@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu02950: (2016-06-05 )
MGKQQPISQRKLLGVAGLGWLFDAMDVGILSFIIAALHVEWNLSPEEMKWIGSVNSIGMAAGAFLFGLLADRIGRKKVFIITLLCFSIGSGISAFVTSLSAFLILRFVIGMGLGGELPVASTLVSEAVVPEKRGRVIVLLESFWAVGWLAAALISYFVIPSFGWQAALLLTALTAFYALYLRTSLPDSPKYESLSAKKRSMWENVKSVWARQYIRPTVMLSIVWFCVVFSYYGMFLWLPSVMLLKGFSMIQSFEYVLLMTLAQLPGYFSAAWLIEKAGRKWILVVYLIGTAGSAYFFGTADSLSLLLTAGVLLSFFNLGAWGVLYAYTPEQYPTAIRATGSGTTAAFGRIGGIFGPLLVGTLAARHISFSVIFSIFCIAILLAVACILIMGKETKQTELE
Atome Classification :
(20 SA)
--------------.........10...-.....20........30.......-.40---.--------.--------------.------.-----.....50...---..----------...60........70........80........90.---..------------------.------------------.---.----.-------.100------------.........110.......120.......130.......140.....-..150...--...--------.----------------------------160------------------------.--------------.--------------.....-..170...-...-.-180........-------190-----------------------------..---.---.---..-..----------------200------------------------------.----------------.----.----...---...210-.-..--..-.-..-------------220---.-.-----------------------..----....-230...---..-------...240-----------...--..---..250---------..---......260.----------......270....-----...280...-...---.290.-------.....-------.--300---.---------.-----.---.---.....-310....-..-.-320--..-.......330.......340......-----.350---.-.......360.......370---..-.....380.......---390-........400-----------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------MGKQQPI
S
Q
RKLLG-VA
G
L
G
W
L
F
D
A
M
D
V
G
I
L
S
F
I
I
A
A
L
H
-
V
E
----W--------N--------------L------
S
-----
P
E
E
M
K
W
I
GSV---N
S
----------
I
G
M
A
A
G
A
F
L
F
G
L
L
A
D
RIGR
K
K
V
F
I
I
T
L
L
C
F
SIGS
G
I
---
S
A
------------------
F
------------------
V
---
T
----
S
-------
L
S
--------------
A
F
L
I
L
R
F
V
I
GMGLGGEL
P
V
A
S
T
L
V
S
E
AVVPEKR
G
R
V
I
V
L
L
E
S
F
W
A
V
G
-
W
L
A
A
A
L
I
S
--
Y
F
V--------I----------------------------P--------------------------S--------------F--------------G
W
Q
A
A
-
L
L
L
T
A
L
T
A
-
F
Y
A
-
L
-
Y
-
L
RTSLPDSP-------K
Y
------------------------------
E
S
---
L
---
S
---
A
K
-
K
R
----------------
S
--------------------------------
M
----------------
W
----
E
----
N
V
K
---
S
V
W
A
R
--
Q
-YI--
R
P
-
T
-
V
M
-------------
L
S
----
I
-
V
-----------------------
W
F
----
C
V
V
F
-
S
-
Y
Y
G
M
---
F
L
-------
W
L
P
S
V
M
-----------
L
L
K
--
G
F
---
S
M
I
Q
----------
S
F
---
E
Y
V
L
L
M
T
L
A
Q----------LP
G
Y
F
S
A
A
W
L
I
E
K-----AG
R
K
W
I
L
V
V
-
Y
L
I---GTAG
S
-------
A
Y
F
F
G-------T--
A
-----
D
---------
S
-----
L
---
S
---
L
L
L
T
A
-
G
V
L
L
S
F
F
-NL-G-A----
W
G
-
V
L
Y
A
YTPEQYP
T
A
I
R
ATGSGT
T
A
A
F
G
-----
R
I
G
----
G
-
I
F
G
P
L
L
V
G
T
L
A
A
R
H
I
S
F
S
V
I
---
F
S
-
I
F
C
I
A
I
L
L
A
V
A
C
I
L
I---MG--KETKQTELE-------------------------------------------------------
31
HHSearch
84.50
27%
-158
- C3 -
4J05
1
?
A:
[32-507]
---------------------
P
Q
I
K
L
V
L
-
L
A
G
V
G
F
F
L
D
A
Y
D
L
F
I
I
N
Q
V
A
P
M
L
A
-
Q
V
YFPK
T
--------
G
--------------
L
------
P
-----
A
Q
R
Q
D
L
M
K
A
A
---
A
N
----------
I
G
C
V
V
G
Q
V
M
F
G
V
L
G
D
S
F
G
R
K
F
V
Y
G
K
E
L
I
L
I
I
V
A
T
I
F
---
Q
M
------------------
S
------------------
A
---
P
----
S
HWD
G
N
R
V
L
T
--------------
W
I
T
I
C
R
V
F
L
G
I
G
I
G
G
D
Y
P
M
S
A
T
V
V
S
D
R
A
N
I
H
R
R
G
T
L
L
C
F
I
F
A
N
Q
G
W
G
-
S
F
V
G
S
L
V
T
--
I
V
T
--------
I
----------------------------
S
--------------------------
G
F
K
H
RLKSGHTHD
V
D
K
--------------
A
W
R
I
L
-
I
G
L
S
L
I
P
A
-
F
G
T
-
L
-
Y
-
Q
R
---------------------------------------------------------------------------------------------------------------------------------------------
W
Q
E
F
V
A
Y
F
S
T
--
W
N
H
F
--
R
N
-
L
-
L
G
-------------
S
M
----
L
-
G
-----------------------
W
F
----
L
V
D
I
-
A
-
F
Y
G
I
---
N
L
-------
N
Q
S
V
V
L
-----------
A
Q
I
--
G
F
---
A
G
K
T
GD
V
Y
D
K
L
F
Q
L
A
T
---
G
N
I
I
V
T
A
L
G
F
----------
L
P
G
Y
Y
F
T
L
F
L
I
D
I
-----
V
G
R
K
K
L
Q
F
M
-
G
F
I
---
M
S
G
L
F
-------
L
A
I
L
A
-------
G
E
-
I
-----
D
---------
H
IG---
K
G
--
P
---
L
L
A
C
F
-
T
F
M
Q
F
F
F
-
N
F
-
G
-
A
----
N
T
-
T
T
F
I
V
A
A
E
L
F
P
T
R
I
R
A
S
A
H
G
I
S
A
A
A
G
-----
K
C
G
----
A
-
I
L
S
S
L
V
F
N
Q
L
K
A
K
-
I
G
T
S
A
V
---
L
W
-
I
F
F
S
T
C
I
L
G
F
I
S
T
F
L
---
I
---
D
E
T
M
G
V
----------------------------------------------------------
1
PsiBlast_PDB
83.38
24%
-156
- C3 -
4J05
1
?
