@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu22830: (2016-07-05 )
MKKVTMLGAGSWGTALALVLTDNGNEVCVWAHRADLIHQINELHENKDYLPNVKLSTSIKGTTDMKEAVSDADVIIVAVPTKAIREVLRQAVPFITKKAVFVHVSKGIEPDSLLRISEIMEIELPSDVRKDIVVLSGPSHAEEVGLRHPTTVTASSKSMRAAEEVQDLFINHNFRVYTNPDIIGVEIGGALKNIIALAAGITDGLGYGDNAKAALITRGLAEIARLGTKMGGNPLTFSGLTGVGDLIVTCTSVHSRNWRAGNLLGKGYKLEDVLEEMGMVVEGVRTTKAAYQLSKKYDVKMPITEALHQVLFNGQKVETAVESLMARGKTHEMEDLVNTFENQVK
Atome Classification :
(20 SA)
------.........10........20-------..-------...-------...30...-----.-----.-----...40........50......-..60........70........80.....-...90----.----...----.-....100..-.....--110-........120.........130.......140.......150.......160.......170.--........180.......190.......200......-----.210.......220.---......230.---..---....240.......250.......260....-...270.....----.-.280.......290.......--300.......310.......320.......330.......340...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------M
K
K
V
T
M
L
GAGSWG
T
A
L
A
L
V
L
T-------DN-------G
N
E
-------
V
C
V
WA
H
R
A
-----
D
-----
L
-----
I
H
Q
I
N
E
L
HENKDYLPN
V
K
L
S
T-SIKG
T
T
D
M
K
E
AVSDA
D
V
I
I
V
AV
P
T
K
A
I
R
E
-
V
L
R
Q
-----A----V
P
F
----
I
-TK
K
A
V
F
V
H
V-SKGI
E
--
P
D
--
S
L
L
R
I
S
E
I
M
--
E
IELPS
D
V
R
K
D
I
V
V
LSGPS
H
A
E
EVGLRHP
T
T
VTASSKS
M
R
A
A
E
E
V
Q
D
L
F
I--N--H
N
F
R
V
YTNP
D
I
I
G
V
EI
G
G
A
L
K
N
I
I
A
L
A
AGITDGLGYG-----DN
A
K
A
A
L
I
T
R
G
L
A
E
I
---
A
R
L
G
TKMGGN---PL---TFSGLTGVG
D
L
I
V
T
C
TSVHSRNWRAGNLLGK-GY
K
L
E
D
V
L
E
E
M
----
G
-
M
V
V
E
G
V
R
T
T
K
A
A
Y
QLSKKYDV--KM
P
I
T
E
A
L
H
Q
V
LFNG
Q
K
V
E
T
A
V
E
S
L
M
ARGKTH
E
M
E
D
L
V
N
T
F
E
NQVK
2
PsiBlast_PDB
83.44
37%
-112
- C1 -
3K96
1
GPDA_COXBU
A:
[32-352]
---------
I
A
I
L
G
A
G
S
W
G
T
A
L
A
L
V
L
A
-------
R
K
-------
G
Q
K
-------
V
R
L
W
S
Y
E
S
-----
D
-----
H
-----
V
D
E
M
Q
A
E
G
V
N
N
R
Y
L
P
N
Y
P
F
P
E
-
T
L
K
A
Y
C
D
L
K
A
S
L
E
G
V
T
D
I
L
I
V
V
P
S
F
A
F
H
E
-
V
I
T
R
-----
M
----
K
P
L
----
I
-
D
A
K
T
R
I
A
W
G
-
T
K
G
L
A
--
K
G
--
S
R
L
-
L
H
E
V
V
--
A
T
E
L
G
---
Q
V
P
M
A
V
I
S
G
P
S
L
A
T
E
V
A
A
N
L
P
T
A
V
S
L
A
S
N
N
S
Q
F
S
K
D
L
I
E
R
L
H
--
G
--
Q
