@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu06430: (2016-06-10 )
MSKQIIYPGAVIGIIGGGQLGKMMAVSAKQMGYKVAVVDPVKDSPCGQVADVEITAHYNDREAIRKLAEISDIITYEFENIDYDALHWLKDHAYLPQGSELLLITQNRETEKKAIQSAGCEVAPYSIVKTKNELKQAVQELRLPAVLKTCRGGYDGKGQFVIKEEAQMEQAAALLEHGTCILESWVSFKMELSVIVVRSVNGEISTFPTAENIHHNNILFQSIVPARVEKGIQQKAADLAVKLADELNLVGPLAVEMFLTEDGELLVNELAPRPHNSGHYTLDLCETSQFEQHIRAVCGLPLGKTDLLKPGMMVNLLGDEVKLVEEDPELLKEAKLYIYGKHEIKKGRKMGHITFMKQPEDEWIQEITNKWMNRDGGQAE
Atome Classification :
(31 SA)
.........10........20........30........40.......-----.--50........60........70........80.....-...90--....-....100.......110.......120......--.130...---....140---.......150..-......160.......170...--....--180.......-190.......200.........210.......220.....-..-230.-......240.......250.......260.......270.......280.......290.......300...-.-.--..310.....-..----------320-..----......330..--.......340..-.....350...-....360.......370.......380
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSK
Q
I
IYPG
A
V
I
G
I
IGGGQL
G
K
M
M
A
V
S
A
K
QMG
Y
K
V
A
V
VDPVKDSPCG
Q
-----
V
--
A
D
V
E
I
T
A
HYN
D
R
E
A
I
R
K
L
A
E
I
S
D
I
I
T
Y
E
FENI
D
Y
D
A
L
-
H
W
L
K
D--HAYL-PQG
S
E
L
L
L
I
TQNR
E
T
E
K
K
A
I
Q
SAGCEVA
P
Y
S
I
V--K
T
K
N
E
L
K
---
Q
A
V
Q
ELR---
L
P
A
V
L
K
T
C
-RGG-YDGK
G
Q
F
V
I
K
E
E
A
Q
M
E
Q
A
A
A
L
L
--EH
G
T
--
C
I
L
E
S
W
V
S
F
K
-
M
E
L
S
V
I
V
V
R
SV--NGEISTFPTAENIHHN
N
I
L
F
Q
S
I
V
P
A
R
-
V
E
-
K
G
I
Q
-
Q
K
A
A
D
L
A
V
K
L
A
D
E
LNLV
G
P
L
A
V
E
M
F
LTED
G
E
L
L
V
N
E
LAPRPHNSG
H
Y
T
L
D
LC
E
T
S
Q
F
E
Q
H
I
R
A
V
CGLPLG
K
T
-D-L--LKPG
M
M
V
N
LL-GD----------E
V
--
K
L----VEE
D
P
E
L
--
L
K
--EA
K
L
Y
I
Y
G
K
H
E
I
-KKGRKMG
H
I
T
F
-MKQP
E
D
E
W
I
Q
E
I
T
N
K
W
MNRDGGQAE
83
HHSearch
79.91
59%
-104
- C2 -
3Q2O
1
?
A:
[10-381]
----
I
I
L
P
G
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
C
A
Q
-----
V
--
A
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
-
Q
W
L
E
K
--
H
A
Y
L
-
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
--
Q
N
Q
E
Q
L
T
---
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
-
G
G
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
--
N
A
A
E
--
C
I
L
E
K
W
V
P
F
E
-
K
E
V
S
V
I
V
I
R
S
V
--
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
E
S
I
V
P
A
R
-
I
T
-
E
E
L
S
-
Q
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
E
T
-
N
-
L
--
L
K
P
V
V
M
V
N
I
L
G
E
H
I
---------
E
G
--
V
L
----
R
-
Q
V
N
R
---
L
T
--
G
C
Y
L
H
L
Y
G
K
E
E
A
-
K
A
Q
R
K
M
G
H
V
N
I
-
L
N
D
N
I
E
V
A
L
E
K
A
K
S
L
H
I
W
D
H
Q
----
1
PsiBlast_PDB
79.61
61%
-111
- C2 -
4DLK
7
?
A:
[3-355]
---
R
I
I
L
P
G
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
C
A
Q
-----
V
--
A
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
-
Q
W
L
E
K
--
H
A
Y
L
-
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
--
Q
N
Q
E
Q
L
T
---
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
-
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
--
N
A
A
E
--
C
I
L
E
K
W
V
P
F
E
-
K
E
V
S
V
I
V
I
R
S
V
--
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
E
S
I
V
P
A
R
-
I
T
-
E
E
L
S
-
Q
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
E
T
-
N
-
L
--
L
K
P
V
V
M
V
N
I
L
-
G
E
----------
H
I
--
E
G
----
V
L
R
Q
V
N
R
--
L
T
--
G
C
Y
L
H
L
Y
G
K
E
E
A
-
K
A
Q
R
K
M
G
H
V
N
I
-
L
------------------------
3
PsiBlast_PDB
79.44
61%
-111
- C2 -
3QFF
1
?
A:
[9-361]
---
R
I
I
L
P
G
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
C
A
Q
-----
V
--
A
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
-
Q
W
L
E
K
--
H
A
Y
L
-
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
--
Q
N
Q
E
Q
L
T
---
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
-
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
--
N
A
A
E
--
C
I
L
E
K
W
V
P
F
E
-
K
E
V
S
V
I
V
I
R
S
V
--
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
E
S
I
V
P
A
R
-
I
T
-
E
E
L
S
-
Q
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
E
T
-
N
-
L
--
L
K
P
V
V
M
V
N
I
L
-
G
E
----------
H
I
--
E
G
----
V
L
R
Q
V
N
R
--
L
T
--
G
C
Y
L
H
L
Y
G
K
E
E
A
-
K
A
Q
R
K
M
G
H
V
N
I
-
L
------------------------
4
PsiBlast_PDB
79.20
61%
-108
- C2 -
3R5H
3
?
A:
[9-361]
---
R
I
I
L
P
G
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
C
A
Q
-----
V
--
A
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
-
Q
W
L
E
K
--
H
A
Y
L
-
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
--
Q
N
Q
E
Q
L
T
---
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
-
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
--
N
A
A
E
--
C
I
L
E
K
W
V
P
F
E
-
K
E
V
S
V
I
V
I
R
S
V
--
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
E
S
I
V
P
A
R
-
I
T
-
E
E
L
S
-
Q
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
E
T
-
N
-
L
--
L
K
P
V
V
M
V
N
I
L
-
G
E
----------
H
I
--
E
G
----
V
L
R
Q
V
N
R
--
L
T
--
G
C
Y
L
H
L
Y
G
K
E
E
A
-
K
A
Q
R
K
M
G
H
V
N
I
-
L
------------------------
23
PsiBlast_CBE
79.12
61%
-109
- C2 -
3QFF
1
?
