@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu25500: (2016-07-10 )
MKSAYIHIPFCEHICHYCDFNKYFIQSQPVDEYLNALEQEMINTIAKTGQPDLKTIFIGGGTPTSLSEEQLKKLMDMINRVLKPSSDLSEFAVEANPDDLSAEKLKILKEAGVNRLSFGVQTFEDDLLEKIGRVHKQKDVFTSFERAREIGFENISLDLMFGLPGQTLKHLEHSINTALSLDAEHYSVYSLIVEPKTVFYNLMQKGRLHLPPQEQEAEMYEIVMSKMEAHGIHQYEISNFAKAGMESKHNLTYWSNEQYFGFGAGAHGYIGGTRTVNVGPVKHYIDLIAEKGFPYRDTHEVTTEEQIEEEMFLGLRKTAGVSKKRFAEKYGRSLDGLFPSVLKDLAEKGLIHNSESAVYLTHQGKLLGNEVFGAFLGEL
Atome Classification :
(20 SA)
------------------------------------------.........-10.........20..--.--..-----.-.-.30........40........50-........60.-...-.-..--.70..--......80........90........100.......110--.......120.......130.---.---......140.....-------..150.....--..160.......170...---....------180-........190.......200.......210.......220.......230.......240---....----------.------------...250...--....--------260...-....270....--...--280.......290.......300.......310.......320.......330.......---340--..---......350.......360.......370.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------------------MKS
A
Y
I
HI
P
-
F
-
C
E
H
I
C
H
Y
CD
F
N
K
Y
--F--IQ-----S-Q-
P
V
D
E
Y
L
N
A
L
E
Q
E
M
I
N
T
I
A
KTGQP-D
L
K
T
I
F
IGGGT-PTS-L-
S
E
--
E
Q
L
K
K
--
L
M
D
M
I
N
R
VLKPS
S
D
L
S
E
F
AVEANPDDL
S
A
E
K
L
K
I
L
K
E
AG--V
N
R
L
S
F
G
V
Q
T
F
E
D
D
L
L
E
K
I
-
G
---
R
---
V
H
K
Q
K
D
V
F
T
S
F
E
R
A
-------
R
E
IGFENI
S
L
--
D
L
M
FGLP
G
Q
T
L
K
H
L
E
H
S
I---NT
A
L
------
S
L--DAE
H
Y
S
V
Y
S
L
I
VE
P
K
T
V
F
Y
N
L
M
QKGRLHLPP
Q
E
Q
E
A
E
M
Y
E
I
V
M
S
K
M
E
AHGI
H
Q
Y
E
I
S
N
F
A
----
K
AGM----------E------------SKHNL
T
Y
WS--N
E
Q
Y
--------
F
G
FGAG-AHGYIGG
T
R
T
V
--N
V
G
--
P
V
K
H
Y
I
D
L
I
A
EKGFPYRDTHEV
T
T
E
E
Q
I
E
E
E
M
F
L
G
L
R
K
TAGV
S
K
K
R
F
A
E
K
YG
R
S
L
D
G
L
F
P
---
S
V
---
L
K
---
D
L
A
EKGLIHNSE
S
A
V
Y
L
THQG
K
L
L
G
N
E
V
F
G
A
F
L
GEL
1
PsiBlast_PDB
84.39
25%
6
- C2 -
1OLT
3
