@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1850: (2015-12-11 )
MKYFLDTADVSEIRRLNRLGIVDGVTTNPTIISREGRDFKEVINEICQIVDGPVSAEVTGLTCDEMVTEAREIAKWSPNVVVKIPMTEEGLAAVSQLSKEGIKTNVTLIFTVAQGLSAMKAGATFISPFVGRLEDIGTDAYALIRDLRHIIDFYGFQSEIIAASIRGLAHVEGVAKCGAHIATIPDKTFASLFTHPLTDKGIETFLKDWDSFKKK
Atome Classification :
(33 SA)
.........10........20........30....---..-.---.40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
Y
FLDTA
D
V
S
E
I
R
R
L
N
RLGIVDGVTTN
P
T
I
I
SRE---GR-
D
---
F
K
E
V
I
N
E
I
C
Q
IVDGPVS
A
E
V
TGL
T
C
D
E
M
V
T
E
A
R
E
I
AKWSP
N
V
V
V
K
IPMT
E
E
G
L
A
A
V
S
Q
L
S
KEGIKT
N
V
T
L
I
F
T
V
A
Q
G
L
S
A
M
KA
G
A
T
F
I
S
P
F
V
G
R
L
E
DIG
T
D
A
Y
A
L
I
R
D
L
R
H
I
I
D
F
YGF
Q
S
E
I
I
A
A
S
I
RG
L
A
H
V
E
G
V
A
K
CG
A
H
I
ATIP
D
K
T
F
A
S
L
FTHPL
T
D
K
G
I
E
T
F
L
K
D
W
D
S
FKKK
84
HHSearch
96.58
54%
-128
- C4 -
1VPX
-
TAL_THEMA
A:
[13-226]
M
K
I
F
L
D
T
A
N
L
E
E
I
K
K
G
V
E
W
G
I
V
D
G
V
T
T
N
P
------------------
Q
R
V
K
E
I
C
D
L
V
K
G
P
V
S
A
E
V
V
S
L
D
Y
E
G
M
V
R
E
A
R
E
L
A
Q
I
S
E
Y
V
V
I
K
I
P
M
T
P
D
G
I
K
A
V
K
T
L
S
A
E
G
I
K
T
N
V
T
L
V
F
S
P
A
Q
A
I
L
A
A
K
A
G
A
T
Y
V
S
P
F
V
G
R
M
D
D
L
S
N
D
G
M
R
M
L
G
E
I
V
E
I
Y
N
N
Y
G
F
E
T
E
I
I
A
A
S
I
R
H
P
M
H
V
V
E
A
A
L
M
G
V
D
I
V
T
M
P
F
A
V
L
E
K
L
F
K
H
P
M
T
D
L
G
I
E
R
F
M
E
D
W
K
K
Y
L
E
N
23
PsiBlast_CBE
96.19
54%
-126
- C4 -
1VPX
1
TAL_THEMA
R:
[13-224]
M
K
I
F
L
D
T
A
N
L
E
E
I
K
K
G
V
E
W
G
I
V
D
G
V
T
T
N
P
T
---------
A
-
E
---
F
K
Q
R
V
K
E
I
C
D
L
V
K
G
P
V
S
A
E
V
V
S
L
D
Y
E
G
M
V
R
E
A
R
E
L
A
Q
I
S
E
Y
V
V
I
K
I
P
M
T
P
D
G
I
K
A
V
K
T
L
S
A
E
G
I
K
T
N
V
T
L
V
F
S
P
A
Q
A
I
L
A
A
K
A
G
A
T
Y
V
S
P
F
V
G
R
M
D
D
L
S
N
D
G
M
R
M
L
G
E
I
V
E
I
Y
N
N
Y
G
F
E
T
E
I
I
A
A
S
I
R
H
P
M
H
V
V
E
A
A
L
M
G
V
D
I
V
T
M
P
F
A
V
L
E
K
L
F
K
H
P
M
T
D
L
G
I
E
R
F
M
E
D
W
K
K
Y
L
E
N
1
PsiBlast_PDB
95.95
54%
-129
- C4 -
1VPX
-
TAL_THEMA
A:
[13-224]
M
K
I
F
L
D
T
A
N
L
E
E
I
K
K
G
V
E
W
G
I
V
D
G
V
T
T
N
P
------------------
Q
R
V
K
E
I
C
D
L
V
K
G
P
V
S
A
E
V
V
S
L
D
Y
E
G
M
V
R
E
A
R
E
L
A
Q
I
S
E
Y
V
V
I
K
I
P
M
T
P
D
G
I
K
A
V
K
T
L
S
A
E
G
I
K
T
N
V
T
L
V
F
S
P
A
Q
A
I
L
A
A
K
A
G
A
T
Y
V
S
P
F
V
G
R
M
D
D
L
S
N
D
G
M
R
M
L
G
E
I
V
E
I
Y
N
N
Y
G
F
E
T
E
I
I
A
A
S
I
R
H
P
M
H
V
V
E
A
A
L
M
G
V
D
I
V
T
M
P
F
A
V
L
E
K
L
F
K
H
P
M
T
D
L
G
I
E
R
F
M
E
D
W
K
K
Y
L
E
N
30
PsiBlast_CBE
95.85
54%
-124
- C4 -
1VPX
1
TAL_THEMA
K:
[13-224]
M
K
I
F
L
D
T
A
N
L
E
E
I
K
K
G
V
E
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
---
G
A
-
E
---
F
K
Q
R
V
K
E
I
C
D
L
V
K
G
P
V
S
A
E
V
V
S
L
D
Y
E
G
M
V
R
E
A
R
E
L
A
Q
I
S
E
Y
V
V
I
K
I
P
M
T
P
D
G
I
K
A
V
K
T
L
S
A
E
G
I
K
T
N
V
T
L
V
F
S
P
A
Q
A
I
L
A
A
K
A