B:
[9-361]
---
R
I
I
L
P
G
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
C
A
Q
-----
V
--
A
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
-
Q
W
L
E
K
--
H
A
Y
L
-
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
--
Q
N
Q
E
Q
L
T
---
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
-
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
--
N
A
A
E
--
C
I
L
E
K
W
V
P
F
E
-
K
E
V
S
V
I
V
I
R
S
V
--
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
E
S
I
V
P
A
R
-
I
T
-
E
E
L
S
-
Q
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
E
T
-
N
-
L
--
L
K
P
V
V
M
V
N
I
L
-
G
E
----------
H
I
--
E
G
----
V
L
R
Q
V
N
R
--
L
T
--
G
C
Y
L
H
L
Y
G
K
E
E
A
-
K
A
Q
R
K
M
G
H
V
N
I
-
L
------------------------
24
PsiBlast_CBE
79.00
61%
-107
- C2 -
3Q2O
1
?
B:
[9-361]
---
R
I
I
L
P
G
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
C
A
Q
-----
V
--
A
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
-
Q
W
L
E
K
--
H
A
Y
L
-
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
--
Q
N
Q
E
Q
L
T
---
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
-
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
--
N
A
A
E
--
C
I
L
E
K
W
V
P
F
E
-
K
E
V
S
V
I
V
I
R
S
V
--
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
E
S
I
V
P
A
R
-
I
T
-
E
E
L
S
-
Q
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
E
T
-
N
-
L
--
L
K
P
V
V
M
V
N
I
L
-
G
E
----------
H
I
--
E
G
----
V
L
R
Q
V
N
R
--
L
T
--
G
C
Y
L
H
L
Y
G
K
E
E
A
-
K
A
Q
R
K
M
G
H
V
N
I
-
L
------------------------
2
PsiBlast_PDB
78.95
61%
-107
- C2 -
3Q2O
1
?
A:
[9-361]
---
R
I
I
L
P
G
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
C
A
Q
-----
V
--
A
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
-
Q
W
L
E
K
--
H
A
Y
L
-
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
--
Q
N
Q
E
Q
L
T
---
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
-
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
--
N
A
A
E
--
C
I
L
E
K
W
V
P
F
E
-
K
E
V
S
V
I
V
I
R
S
V
--
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
E
S
I
V
P
A
R
-
I
T
-
E
E
L
S
-
Q
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
E
T
-
N
-
L
--
L
K
P
V
V
M
V
N
I
L
-
G
E
----------
H
I
--
E
G
----
V
L
R
Q
V
N
R
--
L
T
--
G
C
Y
L
H
L
Y
G
K
E
E
A
-
K
A
Q
R
K
M
G
H
V
N
I
-
L
------------------------
21
PsiBlast_CBE
78.32
61%
-106
- C2 -
4DLK
4
?
B:
[3-355]
---
R
I
I
L
P
G
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
C
A
Q
-----
V
--
A
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
-
Q
W
L
E
K
--
H
A
Y
L
-
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
--
Q
N
Q
E
Q
L
T
---
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
-
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
--
N
A
A
E
--
C
I
L
E
K
W
V
P
F
E
-
K
E
V
S
V
I
V
I
R
S
V
--
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
E
S
I
V
P
A
R
-
I
T
-
E
E
L
S
-
Q
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
E
T
-
N
-
L
--
L
K
P
V
V
M
V
N
I
L
-
G
E
----------
H
I
--
E
G
----
V
L
R
Q
V
N
R
--
L
T
--
G
C
Y
L
H
L
Y
G
K
E
E
A
-
K
A
Q
R
K
M
G
H
V
N
I
-
L
------------------------
5
PsiBlast_PDB
78.05
61%
-105
- C2 -
3V4S
3
?
A:
[9-361]
---
R
I
I
L
P
G
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
C
A
Q
-----
V
--
A
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
-
Q
W
L
E
K
--
H
A
Y
L
-
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
--
Q
N
Q
E
Q
L
T
---
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
-
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
--
N
A
A
E
--
C
I
L
E
K
W
V
P
F
E
-
K
E
V
S
V
I
V
I
R
S
V
--
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
E
S
I
V
P
A
R
-
I
T
-
E
E
L
S
-
Q
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
E
T
-
N
-
L
--
L
K
P
V
V
M
V
N
I
L
-
G
E
----------
H
I
--
E
G
----
V
L
R
Q
V
N
R
--
L
T
--
G
C
Y
L
H
L
Y
G
K
E
E
A
-
K
A
Q
R
K
M
G
H
V
N
I
-
L
------------------------
22
PsiBlast_CBE
77.23
61%
-106
- C2 -
3R5H
3
?
B:
[9-361]
---
R
I
I
L
P
G
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
C
A
Q
-----
V
--
A
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
-
Q
W
L
E
K
--
H
A
Y
L
-
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
--
Q
N
Q
E
Q
L
T
---
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
-
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
--
N
A
A
E
--
C
I
L
E
K
W
V
P
F
E
-
K
E
V
S
V
I
V
I
R
S
V
--
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
E
S
I
V
P
A
R
-
I
T
-
E
E
L
S
-
Q
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
E
T
-
N
-
L
--
L
K
P
V
V
M
V
N
I
L
-
G
E
----------
H
I
--
E
G
----
V
L
R
Q
V
N
R
--
L
T
--
G
C
Y
L
H
L
Y
G
K
E
E
A
-
K
A
Q
R
K
M
G
H
V
N
I
-
L
------------------------
25
PsiBlast_CBE
77.18
61%
-108
- C2 -
3V4S
4
?
B:
[9-361]
---
R
I
I
L
P
G
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
C
A
Q
-----
V
--
A
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
-
Q
W
L
E
K
--
H
A
Y
L
-
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
--
Q
N
Q
E
Q
L
T
---
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
-
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
A
--
N
A
A
E
--
C
I
L
E
K
W
V
P
F
E
-
K
E
V
S
V
I
V
I
R
S
V
--
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
E
S
I
V
P
A
R
-
I
T
-
E
E
L
S
-
Q
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
N
L
P
L
G
E
T
-
N
-
L
--
L
K
P
V
V
M
V
N
I
L
-
G
E
----------
H
I
--
E
G
----
V
L
R
Q
V
N
R
--
L
T
--
G
C
Y
L
H
L
Y
G
K
E
E
A
-
K
A
Q
R
K
M
G
H
V
N
I
-
L
------------------------
84
HHSearch
68.11
44%
-88
- C2 -
3ORQ
3
?
