@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu11330: (2016-06-17 )
MKAGILGVGRYIPEKVLTNHDLEKMVETSDEWIRTRTGIEERRIAADDVFSSHMAVAAAKNALEQAEVAAEDLDMILVATVTPDQSFPTVSCMIQEQLGAKKACAMDISAACAGFMYGVVTGKQFIESGTYKHVLVVGVEKLSSITDWEDRNTAVLFGDGAGAAVVGPVSDDRGILSFELGADGTGGQHLYLNEKRHTIMNGREVFKFAVRQMGESCVNVIEKAGLSKEDVDFLIPHQANIRIMEAARERLELPVEKMSKTVHKYGNTSAASIPISLVEELEAGKIKDGDVVVMVGFGGGLTWGAIAIRWGR
Atome Classification :
(37 SA)
.........10........20....-....30........40.....-...50----........60........70........80........90........100.......110.......120.......130.......140......-.150.......160.......170.......180..------...-----.----.190----------.-------.------------.------------.--------.-------..-----------.200-------------........210.......220.....-..230.......240.......250.-...-..--.260........270.......280-........290-........300.......310-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKAGIL
G
V
G
R
YI
P
E
K
V
LT
N
H
D
L
E
K
M
-
V
E
T
S
D
E
W
I
R
T
RTG
I
E
E
RRI
A
A
-
D
D
V
F
S
----
S
H
M
A
V
A
A
A
K
N
A
L
E
Q
A
E
V
A
A
EDL
D
M
I
L
V
A
TVTPDQSF
P
T
V
S
C
M
I
Q
E
Q
LGAK
K
A
C
A
M
D
I
S
A
A
C
A
G
F
M
Y
G
V
V
T
G
K
Q
F
I
ESGTY
K
H
V
L
V
V
G
V
E
K
L
S
SITDW-EDR
N
T
A
V
L
F
GDGAG
A
A
V
V
GPVSDDR
G
I
L
S
F
E
LGADG------TGG-----
Q
----
H
L
Y
-----------L-------N------------E------------K--------R-------HT-----------IM
N
--------------
G
R
E
V
F
K
F
A
V
R
Q
M
G
E
S
C
V
N
V
I
E
KAGLS-KEDV
D
F
LIPHQANI
R
I
M
E
A
A
R
E
R
LEL-
P
V
E
-
K
M
--
S
K
-
T
V
H
KYGNTSAAS
I
P
I
S
L
V
E
E
L
--EAGKIKDG
D
V
--
V
V
M
V
GFGGG
L
T
W
G
A
I
A
I
RWGR-
77
HHSearch
87.67
53%
-118
- C2 -
2EBD
-
FABH_AQUAE
A:
[1-309]
M
G
T
K
I
I
G
T
G
V
Y
L
P
K
N
V
L
T
N
F
D
L
E
K
I
-
V
D
T
S
D
E
W
I
T
T
R
T
G
I
K
E
R
R
I
A
K
--
E
E
T
I
----
T
Y
M
A
T
Q
A
A
K
E
A
L
R
E
A
N
L
S
P
E
E
L
D
L
I
I
L
A
T
L
T
P
Q
K
R
F
P
S
T
A
C
L
V
Q
A
Q
L
K
A
K
G
V
Y
A
F
D
I
S
A
A
C
S
G
F
I
Y
A
L
D
I
A
D
S
F
I
K
S
G
K
A
K
N
V
L
V
I
G
A
E
K
L
S
E
A
V
D
W
-
E
D
R
S
T
C
V
L
F
G
D
G
A
G
A
V
V
V
T
R
S
E
D
K
S
D
I
L
A
T
R
M
Y
A
E
G
------
S
L
E
-----
E
----
L
L
H
-----------
A
-------
D
------------
N
------------
C
--------
G
-------
Y
I
-----------
R
M
K
--------------
G
R
E
L
F
K
V
A
V
R
S
M
E
E
V
C
R
E
V
L
E
K
A
G
V
K
-
P
E
E
V
S
L
V
I
P
H
Q
A
N
V
R
I
I
N
A
L
A
E
K
L
N
I
-
P
K
E
-
K
V
--
F
V
-
N
I
Q
K
Y
G
N
T
S
A
A
S
I
P
I
A
L
H
E
A
I
--
K
E
G
K
V
K
R
G
D
L
--
I
L
M
T
A
M
G
G
G
L
T
W
G
A
V
L
L
R
Y
---
3
PsiBlast_PDB
87.38
52%
-117
- C2 -
2EBD
-
FABH_AQUAE
A:
[1-309]
M
G
T
K
I
I
G
T
G
V
Y
L
P
K
N
V
L
T
N
F
D
L
E
K
I
-
V
D
T
S
D
E
W
I
T
T
R
T
G
I
K
E
R
R
I
A
K
-
E
E
T
I
T
-----
Y
M
A
T
Q
A
A
K
E
A
L
R
E
A
N
L
S
P
E
E
L
D
L
I
I
L
A
T
L
T
P
Q
K
R
F
P
S
T
A
C
L
V
Q
A
Q
L
K
A
K
G
V
Y
A
F
D
I
S
A
A
C
S
G
F
I
Y
A
L
D
I
A
D
S
F
I
K
S
G
K
A
K
N
V
L
V
I
G
A
E
K
L
S
E
A
V
D
W
-
E
D
R
S
T
C
V
L
F
G
D
G
A
G
A
V
V
V
T
R
S
E
D
K
S
D
I
L
A
T
R
M
Y
A
E
G
------
S
L
E
-----
E
----
L
L
H
-----------
A
-------
D
------------
N
------------
C
--------
G
-------
Y
I
-----------
R
M
K
--------------
G
R
E
L
F
K
V
A
V
R
S
M
E
E
V
C
R
E
V
L
E
K
A
G
V
K
-
P
E
E
V
S
L
V
I
P
H
Q
A
N
V
R
I
I
N
A
L
A
E
K
L
N
I
-
P
K
E
-
K
V
--
F
V
-
N
I
Q
K
Y
G
N
T
S
A
A
S
I
P
I
A
L
H
E
A
I
--
K
E
G
K
V
K
R
G
D
L
--
I
L
M
T
A
M
G
G
G
L
T
W
G
A
V
L
L
R
Y
---
21
PsiBlast_CBE
87.36
50%
-116
- C2 -
1UB7
6
?