A:
[33-515]
----------------------
Q
I
K
L
V
L
-
L
A
G
V
G
F
F
L
D
A
Y
D
L
F
I
I
N
Q
V
A
P
M
L
A
-
Q
V
----
Y
FPKT----
G
--------------
L
------
P
-----
A
Q
R
Q
D
L
M
K
A
A
---
A
N
----------
I
G
C
V
V
G
Q
V
M
F
G
V
L
G
D
S
F
G
R
K
F
V
Y
G
K
E
L
I
L
I
I
V
A
T
I
F
---
Q
M
------------------
S
------------------
A
---
P
----
S
HWD
G
N
R
V
L
T
--------------
W
I
T
I
C
R
V
F
L
G
I
G
I
G
G
D
Y
P
M
S
A
T
V
V
S
D
R
A
N
I
H
R
R
G
T
L
L
C
F
I
F
A
N
Q
G
W
G
-
S
F
V
G
S
L
V
T
--
I
V
T
--------
I
----------------------------
S
--------------------------
G
--------------
F
K
H
RLKSGHTHD
V
D
K
A
W
R
I
L
-
I
G
L
S
L
I
P
A
-
F
G
T
-
L
-
Y
-
Q
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WQE
F
V
A
Y
F
STWNHF
R
N
L
L
G
S
M
L
G
W
F
----
L
V
D
I
-
A
-
F
Y
G
I
---
N
L
-------
N
Q
S
V
V
L
-----------
A
Q
I
--
G
F
---
A
G
K
T
----------
G
D
---
V
Y
D
K
L
F
Q
L
A
T
G
N
I
I
V
T
A
L
G
F
L
P
G
Y
Y
F
T
L
F
L
I
D
I
-----
V
G
R
K
K
L
Q
F
M
G
F
I
M
---
S
G
L
F
L
-------
A
I
L
A
G
-------
E
--
I
-----
D
---------
H
-----
I
---
G
K
G
P
L
L
A
C
F
-
T
F
M
Q
F
F
F
-
N
F
-
G
-
A
----
N
T
-
T
T
F
I
V
A
A
E
L
F
P
T
R
I
R
A
S
A
H
G
I
S
A
A
A
G
-----
K
C
G
----
A
-
I
L
S
S
L
V
F
N
Q
L
K
A
K
I
G
T
S
A
V
L
---
W
I
-
F
F
S
T
C
I
L
G
F
I
S
T
F
L
I
DET
M
G
--
V
D
P
D
E
K
D
L
E
-------------------------------------------------------
26
Fugue
83.28
19%
-156
- C3 -
3WDO
-
?
A:
[3-455]
-----------DYK
M
T
P
G
E
R
R
A
T
W
G
L
G
T
-
V
F
S
L
R
M
L
G
M
F
M
V
L
P
V
L
T
T
Y
G
M
A
L
Q
----------------
G
--------------
A
------
S
-----
E
A
L
I
G
I
A
I
G
I
---
Y
G
----------
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
I
G
R
K
P
L
I
V
G
G
L
A
V
F
A
A
G
S
V
I
---
A
A
------------------
L
------------------
S
---
D
----
S
-------
I
W
--------------
G
I
I
L
G
R
A
L
Q
G
S
G
A
I
--
A
A
A
V
M
A
L
L
S
D
L
T
R
E
Q
N
R
T
K
A
M
A
F
I
G
V
S
F
G
I
T
-
F
A
I
A
M
V
L
G
--
P
I
I
--------
T
----------------------------
H
--------------------------
K
--------------
L
--------------
G
L
H
A
L
-
F
W
M
I
A
I
L
A
-
T
T
G
-
I
-
A
-
L
T
I
W
V
V
P
N
S
-------
S
T
------------------------------
H
V
---
L
---
N
---
R
E
-
S
G
----------------
M
--------------------------------
V
----------------
K
----
G
----
S
F
S
---
K
V
L
A
E
--------
P
R
-
L
-
L
K
-------------
L
N
----
F
-
G
-----------------------
I
M
----
C
L
H
M
-
L
-
L
M
S
T
---
F
V
-------
A
L
P
G
Q
L
-----------
A
D
A
--
G
F
P
A
A
E
H
W
K
----------
V
Y
---
L
A
T
M
L
I
A
F
G
S
----------
V
V
P
F
I
I
Y
A
E
V
K
R
K
-----
M
K
Q
V
F
V
F
C
V
-
G
L
I
---
V
V
A
E
I
-------
V
L
W
N
A
-------
Q
--
T
-----
Q
---------
F
-----
W
---
Q
---
L
V
V
G
V
-
Q
L
F
F
V
A
F
-
N
L
---
M
----
E
A
-
L
L
P
S
L
I
S
K
E
S
P
A
G
Y
K
G
T
A
M
G
V
Y
S
T
S
Q
-----
F
L
G
----
V
-
A
I
G
G
S
L
G
G
W
I
D
G
M
F
D
G
Q
G
V
F
---
L
A
G
A
M
L
A
A
V
W
L
A
V
A
S
T
M
K
---
E
P
--
P
Y
V
S
S
L
R
I
E
IPADIAAN
E
A
L
K
V
R
L
L
E
TEGVK
E
V
L
I
AEEEH
S
A
Y
V
K
I
DSKVTN
R
F
E
V
E
Q
A
I
R
QAL
32
HHSearch
82.36
23%
-162
* C3 *
4LDS
-
?