A:
[4-374]
M
N
F
N
K
L
K
F
G
A
T
I
G
I
I
G
G
G
Q
L
G
K
M
M
A
Q
S
A
Q
K
M
G
Y
K
V
V
V
L
D
P
S
E
D
C
P
C
R
Y
-----
V
--
A
H
E
F
I
Q
A
K
Y
D
D
E
K
A
L
N
Q
L
G
Q
K
C
D
V
I
T
Y
E
F
E
N
I
S
A
Q
Q
L
-
K
L
L
C
E
K
Y
N
I
P
---
Q
G
Y
Q
A
I
Q
L
L
Q
D
R
L
T
E
K
E
T
L
K
S
A
G
T
K
V
V
P
F
I
S
V
--
K
E
S
T
D
I
D
---
K
A
I
E
T
L
G
---
Y
P
F
I
V
K
T
R
-
F
-
G
G
Y
D
G
K
G
Q
V
L
I
N
N
E
K
D
L
Q
E
G
F
K
L
I
--
E
T
S
E
--
C
V
A
E
K
Y
L
N
I
K
-
K
E
V
S
L
T
V
T
R
G
N
--
N
N
Q
I
T
F
F
P
L
Q
E
N
E
H
R
N
Q
I
L
F
K
T
I
V
P
A
R
-
I
D
---
K
T
-
A
E
A
K
E
Q
V
N
K
I
I
Q
S
I
H
F
I
G
T
F
T
V
E
F
F
I
D
S
N
N
Q
L
Y
V
N
E
I
A
P
R
P
H
N
S
G
H
Y
S
I
E
A
C
D
Y
S
Q
F
D
T
H
I
L
A
V
T
G
Q
S
L
P
N
S
-
I
E
L
--
L
K
P
A
V
M
M
N
L
L
-
G
K
D
---------
L
D
--
L
L
-------
E
N
E
F
NE
H
P
--
E
W
H
L
H
I
Y
G
K
S
E
R
-
K
D
S
R
K
M
G
H
M
T
V
-
L
T
N
D
V
N
Q
T
E
Q
D
M
Y
A
K
F
E
--------
82
HHSearch
67.06
40%
-95
- C2 -
4E4T
3
?
A:
[29-413]
--
V
S
P
I
L
P
G
A
W
L
G
M
V
G
G
G
Q
L
G
R
M
F
C
F
A
A
Q
S
M
G
Y
R
V
A
V
L
D
P
D
P
A
S
P
A
G
A
-----
V
--
A
D
R
H
L
R
A
A
Y
D
D
E
A
A
L
A
E
L
A
G
L
C
E
A
V
S
T
E
F
E
N
V
P
A
A
S
L
-
D
F
L
A
---
R
T
T
F
V
A
P
A
G
R
C
V
A
V
A
Q
D
R
I
A
E
K
R
F
I
E
A
S
G
V
P
V
A
P
H
V
V
I
--
E
S
A
A
A
L
A
A
LD
D
A
A
L
D
A
V
---
L
P
G
I
L
K
T
A
R
L
-
G
-
Y
D
G
K
G
Q
V
R
V
S
T
A
R
E
A
R
D
A
H
A
A
L
--
G
G
V
P
--
C
V
L
E
K
R
L
P
-
L
--
K
Y
E
V
S
A
L
I
A
R
G
A
D
G
R
S
A
A
F
P
L
A
Q
N
V
H
H
N
G
I
L
A
L
T
I
V
P
A
P
-
A
A
D
T
A
R
V
-
E
E
A
Q
Q
A
A
V
R
I
A
D
T
L
G
Y
V
G
V
L
C
V
E
F
F
V
L
E
D
G
S
F
V
A
N
E
M
A
P
R
P
H
N
S
G
H
Y
T
V
D
A
C
A
T
S
Q
F
E
Q
Q
V
R
A
M
T
R
M
P
L
G
N
P
-
R
-
Q
--
H
S
P
A
A
M
L
N
I
L
-
G
D
VWFP------
N
G
--
A
A
A
G
A
V
T
P
P
W
D
T
V
A
A
M
P
--
A
A
H
L
H
L
Y
G
K
E
E
A
-
R
V
G
R
K
M
G
H
V
N
F
-
T
A
E
M
R
D
D
A
V
A
A
A
T
A
C
A
Q
L
-------
7
PsiBlast_PDB
67.04
42%
-85
- C2 -
3ORQ
3
?
A:
[12-373]
--------
G
A
T
I
G
I
I
G
G
G
Q
L
G
K
M
M
A
Q
S
A
Q
K
M
G
Y
K
V
V
V
L
D
P
S
E
D
C
P
C
R
Y
-----
V
--
A
H
E
F
I
Q
A
K
Y
D
D
E
K
A
L
N
Q
L
G
Q
K
C
D
V
I
T
Y
E
F
E
N
I
S
A
Q
Q
L
-
K
L
L
C
E
--
K
Y
N
I
-
P
Q
G
Y
Q
A
I
Q
L
L
Q
D
R
L
T
E
K
E
T
L
K
S
A
G
T
K
V
V
P
F
I
S
V
--
K
E
S
T
D
I
D
---
K
A
I
E
T
L
G
---
Y
P
F
I
V
K
T
R
-
F
G
G
-
Y
D
G
K
G
Q
V
L
I
N
N
E
K
D
L
Q
E
G
F
K
L
I
--
E
T
S
E
--
C
V
A
E
K
Y
L
N
I
K
-
K
E
V
S
L
T
V
T
R
G
N
--
N
N
Q
I
T
F
F
P
L
Q
E
N
E
H
R
N
Q
I
L
F
K
T
I
V
P
A
R
-
I
D
-
K
T
A
E
---
A
K
E
Q
V
N
K
I
I
Q
S
I
H
F
I
G
T
F
T
V
E
F
F
I
D
S
N
N
Q
L
Y
V
N
E
I
A
P
R
P
H
N
S
G
H
Y
S
I
E
A
C
D
Y
S
Q
F
D
T
H
I
L
A
V
T
G
Q
S
L
P
N
S
I
E
-
L
--
L
K
P
A
V
M
M
N
L
L
-
G
K
----------
D
L
--
D
L
----
L
E
N
E
F
N
E
--
H
P
--
E
W
H
L
H
I
Y
G
K
S
E
R
-
K
D
S
R
K
M
G
H
M
T
V
-
L
T
N
D
V
N
Q
T
E
Q
D
M
Y
A
K
F
---------
8
PsiBlast_PDB
66.06
42%
-87
- C2 -
3ORR
-
?
