@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1912: (2015-12-11 )
MVELNLNHIYKKYPSASHYSVEDFDLDIKDKEFIVFVGPSGCGKSTTLRMIAGLEDISEGELKIDGEVVNDKSPKDRDIAMVFQNYALYPHMTVYDNMAFGLKLRKFSKQEIDKRVREAAANIGLTEFLERKPADLSGGQRQRVAMGRAIVRDAKVFLMDEPLSNLDAKLRVSMRAEIAKIHQRIGSTTIYVTHDQTEAMTLADRIVIMSATKNPDGDGTIGKIEQVGSPQELYNLPANKFVAGFIGSPSMNFFKVKVENGMIISEDGLRIAIPEGQEKLLESRGYKGKELIFGIRPEDISSNLLVQDTYPNANVEAEVLVSELLGSETMLYVKLGQTEFASRVEARDFHNPGEKVNLTFNVAKGHFFDADTEQAIR
Atome Classification :
(34 SA)
.........10........20........30........40........50........60.....-...70..------...-------...---------------80........90......-..100........110.......120.......130-.......140.......150.......160.......170.......180...---....190.......200.......210.......220.......230.......240.......250.---.....---.260----..----...---..270-.......280-......-..290.......300........--310....-.....320.......330......---.-340..-.....350.......360.......370.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
V
E
L
N
L
N
H
I
Y
K
KYPSASHY
S
V
E
D
F
DLDIKDK
E
F
I
V
F
VGPSGCGKS
T
T
L
R
M
I
AGLEDISEG
E
L
K
ID
G
-
E
VVNDKS------PKD-------
R
D
I
---------------
A
M
V
F
Q
NYALYPH
M
T
V
YDN-MAF
G
-
L
K
L
R
K
F
S
K
Q
E
I
D
K
R
V
R
E
A
A
ANI
G
L
T
E
F
L
E
RK-PADLSGG
Q
R
Q
R
V
A
M
G
R
A
I
VRD
A
K
V
F
L
MDEPLSNL
D
A
K
L
R
V
S
M
R
A
E
I
A
K
I
H
Q
RI---GS
T
T
I
Y
V
THDQT
E
A
M
T
L
A
D
R
I
V
I
M
S
ATKNPDGDGTI
G
K
I
E
QVG
S
P
Q
E
L
YNL
P
A
N
K
F
V
AGFIGSPSM
N
F
---
F
K
V
K
V---EN
G
M
----
I
I----SED---
G
L
R
I
A-IPE
G
Q
E
K
L
L
--
E
SRGYK-GK
E
L
I
F
G
IRPEDIS-S
N
L
L
V
Q
DT--Y--PNAN-
V
E
A
E
V
L
V
S
E
LLGSE
T
M
L
Y
V
KLG
Q
T
---
E
-
F
A
S
R
V
-
E
ARDFHNPG
E
K
V
N
L
T
F
N
VAKGHFFDAD
T
E
QAIR
3
PsiBlast_PDB
91.24
48%
-96
- C1 -
2D62
8
?
A:
[6-374]
--
E
V
K
L
I
N
I
W
K
R
F
G
D
V
T
--
A
V
K
D
L
S
L
E
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
R
G
Q
I
Y
I
E
D
-
N
L
V
A
D
P
E
KG
V
F
V
P
P
K
E
-------
R
D
V
---------------
A
M
V
F
Q
S
Y
A
L
Y
P
H
M
T
V
Y
D
N
-
I
A
F
P
-
L
K
L
R
K
V
P
K
Q
E
I
D
K
R
V
R
E
V
A
E
M
L
G
L
T
E
L
L
N
R
K
-
P
R
E
L
S
G
G
Q
R
Q
R
V
A
L
G
R
A
I
I
R
R
P
K
V
F
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
K
M
R
A
E
L
K
K
L
Q
R
Q
L
---
G
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
K
----------
G
E
L
Q
Q
V
G
T
P
D
E
V
Y
Y
K
P
V
N
T
F
V
A
G
F
I
G
S
P
P
M
N
F
---
L
D
A
T
I
---
T
D
D
G
----
F
L
----
D
F
G
---
E
F
K
L
K
-
L
L
Q
D
Q
F
E
V
L
--
E
E
E
N
M
V
-
G
K
E
V
I
F
G
I
R
P
E
D
V
H
-
D
A
S
F
T
H
I
D
--
V
--
P
E
E
N
T
V
K
A
T
V
D
I
I
E
N
L
G
G
E
K
I
V
H
L
R
R
G
N
I
---
S
-
F
T
A
K
F
-
P
K
E
S
K
V
R
E
G
D
E
V
S
V
V
F
D
M
K
K
I
H
I
F
R
K
D
T
E
K
A
I
F
5
PsiBlast_PDB
88.91
48%
-102
- C1 -
1V43
-
?
