@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu04560: (2016-06-07 )
MYGGKSAEHNVSLQTALAVIKALNTEKFDIHPIYITEKGEWVRGARLTEPVSNVKMLQFEQGGSAFSPAALNQEMFPQEASQQNEAIDVVFPLLHGPNGEDGTIQGMLELLNIPYVGNGVLASSAGMDKVVMKHLFAQVGLAQAKYAAFLKKDWTRSPKESCEEVEQELGYPCFVKPANLGSSVGISKCRNREELQKAFELAFQYDRKVVVEEGINGREIEIGVLGNDDPKCSVVGEIAPKTDFYDYKAKYEDGDTDLMIPAIVTDEEYATISDMAIKAFKAIDGSGLVRADFFLTADGEVLINEVNTMPGFTPFSMFPLLWKEAGVEYADLIEQLVELAKERHAEKQLIKHTF
Atome Classification :
(72 SA)
.........10........20...-...-..30........40......-..-50-.....--------....-60..----...---...-.70....----..-----.-.80...----...--..90........100.......110.......120.......130....-...-140.......150..-.....160........170.......180.......190.......200.......210...-..-..220......-.-230....-...240----..----....-----..250.--..--.-..--..260.......270.......280.......290.......300.......310.......320.......330.......340.......350..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MYGGKSAEHN
V
S
L
Q
T
A
L
A
V
I
K
ALN-TE
K
-
F
D
I
H
P
I
Y
I
TEKGEWVRGARL-TE-P--VSN
V
K
--------
M
L
Q
F
-E-QG----GSA---FS
P
-
A
AL
N
Q
E
M----FP-----
Q
-
E
ASQQN----E
A
I
--
D
V
V
F
P
L
LHGPNGED
G
T
I
Q
G
M
L
E
L
LNIPYVGNGVLASSAG
M
D
K
V
V
M
K
H
L
F
-
A
QV-G
L
A
Q
A
K
Y
A
A
F
L
K
K
DW-TR
S
P
K
E
S
-
C
E
E
V
E
Q
ELGY
P
C
F
V
KPANLGSSV
G
I
S
KCR
N
R
E
E
L
Q
K
A
F
E
L
A
F
Q
YD
R
K
V
V
VEEGI-NG-
R
E
I
E
I
G
V
LGND-D-PK
C
S
V
V
G-EIAPK-----TD----FY
D
Y
-----
K
A
KY-E--DG--D-T
D
--
L
M
I
P
A
I
VTDEEYA
T
I
S
D
M
A
I
K
A
F
KAIDGS
G
L
V
R
A
D
F
F
L
TADG
E
V
L
I
N
EVNTMPGFT
P
F
S
M
F
P
L
L
W
K
EAGV
E
Y
A
D
L
I
E
Q
L
V
E
L
A
K
E
R
H
A
E
K
Q
L
I
K
HTF
21
PsiBlast_CBE
82.65
50%
-91
- C1 -
2I80
1
DDL_STAAC
B:
[9-353]
V
F
G
G
K
S
A
E
H
E
V
S
I
L
T
A
Q
N
V
L
N
A
I
D
-
K
D
K
-
Y
H
V
D
I
I
Y
I
T
N
D
G
D
W
R
K
Q
N
N
I
-
T
A
-
E
--
I
K
S
T
D
--------
E
L
H
L
-
E
--
N
----
G
E
A
---
L
E
I
-
S
Q
L
L
K
E
----------------
S
S
S
G
----
Q
P
Y
--
D
A
V
F
P
L
L
H
G
P
N
G
E
D
G
T
I
Q
G
L
F
E
V
L
D
V
P
Y
V
G
N
G
V
L
S
A
A
S
S
M
D
K
L
V
M
K
Q
L
F
-
E
H
R
-
G
L
P
Q
L
P
Y
I
S
F
L
R
S
E
Y
-
E
K
Y
E
H
N
I
-
L
K
L
V
N
D
K
L
N
Y
P
V
F
V
K
P
A
N
L
G
S
S
V
G
I
S
K
C
N
N
E
A
E
L
K
E
G
I
K
E
A
F
Q
F
D
R
K
L
V
I
E
Q
G
V
-
N
A
-
R
E
I
E
V
A
V
L
G
N
D
-
Y
-
P
E
A
T
W
P
G
-
E
V
V
K
D
-----
V
A
----
F
----------------------
V
Q
--
L
Q
I
P
A
D
L
D
E
D
V
Q
L
T
L
R
N
M
A
L
E
A
F
K
A
T
D
C
S
G
L
V
R
A
D
F
F
V
T
E
D
N
Q
I
Y
I
N
E
T
N
A
M
P
G
F
T
A
F
S
M
Y
P
K
L
W
E
N
M
G
L
S
Y
P
E
L
I
T
K
L
I
E
L
A
K
E
R
H
Q
D
K
Q
K
N
K
Y
--
22
PsiBlast_CBE
82.23
50%
-91
- C1 -
2I8C
3
DDL_STAAC
B:
[9-353]
V
F
G
G
K
S
A
E
H
E
V
S
I
L
T
A
Q
N
V
L
N
A
I
D
-
K
D
K
-
Y
H
V
D
I
I
Y
I
T
N
D
G
D
W
R
K
Q
N
N
I
-
T
A
-
E
--
I
K
S
T
D
--------
E
L
H
L
-
E
--
N
----
G
E
A
---
L
E
I
-
S
Q
L
L
K
E
----------------
S
S
S
G
----
Q
P
Y
--
D
A
V
F
P
L
L
H
G
P
N
G
E
D
G
T
I
Q
G
L
F
E
V
L
D
V
P
Y
V
G
N
G
V
L
S
A
A
S
S
M
D
K
L
V
M
K
Q
L
F
-
E
H
R
-
G
L
P
Q
L
P
Y
I
S
F
L
R
S
E
Y
-
E
K
Y
E
H
N
I
-
L
K
L
V
N
D
K
L
N
Y
P
V
F
V
K
P
A
N
L
G
S
S
V
G
I
S
K
C
N
N
E
A
E
L
K
E
G
I
K
E
A
F
Q
F
D
R
K
L
V
I
E
Q
G
V
-
N
A
-
R
E
I
E
V
A
V
L
G
N
D
-
Y
-
P
E
A
T
W
P
G
-
E
V
V
K
D
-----
V
A
----
F
----------------------
