V
V
I
A
H
R
L
S
T
V
A
R
A
D
L
I
L
V
M
Q
D
G
V
V
V
E
Q
G
N
H
S
E
L
M
A
--
L
GP
S
G
F
Y
Y
Q
L
V
E
K
Q
L
A
S
-------
107
Fugue
75.76
24%
-104
- C1 -
3B60
2
MSBA_SALTY
A:
[10-581]
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
--
T
F
M
-------------
L
S
L
L
K
P
L
L
D
D
G
F
G
K
T
D
--
R
---
S
V
L
L
W
M
P
L
V
---
V
I
G
--
L
M
I
L
R
G
I
T
S
Y
I
S
-
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
--------
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
--------
D
K
V
S
N
K
M
-----
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
-----
Y
A
A
------
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
-
V
V
F
S
S
M
I
A
L
M
R
P
L
K
--
S
-
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
E
K
------
D
E
G
K
R
V
----
I
--
D
---
R
A
T
-
G
D
L
E
F
R
N
V
T
F
T
Y
P
G
R
-
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
---
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
-
R
T
-
E
---
E
Y
S
R
E
Q
I
E
--
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
-
Q
A
A
L
D
E
L
Q
--
K
N
R
--
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
--
Q
--
H
G
V
Y
A
Q
L
H
K
M
Q
F
G
--------
22
PsiBlast_CBE
74.87
33%
-116
- C1 -
3QF4
1
Y288_THEMA
B:
[104-590]
------------------------------------------------------------------------------------------------------------
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
--
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
----
S
L
V
T
L
S
I
V
--
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
--------
D
R
V
N
E
S
L
-----
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
-
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
A
------
L
----
K
D
I
I
T
V
G
T
I
A
-
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
--
E
-
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
E
K
------
D
-
D
P
D
A
----
V
--
E
L
R
-
E
V
R
-
G
E
I
E
F
K
N
V
W
F
S
Y
--
D
K
K
K
P
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
---
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
-
N
P
-
G
---
A
-
T
D
E
E
I
K
--
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
-
Q
A
A
M
W
K
L
M
--
E
G
K
--
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
--
K
--
R
G
F
Y
Y
E
L
F
T
S
Q
Y
G
L
V
V
E
K
---
21
PsiBlast_CBE
74.71
33%
-116
- C1 -
4Q4A
1
Y288_THEMA
B:
[104-590]
------------------------------------------------------------------------------------------------------------
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
--
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
----
S
L
V
T
L
S
I
V
--
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
--------
D
R
V
N
E
S
L
-----
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
-
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
A
------
L
----
K
D
I
I
T
V
G
T
I
A
-
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
--
E
-
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
E
E
K
------
D
-
D
P
D
A
----
V
--
E
L
R
-
E
V
R
-
G
E
I
E
F
K
N
V
W
F
S
Y
--
D
K
K
K
P
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
---
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
-
N
P
-
G
---
A
-
T
D
E
E
I
K
--
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
-
Q
A
A
M
W
K
L
M
--
E
G
K
--
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
--
K
--
R
G
F
Y
Y
E
L
F
T
S
Q
Y
G
L
-------
19
PsiBlast_PDB
74.18
28%
-105
- C1 -
3WMG
3
?