A:
[7-409]
------------------------
L
I
F
I
-
L
G
A
L
G
G
L
L
Y
G
Y
D
N
G
V
I
S
G
A
L
L
F
I
H
-
K
D
----
I
--------
P
--------------
L
------
N
-----
S
T
T
E
G
I
V
V
S
S
---
M
L
----------
I
G
A
I
V
G
A
G
S
S
G
P
L
A
D
K
L
G
R
R
R
L
V
M
L
I
A
I
V
F
I
I
G
A
L
I
---
L
A
------------------
A
------------------
S
---
T
----
N
-------
L
A
--------------
L
L
I
I
G
R
L
I
I
G
L
A
V
G
G
S
M
S
T
V
P
V
Y
L
S
E
M
A
P
T
E
Y
R
G
S
L
G
S
L
N
Q
L
M
I
T
I
G
-
I
L
A
A
Y
L
V
N
--
Y
A
F
--------
A
----------------------------
D
--------------------------
I
--------------
E
--------------
G
W
R
W
M
-
L
G
L
A
V
V
P
S
-
V
I
L
-
L
-
V
-
G
I
Y
F
M
P
E
S
P
-------
R
W
------------------------------
L
L
---
E
---
N
---
R
N
-
E
E
A
A
R
Q
V
M
K
I
T
YDDSE
I
D
K
--------------------------------
E
L
K
E
M
K
E
----------
I
----
N
A
I
S
E
S
T
W
---
T
V
I
K
S
--
P
-
W
L
--
G
R
-
I
-
L
I
-------------
V
G
----
C
I
F
-----------------------
A
I
----
F
Q
Q
F
I
G
-
I
N
A
V
---
I
F
-------
Y
S
S
S
I
F
-----------
A
K
A
--
G
L
---
G
E
A
A
----------
S
I
---
L
G
S
V
G
I
G
T
I
N
----------
V
L
V
T
I
V
A
I
F
V
V
D
K
-----
I
D
R
K
K
L
L
V
G
-
G
N
I
---
G
M
I
A
S
-------
L
L
I
M
A
I
L
I
W
T
IG
I
--
A
-----
S
---------
S
-----
A
---
W
---
I
I
I
V
C
-
L
S
L
F
I
V
F
-
F
G
-
I
S
W
----
G
P
-
V
L
W
V
M
L
P
E
L
F
P
M
R
A
R
G
A
A
T
G
I
S
A
L
V
L
-----
N
I
G
----
T
-
L
I
V
S
L
F
F
P
I
L
S
D
A
-
L
S
T
E
W
V
---
F
L
-
I
F
A
F
----------------------------------------------------------------------------------
22
Fugue
78.87
21%
-147
- C3 -
4GC0
5
XYLE_ECOLI
A:
[5-479]
-----------------
Y
N
S
S
Y
I
F
S
I
T
L
-
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
-
T
V
----
F
VAPQNLS
E
S
--------------
A
------
A
-----
N
S
L
L
G
F
C
V
A
S
---
A
L
----------
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
V
G
---
S
A
WPELGFTSINPDNTVPVY
L
------------------
A
---
G
----
Y
-------
V
P
--------------
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
-
Q
L
L
V
Y
C
V
N
--
Y
F
I
--------
A
----------------------------
R
--------------------------
S
GD
A
S
W
L
N
T
------
D
--------------
G
W
R
Y
M
-
F
A
S
E
C
I
P
A
-
L
L
F
-
L
-
M
-
L
L
Y
T
V
P
E
S
P
-------
R
W
L
M
S
R
GK
Q
E
Q
A
E
G
I
L
R
K
I
MG
N
T
L
A
T
------
Q
A
---
V
---
Q
---
E
I
-
K
H
----------------
S
--------------------------------
L
----------------
D
----
H
----
G
R
K
---
T
G
G
R
L
--
L
-
M
F
--
G
V
-
G
-
V
I
-------------
V
I
----
G
-
V
-----------------------
M
L
----
S
I
F
Q
-
Q
-
F
V
G
I
N
V
V
L
Y
-------
Y
A
P
E
V
F
-----------
K
T
L
--
G
A
---
S
T
D
I
----------
A
L
---
L
Q
T
I
I
V
G
V
I
N
----------
L
T
F
T
V
L
A
I
M
T
V
D
K
-----
F
G
R
K
P
L
Q
I
I
-
G
A
L
---
G
M
A
I
G
-------
M
F
S
L
G
-------
T
--
A
-----
F
Y
T
QAP----
G
-----
I
---
V
---
A
L
L
S
M
-
L
F
Y
V
A
A
F
-
A
M
-
S
-
W
----
G
P
-
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
----
W
-
T
F
P
M
M
D
K
N
S
W
L
V
A
H
F
H
N
G
F
S
---
Y
W
-
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
---
F
V
--
P
E
T
K
G
K
T
L
E
ELEALWE------------------------------------------------
24
Fugue
78.77
21%
-175
- C3 -
4QIQ
1
XYLE_ECOLI
A:
[7-470]
--------------------
S
Y
I
F
S
I
T
L
-
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
-
T
V
----
F
--------
V
--------------
A
------
P
QNLS
E
S
A
A
N
S
L
L
G
F
C
V
A
S
A
L
----------
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
V
G
---
S
A
WPELGFTSINPDNTVPVY
L
------------------
A
---
G
----
Y
-------
V
P
--------------
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
-
Q
L
L
V
Y
C
V
N
--
Y
F
I
A
R
SGD
A
S
W
L
----------------------------
N
--------------------------
T
--------------
D
--------------
G
W
R
Y
M
-
F
A
S
E
C
I
P
A
-
L
L
F
-
L
-
M
-
L
L
Y
T
V
P
E
S
P
-------
R
W
LMT
L
--------------------------
A
T
---
Q
---
A
---
V
Q
-
E
I
----------------
K
--------------------------------
H
----------------
S
----
L
----
D
R
L
---
L
M
F
G
V
--
G
-
V
I
--
V
I
-
G
-
V
M
-------------
L
S
----
I
-
F
-----------------------
Q
Q
----
F
V
---
G
-
I
N
V
V
---
L
Y
-------
Y
A
P
E
V
F
-----------
K
T
L
--
G
A
---
S
T
D
I
----------
A
L
---
L
Q
T
I
I
V
G
V
I
N
----------
L
T
F
T
V
L
A
I
M
T
V
D
K
-----
F
G
R
K
P
L
Q
I
I
-
G
A
L
---
G
M
A
I
G
-------
M
F
S
L
G
-------
T
--
A
-----
F
---------
Y
T
QAP
G
I
---
V
---
A
L
L
S
M
-
L
F
Y
V
A
A
F
-
A
M
-
S
-
W
----
G
P
-
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
-----
W
L
A
----
N
-
Y
F
V
S
W
T
F
P
M
M
D
K
N
S
W
L
V
A
H
F
HNG
F
S
-
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
---
W
K
FV
P
E
T
K
G
K
T
L
--------------------------------------------------------
2
PsiBlast_PDB
77.35
23%
-161
- C3 -
4LDS
-
?
