@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu12330: (2016-06-19 )
MKAVQVRKAYDLVTAEVKKPVLSKDDEVLVKVKRVGICGSDMHIYHGTNPLATLPRVIGHEVTGQVEAVGANVQSLKPGDHVVIEPISYCGSCYACRKGRPNVCAKLSVFGVHEDGGMREYIVLPERQLHAVSKDLPWEEAVMAEPYTIGAQAVWRGQVEKGDTVLIQGAGPIGICVLKMAKLAGAAVMMTDLNNERLAFAKENGADAVVNVQAEHVAERVLEWTGNEGANVVIDAVCLPETFALSIEAVSPAGHVVVLGFDERAAQISQLPITKKEVTITGSRLQTNQFPKVVELLNGGRLMHNGLVTHTFSVDDVHHAFQFIKEHPDQVRKAVITFD
Atome Classification :
(23 SA)
....-.....-10-.........20........30........40.-...-..---.-.50--.-...---.-....60........70........80........90........100.......110-----.-.-.....120...--....130.......140..-.....150.......160.......170.......180--....-.-..190.......200.......210---.-----.----......220...--.--...230.......240.......250.......260------...--...--.270-.---...---.-..-.--280....-.-.------.290.-.......300.......310-.......320.......330.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MK
A
V
-
Q
V
R
K
A
-
Y
--
D
L
V
T
A
E
VKKPVLSKDD
E
V
L
V
K
V
K
R
VGICGS
D
M
-
H
I
Y-HG---T-
N
P
---
L
-
A
T
L
---
P
-
R
V
I
G
HEVTGQ
V
E
AVGANVQSLKPG
D
H
V
V
I
E
P
I
S
YCGS
C
Y
A
CRKGRPN
V
C
A
K
L
S
V
F
G
V-----H-E-DGG
M
R
E
Y
I
VL
P
--
E
R
Q
L
H
A
V
SKDLPW
E
E
A
VMA-EPYTIGA
Q
A
V
WRGQVEKG
D
T
V
L
I
QGAG
P
I
G
I
C
V
L
K
M
A
K
--LAG
A
-
A
-
V
M
M
TDLNNE
R
L
A
F
AKENGA
D
A
V
V
N
----
V
-----
Q
----
A
E
H
V
A
E
R
V
L
E
WT--G--NEG
A
N
V
V
I
D
A
VCLP
E
T
F
A
L
S
I
E
A
VSPA
G
H
V
V
V
L
GF
D
------
E
R
A
--
A
Q
I
--SQ-L-P---IT
K
---
K
-
E
V
-
T
--
I
TGSRLQ-T-N------Q
F
-
P
K
-
V
V
E
L
LNG
G
R
L
M
HNG
L
V
T
H
T
F
-
S
V
D
D
V
H
H
A
F
Q
F
I
K
EH
P
D
Q
V
R
K
A
VITFD
21
PsiBlast_CBE
86.31
39%
-115
- C1 -
4ILK
3
?
B:
[21-357]
M
K
S
I
-
L
I
E
K
P
-
N
--
Q
L
S
I
I
E
R
E
I
P
T
P
S
A
G
-
E
V
R
V
K
V
K
L
A
G
I
C
G
S
D
S
-
H
I
Y
-
R
G
---
H
-
N
-------
K
Y
---
P
-
R
V
I
G
H
E
F
F
G
V
I
D
A
V
G
E
G
V
E
S
A
R
V
G
E
R
V
A
V
D
P
V
V
S
C
G
H
C
Y
P
C
S
I
G
K
P
N
V
C
T
T
L
A
V
L
G
V
-----
H
-
A
-
D
G
G
F
S
E
Y
A
V
V
P
--
A
K
N
A
W
K
I
P
E
A
V
A
D
Q
Y
A
V
M
I
-
E
P
F
T
I
A
A
N
V
T
G
H
G
Q
P
T
E
N
D
T
V
L
V
Y
G
A
G
P
I
G
L
T
I
V
Q
V
L
K
GV
Y
N
V
K
-
N
-
V
I
V
A
D
R
I
D
E
R
L
E
K
A
K
E
S
G
A
D
W
A
I
N
----
N
-----
S
QTPL
G
E
S
F
A
E
K
G
I
K
P
T
----------
L
I
I
D
A
A
C
H
P
S
I
L
K
E
A
V
T
L
A
S
P
A
A
R
I
V
L
M
G
F
S
------
S
E
P
--
S
E
V
--
I
Q
-
Q
-
G
---
I
T
G
---
K
-
E
L
-
S
--
I
F
S
S
R
L
N
-
A
-
N
------
K
F
-
P
V
-
V
I
D
W
L
S
K
G
L
I
K
P
E
K
L
I
T
H
T
F
-
D
F
Q
H
V
A
D
A
I
S
L
F
E
L
D
Q
K
H
C
C
K
V
L
L
T
F
-
1
PsiBlast_PDB
85.85
39%
-115
- C1 -
4ILK
3
?