G
A
T
Y
V
S
P
F
V
G
R
M
D
D
L
S
N
D
G
M
R
M
L
G
E
I
V
E
I
Y
N
N
Y
G
F
E
T
E
I
I
A
A
S
I
R
H
P
M
H
V
V
E
A
A
L
M
G
V
D
I
V
T
M
P
F
A
V
L
E
K
L
F
K
H
P
M
T
D
L
G
I
E
R
F
M
E
D
W
K
K
Y
L
E
N
26
PsiBlast_CBE
95.17
54%
-123
- C4 -
1VPX
1
TAL_THEMA
O:
[13-220]
M
K
I
F
L
D
T
A
N
L
E
E
I
K
K
G
V
E
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
---
G
A
-
E
---
F
K
Q
R
V
K
E
I
C
D
L
V
K
G
P
V
S
A
E
V
V
S
L
D
Y
E
G
M
V
R
E
A
R
E
L
A
Q
I
S
E
Y
V
V
I
K
I
P
M
T
P
D
G
I
K
A
V
K
T
L
S
A
E
G
I
K
T
N
V
T
L
V
F
S
P
A
Q
A
I
L
A
A
K
A
G
A
T
Y
V
S
P
F
V
G
R
M
D
D
L
S
N
D
G
M
R
M
L
G
E
I
V
E
I
Y
N
N
Y
G
F
E
T
E
I
I
A
A
S
I
R
H
P
M
H
V
V
E
A
A
L
M
G
V
D
I
V
T
M
P
F
A
V
L
E
K
L
F
K
H
P
M
T
D
L
G
I
E
R
F
M
E
D
-------
67
PsiBlast_CBE
95.12
51%
-122
- C4 -
3S1U
2
TAL_THEAC
D:
[1-212]
M
K
I
F
L
D
T
A
N
I
D
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN
G
K
-
K
---
Y
G
D
I
I
R
E
I
L
K
I
V
D
G
P
V
S
V
E
V
V
S
T
K
Y
E
G
M
V
E
E
A
R
K
I
H
G
L
G
D
N
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
S
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
Y
V
S
P
F
V
G
R
L
D
D
I
G
E
D
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
I
I
K
T
Q
I
L
V
A
S
I
R
N
P
I
H
V
L
R
S
A
V
I
G
A
D
V
V
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
K
V
S
P
D
55
PsiBlast_CBE
94.53
52%
-126
- C4 -
3R8R
1
TAL_BACSU
D:
[1-211]
M
L
F
F
V
D
T
A
N
I
D
E
I
R
E
A
N
E
L
G
I
L
A
G
V
T
T
N
P
S
L
V
A
--------
S
---
F
H
D
R
L
R
E
I
T
D
V
V
K
G
S
V
S
A
E
V
I
S
L
K
A
E
E
M
I
E
E
G
K
E
L
A
K
I
A
P
N
I
T
V
K
I
P
M
T
S
D
G
L
K
A
V
R
A
L
T
D
L
G
I
K
T
N
V
T
L
I
F
N
A
N
Q
A
L
L
A
A
R
A
G
A
T
Y
V
S
P
F
L
G
R
L
D
D
I
G
H
N
G
L
D
L
I
S
E
V
K
Q
I
F
D
I
H
G
L
D
T
Q
I
I
A
A
S
I
R
H
P
Q
H
V
T
E
A
A
L
R
G
A
H
I
G
T
M
P
L
K
V
I
H
A
L
T
K
H
P
L
T
D
K
G
I
E
Q
F
L
A
D
W
N
K
----
4
PsiBlast_PDB
94.34
51%
-122
- C4 -
3S1U
1
TAL_THEAC
A:
[1-212]
M
K
I
F
L
D
T
A
N
I
D
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN
G
K
-
K
---
Y
G
D
I
I
R
E
I
L
K
I
V
D
G
P
V
S
V
E
V
V
S
T
K
Y
E
G
M
V
E
E
A
R
K
I
H
G
L
G
D
N
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
S
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
Y
V
S
P
F
V
G
R
L
D
D
I
G
E
D
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
I
I
K
T
Q
I
L
V
A
S
I
R
N
P
I
H
V
L
R
S
A
V
I
G
A
D
V
V
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
K
V
S
P
D
21
PsiBlast_CBE
94.11
54%
-129
- C4 -
1VPX
15
TAL_THEMA
T:
[13-224]
M
K
I
F
L
D
T
A
N
L
E
E
I
K
K
G
V
E
W
G
I
V
D
G
V
T
T
N
P
T
-------------------
V
K
E
I
C
D
L
V
K
G
P
V
S
A
E
V
V
S
L
D
Y
E
G
M
V
R
E
A
R
E
L
A
Q
I
S
E
Y
V
V
I
K
I
P
M
T
P
D
G
I
K
A
V
K
T
L
S
A
E
G
I
K
T
N
V
T
L
V
F
S
P
A
Q
A
I
L
A
A
K
A
G
A
T
Y
V