D:
[2-320]
--
S
G
I
L
A
L
G
A
Y
V
P
E
R
V
M
T
N
A
D
F
E
A
Y
-
L
D
T
S
D
E
W
I
V
T
R
T
G
I
K
E
R
R
V
A
A
-
E
D
E
Y
T
----
S
D
L
A
F
K
A
V
E
D
L
L
R
R
H
P
G
A
L
E
G
V
D
A
V
I
V
A
T
N
T
P
D
A
L
F
P
D
T
A
A
L
V
Q
A
R
F
G
L
K
-
A
F
A
Y
D
L
L
A
G
C
P
G
W
I
Y
A
L
A
Q
A
H
A
L
V
E
A
G
L
A
Q
K
V
L
A
V
G
A
E
A
L
S
K
I
I
D
W
-
N
D
R
A
T
A
V
L
F
G
D
G
G
G
A
A
V
V
G
K
V
R
E
G
Y
G
F
R
S
F
V
L
G
A
D
G
------
T
G
A
-----
K
----
E
L
Y
HACVAPRLPDG
T
-------
S
------------
M
------------
K
--------
N
-------
R
L
-----------
Y
M
N
--------------
G
R
E
V
F
K
F
A
V
R
V
M
N
T
A
T
L
E
A
I
E
K
A
G
L
T
-
P
E
D
I
R
L
F
V
P
H
Q
A
N
L
R
I
I
D
A
A
R
E
R
L
G
L
-
P
W
E
-
R
V
--
A
V
-
N
V
D
R
Y
G
N
T
S
T
A
S
I
P
L
A
L
K
E
A
V
--
D
A
G
R
I
R
E
G
D
H
--
V
L
L
V
S
F
G
A
G
L
T
W
A
A
A
V
L
T
W
G
--
20
PsiBlast_PDB
85.33
42%
-122
- C2 -
1EBL
1
FABH_ECOLI
A:
[5-317]
----
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
-
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
-
P
N
E
T
V
----
S
T
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
-
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
-
A
S
E
E
P
G
I
I
S
T
H
L
H
A
D
G
------
S
Y
G
-----
E
----
L
L
T
-----------
L
P
------
N
------------
A
------------
D
--------
R
VNPENSI
H
L
-----------
T
M
A
--------------
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
N
D
-
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
-
S
M
D
-
N
V
--
V
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
--
R
D
G
R
I
K
P
G
Q
L
--
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
---
88
Fugue
85.31
53%
-114
* C2 *
1UB7
4
?
A:
[2-322]
--
S
G
I
L
A
L
G
A
Y
V
P
E
R
V
M
T
N
A
D
F
E
A
Y
L-
D
T
S
D
E
W
I
V
T
R
T
G
I
K
E
R
R
V
A
A
E-----DEY
T
S
D
L
A
F
K
A
V
E
D
L
L
R
R
H
P
G
A
L
E
G
V
D
A
V
I
V
A
T
N
T
P
D
A
L
F
P
D
T
A
A
L
V
Q
A
R
F
G
L
K
-
A
F
A
Y
D
L
L
A
G
C
P
G
W
I
Y
A
L
A
Q
A
H
A
L
V
E
A
G
L
A
Q
K
V
L
A
V
G
A
E
A
L
S
K
I
I
D
W
N-
D
R
A
T
A
V
L
F
G
D
G
G
G
A
A
V
V
G
K
V
R
E
G
Y
G
F
R
S
F
V
L
G
A
D
G
------
T
G
A
-----
K
----
E
L
Y
-----------
H
-------
A
------------
C
------------
V
--------
A
-------
P
R
LPDGTSMK
N
R
L
Y
M
N
--------------
G
R
E
V
F
K
F
A
V
R
V
M
N
T
A
T
L
E
A
I
E
K
A
G
L
-T
P
E
D
I
R
L
F
V
P
H
Q
A
N
L
R
I
I
D
A
A
R
E
R
L
G
L
-
P
W
E
-
R
-VA-
V
-
N
V
D
R
Y
G
N
T
S
T
A
S
I
P
L
A
L
K
E
A
V
D
A--
G
R
I
R
E
G
D
H
--
V
L
L
V
S
F
G
A
G
L
T
W
A
A
A
V
L
T
W
G
G
A
22
PsiBlast_CBE
85.30
50%
-112
- C2 -
1UB7
4
?
C:
[2-320]
--
S
G
I
L
A
L
G
A
Y
V
P
E
R
V
M
T
N
A
D
F
E
A
Y
-
L
D
T
S
D
E
W
I
V
T
R
T
G
I
K
E
R
R
V
A
A
-
E
D
E
Y
T
----
S
D
L
A
F
K
A
V
E
D
L
L
R
R
H
P
G
A
L
E
G
V
D
A
V
I
V
A
T
N
T
P
D
A
L
F
P
D
T
A
A
L
V
Q
A
R
F
G
L
K
-
A
F
A
Y
D
L
L
A
G
C
P
G
W
I
Y
A
L
A
Q
A
H
A
L
V
E
A
G
L
A
Q
K
V
L
A
V
G
A
E
A
L
S
K
I
I
D
W
-
N
D
R
A
T
A
V
L
F
G
D
G
G
G
A
A
V
V
G
K
V
R
E
G
Y
G
F
R
S
F
V
L
G
A
D
G
------
T
G
A
-----
K
----
E
L
Y
HACVAPRLPDG
T
-------
S
------------
M
------------
K
--------
N
-------
R
L
-----------
Y
M
N
--------------
G
R
E
V
F
K
F
A
V
R
V
M
N
T
A
T
L
E
A
I
E
K
A
G
L
T
-
P
E
D
I
R
L
F
V
P
H
Q
A
N
L
R
I
I
D
A
A
R
E
R
L
G
L
-
P
W
E
-
R
V
--
A
V
-
N
V
D
R
Y
G
N
T
S
T
A
S
I
P
L
A
L
K
E
A
V
--
D
A
G
R
I
R
E
G
D
H
--
V
L
L
V
S
F
G
A
G
L
T
W
A
A
A
V
L
T
W
G
--
12
PsiBlast_PDB
84.84
44%
-121
- C2 -
2EFT
3
FABH_ECOLI
A:
[1-317]
M
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
-
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
-
P
N
E
T
V
----
S
T
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
-
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
-
A
S
E
E
P
G
I
I
S
T
H
L
H
A
D
G
------
S
Y
G
-----
E
----
L
L
T
-----------
L
P
------
N
------------
A
------------
D
--------
R
VNPENSI
H
L
-----------
T
M
A
--------------
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
-
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
-
S
M
D
-
N
V
--
V
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
--
R
D
G
R
I
K
P
G
Q
L
--
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
---
9
PsiBlast_PDB
84.56
44%
-122
- C2 -
1HND
1
FABH_ECOLI
A:
[1-317]
M
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
-
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
-
P
N
E
T
V
----
S
T
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
-
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
-
A
S
E
E
P
G
I
I
S
T
H
L
H
A
D
G
------
S
Y
G
-----
E
----
L
L
T
-----------
L
P
------
N
------------
A
------------
D
--------
R
VNPENSI
H
L
-----------
T
M
A
--------------
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
-
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
-
S
M
D
-
N
V
--
V
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
--
R
D
G
R
I
K
P
G
Q
L
--
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
---
33
PsiBlast_CBE
84.51
44%
-120
- C2 -
1HN9
1
FABH_ECOLI
B:
[1-317]
M
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
-
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
-
P
N
E
T
V
----
S
T
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
-
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
-
A
S
E
E
P
G
I
I
S
T
H
L
H
A
D
G
------
S
Y
G
-----
E
----
L
L
T
-----------
L
P------
N
------------
A
------------
D
--------
R
VNPENSI
H
L
-----------
T
M
A
--------------
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
-
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
-
S
M
D
-
N
V
--
V
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
--
R
D
G
R
I
K
P
G
Q
L
--
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
---
8
PsiBlast_PDB
84.50
44%
-120
- C2 -
1HN9
1
FABH_ECOLI
A:
[1-317]
M
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
-
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
-
P
N
E
T
V
----
S
T
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
-
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
-
A
S
E
E
P
G
I
I
S
T
H
L
H
A
D
G
------
S
Y
G
-----
E
----
L
L
T
-----------
L
P
------
N
------------
A
------------
D
--------
R
VNPENSI
H
L
-----------
T
M
A
--------------
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
-
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
-
S
M
D
-
N
V
--
V
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
--
R
D
G
R
I
K
P
G
Q
L
--
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
---
13
PsiBlast_PDB
84.33
44%
-119
- C2 -
2GYO
3
FABH_ECOLI
A:
[1-317]
M
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
-
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
-
P
N
E
T
V
----
S
T
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
-
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
-
A
S
E
E
P
G
I
I
S
T
H
L
H
A
D
G
------
S
Y
G
-----
E
----
L
L
T
-----------
L
P
------
N
------------
A
------------
D
--------
R
VNPENSI
H
L
-----------
T
M
A
--------------
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
-
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
-
S
M
D
-
N
V
--
V
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
--
R
D
G
R
I
K
P
G
Q
L
--
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
---
23
PsiBlast_CBE
84.26
50%
-111
- C2 -
1UB7
3
?