HEMN_ECOLI
A:
[54-440]
--------------------------------------------
S
L
Y
V
H
I
P
-
F
-
C
H
K
L
C
Y
F
C
G
C
N
K
I
--
V
--
T
R
-----
Q
-
Q
H
K
A
D
Q
Y
L
D
A
L
E
Q
E
I
V
H
R
A
P
L
F
A
G
R
-
H
V
S
Q
L
H
W
G
G
G
T
-
P
T
Y
-
L
-
N
K
--
A
Q
I
S
R
--
L
M
K
L
L
R
E
N
F
Q
F
N
A
D
-
A
E
I
S
I
E
V
D
P
R
E
I
E
L
D
V
L
D
H
L
R
A
E
G
--
F
N
R
L
S
M
G
V
Q
D
F
N
K
E
V
Q
R
L
V
-
N
---
R
---
E
Q
D
E
E
F
I
F
A
L
L
N
H
A
-------
R
E
I
G
F
T
S
T
N
I
--
D
L
I
Y
G
L
P
K
Q
T
P
E
S
F
A
F
T
L
---
K
R
V
A
------
E
L
--
N
P
D
R
L
S
V
F
N
Y
A
H
L
P
-
T
I
F
A
A
Q
R
K
I
K
D
A
D
L
P
S
P
Q
Q
K
L
D
I
L
Q
E
T
I
A
F
L
T
Q
S
G
Y
Q
F
I
G
M
D
H
F
A
----
R
P
D
D
----------
E
L
A
V
A
Q
R
E
G
V
L
H
R
N
F
Q
G
Y
T
T
Q
G
--
D
T
D
L
--------
L
G
M
G
V
S
-
A
I
S
M
I
G
D
C
Y
A
Q
--
N
Q
K
--
E
L
K
Q
Y
Y
Q
Q
V
D
E
Q
G
N
A
L
W
R
G
I
A
L
T
R
D
D
C
I
R
R
D
V
I
K
S
L
I
C
N
F
R
L
D
Y
S
P
I
E
Q
Q
W
D
L
L
F
A
D
Y
F
A
---
E
D
---
L
K
L
L
A
P
L
A
K
D
G
L
V
D
V
D
E
K
G
I
Q
V
T
A
K
G
R
L
L
I
R
N
I
C
M
C
F
----
30
HHSearch
83.62
25%
6
- C2 -
1OLT
3
HEMN_ECOLI
A:
[53-443]
-------------------------------------------
L
S
L
Y
V
H
I
P
-
F
-
C
H
K
L
C
Y
F
C
G
C
N
K
I
--
V
--
T
R
Q----
Q
-
H
-
K
A
D
Q
Y
L
D
A
L
E
Q
E
I
V
H
R
A
P
L
F
A
G
R
-
H
V
S
Q
L
H
W
G
G
G
T
-
P
T
Y
-
L
-
N
K
--
A
Q
I
S
R
--
L
M
K
L
L
R
E
N
F
Q
F
-
N
A
D
A
E
I
S
I
E
V
D
P
R
E
I
E
L
D
V
L
D
H
L
R
A
E
G
--
F
N
R
L
S
M
G
V
Q
D
F
N
K
E
V
Q
R
L
V
-
N
---
R
---
E
Q
D
E
E
F
I
F
A
L
L
N
H
A
-------
R
E
I
G
F
T
S
T
N
I
--
D
L
I
Y
G
L
P
K
Q
T
P
E
S
F
A
F
T
L
---
K
R
V
A
------
E
L
--
N
P
D
R
L
S
V
F
N
Y
A
H
L
P
T
I
F
A
A
Q
R
K
I
-
K
D
A
D
L
P
S
P
Q
Q
K
L
D
I
L
Q
E
T
I
A
F
L
T
Q
S
G
Y
Q
F
I
G
M
D
H
F
A
----
R
P
D
D
E
L
A
V
A
Q
R
E
G
V
L
------------
H
R
N
F
Q
G
Y
T
T
QG
D
T
D
L
--------
L
G
M
G
V
S
-
A
I
S
M
I
G
D
C
Y
A
Q
--
N
Q
K
--
E
L
K
Q
Y
Y
Q
Q
V
D
E
Q
G
N
A
L
W
R
G
I
A
L
T
R
D
D
C
I
R
R
D
V
I
K
S
L
I
C
N
F
R
L
D
Y
S
P
I
E
Q
Q
W
D
L
L
F
A
D
Y
F
A
E
D