R
F
R
V
Y
K
N
D
D
M
I
G
V
E
L
C
G
S
V
K
N
I
L
A
I
A
T
G
I
S
D
G
L
K
L
G
-----
S
N
A
R
A
A
L
I
T
R
G
L
T
E
M
---
G
R
L
V
S
V
F
G
G
K
---
Q
E
---
T
L
T
G
L
A
G
L
G
D
L
V
L
T
C
T
D
N
Q
S
R
N
R
R
F
G
L
A
L
G
E
-
G
V
D
K
K
E
A
Q
Q
A
I
----
G
-
Q
A
I
E
G
L
Y
N
T
D
Q
V
H
A
L
A
Q
K
H
A
I
--
E
M
P
L
T
F
Q
V
H
R
I
L
H
E
D
L
D
P
Q
Q
A
V
Q
E
L
L
E
R
S
-----------------
21
PsiBlast_CBE
83.22
37%
-115
- C1 -
3K96
2
GPDA_COXBU
B:
[32-351]
---------
I
A
I
L
G
A
G
S
W
G
T
A
L
A
L
V
L
A
-------
R
K
-------
G
Q
K
-------
V
R
L
W
S
Y
E
S
-----
D
-----
H
-----
V
D
E
M
Q
A
E
G
V
N
N
R
Y
L
P
N
Y
P
F
P
E
-
T
L
K
A
Y
C
D
L
K
A
S
L
E
G
V
T
D
I
L
I
V
V
P
S
F
A
F
H
E
-
V
I
T
R
-----
M
----
K
P
L
----
I
-
D
A
K
T
R
I
A
W
G
-
T
K
G
L
A
--
K
G
--
S
R
L
-
L
H
E
V
V
--
A
T
E
L
G
---
Q
V
P
M
A
V
I
S
G
P
S
L
A
T
E
V
A
A
N
L
P
T
A
V
S
L
A
S
N
N
S
Q
F
S
K
D
L
I
E
R
L
H
--
G
--
Q
R
F
R
V
Y
K
N
D
D
M
I
G
V
E
L
C
G
S
V
K
N
I
L
A
I
A
T
G
I
S
D
G
L
K
L
G
-----
S
N
A
R
A
A
L
I
T
R
G
L
T
E
M
---
G
R
L
V
S
V
F
G
G
K
---
Q
E
---
T
L
T
G
L
A
G
L
G
D
L
V
L
T
C
T
D
N
Q
S
R
N
R
R
F
G
L
A
L
G
E
-
G
V
D
K
K
E
A
Q
Q
A
I
----
G
-
Q
A
I
E
G
L
Y
N
T
D
Q
V
H
A
L
A
Q
K
H
A
I
--
E
M
P
L
T
F
Q
V
H
R
I
L
H
E
D
L
D
P
Q
Q
A
V
Q
E
L
L
E
R
------------------
54
HHSearch
80.60
38%
-85
* C1 *
3K96
1
GPDA_COXBU
A:
[29-351]
------
K
H
P
I
A
I
L
G
A
G
S
W
G
T
A
L
A
L
V
L
A
-------
R
K
-------
G
Q
K
-------
V
R
L
W
S
Y
E
S
-----
D
-----
H
-----
V
D
E
M
Q
A
E
G
V
N
N
R
Y
L
P
N
Y
P
F
P
E
-
T
L
K
A
Y
C
D
L
K
A
S
L
E
G
V
T
D
I
L
I
V
V
P
S
F
A
F
H
E
-
V
I
T
R
-----
M
----
K
P
L
----
I
-
D
A
K
T
R
I
A
W
G
-
T
K
G
L
A
--
K
G
--
S
R
-
L
L
H
E
V
V
--
A
T
E
L
G
Q
---
V
P
M
A
V
I
S
G
P
S
L
A
T
E
V
A
A
N
L
P
T
A
V
S
L
A
S
N
N
S
Q
F
S
K
D
L
I
E
R
L
H
--
G
--
Q
R
F
R
V
Y
K
N
D
D
M
I
G
V
E
L
C
G
S
V
K
N
I
L
A
I
A
T
G
I
S
D
G
L
K
L
G
-----
S
N
A
R
A
A
L
I
T
R
G
L
T
E
M
---
G
R
L
V
S
V
F
G
G
K
---
Q
E
---
T
L
T
G
L
A
G
L
G
D
L
V
L
T
C
T
D
N
Q
S
R
N
R
R
F
G
L
A
L
G
E
-
G
V
D
K
K
E
A
Q
Q
-
A
----
I
G
Q
A
I
E
G
L
Y
N
T
D
Q
V
H
A
L
A
Q
K
H
A
I
--
E
M
P
L
T
F
Q
V
H
R
I
L
H
E
D
L
D
P
Q
Q
A
V
Q
E
L
L
E
R
------------------
57
HHSearch
77.61
44%
-112
- C1 -
1Z82
7
?