A:
[22-427]
----------------------------------------
D
N
G
V
I
S
G
A
L
L
F
I
H
-
K
D
----
I
--------
P
--------------
L
------
N
-----
S
T
T
E
G
I
V
V
S
S
---
M
L
----------
I
G
A
I
V
G
A
G
S
S
G
P
L
A
D
K
L
G
R
R
R
L
V
M
L
I
A
I
V
F
I
I
G
A
L
I
---
L
A
------------------
A
------------------
S
---
T
----
N
-------
L
A
--------------
L
L
I
I
G
R
L
I
I
G
L
A
V
G
G
S
M
S
T
V
P
V
Y
L
S
E
M
A
P
T
E
Y
R
G
S
L
G
S
L
N
Q
L
M
I
T
I
G
-
I
L
A
A
Y
L
V
N
--
Y
A
F
--------
A
----------------------------
D
--------------------------
I
--------------
E
--------------
G
W
R
W
M
-
L
G
L
A
V
V
P
S
-
V
I
L
-
L
-
V
-
G
I
Y
F
M
P
E
S
P
-------
R
W
L
L
E
N
RNE
E
A
A
R
Q
V
M
K
I
T
YDDSE
I
D
K
E
L
K
E
M
K
E
---
I
---
N
---
A
I
-
S
E
----------------
S
--------------------------------
T
----------------
W
----
T
----
V
I
K
---
S
P
W
L
G
--
R
-------------------------------
I
-
L
-----------------------
I
V
----
G
C
I
F
-
A
-
I
F
Q
Q
---
F
I
-------
G
I
N
A
V
I
FYSSSIFAKAG
L
G
E
--
A
A
---
S
I
L
G
----------
S
V
---
G
I
G
T
I
N
V
L
V
T
----------
I
V
A
I
F
----
V
V
D
K
-----
I
D
R
K
K
L
L
V
G
-
G
N
I
---
G
M
I
A
S
L
L
I
M
A
I
L
I
W
T
I
G
-------
I
--
A
-----
S
---------
S
-----
A
---
W
---
I
I
I
V
C
L
S
L
F
I
V
F
F
-
G
I
---
S
----
W
G
P
V
L
W
V
M
L
P
E
L
F
P
M
R
A
R
G
A
A
T
G
I
S
A
L
V
L
-----
N
I
G
T
L
I
V
S
-
L
F
F
P
I
L
S
D
A
L
S
T
E
W
-----
V
---
F
L
-
I
F
A
F
I
G
V
L
A
M
I
F
V
I
K
---
F
L
--
P
E
T
R
G
-----------------------------------------------------------
34
HHSearch
76.42
19%
-140
- C3 -
4GC0
5
XYLE_ECOLI
A:
[5-430]
-----------------
Y
N
S
S
Y
I
F
S
I
T
L
-
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
-
T
V
----
F
VAPQNLS
E
S
--------------
A
------
A
-----
N
S
L
L
G
F
C
V
A
S
---
A
L
----------
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
V
G
---
S
A
------------------
W
PELGFTSINPDNTVPVYL
A
---
G
----
Y
-------
V
P
--------------
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
-
Q
L
L
V
Y
C
V
N
--
Y
F
I
--------
A
----------------------------
R
S
GD
A
S
W
L
N
------------------
T
--------------
D
--------------
G
W
R
Y
M
-
F
A
S
E
C
I
P
A
-
L
L
F
-
L
-
M
-
L
L
Y
T
V
P
E
S
P
-------
R
W
------------------------------
L
M
---
S
---
R
---
G
K
-
Q
E
----------------
Q
--------------------------------
A
E
G
I
L
R
K
I
MG
N
T
L
A
T
Q
A
V
----
Q
----
E
I
K
---
H
S
L
D
H
G
R
K
-
T
G
--
G
R
-
L
-
L
M
-------------
F
G
VG
V
I
V
-
I
G
----------------------
V
M
L
S
I
F
Q
Q
F
V
-
G
-
I
N
V
V
---
L
Y
-------
Y
A
P
E
V
F
-----------
K
T
L
--
G
A
---
S
T
D
I
----------
A
L
---
L
Q
T
I
I
V
G
V
I
N
----------
L
T
F
T
V
L
A
I
M
T
V
D
K
-----
F
G
R
K
P
L
Q
I
I
-
G
A
L
---
G
M
A
I
G
-------
M
F
S
L
G
-------
T
--
A
F
Y
T
--
Q
A--------
P
-----
G
---
I
---
V
A
L
L
S
-
M
L
F
Y
V
A
A
F
A
M
-
S
-
W
----
G
P
-
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
-----
W
L
A
----
N
-
Y
F
V
S
W
T
F
P
M
M
D
-----------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
74.84
21%
-143
- C3 -
4GC0
4
XYLE_ECOLI
A:
[16-404]
-----------------------------
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
-
T
V
----
F
-----------------------
V
------
A
-----
P
Q
N
L
S
E
-
S
A
A
---
N
S
L
L
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
V
G
---
S
A
------------------
W
PELG--------------
F
---
T
----
S
-------
I
N
PDNTVPVYLAGY
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
-
Q
L
L
V
Y
C
V
N
--
Y
F
I
A
R
S
GD
A
S
W
L
----------------------------
N
--------------------------
T
--------------
D
--------------
G
W
R
Y
M
-
F
A
S
E
C
I
P
A
-
L
L
F
-
L
-
M
-
L
L
Y
T
V
P
E
S
P
R
W
L
M
S
R
G
K
Q
------------------------------
E
Q
---
A
---
E
---
G
I
-
L
R
----------------
K
--------------------------------
I
----------------
M
----
G
----
N
T
L
---
A
T
Q
A
V
--
Q
-
E
I
--
K
H
-
S
-
L
D
H
G
R
K
T
G
G
R
L
L
M
F
G
V
G
----
V
-
I
-----------------------
V
I
----
G
V
M
L
-
S
-
I
F
Q
Q
---
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
-----------
K
T
L
--
G
A
---
S
T
D
I
----------
A
L
---
L
Q
T
I
I
V
G
V
I
N
----------
L
T
F
T
V
L
A
I
M
T
V
D
K
-----
F
G
R
K
P
L
Q
I
I
-
G
A
L
---
G
M
A
I
G
-------
M
F
S
L
G
-------
T
--
A
-----
F
---------
Y
-----
T
---
Q
---
A
P
G
I
V
-
A
L
L
S
M
L
F
-
Y
V
-
A
-
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
-----------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
74.48
21%
-142
- C3 -
4GBY
4
XYLE_ECOLI
A:
[16-404]
-----------------------------
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
-
T
V
----
F
-----------------------
V
------
A