A:
[21-357]
M
K
S
I
-
L
I
E
K
P
-
N
--
Q
L
S
I
I
E
R
E
I
P
T
P
S
A
G
-
E
V
R
V
K
V
K
L
A
G
I
C
G
S
D
S
-
H
I
Y
-
R
G
---
H
-
N
P
-------
Y
---
P
-
R
V
I
G
H
E
F
F
G
V
I
D
A
V
G
E
G
V
E
S
A
R
V
G
E
R
V
A
V
D
P
V
V
S
C
G
H
C
Y
P
C
S
I
G
K
P
N
V
C
T
T
L
A
V
L
G
V
-----
H
-
A
-
D
G
G
F
S
E
Y
A
V
V
P
--
A
K
N
A
W
K
I
P
E
A
V
A
D
Q
Y
A
V
M
I
-
E
P
F
T
I
A
A
N
V
T
G
H
G
Q
P
T
E
N
D
T
V
L
V
Y
G
A
G
P
I
G
L
T
I
V
Q
V
L
K
GV
Y
N
V
K
-
N
-
V
I
V
A
D
R
I
D
E
R
L
E
K
A
K
E
S
G
A
D
W
A
I
N
----
N
-----
S
QTP
L
G
E
S
F
A
E
K
G
I
K
P
T
----------
L
I
I
D
A
A
C
H
P
S
I
L
K
E
A
V
T
L
A
S
P
A
A
R
I
V
L
M
G
F
S
------
S
E
P
--
S
E
V
--
I
Q
-
Q
-
G
---
I
T
G
---
K
-
E
L
-
S
--
I
F
S
S
R
L
N
-
A
-
N
------
K
F
-
P
V
-
V
I
D
W
L
S
K
G
L
I
K
P
E
K
L
I
T
H
T
F
-
D
F
Q
H
V
A
D
A
I
S
L
F
E
L
D
Q
K
H
C
C
K
V
L
L
T
F
-
60
HHSearch
81.06
34%
-119
- C1 -
2D8A
6
TDH_PYRHO
A:
[5-347]
M
V
A
I
-
M
K
T
K
P
-
G
Y-
G
A
E
L
V
E
V
D
V
P
K
-
P
G
P
G
E
V
L
I
K
V
L
A
T
S
I
C
G
T
D
L
-
H
I
Y
-
E
W
---
N
-
E
W
A
Q
S
R
-
I
K
P
---
P
-
Q
I
M
G
H
E
V
A
G
E
V
V
E
I
G
P
G
V
E
G
I
E
V
G
D
Y
V
S
V
E
T
H
I
V
C
G
K
C
Y
------------
T
K
I
F
G
V
-----
D
-
T
-
D
G
V
F
A
E
Y
A
V
V
P
--
A
Q
N
I
W
K
N
P
K
S
I
P
P
E
Y
A
T
L
Q
-
E
P
L
G
N
A
V
D
T
V
L
-
A
G
P
I
S
G
K
S
V
L
I
T
G
A
G
P
L
G
L
L
G
I
A
V
A
K
--
A
S
G
A
-
Y
P
V
I
V
S
E
P
S
D
F
R
R
E
L
A
K
K
V
G
A
D
Y
V
I
N
----
P
-----
F
----
E
E
D
V
V
K
E
V
M
D
I
T
--
D
--
G
N
G
V
D
V
F
L
E
F
S
G
A
P
K
A
L
E
Q
G
L
Q
A
V
T
P
A
G
R
V
S
L
L
G
L
Y
------
P
G
K
--
V
T
I
--
D
F
-
N
N
L
---
I
I
F
---
K
-
A
L
-
T
--
I
Y
G
I
T
G
R
H
L
-
W
------
E
T
-
W
Y
T
V
S
R
L
L
Q
S
G
K
L
N
L
D
P
I
I
T
H
K
Y
K
G
F
D
K
Y
E
E
A
F
E
L
M
R
A
G
--
K
T
G
K
V
V
F
M
L
-
4
PsiBlast_PDB
78.42
32%
-124
- C1 -
1E3J
4
?
A:
[27-348]
---------------------------
K
E
D
E
V
L
L
Q
M
A
Y
V
G
I
C
G
S
D
V
-
H
Y
Y
E
H
G
RI-
A
-
D
F
---
I
-
V
K
D
---
P
-
M
V
I
G
H
E
A
S
G
T
V
V
K
V
G
K
N
V
K
H
L
K
K
G
D
R
V
A
V
E
P
G
V
P
C
R
R
C
Q
F
C
K
E
G
K
Y
N
L
C
P
D
L
T
F
C
A
T
-----
P
P
D
-
D
G
N
L
A
R
Y
Y
V
H
A
--
A
D
F
C
H
K
L
P
D
N
V
S
L
E
E
G
A
L
L
-
E
P
L
S
V
G
V
H
A
C
R
R
A
G
V
Q
L
G
T
T
V
L
V
I
G
A
G
P
I
G
L
V
S
V
L
A
A
K
--
A
Y
G
A
-
F
-
V
V
C
T
A
R
S
P
R
R
L
E
V
A
K
N
C
G
A
D
V
T
L
V
----
V
DPAKE
E
----
E
S
S
I
I
E
R
I
R
S
A
I
--
G
--
D
L
-
P
N
V
T
I
D
C
S
G
N
E
K
C
I
T
I
G
I
N
I
T
R
T
G
G
T
L
M
L
V
G
M
G
------
S
Q
M
--
V
T
V
--
P
L
-
V
-
N
---
A
C
A
---
R
-
E
I
-
D
--
I
K
S
V
F
R
Y
-
C
-
N
------
D
Y
-
P
I
-
A
L
E
M
V
A
S
G
R
C
N
V
K
Q
L
V
T
H
S
F
-
K
L
E
Q
T
V
D
A
F
E
A
A
R
K
K
A
D
N
T
I
K
V
M
I
S
--
22
PsiBlast_CBE
76.84
34%
-113
- C1 -
3GFB
4
TDH_THEKO
D:
[5-336]
M
Q
A
I
M
K
T
K
P
A
-
Y
GA
E
L
V
E
V
D
V
P
K
P
---
G
P
G
E
V
L
I
K
V
L
A
T
S
I
C
G
T
D
L
-
H
I
Y
-
E
W
---
N
-
E
W
---
A
-
Q
S
R
IKP
P
-
Q
I
M
G
H
E
V
A
G
E
V
V
E
V
G
P
G
V
E
D
L
Q
V
G
D
Y
I
S
V
E
T
H
I
V
C
G
K
C
Y
A
C
K
H
N
R
Y
H
V
C
Q
N
T
K
I
F
G
V
-----
D
-
M
-
D
G
V
F
A
H
Y
A
I
V
P
--
A
K
N
A
W
K
N
P
K
D
M
P
P
E
Y
A
A
L
Q
-
E
P
L
G
N
A
V
D
T
V
L
A
G
P
I
-
A
G
R
S
T
L
I
T
G
A
G
P
L
G
L
L
G
I
A
V
A
K
--
A
S
G
A
Y
P
-
V
I
V
S
E
P
S
E
F
R
R
K
L
A
K
K
V
G
A
D
Y
V
V
N
----
P
-----
F
----
E
E
D
P
V
K
F
V
M
D
I
T
--
D
--
G
A
G
V
E
V
F
L
E
F
S
G
A
P
K
A
L
E
Q
G
L
K
A
V
T
P
G
G
R
V
S
L
L
G
L
F
------
P
R
E
--
V
T
I
DF
N
N
-
L
-
I
---
I
F
K
---
A
L
E
V
H
G
--
I
T
G
R
H
L
W
-
E
-
T
------
W
Y
--
T
-
V
S
S
L
I
Q
S
G
K
L
N
L
D
P
I
I
T
H
K
Y
K
G
F
D
K
F
E
E
A
F
E
L
M
R
--------------
66
HHSearch
75.75
30%
-123
- C1 -
4EJ6
19
?