V
Q
--
L
Q
I
P
A
D
L
D
E
D
V
Q
L
T
L
R
N
M
A
L
E
A
F
K
A
T
D
C
S
G
L
V
R
A
D
F
F
V
T
E
D
N
Q
I
Y
I
N
E
T
N
A
M
P
G
F
T
A
F
S
M
Y
P
K
L
W
E
N
M
G
L
S
Y
P
E
L
I
T
K
L
I
E
L
A
K
E
R
H
Q
D
K
Q
K
N
K
Y
--
3
PsiBlast_PDB
81.51
50%
-90
- C1 -
2I8C
2
DDL_STAAC
A:
[9-353]
V
F
G
G
K
S
A
E
H
E
V
S
I
L
T
A
Q
N
V
L
N
A
I
D
-
K
D
K
-
Y
H
V
D
I
I
Y
I
T
N
D
G
D
W
R
K
Q
N
N
I
-
T
A
-
E
--
I
K
S
T
D
--------
E
L
H
L
-
E
--
N
----
G
E
A
---
L
E
I
-
S
Q
L
L
K
E
----------------
S
S
S
G
----
Q
P
Y
--
D
A
V
F
P
L
L
H
G
P
N
G
E
D
G
T
I
Q
G
L
F
E
V
L
D
V
P
Y
V
G
N
G
V
L
S
A
A
S
S
M
D
K
L
V
M
K
Q
L
F
-
E
H
R
-
G
L
P
Q
L
P
Y
I
S
F
L
R
S
E
Y
-
E
K
Y
E
H
N
I
-
L
K
L
V
N
D
K
L
N
Y
P
V
F
V
K
P
A
N
L
G
S
S
V
G
I
S
K
C
N
N
E
A
E
L
K
E
G
I
K
E
A
F
Q
F
D
R
K
L
V
I
E
Q
G
V
-
N
A
-
R
E
I
E
V
A
V
L
G
N
D
-
Y
-
P
E
A
T
W
P
G
-
E
V
V
K
D
-----
V
A
----
F
----------------------
V
Q
--
L
Q
I
P
A
D
L
D
E
D
V
Q
L
T
L
R
N
M
A
L
E
A
F
K
A
T
D
C
S
G
L
V
R
A
D
F
F
V
T
E
D
N
Q
I
Y
I
N
E
T
N
A
M
P
G
F
T
A
F
S
M
Y
P
K
L
W
E
N
M
G
L
S
Y
P
E
L
I
T
K
L
I
E
L
A
K
E
R
H
Q
D
K
Q
K
N
K
Y
--
23
PsiBlast_CBE
81.33
50%
-92
- C1 -
2I87
1
DDL_STAAC
B:
[9-353]
V
F
G
G
K
S
A
E
H
E
V
S
I
L
T
A
Q
N
V
L
N
A
I
D
-
K
D
K
-
Y
H
V
D
I
I
Y
I
T
N
D
G
D
W
R
K
Q
N
N
I
-
T
A
-
E
--
I
K
S
T
D
--------
E
L
H
L
-
E
--
N
----
G
E
----
L
E
I
-
S
Q
L
L
K
E
----------------
S
S
S
G
----
Q
P
Y
--
D
A
V
F
P
L
L
H
G
P
--
E
D
G
T
I
Q
G
L
F
E
V
L
D
V
P
Y
V
G
N
G
V
L
S
A
A
S
S
M
D
K
L
V
M
K
Q
L
F
-
E
H
R
-
G
L
P
Q
L
P
Y
I
S
F
L
R
S
E
Y
-
E
K
Y
E
H
N
I
-
L
K
L
V
N
D
K
L
N
Y
P
V
F
V
K
P
A
N
L
G
S
S
V
G
I
S
K
C
N
N
E
A
E
L
K
E
G
I
K
E
A
F
Q
F
D
R
K
L
V
I
E
Q
G
V
-
N
A
-
R
E
I
E
V
A
V
L
G
N
D
-
Y
-
P
E
A
T
W
P
G
-
E
V
V
K
D
-----
V
A
----
F
----------------------
V
Q
--
L
Q
I
P
A
D
L
D
E
D
V
Q
L
T
L
R
N
M
A
L
E
A
F
K
A
T
D
C
S
G
L
V
R
A
D
F
F
V
T
E
D
N
Q
I
Y
I
N
E
T
N
A
M
P
G
F
T
A
F
S
M
Y
P
K
L
W
E
N
M
G
L
S
Y
P
E
L
I
T
K
L
I
E
L
A
K
E
R
H
Q
D
K
Q
K
N
K
Y
--
107
HHSearch
81.02
50%
-94
- C1 -
2I87
1
DDL_STAAC
A:
[9-351]
V
F
G
G
K
S
A
E
H
E
V
S
I
L
T
A
Q
N
V
L
N
A
I
D
-
K
D
K
-
Y
H
V
D
I
I
Y
I
T
N
D
G
D
W
R
K
Q
N
N
I
-
T
A
-
E
--
I
K
S
T
D
--------
E
L
H
----
L
-----
E
-
N
---
G
E
A
-
L
E
I
S
Q
L
L
----
K
E
-----
S
-
S
---
S
G
----
Q
P
Y
--
D
A
V
F
P
L
L
H
G
P
N
G
E
D
G
T
I
Q
G
L
F
E
V
L
D
V
P
Y
V
G
N
G
V
L
S
A
A
S
S
M
D
K
L
V
M
K
Q
L
F
-
E
H
R
-
G
L
P
Q
L
P
Y
I
S
F
L
R
S
E
Y
-
E
K
Y
E
H
N
I
-
L
K
L
V
N
D
K
L
N
Y
P
V
F
V
K
P
A
N
L
G
S
S
V
G
I
S
K
C
N
N
E
A
E
L
K
E
G
I
K
E
A
F
Q
F
D
R
K
L
V
I
E
Q
G
V
-
N
A
-
R
E
I
E
V
A
V
L
G
N
D
-
Y
-
P
E
A
T
W
P
G
-
E
V
V
K
D
-----
V
A
----
F
----------------------
V
Q
--
L
Q
I
P
A
D
L
D
E
D
V
Q
L
T
L
R
N
M
A
L
E
A
F
K
A
T
D
C
S
G
L
V
R
A
D
F
F
V
T
E
D
N
Q
I
Y
I
N
E
T
N
A
M
P
G
F
T
A
F
S
M
Y
P
K
L
W
E
N
M
G
L
S
Y
P
E
L
I
T
K
L
I
E
L
A
K
E
R
H
Q
D
K
Q
K
N
----
2
PsiBlast_PDB
80.57
50%
-90
- C1 -
2I87
1
DDL_STAAC
A:
[9-353]
V
F
G
G
K
S
A
E
H
E
V
S
I
L
T
A
Q
N
V
L
N
A
I
D
-
K
D
K
-
Y
H
V
D
I
I
Y
I
T
N
D
G
D
W
R
K
Q
N
N
I
-
T
A
-
E
--
I
K
S
T
D
--------
E
L
H
L
-
E
--
N
----
G
E
A
---
L
E
I
-
S
Q
L
L
K
E
----------------
S
S
S
G
----
Q
P
Y
--
D
A
V
F
P
L
L
H
G
P
N
G
E
D
G
T
I
Q
G
L
F