-----
P
Q
N
L
S
E
-
S
A
A
---
N
S
L
L
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
V
G
---
S
A
------------------
W
PELG--------------
F
---
T
----
S
-------
I
N
PDNTVPVYLAGY
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
-
Q
L
L
V
Y
C
V
N
--
Y
F
I
A
R
SGD
A
S
W
L
----------------------------
N
--------------------------
T
--------------
D
--------------
G
W
R
Y
M
-
F
A
S
E
C
I
P
A
-
L
L
F
-
L
-
M
-
L
L
Y
T
V
P
E
S
P
R
W
L
M
S
R
G
K
Q
------------------------------
E
Q
---
A
---
E
---
G
I
-
L
R
----------------
K
--------------------------------
I
----------------
M
----
G
----
N
T
L
---
A
T
Q
A
V
--
Q
-
E
I
--
K
H
-
S
-
L
D
H
G
R
K
T
G
G
R
L
L
M
F
G
V
G
----
V
-
I
-----------------------
V
I
----
G
V
M
L
-
S
-
I
F
Q
Q
---
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
-----------
K
T
L
--
G
A
---
S
T
D
I
----------
A
L
---
L
Q
T
I
I
V
G
V
I
N
----------
L
T
F
T
V
L
A
I
M
T
V
D
K
-----
F
G
R
K
P
L
Q
I
I
-
G
A
L
---
G
M
A
I
G
-------
M
F
S
L
G
-------
T
--
A
-----
F
---------
Y
-----
T
---
Q
---
A
P
G
I
V
-
A
L
L
S
M
L
F
-
Y
V
-
A
-
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
-----------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
74.23
21%
-140
- C3 -
4GBZ
4
XYLE_ECOLI
A:
[16-404]
-----------------------------
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
-
T
V
----
F
-----------------------
V
------
A
-----
P
Q
N
L
S
E
-
S
A
A
---
N
S
L
L
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
V
G
---
S
A
------------------
W
PELG--------------
F
---
T
----
S
-------
I
N
PDNTVPVYLAGY
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
-
Q
L
L
V
Y
C
V
N
--
Y
F
I
A
R
S
GD
A
S
W
L
----------------------------
N
--------------------------
T
--------------
D
--------------
G
W
R
Y
M
-
F
A
S
E
C
I
P
A
-
L
L
F
-
L
-
M
-
L
L
Y
T
V
P
E
S
P
R
W
L
M
S
R
G
K
Q
------------------------------
E
Q
---
A
---
E
---
G
I
-
L
R
----------------
K
--------------------------------
I
----------------
M
----
G
----
N
T
L
---
A
T
Q
A
V
--
Q
-
E
I
--
K
H
-
S
-
L
D
H
G
R
K
T
GGRLLMFG
V
G
----
V
-
I
-----------------------
V
I
----
G
V
M
L
-
S
-
I
F
Q
Q
---
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
-----------
K
T
L
--
G
A
---
S
T
D
I
----------
A
L
---
L
Q
T
I
I
V
G
V
I
N
----------
L
T
F
T
V
L
A
I
M
T
V
D
K
-----
F
G
R
K
P
L
Q
I
I
-
G
A
L
---
G
M
A
I
G
-------
M
F
S
L
G
-------
T
--
A
-----
F
---------
Y
-----
T
---
Q
---
A
P
G
I
V
-
A
L
L
S
M
L
F
-
Y
V
-
A
-
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
-----------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
72.32
17%
-166
- C3 -
4PYP
1
GTR1_HUMAN
A:
[10-455]
--------------------
G
R
L
M
L
A
V
G
-
G
A
V
L
G
S
L
Q
F
G
Y
N
T
G
V
I
N
A
P
Q
K
V
I
E
-
E
F
----
Y
--------
T
Q
T
W
V
H
R
YG------
E
S
I
L
P
T
T
L
-----
T
T
L
W
S
L
S
V
A
I
---
F
S
----------
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
M
M
N
L
L
A
F
V
S
A
V
L
---
M
G
------------------
F
------------------
S
KLG
K
----
S
-------
F
E
--------------
M
L
I
L
G
R
F
I
I
G
V
Y
C
G
L
T
T
G
F
V
P
M
Y
V
G
E
V
S
P
T
A
L
R
G
A
L
G
T
L
H
Q
L
G
I
V
V
G
-
I
L
I
A
Q
V
F
G
--
L
D
S
--------
I
MG--------------------------
N
--------------------------
K
--------------
D
--------------
L
W
P
L
L
-
L
S
I
I
F
I
P
A
-
L
L
Q
-
C
-
I
-
V
L
P
F
C
P
E
S
P
-------
R
F
------------------------------
L
L
---
I
NRN
E
E
--
N
R
-
A
K
----------------
S
V
L
K
K
L
R
GTADV
T
H
D
L
Q
E
M
K
E
E
S
R
Q
MMR-----
E
K---------------
K
----
V
----
T
I
L
---
E
L
F
R
S
--
P
-
A
Y
--
R
Q
P
I
-
L
I
-------------
A
V
----
V
-
L
-----------------------
Q
L
----
S
Q
Q
L
-
S
G
I
N
A
V
---
F
Y
-------
Y
S
T
S
I
F
-----------
E
K
A
--
G
V
---
Q
--
Q
----------
P
V
---
Y
A
T
I
G
S
G
I
V
N
----------
T
A
F
T
V
V
S
L
F
V
V
Q
R
-----
A
G
R
R
T
L
H
L
I
-
G
L
A
---
G
M
A
G
C
-------
A
I
L
M
T
-------
I
--
A
L
A
LLE
Q
---------
L
-----
P
W
M
S
Y
L
--
S
I
V
A
I
-
F
G
F
V
A
F
F
-
E
V
-
G
-
P
----
G
P
-
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
I
A
V
A
G
F
S
N
-----
W
T
S
----
N
-
F
I
V
G
M
C
F
Q
Y
V
E
Q
L
C
-
G
P
-
Y
V
---
F
I
-
I
F
T
V
L
L
V
L
F
F
I
F
T
Y
F
---
K
V
--
P
E
T
-------------------------------------------------------------
27
Fugue
71.79
16%
-173
- C3 -
3O7Q
1
FUCP_ECOLI
A:
[22-435]
-----------------
R
S
Y
I
I
P
F
A
L
L
C
-
S
L
F
F
L
W
A
V
A
N
N
L
N
D
I
L
L
P
Q
F
Q
Q
A
--------
F
--------
T
--------------
L
------
T
-----
N
F
Q
A
G
L
I
Q
S
A
---
F
Y
----------
F
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
K
L
S
Y
K
A
G
I
I
T
G
L
F
L
Y
A
L
G