A:
[14-325]
------
E
M
R
F
F
V
L
G
A
G
S
W
G
T
V
F
A
Q
M
L
H
-------
E
N
-------
G
E
E
-------
V
I
L
W
A
R
R
K
-----
E
-----
I
-----
V
D
L
I
N
V
S
H
T
S
P
-
Y
V
E
E
S
--
K
I
-
T
V
R
A
T
N
D
L
E
E
-
I
K
K
E
D
I
L
V
I
A
I
P
V
Q
Y
I
R
E
-
H
L
L
R
-----
L
----
P
V
--------
K
P
S
M
V
L
N
L
-
S
K
G
I
E
--
I
K
--
T
G
K
R
V
S
E
I
V
--
E
E
I
L
G
----
C
P
Y
A
V
L
S
G
P
S
H
A
E
E
V
A
K
K
L
P
T
A
V
T
L
A
G
E
N
S
---
K
E
L
Q
K
R
I
S
--
T
--
E
Y
F
R
V
Y
T
C
E
D
V
V
G
V
E
I
A
G
A
L
K
N
V
I
A
I
A
A
G
I
L
D
G
F
G
G
W
-----
D
N
A
K
A
A
L
E
T
R
G
I
Y
E
I
---
A
R
F
G
M
F
F
G
A
D
---
Q
K
---
T
F
M
G
L
A
G
I
G
D
L
M
V
T
C
N
S
R
Y
S
R
N
R
R
F
G
E
L
I
A
R
-
G
F
N
P
L
K
L
L
E
S
S
----
N
-
Q
V
V
E
G
A
F
T
V
K
A
V
M
K
I
A
K
E
N
K
I
--
D
M
P
I
S
E
E
V
Y
R
V
V
Y
E
G
K
P
P
L
Q
S
M
R
D
L
M
R
-------------------
5
PsiBlast_PDB
75.20
34%
-45
- C1 -
1JDJ
2
GPDA_LEIME
A:
[15-350]
------
L
N
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
-------
K
K
-------
C
R
E
-------
V
C
V
W
H
M
N
E
-----
E
-----
E
-----
V
R
L
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
-
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
-
F
F
E
K
-----
S
G
G
N
L
I
A
Y
----
A
-
K
E
K
Q
V
P
V
L
V
C
T
K
G
I
E
--
R
S
--
T
L
K
F
P
A
E
I
I
--
G
E
F
L
P
S
P
L
---
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
S
A
D
I
N
V
A
R
R
L
Q
R
I
M
S
TG
D
--
R
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
-----
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
---
R
D
L
T
A
A
L
G
G
D
---
G
S
---
A
V
F
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
V
G
K
K
L
G
K
-
G
L
P
I
E
E
I
Q
R
--------
A
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
L
K
V
--
K
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
C
G
L
Q
D
E
-------------
4
PsiBlast_PDB
75.12
34%
-45
- C1 -
1EVZ
2
GPDA_LEIME
A:
[15-350]
------
L
N
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
-------
K
K
-------
C
R
E
-------
V
C
V
W
H
M
N
E
-----
E
-----
E
-----
V
R
L
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
-
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
-
F
F
E
K
-----
S
G
G
N
L
I
A
Y
----
A
-
K
E
K
Q
V
P
V
L
V
C
T
K
G
I
E
--
R
S
--
T
L
K
F
P
A
E
I
I
--
G
E
F
L
P
S
P
L
---
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
S
A
D
I
N
V
A
R
R
L
Q
R
I
M
S
TG
D
--
R
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
-----
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
---
R
D
L
T
A
A
L
G
G
D
---
G
S
---
A
V
F
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
V
G
K
K
L
G
K
-
G
L
P
I
E
E
I
Q
R
--------
A