E
V
L
D
V
P
Y
V
G
N
G
V
L
S
A
A
S
S
M
D
K
L
V
M
K
Q
L
F
-
E
H
R
-
G
L
P
Q
L
P
Y
I
S
F
L
R
S
E
Y
-
E
K
Y
E
H
N
I
-
L
K
L
V
N
D
K
L
N
Y
P
V
F
V
K
P
A
N
L
G
S
S
V
G
I
S
K
C
N
N
E
A
E
L
K
E
G
I
K
E
A
F
Q
F
D
R
K
L
V
I
E
Q
G
V
-
N
A
-
R
E
I
E
V
A
V
L
G
N
D
-
Y
-
P
E
A
T
W
P
G
-
E
V
V
K
D
-----
V
A
----
F
----------------------
V
Q
--
L
Q
I
P
A
D
L
D
E
D
V
Q
L
T
L
R
N
M
A
L
E
A
F
K
A
T
D
C
S
G
L
V
R
A
D
F
F
V
T
E
D
N
Q
I
Y
I
N
E
T
N
A
M
P
G
F
T
A
F
S
M
Y
P
K
L
W
E
N
M
G
L
S
Y
P
E
L
I
T
K
L
I
E
L
A
K
E
R
H
Q
D
K
Q
K
N
K
Y
--
5
PsiBlast_PDB
77.92
42%
-110
- C1 -
3K3P
-
DDL_STRMU
A:
[9-345]
L
Y
G
G
R
S
A
E
R
D
V
S
V
L
S
A
E
S
V
M
R
A
I
N
-
Y
D
N
-
F
L
V
K
T
Y
F
I
T
Q
A
G
D
F
I
K
T
Q
E
F
D
S
Q
-
P
--
S
--
D
K
--------
L
M
T
N
-
D
-
T
---------------
I
I
A
S
Q
K
I
----
K
P
-----
S
-
D
I
Y
E
E
E
----
A
-----
V
V
F
P
V
L
H
G
P
M
G
E
D
G
S
I
Q
G
F
L
E
V
L
K
M
P
Y
V
G
T
N
I
L
S
S
S
V
A
M
D
K
I
T
T
N
Q
V
L
E
S
A
T
-
T
I
P
Q
V
A
Y
V
A
L
I
E
G
E
-----
P
L
E
S
K
L
A
E
V
E
E
K
L
I
Y
P
V
F
V
K
P
A
N
------
I
S
K
A
E
N
R
T
D
L
K
Q
A
I
A
L
A
L
K
Y
D
S
R
V
L
I
E
Q
G
V
-
D
A
-
R
E
I
E
V
G
I
L
G
N
T
-
D
-
V
K
T
T
L
P
G
-
E
I
V
-------------------------------------
T
--
M
A
I
P
A
E
I
D
P
V
I
V
E
K
M
R
D
Y
A
A
T
A
F
R
T
L
G
C
C
G
L
S
R
C
D
F
F
L
T
E
D
G
K
V
Y
L
N
E
L
N
T
M
P
G
F
T
--
S
M
Y
P
L
L
W
E
N
M
G
L
S
Y
S
V
L
I
E
E
L
V
S
L
A
K
E
M
F
D
K
R
E
------
1
PsiBlast_PDB
77.24
50%
-89
- C1 -
2I80
1
DDL_STAAC
A:
[9-353]
V
F
G
G
K
S
A
E
H
E
V
S
I
L
T
A
Q
N
V
L
N
A
I
D
-
K
D
K
-
Y
H
V
D
I
I
Y
I
T
N
D
G
D
W
R
K
Q
N
N
I
-
T
A
-
E
--
I
K
S
T
D
--------
E
L
H
L
-
E
--
N
----
G
E
A
---
L
E
I
-
S
Q
L
L
K
E
----------------
S
S
S
G
----
Q
P
Y
--
D
A
V
F
P
L
L
H
G
P
N
G
E
D
G
T
I
Q
G
L
F
E
V
L
D
V
P
Y
V
G
N
G
V
L
S
A
A
S
S
M
D
K
L
V
M
K
Q
L
F
-
E
H
R
-
G
L
P
Q
L
P
Y
I
S
F
L
R
S
E
Y
-
E
K
Y
E
H
N
I
-
L
K
L
V
N
D
K
L
N
Y
P
V
F
V
K
P
A
N
L
G
S
S
V
G
I
S
K
C
N
N
E
A
E
L
K
E
G
I
K
E
A
F
Q
F
D
R
K
L
V
I
E
Q
G
V
-
N
A
-
R
E
I
E
V
A
V
L
G
N
D
-
Y
-
P
E
A
T
W
P
G
-
E
V
V
K
D
-----
V
A
----
F
----------------------
V
Q
--
L
Q
I
P
A
D
L
D
E
D
V
Q
L
T
L
R
N
M
A
L
E
A
F
K
A
T
D
C
S
G
L
V
R
A
D
F
F
V
T
E
D
N
Q
I
Y
I
N
E
T
N
A
M
P
G
F
T
A
F
S
M
Y
P
K
L
W
E
N
M
G
L
S
Y
P
E
L
I
T
K
L
I
E
L
A
K
E
R
H
Q
D
K
Q
K
N
K
Y
--
11
PsiBlast_PDB
77.11
40%
-112
- C1 -
4ME6
2
?
A:
[28-380]
I
F
G
G
K
S
A
E
H
E
V
S
L
Q
S
A
R
N
I
L
D
A
L
D
-
P
Q
R
-
F
E
P
V
L
I
G
I
D
K
Q
G
Q
W
----
H
V
-
N
D
-
P
--
D
S
F
L
L
HADDPA
R
I
A
L
H
R
-
S
-
G
R
----
G
V
A
---
L
L
P
-
G
A
Q
Q
Q
Q
L
----
R
P
-----
I
-
Q
---------
A
Q
I
--
D
V
V
F
P
I
V
H
G
T
L
G
E
D
G
S
L
Q
G
L
L
R
M
A
N
L
P
F
V
G
S
G
V
L
G
S
A
V
A
M
D
K
D
M
A
K
R
V
L
-
R
D
A
-
R
L
A
V
A
P
F
V
C
F
---
D
R
-
H
T
-
A
H
A
D
-
V
D
T
L
I
A
Q
L
G
L
P
L
F
V
K
P
A
N
Q
---
V
G
V
S
Q
V
R
T
A
D
A
F
A
A
A
L
A
L
A
L
A
Y
D
H
K
V
L
V
E
A
A
V
-
A
G
-
R
E
I
E
C
A
V
L
G
N
A
-
V
-
P
H
A
S
V
C
G
-
E
V
V
-------------------------------------
E
--
I
V
I
P
A
D
I
D
A
Q
T
Q
Q
R
I
Q
Q
I
A
V
Q
A
Y
Q
A
L
G
C
A
G
M
A
R
V
D
V
F
L
C
A
D
G
R
I
V
I
N
E
V
N
T
L
P
G
F
T
R
I
S
V
Y
P
K
L
W
Q
A
S
G
L
D
Y
R
G
L
I
T
R
L
I
E
L
A
L
E
R
H
T
D
D
Q
L
L
R
---
12
PsiBlast_PDB
76.82
38%
-103
- C1 -
4FU0
5
?
