@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu22340: (2016-07-04 )
MLNLKQIEFCLDKIGDMFPHAECELVHSNPFELVVAVALSAQCTDALVNRVTKTLFQKYKRPEDYLAVPLEELQQDIKSIGLYRNKAKNIQKLSKMIIEDYGGEVPRDRDELVKLPGVGRKTANVVVSVAFGVPAIAVDTHVERVSKRLGICRWKDSVLEVEKTLMRKVPKEDWSVTHHRLIFFGRYHCKAQSPRCAECPLLSLCREGQKRDKKGLVKR
Atome Classification :
(20 SA)
.........10........20.---...--------....30........40........50........60........70........80-.--........90........100.--------------...-------...110..-.....120.......130..--.....140......-.----150...---.------...160..----..----...170--.--...---...180.......190.......200.......210.......---------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
ML
N
L
K
Q
I
E
F
C
L
D
K
I
G
D
MFPHA
E
---
C
E
L
--------VHSNP
F
E
L
V
V
A
VALS
A
Q
C
T
D
A
L
V
N
R
V
T
K
T
L
F
Q
K
YKRPEDYLAV
P
L
E
E
L
Q
Q
D
I
K
SI--G--L
Y
R
N
K
A
K
N
I
Q
K
L
S
K
M
I
I
E
DYGG--------------EVP-------R
D
R
D
E
L
VK-LPGVGRK
T
A
N
V
V
V
S
V
AFGV
P
--
A
I
A
V
D
T
H
V
E
R
V
S
K
R
-L----GICRW
K
---
D
------
S
V
L
E
V
E
K
T
----
L
M
----
R
KVPKE--D--WSV---
T
H
H
R
L
I
F
F
G
R
Y
H
C
KAQSPRCAEC
P
L
L
S
L
C
REGQKR
D
K
KGLVKR---------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
97.05
78%
-144
- C1 -
1ORN
5
?
A:
[4-217]
M
L
T
K
Q
Q
I
R
Y
C
L
D
E
M
A
K
M
F
P
D
A
H
---
C
E
L
--------
V
H
R
N
P
F
E
L
L
I
A
V
V
L
S
A
Q
C
T
D
A
L
V
N
K
V
T
K
R
L
F
E
K
Y
R
T
P
H
D
Y
I
A
V
P
L
E
E
L
E
Q
D
I
R
S
I
--
G
--
L
Y
R
N
K
A
R
N
I
Q
K
L
C
A
M
L
I
D
K
Y
N
G
--------------
E
V
P
-------
R
D
R
D
E
L
M
K
-
L
P
G
V
G
R
K
T
A
N
V
V
V
S
V
A
F
G
V
P
--
A
I
A
V
D
T
H
V
E
R
V
S
K
R
-
L
----
G
F
C
R
W
D
---
D
------
S
V
L
E
V
E
K
T
----
L
M
----
K
I
I
P
K
E
--
E
--
W
S
I
---
T
H
H
R
M
I
F
F
G
R
Y
H
C
K
A
Q
S
P
Q
C
P
S
C
P
L
L
H
L
C
R
E
G
K
K
R
M
R
K
--------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
96.74
78%
-139
- C1 -
1ORN
5
?
A:
[8-217]
----
Q
Q
I
R
Y
C
L
D
E
M
A
K
M
F
P
D
A
H
---
C
E
L
--------
V
H
R
N
P
F
E
L
L
I
A
V
V
L
S
A
Q
C
T
D
A
L
V
N
K
V
T
K
R
L
F
E
K
Y
R
T
P
H
D
Y
I
A
V
P
L
E
E
L
E
Q
D
I
R
S
I
--
G
--
L
Y
R
N
K
A
R
N
I
Q
K
L
C
A
M
L
I
D
K
Y
N
G
--------------
E
V
P
-------
R
D
R
D
E
L
M
K
-
L
P
G
V
G
R
K
T
A
N
V
V
V
S
V
A
F
G
V
P
--
A
I
A
V
D
T
H
V
E
R
V
S
K
R
-
L
----
G
F
C
R
W
D
---
D
------
S
V
L
E
V
E
K
T
----
L
M
----
K
I
I
P
K
E
--
E
--
W
S
I
---
T
H
H
R
M
I
F
F
G
R
Y
H
C
K
A
Q
S
P
Q
C
P
S
C
P
L
L
H
L
C
R
E
G
K
K
R
M
R
K
--------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
96.45
78%
-142
- C1 -
1ORP
4
?