A
A
L
F
W
P
A
A
------------------
E
------------------
I
---
M
----
N
-------
Y
T
--------------
L
F
L
V
G
L
F
I
I
A
A
G
L
G
C
L
E
T
A
A
N
P
F
V
T
V
L
G
P
E
S
S
G
H
F
R
L
N
L
A
Q
T
F
N
S
F
G
-
A
I
I
A
V
V
F
G
--
Q
S
L
--------
I
LSNVPHQS
Q
D
V
L
D
K
MS
P
E
Q
L
S
A
Y
K
H
S
L
V
L
--------------------------
S
--------------
V
--------------
Q
T
P
Y
M
-
I
I
V
A
I
V
L
L
-
V
A
L
-
L
-
I
-
M
L
T
K
F
P
A
L
Q
-------
S
D
------------------------------
N
H
---
S
---
D
---
A
K
-
Q
G
----------------
S
--------------------------------
F
----------------
S
----
A
----
S
L
S
---
R
L
A
R
I
--
R
-
H
W
--
R
W
-
A
-
V
L
-------------
A
Q
----
F
-
C
-----------------------
Y
V
----
G
A
Q
T
-
A
-
C
W
S
Y
---
L
I
-------
R
Y
A
V
E
E
-----------
I
-
P
--
G
M
---
T
A
G
F
----------
A
A
---
N
Y
L
T
G
T
M
V
C
F
----------
F
I
G
R
F
T
G
T
W
L
I
S
R
-----
F
A
P
H
K
V
L
A
A
-
Y
A
L
---
I
A
M
A
L
-------
C
L
I
S
A
-------
F
--
A
-----
G
---------
G
-----
H
---
V
---
G
L
I
A
L
-
T
L
C
S
A
F
M
-
S
I
---
Q
----
Y
P
-
T
I
F
S
L
G
I
K
N
L
G
Q
D
T
K
Y
G
S
S
F
I
V
M
T
-------
I
I
G
----
G
-
G
I
V
T
P
V
M
G
F
V
S
D
A
A
G
N
I
-------
P
-
T
A
E
L
I
P
A
L
C
F
A
V
I
F
I
---
F
A
--
R
F
R
S
Q
T
----------------------------------------------------------
21
Fugue
71.33
17%
-173
- C3 -
1PW4
-
GLPT_ECOLI
A:
[5-451]
FKPAPHKARLPAAE
I
D
P
T
Y
R
R
L
R
W
Q
I
F
L
-
G
I
F
F
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
L
V
--
E
----
Q
--------
G
--------------
F
------
S
-----
R
G
D
L
G
F
A
L
S
G
---
I
S
----------
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
S
N
P
R
V
F
L
P
A
G
L
I
L
A
A
A
V
M
L
F
---
M
G
------------------
F
------------------
V
---
P
----
W
-------
A
T
S
SIA----------
V
M
F
V
L
L
F
L
C
G
W
F
Q
G
M
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
R
G
G
I
V
S
V
W
N
C
A
H
N
V
G
G
G
I
P
P
L
L
F
L
--
L
G
M
--------
A
----------------------------
W
--------------------------
F
--------------
N
--------------
D
W
H
A
A
L
Y
M
P
A
F
C
A
I
-
L
V
A
-
L
-
F
-
A
F
A
M
M
R
D
T
P
-------
Q
S
------------------------------
C
G
---
L
---
P
---
P
I
-
E
E
----------------
Y
--------------------------------
K
----------------
N
----
D
----
T
A
K
---
Q
I
F
M
Q
--
Y
-
V
L
PN
K
L
-
L
-
W
Y
-------------
I
A
----
I
-
A
-----------------------
N
V
----
F
V
Y
L
-
L
-
R
Y
G
I
---
L
D
-------
W
S
P
T
Y
L
-----------
K
E
V
K-
H
F
---
A
L
D
K
----------
S
S
---
W
A
Y
F
L
Y
E
Y
A
G
----------
I
P
G
T
L
L
C
G
W
M
S
D
K
VFRGN
R
G
A
T
G
V
F
F
M
-
T
L
V
---
T
I
A
T
I
-------
V
Y
W
M
N
-------
P
--
A
-----
G
---------
N
-----
P
---
T
---
V
D
M
I
C
-
M
I
V
I
G
F
L
-
I
Y
-
G
-
P
----
V
M
-
L
I
G
L
H
A
L
E
L
A
P
K
K
A
A
G
T
A
A
G
F
T
G
L
F
G
-----
Y
L
G
----
G
S
V
A
A
S
A
I
V
G
Y
T
V
D
F
F
G
W
D
G
G
F
---
M
V
-
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
---
M
I
--
G
E
K
R
R
H
E
Q
L
LQELVP-------------------------------------------------
35
HHSearch
70.40
18%
-170
- C3 -
1PW4
-
GLPT_ECOLI
A:
[22-428]
-----------------
T
Y
R
R
L
R
W
Q
I
F
L
-
G
I
F
F
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
L
V
--
E
----
Q
--------
G
--------------
F
------
S
-----
R
G
D
L
G
F
A
L
S
G
---
I
S
----------
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
S
N
P
R
V
F
L
P
A
G
L
I
L
A
A
A
V
M
L
F
---
M
G
------------------
F
------------------
V
---
P
W
A
T
S
S
-------
I
A
--------------
V
M
F
V
L
L
F
L
C
G
W
F
Q
G
M
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
R
G
G
I
V
S
V
W
N
C
A
H
N
V
G
-
G
G
I
P
P
L
L
F
--
L
L
G
--------
M
----------------------------
A
W-------------------------
F
--------------
N
--------------
D
W
H
A
A
-
L
Y
M
P
A
F
C
A
-
I
L
V
A
L
-
F
-
A
F
A
M
M
R
D
T
P
-------
Q
S
------------------------------
C
G
LPP
I
---
E
---
E
Y
-
K
N
D---------------------------------------------------------------------------
T
A
K
---
Q
I
F
M
Q
--
Y
V
L
P
N-
K
L
-
L
-
W
Y
-------------
I
A
----
I
-
A
-----------------------
N
V
----
F
V
Y
L
-
L
-
R
Y
G
I
---
L
D
-------
W
S
P
T
Y
L
-----------
K
E
V
K-
H
F
---
A
L
D
K
----------
S
S
---
W
A
Y
F
L
Y
E
Y
A
G
----------
I
P
G
T
L
L
C
G
W
M
S
D
K
-----
V
F
R
G
N
R
G
A
T
-
G
V
F
F
M
T
L
V
T
I
A
-------
T
I
V
Y
W
-------
M
--
N
PA---
G
---------
N
-----
P
---
T
---
V
D
M
I
C
-
M
I
V
I
G
F
L
-
I
Y
-
G
-
P
----
V
M
-
L
I
G
L
H
A
L
E
L
A
P
K
K
A
A
G
T
A
A
G
F
T
G
L
F
G
-----
Y
L
G
----
G
S
V
A
A
S
A
I
V
G
Y
T
V
D
F
-
F
G
W
D
G
G
---
F
M
-
V
M
I
G
G
S
I
L
A
V
----------------------------------------------------------------------------
47
HHSearch
69.40
16%
-158
- C3 -
3WDO
-
?