A:
[10-372]
M
V
E
V
K
L
E
N
L
T
K
R
F
--
G
N
F
T
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
D
-
R
D
V
T
Y
L
P
------
P
K
D
-------
R
N
I
---------------
S
M
V
F
Q
------
H
M
T
V
Y
E
N
-
I
A
F
P
-
L
--
K
K
F
P
K
D
E
I
D
K
R
V
R
W
A
A
E
L
L
Q
I
E
E
L
L
N
R
Y
-
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
---
K
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
----------
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
N
S
V
F
V
A
T
F
I
G
A
P
E
M
N
I
---
L
E
V
S
V
---
G
D
G
Y
-----
L
----
E
G
R
---
G
F
R
I
E
-
L
P
Q
--
M
D
L
L
----
K
D
Y
V
-
G
K
T
V
L
F
G
I
R
P
E
H
M
T
-
V
E
G
V
------
H
MK
R
T
A
R
-
L
I
G
K
V
D
F
V
E
A
L
G
T
D
T
I
L
H
V
K
F
G
D
E
---
L
-
V
K
V
K
L
-
P
G
H
I
P
I
E
P
G
R
E
V
K
V
I
M
D
L
D
M
I
H
V
F
D
K
D
T
E
K
A
I
V
1
PsiBlast_PDB
88.49
49%
-98
- C1 -
4TQU
-
?
S:
[2-362]
V
A
S
V
S
I
Q
N
V
V
K
R
Y
D
K
T
T
--
V
V
H
G
V
S
L
D
I
E
P
G
E
F
V
V
L
V
G
P
S
G
C
G
K
S
T
T
L
R
M
V
A
G
L
E
E
I
S
G
G
T
I
R
I
D
G
-
R
V
I
N
D
L
A
------
P
K
D
-------
R
D
V
---------------
A
M
V
F
Q
N
Y
A
L
Y
P
H
L
N
V
R
D
N
-
I
S
F
G
-
L
R
L
K
R
T
K
K
S
V
I
D
A
A
V
K
T
A
A
D
I
L
G
L
Q
P
L
L
E
R
K
-
P
S
D
L
S
G
G
Q
R
Q
R
V
A
M
G
R
A
I
V
R
D
P
K
V
F
L
F
D
Q
P
L
S
N
L
D
A
K
L
R
T
Q
M
R
A
E
I
K
R
L
H
Q
R
L
---
G
T
T
V
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
R
I
V
V
M
R
D
----------
G
L
I
E
Q
I
G
K
P
M
D
L
F
L
H
P
A
N
T
F
V
A
S
F
I
G
S
P
P
M
N
L
---
M
P
A
R
I
AVD
S
T
Q
H
----
V
E
----
L
N
G
---
G
N
R
I
S
L
L
P
R
A
G
T
H
L
-------
A
P
-
G
Q
E
V
V
F
G
I
R
P
E
D
V
T
-
L
D
G
V
--
E
G
--
S
--
E
R
A
Q
-
I
K
A
T
V
D
I
V
E
P
L
G
S
E
S
I
L
H
A
T
V
G
D
H
---
S
-
L
V
V
K
V
-
G
G
L
N
E
V
H
P
G
D
P
V
T
L
H
V
D
L
T
R
V
H
L
F
D
A
Q
S
Q
A
S
I
Y
111
HHSearch
88.22
50%
-97
- C1 -
1V43
-
?
