@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu18560: (2016-06-30 )
MKNTMKRMFCSMTVLVTAPYNEEGRKELENLFGSVAYQSWKEQGRAYREDELIQLLKATNATGLITELDQVTDSVFASVPELSFVGVCRGMPSNVDVAAASKRGIPVFYTPGRNAQAVAEMFIGNVISFLRHTSASNQWLKDGEWDSDYLQAYVKFKGNELTGKTVGMIGFGAVGQRIAKLLTAFDCKIKYYDPYIQDDHPLYEKASLKTVFSDSDIVSVHLPRTEETLGLIDRQYFDLMKESAIFVNTSRAVVVNREDLLFVLKEHKISGAILDVFYHEPPEESDYELISLPNVLATPHLAGATFEVEDHHVTILNKALKKWKGEKTLNIQTMYNKDALKTGG
Atome Classification :
(24 SA)
.........10........20........30........40........50........60.....-...70...-.....80........90........100.......110.......120.......130.......140.......150-.-..-....160.......170.......180.......190.......---200---.---.---....--------..210--........220.......230.......240.......250.......260.......270.......280.---....---...290.......300.......310-.......320-.-.-.....330.......340..------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MK
N
T
M
K
R
M
FCS
M
T
V
L
V
TAPY
N
E
E
G
R
K
E
L
E
N
L
F
G
S
V
A
Y
Q
S
W
K
E
QGRAY
R
E
D
E
L
I
Q
L
L
K
ATNAT
G
L
I
T
-
E
L
D
Q
V
T
D
S
-
V
F
ASVPE
L
S
F
V
G
VCRGMPSNV
D
V
AAASKRG
I
P
V
F
YTPGR
N
A
Q
A
V
A
E
M
F
I
G
N
V
I
S
F
L
RHTSASNQWLKDGEW
D
S
D
Y
L
Q
A
-
Y
-
V
K-FKGNELTG
K
T
V
G
M
I
G
F
G
A
V
G
Q
R
I
A
K
L
L
T
A
FD
C
K
I
K
YYDPYIQDD---HP----
L
---
Y
---
E
KAS--------
L
K
T
V---FSDS
D
I
V
S
V
HLPR
T
E
E
T
L
G
L
I
D
R
Q
Y
F
D
L
M
K
E
S
A
I
F
V
NT
S
R
A
V
V
VN
R
E
D
L
L
F
V
L
K
EHKIS
G
A
I
L
D
V
F
YHEP-P---EESD---
Y
E
L
ISLP
N
V
LATPHLAG
A
T
F
E
VED
H
H
-
V
T
I
L
N
K
A
L
K
K-W-K-G
E
K
T
L
N
I
Q
T
M
YNKDALKTGG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
86.27
35%
-54
- C3 -
1WWK
1
?
A:
[4-307]
-------
M
----
K
V
L
V
A
A
P
L
H
E
K
A
I
Q
V
L
K
D
A
G
L
E
V
I
Y
E
E
Y
P
D
------
E
D
R
L
V
E
L
V
K
D
V
E
A
I
-
I
V
R
-
S
K
P
K
V
T
R
R
-
V
I
E
S
A
P
K
L
K
V
I
A
R
A
G
V
G
L
D
N
I
D
V
E
A
A
K
E
K
G
I
E
V
V
N
A
P
A
A
S
S
R
S
V
A
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L
A
V
G
L
M
F
S
V
A
R
K
I
A
F
A
D
R
K
M
R
E
G
V
W
------
A
-
K
-
K
E
-
A
M
G
I
E
L
E
G
K
T
I
G
I
I
G
F
G
R
I
G
Y
Q
V
A
K
I
A
N
A
L
G
M
N
I
L
L
Y
D
P
Y
--------
P
----
N
---
E
---
E
R
A
K
E
V
N
G
K
F
V
D
L
E
T
L
---
L
K
E
S
D
V
V
T
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H
V
P
L
V
E
S
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
T
S
R
G
P
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