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
L
K
V
--
K
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
C
G
L
Q
D
E
-------------
3
PsiBlast_PDB
75.10
34%
-46
- C1 -
1EVY
1
GPDA_LEIME
A:
[15-350]
------
L
N
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
-------
K
K
-------
C
R
E
-------
V
C
V
W
H
M
N
E
-----
E
-----
E
-----
V
R
L
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
-
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
-
F
F
E
K
-----
S
G
G
N
L
I
A
Y
----
A
-
K
E
K
Q
V
P
V
L
V
C
T
K
G
I
E
--
R
S
--
T
L
K
F
P
A
E
I
I
--
G
E
F
L
P
S
P
L
---
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
S
A
D
I
N
V
A
R
R
L
Q
R
I
M
S
TG
D
--
R
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
-----
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
---
R
D
L
T
A
A
L
G
G
D
---
G
S
---
A
V
F
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
V
G
K
K
L
G
K
-
G
L
P
I
E
E
I
Q
R
--------
A
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
L
K
V
--
K
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
C
G
L
Q
D
E
-------------
7
PsiBlast_PDB
75.03
34%
-48
- C1 -
1M67
2
GPDA_LEIME
A:
[15-350]
------
L
N
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
-------
K
K
-------
C
R
E
-------
V
C
V
W
H
M
N
E
-----
E
-----
E
-----
V
R
L
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
-
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
-
F
F
E
K
-----
S
G
G
N
L
I
A
Y
----
A
-
K
E
K
Q
V
P
V
L
V
C
T
K
G
I
E
--
R
S
--
T
L
K
F
P
A
E
I
I
--
G
E
F
L
P
S
P
L
---
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
S
A
D
I
N
V
A
R
R
L
Q
R
I
M
S
TG
D
--
R
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
-----
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
---
R
D
L
T
A
A
L
G
G
D
---
G
S
---
A
V
F
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
V
G
K
K
L
G
K
-
G
L
P
I
E
E
I
Q
R
--------
A
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
L
K
V
--
K
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
C
G
L
Q
D
E
-------------
22
PsiBlast_CBE
74.87
34%
-44
- C1 -
1N1E
1
GPDA_LEIME
B:
[15-350]
------
L
N
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
-------
K
K
-------
C
R
E
-------
V
C
V
W
H
M
N
E
-----
E
-----
E
-----
V
R
L
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
-
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
-
F
F
E
K
-----
S
GGNL
I
A
Y
----
A
-
K
E
K
Q
V
P
V
L
V
C
T
K
G
I
E
--
R
S
--
T
L
K
F
P
A
E
I
I
--
G
E
F
L
P
S
P
L
---
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
S
A
D
I
N
V
A
R
R
L
Q
R
I
M
S
TG
D
--
R