A:
[9-348]
I
F
G
G
N
S
T
E
Y
E
V
S
L
Q
S
A
S
A
V
F
E
N
I
N
-
T
N
K
-
F
D
I
I
P
I
G
I
T
R
S
G
E
W
Y
H
Y
T
G
E
-
K
E
-
K
--
I
L
N
N
T
--------
W
F
E
D
-
S
-
K
N
----------
L
C
P
-
V
V
V
S
Q
N
R
SVK
G
F
L
-----
E
-
I
----
Y
----
R
I
I
K
V
D
L
V
F
P
V
L
H
G
K
N
G
E
D
G
T
L
Q
G
I
F
E
L
A
G
I
P
V
V
G
C
D
T
L
S
S
A
L
C
M
D
K
D
R
A
H
K
L
V
-
S
L
A
-
G
I
S
V
P
K
S
V
T
F
K
R
F
N
-----
E
E
A
A
-
M
K
E
I
E
A
N
L
T
Y
P
L
F
I
K
P
V
R
A
G
S
S
F
G
I
T
K
V
I
E
K
Q
E
L
D
A
A
I
E
L
A
F
E
H
D
T
E
V
I
V
E
E
T
I
-
N
G
-
F
E
V
G
C
A
V
L
G
I
D
-
E
-
L
I
V
G
R
V
D
-
E
I
E
L
S
-----
S
G
----
F
F
D
Y
-----
T
E
K
Y
-
T
--
L
K
--
S
-
S
K
--
I
Y
M
P
A
R
I
D
A
E
A
E
K
R
I
Q
E
A
A
V
T
I
Y
K
A
L
G
C
S
G
F
S
R
V
D
M
F
Y
T
P
S
G
E
I
V
F
N
E
V
N
T
I
P
G
F
T
S
H
S
R
Y
P
N
M
M
K
G
I
G
L
S
F
S
Q
M
L
D
K
L
I
G
L
Y
V
-------------
24
PsiBlast_CBE
76.76
43%
-87
- C1 -
3I12
1
DDLA_SALTY
D:
[9-363]
V
F
G
G
K
S
A
E
H
E
V
S
L
Q
S
A
K
N
I
V
D
A
I
D
-
K
T
R
-
F
D
V
V
L
L
G
I
D
K
A
G
Q
W
-----
H
-
V
N
-
D
--
A
E
N
Y
L
--------
Q
N
A
D
-
D
-
P
A
----
H
I
A
---
L
R
P
-
S
A
I
S
L
A
Q
----
V
P
GKHQH
Q
-
L
I
N
A
Q
N
GQPL
P
T
V
--
D
V
I
F
P
I
V
H
G
T
L
G
E
D
G
S
L
Q
G
M
L
R
V
A
N
L
P
F
V
G
S
D
V
L
S
S
A
A
C
M
D
K
D
V
A
K
R
L
L
-
R
D
A
-
G
L
---
N
I
A
P
F
I
T
L
T
R
-
T
N
R
H
A
F
S
-
F
A
E
V
E
S
R
L
G
L
P
L
F
V
K
P
A
N
Q
G
S
S
V
G
V
S
K
V
A
N
E
A
Q
Y
Q
Q
A
V
A
L
A
F
E
F
D
H
K
V
V
V
E
Q
G
I
-
K
G
-
R
E
I
E
C
A
V
L
G
N
D
-
N
-
P
Q
A
S
T
C
G
-
E
I
V
L
N
-----
S
E
----
F
Y
-----------I
D
--
D
N
--
G
-
A
Q
--
V
V
V
P
A
Q
I
P
S
E
V
N
D
K
I
R
A
I
A
I
Q
A
Y
Q
T
L
G
C
A
G
M
A
R
V
D
V
F
L
T
A
D
N
E
V
V
I
N
E
I
N
T
L
P
G
F
T
N
I
S
M
Y
P
K
L
W
Q
A
S
G
L
G
Y
T
D
L
I
S
R
L
I
E
L
A
L
E
R
H
T
A
N
N
A
L
K
T
T
-
26
PsiBlast_CBE
76.21
43%
-91
- C1 -
3I12
1
DDLA_SALTY
B:
[9-363]
V
F
G
G
K
S
A
E
H
E
V
S
L
Q
S
A
K
N
I
V
D
A
I
D
-
K
T
R
-
F
D
V
V
L
L
G
I
D
K
A
G
Q
W
-----
H
-
V
N
-
D
--
A
E
N
Y
L
--------
Q
N
A
D
-
D
-
P
A
----
H
I
A
---
L
R
P
-
S
A
I
S
L
A
Q
----
V
P
GKHQH
Q
-
L
I
N
A
Q
N
GQPL
P
T
V
--
D
V
I
F
P
I
V
H
G
T
L
G
E
D
G
S
L
Q
G
M
L
R
V
A
N
L
P
F
V
G
S
D
V
L
S
S
A
A
C
M
D
K
D
V
A
K
R
L
L
-
R
D
A
-
G
L
---
N
I
A
P
F
I
T
L
T
R
-
T
N
R
H
A
F
S
-
F
A
E
V
E
S
R
L
G
L
P
L
F
V
K
P
A
N
Q
G
S
S
V
G
V
S
K
V
A
N
E
A
Q
Y
Q
Q
A
V
A
L
A
F
E
F
D
H
K
V
V
V
E
Q
G
I
-
K
G
-
R
E
I
E
C
A
V
L
G
N
D
-
N
-
P
Q
A
S
T
C
G
-
E
I
V
L
------------------------------------
Q
--
V
V
V
P
A
Q
I
P
S
E
V
N
D
K
I
R
A
I
A
I
Q
A
Y
Q
T
L
G
C
A
G
M
A
R
V
D
V
F
L
T
A
D
N
E
V
V
I
N
E
I
N
T
L
P
G
F
T
N
I
S
M
Y
P
K
L
W
Q
A
S
G
L
G
Y
T
D
L
I
S
R
L
I
E
L
A
L
E
R
H
T
A
N
N
A
L
K
T
T
-
9
PsiBlast_PDB
75.46
40%
-107
- C1 -
4L1K
2
?
A:
[26-377]
I
F
G
G
K
S
A
E
H
E
V
S
L
Q
S
A
R
N
I
L
D
A
L
D
-
P
Q
R
-
F
E
P
V
L
I
G
I
D
K
Q
G
Q
W
----
H
V
-
N
D
-
P
--
D
S
F
L
L
HADDPA
R
I
A
L
H
R
-
S
-
G
R
----
G
V
A
---
L
L
P
-
G
A
Q
Q
Q
Q
L
----
R
P
-----
I
-
Q
--
Q
A
L
----
A
Q
I
--
D
V
V
F
P
I
V
H
G
T
L
G
E
D
G
S
L
Q
G
L
L
R
M
A
N
L
P
F
V
G
S
G
V
L
G
S
A
V
A
M
D
K
D
M
A
K
R
V
L
-
R
D
A
-
R
L
A
V
A
P
F
V
C
F
---
D
R
-
H
T
A
A
H
A
D
-
V
D
T
L
I
A
Q
L
G
L
P
L
F
V
K
P
A
N
Q
G
S
S
V
G
V
S
Q
V
R
T
A
D
A
F
A
A
A
L
A
L
A
L
A
Y
D
H
K
V
L
V
E
A
A
V
-
A
G
-
R
E
I
E
C
A
V
L
G
N
A
-
V
-
P
H
A
S
V
C
G
-
E
V
V
V
------------------------------------
E
--
I
V
I
P
A
D
I
D
A
Q
T
Q
Q
R
I
Q
Q
I
A
V
Q
A
Y
Q
A
L
G
C
A
G
M
A
R
V
D
V
F
L
C
A
D
G
R
I
V
I
N
E
V
N
T
L
P
G
F
T
R
I
S
V
Y
P
K
L
W
Q
A
S
G
L
D
Y
R
G
L
I
T
R
L
I
E
L
A
L
E
R
H
T
D
D
Q
L
L
----
8
PsiBlast_PDB
75.26
40%
-106
- C1 -
3R5F
2
?