L
P
---
K
--
D
---
H
P
L
T
K
F
D
N
V
V
L
T
P
H
I
G
A
S
T
V
E
A
Q
E
R
A
G
V
E
V
A
E
K
V
V
K
I
-
L
-
K
-
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
Fugue
85.87
29%
-71
- C3 -
1YGY
1
SERA_MYCTU
A:
[3-529]
---------
S
L
P
V
V
L
I
A
D
K
L
A
P
S
T
V
A
A
L
G
D
-------
Q
V
E
V
R
W
V
D
G
P
D
R
D
K
L
L
A
A
V
P
E
A
D
A
L
-
L
V
R
-
S
A
T
T
V
D
A
E
-
V
L
A
A
A
P
K
L
K
I
V
A
R
A
G
V
G
L
D
N
V
D
V
D
A
A
T
A
R
G
V
L
V
V
N
A
P
T
S
N
I
H
S
A
A
E
H
A
L
A
L
L
L
A
A
S
R
Q
I
P
A
A
D
A
S
L
R
E
H
T
W
K
R
S
S
---------
F
S
G
T
E
I
F
G
K
T
V
G
V
V
G
L
G
R
I
G
Q
L
V
A
Q
R
I
A
A
F
G
A
Y
V
V
A
Y
D
P
Y
V
S
P
A
---
R
A
----
A
---
Q
L
G
I
E
L
L
S
--------
L
D
D
L
---
L
A
R
A
D
F
I
S
V
H
L
P
K
T
P
E
T
A
G
L
I
D
K
E
A
L
A
K
T
K
P
G
V
I
I
V
N
A
A
R
G
G
L
V
D
E
A
A
L
A
D
A
I
T
G
G
H
V
R
A
A
G
L
D
V
F
A
T
E
P
-
C
---
T
D
S
-----
P
L
F
E
L
A
Q
V
V
V
T
P
H
L
G
A
S
T
A
E
A
Q
D
R
A
-
G
T
D
V
A
E
S
V
R
L
-
A
L
A
-
G
E
F
V
P
D
A
V
N
V
G
G
G
V
V
N
E
E
V
A
P
W
L
D
L
V
R
K
L
G
V
L
A
G
V
L
SDELPV
S
L
S
V
Q
V
R
G
ELAAEEV
E
V
L
R
L
S
A
L
R
G
L
F
SAVIEDAVTFVN
A
P
A
L
A
A
E
RG
V
T
A
E
I
C
K
A
SESPNHR
S
V
V
D
V
R
A
V
G
ADG
S
V
V
T
V
S
G
T
L
Y
G
PQLSQKIVQING
R
H
F
D
L
R
AQ
G
I
N
L
I
I
H
Y
V
DRPG
A
L
G
K
I
G
T
L
L
G
T
A
GVNIQ
A
A
Q
L
S
E
D
AEGP
G
A
T
I
L
L
R
L
D
Q
D
V
P
D
D
V
R
T
A
I
A
A
A
VDAY
K
L
E
V
V
D
LS
21
PsiBlast_CBE
84.02
35%
-58
- C3 -
1WWK
1
?
B:
[4-305]
-------
M
----
K
V
L
V
A
A
P
L
H
E
K
A
I
Q
V
L
K
D
A
G
L
E
V
I
Y
E
E
Y
P
D
------
E
D
R
L
V
E
L
V
K
D
V
E
A
I
-
I
V
R
-
S
K
P
K
V
T
R
R
-
V
I
E
S
A
P
K
L
K
V
I
A
R
A
G
V
G
L
D
N
I
D
V
E
A
A
K
E
K
G
I
E
V
V
N
A
P
A
A
S
S
R
S
V
A
E
L
A
V
G
L
M
F
S
V
A
R
K
I
A
F
A
D
R
K
M
R
E
G
V
W
------
A
-
K
-
K
E
-
A
M
G
I
E
L
E
G
K
T
I
G
I
I
G
F
G
R
I
G
Y
Q
V
A
K
I
A
N
A
L
G
M
N
I
L
L
Y
D
P
Y
--------
P
----
N
---
E
---
E
R
A
K
EVNGKFVD
L
E
T
L
---
L
K
E
S
D
V
V
T
I
H
V
P
L
V
E
S
T
Y
H
L
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K
T
A
I
L
I
N
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P
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D
T
N
A
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K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
L
P
---
K
--
D
---
H
P
L
T
K
F
D
N
V
V
L
T
P
H
I
G
A
S
T
V
E
A
Q
E
R
A
G
V
E
V
A
E
K
V
V
K
I
-
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
HHSearch
80.41
35%
-22
- C3 -
1WWK
1
?