A:
[4-216]
M
L
T
K
Q
Q
I
R
Y
C
L
D
E
M
A
K
M
F
P
D
A
H
---
C
E
L
--------
V
H
R
N
P
F
E
L
L
I
A
V
V
L
S
A
Q
C
T
D
A
L
V
N
K
V
T
K
R
L
F
E
K
Y
R
T
P
H
D
Y
I
A
V
P
L
E
E
L
E
Q
D
I
R
S
I
--
G
--
L
Y
R
N
K
A
R
N
I
Q
K
L
C
A
M
L
I
D
K
Y
N
G
--------------
E
V
P
-------
R
D
R
D
E
L
M
K
-
L
P
G
V
G
R
K
T
A
N
V
V
V
S
V
A
F
G
V
P
--
A
I
A
V
D
T
H
V
E
R
V
S
K
R
-
L
----
G
F
C
R
W
D
---
D
------
S
V
L
E
V
E
K
T
----
L
M
----
K
I
I
P
K
E
--
E
--
W
S
I
---
T
H
H
R
M
I
F
F
G
R
Y
H
C
K
A
Q
S
P
Q
C
P
S
C
P
L
L
H
L
C
R
E
G
K
K
R
M
R
---------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
96.10
77%
-140
- C1 -
1P59
4
?
A:
[4-217]
M
L
T
K
Q
Q
I
R
Y
C
L
D
E
M
A
K
M
F
P
D
A
H
---
C
E
L
--------
V
H
R
N
P
F
E
L
L
I
A
V
V
L
S
A
Q
C
T
D
A
L
V
N
K
V
T
K
R
L
F
E
K
Y
R
T
P
H
D
Y
I
A
V
P
L
E
E
L
E
Q
D
I
R
S
I
--
G
--
L
Y
R
N
K
A
R
N
I
Q
K
L
C
A
M
L
I
D
K
Y
N
G
--------------
E
V
P
-------
R
D
R
D
E
L
M
K
-
L
P
G
V
G
R
K
T
A
N
V
V
V
S
T
A
F
G
V
P
--
A
I
A
V
D
T
H
V
E
R
V
S
K
R
-
L
----
G
F
C
R
W
D
---
D
------
S
V
L
E
V
E
K
T
----
L
M
----
K
I
I
P
K
E
--
E
--
W
S
I
---
T
H
H
R
M
I
F
F
G
R
Y
H
C
K
A
Q
S
P
Q
C
P
S
C
P
L
L
H
L
C
R
E
G
K
K
R
M
R
K
--------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
82.09
45%
-138
- C1 -
2ABK
1
END3_ECOLI
A:
[3-210]
---
K
A
K
R
L
E
I
L
T
R
L
R
E
N
N
P
H
P
T
---
T
E
L
--------
N
F
S
S
P
F
E
L
L
I
A
V
L
L
S
A
Q
A
T
D
V
S
V
N
K
A
T
A
K
L
Y
P
V
A
N
T
P
A
A
M
L
E
L
G
V
E
G
V
K
T
Y
I
K
T
I
--
G
--
L
Y
N
S
K
A
E
N
I
I
K
T
C
R
I
L
L
E
Q
H
N
G
--------------
E
V
P
-------
E
D
R
A
A
L
E
A
-
L
P
G
V
G
R
K
T
A
N
V
V
L
N
T
A
F
G
W
P
--
T
I
A
V
D
T
H
I
F
R
V
C
N
R
-
T
----
Q
F
A
P
-
G
---
K
------
N
V
E
Q
V
E
E
K
----
L
L
----
K
V
V
P
A
E
--
F
--
K
V
D
---
C
H
H
W
L
I
L
H
G
R
Y
T
C
I
A
R
K
P
R
C
G
S
C
I
I
E
D
L
C
E
Y
K
E
K
V
D
----------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
80.57
45%
-139
- C1 -
2ABK
1
END3_ECOLI
A:
[1-210]
M
N
K
A
K
R
L
E
I
-
L
T
R
L
R
E
N
N
P
H
P
T
---
T
E
L
--------
N
F
S
S
P
F
E
L
L
I
A
V
L
L
S
A
Q
A
T
D
V
S
V
N
K
A
T
A
K
L
Y
P
V
A
N
T
P
A
A
M
L
E
L
G
V
E
G
V
K
T
Y
I
K
T
I
--
G
--
L
Y
N
S
K
A
E
N
I
I
K
T
C
R
I
L
L
E
Q
H
N
G
--------------
E
V
P
-------
E
D
R
A
A
L
E
A
-
L
P
G
V
G
R
K
T
A
N
V
V
L
N
T
A
F
G
W
P
--
T
I
A
V
D
T
H
I
F
R
V
C
N
R
-
T
----
Q
F
A
P
G
K
---
N
-------
V
E
Q
V
E
E
K
----
L
L
----
K
V
V
P
A
E
--
F
--
K
V
D
---
C
H
H
W
L
I
L
H
G
R
Y
T
C
I
A
R
K
P
R
C
G
S
C
I
I
E
D
L
C
E
Y
K
E
K
V
D
----------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
56.24
27%
-10
- C1 -
4UOB
8
?
