@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu18570: (2016-06-30 )
MRSFATQQNGIFKSVCSLDCPDQCGLLIHKKDGKIVKVQGDPDHPVTAGNICNKVRNMTERIYDEKRLTTPLKRTGAKGQAIFEPISWKEAIDTITSRWKQLIDEEGAESILPYSFYGNMGKLTAEGMDRRFFYRMGSSQLERTICSKAGSEGYKYTMGISAGIDPEETVHTKLFIFWGINAVSTNMHQITIAQKARKKGAKIVVIDVHKNQTGRLADWFIPIKPGTDSALALGIMHILFKENLHDEAFLSEYTVGYEELREHVKQYDPEKVSTITGVSTEDIYRLAKMYGETSPSFIRIGNGPQHHDNGGMIVRTIACLPAITGQWLHTGGGAIKHNSGILEYNTNALQRPDLLKGRTPRSFNMNQLGRVLLETDPPIRSLFIYGTNPAVVAPEANKVRQGLLREDLFTVVHDLFLTETAAYADIVLPATSAFENTDFYTSYWHHYIQLQQPVIERYGESKSNTEVFRLLAEAMGFTDQELKDSDEVLIRQALDHPDNPHLAEIDYDSLTKHSFMKAKREKPLFPGELPTPSGKIELYSEKMKQDGFPALPTYTPLVTDNEHPFMYVPGPNHNFLNSTFSNNEKHIKLEKTPKLFINTKDAEKHGIVDGAPVRIWNSRGECELTAAVGEQVLPGVVVSQGLWADEQGKKQLVNALTPDRLSDMGGGATFFSGRVQIEKV
Atome Classification :
(20 SA)
--------------------------------------.........10----....-....20--........30-..-------------------------------------------......40------.------....-..-------..50.........60...-----.-----....70....--.----------------------------------.---.-.80........90........100.......110....-----.-----.-.-120......--..130.-.-.--...----.140-------..--.....150.....------..-160........170........180..-----------.-.-..--.-190...-.---------------...-.------.----200.......210.....--------..220------.........230.......240.------......250..---------.----------------------------------------------------------------------.-------------------------------------------------------------------------------------------------...260---------------------------------------------------------------------------------------------------------------------------------------------------------....-.....270.......280.......290----..------.-----.-....-.300..-....--.310.......320.........330-----------------.....---...------------340-----------.---.---.---.----------------.-----------.--------.--------.------------350--....------------------------.---.------.----------------------.---------.------360------------.----------.------.---------------.-------------------.-.------.--------.--------------.------------370.------------.....-..380.......390.......400----------------------------.--.------------------------------.-.-.----..-..410.......-420.......430.......440-..--..--..--.450.......460.......470.....--..-------------480------------.---------..-------.-------------.--------.---------...490---------.----------------.--------------------------...-.-----.-----.-------------------------------------500---.---------------------..-----.....510---------------...---.-------------.--------------.-------.--------------------..--520--------------.-----.------.--------.----------..---..530-----.........540..-.-.-...550..-.-..-..--------------560-----..--.......570..-......--.--580.-...-.....590-....--...600.......610.......620--.....-.--.--630.......640....-------.-------.-----------.650-.......--660.---.----------------....--------------.670--------------..-.......680-----------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------------------MRSFATQQN
G
I
----
F
K
S
V
-CSLDC
P
--
D
QC
G
L
L
I
HKK-DG-------------------------------------------
K
I
V
K
V
QG-------D------PDHP-V
T
-------
A
G
N
-
I
C
N
K
V
R
N
M
T
E
R
I
Y
D-----E-----KRLTT
P
L
K
RT--G----------------------------------A---K-GQ
A
I
FEPI
S
W
K
E
A
I
D
T
I
T
S
R
W
K
Q
L
I
D
EEGAESILP
Y
S
F-----Y-----G-N-M-GK
L
T
A
EG--MD
R
R
F
F
-
Y
-R--M
G
S
----
S
Q
L
E
-------
R
T
--
I
C
S
KAGSEG
Y
K
Y
T
------
M
G-IS-AGIDPEE
T
V
H
-
T
K
L
F
I
F
WG
I
N
A
VS-----------T-N-
M
H
--
Q
-
I
--
T
I
A
-
Q
---------------
K
A
R-K------K----G
A
K
I
V
V
I
D
V
HKNQTGR
L
A
--------
D
W
F
--------
I
P
IKPGT
D
S
A
L
A
L
G
I
M
H
I
L
F
KEN------LH
D
E
A
F
L
S
E
YT---------V----------------------------------------------------------------------
G
-------------------------------------------------------------------------------------------------
Y
E
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
H
V
-
K
QYDPEKV
S
T
ITGV
S
T
E
D
I
Y
R
L
A
K
M
Y------GE------T-----S-P
S
F
I
-RIGNGP-QHHD--NG
G
M
I
V
R
T
I
ACL--PAI
T
G
Q
WLHTG------------------GGAIK---HNS------------
G
I
------------
L
---
E
---Y---N----------------T-----------N--------A--------L------------Q----RPDL------------------------L---K------G----------------------R---------T------P--------------R----------S------F---------------
N
-------------------
M
-
N
------
Q
--------
L
--------------
G
------------
R
V
-
L
------------LETDP-P
I
R
S
L
F
I
YGTNP
A
V
VAP
E
A
N
K
V
R
------------------------------
Q
--
G
------------------------------
L
-
L
-
R
----
E
D
-
L
F
T
V
V
H
D
L
F
LTE-TAA
Y
A
D
I
V
LPATSAFENT
D
F
Y
T
S
-
Y
W
--
H
H
--
Y
I
--
Q
L
Q
Q
P
V
I
E
RYGESKS
N
T
E
V
F
R
L
L
A
E
AMGF--
T
D
-------------
Q
--------------
E
---------LK-------D-------------
S
--------
D
---------
E
V
L
I
R
----------
Q
----------------
A
--------------------------LDH-P-----D-----N-------------------------------------P
H
----
L
---------------------
A
E-----I
D
Y
D
S
L
-----------------
T
K
H
---
S
-------------
F
--------------
M
-------
K
--------------------
A
K
--RE---------------K-----P------L--------F----------PG---ELP-------TPSG
K
I
E
L
Y
S
E
K
MK-Q-D-GFPALPTY-T-PL-VT--------------D-------NE--H
P
F
M
Y
VPG--PN-HNFLNS--T--F--S-NNE-
K
H
I
K
LEKT-
P
K
L
F
--
I
NTKD
A
E
KHGIVDGA
P
V
R
I
WNSRG
E
C
--
E
L
T
A
A
-V--G--EQVL
P
G
V
V
VSQGLWADE-------Q-------
G
-----------
K
K
Q
L
-
V
N
AL
T
P
D
--
R
L
S
D---M----------------GGG
A
--------------
T
F
----------------FS-
G
R
V
Q
I
E
KV-------------------
18
PsiBlast_PDB
72.00
25%
7
- C3 -
2V3V
9
NAPA_DESDA
A:
[10-702]
------------------------------------------------------
K
G
V
-
C
R
Y
-
C
G
--
T
G
C
G
V
L
V
G
V
K
-
D
G
-------------------------------------------
K
A
V
A
I
Q
G
-------
D
------
P
N
N
H
--
N
-------
A
G
L
-
L
C
L
K
G
S
L
L
I
P
V
L
N
S
-----
K
-----
E
R
V
T
Q
P
L
V
R
R
--
H
----------------------------------
K
---
G
-
G
K
--
L
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
---
A
W
-----
Y
-----
G
-
S
-
G
-
Q
C
L
T
E
E
S
Y
V
A
N
K
I
F
K
-
G
-
G
--
F
G
T
----
N
N
V
D
-------
G
N
PR
L
C
M
A
S
A
V
G
G
Y
V
T
S
FGKDEP
M
G
-
T
Y
-
A
D
I
D
--------
Q
A
T
C
F
F
I
I
G
S
N
T
-----------
S
-
E
-
A
H
--
P
-
V
--
L
F
R
-
R
---------------
I
A
R
-
R
------
K
Q
V
E
P
G
V
K
I
I
V
A
D
P
R
R
T
N
T
S
R
I
A
--------
D
M
H
--------
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
E
------
L
D
N
P
R
F
W
Q
R
Y
V
N
F
M
D
AEGKP
S
----------------------------------------------------------------------
D
-------------------------------------------------------------------------------------------------
F
E
G
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
F
L
-
E
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
A
F
------
A
E
------
S
-----
A
-
A
T
M
S
-
L
W
C
M
G
I
-
N
Q
R
V
--
Q
G
V
F
A
N
N
L
I
H
N
L
--
H
L
I
T
G
Q
I
C
R
P
G
ATS
F
S
L
T
G
Q
PNACGGVRD
G
G
A
L
S
---
H
L
L
------------
P
A
------------
G
---
R
---
A
---
I
----------------
P
-----------
N
--------
A
--------
K
------------
H
----
R
A
E
M
------------------------
E
---
K
L
W
GLPE
G
----------------------
R
---------
I
------
A
PE------------
P
----------
G
------
Y
---------------
H
-------------------
T
-
V
------
A
--------
L
--------------
F
------------
E
A
-
L
------------
G
R
G
D
---
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
L
N
K
V
H
------------------------------
K
--
A
------------------------------
M
-
S
-
H
----
P
E
-
S
F
I
V
C
I
E
A
F
P
D
A
V
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
-
G
E
--
R
R
--
Y
---
S
L
T
E
K
A
V
D
P
P
G
Q
C
R
P
T
V
N
T
L
V
E
F
A
R
R
A
G
V
--
D
P
-------------
Q
LV------------
N
---------
F
R
-------
N
-------------
A
--------
E
---------
D
V
W
N
E
----------
W
----------------
R
--------------------------
M
V
S
-
K
-----
G
-----
T
-------------------------------------
T
Y
----------------------------------
D
F
W
G
M
-----------------
T
R
E
---
R
-------------
L
--------------
R
-------
K
E
S
G
L
I
W
PCPSEDHPGTSLRY
V
R
--
G
Q
---------------
D
-----
P
------
C
--------
V
----------
P
A
---
D
H
P
DRFFFYG
K
P
D
G
R
A
V
I
W
M
R
P
A
K
-----
G
A
A
E
E
P
------------------------
D
-------
A
E
--
Y
P
-
L
Y
L
T
S
--
M
R
-
V
I
D
H
W
H
--
T
--
A
--
T
-
M
T
G
-
K
V
P
E
L
Q
K
A
N
P
I
A
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
H
G
D
S
V
I
V
E
T
R
R
D
A
M
--
E
L
P
A
R
-
V
--
S
--
D
V
C
R
P
G
L
I
A
V
P
F
F
-------------------
D
-----------
P
K
K
L
-
V
N
K
L
F
L
D
--------------------------------------------------------------------------------------------
16
PsiBlast_PDB
71.87
25%
9
- C3 -
2JIO
5
NAPA_DESDA
A:
[10-702]
------------------------------------------------------
K
G
V
-
C
R
Y
-
C
G
--
T
G
C
G
V
L
V
G
V
K
-
D
G
-------------------------------------------
K
A
V
A
I
Q
G
-------
D
------
P
N
N
H
--
N
-------
A
G
L
-
L
C
L
K
G
S
L
L
I
P
V
L
N
S
-----
K
-----
E
R
V
T
Q
P
L
V
R
R
--
H
----------------------------------
K
---
G
-
G
K
--
L
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
---
A
W
-----
Y
-----
G
-
S
-
G
-
Q
C
L
T
E
E
S
Y
V
A
N
K
I
F
K
-
G
-
G
--
F
G
T
----
N
N
V
D
-------
G
N
PR
L
C
M
A
S
A
V
G
G
Y
V
T
S
FGKDEP
M
G
-
T
Y
-
A
D
I
D
--------
Q
A
T
C
F
F
I
I
G
S
N
T
-----------
S
-
E
-
A
H
--
P
-
V
--
L
F
R
-
R
---------------
I
A
R
-
R
------
K
Q
V
E
P
G
V
K
I
I
V
A
D
P
R
R
T
N
T
S
R
I
A
--------
D
M
H
--------
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
E
------
L
D
N
P
R
F
W
Q
R
Y
V
N
F
M
D
AEG
K
P
S
----------------------------------------------------------------------
D
-------------------------------------------------------------------------------------------------
F
E
G
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
F
L
-
E
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
A
F
------
A
E
------
S
-----
A
-
A
T
M
S
-
L
W
C
M
G
I
-
N
Q
R
V
--
Q
G
V
F
A
N
N
L
I
H
N
L
--
H
L
I
T
G
Q
I
C
R
P
G
ATS
F
S
L
T
GQPNACGGVRD
G
G
A
L
S
---
H
L
L
------------
P
A
------------
G
---
R
---
A
---
I
----------------
P
-----------
N
--------
A
--------
K
------------
H
----
R
A
E
M
------------------------
E
---
K
L
W
GLPE
G
----------------------
R
---------
I
------
A
PE------------
P
----------
G
------
Y
---------------
H
-------------------
T
-
V
------
A
--------
L
--------------
F
------------
E
A
-
L
------------
G
R
G
D
---
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
L
N
K
V
H
------------------------------
K
--
A
------------------------------
M
-
S
-
H
----
P
E
-
S
F
I
V
C
I
E
A
F
P
D
A
V
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
-
G
E
--
R
R
--
Y
---
S
L
T
E
K
A
V
D
P
P
G
Q
C
R
P
T
V
N
T
L
V
E
F
A
R
R
A
G
V
--
D
P
-------------
Q
LV------------
N
---------
F
R
-------
N
-------------
A
--------
E