A:
[10-372]
M
V
E
V
K
L
E
N
L
T
K
R
F
G
N
--
F
T
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
D
-
R
D
V
T
Y
L
P
------
P
K
D
-------
R
N
I
---------------
S
M
V
F
Q
------
H
M
T
V
Y
E
N
-
I
A
F
P
-
L
--
K
K
F
P
K
D
E
I
D
K
R
V
R
W
A
A
E
L
L
Q
I
E
E
L
L
N
R
Y
-
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
---
K
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
----------
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
N
S
V
F
V
A
T
F
I
G
A
P
E
M
N
I
---
L
E
V
S
V
---
G
D
G
Y
----
L
-----
E
G
R
---
G
F
R
I
---
E
L
P
Q
--
M
D
--
L
L
K
D
Y
V
-
G
K
T
V
L
F
G
I
R
P
E
H
M
T
-
V
E
G
V
----HM
K
--
R
T
A
R
-
L
I
G
K
V
D
F
V
E
A
L
G
T
D
T
I
L
H
V
K
F
G
D
E
---
L
-
V
K
V
K
L
-
P
G
H
I
P
I
E
P
G
R
E
V
K
V
I
M
D
L
D
M
I
H
V
F
D
K
D
T
E
K
A
I
V
4
PsiBlast_PDB
86.66
48%
-99
- C1 -
1VCI
1
?
A:
[10-372]
M
V
E
V
K
L
E
N
L
T
K
R
F
--
G
N
F
T
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
D
-
R
D
V
T
Y
L
P
------
P
K
D
-------
R
N
I
---------------
S
M
V
F
Q
------
H
M
T
V
Y
E
N
-
I
A
F
P
-
L
--
K
K
F
P
K
D
E
I
D
K
R
V
R
W
A
A
E
L
L
Q
I
E
E
L
L
N
R
Y
-
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
---
K
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
----------
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
N
S
V
F
V
A
T
F
I
G
A
P
E
M
N
I
---
L
E
V
S
V
---
G
D
G
Y
-----
L
----
E
G
R
---
G
F
R
I
E
-
L
P
Q
--
M
D
L
L
----
K
D
Y
V
-
G
K
T
V
L
F
G
I
R
P
E
H
M
T
-
V
E
G
V
------
H
MK
R
T
A
R
-
L
I
G
K
V
D
F
V
E
A
L
G
T
D
T
I
L
H
V
K
F
G
D
E
---
L
-
V
K
V
K
L
-
P
G
H
I
P
I
E
P
G
R
E
V
K
V
I
M
D
L
D
M
I
H
V
F
D
K
D
T
E
K
A
I
V
2
PsiBlast_PDB
85.65
49%
-97
- C1 -
4TQV
-
?