A:
[9-370]
--------
G
A
T
I
G
I
I
G
G
G
Q
L
G
K
M
M
A
Q
S
A
Q
K
M
G
Y
K
V
V
V
L
D
P
S
E
D
C
P
C
R
Y
-----
V
--
A
H
E
F
I
Q
A
K
Y
D
D
E
K
A
L
N
Q
L
G
Q
K
C
D
V
I
T
Y
E
F
E
N
I
S
A
Q
Q
L
-
K
L
L
C
E
--
K
Y
N
I
-
P
Q
G
Y
Q
A
I
Q
L
L
Q
D
R
L
T
E
K
E
T
L
K
S
A
G
T
K
V
V
P
F
I
S
V
--
K
E
S
T
D
I
D
---
K
A
I
E
T
L
G
---
Y
P
F
I
V
K
T
R
-
F
G
------
G
Q
V
L
I
N
N
E
K
D
L
Q
E
G
F
K
L
I
--
E
T
S
E
--
C
V
A
E
K
Y
L
N
I
K
-
K
E
V
S
L
T
V
T
R
G
N
--
N
N
Q
I
T
F
F
P
L
Q
E
N
E
H
R
N
Q
I
L
F
K
T
I
V
P
A
R
-
I
D
-
K
T
A
E
---
A
K
E
Q
V
N
K
I
I
Q
S
I
H
F
I
G
T
F
T
V
E
F
F
I
D
S
N
N
Q
L
Y
V
N
E
I
A
P
R
P
H
N
S
G
H
Y
S
I
E
A
C
D
Y
S
Q
F
D
T
H
I
L
A
V
T
G
Q
S
L
P
N
S
I
E
-
L
--
L
K
P
A
V
M
M
N
L
L
-
G
K
----------
D
L
--
D
L
----
L
E
N
E
F
N
E
--
H
P
--
E
W
H
L
H
I
Y
G
K
S
E
R
-
K
D
S
R
K
M
G
H
M
T
V
-
L
T
N
D
V
N
Q
T
E
Q
D
M
Y
A
K
F
---------
26
PsiBlast_CBE
65.71
39%
-98
- C2 -
4E4T
2
?
B:
[30-402]
---
S
P
I
L
P
G
A
W
L
G
M
V
G
G
G
Q
L
G
R
M
F
C
F
A
A
Q
S
M
G
Y
R
V
A
V
L
D
P
D
P
A
S
P
A
G
A
-----
V
--
A
D
R
H
L
R
A
A
Y
D
D
E
A
A
L
A
E
L
A
G
L
C
E
A
V
S
T
E
F
E
N
V
P
A
A
S
L
-
D
F
L
A
R
--
T
T
F
V
-
A
P
A
G
R
C
V
A
V
A
Q
D
R
I
A
E
K
R
F
I
E
A
S
G
V
P
V
A
P
H
V
V
I
--
E
S
A
A
A
L
A
---
A
L
D
D
A
A
L
D
A
V
L
P
G
I
L
K
T
A
-
R
------
K
G
Q
V
R
V
S
T
A
R
E
A
R
D
A
H
A
A
L
--
G
G
V
P
--
C
V
L
E
K
R
L
P
L
K
-
Y
E
V
S
A
L
I
A
R
G
A
--
D
G
R
S
A
A
F
P
L
A
Q
N
V
H
H
N
G
I
L
A
L
T
I
V
P
A
P
-
A
A
-
D
T
A
R
V
E
E
A
Q
Q
A
A
V
R
I
A
D
T
L
G
Y
V
G
V
L
C
V
E
F
F
V
L
E
D
G
S
F
V
A
N
E
M
A
P
R
P
H
N
S
G
H
Y
T
V
D
A
C
A
T
S
Q
F
E
Q
Q
V
R
A
M
T
R
M
P
L
G
N
P
-
R
-
Q
--
H
S
P
A
A
M
L
N
I
L
-
G
D
VWFPNGAAA
G
A
V
--
T
P
----
P
W
D
T
V
A
A
--
M
P
--
A
A
H
L
H
L
Y
G
K
E
E
A
-
R
V
G
R
K
M
G
H
V
N
F
-
T
A
E
M
R
D
D
------------------
6
PsiBlast_PDB
65.42
39%
-94
- C2 -
4E4T
3
?
A:
[29-402]
--
V
S
P
I
L
P
G
A
W
L
G
M
V
G
G
G
Q
L
G
R
M
F
C
F
A
A
Q
S
M
G
Y
R
V
A
V
L
D
P
D
P
A
S
P
A
G
A
-----
V
--
A
D
R
H
L
R
A
A
Y
D
D
E
A
A
L
A
E
L
A
G
L
C
E
A
V
S
T
E
F
E
N
V
P
A
A
S
L
-
D
F
L
A
R
--
T
T
F
V
-
A
P
A
G
R
C
V
A
V
A
Q
D
R
I
A
E
K
R
F
I
E
A
S
G
V
P
V
A
P
H
V
V
I
--
E
S
A
A
A
L
A
---
A
L
D
D
A
A
L
D
A
V
L
P
G
I
L
K
T
A
-
R
L
G
-
Y
D
G
K
G
Q
V
R
V
S
T
A
R
E
A
R
D
A
H
A
A
L
--
G
G
V
P
--
C
V
L
E
K
R
L
P
L
K
-
Y
E
V
S
A
L
I
A
R
G
A
--
D
G
R
S
A
A
F
P
L
A
Q
N
V
H
H
N
G
I
L
A
L
T
I
V
P
A
P
-
A
A
-
D
T
A
R
V
E
E
A
Q
Q
A
A
V
R
I
A
D
T
L
G
Y
V
G
V
L
C
V
E
F
F
V
L
E
D
G
S
F
V
A
N
E
M
A
P
R
P
H
N
S
G
H
Y
T
V
D
A
C
A
T
S
Q
F
E
Q
Q
V
R
A
M
T
R
M
P
L
G
N
P
-
R
-
Q
--
H
S
P
A
A
M
L
N
I
L
-
G
D
VWFPNGAAA
G
A
V
--
T
P
----
P
W
D
T
V
A
A
--
M
P
--
A
A
H
L
H
L
Y
G
K
E
E
A
-
R
V
G
R
K
M
G
H
V
N
F
-
T
A
E
M
R
D
D
------------------
91
HHSearch
63.59
43%
-98
- C2 -
3AX6
1
?