A:
[26-378]
I
F
G
G
K
S
A
E
H
E
V
S
L
Q
S
A
R
N
I
L
D
A
L
D
-
P
Q
R
-
F
E
P
V
L
I
G
I
D
K
Q
G
Q
W
----
H
V
-
N
D
-
P
--
D
S
F
L
L
HADDPA
R
I
A
L
H
R
-
S
-
G
R
----
G
V
A
---
L
L
P
-
G
A
Q
Q
Q
Q
L
----
R
P
-----
I
-
Q
---
A
L
----
A
Q
I
--
D
V
V
F
P
I
V
H
G
T
L
G
E
D
G
S
L
Q
G
L
L
R
M
A
N
L
P
F
V
G
S
G
V
L
G
S
A
V
A
M
D
K
D
M
A
K
R
V
L
-
R
D
A
-
R
L
A
V
A
P
F
V
C
F
---
D
R
-
H
T
A
A
H
A
D
-
V
D
T
L
I
A
Q
L
G
L
P
L
F
V
K
P
A
N
Q
G
S
S
V
G
V
S
Q
V
R
T
A
D
A
F
A
A
A
L
A
L
A
L
A
Y
D
H
K
V
L
V
E
A
A
V
-
A
G
-
R
E
I
E
C
A
V
L
G
N
A
-
V
-
P
H
A
S
V
C
G
-
E
V
V
V
------------------------------------
E
--
I
V
I
P
A
D
I
D
A
Q
T
Q
Q
R
I
Q
Q
I
A
V
Q
A
Y
Q
A
L
G
C
A
G
M
A
R
V
D
V
F
L
C
A
D
G
R
I
V
I
N
E
V
N
T
L
P
G
F
T
R
I
S
V
Y
P
K
L
W
Q
A
S
G
L
D
Y
R
G
L
I
T
R
L
I
E
L
A
L
E
R
H
T
D
D
Q
L
L
R
---
7
PsiBlast_PDB
75.12
40%
-109
- C1 -
3RFC
2
?
A:
[26-378]
I
F
G
G
K
S
A
E
H
E
V
S
L
Q
S
A
R
N
I
L
D
A
L
D
-
P
Q
R
-
F
E
P
V
L
I
G
I
D
K
Q
G
Q
W
----
H
V
-
N
D
-
P
--
D
S
F
L
L
HADDPA
R
I
A
L
H
R
-
S
-
G
R
----
G
V
A
---
L
L
P
-
G
A
Q
Q
Q
Q
L
----
R
P
-----
I
-
Q
--
Q
A
L
----
A
Q
I
--
D
V
V
F
P
I
V
H
G
T
L
G
E
D
G
S
L
Q
G
L
L
R
M
A
N
L
P
F
V
G
S
G
V
L
G
S
A
V
A
M
D
K
D
M
A
K
R
V
L
-
R
D
A
-
R
L
A
V
A
P
F
V
C
F
---
D
R
-
H
T
A
A
H
A
D
-
V
D
T
L
I
A
Q
L
G
L
P
L
F
V
K
P
A
N
Q
G
S
S
V
G
V
S
Q
V
R
T
A
D
A
F
A
A
A
L
A
L
A
L
A
Y
D
H
K
V
L
V
E
A
A
V
-
A
G
-
R
E
I
E
C
A
V
L
G
N
A
-
V
-
P
H
A
S
V
C
G
-
E
V
V
V
------------------------------------
E
--
I
V
I
P
A
D
I
D
A
Q
T
Q
Q
R
I
Q
Q
I
A
V
Q
A
Y
Q
A
L
G
C
A
G
M
A
R
V
D
V
F
L
C
A
D
G
R
I
V
I
N
E
V
N
T
L
P
G
F
T
R
I
S
V
Y
P
K
L
W
Q
A
S
G
L
D
Y
R
G
L
I
T
R
L
I
E
L
A
L
E
R
H
T
D
D
Q
L
L
R
---
111
HHSearch
74.66
41%
-111
- C- -
3E5N
-
?
A:
[9-359]
I
F
G
G
K
S
A
E
H
E
V
S
L
Q
S
A
R
N
I
L
D
A
L
D
-
P
Q
R
-
F
E
P
V
L
I
G
I
D
K
Q
G
Q
W
H
V
N
D
P
D
-
S
F
-
L
---
L
H
A
D
--------
D
P
A
R
I
A
-
L
H
RSGR
G
V
A
---
L
L
P
-
G
A
Q
Q
Q
Q
L
----
R
P
-----
I
-
Q
--
Q
A
L
----
A
Q
I
--
D
V
V
F
P
I
V
H
G
T
L
G
E
D
G
S
L
Q
G
L
L
R
M
A
N
L
P
F
V
G
S
G
V
L
G
S
A
V
A
M
D
K
D
M
A
K
R
V
L
-
R
D
A
-
R
L
A
V
A
P
F
V
C
F
D
R
H
T
A
-
A
H
---
A
D
-
V
D
T
L
I
A
Q
L
G
L
P
L
F
V
K
P
A
N
Q
G
S
S
V
G
V
S
Q
V
R
T
A
D
A
F
A
A
A
L
A
L
A
L
A
Y
D
H
K
V
L
V
E
A
A
V
-
A
G
-
R
E
I
E
C
A
V
L
G
N
A
-
V
-
P
H
A
S
V
C
G
-
E
V
V
V
------------------------------------
E
--
I
V
I
P
A
D
I
D
A
Q
T
Q
Q
R
I
Q
Q
I
A
V
Q
A
Y
Q
A
L
G
C
A
G
M
A
R
V
D
V
F
L
C
A
D
G
R
I
V
I
N
E
V
N
T
L
P
G
F
T
R
I
S
V
Y
P
K
L
W
Q
A
S
G
L
D
Y
R
G
L
I
T
R
L
I
E
L
A
L
E
R
H
T
D
D
Q
L
-----
10
PsiBlast_PDB
74.64
40%
-110
- C- -
3E5N
-
?
A:
[9-360]
I
F
G
G
K
S
A
E
H
E
V
S
L
Q
S
A
R
N
I
L
D
A
L
D
-
P
Q
R
-
F
E
P
V
L
I
G
I
D
K
Q
G
Q
W
----
H
V
-
N
D
-
P
--
D
S
F
L
L
HADDPA
R
I
A
L
H
R
-
S
-
G
R
----
G
V
A
---
L
L
P
-
G
A
Q
Q
Q
Q
L
----
R
P
-----
I
-
Q
--
Q
A
L
----
A
Q
I
--
D
V
V
F
P
I
V
H
G
T
L
G
E
D
G
S
L
Q
G
L
L
R
M
A
N
L
P
F
V
G
S
G
V
L
G
S
A
V
A
M
D
K
D
M
A
K
R
V
L
-
R
D
A
-
R
L
A
V
A
P
F
V
C
F
---
D
R
-
H
T
A
A
H
A
D
-
V
D
T
L
I
A
Q
L
G
L
P
L
F
V
K
P
A
N
Q
G
S
S
V
G
V
S
Q
V
R
T
A
D
A
F
A
A
A
L
A
L
A
L
A
Y
D
H
K
V
L
V
E
A
A
V
-
A
G
-
R
E
I
E
C
A
V
L
G
N
A
-
V
-
P
H
A
S
V
C
G
-
E
V
V
V
------------------------------------
E
--
I
V
I
P
A
D
I
D
A
Q
T
Q
Q
R
I
Q
Q
I
A
V
Q
A
Y
Q
A
L
G
C
A
G
M
A
R
V
D
V
F
L
C
A
D
G
R
I
V
I
N
E
V
N
T
L
P
G
F
T
R
I
S
V
Y
P
K
L
W
Q
A
S
G
L
D
Y
R
G
L
I
T
R
L
I
E
L
A
L
E
R
H
T
D
D
Q
L
L
----
4
PsiBlast_PDB
74.50
43%
-82
- C1 -
3I12
1
DDLA_SALTY
A:
[9-363]
V
F
G