A:
[38-263]
----
V
W
F
G
E
Y
L
S
R
L
R
D
T
Y
A
P
E
L
---
P
P
P
R-------
Q
F
P
D
P
L
G
G
L
I
R
T
I
L
S
Q
Q
N
T
R
R
V
A
Q
R
Q
W
E
V
L
T
A
T
Y
P
Q
W
E
A
A
L
L
D
G
P
D
G
I
E
A
T
L
K
S
A
GG
G
--
L
S
R
M
K
A
D
Y
I
Y
G
I
L
A
H
L
Q
E
H
H
G
G
LSL
R
F
L
R
E
FPHT
P
E
G
H
E
-------
Q
A
R
Q
A
L
A
A
-
L
P
G
V
G
H
K
T
V
A
L
V
L
L
F
D
L
R
R
P
--
A
M
P
V
D
G
N
M
E
R
A
A
K
R
-
L
----
E
L
V
P
A
A
---
W
------
N
S
H
K
V
E
R
W
----
Y
A
----
E
V
M
P
A
D
--
W
E
T
R
F
A
---
L
H
I
S
G
V
R
H
G
R
D
T
C
R
S
K
H
P
L
C
P
Q
C
P
L
R
E
F
C
P
S
A
S
I
F
-----------------------------------------------------------------------------------------------------------------------------------
24
Fugue
56.18
22%
-73
- C1 -
1RRQ
4
MUTY_GEOSE
A:
[12-362]
--
P
A
R
E
F
Q
R
D
L
L
D
W
F
A
R
E
R
R
D
L
---
P
W
R
--------
K
D
R
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
--
G
--
Y
Y
-
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
--------------
K
V
P
-------
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
--
E
P
A
V
N
G
N
V
M
R
V
L
S
R
-
L
F
LVT
D
D
I
A
K
C
---
S
------
T
R
K
R
F
E
Q
I
----
V
R
----
E
I
M
A
Y
E
--
N
--
P
G
A
---
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
E
L
P
V
K
MV
K
Q
V
P
L
A
V
A
V
L
A
D
DE
G
R
V
L
I
R
K
R
D
STGLLAN
L
W
E
F
PSCETDGADG
K
E
K
L
E
Q
M
VGL
Q
V
E
L
T
E
PI
V
S
F
E
H
A
F
SHLVWQ
L
T
V
F
P
G
R
L
V
H
G
G
P
V
E
E
P
Y
R
L
A
P
EDELKA
Y
A
F
P
V
S
H
Q
R
V
W
R
E
Y
K
E
W
A
5
PsiBlast_PDB
55.95
31%
-102
- C1 -
1KEA
7
GTMR_METTF
A:
[34-218]
---------------------------------------
D
P
Y
V
I
L
I
T
E
I
L
L
R
R
T
T
A
G
H
V
K
K
I
Y
D
K
F
F
V
K
Y
K
C
F
E
D
I
L
K
T
P
K
S
E
I
A
K
D
I
K
E
I
--
G
--
L
S
N
Q
R
A
E
Q
L
K
E
L
A
R
V
V
I
N
D
Y
G
G
--------------
R
V
P
-------
R
N
R
K
A
I
L
D
-
L
P
G
V
G
K
Y
T
C
A
A
V
M
C
L
A
F
G
K
K
--
A
A
M
V
D
A
N
F
V
R
V
I
N
R
-
Y
----
F
G
G
S
Y
E
---
N
LNYNH
K
A
L
W
E
L
A
E
T
----
L
V
----
P
G
G
K
C
R
--
D
--
F
N
L
---
G
---
L
M
D
F
S
A
I
I
C
A
P
R
K
P
K
C
E
K
C
G
M
S
K
L
C
S
Y
Y
E
K
------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
55.36
29%
-18
- C1 -
4UOB
8
?