A:
[1-367]
--------
M
K
K
I
G
I
I
G
G
G
Q
L
G
K
M
M
T
L
E
A
K
K
M
G
F
Y
V
I
V
L
D
P
T
P
R
S
P
A
G
Q
-----
V
--
A
D
E
Q
I
V
A
G
F
F
D
S
E
R
I
E
D
L
V
K
G
S
D
V
T
T
Y
D
L
E
H
I
D
V
Q
T
L
-
K
K
L
Y
N
E
-
G
Y
K
I
-
H
P
S
P
Y
T
L
E
I
I
Q
D
K
F
V
Q
K
E
F
L
K
K
N
G
I
P
V
P
E
Y
K
L
V
--
K
D
L
E
S
------
D
V
R
E
F
G
---
F
P
V
V
Q
K
A
R
-
K
G
------
G
V
F
I
I
K
N
E
K
D
L
E
N
A
I
K
------
G
E
--
T
Y
L
E
E
F
V
E
-
I
E
K
E
L
A
V
M
V
A
R
N
E
--
K
G
E
I
A
C
Y
P
V
V
E
M
Y
------
D
T
V
I
A
P
A
R
-
I
E
-
E
K
Y
S
-
K
I
A
R
E
I
A
T
S
V
V
E
A
L
E
G
V
G
I
F
G
I
E
M
F
L
T
K
Q
G
E
I
L
V
N
E
I
A
P
R
P
H
N
S
G
H
Y
T
I
E
A
C
V
T
S
Q
F
E
Q
H
I
R
A
I
M
N
L
P
L
G
S
T
-
E
-
L
--
L
I
P
A
V
M
V
N
L
L
-
G
E
----------
E
G
--
Y
Y
G
K
P
A
L
I
G
L
E
E
A
L
A
I
E
--
G
L
S
L
H
F
Y
G
K
K
E
T
-
R
P
Y
R
K
M
G
H
F
T
V
-
V
D
R
D
V
E
R
A
L
E
K
A
L
R
A
K
K
I
-------
87
HHSearch
62.80
34%
-85
- C2 -
3K5I
5
?
A:
[21-399]
-----
M
W
N
S
R
K
V
G
V
L
G
G
G
Q
L
G
R
M
L
V
E
S
A
N
R
L
N
I
Q
V
N
V
L
D
A
D
N
-
S
P
A
K
Q
-----
I
SA
H
D
G
H
V
T
G
S
F
K
E
R
E
A
V
R
Q
L
A
K
T
C
D
V
V
T
A
E
I
E
H
V
D
T
Y
A
L
-
E
E
V
A
S
--
E
V
K
I
-
E
P
S
W
Q
A
I
R
T
I
Q
N
K
F
N
Q
K
E
H
L
R
K
Y
G
I
P
M
A
E
H
R
E
L
VE
N
T
P
A
E
L
A
---
K
V
G
E
Q
L
G
---
Y
P
L
M
L
K
S
K
-
T
-
M
A
Y
D
G
R
G
N
F
R
V
N
S
Q
D
D
I
P
E
A
L
E
A
L
--
K
D
R
P
--
L
Y
A
E
K
W
A
Y
F
K
-
M
E
L
A
V
I
V
V
K
T
---
K
D
E
V
L
S
Y
P
T
V
E
T
V
Q
E
D
S
I
C
K
L
V
Y
A
P
A
R
N
V
S
-
D
A
I
N
-
Q
K
A
Q
E
L
A
R
K
A
V
A
A
F
D
G
K
G
V
F
G
V
E
M
F
L
L
E
D
D
S
I
M
L
C
E
I
A
S
R
I
H
N
S
G
H
Y
T
I
E
G
C
A
L
S
Q
F
D
A
H
L
R
A
I
L
D
L
P
I
P
A
Q
-
S
-
L
EI
R
Q
P
S
I
M
L
N
I
I
-
G
G
----------
A
A
PD
T
H
----
L
Q
A
A
E
C
A
L
S
I
P
--
N
A
S
I
H
L
Y
-
S
K
G
A
A
K
P
G
R
K
M
G
H
I
T
V
-
T
A
P
T
M
H
E
A
E
T
H
I
Q
P
L
I
D
V
V
D
-----
88
HHSearch
62.48
38%
-93
* C2 *
3AW8
2
?
A:
[1-360]
----------
M
I
G
I
L
G
G
G
Q
L
G
R
M
L
A
L
A
G
Y
P
L
G
L
S
F
R
F
L
D
P
S
P
E
A
C
A
G
Q
-----
V
--
G
E
-
L
V
V
G
E
F
L
D
E
G
A
L
L
R
F
A
E
G
L
A
L
V
T
Y
E
F
E
N
V
P
V
E
A
A
-
R
R
L
E
G
--
R
L
P
L
-
Y
P
P
A
K
A
L
E
V
A
Q
D
R
L
R
E
K
T
F
F
Q
G
L
G
V
P
T
P
P
F
H
P
V
--
D
G
P
E
D
L
E
---
E
G
L
K
R
V
G
---
L
P
A
L
L
K
T
R
-
R
-------
G
Q
A
L
V
R
T
E
E
E
A
L
E
A
L
K
A
L
--
G
G
R
G
--
L
I
L
E
G
F
V
P
F
D
-
R
E
V
S
L
L
A
V
R
G
R
--
T
G
E
V
A
F
Y
P
L
V
E
N
R
H
W
G
G
I
L
R
L
S
L
A
P
A
P
G
A
S
-
E
A
L
Q
-
K
K
A
E
A
Y
A
L
R
A
M
E
A
L
D
Y
V
G
V
L
A
L
E
F
F
Q
V
G
-
E
E
L
L
F
N
E
M
A
P
R
V
H
N
S
G
H
W
T
I
E
G
A
E
T
S
Q
F
E
N
H
L
R
A
V
L
G
L
P
L
G
S
T
-
A
-
P
--
R
G
Q
S
A
M
V
N
L
I
-
G
E
----------
K
P
----------
P
F
A
E
V
L
K
V
E
--
G
A
H
L
H
W
Y
G
K
A
-
V
-
R
P
G
R
K
V
G
H
I
T
L
-
R
R
D
G
L
K
A
L
E
E
G
L
A
R
L
S
R
L
V
------
14
PsiBlast_PDB
61.29
35%
-95
- C2 -
4MAM
3
?
A:
[3-350]
-----------
I
G
I
I
G
A
G
Q
L
A
R
M
L
S
L
A
G
T
P
L
G
L
E
F
H
C
L
G
--
K
N
G
D
C
A
E
EVVK
T
V
--
T
D
I
E
L
T
-
K
V
N
D
---
V
V
A
W
A
K
Q
F
D
V
I
T
F
E
N
E
N
I
S
H
E
L
I
-
K
A
I
N
H
--
E
V
S
V
-
Y
P
S
A
K
A
I
A
I
S
Q
D
R
L
L
E
K
S
F
M
Q
D
H
G
I
A
T
A
K
F
V
N
I
--
D
S
L
A
K
L
Q
---
S
A
V
D
D
H
G
---
L
P
A
I
L
K
T
R
-
R
F
G
-
Y
D
G
K
G
Q
F
V
I
R
S
Q
E
D
I
T
K
A
W
D
V
L
--
K
D
A
P
D
G
L
I
Y
E
A
F
V
D
F
D
-
Y
E
V
S
Q
I
C
T
A
D
L
--
K
G
N
I
A
F
Y
P
L
A
R
N
T
H
K
Q
G
I
I
V
E
S
E
A
P
F
E
--
N
-
V
V
L
A
-
E
K
A
Q
Q
I
A
K
I
L
V
K
E
F
A
Y
V
G
T
L
A
I
E
F
F
V
K
G
D
-
E
L
I
V
N
E
I
A
P
R
V
H
N
S
G
H
W
S
I
D
G
A
V
T
S
Q
F
E
N
H
V
R
A
I
A
G
L
I
L
G
D
T
-
T
-
S
--
R
K
T
-
V
M
L
N
C
I
-
G
G
----------
M
P
--------
A
T
K
D
L
A
A
--
L
D
--
R
V
K
I
H
S
Y
N
K
-
E
P
-
R
K
G
R
K
V
G
H
L
N
L
N
L
N
D
E
T
D
E
Y
-----------------
86
HHSearch
60.89
34%
-92
- C2 -
4MAM
3
?