A:
[80-598]
------------------------------------------------------------------------------------
V
F
E
--
F
I
V
A
G
--
S
R
T
A
L
F
G
I
A
S
E
R
L
A
----
R
D
L
R
V
A
A
F
S
N
L
V
E
Q
D
V
T
Y
F
D
R
R
K
A
G
E
L
G
G
K
L
N
N
D
V
--------
Q
V
I
-
Q
Y
S
F
S
K
L
G
A
V
L
F
N
L
A
Q
C
V
V
G
I
I
V
A
F
I
F
A
P
A
L
T
G
V
L
I
A
L
S
P
L
V
V
L
A
V
V
V
Q
M
I
E
M
S
G
N
T
K
R
S
S
E
A
Y
A
S
A
G
S
V
A
A
E
V
F
S
N
I
R
T
T
K
A
F
E
A
E
R
Y
E
T
Q
R
Y
G
S
K
L
D
P
L
Y
R
L
G
R
R
R
Y
-----
I
--
S
D
G
L
F
--
F
G
L
S
----
M
L
V
I
F
C
V
Y
A
L
A
L
-----
W
W
G
------
G
Q
L
I
A
R
G
S
L
N
L
G
N
L
L
T
A
F
----
F
S
A
I
L
G
F
M
--
G
-
V
G
Q
A
A
Q
V
W
P
D
V
T
R
G
L
G
A
G
G
E
L
F
A
M
I
D
R
V
PQYRRP
D
P
G
A
E
V
----
V
--
T
Q
P
L
V
L
K
-
Q
G
I
V
F
E
N
V
H
F
R
Y
P
T
R
M
N
V
E
V
L
R
G
I
S
L
T
I
P
N
G
K
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
L
L
M
R
F
Y
D
I
E
---
P
QGG
G
L
L
L
F
D
G
T
P
A
W
N
Y
D
F
H
A
L
R
S
Q
I
G
L
V
S
Q
E
P
V
L
F
S
G
T
I
R
D
N
I
L
Y
G
-
K
R
-
D
---
A
-
T
D
E
E
V
I
--
Q
A
L
R
E
A
N
A
Y
S
F
V
M
A
L
P
D
G
L
D
T
E
V
G
E
R
G
L
A
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
I
L
K
H
P
T
L
L
C
L
D
E
S
T
S
A
L
D
A
E
S
E
A
L
V
-
Q
E
A
L
D
R
M
M
--
A
S
D
G
V
T
S
V
V
I
A
H
R
L
S
T
V
A
R
A
D
L
I
L
V
M
Q
D
G
V
V
V
E
Q
G
N
H
S
E
L
M
A
L
G
P
--
S
G
F
Y
Y
Q
L
V
E
K
Q
L
A
S
-------
18
PsiBlast_PDB
73.96
28%
-106
- C1 -
3WMF
-
?
A:
[80-597]
------------------------------------------------------------------------------------
V
F
E
--
F
I
V
A
G
--
S
R
T
A
L
F
G
I
A
S
E
R
L
A
----
R
D
L
R
V
A
A
F
S
N
L
V
E
Q
D
V
T
Y
F
D
R
R
K
A
G
E
L
G
G
K
L
N
N
D
V
--------
Q
V
I
-
Q
Y
S
F
S
K
L
G
A
V
L
F
N
L
A
Q
C
V
V
G
I
I
V
A
F
I
F
A
P
A
L
T
G
V
L
I
A
L
S
P
L
V
V
L
A
V
V
V
Q
M
I
E
M
S
G
N
T
K
R
S
S
E
A
Y
A
S
A
G
S
V
A
A
E
V
F
S
N
I
R
T
T
K
A
F
E
A
E
R
Y
E
T
Q
R
Y
G
S
K
L
D
P
L
Y
R
L
G
R
R
R
Y
-----
I
--
S
D
G
L
F
--
F
G
L
S
----
M
L
V
I
F
C
V
Y
A
L
A
L
-----
W
W
G
------
G
Q
L
I
A
R
G
S
L
N
L
G
N
L
L
T
A
F
----
F
S
A
I
L
G
F
M
--
G
-
V
G
Q
A
A
Q
V
W
P
D
V
T
R
G
L
G
A
G
G
E
L
F
A
M
I
D
R
V
PQYRRP
D
P
G
A
E
V
----
V
--
T
Q
P
L
V
L
K
-
Q
G
I
V
F
E
N
V
H
F
R
Y
P
T
R
M
N
V
E
V
L
R
G
I
S
L
T
I
P
N
G
K
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
L
L
M
R
F
Y
D
I
E
---
P
QGG
G
L
L
L
F
D
G
T
P
A
W
N
Y
D
F
H
A
L
R
S
Q
I
G
L
V
S
Q
E
P
V
L
F
S
G
T
I
R
D
N
I
L
Y
G
-
K
R
-
D
---
A
-
T
D
E
E
V
I
--
Q
A
L
R
E
A
N
A
Y
S
F
V
M
A
L
P
D
G
L
D
T
E
V
G
E
R
G
L
A
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
I
L
K
H
P
T
L
L
C
L
D
E
S
T
S
A
L
D
A
E
S
E
A
L
V
-
Q
E
A
L
D
R
M
M
--
A
S
D
G
V
T
S
V
V
I
A
H
R
L
S
T
V
A
R
A
D
L
I
L
V
M
Q
D
G
V
V
V
E
Q
G
N
H
S
E
L
M
A
LG
P
--
S
G
F
Y
Y
Q
L
V
E
K
Q
L
A
--------
88
HHSearch
73.30
25%
-105
- C1 -
3ZDQ
6
ABCBA_HUMAN
A:
[7-572]
---
A
R
K
L
L
G
L
A
Y
P
E
R
R
R
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
--
M
S
A
-------------
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
--
V
DY
S
D
N
L
T
R
L
C
L
G
---
L
S
A
--
V
F
L
C
G
A
A
A
N
A
I
R
-
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
--------
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
--------
A
S
K
V
D
H
V
-----
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
-----
Y
K
G
------
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
-
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
--
G
-
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
P
K
L
------
P
F
N
E
G
V
----
I
--
L
N
E
K
S
F
Q
-
G
A
L
E
F
K
N
V
H
F
A
Y
P
A
R
P
E
V
P
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
---
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
-
A
D
-
D
PSS
V
-
T
A
E
E
I
Q
--
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
-
Q
E
A
L
D
R
L
M
--
D
G
R
--
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