L
K
L
---
L
A
---
P
L
A
K
D
G
L
V
D
V
D
E
K
G
I
Q
V
T
A
K
G
R
L
L
I
R
N
I
C
M
C
F
D
T
Y
-
21
Fugue
82.08
25%
40
- C2 -
1OLT
3
HEMN_ECOLI
A:
[4-444]
-QQ
I
D
W
D
LALIKYYTSYPTALEFSEDFG
E
Q
A
F
L
Q
A
V
A
RYPE
R
P
L
S
L
Y
V
H
I
P
-
F
-
C
H
K
L
C
Y
F
C
G
C
N
K
I
--
V
--
T
R
-----
Q
Q
H
-
K
A
D
Q
Y
L
D
A
L
E
Q
E
I
V
H
R
A
P
L
F
A
G
R
-
H
V
S
Q
L
H
W
G
G
G
T
-
P
T
Y
-
L
-
N
K
--
A
Q
I
S
R
--
L
M
K
L
L
R
E
N
F
-
Q
F
N
A
D
A
E
I
S
I
E
V
D
P
R
E
I
E
L
D
V
L
D
H
L
R
A
E
G
--
F
N
R
L
S
M
G
V
Q
D
F
N
K
E
V
Q
R
L
V
-
N
---
R
---
E
Q
D
E
E
F
I
F
A
L
L
N
H
A
-------
R
E
I
G
F
T
S
T
N
I
--
D
L
I
Y
G
L
P
K
Q
T
P
E
S
F
A
F
T
L
---
K
R
V
A
------
E
L
--
N
P
D
R
L
S
V
F
N
Y
A
H
L
P
T
I
-
F
A
A
Q
R
K
I
K
D
A
D
L
P
S
P
Q
Q
K
L
D
I
L
Q
E
T
I
A
F
L
T
Q
S
G
Y
Q
F
I
G
M
D
H
F
A
R
PDD
E
L
A
V
----------
A
------------
Q
R
E
G
V
L
H
R
N
--
F
Q
G
Y
TTQGD
T
D
L
L
G
M
G
V
S
-
A
I
S
M
I
G
D
C
Y
A
Q
--
N
Q
K
--
E
L
K
Q
Y
Y
Q
Q
V
D
E
Q
G
N
A
L
W
R
G
I
A
L
T
R
D
D
C
I
R
R
D
V
I
K
S
L
I
C
N
F
R
L
D
Y
S
P
I
E
Q
Q
W
D
L
L
F
A
D
Y
F
A
---
E
D
L
K
L
L
A
---
P
L
A
K
D
G
L
V
D
V
D
E
K
G
I
Q
V
T
A
K
G
R
L
L
I
R
N
I
C
M
C
F
D
T
Y
L
22
Fugue
48.75
15%
41
- C2 -
1R30
5
BIOB_ECOLI
A:
[27-338]
---R
P
R
W
T
L
S
Q
V
T
E
L
F
E
KP
L
L
D
L
L
F
E
A
Q
Q
V
H
R
Q
H
FDPR
Q
V
Q
V
S
T
L
L
S
I
K
T
G
-
A
-
C
P
E
D
C
K
Y
C
P
Q
S
S
R
------
Y
-----
K
-
T
-
G
L
E
A
E
R
L
M
E
V
E
Q
V
L
E
S
A
R
K
A
K
A
A
-
G
S
T
R
F
C
M
G
A
A
--
W
K
N
-
P
-
H
E
--
R
D
M
P
Y
--
L
E
Q
M
V
Q
G
V
K
A
-----
M
G
L
E
A
C
M
T
L
G
T
L
S
E
S
Q
A
Q
R
L
A
N
A
G
--
L
D
Y
Y
N
H
N
L
D
T
-
S
P
E
F
Y
G
N
I
-
I
---
T
---
T
R
T
Y
Q
E
R
L
D
T
L
E
K
V
-------
R
D
A
G
I
-
K
V
C
S
--
G
G
I
V
G
L
-
G
E
T
V
K
D
R
A
G
L
L
---
L
Q
L
A
------
N
L
--
P
T
P
P
E
S
V
P
I
N
M
L
V
K
V
-------
K
G
T
P
L
A
D
N
D
D
V
D
A
F
D
F
I
R
T
I
A
V
A
R
I
M
M
P
T
S
Y
V
R
L
S
--------
A
G
R
----------
E
------------
Q
-----
M
N
E
--
Q
T
Q
A
--------
M
C
F
M
A
G
-
A
N
S
I
F
Y
G
C