S
P
F
V
G
R
M
D
D
L
S
N
D
G
M
R
M
L
G
E
I
V
E
I
Y
N
N
Y
G
F
E
T
E
I
I
A
A
S
I
R
H
P
M
H
V
V
E
A
A
L
M
G
V
D
I
V
T
M
P
F
A
V
L
E
K
L
F
K
H
P
M
T
D
L
G
I
E
R
F
M
E
D
W
K
K
Y
L
E
N
39
PsiBlast_CBE
94.04
54%
-120
- C4 -
1VPX
1
TAL_THEMA
B:
[13-219]
M
K
I
F
L
D
T
A
N
L
E
E
I
K
K
G
V
E
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
---
G
A
-
E
---
F
K
Q
R
V
K
E
I
C
D
L
V
K
G
P
V
S
A
E
V
V
S
L
D
Y
E
G
M
V
R
E
A
R
E
L
A
Q
I
S
E
Y
V
V
I
K
I
P
M
T
P
D
G
I
K
A
V
K
T
L
S
A
E
G
I
K
T
N
V
T
L
V
F
S
P
A
Q
A
I
L
A
A
K
A
G
A
T
Y
V
S
P
F
V
G
R
M
D
D
L
S
N
D
G
M
R
M
L
G
E
I
V
E
I
Y
N
N
Y
G
F
E
T
E
I
I
A
A
S
I
R
H
P
M
H
V
V
E
A
A
L
M
G
V
D
I
V
T
M
P
F
A
V
L
E
K
L
F
K
H
P
M
T
D
L
G
I
E
R
F
M
E
--------
83
HHSearch
93.89
53%
-121
- C4 -
3R8R
2
TAL_BACSU
A:
[1-212]
M
L
F
F
V
D
T
A
N
I
D
E
I
R
E
A
N
E
L
G
I
L
A
G
V
T
T
N
P
S
L
V
A
K
E
---
A
N
V
S
---
F
H
D
R
L
R
E
I
T
D
V
V
K
G
S
V
S
A
E
V
I
S
L
K
A
E
E
M
I
E
E
G
K
E
L
A
K
I
A
P
N
I
T
V
K
I
P
M
T
S
D
G
L
K
A
V
R
A
L
T
D
L
G
I
K
T
N
V
T
L
I
F
N
A
N
Q
A
L
L
A
A
R
A
G
A
T
Y
V
S
P
F
L
G
R
L
D
D
I
G
H
N
G
L
D
L
I
S
E
V
K
Q
I
F
D
I
H
G
L
D
T
Q
I
I
A
A
S
I
R
H
P
Q
H
V
T
E
A
A
L
R
G
A
H
I
G
T
M
P
L
K
V
I
H
A
L
T
K
H
P
L
T
D
K
G
I
E
Q
F
L
A
D
W
N
K
----
66
PsiBlast_CBE
93.85
51%
-119
- C4 -
3S1U
1
TAL_THEAC
E:
[1-212]
M
K
I
F
L
D
T
A
N
I
D
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN
G
K
-
K
---
Y
G
D
I
I
R
E
I
L
K
I
V
D
G
P
V
S
V
E
V
V
S
T
K
Y
E
G
M
V
E
E
A
R
K
I
H
G
L
G
D
N
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
S
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
Y
V
S
P
F
V
G
R
L
D
D
I
G
E
D
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
I
I
K
T
Q
I
L
V
A
S
I
R
N
P
I
H
V
L
R
S
A
V
I
G
A
D
V
V
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
K
V
S
P
D
2
PsiBlast_PDB
93.46
52%
-121
- C4 -
3R8R
2
TAL_BACSU
A:
[1-211]
M
L
F
F
V
D
T
A
N
I
D
E
I
R
E
A
N
E
L
G
I
L
A
G
V
T
T
N
P
S
L
V
A
K
E
---
A
N
V
S
---
F
H
D
R
L
R
E
I
T
D
V
V
K
G
S
V
S
A
E
V
I
S
L
K
A
E
E
M
I
E
E
G
K
E
L
A
K
I
A
P
N
I
T
V
K
I
P
M
T
S
D
G
L
K
A
V
R
A
L
T
D
L
G
I
K
T
N
V
T
L
I
F
N
A
N
Q
A
L
L
A
A
R
A
G
A
T
Y
V
S
P
F
L
G
R
L
D
D
I
G
H
N
G
L
D
L
I
S
E
V
K
Q
I
F
D
I
H
G
L
D
T
Q
I
I
A
A
S
I
R
H
P
Q
H
V
T
E
A
A
L
R
G
A
H
I
G
T
M
P
L
K
V
I
H
A
L
T
K
H
P
L
T
D
K
G
I
E
Q
F
L
A
D
W
N
K
----
57
PsiBlast_CBE
93.19
52%
-122
- C4 -
3R8R
2
TAL_BACSU
B:
[1-211]
M
L
F
F
V
D
T
A
N
I
D
E
I
R
E
A
N
E
L
G
I
L
A
G
V
T
T
N
P
S
L
V
A
K
E
---
A
N
V
S
---
F
H
D
R
L
R
E
I
T
D
V
V
K
G
S
V
S
A
E
V
I
S
L
K
A
E
E
M
I
E
E
G
K
E
L
A
K
I
A
P
N
I
T
V
K
I
P
M
T
S
D
G
L
K
A
V
R
A
L
T
D
L
G
I
K
T
N
V
T
L
I
F
N
A
N
Q
A
L
L
A
A
R
A
G
A
T
Y
V
S
P
F
L
G
R
L
D
D
I
G
H
N
G
L
D
L
I
S
E
V
K
Q
I