C:
[2-362]
V
A
S
V
S
I
Q
N
V
V
K
R
Y
D
K
T
T
--
V
V
H
G
V
S
L
D
I
E
P
G
E
F
V
V
L
V
G
P
S
G
C
G
K
S
T
T
L
R
M
V
A
G
L
E
E
I
S
G
G
T
I
R
I
D
G
-
R
V
I
N
D
L
A
------
P
K
D
-------
R
D
V
---------------
A
M
V
F
Q
N
Y
A
L
Y
P
H
L
N
V
R
D
N
-
I
S
F
G
-
L
R
L
K
R
T
K
K
S
V
I
D
A
A
V
K
T
A
A
D
I
L
G
L
Q
P
L
L
E
R
K
-
P
S
D
L
S
G
G
Q
R
Q
R
V
A
M
G
R
A
I
V
R
D
P
K
V
F
L
F
D
Q
P
L
S
N
L
D
A
K
L
R
T
Q
M
R
A
E
I
K
R
L
H
Q
R
L
---
G
T
T
V
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
R
I
V
V
M
R
D
----------
G
L
I
E
Q
I
G
K
P
M
D
L
F
L
H
P
A
N
T
F
V
A
S
F
I
G
S
P
P
M
N
L
---
M
P
A
R
I
A
VD
S
T
Q
H
----
V
E
----
L
N
G
---
G
N
R
I
S
L
L
P
R
A
G
T
H
L
-------
A
P
-
G
Q
E
V
V
F
G
I
R
P
E
D
V
T
-
L
D
G
V
--
E
G
--
S
--
E
R
A
Q
-
I
K
A
T
V
D
I
V
E
P
L
G
S
E
S
I
L
H
A
T
V
G
D
H
---
S
-
L
V
V
K
V
-
G
G
L
N
E
V
H
P
G
D
P
V
T
L
H
V
D
L
T
R
V
H
L
F
D
A
Q
S
Q
A
S
I
Y
116
HHSearch
83.78
47%
-84
- C1 -
3RLF
3
MALK_ECOLI
A:
[2-363]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
--
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
-
K
R
M
N
D
T
P
------
P
A
E
-------
R
G
V
---------------
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
-
M
S
F
G
-
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
R
K
-
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
---
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
----------
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
---
L
P
V
K
V
---
T
A
T
A
----
I
D
Q
V
Q
V
E
L
P
MPN
R
Q
Q
V
---
W
L
P
V
E
-----
S
R
D
V
Q
V
-
G
A
N
M
S
L
G
I
R
P
E
H
L
L
-
P
S
D
I
A
---------
D
V
I
-
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
R
Q
-
N
-
L
V
Y
R
Q
-
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
A
C
R
R
35
PsiBlast_CBE
83.20
41%
-98
- C1 -
2IT1
1
?
B:
[2-357]
-
V
E
I
K
L
E
N
I
V
K
K
F
--
G
N
F
T
A
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
Y
F
D
E
-
K
D
V
T
E
L
P
------
P
K
D
-------
R
N
V
---------------
G
L
V
F
Q
N
W
A
L
Y
P
H
M
T
V
Y
K
N
-
I
A
F
P
-
L
E
L
R
K
A
P
R
E
E
I
D
K
K
V
R
E
V
A
K
M
L
H
I
D
K
L
L
N
R
Y
-
P
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
A
E
L
K
R
L
Q
K
E
L
---
G
I
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
D
R
I
A
V
I
R
E
----------
G
E
I
L
Q
V
G
T
P
D
E
V
Y
Y
K
P
K
Y
K
F
V
G
G
F
L
G
N
P
P
M
N
F
---
V
E
A
K
V
---
E
D
G
K
----
L
V
----
I
T
E
---
K
S
K
L
P
-
I
P
K
Q
Y
V
E
I
V
--
K
E
T
G
I
---
T
E
V
I
I
G
F
R
P
H
D
A
E
----
I
V
K
G
E
------
G
E
G
-
I
V
G
E
V
Y
S
F
E
P
L
G
R
E
Q
I
V
T
V
S
V
N
D
S
I
V
K
V
-
F
A
P
E
G
-
E
H
F
S
F
---
G
E
K
V
T
I
K
V
K
E
E
L
L
V
L
F
D
K
K
T
E
K
A
L
E
14
PsiBlast_PDB
83.10
49%
-101
- C1 -
3PUV
5
MALK_ECOLI
A:
[2-320]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
--
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
-
K
R
M
N
D
T
P
------
P
A
E
-------
R
G
V
---------------
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
-
M
S
F
G
-
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
R
K
-
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
---
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
----------
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
---
L
P
V
K
V
----
T
A
T
----
A
I
----
D
Q
V
---
Q
V
E
L
P
-
M
P
N
R
Q
Q
V
W
L
PV
E
S
R
D
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
-----
H
L
L
P
S
D
I
--
A
---
D
V
I
-
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
---
R
-
Q
N
L
V
Y
-
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
A
C
112
HHSearch
82.21
43%
-86
- C1 -
2IT1
-
?