---------
D
V
W
N
E
----------
W
----------------
R
--------------------------
M
V
S
-
K
-----
G
-----
T
-------------------------------------
T
Y
----------------------------------
D
F
W
G
M
-----------------
T
R
E
---
R
-------------
L
--------------
R
-------
K
E
S
G
L
I
W
PCPSEDHPGTSLRY
V
R
--
G
Q
---------------
D
-----
P
------
C
--------
V
----------
P
A
---
D
H
P
DRFFFYG
K
P
D
G
R
A
V
I
W
M
R
P
A
K
-----
G
A
A
E
E
P
------------------------
D
-------
A
E
--
Y
P
-
L
Y
L
T
S
--
M
R
-
V
I
D
H
W
H
--
T
--
A
--
T
-
M
T
G
-
K
V
P
E
L
Q
K
A
N
P
I
A
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
H
G
D
S
V
I
V
E
T
R
R
D
A
M
--
E
L
P
A
R
-
V
--
S
--
D
V
C
R
P
G
L
I
A
V
P
F
F
-------------------
D
-----------
P
K
K
L
-
V
N
K
L
F
L
D
--------------------------------------------------------------------------------------------
49
Fugue
71.29
16%
0
- C- -
1G8K
6
AIOA_ALCFA
A:
[4-825]
ND
R
I
T
L
P
P
AN
A
Q
R
T
N
M
T
CHFCIVG
C
G
Y
H
V
Y
K
W
P
EL
E
E
G
G
R
A
P
E
Q
N
A
L
G
L
DFRK
Q
L
P
P
-
L
A
V
T
L
T
--
P
A
M
T
N
V
V
T
E
H
-
D
G
A
R
-----------------------------------------
Y
D
I
M
V
V
P
-------
D
------
K
A
C
V
-
V
N
-------
S
G
L
-
S
S
T
R
G
G
K
M
A
S
Y
M
Y
T
PTGDG
K
-----
E
R
L
S
A
P
R
L
Y
A
--
A
----------------------------------
D
---
E
-----
W
V
D
T
T
W
D
H
A
M
A
L
Y
A
G
L
I
K
K
T
L
D
K
D
G
P
Q
G
V
F
F
S
C
F
D----
H
-----
G
-
G
-
A
-
G
G
G
F
E
N
T
--
W
G
T
G
K
L
-
M
-
F
SA
I
Q
T
----
P
M
V
R
-------
I
H
NR
P
A
Y
N
S
E
C
H
A
T
R
E
-------
M
G
-
I
G
-
E
L
N
N
A
Y
E
D
A
Q
L
A
D
V
I
W
S
I
G
N
N
P
Y
E
SQ
T
N
Y
F
L
NH
W
L
P
-
N
-
L
Q
--
G
-
A
--
T
T
S
-
K
---------------
K
K
E
-
R
F
PN
E
N
F
P
----
Q
A
R
I
I
F
V
D
P
R
E
T
P
S
V
A
I
A
--------
R
H
V
AGNDRVLH
L
A
I
E
P
G
T
D
T
A
L
F
N
G
L
F
T
Y
V
V
E
Q
G
------
W
I
D
K
P
F
I
E
A
H
T
---------
K
----------------------------------------------------------------------
G
-------------------------------------------------------------------------------------------------
F
D
D
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
T
--
N
R
L
S
L
D
E
C
S
N
I
T
G
V
P
V
D
M
L
K
R
A
A
E
W
S
YKPKAS
G
Q
------
A
-----
P
-
R
T
M
H
-
A
Y
E
K
G
I
-
I
W
G
N
--
D
N
Y
V
I
Q
S
A
L
L
D
L
--
V
I
A
T
H
N
V
G
R
R
G
------------------
T
G
C
V
R
MGG
H
Q
E
------------
G
Y
------------
T
---
R
---
P
---
P
----------------
Y
-----------
P
--------
G
--------
D
------------
K
----
K
I
Y
I
------------------------
D
---
Q
------
E
----------------------
L
---------
I
------
K
--------------
G
----------
K
------
G
---------------
R
-------------------
I
-
M
------
T
--------
W
W
GCNNFQTSNN
A
Q
A
L
------------
R
E
-
A
------------
I
L
Q
R
S
-
A
I
V
K
Q
A
M
Q
K
A
R
G
A
T
T
E
E
M
V
D
V
I
Y
------------------------------
E
--
A
------------------------------
T
-
Q
-
N
----
G
G
-
L
F
V
T
S
I
N
L
Y
P
T
K
-
L
A
E
A
A
H
L
M
L
P
A
A
H
P
G
E
M
N
L
T
S
M
N
-
G
---
E
R
--
R
I
--
R
L
S
E
K
F
M
D
P
P
G
T
A
M
A
D
C
L
I
A
A
R
I
A
N
A
L
R
D
--
M
Y
-------------
Q
K
D
GK
A
E
M
A
A
Q
F
EGF
D
---------
W
K
-------
T
-------------
E
--------
E
---------
D
A
F
N
D
GFRRAGQPGA
P
----------------
A
--------------------------
I
D
S
-
Q
-----
G
-----
G
-------------------------------------
S
T
----
G
---------------------
H
L
-----
V
T
Y
D
R
L
-----------------
R
K
S
---
G
-------------
N
--------------
N
GVQLPVV
S
--------------------
W
D
--
E
S
---------------
K
-----
G
------
L
--------
V
----------
G
T
---
E
M
L
-------
Y
T
E
G
K
F
D
T
D
D
G
K
A
H
-
F
-
K
-
P
A
P
W
N
G
L
P
-
A
-
T
V
Q
Q
Q
--------------
K
-------
D
K
--
Y
R
F
W
L
N
N
G
--
R
N
-
N
E
V
W
Q
T
AY
H
--
D
--
Q
-
Y
N
S
-
L
M
Q
E
R
Y
P
M
-
A
Y
I
E
--
M
N
P
D
D
C
K
Q
L
D
V
T
G
G
D
I
V
E
V
Y
N
D
F
G
S
T
--
F
A
M
V
Y
-
P
--
V
--
A
E
I
K
R
G
Q
T
F
M
L
F
G
Y
------------------------------
V
N
G
I
-
Q
G
D
V
T
T
D
--
W
-
T
D
---
R
----------------
D
I
I
P
--------------
Y
Y
----------------
K
G
-
T
W
G
D
I
R
K
V
GSM
S
E
F
K
R
TVSFKSRRFG-
17
PsiBlast_PDB
70.68
25%
10
- C3 -
2JIQ
12
NAPA_DESDA
A:
[10-702]
------------------------------------------------------
K
G
V
-
C
R
Y
-
C
G
--
T
G
C
G
V
L
V
G
V
K
-
D
G
-------------------------------------------
K
A
V
A
I
Q
G
-------
D
------
P
N
N
H
--
N
-------
A
G
L
-
L
C
L
K
G
S
L
L
I
P
V
L
N
S
-----
K
-----
E
R
V
T
Q
P
L
V
R
R
--
H
----------------------------------
K
---
G
-
G
K
--
L
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
---
A
W
-----
Y
-----
G
-
S
-
G
-
Q
C
L
T
E
E
S
Y
V
A
N
K
I
F
K
-
G
-
G
--
F
G
T
----
N
N
V
D
-------
G
N
PR
L
C
M
A
S
A
V
G
G
Y
V
T
S
FGKDEP
M
G
-
T
Y
-
A
D
I
D
--------
Q
A
T
C
F
F
I
I
G
S
N
T
-----------
S
-
E
-
A
H
--
P
-
V
--
L
F
R
-
R
---------------
I
A
R
-
R
------
K
Q
V
E
P
G
V
K
I
I
V
A
D
P
R
R
T
N
T
S
R
I
A
--------
D
M
H
--------
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
E
------
L
D
N
P
R
F
W
Q
R
Y
V
N
F
M
D
AEGKP
S
----------------------------------------------------------------------
D
-------------------------------------------------------------------------------------------------
F
E
G
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
F
L
-
E
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
A
F
------
A
E
------
S
-----
A
-
A
T
M
S
-
L
W
C
M
G
I
-
N
Q
R
V
--
Q
G
V
F
A
N
N
L
I
H
N
L
--
H
L
I
T
G
Q
I
C
R
P
G
A
T
S
F
S
L
T
GQPNACGGVRD
G
G
A
L
S
---
H
L
L
------------
P
A
------------
G
---
R
---
A
---
I
----------------
P
-----------
N
--------
A
--------
K
------------
H
----
R
A
E
M
------------------------
E
---
K
L
W
GLPE
G
----------------------
R
---------
I
------
A
PE------------
P
----------
G
------
Y
---------------
H
-------------------
T
-
V
------
A
--------
L
--------------
F
------------
E
A
-
L
------------
G
R
G
D
---
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
L
N
K
V
H
------------------------------
K
--
A
------------------------------
M
-
S
-
H
----
P
E
-
S
F
I
V
C
I
E
A
F
P
D
A
V
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
-
G
E
--
R
R
--
Y
---
S
L
T
E
K
A
V
D
P
P
G
Q
C
R
P
T
V
N
T
L
V
E
F
A
R
R
A
G
V
--
D
P
-------------
Q
LV------------
N
---------
F
R
-------
N
-------------
A
--------
E
---------
D
V
W
N
E
----------
W
----------------
R
--------------------------
M
V
S
-
K
-----
G
-----
T
-------------------------------------
T
Y
----------------------------------
D
F
W
G
M
-----------------
T
R
E
---
R
-------------
L
--------------
R
-------
K
E
S
G
L
I
W
PCPSEDHPGTSLRY
V
R
--
G
Q
---------------
D
-----
P
------
C
--------
V
----------
P
A
---
D
H
P
DRFFFYG
K
P
D
G
R
A
V
I
W
M
R
P
A
K
-----
G
A
A
E
E
P
------------------------
D
-------
A
E
--
Y
P
-
L
Y
L
T
S
--
M
R
-
V
I
D
H
W
H
--
T
--
A
--
T
-
M
T
G
-
K
V
P
E
L
Q
K
A
N
P
I
A
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
H
G
D
S
V
I
V
E
T
R
R
D
A
M
--
E
L
P
A
R
-
V
--
S
--
D
V
C
R
P
G
L
I
A
V
P
F
F
-------------------
D
-----------
P
K
K
L
-
V
N
K
L
F
L
D
--------------------------------------------------------------------------------------------
20
PsiBlast_PDB
70.36
24%
7
- C3 -
2JIM
5
NAPA_DESDA
A:
[10-702]
------------------------------------------------------
K
G
V
-
C
R
Y
-
C
G
--
T
G
C
G
V
L
V
G
V
K
-
D
G
-------------------------------------------
K
A
V
A
I
Q
G
-------
N
------
P
N
N
H
--
N
-------
A
G
L
-
L
C
L
K
G
S
L
L
I
P
V
L
N
S
-----
K
-----
E
R
V
T
Q
P
L
V
R
R
--
H
----------------------------------
K
---
G
-
G
K
--
L
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
---
A
W
-----
Y
-----
G
-
S
-
G
-
Q
C
L
T
E
E
S
Y
V
A
N
K
I
F
K
-
G
-
G
--
F
G
T
----
N
N
V
D
-------
G
N
PR
L
C
M
A
S
A
V
G
G
Y
V
T
S
FGKDEP
M
G
-
T
Y
-
A
D
I
D
--------
Q
A
T
C
F
F
I
I
G
S
N
T
-----------
S
-
E
-
A
H
--
P
-
V
--
L
F
R
-
R
---------------
I
A
R
-
R
------
K
Q
V
EP
G
V
K
I
I
V
A
D
P
R
R
T
N
T
S
R
I
A
--------
D
M
H
--------
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
E
------
L
D
N
P
R
F
W
Q
R
Y
V
N
F
M
D
AEG
K
P
S
----------------------------------------------------------------------
D
-------------------------------------------------------------------------------------------------
F
E
G
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
F
L
-
E
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
A
F
------
A
E
------
S
-----
A
-
A
T
M
S
-
L
W
C
M
G
I
-
N
Q
R
V
--
Q
G
V
F
A
N
N
L
I
H
N
L
--
H
L
I
T
G
Q
I
C
R
P
G
A
T
S
F
S
L
T
G
Q
PNACGGVRD
G
G
A
L
S
---
H
L
L
------------
P
A
------------
G
---
R
---
A
---
I
----------------
P
-----------
N
--------
A
--------
K
------------
H
----
R
A
E
M
------------------------
E
---
K
L
W
GLPE
G
----------------------
R
---------
I
------
A
PE------------
P
----------
G
------
Y
---------------
H
-------------------
T
-
V
------
A
--------
L
--------------
F
------------
E
A
-
L
------------
G
R
G
D
---
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
L
N
K
V
H
------------------------------
K
--
A
------------------------------
M
-
S
-
H
----
P
E
-
S
F
I
V
C
I
E
A
F
P
D
A
V
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
-
G
E
--
R
R
--
Y
---
S
L
T
E
K
A
V
D
P
P
G
Q
C
R
P
T
V
N
T
L
V
E
F
A
R
R
A
G
V
--
D
P
-------------
Q
LV------------
N
---------
F
R
-------
N
-------------
A
--------
E
---------
D
V
W
N
E
----------
W
----------------
R
--------------------------
M
V
S
-
K
-----
G
-----
T
-------------------------------------
T
Y
----------------------------------
D
F
W
G
M
-----------------
T
R
E
---
R
-------------
L
--------------
R
-------
K
E
S
G
L
I
W
PCPSEDHPGTSLRY
V
R
--
G
Q
---------------
D
-----
P
------
C
--------
V
----------
P
A
---
D
H
P
DRFFFYG
K
P
D
G
R
A
V
I
W
M
R
P
A
K
-----
G
A
A
E
E
P
------------------------
D
-------
A
E
--
Y
P
-
L
Y
L
T
S
--
M
R
-
V
I
D
H
W
H
--
T
--
A
--
T
-
M
T
G
-
K
V
P
E
L
Q
K
A
N
P
I
A
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
H
G
D
S
V
I
V
E
T
R
R
D
A
M
--
E
L
P
A
R
-
V
--
S
--
D
V
C
R
P
G
L
I
A
V
P
F
F
-------------------
D
-----------
P
K
K
L
-
V
N
K
L
F
L
D
--------------------------------------------------------------------------------------------
5
PsiBlast_PDB
69.78
25%
22
- C3 -
2E7Z
8
AHY_PELAE
A:
[9-680]
----------------------------------------------------------
C
D
I
N
C
V
--
V
E
A
E
V
---
K
A
-
D
G
-------------------------------------------
K
I
Q
T
K
S
I
-------
S
------
E
P
H
P
-
T
T
-------
P
P
N
S
I
C
M
K
S
V
N
A
D
T
I
R
T
H
-----
K
-----
D
R
V
L
Y
P
L
K
N
V
--
G
----------------------------------
S
---
K
R
G
E
Q
R
W
E
R
I
S
W
D
Q
A
L
D
E
I
A
E
K
L
K
K
I
I
A
K
Y
G
P
E
S
L
G
V
S
Q
------------
T
-
E
-
I
-
N
Q
Q
S
E
Y
G
--
T
L
R
R
F
M
-
N
-
L
--
L
G
S
PNWT
S
A
M
Y
-------
M
C
--
I
G
N
T
A
G
V
--
H
R
V
T
------
H
G
-
S
Y
-
S
F
A
S
---
F
A
D
-
S
N
C
L
L
F
I
G
K
N
L
S
N
-----------
H
-
N
W
V
S
--
Q
-
F
--
N
D
L
-
K
---------------
A
A
L
-
K
------
R
----
G
C
K
L
I
V
L
D
P
R
R
T
K
V
A
E
M
A
--------
D
I
W
--------
L
P
L
R
Y