F
D
I
H
G
L
D
T
Q
I
I
A
A
S
I
R
H
P
Q
H
V
T
E
A
A
L
R
G
A
H
I
G
T
M
P
L
K
V
I
H
A
L
T
K
H
P
L
T
D
K
G
I
E
Q
F
L
A
D
W
N
K
----
62
PsiBlast_CBE
93.02
51%
-118
- C4 -
3S1V
1
TAL_THEAC
E:
[1-212]
M
K
I
F
L
D
T
A
N
I
D
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN
G
K
-
K
---
Y
G
D
I
I
R
E
I
L
K
I
V
D
G
P
V
S
V
E
V
V
S
T
K
Y
E
G
M
V
E
E
A
R
K
I
H
G
L
G
D
N
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
S
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
Y
V
S
P
F
V
G
R
L
D
D
I
G
E
D
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
I
I
K
T
Q
I
L
V
A
S
I
R
N
P
I
H
V
L
R
S
A
V
I
G
A
D
V
V
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
K
V
S
P
D
63
PsiBlast_CBE
93.00
51%
-119
- C4 -
3S1V
2
TAL_THEAC
D:
[1-212]
M
K
I
F
L
D
T
A
N
I
D
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN
G
K
-
K
---
Y
G
D
I
I
R
E
I
L
K
I
V
D
G
P
V
S
V
E
V
V
S
T
K
Y
E
G
M
V
E
E
A
R
K
I
H
G
L
G
D
N
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
S
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
Y
V
S
P
F
V
G
R
L
D
D
I
G
E
D
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
I
I
K
T
Q
I
L
V
A
S
I
R
N
P
I
H
V
L
R
S
A
V
I
G
A
D
V
V
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
K
V
S
P
D
60
PsiBlast_CBE
92.79
51%
-119
- C4 -
3S1X
1
TAL_THEAC
C:
[1-212]
M
K
I
F
L
D
T
A
N
I
D
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN
G
K
-
K
---
Y
G
D
I
I
R
E
I
L
K
I
V
D
G
P
V
S
V
E
V
V
S
T
K
Y
E
G
M
V
E
E
A
R
K
I
H
G
L
G
D
N
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
S
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
Y
V
S
P
F
V
G
R
L
D
D
I
G
E
D
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
I
I
K
T
Q
I
L
V
A
S
I
R
N
P
I
H
V
L
R
S
A
V
I
G
A
D
V
V
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
K
V
S
P
D
65
PsiBlast_CBE
92.69
51%
-118
- C4 -
3S1V
2
TAL_THEAC
B:
[1-212]
M
K
I
F
L
D
T
A
N
I
D
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN
G
K
-
K
---
Y
G
D
I
I
R
E
I
L
K
I
V
D
G
P
V
S
V
E
V
V
S
T
K
Y
E
G
M
V
E
E
A
R
K
I
H
G
L
G
D
N
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
S
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
Y
V
S
P
F
V
G
R
L
D
D
I
G
E
D
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
I
I
K
T
Q
I
L
V
A
S
I
R
N
P
I
H
V
L
R
S
A
V
I
G
A
D
V
V
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
K
V
S
P
D
64
PsiBlast_CBE
92.62
51%
-120
- C4 -
3S1V
1
TAL_THEAC
C:
[1-212]
M
K
I
F
L
D
T
A
N
I
D
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN
G
K
-
K
---
Y
G
D
I
I
R
E
I
L
K
I
V
D
G
P
V
S
V
E
V
V
S
T
K
Y
E
G
M
V
E
E
A
R
K
I
H
G
L
G
D
N
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
S