A:
[63-257]
---------------------------------------
D
P
L
G
G
L
I
R
T
I
L
S
Q
Q
N
T
R
R
V
A
Q
R
Q
W
E
V
L
T
A
T
Y
P
Q
W
E
A
A
L
L
D
G
P
D
G
I
E
A
T
L
K
S
A
--
G
GG
L
S
R
M
K
A
D
Y
I
Y
G
I
L
A
H
L
Q
E
H
H
G
G
LSL
R
F
L
R
-------
E
F
P
HT
P
E
G
H
E
Q
A
R
Q
A
L
A
A
-
L
P
G
V
G
H
K
T
V
A
L
V
L
L
F
D
L
R
R
P
--
A
M
P
V
D
G
N
M
E
R
A
A
K
R
-
L
----
E
L
V
P
A
A
---
W
------
N
S
H
K
V
E
R
W
----
Y
A
----
E
V
M
P
A
---
D
--
W
E
T
R
F
A
L
H
I
S
G
V
R
H
G
R
D
T
C
R
S
K
H
P
L
C
P
Q
C
P
L
R
E
F
C
-----------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
54.17
24%
-100
- C1 -
1WEI
5
MUTY_ECOLI
A:
[26-208]
------------------------------------
I
D
K
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
--
G
--
Y
Y
A
-
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
--------------
K
F
P
-------
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
--
F
P
I
L
D
G
N
V
K
R
V
L
A
R
-
Y
----
A
V
S
G
W
P
---
G
------
K
K
-
E
V
E
N
K
----
L
W
LSE-
Q
V
T
P
A
V
--
G
--
V
E
R
---
F
N
Q
A
M
M
D
L
G
A
M
-
C
T
R
S
K
P
K
C
-
L
C
P
L
Q
N
G
C
-----------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
53.26
24%
-85
- C1 -
1KG5
6
MUTY_ECOLI
A:
[26-208]
------------------------------------
I
D
K
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
--
G
--
Y
Y
A
-
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
--------------
K
F
P
-------
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
--
F
P
I
L
D
G
N
V
Q
R
V
L
A
R
C
Y
----
A
V
S
G
W
P
---
G
------
K
K
-
E
V
E
N
K
----
L
W
S
L
S
E
Q
V
T
P
A
V
--
G
--
V
E
R
---
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
-----------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
51.66
24%
-73
- C1 -
1WEF
1
MUTY_ECOLI
A:
[26-208]
------------------------------------
I
D
K
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
--
G
--
Y
Y
A
-
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
--------------
K
F
P
-------
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
--
F
P
I
L
D
G
N
V
K
R
V
L
A
R
C
Y
----
A
V
S
G
W
P
---
G
------
K
K
-
E
V
E
N
K
----
L
W
S
L
S
E
Q
V
T
P
A
V
--
G
--
V
E
R
---
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
-----------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
49.57
24%
-46
- C1 -
4UNF
5
?
A:
[33-245]
------
L
A
W
V
K
E
R
L
H
E
E
Y
G
D
Q
D
----
P
T
--------
P
R
R
D
P
M
H
E
L
I
S
T
I
L
S
Q
R
T
T
H
A
D
E
E
A
A
Y
Q
E
L
R
-
T
L
G
D
W
D
A
I
T
L
A
P
T
D
A
V
A
H
A
I
R
R
S
--
N
--
Y
P
E
S
K
A
P
R
I
Q
E
T
L
R
R
I
K
A
A
P
G
G
YDLDFLRDL-----
P
V
K
-------
D
A
L
K
W
L
T
D
-
L
P
G
V
G
V
K
T
A
S
L
V
L
L
F
N
Y
A
R
P
--
V
F
P
V
D
T
H
V
H
R
V
S
T
R
-
V
----
G
V
I
P
-
R
---
M
------
G
E
Q
A
A
H
R
A
----
L
L
----
A
L
L
P
P
D
P
P
Y
--
L
Y
E
---
L
H
I
N
F
L
S
H
G
R
Q
V
C
T
W
T
R
P
K
C
G
K
C
I
L
R
E
R
C
D
A
Y
A
L
Y
-----------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
48.54
28%
-30
- C1 -
1KEA
8
GTMR_METTF
A:
[6-219]
---
N
K
K
R
K
V
F
V
S
T
I
L
T
F
W
N
T
D
R
R
D
F
P
W
R
--------
H
T
R
D
P
Y
V
I
L
I
T
E
I
L
L
R
R
T
T
A
G
H
V
K
K
I
Y
D
K
F
F
V
K
Y
K
C
F
E
D
I
L
K
T
P
K
S
E
I
A
K
D
I
K
E
I
--
G
--
L
S
N
Q
R
A
E
Q
L
K
E
L
A
R
V
V
I
N
D
Y
G
G