G
T
D
A
A
L
F
L
G
M
I
N
V
I
I
N
E
Q
------
L
Y
D
K
E
F
V
E
N
W
C
---------
V
----------------------------------------------------------------------
G
-------------------------------------------------------------------------------------------------
F
E
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
R
V
-
Q
E
Y
P
L
D
K
V
A
E
I
T
G
C
D
A
G
E
I
R
K
A
A
V
M
F
------
A
T
------
E
-----
S
-
P
A
S
I
-
P
W
A
V
S
T
-
D
M
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K
--
N
S
C
S
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L
--
R
A
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G
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I
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A
PHSDLVP
I
S
K
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M
H
E
A
L
P
---
E
E
K
------------
K
K
------------
L
---
Q
---
L
---
G
----------------
T
ETYPFLTYTGM
S
--------
A
--------
L
------------
E
----
E
P
S
E
------------------------
R
---
V
------
Y
----------------------
G
---------
V
------
K
--------------
Y
----------
F
------
H
---------------
N
-------------------
M
-
G
------
A
FMAN
P
T
A
L
F
--------------
T
------------
A
M
-
A
------------
T
E
K
P
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-
P
V
K
A
F
F
A
L
A
S
N
A
L
M
G
Y
A
N
Q
Q
N
A
L
------------------------------
K
--
G
------------------------------
L
-
M
-
N
----
Q
D
-
L
-
V
V
C
Y
D
Q
F
M
T
P
-
T
A
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L
A
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L
P
G
D
H
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L
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P
V
V
Q
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N
--
W
--
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G
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F
G
--
N
T
S
Q
Q
V
V
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A
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K
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L
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L
--
E
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-------------
H
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P
---------
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K
-------
D
-------------
R
--------
L
---------
E
L
---------------------------------------------------------
I
N
Y
-
R
-----
I
-----
S
-------------------------------------
P
---------------------------
T
G
-----
M
E
W
E
E
Y
-----------------
Q
K
Q
---
Y
-------------
T
--------------
Y
-------
M
--------------------
S
K
--
L
P
---------------
D
-----
Y
------
F
--------
G
----------
P
E
GV-
G
V
A
-------
T
P
S
G
K
V
E
L
Y
S
S
V
F
E
-
K
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L
-
G
Y
D
P
L
P
Y
Y
H
E
-
P
L
-
Q
T
--------------
E
ISD
P
E
L
A
K
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--
Y
P
L
I
L
F
A
G
LR
E
D
-
S
N
F
-
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--
C
--
Y
--
H
-
Q
P
G
-
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L
R
D
A
E
P
D
-
P
V
A
L
--
L
H
P
K
T
A
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L
G
L
P
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W
V
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T
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G
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K
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L
L
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--
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--
A
Q
P
E
G
T
I
R
I
P
H
G
R
W
C
P
E
-------
Q
---------------------------------------------------------------------------------------------------------------------------
21
HHSearch
69.61
25%
21
- C3 -
2E7Z
8
AHY_PELAE
A:
[1-727]
------------------------------------------------
K
----
K
H
V
V
-
C
Q
-
S
C
D
--
I
N
C
V
V
E
A
E
V
K
A
D
G
-------------------------------------------
K
I
Q
T
K
S
I
-------
S
------
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P
H
P
T
T
P
-------
P
N
S
-
I
C
M
K
S
V
N
A
D
T
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R
T
H
-----
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-----
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R
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L
Y
P
L
K
N
V
--
G
S---------------------------------
K
---
R
-
G
E
Q
R
W
E
R
I
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W
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L
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K
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K
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G
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L
G
V
S
Q
T
-----
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-----
I
-
N
Q
Q
-
S
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Y
G
-----
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L
R
R
F
M
-
N
-
L
--
L
G
S
----
P
N
W
T
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M
Y
--
M
C
I
G
N
T
A
G
V
H
R
V
T
------
H
G
-----
S
Y
S
F
A
S
F
A
D
-
S
N
C
L
L
F
I
G
K
N
L
S
N
-----------
H
-
N
-
W
V
--
S
Q
F
--
N
D
L
-
K
---------------
A
A
L
-
K
------
R
----
G
C
K
L
I
V
L
D
P
R
R
T
K
V
A
E
M
A
--------
D
I
W
--------
L
P
L
R
Y
G
T
D
A
A
L
F
L
G
M
I
N
V
I
I
N
E
Q
------
L
Y
D
K
E
F
V
E
N
W
C
---------
V
----------------------------------------------------------------------
G
-------------------------------------------------------------------------------------------------
F
E
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
R
V
-
Q
E
Y
P
L
D
K
V
A
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G
C
D
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G
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K
A
A
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M
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------
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------
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-----
S
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P
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G
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F
V
N
-
G
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A
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---
A
P
H
------------
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D
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P
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---
Q
MHE
A
LP
E
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K
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K
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L
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--------
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--------
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T
----
Y
P
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L
------------------------
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T
------
G
----------------------
M
SAL
E
E
P
S
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R
V
------
Y
--------------
G
VKYF------
H
NMGAFM
A
---------------
N
-------------------
P
-
T
------
A
--------
L
--------------
F
------------
T
A
-
M
A
-----------
T
E
K
P
Y
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P
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K
A
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A
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A
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N
A
L
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G
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Q
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N
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A
------------------------------
L
--
K
------------------------------
G
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L
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----
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Q
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V
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-
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---
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G
--
I
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A
V
R
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--
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-------------
H
--------------
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---------
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-------
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---------
L
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L
I
N
----------
Y
----------------
R
--------------------------
I
S
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P
---------------------
T
G
-----
M
E
W
E
E
Y
-----------------
Q
K
Q
---
Y
-------------
T
Y
-------------
M
-------
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--------------------
K
L
--
P
D
---------------
Y
F----
G
------
P
--------
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----------
G
V
---
G
V
A
-------
T
P
S
G
K
V
E
L
Y
S
S
V
F
E
-
K
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L
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G
Y
D
P
L
P
Y
Y
-
H
-
E
P
-
L
Q
TEISD
P
E
L
------
A
-------
K
E
--
Y
P
L
I
L
F
A
G
--
L
R
E
D
S
N
F
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--
C
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--
H
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--
G
A
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P
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G
T
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H
G
R
W
C
P
-------
E
-------
Q
EGGPETGFSGA
M
L
H
N
D
A
M
V
L
S
D
D
DW
N
L
D
P
---
E
----------------
Q
G
L
P
--------------
N
L
----------------
R
G
G
I
L
A
K
A
Y
K
C
-------------------
19
PsiBlast_PDB
69.50
24%
9
- C3 -
2NAP
5
NAPA_DESDA
A:
[10-702]
------------------------------------------------------
K
G
V
-
C
R
Y
-
C
G
--
T
G
C
G
V
L
V
G
V
K
-
D
G
-------------------------------------------
K
A
V
A
I
Q
G
-------
N
------
P
N
N
H
--
N
-------
A
G
L
-
L
C
L
K
G
S
L
L
I
P
V
L
N
S
-----
K
-----
E
R
V
T
Q
P
L
V
R
R
--
H
----------------------------------
K
---
G
-
G
K
--
L
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P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
---
A
W
-----
Y
-----
G
-
S
-
G
-
Q
C
L
T
E
E
S
Y
V
A
N
K
I
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K
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G
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G
--
F
G
T
----
N
N
V
D
-------
G
N
PR
L
C
M
A