A:
[1-357]
M
V
E
I
K
L
E
N
I
V
K
K
F
G
N
--
F
T
A
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
Y
F
D
E
-
K
D
V
T
E
L
P
------
P
K
D
-------
R
N
V
---------------
G
L
V
F
Q
N
W
A
L
Y
P
H
M
T
V
Y
K
N
-
I
A
F
P
-
L
E
L
R
K
A
P
R
E
E
I
D
K
K
V
R
E
V
A
K
M
L
H
I
D
K
L
L
N
R
Y
-
P
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
A
E
L
K
R
L
Q
K
E
L
---
G
I
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
D
R
I
A
V
I
R
E
----------
G
E
I
L
Q
V
G
T
P
D
E
V
Y
Y
K
P
K
Y
K
F
V
G
G
F
L
G
N
P
P
M
N
F
---
V
E
A
K
V
---
E
D
G
K
----
L
V
----
I
T
E
---
K
S
K
L
---
P
I
P
K
Q
Y
V
E
--
I
V
K
E
T
G
-
I
T
E
V
I
I
G
F
R
P
H
D
A
E
-
I
V
K
G
E
---------
G
E
G
-
I
V
G
E
V
Y
S
F
E
P
L
G
R
E
Q
I
V
T
V
S
V
N
D
S
---
I
-
V
K
V
F
A
-
P
E
G
E
H
F
S
F
G
E
K
V
T
I
K
V
K
E
E
L
L
V
L
F
D
K
K
T
E
K
A
L
E
16
PsiBlast_PDB
81.51
49%
-102
- C1 -
3PUX
5
MALK_ECOLI
A:
[2-320]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
--
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
-
K
R
M
N
D
T
P
------
P
A
E
-------
R
G
V
---------------
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
-
M
S
F
G
-
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
R
K
-
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
---
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
----------
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
---
L
P
V
K
V
----
T
A
T
----
A
I
----
D
Q
V
---
Q
V
E
L
P
-
M
P
N
R
Q
Q
V
W
L
PV
E
S
R
D
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
-----
H
L
L
P
S
D
I
--
A
---
D
V
I
-
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
---
R
-
Q
N
L
V
Y
-
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
A
C
34
PsiBlast_CBE
81.50
44%
-100
- C1 -
2YYZ
3
?
A:
[18-358]
-------------------
A
V
D
G
V
S
F
E
V
K
D
G
E
F
V
A
L
L
G
P
S
G
C
G
K
T
T
T
L
L
M
L
A
G
I
Y
K
P
T
S
G
E
I
Y
F
D
D
-
V
L
V
N
D
I
P
------
P
K
Y
-------
R
E
V
---------------
G
M
V
F
Q
N
Y
A
L
Y
P
H
M
T
V
F
E
N
-
I
A
F
P
-
L
R
A
R
R
I
S
K
D
E
V
E
K
R
V
V
E
I
A
R
K
L
L
I
D
N
L
L
D
R
K
-
P
T
Q
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
Q
P
K
V
L
L
F
D
E
P
L
S
N
L
D
A
N
L
R
M
I
M
R
A
E
I
K
H
L
Q
Q
E
L
---
G
I
T
S
V
Y
V
T
H
D
Q
A
E
A
M
T
M
A
S
R
I
A
V
F
N
Q
----------
G
K
L
V
Q
Y
G
T
P
D
E
V
Y
D
S
P
K
N
M
F
V
A
S
F
I
G
N
P
P
T
N
F
L
R
D
F
S
V
S
V
---
E
N
K
Q
T
---
I
L
----
K
R
D
---
D
V
I
I
K
-
L
P
E
P
V
D
---------
V
K
-
L
K
E
V
V
V
G
I
R
P
E
H
C
R
I
S
R
E
R
V
E
N
S
--
I
--
P
G
V
------
V
Y
V
V
E
P
L
G
R
D
I
I
V
N
V
K
T
E
K
G
---
E
-
I
I
K
V
F
G
D
T
G
K
A
P
Q
P
G
E
N
V
F
L
V
P
D
L
R
K
I
H
L
F
N
P
E
T
E
E
T
I
L
15
PsiBlast_PDB
81.18
49%
-98
- C1 -
3PUW
5
MALK_ECOLI
A:
[2-320]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
--
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
-
K
R
M
N
D
T
P
------
P
A
E
-------
R
G
V
---------------
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
-
M
S
F
G
-
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
R
K
-
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
---
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
----------
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
---
L
P
V
K
V
----
T
A
T
----
A
I
----
D
Q
V
---
Q
V
E
L
P
-
M
P
N
R
Q
Q
V
W
L
PV
E
S
R
D
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
-----
H
L
L
P
S
D
I
--
A
---
D
V
I
-
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
---
R
-
Q
N
L
V
Y
-
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
A
C
20
PsiBlast_PDB
80.80
49%
-98
- C1 -
4KI0
4
?