B:
[2-320]
--
S
G
I
L
A
L
G
A
Y
V
P
E
R
V
M
T
N
A
D
F
E
A
Y
-
L
D
T
S
D
E
W
I
V
T
R
T
G
I
K
E
R
R
V
A
A
-
E
D
E
Y
T
----
S
D
L
A
F
K
A
V
E
D
L
L
R
R
H
P
G
A
L
E
G
V
D
A
V
I
V
A
T
N
T
P
D
A
L
F
P
D
T
A
A
L
V
Q
A
R
F
G
L
K
-
A
F
A
Y
D
L
L
A
G
C
P
G
W
I
Y
A
L
A
Q
A
H
A
L
V
E
A
G
L
A
Q
K
V
L
A
V
G
A
E
A
L
S
K
I
I
D
W
-
N
D
R
A
T
A
V
L
F
G
D
G
G
G
A
A
V
V
G
K
V
R
E
G
Y
G
F
R
S
F
V
L
G
A
D
G
------
T
G
A
-----
K
----
E
L
Y
HACVAPRLPDG
T
-------
S
------------
M
------------
K
--------
N
-------
R
L
-----------
Y
M
N
--------------
G
R
E
V
F
K
F
A
V
R
V
M
N
T
A
T
L
E
A
I
E
K
A
G
L
T
-
P
E
D
I
R
L
F
V
P
H
Q
A
N
L
R
I
I
D
A
A
R
E
R
L
G
L
-
P
W
E
-
R
V
--
A
V
-
N
V
D
R
Y
G
N
T
S
T
A
S
I
P
L
A
L
K
E
A
V
--
D
A
G
R
I
R
E
G
D
H
--
V
L
L
V
S
F
G
A
G
L
T
W
A
A
A
V
L
T
W
G
--
31
PsiBlast_CBE
84.19
44%
-120
- C2 -
2GYO
3
FABH_ECOLI
B:
[1-317]
M
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
-
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
-
P
N
E
T
V
----
S
T
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
-
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
-
A
S
E
E
P
G
I
I
S
T
H
L
H
A
D
G
------
S
Y
G
-----
E
----
L
L
T
-----------
L
P------
N
------------
A
------------
D
--------
R
VNPENSI
H
L
-----------
T
M
A
--------------
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
-
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
-
S
M
D
-
N
V
--
V
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
--
R
D
G
R
I
K
P
G
Q
L
--
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
---
4
PsiBlast_PDB
83.40
50%
-111
- C2 -
1UB7
4
?
A:
[2-320]
--
S
G
I
L
A
L
G
A
Y
V
P
E
R
V
M
T
N
A
D
F
E
A
Y
-
L
D
T
S
D
E
W
I
V
T
R
T
G
I
K
E
R
R
V
A
A
-
E
D
E
Y
T
----
S
D
L
A
F
K
A
V
E
D
L
L
R
R
H
P
G
A
L
E
G
V
D
A
V
I
V
A
T
N
T
P
D
A
L
F
P
D
T
A
A
L
V
Q
A
R
F
G
L
K
-
A
F
A
Y
D
L
L
A
G
C
P
G
W
I
Y
A
L
A
Q
A
H
A
L
V
E
A
G
L
A
Q
K
V
L
A
V
G
A
E
A
L
S
K
I
I
D
W
-
N
D
R
A
T
A
V
L
F
G
D
G
G
G
A
A
V
V
G
K
V
R
E
G
Y
G
F
R
S
F
V
L
G
A
D
G
------
T
G
A
-----
K
----
E
L
Y
H
A
CVAPRLPDG
T
-------
S
------------
M
------------
K
--------
N
-------
R
L
-----------
Y
M
N
--------------
G
R
E
V
F
K
F
A
V
R
V
M
N
T
A
T
L
E
A
I
E
K
A
G
L
T
-
P
E
D
I
R
L
F
V
P
H
Q
A
N
L
R
I
I
D
A
A
R
E
R
L
G
L
-
P
W
E
-
R
V
--
A
V
-
N
V
D
R
Y
G
N
T
S
T
A
S
I
P
L
A
L
K
E
A
V
--
D
A
G
R
I
R
E
G
D
H
--
V
L
L
V
S
F
G
A
G
L
T
W
A
A
A
V
L
T
W
G
--
32
PsiBlast_CBE
83.19
44%
-121
- C2 -
2EFT
4
FABH_ECOLI
B:
[1-317]
M
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
-
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
-
P
N
E
T
V
----
S
T
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
-
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
-
A
S
E
E
P
G
I
I
S
T
H
L
H
A
D
G
------
S
Y
G
-----
E
----
L
L
T
-----------
L
P------
N
------------
A
------------
D
--------
R
VNPENSI
H
L
-----------
T
M
A
--------------
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
-
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
-
S
M
D
-
N
V
--
V
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
--
R
D
G
R
I
K
P
G
Q
L
--
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
---
10
PsiBlast_PDB
83.08
44%
-120
- C2 -
1HNJ
2
FABH_ECOLI
A:
[1-317]
M
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
-
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
-
P
N
E
T
V
----
S
T
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
-
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
-
A
S
E
E
P
G
I
I
S
T
H
L
H
A
D
G
------
S
Y
G
-----
E
----
L
L
T
-----------
L
P
------
N
------------
A
------------
D
--------
R
VNPENSI
H
L
-----------
T
M
A
--------------
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
-
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
-
S
M
D
-
N
V
--
V
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
--
R
D
G
R
I
K
P
G
Q
L
--
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
---
61
HHSearch
82.13
44%
-118
- C2 -
1HNJ
2
FABH_ECOLI
A:
[1-317]
M
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
-
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
-
P
N
E
T
V
----
S
T
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
-
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
S
E
E
-
P
G
I
I
S
T
H
L
H
A
D
G
------
S
Y
G
-----
E
----
L
L
T
-----------
L
-------
P
------------
N
------------
A
DRVNPENS
I
-------
H
L
-----------
T
M
A
--------------
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
-
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
-
S
M
D
-
N
V
--
V
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
--
R
D
G
R
I
K
P
G
Q
L
--
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
---
62
HHSearch
81.20
51%
-109
- C2 -
1UB7
4
?