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
-----
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
---
R
D
L
T
A
A
L
G
G
D
---
G
S
---
A
V
F
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
V
G
K
K
L
G
K
-
G
L
P
I
E
E
I
Q
R
T
S
----
K
-
A
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
L
K
V
--
K
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
C
G
L
Q
D
E
-------------
9
PsiBlast_PDB
74.79
34%
-45
- C1 -
1N1G
3
GPDA_LEIME
A:
[15-350]
------
L
N
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
-------
K
K
-------
C
R
E
-------
V
C
V
W
H
M
N
E
-----
E
-----
E
-----
V
R
L
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
-
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
-
F
F
E
K
-----
S
G
G
N
L
I
A
Y
----
A
-
K
E
K
Q
V
P
V
L
V
C
T
K
G
I
E
--
R
S
--
T
L
K
F
P
A
E
I
I
--
G
E
F
L
P
S
P
L
---
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
S
A
D
I
N
V
A
R
R
L
Q
R
I
M
S
TG
D
--
R
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
-----
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
---
R
D
L
T
A
A
L
G
G
D
---
G
S
---
A
V
F
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
V
G
K
K
L
G
K
-
G
L
P
I
E
E
I
Q
R
--------
A
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
L
K
V
--
K
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
C
G
L
Q
D
E
-------------
6
PsiBlast_PDB
74.58
34%
-44
- C1 -
1M66
2
GPDA_LEIME
A:
[15-350]
------
L
N
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
-------
K
K
-------
C
R
E
-------
V
C
V
W
H
M
N
E
-----
E
-----
E
-----
V
R
L
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
-
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
-
F
F
E
K
-----
S
G
G
N
L
I
A
Y
----
A
-
K
E
K
Q
V
P
V
L
V
C
T
K
G
I
E
--
R
S
--
T
L
K
F
P
A
E
I
I
--
G
E
F
L
P
S
P
L
---
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
S
A
D
I
N
V
A
R
R
L
Q
R
I
M
S
TG
D
--
R
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
-----
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
---
R
D
L
T
A
A
L
G
G
D
---
G
S
---
A
V
F
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
V
G
K
K
L
G
K
-
G
L
P
I
E
E
I
Q
R
--------
A
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
L
K
V
--
K
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
C
G
L
Q
D
E
-------------
8
PsiBlast_PDB
74.48
34%
-45
- C1 -
1N1E
1
GPDA_LEIME
A:
[15-350]
------
L
N
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
-------
K
K
-------
C
R
E
-------
V
C
V
W
H
M
N
E
-----
E
-----
E
-----
V
R
L
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
-