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
Y
V
S
P
F
V
G
R
L
D
D
I
G
E
D
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
I
I
K
T
Q
I
L
V
A
S
I
R
N
P
I
H
V
L
R
S
A
V
I
G
A
D
V
V
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
K
V
S
P
D
68
PsiBlast_CBE
92.59
51%
-118
- C4 -
3S1U
2
TAL_THEAC
C:
[1-212]
M
K
I
F
L
D
T
A
N
I
D
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN
G
K
-
K
---
Y
G
D
I
I
R
E
I
L
K
I
V
D
G
P
V
S
V
E
V
V
S
T
K
Y
E
G
M
V
E
E
A
R
K
I
H
G
L
G
D
N
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
S
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
Y
V
S
P
F
V
G
R
L
D
D
I
G
E
D
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
I
I
K
T
Q
I
L
V
A
S
I
R
N
P
I
H
V
L
R
S
A
V
I
G
A
D
V
V
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
K
V
S
P
D
3
PsiBlast_PDB
92.54
51%
-117
- C4 -
3S0C
1
TAL_THEAC
A:
[1-212]
M
K
I
F
L
D
T
A
N
I
D
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN
G
K
-
K
---
Y
G
D
I
I
R
E
I
L
K
I
V
D
G
P
V
S
V
E
V
V
S
T
K
Y
E
G
M
V
E
E
A
R
K
I
H
G
L
G
D
N
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
S
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
Y
V
S
P
F
V
G
R
L
D
D
I
G
E
D
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
I
I
K
T
Q
I
L
V
A
S
I
R
N
P
I
H
V
L
R
S
A
V
I
G
A
D
V
V
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
K
V
S
P
D
73
PsiBlast_CBE
92.45
50%
-117
- C4 -
3S1W
2
TAL_THEAC
B:
[1-212]
M
K
I
F
L
D
T
A
N
I
D
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN
G
K
-
K
---
Y
G
D
I
I
R
E
I
L
K
I
V
D
G
P
V
S
V
E
V
V
S
T
K
Y
E
G
M
V
E
E
A
R
K
I
H
G
L
G
D
N
A
V
V
A
I
P
M
T
E
D
G
L
R
A
I
K
T
L
S
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
Y
V
S
P
F
V
G
R
L
D
D
I
G
E
D
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
I
I
K
T
Q
I
L
V
A
S
I
R
N
P
I
H
V
L
R
S
A
V
I
G
A
D
V
V
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
K
V
S
P
D
69
PsiBlast_CBE
92.29
51%
-117
- C4 -
3S1U
1
TAL_THEAC
B:
[1-212]
M
K
I
F
L
D
T
A
N
I
D
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN
G
K
-
K
---
Y
G
D
I
I
R
E
I
L
K
I
V
D
G
P
V
S
V
E
V
V
S
T
K
Y
E
G
M
V
E
E
A
R
K
I
H
G
L
G
D
N
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
S
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
Y
V
S
P
F
V
G
R
L
D
D
I
G
E
D
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
I
I
K
T
Q
I
L
V
A
S
I
R
N
P
I
H
V
L
R
S
A
V
I
G
A
D
V
V
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
K
V
S
P
-
70
PsiBlast_CBE
91.83
50%
-117
- C4 -
3S1W
2
TAL_THEAC
E:
[1-212]
M
K
I
F
L
D
T
A
N
I
D
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN
G
K
-
K
---
Y
G
D
I
I
R
E
I
L
K
I
V
D
G