A:
[4-307]
-----------
M
K
V
L
V
A
A
P
L
H
E
K
A
I
Q
V
L
K
D
-
A
G
L
E
V
I
Y
E
E
Y
-----
P
D
E
D
R
L
V
E
L
V
--
K
D
V
E
A
I
I
V
R
S
K
P
K
V
T
R
R
-
V
I
E
S
A
P
K
L
K
V
I
A
R
A
G
V
G
L
D
N
I
D
V
E
A
A
K
E
K
G
I
E
V
V
N
A
P
A
A
S
S
R
S
V
A
E
L
A
V
G
L
M
F
S
V
A
R
K
I
A
F
A
D
R
K
M
R
E
G
V
W
A
K
K
E
A
---------
M
G
I
E
L
E
G
K
T
I
G
I
I
G
F
G
R
I
G
Y
Q
V
A
K
I
A
N
A
L
G
M
N
I
L
L
Y
D
P
Y
P
N
E
E
R
A
K
E
V
----
N
---
G
---
K
F
V
D
--------
L
E
T
L
---
L
K
E
S
D
V
V
T
I
H
V
P
L
V
E
S
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
T
S
R
G
P
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
-
L
---
P
K
-
D
---
H
P
L
T
K
F
D
N
V
V
L
T
P
H
I
G
A
S
T
V
E
A
Q
E
R
A
-
G
V
E
V
A
E
K
V
V
K
I
L
-
K
-
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
80.41
31%
-72
- C3 -
3DC2
-
SERA_MYCTU
A:
[36-317]
-------------------------------------------------
D
K
L
L
A
A
V
P
E
A
D
A
L
-
L
V
R
-
S
A
T
T
V
D
A
E
-
V
L
A
A
A
P
K
L
K
I
V
A
R
A
G
V
G
L
D
N
V
D
V
D
A
A
T
A
R
G
V
L
V
V
N
A
P
T
S
N
I
H
S
A
A
E
H
A
L
A
L
L
L
A
A
S
R
Q
I
P
A
A
D
A
S
L
R
E
H
T
W
K
R
S
--------
S
-
F
S
G
T
E
I
F
G
K
T
V
G
V
V
G
L
G
R
I
G
Q
L
V
A
Q
R
I
A
A
F
G
A
Y
V
V
A
Y
D
P
Y
V
S
P
A
---
R
A
----
A
Q
L
G
I
---
E
L
L
S
--------
L
D
D
L
---
L
A
R
A
D
F
I
S
V
H
L
P
K
T
P
E
T
A
G
L
I
D
K
E
A
L
A
K
T
K
P
G
V
I
I
V
N
A
A
R
G
G
L
V
D
E
A
A
L
A
D
A
I
T
G
G
H
V
R
A
A
G
L
D
V
F
A
T
E
P
-
C
-----
T
D
---
S
P
L
F
E
L
A
Q
V
V
V
T
P
H
L
G
A
S
T
A
E
A
Q
D
R
A
-
G
T
D
V
A
E
S
V
R
----------
L
A
L
A
G
E
F
V
P
D
A
V
N
V
G
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
78.97
31%
-71
- C3 -
3DDN
1
SERA_MYCTU
A:
[35-316]
-------------------------------------------------
D
K
L
L
A
A
V
P
E
A
D
A
L
-
L
V
R
-
S
A
T
T
V
D
A
E
-
V
L
A
A
A
P
K
L
K
I
V
A
R
A
G
V
G
L
D
N
V
D
V
D
A
A
T
A
R
G
V
L
V
V
N
A
P
T
S
N
I
H
S
A
A
E
H
A
L
A
L
L
L
A
A
S
R
Q
I
P
A
A
D
A
S
L
R
E
H
T
W
K
R
S
--------
S
-
F
S
G
T
E
I
F
G
K
T
V
G
V
V
G
L
G
R
I
G
Q
L
V
A
Q
R
I
A
A
F
G
A
Y
V
V
A
Y
D
P
Y
V
S
P
A
---
R
A
----
A
Q
L
G
I
---
E
L
L
S
--------
L
D
D
L
---
L
A
R
A
D
F
I
S
V
H
L
P
K
T
P
E
T
A
G
L
I
D
K
E
A
L
A
K
T
K
P
G
V
I
I
V
N
A
A
R
G
G
L
V
D
E
A
A
L
A
D
A
I
T
G
G
H
V
R
A
A
G
L
D
V
F
A
T
E
P
-
C
-----
T
D
---
S
P
L
F
E
L
A
Q
V
V
V
T
P
H
L
G
A
S
T
A
E
A
Q
D
R
A
-
G
T
D
V
A
E
S
V
R
----------
L
A
L
A
G
E
F
V
P
D
A
V
N
V
G
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
78.68
31%
-74
- C3 -
1YGY
-
SERA_MYCTU
A:
[36-317]
-------------------------------------------------
D
K
L
L
A
A
V
P
E
A
D
A
L
-
L
V
R
-
S
A
T
T
V
D
A
E
-
V
L
A
A
A
P
K
L
K
I
V
A
R
A
G
V
G
L
D
N
V
D
V
D
A
A
T
A
R
G
V
L
V
V
N
A
P
T
S
N
I
H
S
A
A
E
H
A
L
A
L
L
L
A
A
S
R
Q
I
P
A
A
D
A
S
L
R
E
H
T
W
K
R
S
--------
S
-
F
S
G
T
E
I
F
G
K
T
V
G
V
V
G
L
G
R
I
G
Q
L
V
A
Q
R