--
K
P----------------------
11
PsiBlast_PDB
72.55
28%
-97
- C1 -
3B60
2
MSBA_SALTY
A:
[44-579]
------------------------------------
M
-------------
L
S
L
L
K
P
L
L
D
D
G
F
G
K
T
D
--
R
---
S
-
V
L
L
W
M
P
L
---
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
--
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
--------
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
--------
D
K
V
S
N
K
M
-----
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
-
I
Q
L
I
A
S
L
A
L
A
F
V
-----
L
Y
A
A
S
FPSV
M
D
S
L
T
A
G
T
I
T
V
-------
V
F
S
S
M
I
A
L
M
R
P
L
--
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
---
S
E
------
Q
E
K
D
E
G
K
R--
V
--
I
D
--
R
A
T
-
G
D
L
E
F
R
N
V
T
F
T
Y
P
G
R
-
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
---
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
-
R
T
-
E
---
E
Y
S
R
E
Q
I
E
--
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
-
Q
A
A
L
D
E
L
Q
--
K
N
R
--
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
--
Q
--
H
G
V
Y
A
Q
L
H
K
M
Q
F
G
--------
86
HHSearch
71.52
25%
-96
- C1 -
3B60
2
MSBA_SALTY
A:
[38-581]
----------------------------
A
A
S
D
--
T
F
M
-------------
L
S
L
L
K
P
L
L
D
D
G
F
G
K
T
D
--
R
---
S
V
L
L
W
M
P
L
V
---
V
I
G
--
L
M
I
L
R
G
I
T
S
Y
I
S
-
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
--------
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
--------
D
K
V
S
N
K
M
-----
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
-----
Y
A
A
------
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
-
V
V
F
S
S
M
I
A
L
M
R
P
L
K
--
S
-
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
E
K
------
D
E
G
K
R
V
--------
I
D
-
R
A
T
-
G
D
L
E
F
R
N
V
T
F
T
Y
P
G
R
E
-
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
---
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
-
R
T
E
E
---
Y
-
S
R
E
Q
I
E
--
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
-
Q
A
A
L
D
E
L
Q
--
K
N
R
--
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
--
Q
--
H
G
V
Y
A
Q
L
H
K
M
Q
F
G
--------
13
PsiBlast_PDB
70.19
29%
-103
- C1 -
4AYX
5
ABCBA_HUMAN
A:
[93-574]
----------------------------------------------------------------------------------------------------------------
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
--------
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
-
R
K
E
-----
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
-------
I
V
L
S
V
L
-----
Y
K
G
------
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
-
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
--
G
-
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
P
K
L
-------
P
F
N
E
G
----
V
I
L
N
E
K
-
S
F
Q
-
G
A
L
E
F
K
N
V
H
F
A
Y
P
A
R
P
E
V
P
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
---
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
-
A
D
-
D
PSS
V
-
T
A
E
E
I
Q
--
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
-
Q
E
A
L
D
R
L
M
--
D
G
R
--
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
--
K
P-
N
G
-------------------
14
PsiBlast_PDB
69.80
29%
-101
- C1 -
3ZDQ
4
ABCBA_HUMAN
A:
[93-572]
----------------------------------------------------------------------------------------------------------------
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
--------
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
-
R
K
E
-----
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
-------
I
V
L
S
V
L
-----
Y
K
G
------
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
-
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
--
G
-
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
P
K
L
-------
P
F
N
E
G
----
V
I
L
N
E
K
-
S
F
Q
-
G
A
L
E
F
K