A:
[24-362]
M
K
A
V
-
R
L
E
S
V
-
G
--
N
I
S
V
R
N
V
G
I
P
E
-
P
G
P
D
D
L
L
V
K
V
E
A
C
G
I
C
G
T
D
R
-
H
L
L
-
H
G
---
E
-
F
P
-----
S
T
P
---
P
-
V
T
L
G
H
E
F
C
G
I
V
V
E
A
G
S
A
V
R
D
I
A
P
G
A
R
I
T
G
D
P
N
I
S
C
G
R
C
P
Q
C
Q
A
G
R
V
N
L
C
R
N
L
R
A
I
G
I
-----
H
-
R
-
D
G
G
F
A
E
Y
V
L
V
P
--
R
K
Q
A
F
E
I
P
L
T
L
D
P
V
H
G
A
F
C
-
E
P
L
A
C
C
L
H
G
V
D
L
S
G
I
K
A
G
S
T
V
A
I
L
G
G
G
V
I
G
L
L
T
V
Q
L
A
R
--
L
A
G
A
T
T
-
V
I
L
S
T
R
Q
A
T
K
R
R
L
A
E
E
V
G
A
T
A
T
V
D
----
P
-----
S
----
A
G
D
V
V
E
A
I
A
G
P
V
GL
V
--
P
G
G
V
D
V
V
I
E
C
A
G
V
A
E
T
V
K
Q
S
T
R
L
A
K
A
G
G
T
V
V
I
L
G
V
L
------
P
Q
G
E
K
V
E
I
--
E
P
-
F
-
D
---
I
L
F
---
R
-
E
L
-
R
--
V
L
G
S
F
I
N
---
P
------
F
V
-
H
R
R
A
A
D
L
V
A
T
G
A
I
E
I
D
R
M
I
S
R
R
I
-
S
L
D
E
A
P
D
V
I
S
N
P
A
A
A
--
G
E
V
K
V
L
V
I
P
-
7
PsiBlast_PDB
75.23
32%
-119
- C1 -
4CPD
3
?
A:
[1-333]
M
R
A
V
-
V
F
E
N
K
-
E
--
R
V
A
V
K
E
V
N
A
P
R
L
Q
H
P
L
D
A
L
V
R
V
H
L
A
G
I
C
G
S
D
L
-
H
L
Y
-
H
G
---
K
-
I
P
---
V
---
L
---
P
G
S
V
L
G
H
E
F
V
G
Q
V
E
A
V
G
E
G
I
Q
D
L
Q
P
G
D
W
V
V
G
P
F
H
I
A
C
G
T
C
P
Y
C
R
R
H
Q
Y
N
L
C
E
R
G
G
V
Y
G
Y
GPMFG
N
-
L
-
Q
G
A
Q
A
E
I
L
R
V
P
F
S
N
V
N
L
R
K
L
P
P
N
L
S
P
E
R
A
I
F
A
G
D
I
L
S
T
A
Y
G
G
L
I
Q
G
Q
L
R
P
G
D
S
V
A
V
I
G
A
G
P
V
G
L
M
A
I
E
V
A
Q
--
V
L
G
A
-
S
K
I
L
A
I
D
R
I
P
E
R
L
E
R
A
A
S
L
G
A
I
P
-
I
N
----
A
-----
E
----
Q
E
N
P
V
R
R
V
R
S
E
T
--
N
--
D
E
G
P
D
L
V
L
E
A
V
G
G
A
A
T
L
S
L
A
L
E
M
V
R
P
G
G
R
V
S
A
V
G
V
D
------
N
----
A
P
S
--
F
P
-
F
-
P
---
L
A
S
G
L
V
K
-
D
L
-
T
--
F
R
I
G
L
A
N
-
V
-
H
------
L
Y
I
D
A
-
V
L
A
L
L
A
S
G
R
L
Q
P
E
R
I
V
S
H
Y
L
-
P
L
E
E
A
P
R
G
Y
E
L
F
---------------
27
PsiBlast_CBE
74.72
32%
-119
- C1 -
4CPD
3
?