I
A
A
F
G
A
Y
V
V
A
Y
D
P
Y
V
S
P
A
---
R
A
----
A
Q
L
G
I
---
E
L
L
S
--------
L
D
D
L
---
L
A
R
A
D
F
I
S
V
H
L
P
K
T
P
E
T
A
G
L
I
D
K
E
A
L
A
K
T
K
P
G
V
I
I
V
N
A
A
R
G
G
L
V
D
E
A
A
L
A
D
A
I
T
G
G
H
V
R
A
A
G
L
D
V
F
A
T
E
P
-
C
-----
T
D
---
S
P
L
F
E
L
A
Q
V
V
V
T
P
H
L
G
A
S
T
A
E
A
Q
D
R
A
-
G
T
D
V
A
E
S
V
R
----------
L
A
L
A
G
E
F
V
P
D
A
V
N
V
G
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
76.95
31%
-71
- C3 -
3DDN
1
SERA_MYCTU
B:
[35-318]
-------------------------------------------------
D
K
L
L
A
A
V
P
E
A
D
A
L
-
L
V
R
-
S
A
T
T
V
D
A
E
-
V
L
A
A
A
P
K
L
K
I
V
A
R
A
G
V
G
L
D
N
V
D
V
D
A
A
T
A
R
G
V
L
V
V
N
A
P
T
S
N
I
H
S
A
A
E
H
A
L
A
L
L
L
A
A
S
R
Q
I
P
A
A
D
A
S
L
R
E
H
T
W
K
R
S
--------
S
-
F
S
G
T
E
I
F
G
K
T
V
G
V
V
G
L
G
R
I
G
Q
L
V
A
Q
R
I
A
A
F
G
A
Y
V
V
A
Y
D
P
Y
V
S
P
A
---
R
A
----
A
Q
L
G
I
---
E
L
L
S
--------
L
D
D
L
---
L
A
R
A
D
F
I
S
V
H
L
P
K
T
P
E
T
A
G
L
I
D
K
E
A
L
A
K
T
K
P
G
V
I
I
V
N
A
A
R
G
G
L
V
D
E
A
A
L
A
D
A
I
T
G
G
H
V
R
A
A
G
L
D
V
F
A
T
E
P
-
C
-----
T
D
---
S
P
L
F
E
L
A
Q
V
V
V
T
P
H
L
G
A
S
T
A
E
A
Q
D
R
A
-
G
T
D
V
A
E
S
V
R
----------
L
A
L
A
G
E
F
V
P
D
A
V
N
V
G
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
75.48
32%
-21
- C3 -
2DBR
3
GYAR_PYRHO
D:
[5-327]
-------------
V
F
I
T
R
E
I
P
E
V
G
I
K
M
L
E
D
E
F
---
E
V
E
V
W
G
D
E
K
E
I
P
R
E
---
I
L
L
K
K
V
K
E
V
D
A
L
V
T
-
M
L
S
E
R
I
D
K
E
V
F
E
N
A
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
V
R
S
G
E
W
K
K
R
G
V
A
W
-
H
-
P
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
G
F
N
M
R
I
L
Y
Y
S
R
T
R
K
E
E
---
V
E
----
R
---
E
---
L
N
A
E
--------
F
K
P
L
EDL
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
------
Y
Y
N
---
E
E
L
F
K
L
D
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
-
A
E
L
V
A
K
N
L
I
A
-
F
-
K
R
G
E
I
P
---
P
T
L
V
N
R
E
V
I
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
75.19
32%
-18
- C3 -
2DBZ
3
GYAR_PYRHO
A:
[5-327]
-------------
V
F
I
T
R
E
I
P
E
V
G
I
K
M
L
E
D
E
F
---
E
V
E
V
W
G
D
E
K
E
I
P
R
E
---
I
L
L
K
K
V
K
E
V
D
A
L
V
T
-
M
L
S
E
R
I
D
K
E
V
F
E
N
A
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
V
R
S
G
E
W
K
K
R
G
V
A
W
-
H
-
P
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
G
F
N
M
R
I
L
Y
Y
S
R
T
R
K
E
E
---
V
E
----
R
---
E
---
L
N
A
E
--------
F
K
P
L
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
------
Y
Y
N
---
E
E
L
F
K
L
D
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
-
A
E
L
V
A
K
N
L
I
A
-
F
-
K
R
G
E
I
P
---
P
T
L
V
N
R
E
V
I
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
74.93
32%
-17
- C3 -
2DBQ
8
GYAR_PYRHO
A:
[5-327]
-------------
V
F
I
T
R
E
I
P
E
V
G
I
K
M
L
E
D
E
F
---
E
V
E
V
W
G
D
E
K
E
I
P
R
E
---
I
L