S
A
V
G
G
Y
V
T
S
FGKDEP
M
G
-
T
Y
-
A
D
I
D
--------
Q
A
T
C
F
F
I
I
G
S
N
T
-----------
S
-
E
-
A
H
--
P
-
V
--
L
F
R
-
R
---------------
I
A
R
-
R
------
K
Q
V
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G
V
K
I
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V
A
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R
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R
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M
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--------
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L
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M
A
W
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I
I
N
E
E
------
L
D
N
P
R
F
W
Q
R
Y
V
N
F
M
D
AEGKP
S
----------------------------------------------------------------------
D
-------------------------------------------------------------------------------------------------
F
E
G
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
F
L
-
E
N
Y
R
P
E
K
V
A
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C
R
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P
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G
A
A
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A
F
------
A
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------
S
-----
A
-
A
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S
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L
W
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M
G
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N
Q
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--
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L
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F
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GQPNACGGVRD
G
G
A
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---
H
L
L
------------
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------------
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---
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---
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---
I
----------------
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-----------
N
--------
A
--------
K
------------
H
----
R
A
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------------------------
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---
K
L
W
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G
----------------------
R
---------
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------
A
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P
----------
G
------
Y
---------------
H
-------------------
T
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V
------
A
--------
L
--------------
F
------------
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A
-
L
------------
G
R
G
D
---
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
L
N
K
V
H
------------------------------
K
--
A
------------------------------
M
-
S
-
H
----
P
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F
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V
C
I
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A
F
P
D
A
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L
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A
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L
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P
A
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G
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-
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R
--
Y
---
S
L
T
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K
A
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P
P
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V
N
T
L
V
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A
R
R
A
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--
D
P
-------------
Q
LV------------
N
---------
F
R
-------
N
-------------
A
--------
E
---------
D
V
W
N
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----------
W
----------------
R
--------------------------
M
V
S
-
K
-----
G
-----
T
-------------------------------------
T
Y
----------------------------------
D
F
W
G
M
-----------------
T
R
E
---
R
-------------
L
--------------
R
-------
K
E
SGLIWPCPSEDHPGTSLRY
V
R
--
G
Q
---------------
D
-----
P
------
C
--------
V
----------
P
A
---
D
H
P
DRFFFYG
K
P
D
G
R
A
V
I
W
M
R
P
A
K
-----
G
A
A
E
E
P
------------------------
D
-------
A
E
--
Y
P
-
L
Y
L
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M
R
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I
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H
W
H
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M
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K
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A
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L
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P
F
F
-------------------
D
-----------
P
K
K
L
-
V
N
K
L
F
L
D
--------------------------------------------------------------------------------------------
31
HHSearch
69.39
22%
27
- C3 -
2IVF
11
?
A:
[80-976]
------------------------------------------------------
G
S
H
-
L
N
-
I
C
W
PQ
G
S
C
K
F
Y
V
Y
V
R
-
N
G
-------------------------------------------
I
V
W
R
E
E
Q
-------
A
------
A
Q
T
P
-
A
C
NVDYVDY
N
P
L
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G
C
Q
K
G
S
A
F
N
N
N
L
Y
G
-----
D
-----
E
R
V
K
Y
P
L
K
R
V
--
G
----------------------------------
K
---
R
-
G
E
G
K
W
K
R
V
S
W
D
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A
A
G
D
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I
I
D
S
F
E
A
Q
G
S
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G
F
I
L
D
A
P
HVHAG
S
-----
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A
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W
-
G
A
G
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-----
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M
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--
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S
-----
P
D
I
---------
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--
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D
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D
T
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M
G
A
F
H
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------
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G
K
M
H
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M
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S
A
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N
L
L
D
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A
E
L
I
F
M
T
C
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N
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Y
-----------
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--
S
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--
H
F
L
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---------------
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---------
D
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L
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R
MDTGKFLSAEDVDGGEAK
Q
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S
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RGTLKLDFMPAL
E
G
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F
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A
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K
T
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Q
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R
T
V
-------------------------------------------------------------------------------------------------
F
E
G
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
R
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L
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A
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L
G
R
K
V
------
A
K
------
K
-------
R
T
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S
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Y
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G
F
S
S
-
A
K
S
Y
--
H
G
D
L
M
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S
L
F
L
A
--
M
A
L
S
G
N
W
G
K
P
G
------------------
T
G
A
F
A
---
W
A
Y
SD
D
N
M
V
Y
L
G
VMS
K
P
------------
T
A--
Q
---
G
---
G
----------------
M
-----------
D
E
-------
L
--------
H
Q
M
A
E
G
F
N
K
R
T
L
E
A
----
D
P
T
S
------------------------
T
---
D
E
M
----
G
N
I
--------------------
E
F
M
K
V
V
T
S
--
A
------
V
--------------
G
----------
L
------
V
---------------
P
P
A
M
W
L
Y
Y
HVG---------
Y
-
D
Q
L
W
N
NK
A
--------
W
--------------
T
DPALKKS
F
G
A
Y
L
D
E
A
K
E
K
GWWTNDHIR-
P
A
P
D
K
-
T
P
Q
V
Y
M
L
L
S
Q
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P
M
R
R
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R
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G
A
K
-
M
------------------------------
F
P
D
V
------------------------------
L
-
F
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P
----
K
L
-
K
M
I
F
A
L
E
T
R
M
S
S
-
S
A
M
Y
A
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I
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L
P
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A
W
Y
Y
E
K
H
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M
T
T
P
-
C
S
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N
P
--
F
F
--
T
F
V
D
R
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V
A
P
P
G
E
C
R
E
E
W
D
A
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A
L
I
L
K
K
V
G
E
--
R
A
A
A
R
GL
T
E
------
F
--------------
N
---------
D
H
NG
R
K
R
R
Y
D
E
L
Y
K
K
F
T
M
DGHLL
T
--------
N
---------
E
D
C
L
K
----------
E
----------------
M
--------------------------
V
D
I
N
R
-----
A
-----
V
G------------------------------------
V
F
----
A
---------------------
K
D
-----
Y
T
Y
E
K
F
-----------------
K
K
E
---
G
-------------
Q
--------------
T
R------
F
--------------------
L
S
--
M
G
TGVSRYAHA
N
E
V
D
VT
K
-----
P
------
I
Y
P
MRWHFD
D
----------
K
K
---
V
F
P
-------
T
H
T
R
R
A
Q
F
Y
L
D
H
D
W
Y
L
-
E
-
A
G
E
S
L
P
T
H
-
K
-
D
T
-
P
M
V-------------
G
-------
G
D
--
H
P
F
K
I
T
G
G
--
H
P
-
R
V
S
I
H
S
--
T
--
H
--
L
-
T
N
S
-
H
L
S
R
L
H
R
G
Q
P
V
V
H
--
M
N
S
K
D
A
A
E
L
G
I
K
D
G
D
M
A
K
L
F
N
D
F
A
D
C
--
E
I
M
V
R
-
T
--
A
--
P
N
V
Q
P
K
Q
C
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V
Y
F
W
D
A
H
Q
-------
Y
-------
K
-----------
G
W
K
P
-
Y
D
I
L
L
I
G
--
M
P
K
P
LHL
A
----------------
G
G
Y
E
QFRYYFMNGSPAPV
T
D
----------------
R
G
-
V
R
V
S
I
K
K
A
-------------------
22
HHSearch
68.66
23%
2
- C3 -
2VPZ
4
?