A:
[1-356]
---------
M
K
I
G
I
I
G
A
G
Q
L
A
R
M
L
S
L
A
G
T
P
L
G
L
E
F
H
C
L
G
K
N
G
D
C
A
-
E
E
-----
V
--
V
K
T
V
T
D
I
E
L
T
K
V
N
D
V
V
A
W
A
K
Q
F
D
V
I
T
F
E
N
E
N
I
S
H
E
L
I
-
K
A
I
N
H
--
E
V
S
V
-
Y
P
S
A
K
A
I
A
I
S
Q
D
R
L
L
E
K
S
F
M
Q
D
H
G
I
A
T
A
K
F
V
N
I
--
D
S
L
A
K
L
Q
---
S
A
V
D
D
H
G
---
L
P
A
I
L
K
T
R
R
F
-
G
-
Y
D
G
K
G
Q
F
V
I
R
S
Q
E
D
I
T
K
A
W
D
V
L
KD
A
P
D
G
--
L
I
Y
E
A
F
V
D
F
D
-
Y
E
V
S
Q
I
C
T
A
D
L
--
K
G
N
I
A
F
Y
P
L
A
R
N
T
H
K
Q
G
I
I
V
E
S
E
A
P
F
E
-
N
--
V
V
L
A
-
E
K
A
Q
Q
I
A
K
I
L
V
K
E
F
A
Y
V
G
T
L
A
I
E
F
F
V
K
G
-
D
E
L
I
V
N
E
I
A
P
R
V
H
N
S
G
H
W
S
I
D
G
A
V
T
S
Q
F
E
N
H
V
R
A
I
A
G
L
I
L
G
D
T
-
T
-
S
--
R
-
K
T
V
M
L
N
C
I
-
G
G
----------
M
P
--
A
--------
T
K
D
L
A
A
L
D
--
R
V
K
I
H
S
Y
N
K
-
E
P
-
R
K
G
R
K
V
G
H
L
N
L
-
N
L
N
D
E
T
D
E
Y
Q
L
L
Q
V
K
----------
15
PsiBlast_PDB
60.77
35%
-96
- C2 -
4M9U
12
?
A:
[3-350]
-----------
I
G
I
I
G
A
G
Q
L
A
R
M
L
S
L
A
G
T
P
L
G
L
E
F
H
C
L
G
--
K
N
G
D
C
A
E
EVVK
T
V
--
T
D
I
E
L
T
-
K
V
N
D
---
V
V
A
W
A
K
Q
F
D
V
I
T
F
E
N
E
N
I
S
H
E
L
I
-
K
A
I
N
H
--
E
V
S
V
-
Y
P
S
A
K
A
I
A
I
S
Q
D
R
L
L
E
K
S
F
M
Q
D
H
G
I
A
T
A
K
F
V
N
I
--
D
S
L
A
K
L
Q
---
S
A
V
D
D
H
G
---
L
P
A
I
L
K
T
R
-
R
F
G
-
Y
D
G
K
G
Q
F
V
I
R
S
Q
E
D
I
T
K
A
W
D
V
L
--
K
D
A
P
D
G
L
I
Y
E
A
F
V
D
F
D
-
Y
E
V
S
Q
I
C
T
A
D
L
--
K
G
N
I
A
F
Y
P
L
A
R
N
T
H
K
Q
G
I
I
V
E
S
E
A
P
F
E
--
N
-
V
V
L
A
-
E
K
A
Q
Q
I
A
K
I
L
V
K
E
F
A
Y
V
G
T
L
A
I
E
F
F
V
K
G
D
-
E
L
I
V
N
E
I
A
P
R
V
H
N
S
G
H
W
S
I
D
G
A
V
T
S
Q
F
E
N
H
V
R
A
I
A
G
L
I
L
G
D
T
-
T
-
S
--
R
K
T
-
V
M
L
N
C
I
-
G
G
----------
M
P
--------
A
T
K
D
L
A
A
--
L
D
--
R
V
K
I
H
S
Y
N
K
-
E
P
-
R
K
G
R
K
V
G
H
L
N
L
N
L
N
D
E
T
D
E
Y
-----------------
12
PsiBlast_PDB
60.25
35%
-95
- C2 -
4MA0
4
?
A:
[3-350]
-----------
I
G
I
I
G
A
G
Q
L
A
R
M
L
S
L
A
G
T
P
L
G
L
E
F
H
C
L
G
--
K
N
G
D
C
A
E
EVVK
T
V
--
T
D
I
E
L
T
-
K
V
N
D
---
V
V
A
W
A
K
Q
F
D
V
I
T
F
E
N
E
N
I
S
H
E
L
I
-
K
A
I
N
H
--
E
V
S
V
-
Y
P
S
A
K
A
I
A
I
S
Q
D
R
L
L
E
K
S
F
M
Q
D
H
G
I
A
T
A
K
F
V
N
I
--
D
S
L
A
K
L
Q
---
S
A
V
D
D
H
G
---
L
P
A
I
L
K
T
R
-
R
F
G
-
Y
D
G
K
G
Q
F
V
I
R
S
Q
E
D
I
T
K
A
W
D
V
L
--
K
D
A
P
D
G
L
I
Y
E
A
F
V
D
F
D
-
Y
E
V
S
Q
I
C
T
A
D
L
--
K
G
N
I
A
F
Y
P
L
A
R
N
T
H
K
Q
G
I
I
V
E
S
E
A
P
F
E
--
N
-
V
V
L
A
-
E
K
A
Q
Q
I
A
K
I
L
V
K
E
F
A
Y
V
G
T
L
A
I
E
F
F
V
K
G
D
-
E
L
I
V
N
E
I
A
P
R
V
H
N
S
G
H
W
S
I
D
G
A
V
T
S
Q
F
E
N
H
V
R
A
I
A
G
L
I
L
G
D
T
-
T
-
S
--
R
K
T
-
V
M
L
N
C
I
-
G
G
----------
M
P
--------
A
T
K
D
L
A
A
--
L
D
--
R
V
K
I
H
S
Y
N
K
-
E
P
-
R
K
G
R
K
V
G
H
L
N
L
N
L
N
D
E
T
D
E
Y
-----------------
13
PsiBlast_PDB
60.00
35%
-99
- C2 -
4MA5
5
?