C:
[1-333]
M
R
A
V
-
V
F
E
N
K
-
E
--
R
V
A
V
K
E
V
N
A
P
R
L
Q
H
P
L
D
A
L
V
R
V
H
L
A
G
I
C
G
S
D
L
-
H
L
Y
-
H
G
---
K
-
I
P
---
V
---
L
---
P
G
S
V
L
G
H
E
F
V
G
Q
V
E
A
V
G
E
G
I
-
D
L
Q
P
G
D
W
V
V
G
P
F
H
I
A
C
G
T
C
P
Y
C
R
R
H
Q
Y
N
L
C
E
R
G
G
V
Y
G
Y
GPMFG
N
-
L
-
Q
G
A
Q
A
E
I
L
R
V
P
FS
N
V
N
L
R
K
L
P
P
N
L
S
P
E
R
A
I
F
A
G
D
I
L
S
T
A
Y
G
G
L
I
Q
G
Q
L
R
P
G
D
S
V
A
V
I
G
A
G
P
V
G
L
M
A
I
E
V
A
Q
--
V
L
G
A
-
S
K
I
L
A
I
D
R
I
P
E
R
L
E
R
A
A
S
L
G
A
I
P
-
I
N
----
A
-----
E
----
Q
E
N
P
V
R
R
V
R
S
E
T
--
N
--
D
E
G
P
D
L
V
L
E
A
V
G
G
A
A
T
L
S
L
A
L
E
M
V
R
P
G
G
R
V
S
A
V
G
V
D
------
N
----
A
P
S
--
F
P
-
F
-
P
---
L
A
S
GLV
K
-
D
L
-
T
--
F
R
I
G
L
A
N
-
V
-
H
------
L
Y
I
D
A
-
V
L
A
L
L
A
S
G
R
L
Q
P
E
R
I
V
S
H
Y
L
-
P
L
E
E
A
P
R
G
Y
E
L
F
---------------
3
PsiBlast_PDB
74.58
34%
-116
- C1 -
2DFV
3
TDH_PYRHO
A:
[17-335]
--------------
E
L
V
E
V
D
V
P
K
P
---
G
P
G
E
V
L
I
K
V
L
A
T
S
I
C
G
T
D
L
-
H
I
Y
-
E
W
---
N
-
E
W
---
A
-
Q
S
R
IKP
P
-
Q
I
M
G
H
E
V
A
G
E
V
V
E
I
G
P
G
V
E
G
I
E
V
G
D
Y
V
S
V
E
T
H
I
V
C
G
K
C
Y
A
C
R
R
G
Q
Y
H
V
C
Q
N
T
K
I
F
G
V
-----
D
-
T
-
D
G
V
F
A
E
Y
A
V
V
P
--
A
Q
N
I
W
K
N
P
K
S
I
P
P
E
Y
A
T
L
Q
-
E
P
L
G
N
A
V
D
T
V
L
A
G
P
I
-
S
G
K
S
V
L
I
T
G
A
G
P
L
G
L
L
G
I
A
V
A
K
--
A
S
G
A
Y
P
-
V
I
V
S
E
P
S
D
F
R
R
E
L
A
K
K
V
G
A
D
Y
V
I
N
----
P
-----
F
----
E
E
D
V
V
K
E
V
M
D
I
T
--
D
--
G
N
G
V
D
V
F
L
E
F
S
G
A
P
K
A
L
E
Q
G
L
Q
A
V
T
P
A
G
R
V
S
L
L
G
L
Y
------
P
G
K
--
V
T
I
DF
N
N
-
L
-
I
---
I
F
K
---
A
-
L
T
-
I
Y
G
I
T
G
R
H
L
W
-
E
-
T
------
W
Y
--
T
-
V
S
R
L
L
Q
S
G
K
L
N
L
D
P
I
I
T
H
K
Y
K
G
F
D
K
Y
E
E
A
F
E
L
M
R
--------------
28
PsiBlast_CBE
74.51
32%
-119
- C1 -
4CPD
2
?
B:
[1-333]
M
R
A
V
-
V
F
E
N
K
-
E
--
R
V
A
V
K
E
V
N
A
P
R
L
Q
H
P
L
D
A
L
V
R
V
H
L
A
G
I
C
G
S
D
L
-
H
L
Y
-
H
G
---
K
-
I
P
---
V
---
L
---
P
G
S
V
L
G
H
E
F
V
G
Q
V
E
A
V
G
E
G
I
Q
D
L
Q
P
G
D
W
V
V
G
P
F
H
I
A
C
G
T
C
P
Y
C
R
R
H
Q
Y
N
L
C
E
R
G
G
V
Y
G
Y
GPMFG
N
-
L
-
Q
G
A
Q
A
E
I
L
R
V
P
FS
N
V
N
L
R
K
L
P
P
N
L
S
P
E
R
A
I
F
A
G
D
I
L
S
T
A
Y
G
G
L
I
Q
G
Q
L
R
P
G
D
S
V
A
V
I
G
A
G
P
V
G
L
M
A
I
E
V
A
Q
--
V
L
G
A
-
S
K
I
L
A
I
D
R
I
P
E
R
L
E
R
A
A
S
L
G
A
I
P
-
I
N
----
A
-----
E
----
Q
E
N
P
V
R
R
V
R
S
E
T
--
N
--
D
E
G
P
D
L
V
L
E
A
V
G
G
A
A
T
L
S
L
A
L
E
M
V
R
P
G
G
R
V
S
A
V
G
V
D
------
N
----
A
P
S
--
F
P
-
F
-
P
---
L
A
S
G
L
V
K
-
D
L
-
T
--
F
R
I
G
L
A
N
-
V
-
H
------
L
Y
I
D
A
-
V
L
A
L
L
A
S
G
R
L
Q
P
E
R
I
V
S
H
Y
L
-
P
L
E
E
A
P
R
G
Y
E
L
F
---------------
24
PsiBlast_CBE
72.87
34%
-111
- C1 -
3GFB
7
TDH_THEKO
B:
[5-336]
M
Q
A
I
M
K
T
K
P
A
-
Y
GA
E
L
V
E
V
D
V
P
K
P
---
G
P
G
E
V
L
I
K
V
L
A
T
S
I
C
G
T
D
L
-
H
I
Y
-
E
W
---
N
-
E
W
---
A
-
Q
S
R
IKP
P
-
Q
I
M
G
H
E
V
A
G
E
V
V
E
V
G
P
G
V
E
D
L
Q
V
G
D
Y
I
S
V
E
T
H
I
V
C
G
K
C
Y
A
C
K
H
N
R
Y
H
V
C
Q
N
T
K
I
F
G
V
-----
D
-
M
-
D
G
V
F
A
H
Y
A
I
V
P
--
A
K
N
A
W
K
N
P
K
D
M
P
P
E
Y
A
A
L
Q
-
E
P
L
G
N
A
V
D
T
V
L
A
G
P
I
-
A
G
R
S
T
L
I
T
G
A
G
P
L
G
L
L
G
I
A
V
A
K
--
A
S
G
A
Y
P
-
V
I
V
S
E
P
S
E
F
R
R
K
L
A
K
K
V
G
A
D
Y
V
V
N
----
P
-----
F
----
E
E
D
P
V
K
F
V
M
D
I
T
--
D
--
G
A
G
V
E
V
F
L
E
F
S
G
A
P
K
A
L
E
Q
G
L
K
A
V
T
P
G
G
R
V
S
L
L
G
L
F
------
P
R
E
--
V
T
I
DF
N
N
-
L
-
I
---
I
F
K
---
A
L
E
V
H
G
--
I
T
G
R
H
L
W
-
E
-
T
------
W
Y
--
T
-
V
S
S
L
I
Q
S
G
K
L
N
L
D
P
I
I
T
H
K
Y
K
G
F
D
K
F
E
E
A
F
E
L
M
R
--------------
26
PsiBlast_CBE
71.51
32%
-119
- C1 -
4CPD
3
?