L
K
K
V
K
E
V
D
A
L
V
T
-
M
L
S
E
R
I
D
K
E
V
F
E
N
A
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
V
R
S
G
E
W
K
K
R
G
V
A
W
-
H
-
P
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
G
F
N
M
R
I
L
Y
Y
S
R
T
R
K
E
E
---
V
E
----
R
---
E
---
L
N
A
E
--------
F
K
P
L
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
------
Y
Y
N
---
E
E
L
F
K
L
D
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
-
A
E
L
V
A
K
N
L
I
A
-
F
-
K
R
G
E
I
P
---
P
T
L
V
N
R
E
V
I
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
74.88
30%
-81
- C3 -
3K5P
3
?
A:
[32-320]
-------------------------------
F
K
S
S
G
Y
T
N
V
T
H
L
P
K
A
L
D
K
A
D
L
I
K
A
I
S
S
A
H
I
I
G
-
I
R
-
S
R
T
Q
L
T
E
E
-
I
F
A
A
A
N
R
L
I
A
V
G
C
F
S
V
G
T
N
Q
V
E
L
K
A
A
R
K
R
G
I
P
V
F
N
A
P
F
S
N
T
R
S
V
A
E
L
V
I
G
E
I
I
M
L
M
R
R
I
F
P
R
S
V
S
A
H
A
G
G
W
E
K
T
A
I
G
S
---------
R
E
V
R
G
K
T
L
G
I
V
G
Y
G
N
I
G
S
Q
V
G
N
L
A
E
S
L
G
M
T
V
R
Y
Y
D
T
S
D
K
L
Q
---
Y
G
N---
V
---
K
---
P
A
A
S
--------
L
D
E
L
---
L
K
T
S
D
V
V
S
L
H
V
P
-----
S
K
L
I
T
E
A
K
L
R
K
M
K
K
G
A
F
L
I
N
N
A
R
G
S
D
V
D
L
E
A
L
A
K
V
L
Q
E
G
H
L
A
G
A
A
I
D
V
F
P
V
E
P
-
A
SNG
E
R
F
S
---
T
P
L
Q
G
L
E
N
V
I
L
T
P
H
I
G
G
S
T
E
E
A
Q
E
R
I
-
G
T
E
V
T
R
K
L
V
E
-
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
74.75
32%
-19
- C3 -
2DBR
3
GYAR_PYRHO
E:
[5-327]
-------------
V
F
I
T
R
E
I
P
E
V
G
I
K
M
L
E
D
E
F
---
E
V
E
V
W
G
D
E
K
E
I
P
R
E
---
I
L
L
K
K
V
K
E
V
D
A
L
V
T
-
M
L
S
E
R
I
D
K
E
V
F
E
N
A
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
V
R
S
G
E
W
K
K
R
G
V
A
W
-
H
-
P
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
G
F
N
M
R
I
L
Y
Y
S
R
T
R
K
E
E
---
V
E
----
R
---
E
---
L
N
A
E
--------
F
K
P
L
EDL
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
------
Y
Y
N
---
E
E
L
F
K
L
D
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
-
A
E
L
V
A
K
N
L
I
A
-
F
-
K
R
G
E
I
P
---
P
T
L
V
N
R
E
V
I
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
74.68
32%
-20
- C3 -
2DBZ
3
GYAR_PYRHO
B:
[5-327]
-------------
V
F
I
T
R
E
I
P
E
V
G
I
K
M
L
E
D
E
F
---
E
V
E
V
W
G
D
E
K
E
I
P
R
E
---
I
L
L
K
K
V
K
E
V
D
A
L
V
T
-
M
L
S
E
R
I
D
K
E
V
F
E
N
A
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
V
R
S
G
E
W
K
K
R
G
V
A
W
-
H
-
P
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
G
F
N
M
R
I
L
Y
Y
S
R
T
R
K
E
E
---
V
E
----
R
---
E
---
L
N
A
E
--------
F
K
P
L
EDL
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
------
Y
Y
N
---
E
E
L
F
K
L
D
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
-
A
E
L
V
A
K
N
L
I
A
-
F
-
K
R
G
E
I
P
---
P
T
L
V
N
R
E
V
I
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
74.65
32%
-17
- C3 -
2DBR
3
GYAR_PYRHO
A:
[5-327]