A:
[3-350]
-----------
I
G
I
I
G
A
G
Q
L
A
R
M
L
S
L
A
G
T
P
L
G
L
E
F
H
C
L
G
--
K
N
G
D
C
A
E
EVVK
T
V
--
T
D
I
E
L
T
-
K
V
N
D
---
V
V
A
W
A
K
Q
F
D
V
I
T
F
E
N
E
N
I
S
H
E
L
I
-
K
A
I
N
H
--
E
V
S
V
-
Y
P
S
A
K
A
I
A
I
S
Q
D
R
L
L
E
K
S
F
M
Q
D
H
G
I
A
T
A
K
F
V
N
I
--
D
S
L
A
K
L
Q
---
S
A
V
D
D
H
G
---
L
P
A
I
L
K
T
R
-
R
F
G
-
Y
D
G
K
G
Q
F
V
I
R
S
Q
E
D
I
T
K
A
W
D
V
L
--
K
D
A
P
D
G
L
I
Y
E
A
F
V
D
F
D
-
Y
E
V
S
Q
I
C
T
A
D
L
--
K
G
N
I
A
F
Y
P
L
A
R
N
T
H
K
Q
G
I
I
V
E
S
E
A
P
F
E
--
N
-
V
V
L
A
-
E
K
A
Q
Q
I
A
K
I
L
V
K
E
F
A
Y
V
G
T
L
A
I
E
F
F
V
K
---
E
L
I
V
N
E
I
A
P
R
V
H
N
S
G
H
W
S
I
D
G
A
V
T
S
Q
F
E
N
H
V
R
A
I
A
G
L
I
L
G
D
T
-
T
-
S
--
R
K
T
-
V
M
L
N
C
I
-
G
G
----------
M
P
--------
A
T
K
D
L
A
A
--
L
D
--
R
V
K
I
H
S
Y
N
K
-
E
P
-
R
K
G
R
K
V
G
H
L
N
L
N
L
N
D
E
T
D
E
Y
-----------------
10
PsiBlast_PDB
57.62
38%
-92
- C2 -
3AW8
2
?
A:
[12-343]
---------------------
R
M
L
A
L
A
G
Y
P
L
G
L
S
F
R
F
L
D
P
S
P
E
A
C
A
G
Q
-----
V
--
G
E
L
-
V
V
G
E
F
L
D
E
G
A
L
L
R
F
A
E
G
L
A
L
V
T
Y
E
F
E
N
V
P
V
E
A
A
-
R
R
L
E
G
--
R
L
P
L
-
Y
P
P
A
K
A
L
E
V
A
Q
D
R
L
R
E
K
T
F
F
Q
G
L
G
V
P
T
P
P
F
H
P
V
--
D
G
P
E
D
L
E
---
E
G
L
K
R
V
G
---
L
P
A
L
L
K
T
R
-
R
G
-------
Q
A
L
V
R
T
E
E
E
A
L
E
A
L
K
A
L
--
G
G
R
G
--
L
I
L
E
G
F
V
P
F
D
-
R
E
V
S
L
L
A
V
R
G
R
--
T
G
E
V
A
F
Y
P
L
V
E
N
R
H
W
G
G
I
L
R
L
S
L
A
P
A
P
G
A
S
-
E
A
L
Q
-
K
K
A
E
A
Y
A
L
R
A
M
E
A
L
D
Y
V
G
V
L
A
L
E
F
F
Q
V
G
E
-
E
L
L
F
N
E
M
A
P
R
V
H
N
S
G
H
W
T
I
E
G
A
E
T
S
Q
F
E
N
H
L
R
A
V
L
G
L
P
L
G
S
T
-
A
-
P
--
R
G
Q
S
A
M
V
N
L
I
-
G
E
----------
K
P
--
P
F
----
A
----
E
V
--
L
K
VE
G
A
H
L
H
W
Y
G
K
-
A
V
-
R
P
G
R
K
V
G
H
I
T
L
-
R
R
-----------------------
27
PsiBlast_CBE
56.71
38%
-95
- C2 -
3AW8
3
?
B:
[12-343]
---------------------
R
M
L
A
L
A
G
Y
P
L
G
L
S
F
R
F
L
D
P
S
P
E
A
C
A
G
Q
-----
V
--
G
E
L
-
V
V
G
E
F
L
D
E
G
A
L
L
R
F
A
E
G
L
A
L
V
T
Y
E
F
E
N
V
P
V
E
A
A
-
R
R
L
E
G
--
R
L
P
L
-
Y
P
P
A
K
A
L
E
V
A
Q
D
R
L
R
E
K
T
F
F
Q
G
L
G
V
P
T
P
P
F
H
P
V
--
D
G
P
E
D
L
E
---
E
G
L
K
R
V
G
---
L
P
A
L
L
K
T
R
-
R
G
-------
Q
A
L
V
R
T
E
E
E
A
L
E
A
L
K
A
L
--
G
G
R
G
--
L
I
L
E
G
F
V
P
F
D
-
R
E
V
S
L
L
A
V
R
G
R
--
T
G
E
V
A
F
Y
P
L
V
E
N
R
H
W
G
G
I
L
R
L
S
L
A
P
A
P
G
A
S
-
E
A
L
Q
-
K
K
A
E
A
Y
A
L
R
A
M
E
A
L
D
Y
V
G
V
L
A
L
E
F
F
Q
V
G
E
-
E
L
L
F
N
E
M
A
P
R
V
H
N
S
G
H
W
T
I
E
G
A
E
T
S
Q
F
E
N
H
L
R
A
V
L
G
L
P
L
G
S
T
-
A
-
P
--
R
G
Q
S
A
M
V
N
L
I
-
G
E
----------
K
P
--
P
F
----
A
----
E
V
--
L
K
VE
G
A
H
L
H
W
Y
G
K
-
A
V
-
R
P
G
R
K
V
G
H
I
T
L
-
R
R
-----------------------
20
PsiBlast_PDB
54.48
31%
-109
- C2 -
3ETH
3
PURK_ECOLI
A:
[4-320]
-----------
V
C
V
L
G
N
G
Q
L
G
R
M
L
R
Q
A
G
E
P
L
G
I
A
V
W
--------
P
V
G
---------
L
D
A
E
P
A
A
----------
V
P
F
Q
Q
S
V
I
T
A
E
I
E
R
W
P
E
T
A
L
T
R
Q
L
A
R
--
H
P
A
F
--
V
N
R
D
V
F
P
I
I
A
D
R
L
T
Q
K
Q
L
F
D
K
L
H
L
P
T
A
P
W
Q
L
L
--
A
E
R
S
E
W
P
---
A
V
F
D
R
L
G
---
E
L
A
I
V
K
R
R
-
T
G
G
-
Y
D
G
R
G
Q
W
R
L
R
A
N
-
E
T
E
Q
L
P
A
E
C
---
Y
G
E
--
C
I
V
E
Q