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
-
F
F
E
K
-----
S
G
G
N
L
I
A
Y
----
A
-
K
E
K
Q
V
P
V
L
V
C
T
K
G
I
E
--
R
S
--
T
L
K
F
P
A
E
I
I
--
G
E
F
L
P
S
P
L
---
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
S
A
D
I
N
V
A
R
R
L
Q
R
I
M
S
TG
D
--
R
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
-----
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
---
R
D
L
T
A
A
L
G
G
D
---
G
S
---
A
V
F
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
V
G
K
K
L
G
K
-
G
L
P
I
E
E
I
Q
R
T
S
----
K
-
A
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
L
K
V
--
K
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
C
G
L
Q
D
E
-------------
55
HHSearch
74.19
35%
-48
- C1 -
1EVY
1
GPDA_LEIME
A:
[15-344]
------
L
N
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
-------
K
K
-------
C
R
E
-------
V
C
V
W
H
M
N
E
-----
E
-----
E
-----
V
R
L
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
-
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
-
F
F
E
K
-----
S
----
G
G
N
L
I
A
Y
A
K
E
K
Q
V
P
V
L
V
C
-
T
K
G
I
E
--
R
S
--
T
L
K
F
P
A
E
I
I
--
G
E
F
L
P
S
---
P
L
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
S
A
D
I
N
V
A
R
R
L
Q
R
I
M
S
--
T
GD
R
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
-----
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
---
R
D
L
T
A
A
L
G
G
D
---
G
S
---
A
V
F
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
V
G
K
K
L
G
K
-
G
L
P
I
E
E
I
Q
R
--------
A
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
L
K
V
--
K
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
-------------------
44
Fugue
72.26
34%
-6
- C1 -
1EVY
1
GPDA_LEIME
A:
[9-357]
KD
E
L
L
Y
L
N
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
-------
K
K
-------
C
R
E
-------
V
C
V
W
H
M
N
E
-----
E
-----
E
-----
V
R
L
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
-
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
-
F
F
E
K
SG
G
N
L
I
----
A
Y
A
----
K
-
E
K
Q
V
P
V
L
V
C
-
T
K
G
I
E
--
R
S
--
T
L
K
F
P
A
E
I
I
--
G
E
F
L
P
S
P
L
---
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
S
A
D
I
N
V
A
R
R
L
Q
R
I
M
S
TG
D
--
R
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
-----
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
---
R
D
L
T
A
A
L
G
G
D
---
G
S
---
A
V
F
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
V
G
K
K
L
G
K
-
G
L
P
I
E
E
I
Q
-------
R
-
A
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
L
K
V
--
K
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
C
G
L
Q
D
E
G
L
P
P
L
F
K
------
56
HHSearch
69.49