-------------
V
F
I
T
R
E
I
P
E
V
G
I
K
M
L
E
D
E
F
---
E
V
E
V
W
G
D
E
K
E
I
P
R
E
---
I
L
L
K
K
V
K
E
V
D
A
L
V
T
-
M
L
S
E
R
I
D
K
E
V
F
E
N
A
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
V
R
S
G
E
W
K
K
R
G
V
A
W
-
H
-
P
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
G
F
N
M
R
I
L
Y
Y
S
R
T
R
K
E
E
---
V
E
----
R
---
E
---
L
N
A
E
--------
F
K
P
L
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
------
Y
Y
N
---
E
E
L
F
K
L
D
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
-
A
E
L
V
A
K
N
L
I
A
-
F
-
K
R
G
E
I
P
---
P
T
L
V
N
R
E
V
I
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
74.62
32%
-19
- C3 -
2DBR
3
GYAR_PYRHO
B:
[5-327]
-------------
V
F
I
T
R
E
I
P
E
V
G
I
K
M
L
E
D
E
F
---
E
V
E
V
W
G
D
E
K
E
I
P
R
E
---
I
L
L
K
K
V
K
E
V
D
A
L
V
T
-
M
L
S
E
R
I
D
K
E
V
F
E
N
A
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
V
R
S
G
E
W
K
K
R
G
V
A
W
-
H
-
P
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
G
F
N
M
R
I
L
Y
Y
S
R
T
R
K
E
E
---
V
E
----
R
---
E
---
L
N
A
E
--------
F
K
P
L
EDL
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
------
Y
Y
N
---
E
E
L
F
K
L
D
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
-
A
E
L
V
A
K
N
L
I
A
-
F
-
K
R
G
E
I
P
---
P
T
L
V
N
R
E
V
I
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
74.26
32%
-19
- C3 -
2DBR
4
GYAR_PYRHO
C:
[5-327]
-------------
V
F
I
T
R
E
I
P
E
V
G
I
K
M
L
E
D
E
F
---
E
V
E
V
W
G
D
E
K
E
I
P
R
E
---
I
L
L
K
K
V
K
E
V
D
A
L
V
T
-
M
L
S
E
R
I
D
K
E
V
F
E
N
A
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
V
R
S
G
E
W
K
K
R
G
V
A
W
-
H
-
P
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
G
F
N
M
R
I
L
Y
Y
S
R
T
R
K
E
E
---
V
E
----
R
---
E
---
L
N
A
E
--------
F
K
P
L
EDL
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
------
Y
Y
N
---
E
E
L
F
K
L
D
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
-
A
E
L
V
A
K
N
L
I
A
-
F
-
K
R
G
E
I
P
---
P
T
L
V
N
R
E
V
I
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
74.03
32%
-15
- C3 -
2DBR
3
GYAR_PYRHO
F:
[5-327]
-------------
V
F
I
T
R
E
I
P
E
V
G
I
K
M
L
E
D
E
F
---
E
V
E
V
W
G
D
E
K
E
I
P
R
E
---
I
L
L
K
K
V
K
E
V
D
A
L
V
T
-
M
L
S
E
R
I
D
K
E
V
F
E
N
A
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
V
R
S
G
E
W
K
K
R
G
V
A
W
-
H
-
P
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
G
F
N
M
R
I
L
Y
Y
S
R
T
R
K
E
E
---
V
E
----
R
---
E
---
L
N
A
E
--------
F
K
P
L
EDL
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
------
Y
Y
N
---
E
E
L
F
K
L
D
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
-
A
E
L
V
A
K
N
L
I
A
-
F
-
K
R
G
E
I
P
---
P
T
L
V
N
R
E
V
I
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
HHSearch
73.41
32%
-16
- C3 -
5AOV
24
?