A:
[22-377]
-----------------------------------
S
L
R
M
L
G
M
F
M
V
L
P
V
L
T
T
Y
G
M
A
L
----
Q
--------
G
--------------
A
------
S
-----
E
A
L
I
G
I
A
I
G
I
---
Y
G
----------
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
I
G
R
K
P
L
I
V
G
G
L
A
V
F
A
A
G
S
V
I
---
A
A
------------------
L
------------------
S
---
D
----
S
-------
I
W
--------------
G
I
I
L
G
R
A
L
Q
G
S
G
A
--
I
A
A
A
V
M
A
L
L
S
D
L
T
R
E
Q
N
R
T
K
A
M
A
F
I
G
V
S
F
G
I
T
-
F
A
I
A
M
V
L
G
--
P
I
I
--------
T
----------------------------
H
--------------------------
K
--------------
L
--------------
G
L
H
A
L
-
F
W
M
I
A
I
L
A
-
T
T
G
-
I
A
L
-
T
I
W
V
V
P
N
S
S
-------
T
H
------------------------------
V
L
---
N
---
R
---
E
--
S
G
----------------
M
--------------------------------
V
----------------
K
----
G
----
S
F
S
---
K
V
L
A
E
--
P
-
R
L
--
L
K
------------------
L
N
----
F
-
G
-----------------------
I
M
----
C
L
H
M
-
L
-
L
M
S
T
---
F
V
-------
A
L
P
G
Q
L
-----------
A
D
A
--
G
F
---
P
A
A
E
----------
H
W
K
V
Y
L
A
T
M
L
I
A
F
G
S
----------
V
V
P
F
I
I
Y
A
E
V
K
R
K
-----
M
K
Q
--
V
F
V
F
-
C
V
G
---
L
I
V
V
A
-------
E
I
V
L
W
N
------
A
--
Q
-----
T
---------
Q
-----
F
---
W
---
Q
L
V
V
G
-
V
Q
L
F
F
V
A
-
F
N
-
L
-
M
----
E
A
-
L
L
P
S
L
I
S
K
E
S
P
A
G
Y
K
G
T
A
M
G
V
Y
S
T
S
Q
-----
F
L
G
----
V
-
A
I
G
G
S
L
G
G
W
I
D
G
M
-
F
D
G
Q
G
V
---
F
L
-
A
G
A
M
L
---------------------------------------------------------------------------------
12
PsiBlast_PDB
69.16
21%
-158
- C3 -
4JA4
1
XYLE_ECOLI
A:
[16-410]
-----------------------------
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
-
T
V
----
F
-----------------------
V
------
A
-----
P
Q
N
L
S
E
-
S
A
A
---
N
S
L
L
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
V
G
---
S
A
------------------
W
PELG--------------
F
---
T
----
S
-------
I
N
P
D
N
T
V
PVYLAGY
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
-
Q
L
L
V
Y
C
V
N
--
Y
F
I
A
RSGD
A
S
W
L
----------------------------
N
--------------------------
T
--------------
D
--------------
G
W
R
Y
M
-
F
A
S
E
C
I
P
A
-
L
L
F
-
L
-
M
-
L
L
Y
T
V
P
E
S
P
RWLM----
Q
------------------------------
E
Q
---
A
---
E
---
G
I
-
L
R
----------------
K
--------------------------------
I
----------------
M
----
G
----
N
T
L
---
A
T
Q
A
V
--
Q
-
E
I
--
K
H
-
S
-
L
D
H
GMFG--------
V
G
----
V
-
I
-----------------------
V
I
----
G
V
M
L
-
S
-
I
F
Q
Q
---
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
-------------------------------------
L
---
L
Q
T
I
I
V
G
V
I
N
----------
L
T
F
T
V
L
A
I
M
T
V
D
K
-----
F
G
R
K
P
L
Q
I
I
-
G
A
L
---
G
M
A
I
G
-------
M
F
S
L
G
-------
T
--
A
-----
F
---------
Y
-----
T
---
Q
---
A
P
G
I
V
-
A
L
L
S
M
L
F
-
Y
V
-
A
-
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
-----------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
68.24
17%
-143
- C3 -
4ZW9
4
GTR3_HUMAN
A:
[31-448]
---------------------
A
L
I
F
A
I
T
-
V
A
T
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
-
E
F
----
I
--------
T
K
T
L
T
D
K
GNAPPS
E
V
L
------
L
-----
T
S
L
W
S
L
S
V
A
I
---
F
S
----------
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
N
L
L
A
V
T
G
G
C
F
---
M
G
------------------
L
CKV---------------
A
---
K
----
S
-------
V
E
--------------
M
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
-
I
L
V
A
Q
I
F
G
--
L
E
F
--------
I
LG--------------------------
S
--------------------------
E
--------------
E
--------------
L
W
P
L
L
-
L
G
F
T
I
L
P
A
-
I
L
Q
-
S
-
A
-
A
L
P
F
C
P
E
S
P
-------
R
F
------------------------------
L
L
---
I
---
N
---
R
K
-
E
E
----------------
E
N
A
K
Q
I
L
Q
R
L
W
GTQDV
S
Q
D
I
Q
E
M
K
D
E
S
A
R
M
S
Q
E
K
----------------
Q
----
V
----