G
K
S
A
E
H
E
V
S
L
Q
S
A
K
N
I
V
D
A
I
D
-
K
T
R
-
F
D
V
V
L
L
G
I
D
K
A
G
Q
W
-----
H
-
V
N
-
D
--
A
E
N
Y
L
--------
Q
N
A
D
-
D
-
P
A
----
H
I
A
---
L
R
P
-
S
A
I
S
L
A
Q
----
V
P
GKHQH
Q
-
L
I
N
A
Q
N
GQPL
P
T
V
--
D
V
I
F
P
I
V
H
G
T
L
G
E
D
G
S
L
Q
G
M
L
R
V
A
N
L
P
F
V
G
S
D
V
L
S
S
A
A
C
M
D
K
D
V
A
K
R
L
L
-
R
D
A
-
G
L
---
N
I
A
P
F
I
T
L
T
R
-
T
N
R
H
A
F
S
-
F
A
E
V
E
S
R
L
G
L
P
L
F
V
K
P
A
N
Q
G
S
S
V
G
V
S
K
V
A
N
E
A
Q
Y
Q
Q
A
V
A
L
A
F
E
F
D
H
K
V
V
V
E
Q
G
I
-
K
G
-
R
E
I
E
C
A
V
L
G
N
D
-
N
-
P
Q
A
S
T
C
G
-
E
I
V
L
N
-----
S
E
----
F
Y
-------
D
T
K
Y
I
D
--
D
N
--
G
-
A
Q
--
V
V
V
P
A
Q
I
P
S
E
V
N
D
K
I
R
A
I
A
I
Q
A
Y
Q
T
L
G
C
A
G
M
A
R
V
D
V
F
L
T
A
D
N
E
V
V
I
N
E
I
N
T
L
P
G
F
T
N
I
S
M
Y
P
K
L
W
Q
A
S
G
L
G
Y
T
D
L
I
S
R
L
I
E
L
A
L
E
R
H
T
A
N
N
A
L
K
T
T
-
6
PsiBlast_PDB
74.48
42%
-83
- C1 -
3Q1K
4
DDLA_SALTY
A:
[12-366]
V
F
G
G
K
S
A
E
H
E
V
S
L
Q
S
A
K
N
I
V
D
A
I
D
-
K
T
R
-
F
D
V
V
L
L
G
I
D
K
A
G
Q
W
-----
H
-
V
N
-
D
--
A
E
N
Y
L
--------
Q
N
A
D
-
D
-
P
A
----
H
I
A
---
L
R
P
-
S
A
I
S
L
A
Q
----
V
P
GKHQH
Q
-
L
I
N
A
Q
N
GQPL
P
T
V
--
D
V
I
F
P
I
V
H
G
T
L
G
E
D
G
S
L
Q
G
M
L
R
V
A
N
L
P
F
V
G
S
D
V
L
S
S
A
A
C
M
D
K
D
V
A
K
R
L
L
-
R
D
A
-
G
L
---
N
I
A
P
F
I
T
L
T
R
-
T
N
R
H
A
F
S
-
F
A
E
V
E
S
R
L
G
L
P
L
F
V
K
P
A
N
Q
G
S
S
V
G
V
S
K
V
A
N
E
A
Q
Y
Q
Q
A
V
A
L
A
F
E
F
D
H
K
V
V
V
E
Q
G
I
-
K
G
-
R
E
I
E
C
A
V
L
G
N
D
-
N
-
P
Q
A
S
T
C
G
-
E
I
V
L
N
-----
S
E
----
F
----------
K
Y
I
D
--
D
N
--
G
-
A
Q
--
V
V
V
P
A
Q
I
P
S
E
V
N
D
K
I
R
A
I
A
I
Q
A
Y
Q
T
L
G
C
A
G
M
A
R
V
D
V
F
L
T
A
D
N
E
V
V
I
N
E
I
N
T
L
P
G
F
T
N
I
S
M
Y
P
K
L
W
Q
A
S
G
L
G
Y
T
D
L
I
S
R
L
I
E
L
A
L
E
R
H
T
A
N
N
A
L
K
T
T
-
108
HHSearch
74.44
44%
-104
- C1 -
3K3P
-
DDL_STRMU
A:
[9-346]
L
Y
G
G
R
S
A
E
R
D
V
S
V
L
S
A
E
S
V
M
R
A
I
N
-
Y
D
N
-
F
L
V
K
T
Y
F
I
T
Q
A
G
D
F
I
K
T
Q
E
F
-
D
S
--------
Q
--------
P
S
---
D
-
K
L
----
M
T
----
N
D
T
-
I
I
A
S
Q
K
I
----
K
P
-----
S
----
D
I
Y
----
E
E
E
--
A
V
V
F
P
V
L
H
G
P
M
G
E
D
G
S
I
Q
G
F
L
E
V
L
K
M
P
Y
V
G
T
N
I
L
S
S
S
V
A
M
D
K
I
T
T
N
Q
V
L
-
E
S
A
T
T
I
P
Q
V
A
Y
V
A
L
I
E
G
E
P
-
L
E
S
---
K
-
L
A
E
V
E
E
K
L
I
Y
P
V
F
V
K
P
A
N
------
I
S
K
A
E
N
R
T
D
L
K
Q
A
I
A
L
A
L
K
Y
D
S
R
V
L
I
E
Q
G
V
-
D
A
-
R
E
I
E
V
G
I
L
G
N
T
-
D
-
V
K
T
T
L
P
G
-
E
I
V
-------------------------------------
T
--
M
A
I
P
A
E
I
D
P
V
I
V
E
K
M
R
D
Y
A
A
T
A
F
R
T
L
G
C
C
G
L
S
R
C
D
F
F
L
T
E
D
G
K
V
Y
L
N
E
L
N
T
M
P
G
F
T
--
S
M
Y
P
L
L
W
E
N
M
G
L
S
Y
S
V
L
I
E
E
L
V
S
L
A
K
E
M
F
D
K
R
E
S
-----
109
HHSearch
73.90
38%
-100
- C1 -
4FU0
5
?
A:
[9-348]
I
F
G
G
N
S
T
E
Y
E
V
S
L
Q
S
A
S
A
V
F
E
N
I
N
-
T
N
K
-
F
D
I
I
P
I
G
I
T
R
S
G
E
W
Y
H
Y
T
G
E
-
K
E
K
I
L
N
N
T
W
F
E
--------
D
S
K
N
-
L
-
C
P
----
V
V
V
S
QN
R
S
V
-
K
G
F
L
E
I
--------------
Y
---
R
I
----
I
K
V
--
D
L
V
F
P
V
L
H
G
K
N
G
E
D
G
T
L
Q
G
I
F
E
L
A
G
I
P
V
V
G
C
D
T
L
S
S
A
L
C
M
D
K
D
R
A
H
K
L
V
-
S
L
A
-
G
I
S
V
P
K
S
V
T
F
K
R
F
N
E
-
E
A
A
-----
M
K
E
I
E
A
N
L
T
Y
P
L
F
I
K
P
V
R
A
G
S
S
F
G
I
T
K
V
I
E
K
Q
E
L
D
A
A
I
E
L
A
F
E
H
D
T
E
V
I
V
E
E
T
I
-
N
G
-
F
E
V
G
C
A
V
L
G
I
D
-
E
-
L
I
V
G
R
V
D
-
E
I
E
L
S
-----
S
G
----
F
F
D
Y
-----
T
E
K
Y
-
T
--
L
K
--
S
-
S
K
--
I
Y
M
P
A
R
I
D
A
E
A
E
K
R
I
Q
E
A
A
V
T
I
Y
K
A
L
G
C
S
G
F
S
R
V
D
M
F
Y
T
P
S
G
E
I
V
F
N
E
V
N
T
I
P
G
F
T
S
H
S
R
Y
P
N
M
M
K
G
I
G
L
S
F
S
Q
M
L
D
K
L
I
G
L
Y
V
-------------
27
PsiBlast_CBE
73.39
38%
-109
- C1 -
4FU0
6
?