A:
[32-744]
-----------------------------------------
W
Y
A
Q
E
V
K
S
----
V
Y
Q
I
-
C
E
-
G
C
F
--
W
R
C
G
I
V
A
H
A
V
-
G
N
-------------------------------------------
R
V
Y
K
V
E
G
-------
Y
------
E
A
N
P
-
K
S
-------
R
G
R
-
L
C
P
R
G
Q
G
A
P
Q
T
T
Y
D
-----
P
-----
D
R
L
K
R
P
L
I
R
V
--
E
GS--------------------------------
Q
---
R
-
G
E
G
K
Y
R
V
A
T
W
E
E
A
L
D
H
I
A
K
K
M
L
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Y
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P
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A
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A
F
F
G
H
-----
G
-----
T
---
G
--
D
-
Y
-----
W
F
V
D
F
L
P
A
-
A
--
W
G
S
----
P
N
A
A
KPS----
V
S
--
L
C
T
A
P
R
E
V
A
S
Q
W
V
------
F
G
R
P
I
-
G
G
H
E
P
I
D
W
E
N
-
A
R
Y
I
V
L
I
G
H
H
I
G
E
-----------
D
T
H
-
N
T
--
Q
-
L
--
Q
D
F
-
A
---------------
L
A
L
-
K
------
N
----
G
A
K
V
V
V
V
D
P
R
F
S
T
A
A
A
K
A
--------
H
R
W
--------
L
P
I
K
P
G
T
D
T
A
L
L
L
A
W
I
H
V
L
I
Y
E
D
------
L
Y
D
K
E
Y
V
A
K
Y
T
---------
V
----------------------------------------------------------------------
G
-------------------------------------------------------------------------------------------------
F
E
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
H
V
-
K
D
F
T
P
E
W
A
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K
H
T
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P
A
Q
V
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R
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V
A
R
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M
------
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A
------
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V
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L
P
P
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R
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N
V
W
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G
--
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M
A
L
L
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V
--
N
V
L
L
G
N
Y
G
R
P
G
------------------
G
F
Y
I
A
---
Q
S
P
------------
Y
L
E
K
YPLPPLP
L
E
P
A
A--
G
---
G
---
C
----------------
S
-----------
G
PSGGDHEP
E
--------
G
------------
F
----
K
P
R
A
------------------------
D
---
K
------
G
----------------------
K
---------
F
------
F
A-------------
R
----------
S
------
T
---------------
A
-------------------
I
-
Q
------
E
--------
L
--------------
I
------------
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P
-
M
I
-----------
T
G
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P
Y
-
P
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K
G
L
F
A
Y
G
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N
L
F
H
S
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P
N
V
P
R
-
T
------------------------------
K
--
E
------------------------------
A
-
L
-
K
----
N
L
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D
L
Y
V
A
I
D
V
L
P
Q
E
-
H
V
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W
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A
HK
T
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--
F
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--
Q
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A
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P
L
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T
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P
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W
W
I
A
R
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L
G
L
R
L
G
L
--
E
Q
-------------
Y
--------------
F
---------
P
W
-------
K
-------------
T
--------
I
---------
E
E
Y
L
E
----------
T
----------------
R
--------------------------
L
Q
S
-------------------------------------------------------------------------------
L
G
-----
L
D
L
E
T
M
-----------------
K
G
M
---
G
-------------
T
--------------
L
-------
V
--------------------
Q
R
G
K
P
W
L
--------------
E
-----
D
------
W
E
K
E
-----
G
----------
R
L
---
P
F
G
-------
T
A
S
G
K
I
E
L
Y
C
Q
R
F
K
-
E
-
A
-
G
H
Q
P
L
P
V
F
-
T
-
P
P
-
E
E
--------------
P
-------
P
E
--
G
F
Y
R
L
L
Y
G
--
R
S
-
P
V
H
T
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A
--
R
--
T
--
Q
-
N
N
W
-
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L
M
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D
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P
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I
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A
R
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Y
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G
F
G
H
K
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PLMRLAH
G
-----------
R
G
A
S
-
D
N
Y
L
Q
T
R
Y
-
K
L
D
P
---
I
----------------
S
G
G
A
--------------
G
L
----------------
R
V
-
N
F
V
R
L
E
K
A
-------------------
4
PsiBlast_PDB
68.33
24%
21
- C3 -
2VPZ
4
?
A:
[33-674]
-----------------------------------------
Y
A
Q
E
V
K
S
V
----
Y
Q
-
I
-
C
E
-
G
C
F
--
W
R
C
G
I
V
A
H
A
V
-
G
N
-------------------------------------------
R
V
Y
K
V
E
G
-------
Y
------
E
A
N
P
-
K
S
-------
R
G
R
-
L
C
P
R
G
Q
G
A
P
Q
T
T
Y
D
-----
P
-----
D
R
L
K
R
P
L
I
R
V
EG
S
----------------------------------
Q
---
R
-
G
E
G
K
Y
R
V
A
T
W
E
E
A
L
D
H
I
A
K
K
M
L
E
I
R
E
K
Y
G
P
E
A
I
---
A
F
-----
F
-----
G
-
H
G
T
-
G
D
Y
W
F
V
D
--
F
L
P
A
A
W
-
G
-
S
--
P
N
A
----
A
K
P
S
-------
V
S
--
L
C
T
A
P
R
E
V
A
S
Q
W
V
------
F
G
-
R
P
I
G
G
H
E
P
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D
W
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N
-
A
R
Y
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V
L
I
G
-
H
H
I
G
-----------
E
-
D
-
T
H
N
T
Q
-
L
--
Q
D
F
-
A
---------------
L
A
L
-
K
------
N
----
G
A
K
V
V
V
V
D
P
R
F
S
T
A
A
A
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A
--------
H
R
W
--------
L
P
I
K
P
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T
D
T
A
L
L
L
A
W
I
H
V
L
I
Y
E
D
------
L
Y
D
K
E
Y
V
A
K
Y
T
---------
V
----------------------------------------------------------------------
G
-------------------------------------------------------------------------------------------------
F
E
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
H
V
-
K
D
F
T
P
E
W
A
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K
H
T
E
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P
A
Q
V
I
R
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V
A
R
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M
------
A
A
------
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-----
K
-
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----
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L
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P
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T
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N
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Y
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D
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M
A
L
L
Y
V
N
V
L
L
G
N
Y
G
R
P
G
------------------
G
F
Y
I
A
---
Q
S
P
------------
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L
------------
E
---
K
---
Y
---
P
LPPLP
L
E
P
A
AGGCSGP
S
-----------
G
--------
G
--------
D
------------
H
----
E
P
E
G
------------------------
F
---
K
------
P
----------------------
R
---------
A
DKGKFF
A
--------------
R
----------
S
------
T
---------------
A
-------------------
I
-
Q
------
E
--------
L
--------------
I
------------
E
P
-
M
------------
I
T
G
E
P
Y
P
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K
G
L
F
A
Y
G
I
N
L
F
H
S
I
P
N
V
P
R
T
K
------------------------------
E
--
A
------------------------------
L
-
K
-
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----
L
D
-
L
Y
V
A
I
-
D
V
L
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E
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M
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A
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L
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--
H
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T
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--
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A
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W
W
I
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L
G
L
R
L
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L
--
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Q
-------------
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--------------
F
---------
P
W
-------
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-------------
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--------
I
---------
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E
Y
L
E
----------
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----------------
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--------------------------
L
Q
S
-------------------------------------------------------------------------------
L
G
-----
L
D
L
E
T
M
-----------------
K
G
M
---
G
-------------
T
--------------
L
----------------------------
V
Q
--
R
G
---------------
K
-----
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------
W
--------
L
E
D
W
E
K
-----
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G
---
R
L
P
F
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T
A
S
G
K
I
E
L
Y
C
Q
R
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K
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A
-
G
H
Q
P
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P
V
F
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T
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P
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--------------
P
-------
P
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G
F
Y
R
L
L
Y
G
R
S
--
P
V
-
H
T
F
A
R
T
--------
Q
-
N
N
W
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L
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P
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N
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H
K
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A
K
R
L
G
L
K
E
G
D
Y
V
M
L
V
N
Q
D
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
68.21
24%
24
* C3 *
4YDD
10
?
A:
[19-891]
---------------------------------------
R
T
Q
W
S
W
D
K
K
T
----
R
G
A
H
-
L
V
-
N
C
T
--
G
A
C
P
H
F
V
Y
S
K
-
D
G
-------------------------------------------
V
V
M
R
E
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Q
-------
S
KDIAPM
P
N
I
P
-
E
Y
-------
N
P
R
-
G
C
N
K
G
E
C
G
H
D
Y
M
Y
G
-----
P
-----
H
R
I
K
Y
P
L
I
R
V
--
G
----------------------------------
E
---
R
-
G
E
G
K
W
R
R
A
T
W
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E
A
L
D
M
I
A
D
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C
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D
T
I
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N
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A