A:
[1-327]
---------
M
K
P
K
V
F
I
T
R
A
I
P
E
N
G
I
N
M
L
E
E
--
E
F
E
V
E
V
W
E
E
--
E
R
E
I
P
R
E
K
L
L
E
K
V
--
K
D
V
D
A
L
V
T
M
L
S
E
R
I
D
Q
E
-
V
F
E
N
A
P
R
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
V
E
E
A
T
R
R
G
I
Y
V
T
N
T
P
D
V
L
T
N
A
T
A
D
H
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
K
F
V
R
S
G
E
W
K
R
K
G
I
A
W
H
P
-
K
W
-
F
L
G
Y
E
L
Y
G
K
T
I
G
I
V
G
F
G
R
I
G
Q
A
I
A
R
R
A
K
G
F
N
M
R
I
L
Y
Y
S
R
T
R
K
S
Q
A
E
K
E
L
----
G
---
A
---
E
Y
R
P
--------
L
E
E
V
---
L
K
E
S
D
F
V
I
L
A
V
P
L
T
K
E
T
M
Y
M
I
N
E
E
R
L
K
L
M
K
P
T
A
I
L
V
N
I
A
R
G
K
V
V
D
T
K
A
L
I
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
-
Y
---
Y
--
N
---
E
E
L
F
S
L
D
N
V
V
L
T
P
H
I
G
S
A
T
F
E
A
R
E
A
M
-
A
E
L
V
A
R
N
L
I
A
F
K
-
R
-
G
E
I
P
P
T
L
---
V
N
K
E
V
I
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
72.93
29%
-72
- C3 -
2P9G
1
SERA_ECOLI
A:
[21-303]
------------------------
Q
K
A
L
E
S
L
R
A
A
-
G
Y
T
N
I
E
F
H
K
G
A
L
D
D
E
Q
L
K
E
S
I
R
D
A
H
F
I
G
L
R
S
-
R
-
T
H
L
T
E
D
-
V
I
N
A
A
E
K
L
V
A
I
G
A
F
A
I
G
T
N
Q
V
D
L
D
A
A
A
K
R
G
I
P
V
F
N
A
P
F
S
N
T
R
S
V
A
E
L
V
I
G
E
L
L
L
L
L
R
G
V
P
E
A
N
A
K
A
H
R
G
V
W
N
K
L
A
A
G
S
-
F
--------
E
A
R
G
K
K
L
G
I
I
G
Y
G
H
I
G
T
Q
L
G
I
L
A
E
S
L
G
M
Y
V
Y
F
Y
D
--
I
E
N
K
---
L
P
----
L
GN
A
T
---
Q
V
Q
H
--------
L
S
D
L
---
L
N
M
S
D
V
V
S
L
H
V
P
E
N
P
S
T
K
N
M
M
G
A
K
E
I
S
L
M
K
P
G
S
L
L
I
N
A
S
R
G
T
V
V
D
I
P
A
L
A
D
A
L
A
S
K
H
L
A
G
A
A
I
D
V
F
P
T
E
P
-
A
---
T
N
S
D
P
F
T
S
P
L
A
E
F
D
N
V
L
L
T
P
H
I
G
G
S
T
Q
E
A
Q
E
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
50.10
31%
-14
- C3 -
1MX3
2
CTBP1_HUMAN
A:
[98-311]
-----------------------------------------------------------------------------------------------
N
I
D
I
K
S
A
G
D
L
G
I
A
V
C
N
V
P
A
A
S
V
E
E
T
A
D
S
T
L
C
H
I
L
N
L
Y
R
R
A
T
W
L
H
Q
A
L
R
E
G
T
R
V
Q
S
V
E
Q
I
-
R
E
V
A
-
S
G
A
A
R
I
R
G
E
T
L
G
I
I
G
L
G
R
V
G
Q
A
V
A
L
R
A
K
A
F
G
F
N
V
L
F
Y
D
P
Y
L
S
D
G
---
V
E
R
A
L
G
L
---
Q
---
R
V
S
T
--------
L
Q
D
L
---
L
F
H
S
D
C
V
T
L
H
C
G
L
N
E
H
N
H
H
L
I
N
D
F
T
V
K
Q
M
R
Q
G
A
F
L
V
N
T
A
R
G
G
L
V
D
E
K
A
L
A
Q
A
L
K
E
G
R