B:
[9-348]
I
F
G
G
N
S
T
E
Y
E
V
S
L
Q
S
A
S
A
V
F
E
N
I
N
-
T
N
K
-
F
D
I
I
P
I
G
I
T
R
S
G
E
W
Y
H
Y
T
G
E
-
K
E
-
K
--
I
L
N
N
T
--------
W
F
E
D
-
S
-
K
N
----------
L
C
P
-
V
V
V
S
Q
N
R
SVKG
F
L
-----
E
-
I
----
Y
----
R
I
I
KV
D
L
V
F
P
V
L
H
G
K
N
G
E
D
G
T
L
Q
G
I
F
E
L
A
G
I
P
V
V
G
C
D
T
L
S
S
A
L
C
M
D
K
D
R
A
H
K
L
V
-
S
L
A
-
G
I
S
V
P
K
S
V
T
F
K
R
F
N
-----
E
E
A
A
-
M
K
E
I
E
A
N
L
T
Y
P
L
F
I
K
P
V
R
A
G
S
S
F
G
I
T
K
V
I
E
K
Q
E
L
D
A
A
I
E
L
A
F
E
H
D
T
E
V
I
V
E
E
T
I
-
N
G
-
F
E
V
G
C
A
V
L
G
I
D
-
E
-
L
I
V
G
R
V
D
-
E
I
E
L
S
-----
S
G
----
F
F
D
Y
-----
T
E
K
Y
-
T
--
L
K
--
S
-
S
K
--
I
Y
M
P
A
R
I
D
A
E
A
E
K
R
I
Q
E
A
A
V
T
I
Y
K
A
L
G
C
S
G
F
S
R
V
D
M
F
Y
T
P
S
G
E
I
V
F
N
E
V
N
T
I
P
G
F
T
S
H
S
R
Y
P
N
M
M
K
G
I
G
L
S
F
S
Q
M
L
D
K
L
I
G
L
Y
V
-------------
68
PsiBlast_CBE
71.97
35%
-102
- C1 -
5BPH
5
?
C:
[8-305]
L
L
G
G
T
S
A
E
R
E
V
S
L
L
S
G
Q
A
V
L
A
G
L
K
-
E
A
G
-
I
D
A
Y
G
V
D
T
K
D
F
-------------
P
--
V
T
Q
L
K
-------------
E
-
Q
G
----------------------------------------------
F
--
D
K
V
F
I
A
L
H
G
R
G
G
E
D
G
T
L
Q
G
V
L
E
F
L
Q
L
P
Y
T
G
S
G
V
M
A
S
A
L
T
M
D
K
L
R
T
K
L
V
W
-
Q
A
L
-
G
L
P
I
S
P
Y
V
A
L
N
R
Q
Q
F
E
T
L
S
P
E
E
L
-
V
A
C
V
A
K
-
L
G
L
P
L
I
V
K
P
S
H
E
G
S
S
V
G
M
S
K
V
D
H
A
S
E
L
Q
K
A
L
V
E
A
F
Q
H
D
S
D
V
L
I
E
K
W
L
-
S
G
-
P
E
F
T
V
A
I
L
G
-
D
-
E
-
V
L
P
S
I
---
R
I
Q
P
P
-----
G
V
----
F
Y
D
Y
-----
D
A
K
Y
-
L
--
S
D
--
K
-
T
Q
--
Y
F
C
P
S
G
L
S
D
E
S
E
Q
Q
L
A
A
L
A
L
Q
A
Y
H
A
L
D
C
S
G
W
G
R
V
D
V
M
Q
D
R
D
G
H
F
Y
L
L
E
V
N
T
S
P
G
M
T
S
H
S
L
V
P
M
A
A
R
Q
Y
G
L
S
F
S
Q
L
V
A
R
I
L
M
L
A
--------------
69
PsiBlast_CBE
71.17
35%
-106
- C1 -
5BPH
6
?
B:
[8-305]
L
L
G
G
T
S
A
E
R
E
V
S
L
L
S
G
Q
A
V
L
A
G
L
K
-
E
A
G
-
I
D
A
Y
G
V
D
T
K
D
F
-------------
P
--
V
T
Q
L
K
-------------
E
-
Q
G
----------------------------------------------
F
--
D
K
V
F
I
A
L
H
G
R
G
G
E
D
G
T
L
Q
G
V
L
E
F
L
Q
L
P
Y
T
G
S
G
V
M
A
S
A
L
T
M
D
K
L
R
T
K
L
V
W
-
Q
A
L
-
G
L
P
I
S
P
Y
V
A
L
N
R
Q
Q
F
E
T
L
S
P
E
E
L
-
V
A
C
V
A
K
-
L
G
L
P
L
I
V
K
P
S
H
E
G
S
S
V
G
M
S
K
V
D
H
A
S
E
L
Q
K
A
L
V
E
A
F
Q
H
D
S
D
V
L
I
E
K
W
L
-
S
G
-
P
E
F
T
V
A
I
L
G
-
D
-
E
-
V
L
P
S
I
---
R
I
Q
P
P
-----
G
V
----
F
Y
D
Y
-----
D
A
K
Y
-
L
--
S
D
--
K
-
T
Q
--
Y
F
C
P
S
G
L
S
D
E
S
E
Q
Q
L
A
A
L
A
L
Q
A
Y
H
A
L
D
C
S
G
W
G
R
V
D
V
M
Q
D
R
D
G
H
F
Y
L
L
E
V
N
T
S
P
G
M
T
S
H
S
L
V
P
M
A
A
R
Q
Y
G
L
S
F
S
Q
L
V
A
R
I
L
M
L
A
--------------
73
PsiBlast_CBE
70.92
35%
-110
- C1 -
5BPF
4
?
B:
[8-305]
L
L
G
G
T
S
A
E
R
E
V
S
L
L
S
G
Q
A
V
L
A
G
L
K
-
E
A
G
-
I
D
A
Y
G
V
D
T
K
D
F
-------------
P
--
V
T
Q
L
K
-------------
E
-
Q
G
----------------------------------------------
F
--
D
K
V
F
I
A
L
H
G
R
G
G
E
D
G
T
L
Q
G
V
L
E
F
L
Q
L
P
Y
T
G
S
G
V
M
A
S
A
L
T
M
D
K
L
R
T
K
L
V
W
-
Q
A
L
-
G
L
P
I
S
P
Y
V
A
L
N
R
Q
Q
F
E
T
L
S
P
E
E
L
-
V
A
C
V
A
K
-
L
G
L
P
L
I
V
K
P
S
H
---
S
V
G
M
S
K
V
D
H
A
S
E
L
Q
K
A
L
V
E
A
F
Q
-
D
S
D
V
L
I
E
K
W
L
-
S
G
-
P
E
F
T
V
A
I
L
G
-
D
-
E
-
V
L
P
S
I
---
R
I
Q
P
P
-----
G
V
----
F
Y
D
Y
-----
D
A
K
--
L
--
S
D
--
K
-
T
Q
--
Y
F
C
P
S
G
L
S
D
E
S
E
Q
Q
L
A
A
L
A
L
Q
A
Y
H
A
L
D
C
S
G
W
G
R
V
D
V
M
Q
D
R
D
G
H
F
Y
L
L
E
V
N
T
S
P
G
M
T
S
H
S
L
V
P
M
A
A
R
Q
Y
G
L
S
F
S
Q
L
V
A
R
I
L
M
L
A
--------------
64
PsiBlast_CBE
70.75
35%
-106
- C1 -
5C1O
4
?