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D
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I
S
V
Y
S
P
-----
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-----
P
-
A
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--
A
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----
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------
C
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L
W
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S
N
P
T
Q
-----------
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F
L
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---------------
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A
Q
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------
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----
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A
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--------
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T
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A
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------
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Y
D
A
H
S
L
K
E
Q
T
---------
D
----------------------------------------------------------------------
L
S
Y
L
V
R
SDTKRFLREADVVAGGSKD
K
F
Y
F
W
NAKTG
K
P
V
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K
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L
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K
T
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-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
S
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N
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P
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K
A
A
K
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G
V
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A
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A
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T
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L
A
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------
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------
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-----
K
-
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-
I
C
G
G
G
T
-
Q
H
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--
Y
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L
L
R
A
M
H
L
L
--
T
A
L
T
G
T
E
G
T
N
G
------------------
G
G
M
N
H
---
Y
I
G
------------
Q
W
------------
K
P--
A
F
V
A
G
---
L
----------------
V
-----------
A
--------
L
---------------------
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----
F
P
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------------------------
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---
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------
K
Q
---------------------
R
F
C
Q
T
T
----
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------
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--------------
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Y
---------
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------
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A
EVNDEIISSDID
T
E
K
Y
------------------
L
R
D
------
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--------
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--------------
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-----------
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Q
-
M
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---------
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N
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L
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------------------------------
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--
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------------------------------
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-
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----
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L
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V
D
I
N
I
R
M
D
S
-
T
A
L
Y
S
D
V
V
L
P
S
A
H
W
Y
E
K
L
D
L
N
V
T
-
S
E
--
H
S
--
Y
I
--
N
M
T
E
P
A
I
K
P
M
W
E
S
K
T
D
W
Q
I
F
L
A
L
A
K
R
V
E
M
--
A
A
K
R
K
K---------
Y
--------------
E
---------
K
F
-------
N
-------------
D
EKFKWVRD
L
---------
S
N
L
W
N
----------
Q
M
T
M
DGKLAE
D
E
A
A
A
Q
Y
I
--------------------------
L
D
N
-
A
-------------------------------------------------
P
Q
----
S
---------------------
K
G
-----
I
T
I
Q
M
L
-----------------
R
E
K
---
P
-------------
Q
--------------
R
F
KSN---
W
--------------------
T
S
--
P
L
K
EG------------
V
-----
P
------
Y
T
P
FQYFVV
D
----------
K
K
---
P
W
P
-------
T
L
T
G
R
Q
Q
F
Y
L
D
H
D
T
-
F
-
F
D
M
G
V
E
L
P
T
Y
-
K
-
A
P
-
I
D
--------------
A
-------
D
K
--
Y
P
F
R
F
N
S
P
--
H
S
-
R
H
S
V
H
S
--
T
--
F
--
K
D
N
V
L
-
M
L
R
L
Q
-
R
G
G
P
S
I
E
--
M
S
P
L
D
A
K
P
L
G
I
K
D
N
D
W
V
E
A
W
N
N
H
G
K
V
--
I
C
R
V
K
-
I
--
R
--
N
G
E
Q
R
G
R
V
S
M
W
H
C
P
E
L
Y
-------
M
-------
D
L----------
L
T
G
G
-
S
Q
S
V
C
P
V
--
R
I
N
P
---
T
NLVGNYGH
L
F
F
R
PNYY
G
P
A
G
--------------
S
Q
----------------
R
D
-
V
R
V
N
V
K
R
Y
-------------------
30
HHSearch
67.94
21%
17
- C3 -
3ML1
5
NAPA_CUPNH
A:
[6-802]
----------------------------------------
D
S
E
V
T
K
L
K
W
----
S
K
A
P
-
C
R
-
F
C
G
--
T
G
C
G
V
T
V
A
V
K
-
D
N
-------------------------------------------
K
V
V
A
T
Q
G
-------
D
------
P
Q
A
E
-
V
N
-------
K
G
L
-
N
C
V
K
G
Y
F
L
S
K
I
M
Y
G
-----
Q
-----
D
R
L
T
R
P
L
M
R
M
--
K
----------------------------------
N
GKY
D
-
K
N
G
D
F
A
P
V
T
W
D
Q
A
F
D
E
M
E
R
Q
F
K
R
V
L
K
E
K
G
P
T
A
V
G
M
F
G
S
-----
G
Q----
W
-
T
-
V
-
W
E
G
Y
-----
A
A
A
K
L
Y
-
K
A
G
--
F
R
S
----
N
N
I
D
PN-----
A
R
--
H
C
M
A
S
A
A
A
G
F
M
R
T
------
F
G
M
D
E
-
P
M
G
C
Y
D
D
F
E
A
-
A
D
A
F
V
L
W
G
S
N
M
A
E
-----------
M
-
H
-
P
I
--
L
-
W
--
T
R
V
-
T
---------------
D
R
R
L
S
H
-----
P
----
K
T
R
V
V
V
L
S
T
F
T
H
R
C
F
D
L
A
--------
D
I
G
--------
I
I
F
K
P
Q
T
D
L
A
M
L
N
Y
I
A
N
Y
I
I
R
N
N
------
K
V
N
K
D
F
V
N
K
H
T
---------
V
F
K
E
G
V
T
DIGYGLRPDH
P
L
Q
K
A
AKNASDPG
A
A
K
V
I
------------------------------------
T
-------------------------------------------------------------------------------------------------
F
D
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
F
V
-
S
K
Y
D
A
D
Y
V
S
K
L
S
A
V
P
K
A
K
L
D
Q
L
A
E
L
Y
------
A
D
------
P
-----
N
I
K
V
M
S
-
L
W
T
M
G
F
-
N
Q
H
T
--
R
G
T
W
A
N
N
M
V
Y
N
L
--
H
L
L
T
G
K
I
A
T
P
G
------------------
N
S
P
F
S
---
L
T
G
------------
Q
P
------------
S
A--
C
---
G
---
T
----------------
A
R----------
E
--------
V
--------
G
TFSH--------
R
----
L
P
A
D
------------------------
M
VVT
N
------
P
K
H
--------------------
R
E
E
A
E
R
----
I
------
W
--------------
K
LPPG------
T
------
I
---------------
P
DKP----------------
G
-
Y
------
D
A
V
------
L
--------------
Q
------------
N
R
-
M
-------------
L
K
D
G
-
K
L
N
A
Y
W
V
Q
V
N
N
N
M
Q
A
A
A
N
--
L
-
M
------------------------------
E
--
E
------------------------------
G
-
L
-
P
G
Y
R
N
P
A
-
N
F
I
V
V
S
D
A
Y
P
T
V
-
T
A
L
A
A
D
L
V
L
P
S
A
M
W
V
E
K
E
G
A
Y
G
N
-
A
---
E
R
--
R
T
--
Q
F
W
H
Q
L
V
D
A
P
G
E
A
R
S
D
L
W
Q
L
V
E
F
A
K
R
F
K
V
--
E
E
-------------
V
--------------
W
---------
P
P
-------
E
-------------
L
I
A
K
K
----
P
EYKG-----
K
T
L
Y
D
----------
V
----------------
L
--------------------------
Y
R
N
-
G
QVDKF
P
-----
L
-------------------------------------
K
D
VNAE
Y
HN
A
E
A
K
A
--------------
F
G
FY
L
Q
K
G
L
F
E
E
Y
A
T
F
G
RGHGHDLAP
F
D
A
Y
H
E
A
R--
G
-------------
L
--------------
R
-------
W
--------------------
P
V
--
V
N
G--------------
K
ET---
R
------
W
RYRE----
G
----------
S
D
---
P
Y
V
-------
K
A
G
T
G
F
Q
F
Y
G
N
P
D
G
-
K
-
A
-
V
I
F
A
L
P
-
Y
-
E
-
P
P
-
A
E
SP------------
D
-------
K
E
--
Y
P
Y
W
L
V
T
G
--
R
V
-
L
E
H
W
H
S
--
G
SM
T
--
R
-
R
V
P
-
E
L
Y
R
S
F
-
P
N
A
V
V
F
--
M
H
P
E
D
A
K
A
L
G
L
R
R
G
V
E
V
E
V
V
S
R
R
G
R
M
--
R
S
R
I
E
-
T
--
R
GR
D
A
P
P
R
G
L
V
F
V
P
W
F
D
------------------------------
A
S
Q
L
-
I
N
K
V
T
L
D
--
A
T
C
P
---
I
----------------
S
L
Q
T
--------------
D
F
----------------
K
K
-
C
A
V
K
I
V
K
V
-------------------
2
PsiBlast_PDB
67.91
24%
21
- C3 -
2VPX
4
?
A:
[33-674]
-----------------------------------------
Y
A
Q
E
V
K
S
V
----
Y
Q
-
I
-
C
E
-
G
C
F
--
W
R
C
G
I
V
A
H
A
V
-
G
N
-------------------------------------------
R
V
Y
K
V
E
G
-------
Y
------
E
A
N
P
-
K
S
-------
R
G
R
-
L
C
P
R
G
Q
G
A
P
Q
T
T
Y
D
-----
P
-----
D
R
L
K
R
P
L
I
R
V
EG
S
----------------------------------
Q
---
R
-
G
E
G
K
Y
R
V
A
T
W
E
E
A
L
D
H
I
A
K
K
M
L
E
I
R
E
K
Y
G
P
E
A
I
---
A
F
-----
F
-----
G
-
H
G
T
-
G
D
Y
W
F
V
D
--
F
L
P
A
A
W
-
G
-
S
--
P
N
A
----
A
K
P
S
-------
V
S
--
L
C
T
A
P
R
E
V
A
S
Q
W
V
------
F
G
-
R
P
I
G
G
H
E
P
I
D
W
E
N
-
A
R
Y
I
V
L
I
G
-
H
H
I
G
-----------
E
-
D
-
T
H
N
T
Q
-
L
--
Q
D
F
-
A
---------------
L
A
L
-
K
------
N
----
G
A
K
V
V
V
V
D
P
R
F
S
T
A
A
A
K
A
--------
H
R
W
--------
L
P
I
K
P
G
T
D
T
A
L
L
L
A
W
I
H
V
L
I
Y
E
D
------
L
Y
D
K
E
Y
V
A
K
Y
T
---------
V
----------------------------------------------------------------------
G
-------------------------------------------------------------------------------------------------
F
E
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
H
V
-
K
D
F
T
P
E
W
A
E
K
H
T
E
I
P
A
Q
V
I
R
E
V
A
R
E
M
------
A
A
------
H
-----
K
-
P
----
R
A
V
L
P
P
-
T
R
H
N
VW
Y
G
D
D
T
Y
R
V
M
A
L
L
Y
V
N
V
L
L
G
N
Y
G
R
P
G
------------------
G
F
Y
I
A
---
Q
S
P
------------
Y
L
------------
E
---
K
---
Y
---
P
LPPLP
L
E
P
A
AGGCSGP
S
-----------
G
--------
G
--------
D
------------
H
----
E
P
E
G
------------------------
F
---
K
------
P
----------------------
R
---------
A
DKGKFF
A
--------------
R
----------
S
------
T
---------------
A
-------------------
I
-
Q
------
E
--------
L
--------------
I
------------
E
P
-
M
------------
I
T
G
E
P
Y
P
I
K
G
L
F
A
Y
G
I
N
L
F
H
S
I
P
N
V
P
R
T
K
------------------------------
E
--
A
------------------------------
L
-
K
-
N
----
L
D
-
L
Y
V
A
I
-
D
V
L
P
Q
E
-
H
V
M
W
A
D
V
I
L
P
E
A
T
Y
L
E
R
Y
D
D
F
V
L
-
V
A
--
H
K
T
P
F
I
--
Q
L
R
T
P
A
H
E
P
L
F
D
T
K
P
G
W
W
I
A
R
E
L
G
L
R
L
G
L
--
E
Q
-------------
Y
--------------
F
---------
P
W
-------
K
-------------
T
--------
I
---------
E
E
Y
L
E
----------
T
----------------
R
--------------------------
L
Q
S
-------------------------------------------------------------------------------
L
G
-----
L
D
L
E
T
M
-----------------
K
G
M
---
G
-------------
T
--------------
L
----------------------------
V
Q
--
R
G
---------------
K
-----
P
------
W
--------
L
E
D
W
E
K
-----
E
G
---
R
L
P
F
G-----
T
A
S
G
K
I
E
L
Y
C
Q
R
F
K
-
E
-
A
-
G
H
Q
P
L
P
V
F
-
T
-
P
P
-
E
E
--------------
P
-------
P
E
GF
Y
R
L
L
Y
G
R
S
--
P
V
-
H
T
F
A
R
T
--------
Q
-
N
N
W
-
V
L
M
E
M
D
P
E
-
N
E
V
W
--
I
H
K
E
E
A
K
R
L
G
L
K
E
G
D
Y
V
M
L
V
N
Q
D
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
67.90
24%
20
- C3 -
2VPW
4
?