A:
[2-321]
--
S
G
I
L
A
L
G
A
Y
V
P
E
R
V
M
T
N
A
D
F
E
A
Y
-
L
D
T
S
D
E
W
I
V
T
R
T
G
I
K
E
R
R
V
A
A
-
E
D
E
Y
T
----
S
D
L
A
F
K
A
V
E
D
L
L
R
R
H
P
G
A
L
E
G
V
D
A
V
I
V
A
T
N
T
P
D
A
L
F
P
D
T
A
A
L
V
Q
A
R
F
G
L
-
K
A
F
A
Y
D
L
L
A
G
C
P
G
W
I
Y
A
L
A
Q
A
H
A
L
V
E
A
G
L
A
Q
K
V
L
A
V
G
A
E
A
L
S
K
I
I
D
W
-
N
D
R
A
T
A
V
L
F
G
D
G
G
G
A
A
V
V
G
K
V
R
E
G
Y
G
F
R
S
F
V
L
G
A
D
G
------
T
G
A
-----
K
E
L
Y
H
A
C
V
APR--------
L
-------
P
------------
D
------------
G
TSMK----
N
-------
R
L
-----------
Y
M
N
--------------
G
R
E
V
F
K
F
A
V
R
V
M
N
T
A
T
L
E
A
I
E
K
A
G
L
T
-
P
E
D
I
R
L
F
V
P
H
Q
A
N
L
R
I
I
D
A
A
R
E
R
L
G
L
-
P
W
E
-
R
V
--
A
V
-
N
V
D
R
Y
G
N
T
S
T
A
S
I
P
L
A
L
K
E
A
V
--
D
A
G
R
I
R
E
G
D
H
--
V
L
L
V
S
F
G
A
G
L
T
W
A
A
A
V
L
T
W
G
G
-
16
PsiBlast_PDB
80.90
43%
-115
- C2 -
3IL9
-
FABH_ECOLI
A:
[1-317]
M
Y
T
K
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
-
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
-
P
N
E
T
V
----
S
T
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
K
G
C
P
A
F
D
V
A
A
A
-
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
S
G
A
V
K
Y
A
L
V
V
G
S
D
V
L
A
R
T
C
D
P
-
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
-
A
S
E
E
P
G
I
I
S
T
H
L
H
A
D
G
------
S
Y
G
-----
E
----
L
L
T
-----------
L
P
------
N
------------
A
------------
D
--------
R
VNPENSI
H
L
-----------
T
M
A
--------------
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
-
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
I
I
S
A
T
A
K
K
L
G
M
-
S
M
D
-
N
V
--
V
V
-
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
--
R
D
G
R
I
K
P
G
Q
L
--
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
---
5
PsiBlast_PDB
80.61
43%
-122
- C2 -
4WZU
1
FABH2_VIBCH
A:
[6-325]
--
A
E
I
T
G
W
G
K
C
L
P
P
A
T
L
S
N
H
D
L
S
T
F
-
L
D
T
S
D
E
W
I
Q
S
R
T
G
I
E
Q
R
R
I
S
---
H
V
N
T
----
S
D
L
A
T
V
A
A
Q
H
A
I
A
C
A
G
V
S
V
E
E
I
D
L
I
I
V
A
T
C
S
P
D
S
L
I
P
N
I
A
S
R
V
Q
Q
N
L
G
I
P
S
A
A
A
F
D
L
N
A
A
C
T
G
F
L
Y
G
L
E
T
A
T
R
L
M
Q
A
S
H
Y
R
H
A
L
V
I
G
A
E
R
L
S
F
Y
L
D
W
-
T
K
R
D
T
A
V
L
F
G
D
G
A
G
A
V
V
L
S
K
T
E
Q
K
V
G
L
Q
D
A
Q
I
G
C
D
A
------
Q
G
R
-----
D
----
I
L
A
-----------
V
--------------------
P
------------
K
--------
F
-------
G
T
-----------
A
M
D
RFDADNGY
W
A
F
D
F
V
G
K
E
I
F
K
R
A
V
R
G
M
G
A
A
A
Q
Q
V
L
A
R
S
G
L
S
-
T
E
E
I
D
V
V
I
P
H
Q
A
N
I
R
I
I
Q
T
L
C
D
L
A
G
I
-
A
Q
D
-
K
A
--
F
V
-
N
I
H
R
Y
G
N
T
S
A
A
T
V
P
I
A
L
C
E
A
L
--
E
Q
G
K
I
K
P
H
D
D
--
L
L
V
A
A
F
G
A
G
L
T
W
G
A
G
H
I
R
W
G
--
43
PsiBlast_CBE
79.26
37%
-115
- C2 -
2QO1
3
FABH_MYCTU
A:
[14-331]
---
G
L
L
S
V
G
A
Y
R
P
E
R
V
V
T
N
D
E
I
C
Q
H
-
I
D
S
S
D
E
W
I
Y
T
R
T
G
I
K
T
R
R
F
A
A
-
D
D
E
S
A
----
A
S
M
A
T
E
A
C
R
R
A
L
S
N
A
G
L
S
A
A
D
I
D
G
V
I
V
T
T
N
T
H
F
L
Q
T
P
P
A
A
P
M
V
A
A
S
L
G
A
K
G
I
L
G
F
D
L
S
A
G
C
A
G
F
G
Y
A
L
G
A
A
A
D
M
I
R
G
G
G
A
A
T
M
L
V
V
G
T
E
K
L
S
P
T
I
D
M
-
Y
D
R
G
N
C
F
I
F
A
D
G
A
A
A
V
V
V
G
E
-
T
P
F
Q
G
I
G
P
T
V
A
G
S
D
G
------
E
Q
A
-----
D
----
A
I
R
-----------
Q
-------
D
ID
W
I
T
F
A
Q
N
PS
G
P
------------
R
--------
P
-------
F
V
-----------
R
L
E
--------------
G
P
A
V
F
R
W
A
A
F
K
M
G
D
V
G
R
R
A
M
D
A
A
G
V
R
-
P
D
Q
I
D
V
F
V
P
H
Q
A
N
S
R
I
N
E
L
L
V
K
N
L
Q
L
R
P
D
A
-
V
V
--
A
N
-
D
I
E
H
T
G
N
T
S
A
A
S
I
P
L
A
M
A
E
L
L
--
T
T
G
A
A
K
P
G
D
L
--
A
L
L
I
G
Y
G
A