C:
[8-305]
L
L
G
G
T
S
A
E
R
E
V
S
L
L
S
G
Q
A
V
L
A
G
L
K
-
E
A
G
-
I
D
A
Y
G
V
D
T
K
D
F
-------------
P
--
V
T
Q
L
K
-------------
E
-
Q
G
----------------------------------------------
F
--
D
K
V
F
I
A
L
H
G
R
G
G
E
D
G
T
L
Q
G
V
L
E
F
L
Q
L
P
Y
T
G
S
G
V
M
A
S
A
L
T
M
D
K
L
R
T
K
L
V
W
-
Q
A
L
-
G
L
P
I
S
P
Y
V
A
L
N
R
Q
Q
F
E
T
L
S
P
E
E
L
-
V
A
C
V
A
K
-
L
G
L
P
L
I
V
K
P
S
H
E
G
S
S
V
G
M
S
K
V
D
H
A
S
E
L
Q
K
A
L
V
E
A
F
Q
H
D
S
D
V
L
I
E
K
W
L
-
S
G
-
P
E
F
T
V
A
I
L
G
-
D
-
E
-
V
L
P
S
I
---
R
I
Q
P
P
-----
G
V
----
F
Y
D
Y
-----
D
A
K
Y
-
L
--
S
D
--
K
-
T
Q
--
Y
F
C
P
S
G
L
S
D
E
S
E
Q
Q
L
A
A
L
A
L
Q
A
Y
H
A
L
D
C
S
G
W
G
R
V
D
V
M
Q
D
R
D
G
H
F
Y
L
L
E
V
N
T
S
P
G
M
T
S
H
S
L
V
P
M
A
A
R
Q
Y
G
L
S
F
S
Q
L
V
A
R
I
L
M
L
A
--------------
60
PsiBlast_CBE
70.43
35%
-105
- C1 -
5C1P
8
?
C:
[8-305]
L
L
G
G
T
S
A
E
R
E
V
S
L
L
S
G
Q
A
V
L
A
G
L
K
-
E
A
G
-
I
D
A
Y
G
V
D
T
K
D
F
-------------
P
--
V
T
Q
L
K
-------------
E
-
Q
G
----------------------------------------------
F
--
D
K
V
F
I
A
L
H
G
R
G
G
E
D
G
T
L
Q
G
V
L
E
F
L
Q
L
P
Y
T
G
S
G
V
M
A
S
A
L
T
M
D
K
L
R
T
K
L
V
W
-
Q
A
L
-
G
L
P
I
S
P
Y
V
A
L
N
R
Q
Q
F
E
T
L
S
P
E
E
L
-
V
A
C
V
A
K
-
L
G
L
P
L
I
V
K
P
S
H
E
G
S
S
V
G
M
S
K
V
D
H
A
S
E
L
Q
K
A
L
V
E
A
F
Q
H
D
S
D
V
L
I
E
K
W
L
-
S
G
-
P
E
F
T
V
A
I
L
G
-
D
-
E
-
V
L
P
S
I
---
R
I
Q
P
P
-----
G
V
----
F
Y
D
Y
-----
D
A
K
Y
-
L
--
S
D
--
K
-
T
Q
--
Y
F
C
P
S
G
L
S
D
E
S
E
Q
Q
L
A
A
L
A
L
Q
A
Y
H
A
L
D
C
S
G
W
G
R
V
D
V
M
Q
D
R
D
G
H
F
Y
L
L
E
V
N
T
S
P
G
M
T
S
H
S
L
V
P
M
A
A
R
Q
Y
G
L
S
F
S
Q
L
V
A
R
I
L
M
L
A
--------------
70
PsiBlast_CBE
70.11
35%
-103
- C1 -
5BPH
6
?
A:
[8-305]
L
L
G
G
T
S
A
E
R
E
V
S
L
L
S
G
Q
A
V
L
A
G
L
K
-
E
A
G
-
I
D
A
Y
G
V
D
T
K
D
F
-------------
P
--
V
T
Q
L
K
-------------
E
-
Q
G
----------------------------------------------
F
--
D
K
V
F
I
A
L
H
G
R
G
G
E
D
G
T
L
Q
G
V
L
E
F
L
Q
L
P
Y
T
G
S
G
V
M
A
S
A
L
T
M
D
K
L
R
T
K
L
V
W
-
Q
A
L
-
G
L
P
I
S
P
Y
V
A
L
N
R
Q
Q
F
E
T
L
S
P
E
E
L
-
V
A
C
V
A
K
-
L
G
L
P
L
I
V
K
P
S
H
E
G
S
S
V
G
M
S
K
V
D
H
A
S
E
L
Q
K
A
L
V
E
A
F
Q
H
D
S
D
V
L
I
E
K
W
L
-
S
G
-
P
E
F
T
V
A
I
L
G
-
D
-
E
-
V
L
P
S
I
---
R
I
Q
P
P
-----
G
V
----
F
Y
D
Y
-----
D
A
K
Y
-
L
--
S
D
--
K
-
T
Q
--
Y
F
C
P
S
G
L
S
D
E
S
E
Q
Q
L
A
A
L
A
L
Q
A
Y
H
A
L
D
C
S
G
W
G
R
V
D
V
M
Q
D
R
D
G
H
F
Y
L
L
E
V
N
T
S
P
G
M
T
S
H
S
L
V
P
M
A
A
R
Q
Y
G
L
S
F
S
Q
L
V
A
R
I
L
M
L
A
--------------
72
PsiBlast_CBE
70.10
35%
-104
- C1 -
5BPF
5
?
C:
[8-305]
L
L
G
G
T
S
A
E
R
E
V
S
L
L
S
G
Q
A
V
L
A
G
L
K
-
E
A
G
-
I
D
A
Y
G
V
D
T
K
D
F
-------------
P
--
V
T
Q
L
K
-------------
E
-
Q
G
----------------------------------------------
F
--
D
K
V
F
I
A
L
H
G
R
G
G
E
D
G
T
L
Q
G
V
L
E
F
L
Q
L
P
Y
T
G
S
G
V
M
A
S
A
L
T
M
D
K
L
R
T
K
L
V
W
-
Q
A
L
-
G
L
P
I
S
P
Y
V
A
L
N
R
Q
Q
F
E
T
L
S
P
E
E
L
-
V
A
C
V
A
K
-
L
G
L
P
L
I
V
K
P
S
H
E
G
S
S
V
G
M
S
K
V
D
H
A
S
E
L
Q
K
A
L
V
E
A
F
Q
H
D
S
D
V
L
I
E
K
W
L
-
S
G
-
P
E
F
T
V
A
I
L
G
-
D
-
E
-
V
L
P
S
I
---
R
I
Q
P
P
-----
G
V
----
F
Y
D
Y
-----
D
A
K
Y
-
L
--
S
D
--
K
-
T
Q
--
Y
F
C
P
S
G
L
S
D
E
S
E
Q
Q
L
A
A
L
A
L
Q
A
Y
H
A
L
D
C
S
G
W
G
R
V
D
V
M
Q
D
R
D
G
H
F
Y
L
L
E
V
N
T
S
P
G
M
T
S
H
S
L
V
P
M
A
A
R
Q
Y
G
L
S
F
S
Q
L
V
A
R
I
L
M
L
A
--------------