A:
[33-674]
-----------------------------------------
Y
A
Q
E
V
K
S
V
----
Y
Q
-
I
-
C
E
-
G
C
F
--
W
R
C
G
I
V
A
H
A
V
-
G
N
-------------------------------------------
R
V
Y
K
V
E
G
-------
Y
------
E
A
N
P
-
K
S
-------
R
G
R
-
L
C
P
R
G
Q
G
A
P
Q
T
T
Y
D
-----
P
-----
D
R
L
K
R
P
L
I
R
V
EG
S
----------------------------------
Q
---
R
-
G
E
G
K
Y
R
V
A
T
W
E
E
A
L
D
H
I
A
K
K
M
L
E
I
R
E
K
Y
G
P
E
A
I
---
A
F
-----
F
-----
G
-
H
G
T
-
G
D
Y
W
F
V
D
--
F
L
P
A
A
W
-
G
-
S
--
P
N
A
----
A
K
P
S
-------
V
S
--
L
C
T
A
P
R
E
V
A
S
Q
W
V
------
F
G
-
R
P
I
G
G
H
E
P
I
D
W
E
N
-
A
R
Y
I
V
L
I
G
-
H
H
I
G
-----------
E
-
D
-
T
H
N
T
Q
-
L
--
Q
D
F
-
A
---------------
L
A
L
-
K
------
N
----
G
A
K
V
V
V
V
D
P
R
F
S
T
A
A
A
K
A
--------
H
R
W
--------
L
P
I
K
P
G
T
D
T
A
L
L
L
A
W
I
H
V
L
I
Y
E
D
------
L
Y
D
K
E
Y
V
A
K
Y
T
---------
V
----------------------------------------------------------------------
G
-------------------------------------------------------------------------------------------------
F
E
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
H
V
-
K
D
F
T
P
E
W
A
E
K
H
T
E
I
P
A
Q
V
I
R
E
V
A
R
E
M
------
A
A
------
H
-----
K
-
P
----
R
A
V
L
P
P
-
T
R
H
N
VW
Y
G
D
D
T
Y
R
V
M
A
L
L
Y
V
N
V
L
L
G
N
Y
G
R
P
G
------------------
G
F
Y
I
A
---
Q
S
P
------------
Y
L
------------
E
---
K
---
Y
---
P
LPPLP
L
E
P
A
AGGCSGP
S
-----------
G
--------
G
--------
D
------------
H
----
E
P
E
G
------------------------
F
---
K
------
P
----------------------
R
---------
A
DKGKFF
A
--------------
R
----------
S
------
T
---------------
A
-------------------
I
-
Q
------
E
--------
L
--------------
I
------------
E
P
-
M
------------
I
T
G
E
P
Y
P
I
K
G
L
F
A
Y
G
I
N
L
F
H
S
I
P
N
V
P
R
T
K
------------------------------
E
--
A
------------------------------
L
-
K
-
N
----
L
D
-
L
Y
V
A
I
-
D
V
L
P
Q
E
-
H
V
M
W
A
D
V
I
L
P
E
A
T
Y
L
E
R
Y
D
D
F
V
L
-
V
A
--
H
K
T
P
F
I
--
Q
L
R
T
P
A
H
E
P
L
F
D
T
K
P
G
W
W
I
A
R
E
L
G
L
R
L
G
L
--
E
Q
-------------
Y
--------------
F
---------
P
W
-------
K
-------------
T
--------
I
---------
E
E
Y
L
E
----------
T
----------------
R
--------------------------
L
Q
S
-------------------------------------------------------------------------------
L
G
-----
L
D
L
E
T
M
-----------------
K
G
M
---
G
-------------
T
--------------
L
----------------------------
V
Q
--
R
G
---------------
K
-----
P
------
W
--------
L
E
D
W
E
K
-----
E
G
---
R
L
P
F
G-----
T
A
S
G
K
I
E
L
Y
C
Q
R
F
K
-
E
-
A
-
G
H
Q
P
L
P
V
F
-
T
-
P
P
-
E
E
--------------
P
-------
P
E
G
F
Y
R
L
L
Y
G
R
S
--
P
V
-
H
T
F
A
R
T
--------
Q
-
N
N
W
-
V
L
M
E
M
D
P
E
-
N
E
V
W
--
I
H
K
E
E
A
K
R
L
G
L
K
E
G
D
Y
V
M
L
V
N
Q
D
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
67.88
24%
22
- C3 -
2VPY
4
?
A:
[33-674]
-----------------------------------------
Y
A
Q
E
V
K
S
V
----
Y
Q
-
I
-
C
E
-
G
C
F
--
W
R
C
G
I
V
A
H
A
V
-
G
N
-------------------------------------------
R
V
Y
K
V
E
G
-------
Y
------
E
A
N
P
-
K
S
-------
R
G
R
-
L
C
P
R
G
Q
G
A
P
Q
T
T
Y
D
-----
P
-----
D
R
L
K
R
P
L
I
R
V
EG
S
----------------------------------
Q
---
R
-
G
E
G
K
Y
R
V
A
T
W
E
E
A
L
D
H
I
A
K
K
M
L
E
I
R
E
K
Y
G
P
E
A
I
---
A
F
-----
F
-----
G
-
H
G
T
-
G
D
Y
W
F
V
D
--
F
L
P
A
A
W
-
G
-
S
--
P
N
A
----
A
K
P
S
-------
V
S
--
L
C
T
A
P
R
E
V
A
S
Q
W
V
------
F
G
-
R
P
I
G
G
H
E
P
I
D
W
E
N
-
A
R
Y
I
V
L
I
G
-
H
H
I
G
-----------
E
-
D
-
T
H
N
T
Q
-
L
--
Q
D
F
-
A
---------------
L
A
L
-
K
------
N
----
G
A
K
V
V
V
V
D
P
R
F
S
T
A
A
A
K
A
--------
H
R
W
--------
L
P
I
K
P
G
T
D
T
A
L
L
L
A
W
I
H
V
L
I
Y
E
D
------
L
Y
D
K
E
Y
V
A
K
Y
T
---------
V
----------------------------------------------------------------------
G
-------------------------------------------------------------------------------------------------
F
E
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
H
V
-
K
D
F
T
P
E
W
A
E
K
H
T
E
I
P
A
Q
V
I
R
E
V
A
R
E
M
------
A
A
------
H
-----
K
-
P
----
R
A
V
L
P
P
-
T
R
H
N
VW
Y
G
D
D
T
Y
R
V
M
A
L
L
Y
V
N
V
L
L
G
N
Y
G
R
P
G
------------------
G
F
Y
I
A
---
Q
S
P
------------
Y
L
------------
E
---
K
---
Y
---
P
LPPLP
L
E
P
A
AGGCSGP
S
-----------
G
--------
G
--------
D
------------
H
----
E
P
E
G
------------------------
F
---
K
------
P
----------------------
R
---------
A
DKGKFF
A
--------------
R
----------
S
------
T
---------------
A
-------------------
I
-
Q
------
E
--------
L
--------------
I
------------
E
P
-
M
------------
I
T
G
E
P
Y
P
I
K
G
L
F
A
Y
G
I
N
L
F
H
S
I
P
N
V
P
R
T
K
------------------------------
E
--
A
------------------------------
L
-
K
-
N
----
L
D
-
L
Y
V
A
I
-
D
V
L
P
Q
E
-
H
V
M
W
A
D
V
I
L
P
E
A
T
Y
L
E
R
Y
D
D
F
V
L
-
V
A
--
H
K
T
P
F
I
--
Q
L
R
T
P
A
H
E
P
L
F
D
T
K
P
G
W
W
I
A
R
E
L
G
L
R
L
G
L
--
E
Q
-------------
Y
--------------
F
---------
P
W
-------
K
-------------
T
--------
I
---------
E
E
Y
L
E
----------
T
----------------
R
--------------------------
L
Q
S
-------------------------------------------------------------------------------
L
G
-----
L
D
L
E
T
M
-----------------
K
G
M
---
G
-------------
T
--------------
L
----------------------------
V
Q
--
R
G
---------------
K
-----
P
------
W
--------
L
E
D
W
E
K
-----
E
G
---
R
L
P
F
G-----
T
A
S
G
K
I
E
L
Y
C
Q
R
F
K
-
E
-
A
-
G
H
Q
P
L
P
V
F
-
T
-
P
P
-
E
E
--------------
P
-------
P
E
GF
Y
R
L
L
Y
G
R
S
--
P
V
-
H
T
F
A
R
T
--------
Q
-
N
N
W
-
V
L
M
E
M
D
P
E
-
N
E
V
W
--
I
H
K
E
E
A
K
R
L
G
L
K
E
G
D
Y
V
M
L
V
N
Q
D
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
67.76
23%
19
- C3 -
2NAP
5
NAPA_DESDA
A:
[4-723]
--------------------------------------------
R
P
E
K
W
----
V
K
G
V
-
C
R
-
Y
C
G
--
T
G
C
G
V
L
V
G
V
K
-
D
G
-------------------------------------------
K
A
V
A
I
Q
G
-------
N
------
P
N
N
--
H
N
-------
A
G
L
-
L
C
L
K
G
S
L
L
I
P
V
L
N
S
-----
K
-----
E
R
V
T
Q
P
L
V
R
R
--
H
----------------------------------------
K
G
G
K
L
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
N
S
V
A
W
Y
G
S
-----
G
Q----
C
-
L
-
T
-
E
E
S
Y
-----
V
A
N
K
I
F
-
K
G
G
--
F
G
T
----
N
N
V
D
GN-----
P
R
--
L
C
M
A
S
A
V
G
G
Y
V
T
S
------
F
G
K
D
E
-
P
M
G
T
Y
A
D
I
D
Q
-
A
T
C
F
F
I
I
G
S
N
T
S
E
-----------
A
-
H
-
P
V
--
L
-
F
--
R
R
I
-
A
---------------
R
R
K
-
Q
V
E
----
P
----
G
V
K
I
I
V
A
D
P
R
R
T
N
T
S
R
I
A
--------
D
M
H
--------
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
E
------
L
D
N
P
R
F
W
Q
R
Y
V
---------
N
F
M
D
AEGKPS-------------------------------------------------------------
D
-------------------------------------------------------------------------------------------------
F
E
G
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
F
L
-
E
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
A
F
------
A
E
------
S
-----
A
-
A
T
M
S
-
L
W
C
M
G
I
-
N
Q
R
V
--
Q
G
V
F
A
N
N
L
I
H
N
L
--
H
L
I
T
G
Q
I
C
R
P
G
------------------
A
T
S
F
S
---
L
T
G
------------
Q
P
------------
N
A--
C
---
G
---
G
V---------------
R
-----------
D
--------
G
--------
G
------------
A
LSHL
L
P
A
G
------------------------
R
---
A
I-----
P
N
A
K
H
------------------
R
---------
A
E
M
E
K
L
-
W
--------------
G
LPEGRIAPEP
G
------
Y
---------------
H
-------------------
T
-
V
------
A
--------
L
--------------
F
------------
E
A
-
L
--------------
G
R
G
-
D
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
L
N
K
-
V
------------------------------
H
--
K
------------------------------
A
-
M
-
S
----
H
P
E
S
F
I
V
C
I
E
A
F
P
D
A
V
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
-
G
---
E
R
--
R
Y
--
S
L
T
E
K
A
V
D
P
P
G
Q
C
R
P
T
V
N
T
L
V
E
F
A
R
R
A
G
V
--
D
P
Q------------
L
--------------
V
---------
N
F
-------
R
-------------
N
--------
A
---------
E
D
V
W
N
----------
E
----------------
W
--------------------------
R
M
V
-
S
-----
K
GT---
T
-------------------------------------
Y
D
----
F
---------------------
W
G
-----
M
T
R
E
R
L
-----------------
R
K
E
S--
G
-------------
L
--------------
I
-------
W
--------------------
P
C
--
P
S
---------------
E
-----
D
HPGTS-
L
RYV-----
R
GQDPCVPADH
P
D
RFF
F
Y
G
-------
K
P
D
G
R
A
V
I
W
M
R
P
A
K
-----------
G
A
-
A
E
E
P
-----------------
D
-------
A
E
--
Y
P
L
Y
L
T
S
M
--
R
V
-
I
D
H
W
H
T
--
A
TM
T
--
G
-
K
V
P
-
E
L
Q
K
A
N
-
P
I
A
F
V
E
--
I
N
E
E
D
A
A
R
T
G
I
K
H
G
D
S
V
I
V
E
T
R
R
D
A
M
--
E
L
P
A
R
-
V
--
S
--
D
V
C
R
P
G
L
I
A
V
P
F
F
D
P
K
------------------------------
K
L
-
V
N
K
L
F
L
D
--
A
T
D
P
---
V
----------------
S
R
E
P
--------------
E
Y
----------------
K
I
-
C
A
A
R
V
R
K
A
-------------------
48
Fugue
66.35
22%
10
- C3 -
2VPZ
4
?