G
L
S
Y
A
A
Q
V
V
R
----
44
PsiBlast_CBE
78.83
37%
-116
- C2 -
2QNZ
3
FABH_MYCTU
B:
[14-331]
---
G
L
L
S
V
G
A
Y
R
P
E
R
V
V
T
N
D
E
I
C
------
S
D
E
W
I
Y
T
R
T
G
I
K
T
R
R
F
A
A
-
D
D
E
S
A
----
A
S
M
A
T
E
A
C
R
R
A
L
S
N
A
G
L
S
A
A
D
I
D
G
V
I
V
T
T
N
T
H
F
L
Q
T
P
P
A
A
P
M
V
A
A
S
L
G
A
K
G
I
L
G
F
D
L
S
A
G
C
A
G
F
G
Y
A
L
G
A
A
A
D
M
I
R
G
G
G
A
A
T
M
L
V
V
G
T
E
K
L
S
P
T
I
D
M
-
Y
D
R
G
N
C
F
I
F
A
D
G
A
A
A
V
V
V
G
E
-
T
P
F
Q
G
I
G
P
T
V
A
G
S
D
G
------
E
Q
A
-----
D
----
A
I
R
-----------
Q
-------
D
ID
W
I
T
F
A
Q
N
PS
G
P
------------
R
--------
P
-------
F
V
-----------
R
L
E
--------------
G
P
A
V
F
R
W
A
A
F
K
M
G
D
V
G
R
R
A
M
D
A
A
G
V
R
-
P
D
Q
I
D
V
F
V
P
H
Q
A
N
S
R
I
N
E
L
L
V
K
N
L
Q
L
R
P
D
A
-
V
V
--
A
N
-
D
I
E
H
T
G
N
T
S
A
A
S
I
P
L
A
M
A
E
L
L
--
T
T
G
A
A
K
P
G
D
L
--
A
L
L
I
G
Y
G
A
G
L
S
Y
A
A
Q
V
V
R
----
49
PsiBlast_CBE
78.74
37%
-116
- C2 -
1HZP
7
FABH_MYCTU
A:
[14-331]
---
G
L
L
S
V
G
A
Y
R
P
E
R
V
V
T
N
D
E
I
C
Q
H
-
I
D
S
S
D
E
W
I
Y
T
R
T
G
I
K
T
R
R
F
A
A
-
D
D
E
S
A
----
A
S
M
A
T
E
A
C
R
R
A
L
S
N
A
G
L
S
A
A
D
I
D
G
V
I
V
T
T
N
T
H
F
L
Q
T
P
P
A
A
P
M
V
A
A
S
L
G
A
K
G
I
L
G
F
D
L
S
A
G
C
A
G
F
G
Y
A
L
G
A
A
A
D
M
I
R
G
G
G
A
A
T
M
L
V
V
G
T
E
K
L
S
P
T
I
D
M
-
Y
D
R
G
N
C
F
I
F
A
D
G
A
A
A
V
V
V
G
E
-
T
P
F
Q
G
I
G
P
T
V
A
G
S
D
G
------
E
Q
A
-----
D
----
A
I
R
-----------
Q
-------
D
ID
W
I
T
F
A
Q
N
P
S
G
P
------------
R
--------
P
-------
F
V
-----------
R
L
E
--------------
G
P
A
V
F
R
W
A
A
F
K
M
G
D
V
G
R
R
A
M
D
A
A
G
V
R
-
P
D
Q
I
D
V
F
V
P
H
Q
A
N
S
R
I
N
E
L
L
V
K
N
L
Q
L
R
P
D
A
-
V
V
--
A
N
-
D
I
E
H
T
G
N
T
S
A
A
S
I
P
L
A
M
A
E
L
L
--
T
T
G
A
A
K
P
G
D
L
--
A
L
L
I
G
Y
G
A
G
L
S
Y
A
A
Q
V
V
R
----
47
PsiBlast_CBE
78.61
37%
-115
- C2 -
2QNX
3
FABH_MYCTU
A:
[14-331]
---
G
L
L
S
V
G
A
Y
R
P
E
R
V
V
T
N
D
E
I
C
Q
H
-
I
D
S
S
D
E
W
I
Y
T
R
T
G
I
K
T
R
R
F
A
A
-
D
D
E
S
A
----
A
S
M
A
T
E
A
C
R
R
A
L
S
N
A
G
L
S
A
A
D
I
D
G
V
I
V
T
T
N
T
H
F
L
Q
T
P
P
A
A
P
M
V
A
A
S
L
G
A
K
G
I
L
G
F
D
L
S
A
G
C
A
G
F
G
Y
A
L
G
A
A
A
D
M
I
R
G
G
G
A
A
T
M
L
V
V
G
T
E
K
L
S
P
T
I
D
M
-
Y
D
R
G
N
C
F
I
F
A
D
G
A
A
A
V
V
V
G
E
-
T
P
F
Q
G
I
G
P
T
V
A
G
S
D
G
------
E
Q
A
-----
D
----
A
I
R
-----------
Q
-------
D
ID
W
I
T
F
A
Q
N
PS
G
P
------------
R
--------
P
-------
F
V
-----------
R
L
E
--------------
G
P
A
V
F
R
W
A
A
F
K
M
G
D
V
G
R
R
A
M
D
A
A
G
V
R
-
P
D
Q
I
D
V
F
V
P
H
Q
A
N
S
R
I
N
E
L
L
V
K
N
L
Q
L
R
P
D
A
-
V
V
--
A
N
-
D
I
E
H
T
G
N
T
S
A
A
S
I
P
L
A
M
A
E
L
L
--
T
T
G
A
A
K
P
G
D
L
--
A
L
L
I
G
Y
G
A
G
L
S
Y
A
A
Q
V
V
R
----
48
PsiBlast_CBE
78.10
37%
-114
- C2 -
1HZP
2
FABH_MYCTU
B:
[14-331]
---
G
L
L
S
V
G
A
Y
R
P
E
R
V
V
T
N
D
E
I
C
Q
H
-
I
D
S
S
D
E
W
I
Y
T
R
T
G
I
K
T
R
R
F
A
A
-
D
D
E
S
A
----
A
S
M
A
T
E
A
C
R
R
A
L
S
N
A
G
L
S
A
A
D
I
D
G
V
I
V
T
T
N
T
H
F
L
Q
T
P
P
A
A
P
M
V
A
A
S
L
G
A
K
G
I
L
G
F
D
L
S
A
G
C
A
G
F
G
Y
A
L
G
A
A
A
D
M
I
R
G
G
G
A
A
T
M
L
V
V
G
T
E
K
L
S
P
T
I
D
M
-
Y
D
R
G
N
C
F
I
F
A
D
G
A
A
A
V
V
V
G
E
-
T
P
F
Q
G
I
G
P
T
V
A
G
S
D
G
------
E
Q
A
-----
D
----
A
I
R
-----------
Q
-------
D
IDWITFAQNPSG
P
------------
R
--------
P
-------
F
V
-----------
R
L
E
--------------
G
P
A
V
F
R
W
A
A
F
K
M
G
D
V
G
R
R
A
M
D
A
A
G
V
R
-
P
D
Q
I
D
V
F
V
P
H
Q
A
N
S
R
I
N
E
L
L
V
K
N
L
Q
L
R
P
D
A
-
V
V
--
A
N
-
D
I
E
H
T
G
N
T
S
A
A
S
I
P
L
A
M
A
E
L
L
--
T
T
G
A
A
K
P
G
D
L
--
A
L
L
I
G
Y
G