D:
[1-333]
M
R
A
V
-
V
F
---------
A
V
K
E
V
N
A
P
R
L
Q
H
P
L
D
A
L
V
R
V
H
L
A
G
I
C
G
S
D
L
-
H
L
Y
-
H
G
---
K
-
I
P
---
V
---
L
---
P
-
S
V
L
G
H
E
F
V
G
Q
V
E
A
V
G
E
G
I
-
D
L
Q
P
G
D
W
V
V
G
P
F
H
I
A
C
G
T
C
P
Y
C
R
R
H
Q
Y
N
L
C
E
R
G
G
V
Y
G
Y
GPMFG
N
-
L
-
Q
G
A
Q
A
E
I
L
R
V
P
FS
N
V
N
L
R
K
L
P
P
N
L
S
P
E
R
A
I
F
A
G
D
I
L
S
T
A
Y
G
G
L
I
Q
G
Q
L
R
P
G
D
S
V
A
V
I
G
A
G
P
V
G
L
M
A
I
E
V
A
Q
--
V
L
G
A
-
S
K
I
L
A
I
D
R
I
P
E
R
L
E
R
A
A
S
L
G
A
I
P
-
I
N
----
A
-----
E
----
Q
E
N
P
V
R
R
V
R
S
E
T
--
N
--
D
E
G
P
D
L
V
L
E
A
V
G
G
A
A
T
L
S
L
A
L
E
M
V
R
P
G
G
R
V
S
A
V
G
V
D
------
N
----
A
P
S
--
F
P
-
F
-
P
---
L
A
S
GLV
K
-
D
L
-
T
--
F
R
I
G
L
A
N
-
V
-
H
------
L
Y
I
D
A
-
V
L
A
L
L
A
S
G
R
L
Q
P
E
R
I
V
S
H
Y
L
-
P
L
E
E
A
P
R
G
Y
E
L
F
---------------
5
PsiBlast_PDB
71.40
34%
-108
- C1 -
3GFB
2
TDH_THEKO
A:
[5-336]
M
Q
A
I
M
K
T
K
P
A
-
Y
GA
E
L
V
E
V
D
V
P
K
P
---
G
P
G
E
V
L
I
K
V
L
A
T
S
I
C
G
T
D
L
-
H
I
Y
-
E
W
---
N
-
E
W
---
A
-
Q
S
R
IKP
P
-
Q
I
M
G
H
E
V
A
G
E
V
V
E
V
G
P
G
V
E
D
L
Q
V
G
D
Y
I
S
V
E
T
H
I
V
C
G
K
C
Y
A
C
K
H
N
R
Y
H
V
C
Q
N
T
K
I
F
G
V
-----
D
-
M
-
D
G
V
F
A
H
Y
A
I
V
P
--
A
K
N
A
W
K
N
P
K
D
M
P
P
E
Y
A
A
L
Q
-
E
P
L
G
N
A
V
D
T
V
L
A
G
P
I
-
A
G
R
S
T
L
I
T
G
A
G
P
L
G
L
L
G
I
A
V
A
K
--
A
S
G
A
Y
P
-
V
I
V
S
E
P
S
E
F
R
R
K
L
A
K
K
V
G
A
D
Y
V
V
N
----
P
-----
F
----
E
E
D
P
V
K
F
V
M
D
I
T
--
D
--
G
A
G
V
E
V
F
L
E
F
S
G
A
P
K
A
L
E
Q
G
L
K
A
V
T
P
G
G
R
V
S
L
L
G
L
F
------
P
R
E
--
V
T
I
DF
N
N
-
L
-
I
---
I
F
K
---
A
L
E
V
H
G
--
I
T
G
R
H
L
W
-
E
-
T
------
W
Y
--
T
-
V
S
S
L
I
Q
S
G
K
L
N
L
D
P
I
I
T
H
K
Y
K
G
F
D
K
F
E
E
A
F
E
L
M
R
--------------
6
PsiBlast_PDB
71.23
34%
-127
- C1 -
3M6I
3
LAD_NEUCR
A:
[39-345]
---------------------------
K
E
G
E
V
T
V
A
V
R
S
T
G
I
C
G
S
D
V
-
H
F
W
K
H
G
---
C
I
G
P
---
M
I
V
E
C
---
D
-
H
V
L
G
H
E
S
A
G
E
V
I
A
V
H
P
S
V
K
S
I
K
V
G
D
R
V
A
I
E
P
Q
V
I
C
N
A
C
E
P
C
L
T
G
R
Y
N
G
C
E
R
V
D
F
L
S
T
-----
P
-
P
V
P
G
L
L
R
R
Y
V
N
H
P
--
A
V
W
C
H
K
I
G
-
N
M
S
Y
E
N
G
A
M
L
-
E
P
L
S
V
A
L
A
G
L
Q
R
A
G
V
R
L
G
D
P
V
L
I
C
G
A
G
P
I
G
L
I
T
M
L
C
A
K
--
A
A
G
A
-
C
P
L
V
I
T
D
I
D
E
G
R
L
K
F
A
K
E
I
C
P
E
V
V
T
H
K
V
E
R
L
-----
S
----
A
E
E
S
A
K
K
I
V
E
S
F
--
G
--
G
I
E
P
A
V
A
L
E
C
T
G
V
E
S
S
I
A
A
A
I
W
A
V
K
F
G
G
K
V
F
V
I
G
V
G
------
K
N
E
--
I
Q
I
--
P
F
-
M
-
R
---
A
S
V
---
R
-
E
V
-
D
--
L
Q
F
Q
Y
R
Y
-
C
-
N
------
T
W
-
P
R
-
A
I
R
L
V
E
N
G
L
V
D
L
T
R
L
V
T
H
R
F
-
P
L
E
D
A
L
K
A
F
E
-----------------
18
PsiBlast_PDB
70.57
30%
-118
- C1 -