A:
[30-763]
---------------------------------------
A
P
W
Y
A
Q
E
V
K
S
----
V
Y
Q
I
-
C
E
G
-
C
F
--
W
R
C
G
I
V
A
H
A
V
-
G
N
-------------------------------------------
R
V
Y
K
V
E
G
-------
Y
------
E
A
N
P
-
K
S
-------
R
G
R
-
L
C
P
R
G
Q
G
A
P
Q
T
T
Y
D
-----
P
-----
D
R
L
K
R
P
L
I
R
V
--
E
GS--------------------------------
Q
---
R
-
G
E
G
K
Y
R
V
A
T
W
E
E
A
L
D
H
I
A
K
K
M
L
E
I
R
E
K
Y
G
P
E
A
I
A
F
F
G
------
H
-----
G
-
T
-
G
-
D
Y
W
F
V
D
F
--
L
P
A
A
W
G
-
S
-
P
--
N
A
A
----
K
P
S
V
-------
S
---
L
C
T
A
P
R
E
V
A
S
Q
W
V
------
F
G
-
R
P
-
I
G
G
H
E
P
I
D
W
E
N
A
R
Y
I
V
L
I
G
H
H
I
G
E
-----------
D
-
T
-
H
N
--
T
-
Q
--
L
Q
D
F
A
---------------
L
A
L
-
K
------
N
----
G
A
K
V
V
V
V
D
P
R
F
S
T
A
A
A
K
A
--------
H
R
W
--------
L
P
I
K
P
G
T
D
T
A
L
L
L
A
W
I
H
V
L
I
Y
E
D
------
L
Y
D
K
E
Y
V
A
K
Y
T
---------
V
----------------------------------------------------------------------
G
-------------------------------------------------------------------------------------------------
F
E
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
H
V
-
K
D
F
T
P
E
W
A
E
K
H
T
E
I
P
A
Q
V
I
R
E
V
A
R
E
M
------
A
A
------
H
-----
K
-
P
R
A
V
L
P
P
T
R
H
N
-
V
W
Y
G
--
D
D
T
Y
R
V
M
A
L
L
Y
V
--
N
V
L
L
G
N
Y
G
R
P
G
------------------
G
F
Y
I
A
---
Q
S
P
------------
Y
L
------------
E
---
K
---
Y
---
P
----------------
L
-----------
P
--------
P
--------
L
------------
P
----
L
E
P
A
------------------------
A
---
G
------
G
CSGPSGGDHEPEGFKPRADKGK
F
---------
F
------
A
--------------
R
----------
S
------
T
---------------
A
-------------------
I
-
Q
------
E
--------
L
--------------
I
------------
E
P
-
M
------------
I
T
G
E
P
Y
P
I
K
G
L
F
A
Y
G
I
N
L
F
H
S
I
P
N
V
P
R
T
K
------------------------------
E
--
A
------------------------------
L
-
K
-
N
----
L
D
--
L
Y
V
A
I
D
V
L
P
Q
E
-
H
V
M
W
A
D
V
I
L
P
E
A
T
Y
L
E
R
Y
D
D
F
V
L
-
V
A
--
H
K
T
P
F
I
--
Q
L
R
T
P
A
H
E
P
L
F
D
T
K
P
G
W
W
I
A
R
E
L
G
L
R
L
G
L
--
E
Q
-------------
Y
--------------
F
---------
P
W
-------
K
-------------
T
--------
I
---------
E
E
Y
L
E
----------
T
----------------
R
--------------------------
L
Q
S
-
L
-----------
G
-------------------------------------
L
D
----
L
---------------------
E
T
-----
M
K
G
M
G
T
-----------------
L
V
Q
---
R
-------------
G
--------------
K
-------
P
--------------------
W
L
--
E
D
---------------
W
-----
E
------
K
--------
E
----------
G
R
---
L
P
F
G------
T
A
S
G
K
I
E
L
Y
C
Q
R
F
K
-
E
-
A
-
G
H
Q
P
L
P
V
F
-
T
-
P
P
-
E
E
--------------
P
-------
P
E
--
G
F
Y
R
L
L
Y
G
--
R
S
-
P
V
H
T
F
A
--
R
--
T
--
Q
-
N
N
W
-
V
L
M
E
M
D
P
E
-
N
E
V
W
--
I
H
K
E
E
A
K
R
L
G
L
K
E
G
D
Y
V
M
L
V
N
Q
D
G
V
K
--
E
G
P
V
R
-
V
K
P
T
--
A
R
I
R
K
D
C
V
Y
I
V
H
G
F
G
H
K
APLMRLA
H
-------
G
-----------
R
G
A
S
-
D
N
Y
L
Q
T
R
--
Y
K
L
D
P--
I
----------------
S
G
G
A
--------------
G
L
----------------
R
V
-
N
F
V
R
L
E
K
A
E
R
P
R
L
P
S
L
T
G
L
A
K
R
P
F
D
ER
33
HHSearch
66.14
16%
0
- C- -
1G8K
5
AIOA_ALCFA
A:
[8-807]
----------------------------------------
T
L
P
P
A
N
A
Q
R
----
T
N
M
T
-
C
H
-
F
C
I
--
V
G
C
G
Y
H
V
Y
K
W
-
P
E
L
E
E
G
G
RAPEQNALGLDFRKQLPPLA
V
T
L
T
PAM
T
N
V
V
T
E
HDG
A
R
Y
D
I
M
V
V
P
-------
D
------
K
A
C
V
-
V
N
-------
S
G
L
-
S
S
T
R
G
G
K
M
A
S
Y
M
Y
T
-----
P
TGDGK
E
R
L
S
A
P
R
L
Y
A
--
A
------------------------------------------
D
E
W
V
D
T
T
W
D
H
A
M
A
L
Y
A
G
L
I
K
K
T
L
D
K
D
G
P
Q
G
V
F
F
S
C
F
-----
D
HGGAG
G
-
G
-
F
-
E
N
T
W
-----
G
T
G
K
L
M
-
F
S
A
--
I
Q
T
----
P
M
V
R
IHNRPAY
N
S
--
E
C
H
A
T
R
E
M
----
G
------
I
G
--
E
-
L
N
N
A
Y
E
D
A
Q
L
-
A
D
V
I
W
S
I
G
N
N
P
Y
E
-----------
S
-
Q
-
T
N
--
Y
-
F
L
N
H
W
L
-
P
N
L
Q
GAT
T
S
K
K
K
E
R
F
P
N
E
N
-
F
------
P
----
Q
A
R
I
I
F
V
D
P
R
E
T
P
S
V
A
I
A
R
H
V
AGNDR
V
L
H
--------
L
A
I
E
P
G
T
D
T
A
L
F
N
G
L
F
T
Y
V
V
E
Q
G
------
W
I
D
K
P
F
I
E
A
H
T
---------
K
----------------------------------------------------------------------
G
-------------------------------------------------------------------------------------------------
F
D
D
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
T
--
N
R
L
S
L
D
E
C
S
N
I
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G
V
P
V
D
M
L
K
R
A
A
E
W
S
------
Y
K
PKASGQ
A
-----
P
-
R
T
M
H
-
A
Y
E
K
G
I
-
I
W
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N
--
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V
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S
A
L
L
D
L
--
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I
A
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H
N
V
G
R
R
G
------------------
T
G
C
V
R
---
M
G
G
------------
H
Q
------------
E
-------
G
---
Y
----------------
T
--------------------
R
--------
P
------------
P
----
Y
P
G
D
----------------------------------------------------------------------------------------------------------------------------
K
-------------------
K
-
I
------
Y
--------
I
--------------
D
------------
Q
E
-
L
--------------
I
K
G
-
K
G
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M
T
W
W
G
C
N
N
F
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T
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N
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L
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K
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ARGAT
T
E
E
M
V
D
V
I
Y
--
E
------------------------------
A
-
T
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----
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G
G
L
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T
S
I
N
L
Y
P
T
K
-
L
A
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A
A
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L
M
L
P
A
A
H
P
G
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M
N
L
T
S
M
N
-
G
---
E
R
--
R
I
--
R
L
S
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K
F
M
D
P
P
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T
A
M
A
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C
L
I
A
A
R
I
A
N
A
L
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D
--
M
Y
Q
K
D
GK
A
E
M
A
A
Q
F
E
G
--------------
F
---------
D
W
-------
K
-------------
T
--------
E
---------
E
D
A
F
N
----------
D
----------------
G
--------------------------
F
R
R
-
A
-----
G
QPGA
P
A
I
D
S
QGG-------------------------------
S
T
----
G
---------------------
H
L
-----
V
T
Y
D
R
L
-----------------
R
K
S
GNN
G
-------------
V
--------------
Q
-------
L
--------------------
P
V
--
V
S
---------------
W
DESK
G
L
V
G
T
EML
Y
--------
T
----------
E
G
---
K
F
D
-------
T
D
D
G
K
A
H
F
K
P
A
P
W
--------
N
G
L
P
A
T
-
V
-
Q
Q
--
Q
--------------
K
-------
D
K
--
Y
R
F
W
L
N
N
G
--
R
N
-
N
E
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W
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T
--
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--
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HD
Q
-
Y
N
S
-
L
M
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N
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D
D
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G
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M
L
F
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------------------------------
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---
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W
T
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---
R
----------------
D
I
I
P
--------------
Y
Y
----------------
K
G
-
T
W
G
D
I
R
K
V
-------------------
29
HHSearch
65.04
22%
21
- C3 -
1Q16
4
NARG_ECOLI
A:
[38-1228]
-----------------------------------------
Q
R
W
Q
H
D
K
I
----
V
R
S
T
H
G
V
-
N
C
T
--
G
S
C
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W
K
I
Y
V
K
-
N
G
-------------------------------------------
L
V
T
W
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T
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Q
TDYPRT
R
------
P
D
L
P
-
N
H
-------
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P
R
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G
C
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R
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A
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S
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Y
L
Y
S
-----
A
-----
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R
L
K
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M
M
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M
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HLDNPS
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T
D
Y
V
R
R
Y
T
---------
D
----------------------------------------------------------------------
M
-------------------------------------------------------------------------------------------------
P
M
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A
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------
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G
G
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Y
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------------
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---
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W
------------
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HSSQWRYETVTAEE
L
L--
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------
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----------------------
M
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------
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T
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----------
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------
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---------------
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M
N
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--------------
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R
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L
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G
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F
M
------------------------------
L
--
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V
D
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-------------
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AELAQPL
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V
K
D
W
K
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----------
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----------------
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CDLIPGKTA
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DYPA
T
Y
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-------
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--------------------
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--
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-----
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----
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----------
L
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---
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N
-------
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N
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V
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H
M
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--------------
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Y
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M
-------------------