A
G
L
S
Y
A
A
Q
V
V
R
----
41
PsiBlast_CBE
77.64
37%
-115
- C2 -
2QX1
3
FABH_MYCTU
A:
[14-331]
---
G
L
L
S
V
G
A
Y
R
P
E
R
V
V
T
N
D
E
I
C
Q
H
-
I
D
S
S
D
E
W
I
Y
T
R
T
G
I
K
T
R
R
F
A
A
-
D
D
E
S
A
----
A
S
M
A
T
E
A
C
R
R
A
L
S
N
A
G
L
S
A
A
D
I
D
G
V
I
V
T
T
N
T
H
F
L
Q
T
P
P
A
A
P
M
V
A
A
S
L
G
A
K
G
I
L
G
F
D
L
S
A
G
C
A
G
F
G
Y
A
L
G
A
A
A
D
M
I
R
G
G
G
A
A
T
M
L
V
V
G
T
E
K
L
S
P
T
I
D
M
-
Y
D
R
G
N
C
F
I
F
A
D
G
A
A
A
V
V
V
G
E
-
T
P
F
Q
G
I
G
P
T
V
A
G
S
D
G
------
E
Q
A
-----
D
----
A
I
R
-----------
Q
-------
D
ID
W
I
T
F
A
Q
N
PS
G
P
------------
R
--------
P
-------
F
V
-----------
R
L
E
--------------
G
P
A
V
F
R
W
A
A
F
K
M
G
D
V
G
R
R
A
M
D
A
A
G
V
R
-
P
D
Q
I
D
V
F
V
P
H
Q
A
N
S
R
I
N
E
L
L
V
K
N
L
Q
L
R
P
D
A
-
V
V
--
A
N
-
D
I
E
H
T
G
N
T
S
A
A
S
I
P
L
A
M
A
E
L
L
--
T
T
G
A
A
K
P
G
D
L
--
A
L
L
I
G
Y
G
A
G
L
S
Y
A
A
Q
V
V
R
----
46
PsiBlast_CBE
76.15
37%
-111
- C2 -
2QNX
3
FABH_MYCTU
B:
[14-331]
---
G
L
L
S
V
G
A
Y
R
P
E
R
V
V
T
N
D
E
I
C
---
I
D
S
S
D
E
W
I
Y
T
R
T
G
I
K
T
R
R
F
A
A
-
D
D
E
S
A
----
A
S
M
A
T
E
A
C
R
R
A
L
S
N
A
G
L
S
A
A
D
I
D
G
V
I
V
T
T
N
T
H
F
L
Q
T
P
P
A
A
P
M
V
A
A
S
L
G
A
K
G
I
L
G
F
D
L
S
A
G
C
A
G
F
G
Y
A
L
G
A
A
A
D
M
I
R
G
G
G
A
A
T
M
L
V
V
G
T
E
K
L
S
P
T
I
D
M
-
Y
D
R
G
N
C
F
I
F
A
D
G
A
A
A
V
V
V
G
E
-
T
P
F
Q
G
I
G
P
T
V
A
G
S
D
G
------
E
Q
A
-----
D
----
A
I
R
-----------
Q
-------
D
ID
W
I
T
F
A
Q
N
PS
G
P
------------
R
--------
P
-------
F
V
-----------
R
L
E
--------------
G
P
A
V
F
R
W
A
A
F
K
M
G
D
V
G
R
R
A
M
D
A
A
G
V
R
-
P
D
Q
I
D
V
F
V
P
H
Q
A
N
S
R
I
N
E
L
L
V
K
N
L
Q
L
R
P
D
A
-
V
V
--
A
N
-
D
I
E
H
T
G
N
T
S
A
A
S
I
P
L
A
M
A
E
L
L
--
T
T
G
A
A
K
P
G
D
L
--
A
L
L
I
G
Y
G
A
G
L
S
Y
A
A
Q
V
V
R
----
42
PsiBlast_CBE
75.49
37%
-112
- C2 -
2QO1
3
FABH_MYCTU
B:
[14-331]
---
G
L
L
S
V
G
A
Y
R
P
E
R
V
V
T
N
D
E
I
C
Q
H
-
I
D
S
S
D
E
W
I
Y
T
R
T
G
I
K
T
R
R
F
A
A
-
D
D
E
S
A
----
A
S
M
A
T
E
A
C
R
R
A
L
S
N
A
G
L
S
A
A
D
I
D
G
V
I
V
T
T
N
T
H
F
L
Q
T
P
P
A
A
P
M
V
A
A
S
L
G
A
K
G
I
L
G
F
D
L
S
A
G
C
A
G
F
G
Y
A
L
G
A
A
A
D
M
I
R
G
G
G
A
A
T
M
L
V
V
G
T
E
K
L
S
P
T
I
D
M
-
Y
D
R
G
N
C
F
I
F
A
D
G
A
A
A
V
V
V
G
E
-
T
P
F
Q
G
I
G
P
T
V
A
G
S
D
G
------
E
Q
A
-----
D
----
A
I
R
-----------
Q
-------
D
IDWITFAQNPSG
P
------------
R
--------
P
-------
F
V
-----------
R
L
E
--------------
G
P
A
V
F
R
W
A
A
F
K
M
G
D
V
G
R
R
A
M
D
A
A
G
V
R
-
P
D
Q
I
D
V
F
V
P
H
Q
A
N
S
R
I
N
E
L
L
V
K
N
L
Q
L
R
P
D
A
-
V
V
--
A
N
-
D
I
E
H
T
G
N
T
S
A
A
S
I
P
L
A
M
A
E
L
L
--
T
T
G
A
A
K
P
G
D
L
--
A
L
L
I
G
Y
G
A
G
L
S
Y
A
A
Q
V
V
R
----
34
PsiBlast_CBE
75.48
42%
-116
- C2 -
3IL5
1
FABH_ENTFA
D:
[25-339]
--
A
R
I
S
C
T
S
R
Y
V
P
E
N
C
V
T
N
H
Q
L
S
E
M
-
M
D
T
S
D
E
W
I
H
S
R
T
G
I
S
E
R
R
I
V
T
-
Q
E
N
-
T
----
S
D
L
C
H
Q
V
A
K
Q
L
L
E
K
S
G
K
Q
A
S
E
I
D
F
I
L
V
A
T
V
T
P
D
F
N
M
P
S
V
A
C
Q
V
Q
G
A
I
G
A
T
E
A
F
A
F
D
I
S
A
A
C
S
G
F
V
Y
A
L
S
M
A
E
K
L
V
L
S
G
R
Y
Q
T
G
L
V
I
G
G
E
T
F
S
K
M
L
D
W
-
T
D
R
S
T
A
V
L
F
G
D
G
A
-
A
G
V
L
I
E
A
A
E
T
P
H
F
L
N
E
K
L
Q
A
D
G
QRWAAL
T
S
G
YTINE
S
----
P
F
Y
-----------
Q
-------
G
------------
H
------------
K
--------
Q
-------
A
S
KTL--------
Q
M
E
--------------
G
R
S
I
F
D
F
A
I
K
D
V
S
Q
N
I
L
S
L
V
-----
T
-
D
E
T
V
D
Y
L
L
L
H
Q
A
N
V
R
I
I
D
K
I
A
R
K
T
K
I
-
S
R
E
-
K
F
--
L
T
-
N
M
D
K
Y
G
N
T
S
A
A
S
I
P
I
L
L
D
E
A
V
--
E
N
G
T
L
I
L
G
S
Q
QR
V
V
L
T
G
F
G
G
G
L