T
V
L
---
E
L
F
R
V
--
S
-
S
Y
--
R
Q
-
P
I
I
I
-------------
S
I
----
V
-
L
-----------------------
Q
L
----
S
Q
Q
L
S
G
-
I
N
A
V
---
F
Y
-------
Y
S
T
G
I
F
-----------
K
D
A
-------
G
V
Q
E
----------
P
I
---
Y
A
T
I
G
A
G
V
V
N
----------
T
I
F
T
V
V
S
L
F
L
V
E
R
-----
A
G
R
R
T
L
H
M
I
-
G
L
G
---
G
M
A
F
C
-------
S
T
L
M
T
-------
V
--
S
-----
L
L
L
KDNY
N
G
M
S
-----
F
---
V
---
C
I
G
A
I
-
L
V
F
V
A
F
F
-
E
I
-
G
-
P
----
G
P
-
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
-----
W
T
S
----
N
-
F
L
V
G
L
L
F
P
S
A
A
H
Y
---------------------------------------------------------------------------------------------------
38
HHSearch
67.74
16%
-155
- C3 -
3O7Q
1
FUCP_ECOLI
A:
[22-420]
---------------------
R
S
Y
I
I
P
F
A
L
L
C
S
L
F
F
L
W
A
V
A
N
N
L
N
D
I
L
L
P
Q
F
Q
-
Q
A
----
F
--------
T
--------------
L
------
T
-----
N
F
Q
A
G
L
I
Q
S
A
---
F
Y
----------
F
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
K
L
S
Y
K
A
G
I
I
T
G
L
F
L
Y
A
L
G
A
A
L
---
F
W
------------------
P
------------------
A
A
E
I
M
----
N
-------
Y
T
--------------
L
F
L
V
G
L
F
I
I
A
A
G
L
G
C
L
E
T
A
A
N
P
F
V
T
V
L
G
P
E
S
S
G
H
F
R
L
N
L
A
Q
T
F
N
S
F
G
-
A
I
I
A
V
V
F
G
--
Q
S
L
--------
I
----------------------------
L
SNVPHQS
Q
D
V
L
D
K
MS
P
E
Q
L
S
A
Y
K
H
S
L
V
--------------
L
--------------
S
V
Q
T
P
-
Y
M
I
I
V
A
I
V
L
L
V
A
-
L
-
L
I
M
L
T
K
F
P
A
L
Q
-------
S
D
------------------------------
N
H
---
S
---
D
---
A
K
-
Q
G
----------------
S
--------------------------------
F
----------------
S
----
A
----
S
L
S
---
R
L
A
R
I
--
R
------
H
-
W
-
R
W
-------------
A
V
----
L
-
A
-----------------------
Q
F
----
C
Y
V
G
-
A
-
Q
T
A
C
---
W
S
-------
Y
L
I
R
Y
A
-----------
V
E
E
IP
G
M
---
T
A
G
F
----------
A
A
---
N
Y
L
T
G
T
M
V
C
F
----------
F
I
G
R
F
T
G
T
W
L
I
S
R
-----
F
A
P
H
K
V
L
A
A
-
Y
A
L
---
I
A
M
A
L
-------
C
L
I
S
A
-------
F
--
A
-----
G
---------
G
-----
H
---
V
----
G
L
I
A
-
L
T
L
C
S
A
F
-
M
S
-
I
-
Q
----
Y
P
-
T
I
F
S
L
G
I
K
N
L
G
Q
D
T
K
-
Y
G
S
S
F
I
-
V
M
T
-----
I
I
G
----
G
-
G
I
V
T
P
V
M
G
F
V
S
D
A
A
G
N
I
P
T
A
---
E
L
-
I
P
A
L
----------------------------------------------------------------------------------
39
HHSearch
67.63
17%
-174
- C3 -
4YB9
-
GTR5_BOVIN
D:
[69-462]
--------------------------------------------------------------------------------------------------
L
L
W
S
V
T
V
S
M
---
F
P
----------
F
G
G
F
L
G
S
L
M
V
G
P
L
V
N
N
L
G
R
K
G
T
L
L
F
N
N
I
F
S
I
V
P
A
L
L
---
M
G
------------------
F
------------------
S
ELA
K
----
S
-------
F
E
--------------
M
I
I
V
A
R
V
L
V
G
I
C
A
G
L
S
S
N
V
V
P
M
Y
L
G
E
L
A
P
K
N
W
R
G
A
L
G
V
V
P
Q
L
F
I
T
I
G
-
I
L
V
A
Q
I
F
G
LR
S
L
L
--------
A
----------------------------
N
--------------------------
E
--------------
E
--------------
G
W
P
I
L
-
L
G
L
T
G
I
P
A
-
V
L
Q
-
L
-
L
-
F
L
P
F
F
P
E
S
P
-------
R
Y
------------------------------
L
L
---
I
---
Q
KKD
E
A
A
A
K
----------------
S
ALRRLA--------------------------
E
IEEILEEDRAE-----
K
AVGF
I
----
S
V
L
---
K
L
F
K
M
--
R
-
S
L
--
R
W
Q
V
-
I
S
-------------
I
I
----
V
-
L
-----------------------
M
A
----
G
Q
Q
L
-
S
G
V
N
A
I
---
Y
Y
-------
Y
A
D
Q
I
Y
-----------
L
S
A
--
G
V
---
N
E
D
D
----------
V
Q
---
Y
V
T
A
G
T
G
A
V
N
----------
V
L
I
T
V
C
A
I
F
V
V
E
L
-----
M
G
R
R
F
L
L
L
L
-
G
F
S
---
V
C
F
T
A
-------
C
C
V
L
T
-------
G
AL
A
L----
Q
DV-------
I
S----
W
MP-
Y
---
V
S
I
A
C
-
V
I
S
Y
V
I
G
-
H
A
L
G
-
P
----
S
P
-
I
P
A
L
L
V
T
E
I
F
L
Q
S
S
R
P
A
A
Y
M
V
A
G
T
V
H
-----
W
L
S
----
N
-
F
T
V
G
L
V
F
P
F
I
Q
V
G
L
-
G
A
-
Y
S
---
F
V
-
I
F
A
V
I
C
L
L
T
T
V
Y
I
F
L
---
I
I
--
P
E
--------------------------------------------------------------