P
V
S
V
E
V
V
S
T
K
Y
E
G
M
V
E
E
A
R
K
I
H
G
L
G
D
N
A
V
V
A
I
P
M
T
E
D
G
L
R
A
I
K
T
L
S
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
Y
V
S
P
F
V
G
R
L
D
D
I
G
E
D
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
I
I
K
T
Q
I
L
V
A
S
I
R
N
P
I
H
V
L
R
S
A
V
I
G
A
D
V
V
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
K
V
S
P
D
58
PsiBlast_CBE
91.81
51%
-117
- C4 -
3S1X
2
TAL_THEAC
E:
[1-212]
M
K
I
F
L
D
T
A
N
I
D
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN
G
K
-
K
---
Y
G
D
I
I
R
E
I
L
K
I
V
D
G
P
V
S
V
E
V
V
S
T
K
Y
E
G
M
V
E
E
A
R
K
I
H
G
L
G
D
N
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
S
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
Y
V
S
P
F
V
G
R
L
D
D
I
G
E
D
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
I
I
K
T
Q
I
L
V
A
S
I
R
N
P
I
H
V
L
R
S
A
V
I
G
A
D
V
V
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
K
V
S
P
D
72
PsiBlast_CBE
91.65
50%
-115
- C4 -
3S1W
2
TAL_THEAC
C:
[1-212]
M
K
I
F
L
D
T
A
N
I
D
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN
G
K
-
K
---
Y
G
D
I
I
R
E
I
L
K
I
V
D
G
P
V
S
V
E
V
V
S
T
K
Y
E
G
M
V
E
E
A
R
K
I
H
G
L
G
D
N
A
V
V
A
I
P
M
T
E
D
G
L
R
A
I
K
T
L
S
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
Y
V
S
P
F
V
G
R
L
D
D
I
G
E
D
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
I
I
K
T
Q
I
L
V
A
S
I
R
N
P
I
H
V
L
R
S
A
V
I
G
A
D
V
V
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
K
V
S
P
D
59
PsiBlast_CBE
91.50
51%
-118
- C4 -
3S1X
2
TAL_THEAC
D:
[1-212]
M
K
I
F
L
D
T
A
N
I
D
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN
G
K
-
K
---
Y
G
D
I
I
R
E
I
L
K
I
V
D
G
P
V
S
V
E
V
V
S
T
K
Y
E
G
M
V
E
E
A
R
K
I
H
G
L
G
D
N
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
S
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
Y
V
S
P
F
V
G
R
L
D
D
I
G
E
D
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
I
I
K
T
Q
I
L
V
A
S
I
R
N
P
I
H
V
L
R
S
A
V
I
G
A
D
V
V
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
K
V
S
P
D
6
PsiBlast_PDB
91.44
51%
-116
- C4 -
3S1X
1
TAL_THEAC
A:
[1-212]
M
K
I
F
L
D
T
A
N
I
D
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN
G
K
-
K
---
Y
G
D
I
I
R
E
I
L
K
I
V
D
G
P
V
S
V
E
V
V
S
T
K
Y
E
G
M
V
E
E
A
R
K
I
H
G
L
G
D
N
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
S
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
Y
V
S
P
F
V
G
R
L
D
D
I
G
E
D
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
I
I
K
T
Q
I
L
V
A
S
I
R
N
P
I
H
V
L
R
S
A
V
I
G
A
D
V
V
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
K
V
S
P
D
71
PsiBlast_CBE
91.41
50%
-117
- C4 -
3S1W
2
TAL_THEAC
D:
[1-212]
M
K
I
F
L
D
T
A
N
I
D