T
W
G
S
L
L
L
-----
39
PsiBlast_CBE
75.05
38%
-114
- C2 -
1MZJ
2
FABH_STRLI
A:
[14-329]
----
V
L
G
V
G
S
Y
R
P
R
R
E
V
S
N
K
E
V
C
T
W
-
I
D
S
T
E
E
W
I
E
T
R
T
G
I
R
S
R
R
I
A
E
-
P
D
E
T
I
----
Q
V
M
G
V
A
A
S
R
R
A
L
E
H
A
G
V
D
P
A
E
I
D
L
V
V
V
S
T
M
T
N
F
V
H
T
P
P
L
S
V
A
I
A
H
E
L
G
A
D
N
A
G
G
F
D
L
S
A
A
C
A
G
F
C
H
A
L
S
I
A
A
D
A
V
E
S
G
G
S
R
H
V
L
V
V
A
T
E
R
M
T
D
V
I
D
L
-
A
D
R
S
L
S
F
L
F
G
D
G
A
G
A
A
V
V
G
P
-
S
D
V
P
G
I
G
P
V
V
R
G
I
D
G
------
T
G
L
-----
G
----
S
L
H
-----------
M
-------
S
------------
S
S
W
D
Q
Y
V
E
DPSVG
R
--------
P
-------
A
L
-----------
V
M
D
--------------
G
K
R
V
F
R
W
A
V
A
D
V
V
P
A
A
R
E
A
L
E
V
A
G
L
T
-
V
G
D
L
V
A
F
V
P
H
Q
A
N
L
R
I
I
D
V
L
V
D
R
L
G
V
-
P
E
H
V
V
V
--
S
R
-
D
A
E
D
T
G
N
T
S
S
A
S
V
A
L
A
L
D
R
L
V
--
R
S
G
A
V
P
G
G
G
P
--
A
L
M
I
G
F
G
A
G
L
S
Y
A
G
Q
A
L
-----
38
PsiBlast_CBE
75.05
38%
-116
- C2 -
1MZJ
2
FABH_STRLI
B:
[14-329]
----
V
L
G
V
G
S
Y
R
P
R
R
E
V
S
N
K
E
V
C
T
W
-
I
D
S
T
E
E
W
I
E
T
R
T
G
I
R
S
R
R
I
A
E
-
P
D
E
T
I
----
Q
V
M
G
V
A
A
S
R
R
A
L
E
H
A
G
V
D
P
A
E
I
D
L
V
V
V
S
T
M
T
N
F
V
H
T
P
P
L
S
V
A
I
A
H
E
L
G
A
D
N
A
G
G
F
D
L
S
A
A
C
A
G
F
C
H
A
L
S
I
A
A
D
A
V
E
S
G
G
S
R
H
V
L
V
V
A
T
E
R
M
T
D
V
I
D
L
-
A
D
R
S
L
S
F
L
F
G
D
G
A
G
A
A
V
V
G
P
-
S
D
V
P
G
I
G
P
V
V
R
G
I
D
G
------
T
G
L
-----
G
----
S
L
H
-----------
M
-------
S
------------
S
S
W
D
Q
Y
V
EDPSVG
R
--------
P
-------
A
L
-----------
V
M
D
--------------
G
K
R
V
F
R
W
A
V
A
D
V
V
P
A
A
R
E
A
L
E
V
A
G
L
T
-
V
G
D
L
V
A
F
V
P
H
Q
A
N
L
R
I
I
D
V
L
V
D
R
L
G
V
-
P
E
H
V
V
V
--
S
R
-
D
A
E
D
T
G
N
T
S
S
A
S
V
A
L
A
L
D
R
L
V
--
R
S
G
A
V
P
G
G
G
P
--
A
L
M
I
G
F
G
A
G
L
S
Y
A
G
Q
A
L
-----
37
PsiBlast_CBE
74.91
42%
-114
- C2 -
3IL5
1
FABH_ENTFA
A:
[25-339]
--
A
R
I
S
C
T
S
R
Y
V
P
E
N
C
V
T
N
H
Q
L
S
E
M
-
M
D
T
S
D
E
W
I
H
S
R
T
G
I
S
E
R
R
I
V
T
-
Q
E
N
-
T
----
S
D
L
C
H
Q
V
A
K
Q
L
L
E
K
S
G
K
Q
A
S
E
I
D
F
I
L
V
A
T
V
T
P
D
F
N
M
P
S
V
A
C
Q
V
Q
G
A
I
G
A
T
E
A
F
A
F
D
I
S
A
A
C
S
G
F
V
Y
A
L
S
M
A
E
K
L
V
L
S
G
R
Y
Q
T
G
L
V
I
G
G
E
T
F
S
K
M
L
D
W
-
T
D
R
S
T
A
V
L
F
G
D
G
A
-
A
G
V
L
I
E
A
A
E
T
P
H
F
L
N
E
K
L
Q
A
D
G
QRWAAL
T
S
G
Y
T
I
N
E
S
----
P
F
Y
-----------
Q
-------
G
------------
H
------------
K
--------
Q
-------
A
S
KTL--------
Q
M
E
--------------
G
R
S
I
F
D
F
A
I
K
D
V
S
Q
N
I
L
S
L
V
-----
T
-
D
E
T
V
D
Y
L
L
L
H
Q
A
N
V
R
I
I
D
K
I
A
R
K
T
K
I
-
S
R
E
-
K
F
--
L
T
-
N
M
D
K
Y
G
N
T
S
A
A
S
I
P
I
L
L
D
E
A
V
--
E
N
G
T
L
I
L
G
S
Q
QR
V
V
L
T
G
F
G
G
G
L
T
W
G
S
L
L
L
-----
54
PsiBlast_CBE
74.86
36%
-111
- C2 -
1U6S
2
FABH_MYCTU
B:
[14-331]
---
G
L
L
S
V
G
A
Y
R
P
E
R
V
V
T
N
D
E
I
C
Q
H
-
I
D
S
S
D
E
W
I
Y
T
R
T
G
I
K
T
R
R
F
A
A
-
D
D
E
S
A
----
A
S
M
A
T
E
A
C
R
R
A
L
S
N
A
G
L
S
A
A
D
I
D
G
V
I
V
T
T
N
T
H
F
L
Q
T
P
P
A
A
P
M
V
A
A
S
L
G
A
K
G
I
L
G
F
D
L
S
A
G
A
A
G
F
G
Y
A
L
G
A
A
A
D
M
I
R
G
G
G
A
A
T
M
L
V
V
G
T
E
K
L
S
P
T
I
D
M
-
Y
D
R
G
N
C
F
I
F
A
D
G
A
A
A
V
V
V
G
E
-
T
P
F
Q
G
I
G
P
T
V
A
G
S
D
G
------
E
Q
A
-----
D
----
A
I
R
-----------
Q
-------
D
IDWITFAQNPSG
P
------------
R
--------
P
-------
F
V
-----------
R
L
E
--------------
G
P
A
V
F
R
W
A
A
F
K
M
G
D
V
G
R
R
A
M
D
A
A
G
V
R
-
P
D
Q
I
D
V
F
V
P
H
Q
A
N
S
R
I
N
E
L
L
V
K
N
L
Q
L
R
P
D
A
-
V
V
--
A
N
-
D
I
E
H
T
G
N
T
S
A
A
S
I
P
L
A
M
A
E
L
L
--
T
T
G
A
A
K
P
G
D
L
--
A
L
L
I
G
Y
G
A
G
L
S
Y
A
A
Q
V