--------------
R
V
P
-------
R
N
R
K
A
I
L
D
-
L
P
G
V
G
K
Y
T
C
A
A
V
M
C
L
A
F
G
K
K
--
A
A
M
V
D
A
N
F
V
R
V
I
N
R
-
Y
----
F
G
G
S
Y
E
NLN
Y
------
N
H
K
A
L
W
E
L
----
A
E
----
T
L
V
P
G
G
--
K
--
C
R
D
---
F
N
L
G
L
M
D
F
S
A
I
I
C
A
P
R
K
P
K
C
E
K
C
G
M
S
K
L
C
S
Y
Y
E
K
C
-----------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
48.12
24%
-35
- C1 -
3FSP
4
MUTY_GEOSE
A:
[11-224]
----
F
P
A
R
E
F
Q
R
D
L
L
D
W
F
A
R
E
R
RDL
P
W
R
--------
K
D
R
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
--
G
--
Y
Y
S
-
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
--------------
K
V
P
-------
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
--
E
P
A
V
D
G
N
V
M
R
V
L
S
R
-
L
----
F
L
V
T
D
D
---
I
AK
P
S
--
T
R
K
R
F
E
Q
I
----
V
R
----
E
I
M
A
Y
E
--
N
--
P
G
A
---
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
----------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
47.67
24%
-76
- C1 -
1MUY
4
MUTY_ECOLI
A:
[26-208]
------------------------------------
I
D
K
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
--
G
--
Y
Y
A
-
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
--------------
K
F
P
-------
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
--
F
P
I
L
D
G
N
V
K
R
V
L
A
R
C
Y
----
A
V
S
G
W
P
---
G
------
K
K
-
E
V
E
N
K
----
L
W
S
L
S
E
Q
V
T
P
A
V
--
G
--
V
E
R
---
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
-----------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
43.41
24%
-16
- C1 -
3N5N
1
MUTYH_HUMAN
X:
[13-242]
----
A
E
V
T
A
F
R
G
S
L
L
S
W
Y
D
Q
E
K
RDL
P
W
R
RRAEDEMD
L
D
R
R
A
Y
A
V
W
V
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
N
Y
Y
T
G
W
M
Q
K
W
P
T
L
Q
D
L
A
S
A
S
L
E
E
V
N
Q
L
W
A
G
L
--
G
--
Y
Y
S
-
R
G
R
R
L
Q
E
G
A
R
K
V
V
E
E
L
G
G
--------------
H
M
P
-------
R
T
A
E
T
L
Q
Q
L
L
P
G
V
G
R
Y
T
A
G
A
I
A
S
I
A
F
G
Q
A
--
T
G
V
V
D
G
N
V
A
R
V
L
C
R
-
V
----
R
A
I
G
A
D
---
P
SSTL--
V
S
Q
Q
L
W
G
L
----
A
Q
----
Q
L
V
D
P
A
--
R
--
P
G
D
---
F
N
Q
A
A
M
E
L
G
A
T
V
C
T
P
Q
R
P
L
C
S
Q
C
P
V
E
S
L
C
R
A
R
Q
R
V
E
Q
E
--------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
41.16
23%
-10
- C1 -
1KG2
6
MUTY_ECOLI
A:
[12-215]
------------
D
W
Y
D
K
Y
G
R
K
T
L--
P
W
Q
--------
I
D
K
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
--
G
--
Y
Y
-
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
--------------
K
F
P
-------
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
--
F
P
I
L
D
G
N
V
K
R
V
L
A
R
-
C
----
Y
A
V
S
G
W
---
P
------
G
K
K
E
V
E
N
K
L
W
S
L
S
E
----
Q
V
T
P
A
V
--
G
--
V
E
R
---
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
----------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
40.14
17%
-103
- C1 -
4OFA
1
A:
[63-185]
---------------------------
T
--------
L
F
H
D
P
W
K
L
L
I
A
T
I
F
L
N
R
T
S
G
K
M
A
I
P
V
L
W
K
F
L
E
K
Y
P
S
A
E
V
A
R
T
A
D
W
R
D
V
S
E
L
L
K
P
L
--
G
--
L
Y
D
L
R
A
K
T
I
V
K
F
S
D
E
Y
L
T
----------------------------
K
Q
W
K
Y
P
I
E
-
L
H
G
I
G
K
Y
G
N
D
S
Y
R
I
F
C
V
N
E
W
KQ
V
H
P
E
N
H
K
L
N
K
Y
H
D
W
-
L
----
W
E
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------