4UEO
3
GATD_ECOLI
A:
[15-336]
------------------
A
E
S
V
I
P
E
I
K
H
Q
D
E
V
R
V
K
I
A
S
S
G
L
C
G
S
D
L
P
R
I
F
-
K
------
N
G
---
A
-
H
Y
Y
---
P
-
I
T
L
G
H
E
F
S
G
Y
I
D
A
V
G
S
G
V
D
D
L
H
P
G
D
A
V
A
C
V
P
L
L
P
C
F
T
C
P
E
C
L
K
G
F
Y
S
Q
C
A
K
Y
D
F
I
G
S
-----
R
-
R
-
D
G
G
F
A
E
Y
I
V
V
K
--
R
K
N
V
F
A
L
P
T
D
M
P
I
E
D
G
A
F
I
-
E
P
I
T
V
G
L
H
A
F
H
L
A
Q
G
C
E
N
K
N
V
I
I
I
G
A
G
T
I
G
L
L
A
I
Q
C
A
V
--
A
L
G
A
K
S
-
V
T
A
I
D
I
S
S
E
K
L
A
L
A
K
S
F
G
A
M
Q
T
F
N
SSE-
M
-----
S
----
A
P
Q
M
Q
S
V
L
R
E
L
R
--
F
--
N
Q
---
L
I
L
E
T
A
G
V
P
Q
T
V
E
L
A
V
E
I
A
G
P
H
A
Q
L
A
L
V
G
T
L
------
H
Q
D
--
L
H
L
--
T
S
-
A
-
T
F
G
K
I
L
R
---
K
-
E
L
-
T
--
V
I
G
S
W
M
N
-
Y
-
S
SPWPG
Q
E
W
-
E
T
-
A
S
R
L
L
T
E
R
K
L
S
L
E
P
L
I
A
H
R
G
-
S
F
E
S
F
A
Q
A
V
R
D
I
A
R
N
------------
70
HHSearch
70.05
32%
-106
- C1 -
2DQ4
3
TDH_THET8
A:
[1-341]
M
R
A
L
-
A
K
L
A
P
E
E
--
G
L
T
L
V
D
R
P
V
P
E
-
P
G
P
G
E
I
L
V
R
V
E
A
A
S
I
C
G
T
D
L
-
H
I
W
-
K
W
---
D
-
A
W
A
R
G
R
-
I
R
P
---
P
-
L
V
T
G
H
E
F
S
G
V
V
E
A
V
G
P
G
V
R
R
P
Q
V
G
D
H
V
S
L
E
S
H
I
V
C
H
A
C
P
A
C
R
T
G
N
Y
H
V
C
L
N
T
Q
I
L
G
V
-----
D
-
R
-
D
G
G
F
A
E
Y
V
V
V
P
--
A
E
N
A
W
V
N
P
K
D
L
P
F
E
V
A
A
I
L
-
E
P
F
G
N
A
V
H
T
V
Y
A
G
S
G
V
S
G
K
S
V
L
I
T
G
A
G
P
I
G
L
M
A
A
M
V
V
R
--
A
S
G
A
-
G
P
I
L
V
S
D
P
N
P
Y
R
L
A
F
A
R
P
Y
-
A
D
R
L
V
N
----
P
-----
L
----
E
E
D
L
L
E
V
V
R
R
V
T
-----
G
S
G
V
E
V
L
L
E
F
S
G
N
E
A
A
I
H
Q
G
L
M
A
L
I
P
G
G
E
A
R
I
L
G
I
P
------
S
D
P
--
I
R
F
--
D
L
A
G
-
E
---
L
V
M
---
R
-
G
I
-
T
--
A
F
G
I
A
G
R
-
R
L
W
------
Q
T
-
W
M
Q
G
T
A
L
V
Y
S
G
R
V
D
L
S
P
L
L
T
H
R
L
-
P
L
S
R
Y
R
E
A
F
G
L
L
A
S
G
--
Q
A
V
K
V
I
L
D
P
-
23
PsiBlast_CBE
69.99
34%
-105
- C1 -
3GFB
6
TDH_THEKO
C:
[5-336]
M
Q
A
I
M
K
T
K
P
A
-
Y
GA
E
L
V
E
V
D
V
P
K
P
---
G
P
G
E
V
L
I
K
V
L
A
T
S
I
C
G
T
D
L
-
H
I
Y
-
E
W
---
N
-
E
W
---
A
-
Q
S
R
IKP
P
-
Q
I
M
G
H
E
V
A
G
E
V
V
E
V
G
P
G
V
E
D
L
Q
V
G
D
Y
I
S
V
E
T
H
I
V
C
G
K
C
Y
A
C
K
H
N
R
Y
H
V
C
Q
N
T
K
I
F
G
V
-----
D
-
M
-
D
G
V
F
A
H
Y
A
I
V
P
--
A
K
N
A
W
K
N
P
K
D
M
P
P
E
Y
A
A
L
Q
-
E
P
L
G
N
A
V
D
T
V
L
A
G
P
I
-
A
G
R
S
T
L
I
T
G
A
G
P
L
G
L
L
G
I
A
V
A
K
--
A
S
G
A
Y
P
-
V
I
V
S
E
P
S
E
F
R
R
K
L
A
K
K
V
G
A
D
Y
V
V
N
----
P
-----
F
----
E
E
D
P
V
K
F
V
M
D
I
T
--
D
--
G
A
G
V
E
V
F
L
E
F
S
G
A
P
K
A
L
E
Q
G
L
K
A
V
T
P
G
G
R
V
S
L
L
G
L
F
------
P
R
E
--
V
T
I
DF
N
N
-
L
-
I
---
I
F
K
---
A
L
E
V
H
G
--
I
T
G
R
H
L
W
-
E
-
T
------
W
Y
--
T
-
V
S
S
L
I
Q
S
G
K
L
N
L
D
P
I
I
T
H
K
Y
K
G
F
D
K
F
E
E
A
F
E
L
M
R