35%
3
- C1 -
1TXG
5
GPDA_ARCFU
A:
[1-333]
-------
M
I
V
S
I
L
G
A
G
A
M
G
S
A
L
S
V
P
L
V
-------
D
N
-------
G
N
E
-------
V
R
I
W
G
T
E
F
D
T
---
E
-----
I
-----
L
K
S
I
S
A
G
R
E
H
P
R
L
--
G
V
K
L
N
G
V
E
I
F
W
P
E
Q
L
E
K
C
L
E
N
A
E
V
V
L
L
G
V
S
T
D
G
V
L
P
-
V
M
S
R
-----
I
----
L
P
Y
----
L
-
K
-
D
Q
Y
I
V
L
I
-
S
K
G
L
I
--
D
F
DN
S
V
L
T
V
P
E
A
V
--
W
R
L
K
H
D
-
L
R
E
R
T
V
A
I
T
G
P
A
I
A
R
E
V
A
K
R
M
P
T
T
V
V
F
S
S
P
S
E
S
S
A
N
K
M
K
E
I
F
E
--
T
--
E
Y
F
G
V
E
V
T
T
D
I
I
G
T
E
I
T
S
A
L
K
N
V
Y
S
I
A
I
A
W
I
R
G
Y
E
S
R
K
NVEM
S
N
A
K
G
V
I
A
T
R
A
I
N
E
M
---
A
E
L
I
E
I
L
G
G
D
---
R
E
---
T
A
F
G
L
S
G
F
G
D
L
I
A
T
F
R
G
--
G
R
N
G
M
L
G
E
L
L
G
K
-
G
L
S
I
D
E
A
M
E
E
L
E
R
R
G
V
-
G
V
V
E
G
Y
K
T
A
E
K
A
Y
R
L
S
S
K
I
N
A
--
D
T
K
L
L
D
S
I
Y
R
V
L
Y
E
G
L
K
V
E
E
V
L
F
E
L
A
T
-------------------
1
PsiBlast_PDB
68.71
42%
-39
- C1 -
1Z82
7
?
A:
[16-325]
--------
R
F
F
V
L
G
A
G
S
W
G
T
V
F
A
Q
M
L
H
-------
E
N
-------
G
E
E
-------
V
I
L
W
A
R
R
K
-----
E
-----
I
-----
V
D
L
I
N
V
S
H
-
T
S
P
Y
V
E
E
S
K
I
T
---
V
R
A
T
N
D
L
E
E
-
I
K
K
E
D
I
L
V
I
A
I
P
V
Q
Y
I
R
E
H
L
L
R
L
-----
P
----
V
---------
K
P
S
M
V
L
N
L
-
S
K
G
I
E
--
I
K
--
T
G
K
R
V
S
E
I
V
--
E
E
I
L
G
C
P
Y
----
A
V
L
S
G
P
S
H
A
E
E
V
A
K
K
L
P
T
A
V
T
L
A
G
E
N
---
S
K
E
L
Q
K
R
I
S
--
T
--
E
Y
F
R
V
Y
T
C
E
D
V
V
G
V
E
I
A
G
A
L
K
N
V
I
A
I
A
A
G
I
L
D
G
F
G
G
W
-----
D
N
A
K
A
A
L
E
T
R
G
I
Y
E
I
---
A
R
F
G
M
F
F
G
A
D
---
Q
K
---
T
F
M
G
L
A
G
I
G
D
L
M
V
T
C
N
S
R
Y
S
R
N
R
R
F
G
E
L
I
A
R
-
G
F
N
P
L
K
L
L
E
S
S
----
N
-
Q
V
V
E
G
A
F
T
V
K
A
V
M
K
I
A
K
E
N
K
I
--
D
M
P
I
S
E
E
V
Y
R
V
V
Y
E
G
K
P
P
L
Q
S
M
R
D
L
M
R
-------------------
53
HHSearch
68.40
32%
-4
- C1 -
1X0V
7
GPDA_HUMAN
A:
[8-353]
------
S
K
K
V
C
I
V
G
S
G
N
W
G
S
A
I
A
K
I
V
G
G
N
A
A
Q
L
A
Q
F
-------
D
P
R
-------
V
T
M
W
V
F
E
E
-----
D
-----
I
GGKK
L
T
E
I
I
N
T
Q
H
E
N
V
K
Y
L
P
G
H
K
L
P
P
-
N
V
V
A
V
P
D
V
V
Q
A
A
E
D
A
D
I
L
I
F
V
V
P
H
Q
F
I
G
K
-
I
C
D
Q
-----
L
----
K
G
H
----
L
-
K
A
N
A
T
G
I
S
L
-
I
K
G
V
D
--
E
G
PN
G
L
K
L
I
S
E
V
I
--
G
E
R
L
G
----
I
P
M
S
V
L
M
G
A
N
I
A
S
E
V
A
D
E
K
F
C
E
T
T
I
G
C
K
D
P
A
Q
G
Q
L
L
K
E
L
M
Q
--
T
--
P
N
F
R
I
T
V
V
Q
E
V
D
T
V
E
I
C
G
A
L
K
N
V
V
A
V
G
A
G
F
C
D
G
L
G
F
G
-----
D
N
T
K
A
A
V
I
R
L
G
L
M
E
M
---
I
A
F
A
K
L
F
C
S
G
PVS
S
A
---
T
F
L
E
S
C
G
V
A
D
L
I
T
T
C
Y
G
--
G
R
N
R
K
V
A
E
A
F
A
R
T
G
K
S
I
E
Q
L
E
K
E
L
LN--
G
-
Q
K
L
Q
G
P
E
T
A
R
E
L
Y
S
I
L
Q
H
K
G
L
VD
K
F
P
L
F
M
A
V
Y
K
V
C
Y
E
G
Q
P
V
G
E
F
I
H
C
L
Q
N
H
P
E
H
---------------
24
PsiBlast_CBE