G
I
N
F
S
-
G
E
V
S
L
V
G
A
R
G
F
--
D
G
S
T
V
F
Y
P
L
T
H
N
L
H
Q
D
G
I
L
R
T
S
V
A
F
P
Q
-
A
N
-
A
Q
Q
Q
-
A
R
A
E
E
M
L
S
A
I
M
Q
E
L
G
Y
V
G
V
M
A
M
E
C
F
V
T
P
Q
G
-
L
L
I
N
E
L
A
P
R
V
H
N
S
G
H
W
T
Q
N
G
A
S
I
S
Q
F
E
L
H
L
R
A
I
T
D
L
P
L
P
Q
P
-
V
-
V
--
N
N
P
S
V
M
I
N
L
I
-
G
S
----------
D
V
--
N
Y
-------
D
W
L
K
--
L
P
--
L
V
H
L
H
W
Y
D
K
-
E
V
-
R
P
G
R
K
V
G
H
L
N
L
--------------------------
37
PsiBlast_CBE
54.10
31%
-111
- C2 -
3ETJ
5
PURK_ECOLI
A:
[4-320]
-----------
V
C
V
L
G
N
G
Q
L
G
R
M
L
R
Q
A
G
E
P
L
G
I
A
V
W
--------
P
V
G
---------
L
D
A
E
P
A
A
----------
V
P
F
Q
Q
S
V
I
T
A
E
I
E
R
W
P
E
T
A
L
T
R
Q
L
A
R
--
H
P
A
F
--
V
N
R
D
V
F
P
I
I
A
D
R
L
T
Q
K
Q
L
F
D
K
L
H
L
P
T
A
P
W
Q
L
L
--
A
E
R
S
E
W
P
---
A
V
F
D
R
L
G
---
E
L
A
I
V
K
R
R
-
T
G
G
-
Y
D
G
R
G
Q
W
R
L
R
A
N
-
E
T
E
Q
L
P
A
E
C
---
Y
G
E
--
C
I
V
E
Q
G
I
N
F
S
-
G
E
V
S
L
V
G
A
R
G
F
--
D
G
S
T
V
F
Y
P
L
T
H
N
L
H
Q
D
G
I
L
R
T
S
V
A
F
P
Q
-
A
N
-
A
Q
Q
Q
-
A
R
A
E
E
M
L
S
A
I
M
Q
E
L
G
Y
V
G
V
M
A
M
E
C
F
V
T
P
Q
G
-
L
L
I
N
E
L
A
P
R
V
H
N
S
G
H
W
T
Q
N
G
A
S
I
S
Q
F
E
L
H
L
R
A
I
T
D
L
P
L
P
Q
P
-
V
-
V
--
N
N
P
S
V
M
I
N
L
I
-
G
S
----------
D
V
--
N
Y
-------
D
W
L
K
--
L
P
--
L
V
H
L
H
W
Y
D
K
-
E
V
-
R
P
G
R
K
V
G
H
L
N
L
--------------------------
36
PsiBlast_CBE
53.71
31%
-117
- C2 -
3ETJ
4
PURK_ECOLI
B:
[4-320]
-----------
V
C
V
L
G
N
G
Q
L
G
R
M
L
R
Q
A
G
E
P
L
G
I
A
V
W
--------
P
V
G
---------
L
D
A
E
P
A
A
----------
V
P
F
Q
Q
S
V
I
T
A
E
I
E
R
W
P
E
T
A
L
T
R
Q
L
A
R
--
H
P
A
F
--
V
N
R
D
V
F
P
I
I
A
D
R
L
T
Q
K
Q
L
F
D
K
L
H
L
P
T
A
P
W
Q
L
L
--
A
E
R
S
E
W
P
---
A
V
F
D
R
L
G
---
E
L
A
I
V
K
R
R
-
T
G
G
-----
G
Q
W
R
L
R
A
N
-
E
T
E
Q
L
P
A
E
C
---
Y
G
E
--
C
I
V
E
Q
G
I
N
F
S
-
G
E
V
S
L
V
G
A
R
G
F
--
D
G
S
T
V
F
Y
P
L
T
H
N
L
H
Q
D
G
I
L
R
T
S
V
A
F
P
Q
-
A
N
-
A
Q
Q
Q
-
A
R
A
E
E
M
L
S
A
I
M
Q
E
L
G
Y
V
G
V
M
A
M
E
C
F
V
T
P
Q
G
-
L
L
I
N
E
L
A
P
R
V
H
N
S
G
H
W
T
Q
N
G
A
S
I
S
Q
F
E
L
H
L
R
A
I
T
D
L
P
L
P
Q
P
-
V
-
V
--
N
N
P
S
V
M
I
N
L
I
-
G
S
----------
D
V
--
N
Y
-------
D
W
L
K
--
L
P
--
L
V
H
L
H
W
Y
D
K
-
E
V
-
R
P
G
R
K
V
G
H
L
N
L
--------------------------
38
PsiBlast_CBE
53.60
31%
-111
- C2 -
3ETH
3
PURK_ECOLI
B:
[4-320]
-----------
V
C
V
L
G
N
G
Q
L
G
R
M
L
R
Q
A
G
E
P
L
G
I
A
V
W
--------
P
V
G
---------
L
D
A
E
P
A
A
----------
V
P
F
Q
Q
S
V
I
T
A
E
I
E
R
W
P
E
T
A
L
T
R
Q
L
A
R
--
H
P
A
F
--
V
N
R
D
V
F
P
I
I
A
D
R
L
T
Q
K
Q
L
F
D
K
L
H
L
P
T
A
P
W
Q
L
L
--
A
E
R
S
E
W
P
---
A
V
F
D
R
L
G
---
E
L
A
I
V
K
R
R
-
T
G
G
-
Y
D
G
R
G
Q
W
R
L
R
A
N
-
E
T
E
Q
L
P
A
E
C
---
Y
G
E
--
C
I
V
E
Q
G
I
N
F
S
-
G
E
V
S
L
V
G
A
R
G
F
--
D
G
S
T
V
F
Y
P
L
T
H
N
L
H
Q
D
G
I
L
R
T
S
V
A
F
P
Q
-
A
N
-
A
Q
Q
Q
-
A
R
A
E
E
M
L
S
A
I
M
Q
E
L
G
Y
V
G
V
M
A
M
E
C
F
V
T
P
Q
G
-
L
L
I
N
E
L
A
P
R
V
H
N
S
G
H
W
T
Q
N
G
A
S
I
S
Q
F
E
L
H
L
R
A
I
T
D
L
P
L
P
Q
P
-
V
-
V
--
N
N
P
S
V
M
I
N
L
I
-
G
S
----------
D
V
--
N
Y
-------
D
W
L
K
--
L
P
--
L
V
H
L
H
W
Y
D
K
-
E
V
-
R
P
G
R
K
V
G
H
L
N
L
--------------------------