--------------
25
PsiBlast_CBE
69.70
34%
-129
- C1 -
3M6I
3
LAD_NEUCR
B:
[39-345]
---------------------------
K
E
G
E
V
T
V
A
V
R
S
T
G
I
C
G
S
D
V
-
H
F
W
K
H
G
---
C
I
G
P
---
M
I
V
E
C
---
D
-
H
V
L
G
H
E
S
A
G
E
V
I
A
V
H
P
S
V
K
S
I
K
V
G
D
R
V
A
I
E
P
Q
V
I
C
N
A
C
E
P
C
L
T
G
R
Y
N
G
C
E
R
V
D
F
L
S
T
-----
P
-
P
V
P
G
L
L
R
R
Y
V
N
H
P
--
A
V
W
C
H
K
I
G
-
N
M
S
Y
E
N
G
A
M
L
-
E
P
L
S
V
A
L
A
G
L
Q
R
A
G
V
R
L
G
D
P
V
L
I
C
G
A
G
P
I
G
L
I
T
M
L
C
A
K
--
A
A
G
A
-
C
P
L
V
I
T
D
I
D
E
G
R
L
K
F
A
K
E
I
C
P
E
V
V
T
H
KVER
L
-----
S
----
A
E
E
S
A
K
K
I
V
E
S
F
--
G
--
G
I
E
P
A
V
A
L
E
C
T
G
V
E
S
S
I
A
A
A
I
W
A
V
K
F
G
G
K
V
F
V
I
G
V
G
------
K
N
E
--
I
Q
I
--
P
F
-
M
-
R
---
A
S
V
---
R
-
E
V
-
D
--
L
Q
F
Q
Y
R
Y
-
C
-
N
------
T
W
-
P
R
-
A
I
R
L
V
E
N
G
L
V
D
L
T
R
L
V
T
H
R
F
-
P
L
E
D
A
L
K
A
F
E
-----------------
12
PsiBlast_PDB
68.72
30%
-119
- C1 -
4EJ6
19
?
A:
[25-342]
-
K
A
V
-
R
L
E
S
V
-
G
--
N
I
S
V
R
N
V
G
I
P
E
P
G
P
D
D
-
L
L
V
K
V
E
A
C
G
I
C
G
T
D
R
-
H
L
L
-
H
G
---
E
-
F
P
-----
S
T
P
---
P
-
V
T
L
G
H
E
F
C
G
I
V
V
E
A
G
S
A
V
R
D
I
A
P
G
A
R
I
T
G
D
P
N
I
S
C
G
R
C
P
Q
C
Q
A
G
R
V
N
L
C
R
N
L
R
A
I
G
I
-----
H
-
R
-
D
G
G
F
A
E
Y
V
L
V
P
--
R
K
Q
A
F
E
I
P
L
T
L
D
P
V
H
G
A
F
C
-
E
P
L
A
C
C
L
H
G
V
D
L
S
G
I
K
A
G
S
T
V
A
I
L
G
G
G
V
I
G
L
L
T
V
Q
L
A
R
--
L
A
G
A
T
T
-
V
I
L
S
T
R
Q
A
T
K
R
R
L
A
E
E
V
G
A
T
A
T
V
D
----
P
-----
S
----
A
G
D
V
V
E
A
I
A
G
P
V
--
G
LV
P
G
G
V
D
V
V
I
E
C
A
G
V
A
E
T
V
K
Q
S
T
R
L
A
K
A
G
G
T
V
V
I
L
G
V
L
------
P
Q
G
--
E
K
V
--
E
I
-
E
-
P
F
D
-
I
L
F
---
R
-
E
L
-
R
--
V
L
G
S
F
I
N
-
P
-
F
------
V
H
-
R
R
-
A
A
D
L
V
A
T
G
A
I
E
I
D
R
M
I
S
R
R
I
-
S
L
D
E
-----------------------
16
PsiBlast_PDB
68.37
30%
-114
- C1 -
4UEJ
4
GATD_ECOLI
A:
[15-336]
------------------
A
E
S
V
I
P
E
I
K
H
Q
D
E
V
R
V
K
I
A
S
S
G
L
C
G
S
D
L
P
R
I
F
-
K
------
N
G
---
A
-
H
Y
Y
---
P
-
I
T
L
G
H
E
F
S
G
Y
I
D
A
V
G
S
G
V
D
D
L
H
P
G
D
A
V
A
C
V
P
L
L
P
C
F
T
C
P
E
C
L
K
G
F
Y
S
Q
C
A
K
Y
D
F
I
G
S
-----
R
-
R
-
D
G
G
F
A
E
Y
I
V
V
K
--
R
K
N
V
F
A
L
P
T
D
M
P
I
E
D
G
A
F
I
-
E
P
I
T
V
G
L
H
A
F
H
L
A
Q
G
C
E
N
K
N
V
I
I
I
G
A
G
T
I
G
L
L
A
I
Q
C
A
V
--
A
L
G
A
K
S
-
V
T
A
I
D
I
S
S
E
K
L
A
L
A
K
S
F
G
A
M
Q
T
F
N
SSE-
M
-----
S
----
A
P
Q
M
Q
S
V
L
R
E
L
R
--
F
--
N
Q
---
L
I
L
E
T
A
G
V
P
Q
T
V
E
L
A
V
E
I
A
G
P
H
A
Q
L
A
L
V
G
T
L
------
H
Q
D
--
L
H
L
--
T
S
-
A
-
T
F
G
K
I
L
R
---
K
-
E
L
-
T
--
V
I
G
S
W
M
N
-
Y
-
S
SPWPG
Q
E
W
-
E
T
-
A
S
R
L
L
T
E
R
K
L
S
L
E
P
L
I
A
H
R
G
-
S
F
E
S
F
A
Q
A
V
R
D
I
A