A:
[2-320]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
--
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
-
K
R
M
N
D
T
P
------
P
A
E
-------
R
G
V
---------------
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
-
M
S
F
G
-
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
R
K
-
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
---
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
----------
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
---
L
P
V
K
V
----
T
A
T
----
A
I
----
D
Q
V
---
Q
V
E
L
P
-
M
P
N
R
Q
Q
V
W
L
PV
E
S
R
D
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
-----
H
L
L
P
S
D
I
--
A
---
D
V
I
-
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
---
R
-
Q
N
L
V
Y
-
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
A
C
11
PsiBlast_PDB
80.77
49%
-99
- C1 -
3PUY
3
MALK_ECOLI
A:
[2-320]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
--
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
-
K
R
M
N
D
T
P
------
P
A
E
-------
R
G
V
---------------
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
-
M
S
F
G
-
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
R
K
-
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
---
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
----------
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
---
L
P
V
K
V
----
T
A
T
----
A
I
----
D
Q
V
---
Q
V
E
L
P
-
M
P
N
R
Q
Q
V
W
L
PV
E
S
R
D
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
-----
H
L
L
P
S
D
I
--
A
---
D
V
I
-
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
---
R
-
Q
N
L
V
Y
-
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
A
C
114
HHSearch
80.01
44%
-88
- C1 -
2YYZ
3
?
A:
[2-358]
-
P
S
I
R
V
V
N
L
K
K
Y
F
G
K
--
V
K
A
V
D
G
V
S
F
E
V
K
D
G
E
F
V
A
L
L
G
P
S
G
C
G
K
T
T
T
L
L
M
L
A
G
I
Y
K
P
T
S
G
E
I
Y
F
D
D
-
V
L
V
N
D
I
P
------
P
K
Y
-------
R
E
V
---------------
G
M
V
F
Q
N
Y
A
L
Y
P
H
M
T
V
F
E
N
-
I
A
F
P
-
L
R
A
R
R
I
S
K
D
E
V
E
K
R
V
V
E
I
A
R
K
L
L
I
D
N
L
L
D
R
K
-
P
T
Q
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
Q
P
K
V
L
L
F
D
E
P
L
S
N
L
D
A
N
L
R
M
I
M
R
A
E
I
K
H
L
Q
Q
E
L
---
G
I
T
S
V
Y
V
T
H
D
Q
A
E
A
M
T
M
A
S
R
I
A
V
F
N
Q
----------
G
K
L
V
Q
Y
G
T
P
D
E
V
Y
D
S
P
K
N
M
F
V
A
S
F
I
G
N
P
P
T
N
F
---
L
R
D
F
S
---
V
S
V
E
NK
Q
T
I
L
----
K
R
D
---
D
V
I
I
---
K
L
P
E
-------
P
V
D
V
K
-
L
K
E
V
V
V
G
I
R
P
E
H
C
R
-
I
S
R
E
R
--------
V
E
N
S
-
I
P
G
V
V
Y
V
V
E
P
L
G
R
D
I
I
V
N
V
K
T
E
K
G
---
E
I
I
K
V
F
G
-
D
T
G
K
A
P
Q
P
G
E
N
V
F
L
V
P
D
L
R
K
I
H
L
F
N
P
E
T
E
E
T
I
L
17
PsiBlast_PDB
79.90
49%
-100
- C1 -
3RLF
3
MALK_ECOLI
A:
[2-320]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
--
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
-
K
R
M
N
D
T
P
------
P
A
E
-------
R
G
V
---------------
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
-
M
S
F
G
-
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
R
K
-
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
---
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
----------
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
---
L
P
V
K
V
----
T
A
T
----
A
I
----
D
Q
V
---
Q
V
E
L
P
-
M
P
N
R
Q
Q
V
W
L
PV
E
S
R
D
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
-----
H
L
L
P
S
D
I
--
A
---
D
V
I
-
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
---
R
-
Q
N
L
V
Y
-
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
A
C
33
PsiBlast_CBE
79.70
49%
-94
- C1 -
2R6G
2
MALK_ECOLI (first)
A:
[2-320]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
--
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
-
K
R
M
N
D
T
P
------
P
A
E
-------
R
G
V
---------------
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
-
M
S
F
G
-
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
R
K
-
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
Q
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
---
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
----------
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
---
L
P
V
K
V
----
T
A
T
----
A
I
----
D
Q
V
---
Q
V
E
L
P
-
M
P
N
R
Q
Q
V
W
L
PV
E
S
R
D
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
-----
H
L
L
P
S
D
I
--
A
---
D
V
I
-
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
---
R
-
Q
N
L
V
Y
-
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
A
C
22
PsiBlast_CBE
79.64
49%
-101
- C1 -
3RLF
3
MALK_ECOLI
B:
[2-320]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
--
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
-
K
R
M
N
D
T
P
------
P
A
E
-------
R
G
V
---------------
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
-
M
S
F
G
-
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
R
K
-
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
---
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
----------
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
---
L
P
V
K
V
----
T
A
T
----
A
I
----
D
Q
V
---
Q
V
E
L
P
-
M
P
N
R
Q
Q
V
W
L
PV
E
S
R
D
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
-----
H
L
L
P
S
D
I
--
A
---
D
V
I
-
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
---
R
-
Q
N
L
V
Y
-
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
A
C
32
PsiBlast_CBE
79.46
49%
-98
- C1 -
2R6G
2
MALK_ECOLI (first)
B:
[2-320]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
--
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
-
K
R
M
N
D
T
P
------
P
A
E
-------
R
G
V
---------------
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
-
M
S
F
G
-
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
R
K
-
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
Q
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
---
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
----------
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
---
L
P
V
K
V
----
T
A
T
----
A
I
----
D
Q
V
---
Q
V
E
L
P
-
M
P
N
R
Q
Q
V
W
L
PV
E
S
R
D
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
-----
H
L
L
P
S
D
I
--
A
---
D
V
I
-
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
---
R
-
Q
N
L
V
Y
-
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
A
C
59
PsiBlast_CBE
58.49
35%
-96
- C1 -
3C4J
4
?
B:
[40-259]
--------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
---
I
N
L
K
A
-------
K
D
TNLNKVR
E
E
V
---------------
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
-
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
----
M
V
G
E
V
L
S
V
M
K
Q
L
ANE
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
------
D
G
----
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
57.51
35%
-89
- C1 -
3C4J
3
?
A:
[40-259]
--------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
---
I
N
L
K
A
-------
K
D
TN
L
N
K
V
R
E
E
V
---------------
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
-
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
----
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
------
D
G
----
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
56.90
35%
-91
- C1 -
2OLK
1
?