I
R
G
A
A
L
D
V
H
E
S
E
P
-
F
---
S
F
S
Q
---
G
P
L
K
D
A
P
N
L
I
C
T
P
H
A
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
49.64
31%
-14
- C3 -
4LCE
2
CTBP1_HUMAN
A:
[98-311]
-----------------------------------------------------------------------------------------------
N
I
D
I
K
S
A
G
D
L
G
I
A
V
C
N
V
P
A
A
S
V
E
E
T
A
D
S
T
L
C
H
I
L
N
L
Y
R
R
A
T
W
L
H
Q
A
L
R
E
G
T
R
V
Q
S
V
E
Q
I
-
R
E
V
A
-
S
G
A
A
R
I
R
G
E
T
L
G
I
I
G
L
G
R
V
G
Q
A
V
A
L
R
A
K
A
F
G
F
N
V
L
F
Y
D
P
Y
L
S
D
G
---
V
E
R
A
L
G
L
---
Q
---
R
V
S
T
--------
L
Q
D
L
---
L
F
H
S
D
C
V
T
L
H
C
G
L
N
E
H
N
H
H
L
I
N
D
F
T
V
K
Q
M
R
Q
G
A
F
L
V
N
T
A
R
G
G
L
V
D
E
K
A
L
A
Q
A
L
K
E
G
R
I
R
G
A
A
L
D
V
H
E
S
E
P
-
F
---
S
F
S
Q
---
G
P
L
K
D
A
P
N
L
I
C
T
P
H
A
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
49.35
31%
-16
- C3 -
4U6Q
3
CTBP1_HUMAN
A:
[98-311]
-----------------------------------------------------------------------------------------------
N
I
D
I
K
S
A
G
D
L
G
I
A
V
C
N
V
P
A
A
S
V
E
E
T
A
D
S
T
L
C
H
I
L
N
L
Y
R
R
A
T
W
L
H
Q
A
L
R
E
G
T
R
V
Q
S
V
E
Q
I
-
R
E
V
A
-
S
G
A
A
R
I
R
G
E
T
L
G
I
I
G
L
G
R
V
G
Q
A
V
A
L
R
A
K
A
F
G
F
N
V
L
F
Y
D
P
Y
L
S
D
G
---
V
E
R
A
L
G
L
---
Q
---
R
V
S
T
--------
L
Q
D
L
---
L
F
H
S
D
C
V
T
L
H
C
G
L
N
E
H
N
H
H
L
I
N
D
F
T
V
K
Q
M
R
Q
G
A
F
L
V
N
T
A
R
G
G
L
V
D
E
K
A
L
A
Q
A
L
K
E
G
R
I
R
G
A
A
L
D
V
H
E
S
E
P
-
F
---
S
F
S
Q
---
G
P
L
K
D
A
P
N
L
I
C
T
P
H
A
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
48.65
31%
-14
- C3 -
4U6S
3
CTBP1_HUMAN
A:
[98-311]
-----------------------------------------------------------------------------------------------
N
I
D
I
K
S
A
G
D
L
G
I
A
V
C
N
V
P
A
A
S
V
E
E
T
A
D
S
T
L
C
H
I
L
N
L
Y
R
R
A
T
W
L
H
Q
A
L
R
E
G
T
R
V
Q
S
V
E
Q
I
-
R
E
V
A
-
S
G
A
A
R
I
R
G
E
T
L
G
I
I
G
L
G
R
V
G
Q
A
V
A
L
R
A
K
A
F
G
F
N
V
L
F
Y
D
P
Y
L
S
D
G
---
V
E
R
A
L
G
L
---
Q
---
R
V
S
T
--------
L
Q
D
L
---
L
F
H
S
D
C
V
T
L
H
C
G
L
N
E
H
N
H
H
L
I
N
D
F
T
V
K
Q
M
R
Q
G
A
F
L
V
N
T
A
R
G
G
L
V
D
E
K
A
L
A
Q
A
L
K
E
G
R
I
R
G
A
A
L
D
V
H
E
S
E
P
-
F
---
S
F
S
Q
---
G
P
L
K
D
A
P
N
L
I
C
T
P
H
A
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------