R
N
------------
17
PsiBlast_PDB
68.20
30%
-115
- C1 -
4UEK
4
GATD_ECOLI
A:
[15-336]
------------------
A
E
S
V
I
P
E
I
K
H
Q
D
E
V
R
V
K
I
A
S
S
G
L
C
G
S
D
L
P
R
I
F
-
K
------
N
G
---
A
-
H
Y
Y
---
P
-
I
T
L
G
H
E
F
S
G
Y
I
D
A
V
G
S
G
V
D
D
L
H
P
G
D
A
V
A
C
V
P
L
L
P
C
F
T
C
P
E
C
L
K
G
F
Y
S
Q
C
A
K
Y
D
F
I
G
S
-----
R
-
R
-
D
G
G
F
A
E
Y
I
V
V
K
--
R
K
N
V
F
A
L
P
T
D
M
P
I
E
D
G
A
F
I
-
E
P
I
T
V
G
L
H
A
F
H
L
A
Q
G
C
E
N
K
N
V
I
I
I
G
A
G
T
I
G
L
L
A
I
Q
C
A
V
--
A
L
G
A
K
S
-
V
T
A
I
D
I
S
S
E
K
L
A
L
A
K
S
F
G
A
M
Q
T
F
N
SSE-
M
-----
S
----
A
P
Q
M
Q
S
V
L
R
E
L
R
--
F
--
N
Q
---
L
I
L
E
T
A
G
V
P
Q
T
V
E
L
A
V
E
I
A
G
P
H
A
Q
L
A
L
V
G
T
L
------
H
Q
D
--
L
H
L
--
T
S
-
A
-
T
F
G
K
I
L
R
---
K
-
E
L
-
T
--
V
I
G
S
W
M
N
-
Y
-
S
SPWPG
Q
E
W
-
E
T
-
A
S
R
L
L
T
E
R
K
L
S
L
E
P
L
I
A
H
R
G
-
S
F
E
S
F
A
Q
A
V
R
D
I
A
R
N
------------
36
PsiBlast_CBE
55.29
33%
-110
- C1 -
2DQ4
3
TDH_THET8
B:
[27-329]
------------------------------
E
I
L
V
R
V
E
A
A
S
I
C
G
T
D
L
-
H
I
W
-
K
W
DAW
A
-
R
G
---
R
-
I
R
P
---
P
-
L
V
T
G
H
E
F
S
G
V
V
E
A
V
G
P
G
V
R
R
P
Q
V
G
D
H
V
S
L
E
S
H
I
V
C
H
A
C
P
A
C
R
T
G
N
Y
H
V
C
L
N
T
Q
I
L
G
V
-----
D
-
R
-
D
G
G
F
A
E
Y
V
V
V
P
--
A
E
N
A
W
V
N
P
K
D
L
P
F
E
V
A
A
I
L
-
E
P
F
G
N
A
V
H
T
V
Y
A
G
S
G
V
S
G
K
S
V
L
I
T
G
A
G
P
I
G
L
M
A
A
M
V
V
R
--
A
S
G
A
-
G
P
I
L
V
S
D
P
N
P
Y
R
L
A
F
A
R
P
Y
-
A
D
R
L
V
N
----
P
-----
L
----
E
E
D
L
L
E
V
V
R
R
V
T
--
G
--
S
-
G
V
E
V
L
L
E
F
S
G
N
E
A
A
I
H
Q
G
L
M
A
L
I
P
G
G
E
A
R
I
L
G
I
P
SDPIRF
D
L
A
--
G
E
L
--
V
M
-
R
-
G
---
I
T
A
------
F
-
G
--
I
A
G
R
R
L
W
-
Q
-
T
------
W
M
--
Q
-
G
T
A
L
V
Y
S
G
R
V
D
L
S
P
L
L
T
H
R
L
-
P
L
S
R
Y
R
E
A
F
G
L
L
---------------
10
PsiBlast_PDB
53.72
33%
-108
- C1 -
2DQ4
3
TDH_THET8
A:
[27-329]
------------------------------
E
I
L
V
R
V
E
A
A
S
I
C
G
T
D
L
-
H
I
W
-
K
W
D
A
W
A
-
R
G
---
R
-
I
R
P
---
P
-
L
V
T
G
H
E
F
S
G
V
V
E
A
V
G
P
G
V
R
R
P
Q
V
G
D
H
V
S
L
E
S
H
I
V
C
H
A
C
P
A
C
R
T
G
N
Y
H
V
C
L
N
T
Q
I
L
G
V
-----
D
-
R
-
D
G
G
F
A
E
Y
V
V
V
P
--
A
E
N
A
W
V
N
P
K
D
L
P
F
E
V
A
A
I
L
-
E
P
F
G
N
A
V
H
T
V
Y
A
G
S
G
V
S
G
K
S
V
L
I
T
G
A
G
P
I
G
L
M
A
A
M
V
V
R
--
A
S
G
A
-
G
P
I
L
V
S
D
P
N
P
Y
R
L
A
F
A
R
P
Y
-
A
D
R
L
V
N
----
P
-----
L
----
E
E
D
L
L
E
V
V
R
R
V
T
--
G
--
S
-
G
V
E
V
L
L
E
F
S
G
N
E
A
A
I
H
Q
G
L
M
A
L
I
P
G
G
E
A
R
I
L
G
I
P
SDPIRF
D
L
A
--
G
E
L
--
V
M
-
R
-
G
---
I
T
A
------
F
-
G
--
I
A
G
R
R
L
W
-
Q
-
T
------
W
M
--
Q
-
G
T
A
L
V
Y
S
G
R
V
D
L
S
P
L
L
T
H
R
L
-
P
L
S
R
Y
R
E
A
F
G
L
L
---------------