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN
G
K
-
K
---
Y
G
D
I
I
R
E
I
L
K
I
V
D
G
P
V
S
V
E
V
V
S
T
K
Y
E
G
M
V
E
E
A
R
K
I
H
G
L
G
D
N
A
V
V
A
I
P
M
T
E
D
G
L
R
A
I
K
T
L
S
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
Y
V
S
P
F
V
G
R
L
D
D
I
G
E
D
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
I
I
K
T
Q
I
L
V
A
S
I
R
N
P
I
H
V
L
R
S
A
V
I
G
A
D
V
V
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
K
V
S
P
D
61
PsiBlast_CBE
91.36
51%
-116
- C4 -
3S1X
1
TAL_THEAC
B:
[1-212]
M
K
I
F
L
D
T
A
N
I
D
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN
G
K
-
K
---
Y
G
D
I
I
R
E
I
L
K
I
V
D
G
P
V
S
V
E
V
V
S
T
K
Y
E
G
M
V
E
E
A
R
K
I
H
G
L
G
D
N
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
S
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
Y
V
S
P
F
V
G
R
L
D
D
I
G
E
D
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
I
I
K
T
Q
I
L
V
A
S
I
R
N
P
I
H
V
L
R
S
A
V
I
G
A
D
V
V
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
K
V
S
P
D
86
HHSearch
91.10
50%
-115
- C4 -
3S1X
1
TAL_THEAC
A:
[1-217]
M
K
I
F
L
D
T
A
N
I
D
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
---
A
V
-
N
GKK
Y
G
D
I
I
R
E
I
L
K
I
V
D
G
P
V
S
V
E
V
V
S
T
K
Y
E
G
M
V
E
E
A
R
K
I
H
G
L
G
D
N
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
S
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
Y
V
S
P
F
V
G
R
L
D
D
I
G
E
D
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
I
I
K
T
Q
I
L
V
A
S
I
R
N
P
I
H
V
L
R
S
A
V
I
G
A
D
V
V
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
K
V
S
P
D
7
PsiBlast_PDB
90.92
50%
-116
- C4 -
3S1W
2
TAL_THEAC
A:
[1-212]
M
K
I
F
L
D
T
A
N
I
D
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN
G
K
-
K
---
Y
G
D
I
I
R
E
I
L
K
I
V
D
G
P
V
S
V
E
V
V
S
T
K
Y
E
G
M
V
E
E
A
R
K
I
H
G
L
G
D
N
A
V
V
A
I
P
M
T
E
D
G
L
R
A
I
K
T
L
S
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
Y
V
S
P
F
V
G
R
L
D
D
I
G
E
D
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
I
I
K
T
Q
I
L
V
A
S
I
R
N
P
I
H
V
L
R
S
A
V
I
G
A
D
V
V
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
K
V
S
P
D
5
PsiBlast_PDB
90.45
51%
-117
- C4 -
3S1V
3
TAL_THEAC
A:
[1-212]
M
K
I
F
L
D
T
A
N
I
D
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN
G
K
-
K
---
Y
G
D
I
I
R
E
I
L
K
I
V
D
G
P
V
S
V
E
V
V
S
T
K
Y
E
G
M
V
E
E
A
R
K
I
H
G
L
G
D
N
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
S
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
Y
V
S
P
F
V
G
R
L
D
D
I
G
E
D
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
I
I
K
T
Q
I
L
V
A
S
I
R
N
P
I
H
V
L
R
S
A
V
I
G
A
D
V
V
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
K
V
S
P
D