N
V
H
F
A
Y
P
A
R
P
E
V
P
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
---
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
-
A
D
-
D
PSS
V
-
T
A
E
E
I
Q
--
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
-
Q
E
A
L
D
R
L
M
--
D
G
R
--
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
--
K
P----------------------
12
PsiBlast_PDB
68.98
29%
-100
- C1 -
4AYT
6
ABCBA_HUMAN
A:
[93-567]
----------------------------------------------------------------------------------------------------------------
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
--------
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
-
R
K
E
-----
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
-------
I
V
L
S
V
L
-----
Y
K
G
------
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
-
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
--
G
-
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
P
K
L
-------
P
F
N
E
G
----
V
I
L
N
E
K
-
S
F
Q
-
G
A
L
E
F
K
N
V
H
F
A
Y
P
A
R
P
E
V
P
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
---
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
-
A
D
-
D
PSS
V
-
T
A
E
E
I
Q
--
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
-
Q
E
A
L
D
R
L
M
--
D
G
R
--
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
-----------------------------
94
HHSearch
52.10
34%
-81
- C1 -
2IXE
4
TAP1_RAT
A:
[14-256]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
G
L
V
K
F
Q
D
V
S
F
A
Y
P
N
H
P
N
V
Q
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
---
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
S
F
R
E
N
I
A
Y
G
-
L
T
-
R
---
T
P
T
M
E
E
I
T
--
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
N
A
T
S
A
L
D
A
G
N
Q
L
R
V
-
Q
R
L
L
Y
E
S
P
E
W
A
S
R
--
T
V
L
L
I
T
Q
Q
L
S
L
A
E
R
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
--
R
--
G
G
C
Y
R
S
M
V
E
A
-----------
69
PsiBlast_CBE
52.04
32%
-83
- C1 -
2IXG
2
A:
[4-255]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
G
S
----
L
--
A
P
L
-
N
M
K
-
G
L
V
K
F
Q
D
V
S
F
A
Y
P
N
H
P
N
V
Q
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
---
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
S
F
R
E
N
I
A
Y
G
L
T
R
-
T
---
P
-
T
M
E
E
I
T
--
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
A
V
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
N
A
T
S
A
L
D
A
G
N
Q
L
R
V
-
Q
R
L
L
Y
E
S
P
EW
A
S
R
--
T
V
L
L
I
T
Q
Q
L
S
L
A
E
R
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
--
R
--
G
G
C
Y
R
S
M
V
E
A
L
----------
62
PsiBlast_CBE
51.84
32%
-81
- C1 -
2IXE
4
TAP1_RAT
A:
[6-255]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
----
L
--
A
P
L
-
N
M
K
-
G
L
V
K
F
Q
D
V
S
F
A
Y
P
N
H
P
N
V
Q
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
---
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
S
F
R
E
N
I
A
Y
G
L
T
R
-
T
---
P
-
T
M
E
E
I
T
--
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
N
A
T
S
A
L
D
A
G
N
Q
L
R
V
-
Q
R
L
L
Y
E
S
P
E
W
A
S
R
--
T
V
L
L
I
T
Q
Q
L
S
L
A
E
R
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
--
R
--
G
G
C
Y
R
S
M
V
E
A
-----------
76
PsiBlast_CBE
41.13
34%
-85
- C1 -
2PZF
3
B:
[10-215]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
V
T
-
A
F
W
E
E
G
G
T
P
V
L
K
D
I
N
F
K
I
E
R
G
Q
L
L
A
V
A
G
S
T
G
A
G
K
T
S
L
L
M
M
I
M
G
E
L
E
P
S
---
E
---
G
K
I
K
H
S
G
-------------
R
I
S
F
C
S
Q
F
S
W
I
M
P
G
T
I
K
E
N
I
-----
I
-
G
---
V
-
S
Y
D
E
Y
R
YR
S
V
I
K
A
C
Q
L
E
E
D
I
S
K
F
A
E
K
D
N
I
V
L
G
E
G
G
I
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
L
T
E
K
E
I
F
E
S
C
V
C
K
L
M
--
A
N
K
--
T
R
I
L
V
T
S
K
M
E
H
L
K
K
A
D
K
I
L
I
L
H
E
G
S
S
Y
F
Y
G
T
F
S
E
L
Q
N
--
L
-----------------------