68.28
32%
-5
- C1 -
2PLA
3
GPD1L_HUMAN
B:
[7-346]
--------
K
V
C
I
V
G
S
G
N
W
G
S
A
V
A
K
I
I
G
-------
N
N
VKKLQKF
A
S
T
-------
V
K
M
W
V
F
E
E
TVNGR
K
-----
L
-----
T
D
I
I
N
N
D
H
E
N
V
K
Y
L
P
G
H
K
L
P
E
-
N
V
V
A
M
S
N
L
S
E
A
V
Q
D
A
D
L
L
V
F
V
I
P
H
Q
F
I
H
R
-
I
C
D
E
-----
I
----
T
G
R
----
V
-
P
K
K
A
L
G
I
T
L
-
I
K
G
I
D
EG
P
E
--
G
L
K
L
I
S
D
I
I
--
R
----
E
K
M
G
I
D
I
S
V
L
M
G
A
N
I
A
N
E
V
A
A
E
K
F
C
E
T
T
I
G
S
K
V
M
E
N
G
L
L
F
K
E
L
L
Q
--
T
--
P
N
F
R
I
T
V
V
D
D
A
D
T
V
E
L
C
G
A
L
K
N
I
V
A
V
G
A
G
F
C
D
G
L
R
C
G
-----
D
N
T
K
A
A
V
I
R
L
G
L
M
E
M
IAF
A
R
I
F
C
K
G
Q
V
S
---
T
A
---
T
F
L
E
S
C
G
V
A
D
L
I
T
T
C
Y
G
--
G
R
N
R
R
V
A
E
A
F
A
R
T
G
K
T
I
E
E
L
E
K
E
M
LN--
G
-
Q
K
L
Q
G
P
Q
T
S
A
E
V
Y
R
I
L
K
Q
K
G
L
LD
K
F
P
L
F
T
A
V
Y
Q
I
C
Y
E
S
R
P
V
Q
E
M
L
S
C
L
Q
S
-------------------
14
PsiBlast_PDB
67.44
30%
-3
- C1 -
1WPQ
6
GPDA_HUMAN
A:
[4-342]
-------
K
K
V
C
I
V
G
S
G
N
W
G
S
A
I
A
K
I
V
G
-------
G
N
-------
A
A
Q
LAQFDP
R
V
T
M
W
V
F
E
E
-----
D
IGGKK
L
-----
T
E
I
I
N
T
Q
H
E
N
V
K
Y
L
P
G
H
K
L
P
P
-
N
V
V
A
V
P
D
V
V
Q
A
A
E
D
A
D
I
L
I
F
V
V
P
H
Q
F
I
G
K
-
I
C
D
Q
-----
L
----
K
G
H
----
L
-
K
A
N
P
T
G
I
S
L
-
I
K
G
V
D
E
G
P
N
--
G
L
K
L
I
S
E
V
I
G
E
R
L
G
I
P
------
M
S
V
L
M
G
A
N
I
A
S
E
V
A
D
E
K
F
C
E
T
T
I
G
C
K
D
P
A
Q
G
Q
L
L
K
E
L
M
Q
--
T
--
P
N
F
R
I
T
V
V
Q
E
V
D
T
V
E
I
C
G
A
L
K
N
V
V
A
V
G
A
G
F
C
D
G
L
G
F
G
-----
D
N
T
K
A
A
V
I
R
L
G
L
M
E
M
---
I
A
F
A
K
L
F
C
S
G
---
P
V
S
S
A
T
F
L
E
S
C
G
V
A
D
L
I
T
T
C
Y
G
--
G
R
N
R
K
V
A
E
A
F
A
R
T
G
K
S
I
E
Q
L
E
K
E
L
LN--
G
-
Q
K
L
Q
G
P
E
T
A
R
E
L
Y
S
I
L
Q
H
K
G
L
VD
K
F
P
L
F
M
A
V
Y
K
V
C
Y
E
G
Q
P
V
G
E
F
I
H
C
L
---------------------
12
PsiBlast_PDB
67.36
30%
-6
- C1 -
1X0X
6
GPDA_HUMAN
A:
[9-347]
-------
K
K
V
C
I
V
G
S
G
N
W
G
S
A
I
A
K
I
V
G
-------
G
N
-------
A
A
Q
LAQFDPR
V
T
M
W
V
F
E
E
-----
D
I
GGKK
L
-----
T
E
I
I
N
T
Q
H
E
N
V
K
Y
L
P
G
H
K
L
P
P
-
N
V
V
A
V
P
D
V
V
Q
A
A
E
D
A
D
I
L
I
F
V
V
P
H
Q
F
I
G
K
-
I
C
D
Q
-----
L
----
K
G
H
----
L
-
K
A
N
A
T
G
I
S
L
-
I
K
G
V
D
E
G
P
N
--
G
L
K
L
I
S
E
V
I
G
E
R
L
G
I
P
------
M
S
V
L
M
G
A
N
I
A
S
E
V
A
D
E
K
F
C
E
T
T
I
G
C
K
D
P
A
Q
G
Q
L
L
K
E
L
M
Q
--
T
--
P
N
F
R
I
T
V
V
Q
E
V
D
T
V
E
I
C
G
A
L
K
N
V
V
A
V
G
A
G
F
C
D
G
L
G
F
G
-----
D
N
T
K
A
A
V
I
R
L
G
L
M
E
M
---
I
A
F
A
K
L
F
C
S
G
---
P
V
S
S
A
T
F
L
E
S
C
G
V
A
D
L
I
T
T
C
Y
G
--
G
R
N
R
K
V
A
E
A
F
A
R
T
G
K
S
I
E
Q
L
E
K
E
L
LN--
G
-
Q
K
L
Q
G
P
E
T
A
R
E
L
Y
S
I
L
Q
H
K
G
L
VD
K
F
P
L
F
M
A
V
Y
K
V
C
Y
E
G
Q
P
V
G
E
F
I
H
C
L
---------------------