V
R
----
55
PsiBlast_CBE
74.53
36%
-113
- C2 -
1U6S
2
FABH_MYCTU
A:
[14-331]
---
G
L
L
S
V
G
A
Y
R
P
E
R
V
V
T
N
D
E
I
C
Q
H
-
I
D
S
S
D
E
W
I
Y
T
R
T
G
I
K
T
R
R
F
A
A
-
D
D
E
S
A
----
A
S
M
A
T
E
A
C
R
R
A
L
S
N
A
G
L
S
A
A
D
I
D
G
V
I
V
T
T
N
T
H
F
L
Q
T
P
P
A
A
P
M
V
A
A
S
L
G
A
K
G
I
L
G
F
D
L
S
A
G
A
A
G
F
G
Y
A
L
G
A
A
A
D
M
I
R
G
G
G
A
A
T
M
L
V
V
G
T
E
K
L
S
P
T
I
D
M
-
Y
D
R
G
N
C
F
I
F
A
D
G
A
A
A
V
V
V
G
E
-
T
P
F
Q
G
I
G
P
T
V
A
G
S
D
G
------
E
Q
A
-----
D
----
A
I
R
-----------
Q
-------
D
ID
W
I
T
F
A
Q
N
PS
G
P
------------
R
--------
P
-------
F
V
-----------
R
L
E
--------------
G
P
A
V
F
R
W
A
A
F
K
M
G
D
V
G
R
R
A
M
D
A
A
G
V
R
-
P
D
Q
I
D
V
F
V
P
H
Q
A
N
S
R
I
N
E
L
L
V
K
N
L
Q
L
R
P
D
A
-
V
V
--
A
N
-
D
I
E
H
T
G
N
T
S
A
A
S
I
P
L
A
M
A
E
L
L
--
T
T
G
A
A
K
P
G
D
L
--
A
L
L
I
G
Y
G
A
G
L
S
Y
A
A
Q
V
V
R
----
71
HHSearch
73.86
38%
-112
- C2 -
1MZJ
2
FABH_STRLI
A:
[11-332]
-
F
S
R
V
L
G
V
G
S
Y
R
P
R
R
E
V
S
N
K
E
V
C
T
W
-
I
D
S
T
E
E
W
I
E
T
R
T
G
I
R
S
R
R
I
A
E
-
P
D
E
T
I
----
Q
V
M
G
V
A
A
S
R
R
A
L
E
H
A
G
V
D
P
A
E
I
D
L
V
V
V
S
T
M
T
N
F
V
H
T
P
P
L
S
V
A
I
A
H
E
L
G
A
D
N
A
G
G
F
D
L
S
A
A
C
A
G
F
C
H
A
L
S
I
A
A
D
A
V
E
S
G
G
S
R
H
V
L
V
V
A
T
E
R
M
T
D
V
I
D
L
-
A
D
R
S
L
S
F
L
F
G
D
G
A
G
A
A
V
V
G
P
S
D
V
P
-
G
I
G
P
V
V
R
G
I
D
G
------
T
G
L
-----
G
----
S
L
H
-----------
M
SSS
W
D
Q
Y
V
E
DPSV-------
G
------------
R
--------
P
-------
A
L
-----------
V
M
D
--------------
G
K
R
V
F
R
W
A
V
A
D
V
V
P
A
A
R
E
A
L
E
V
A
G
L
T
-
V
G
D
L
V
A
F
V
P
H
Q
A
N
L
R
I
I
D
V
L
V
D
R
L
G
V
-
P
E
H
-
V
V
--
V
S
R
D
A
E
D
T
G
N
T
S
S
A
S
V
A
L
A
L
D
R
L
V
--
R
S
G
A
V
P
G
G
G
P
--
A
L
M
I
G
F
G
A
G
L
S
Y
A
G
Q
A
L
L
L
P
--
35
PsiBlast_CBE
72.34
42%
-109
- C2 -
3IL5
1
FABH_ENTFA
C:
[25-339]
--
A
R
I
S
C
T
S
R
Y
V
P
E
N
C
V
T
N
H
Q
L
S
E
M
-
M
D
T
S
D
E
W
I
H
S
R
T
G
I
S
E
R
R
I
V
T
-
Q
E
N
-
T
----
S
D
L
C
H
Q
V
A
K
Q
L
L
E
K
S
G
K
Q
A
S
E
I
D
F
I
L
V
A
T
V
T
P
D
F
N
M
P
S
V
A
C
Q
V
Q
G
A
I
G
A
T
E
A
F
A
F
D
I
S
A
A
C
S
G
F
V
Y
A
L
S
M
A
E
K
L
V
L
S
G
R
Y
Q
T
G
L
V
I
G
G
E
T
F
S
K
M
L
D
W
-
T
D
R
S
T
A
V
L
F
G
D
G
A
-
A
G
V
L
I
E
A
A
E
T
P
H
F
L
N
E
K
L
Q
A
D
G
QRWAAL
T
S
G
YTINE
S
----
P
F
Y
-----------
Q
-------
G
------------
H
------------
K
--------
Q
-------
A
S
KTL--------
Q
M
E
--------------
G
R
S
I
F
D
F
A
I
K
D
V
S
Q
N
I
L
S
L
V
-----
T
-
D
E
T
V
D
Y
L
L
L
H
Q
A
N
V
R
I
I
D
K
I
A
R
K
T
K
I
-
S
R
E
-
K
F
--
L
T
-
N
M
D
K
Y
G
N
T
S
A
A
S
I
P
I
L
L
D
E
A
V
--
E
N
G
T
L
I
L
G
S
Q
QR
V
V
L
T
G
F
G
G
G
L
T
W
G
S
L
L
L
-----
36
PsiBlast_CBE
71.38
42%
-112
- C2 -
3IL5
1
FABH_ENTFA
B:
[25-339]
--
A
R
I
S
C
T
S
R
Y
V
P
E
N
C
V
T
N
H
Q
L
S
E
M
-
M
D
T
-
D
E
W
I
H
S
R
T
G
I
S
E
R
R
I
V
T
-
Q
E
N
-
T
----
S
D
L
C
H
Q
V
A
K
Q
L
L
E
K
S
G
K
Q
A
S
E
I
D
F
I
L
V
A
T
V
T
P
D
F
N
M
P
S
V
A
C
Q
V
Q
G
A
I
G
A
T
E
A
F
A
F
D
I
S
A
A
C
S
G
F
V
Y
A
L
S
M
A
E
K
L
V
L
S
G
R
Y
Q
T
G
L
V
I
G
G
E
T
F
S
K
M
L
D
W
-
T
D
R
S
T
A
V
L
F
G
D
G
A
-
A
G
V
L
I
E
A
A
E
T
P
H
F
L
N
E
K
L
Q
A
D
G
QRWAAL
T
S
G
Y
T
I
N
E
S
----
P
F
Y
-----------
Q
-------
G
------------
H
------------
K
--------
Q
-------
A
S
KTL--------
Q
M
E
--------------
G
R
S
I
F
D
F
A
I
K
D
V
S
Q
N
I
L
S
L
V
-----
T
-
D
E
T
V
D
Y
L
L
L
H
Q
A
N
V
R
I
I
D
K
I
A
R
K
T
K
I
-
S
R
E
-
K
F
--
L
T
-
N
M
D
K
Y
G
N
T
S
A
A
S
I
P
I
L
L
D
E
A
V
--
E
N
G
T
L
I
L
G
S
Q
Q
R
V
V
L
T
G
F
G
G
G
L
T
W
G
S
L
L
L
-----