D:
[40-259]
--------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
---
I
N
L
K
A
-------
K
D
TNLNKVR
E
E
V
---------------
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
-
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
----
M
V
G
E
V
L
S
V
M
K
Q
L
ANE
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
------
D
G
----
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
56.84
35%
-95
- C1 -
2OLK
1
?
A:
[40-259]
--------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
---
I
N
L
K
A
-------
K
D
T
N
L
N
K
V
R
E
E
V
---------------
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
-
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
----
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
------
D
G
----
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
56.08
35%
-90
- C1 -
2Q0H
4
?
A:
[40-259]
--------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
---
I
N
L
K
A
-------
K
D
TN
L
N
K
V
R
E
E
V
---------------
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
-
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
----
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
------
D
G
----
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
56.05
35%
-93
- C1 -
2OLK
1
?
C:
[40-259]
--------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
---
I
N
L
K
A
-------
K
D
TNLNKVR
E
E
V
---------------
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
-
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
----
M
V
G
E
V
L
S
V
M
K
Q
L
ANE
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
------
D
G
----
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
55.91
35%
-92
- C1 -
2OLK
2
?
B:
[40-259]
--------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
---
I
N
L
K
A
-------
K
D
TNLNKVR
E
E
V
---------------
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
-
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
----
M
V
G
E
V
L
S
V
M
K
Q
L
ANE
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
------
D
G
----
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
55.82
35%
-94
- C1 -
3C41
3
?
K:
[23-238]
------------------------
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
---
I
N
L
K
A
-------
K
D
TNLNKVR
E
E
V
---------------
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
-
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
----
M
V
G
E
V
L
S
V
M
K
Q
L
ANE
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
------
D
G
----
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
55.65
35%
-92
- C1 -
2OLJ
4
?
A:
[40-259]
--------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
---
I
N
L
K
A
-------
K
D
TN
L
N
K
V
R
E
E
V
---------------
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
-
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
----
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
------
D
G
----
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
54.72
35%
-86
- C1 -
2OLJ
3
?
B:
[40-259]
--------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
---
I
N
L
K
A
-------
K
D
TNLNKVR
E
E
V
---------------
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
-
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
----
M
V
G
E
V
L
S
V
M
K
Q
L
ANE
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
------
D
G
----
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
54.32
35%
-94
- C1 -
2Q0H
4
?
B:
[40-259]
--------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
---
I
N
L
K
A
-------
K
D
TNL
N
K
V
R
E
E
V
---------------
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
-
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
----
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
------
D
G
----
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
54.27
35%
-86
- C1 -
3C41
3
?
J:
[23-238]
------------------------
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
---
I
N
L
K
A
-------
K
D
TNLNKVR
E
E
V
---------------
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
-
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
----
M
V
G
E
V
L
S
V
M
K
Q
L
ANE
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
------
D
G
----
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
54.14
33%
-90
- C1 -
4U00
3
?
A:
[5-238]
---
I
R
I
R
N
L
H
K
W
F
--
G
P
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
K
D
D
R
A
------
L
R
E
I
R
-----
R
E
V
---------------
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
-
V
T
L
A
P
M
R
V
R
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
Q
A
R
K
Y
-
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
-
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
---
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
------
D
G
----
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
L
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
41.81
31%
-72
- C1 -
1B0U
4
HISP_SALTY
A:
[45-253]
-------------------------------------------
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
-
Q
N
I
N
L
V
R
------
D
K
D
-------
G
Q
L
KVAD
K
N
Q
L
R
L
L
R
T
R
L
T
M
V
F
Q
H
F
N
L
W
S
H
M
T
V
L
E
N
V
M
E
A
P
-
I
Q
V
L
G
L
S
K
H
D
A
R
E
R
A
L
K
Y
L
A
K
V
G
I
D
E
R
A
Q
G
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
----
V
G
E
V
L
R
I
M
Q
Q
L
A
E
E
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
----------
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
S
P
R
L
Q
Q
F
L
K
G
S
L
K
K
L
---
E
H
-------------------------------------------------------------------------------------------------------------------------------------------------------