K
L
L
--
T
T
P
NP
E
E
D
K
D
L
Q
L
F
R
K
L
G
L
N
P
Q
Q
T
------------------------------------------------------------------------------------------
2
PsiBlast_PDB
47.08
21%
29
- C2 -
4JC0
1
RIMO_THEMA
A:
[140-352]
---------------------------------------------
A
Y
V
K
I
S
-
D
G
C
D
R
G
C
T
F
C
S
I
P
S
F
KG
S
--
L
R
-----
S
-
R
-
S
I
E
D
I
T
R
E
V
E
D
-----
L
L
K
E
G
K
----
K
E
I
I
L
V
A
Q
D
-
T
T
S
-
Y
-
G
I
--
D
L
Y
R
K
QA
L
P
D
L
L
R
R
L
N
S
L
N
G
E
F
W
I
R
V
M
Y
L
H
P
D
H
L
T
E
E
I
I
S
A
M
L
E
L
D
KV
V
K
Y
F
D
V
P
V
Q
H
G
S
D
K
I
L
K
L
M
-
G
---
R
---
T
K
S
S
E
E
L
K
K
M
L
S
S
I
-------
R
E
-
R
F
P
D
A
V
L
R
T
S
I
I
V
G
F
P
G
E
T
E
E
D
F
E
E
L
K
---
Q
F
V
E
------
E
I
--
Q
F
D
K
L
G
A
F
V
Y
S
D
E
E
G
T
V
A
F
N
L
K
E
K
V
D
P
E
M
A
K
R
R
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
46.62
23%
-34
- C2 -
5FF3
6
?
A:
[63-240]
------------------------------------------------------
C
R
K
N
C
L
Y
C
G
L
R
R
-------
D
-----
N
-
K
-
N
L
K
R
Y
-
R
M
T
P
E
E
I
V
E
R
A
R
L
A
V
Q
F
-
G
A
K
T
I
V
L
Q
S
G
------------
E
D
P
Y
---
M
P
D
V
I
S
D
I
V
K
E
I
K
K
M
G
-
V
A
V
T
L
S
L
G
E
W
P
R
E
Y
Y
E
K
W
K
E
A
G
--
A
D
R
Y
L
L
R
H
E
T
A
N
P
V
L
--------------
H
R
K
L
R
P
D
T
S
F
E
N
R
L
N
C
L
L
T
L
K
E
L
G
Y
E
T
-
G
A
--
G
S
M
V
G
L
P
G
Q
T
I
D
D
L
V
D
D
L
---
L
F
L
K
------
E
H
--
D
F
D
M
V
G
I
G
P
F
I
P
H
P
D
T
P
L
A
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
46.23
23%
-34
- C2 -
5FEW
6
?
A:
[73-250]
------------------------------------------------------
C
R
K
N
C
L
Y
C
G
L
R
R
-------
D
-----
N
-
K
-
N
L
K
R
Y
-
R
M
T
P
E
E
I
V
E
R
A
R
L
A
V
Q
F
-
G
A
K
T
I
V
L
Q
S
G
------------
E
D
P
Y
Y
--
M
P
D
V
I
S
D
I
V
K
E
I
K
K
M
G
-
V
A
V
T
L
S
L
G
E
W
P
R
E
Y
Y
E
K
W
K
E
A
G
--
A
D
R
Y
L
L
R
H
E
T
A
N
P
V
L
--------------
H
R
K
L
R
P
D
T
S
F
E
N
R
L
N
C
L
L
T
L
K
E
L
G
Y
E
T
-
G
A
--
G
S
M
V
G
L
P
G
Q
T
I
D
D
L
V
D
D
L
---
L
F
L
K
------
E
H
--
D
F
D
M
V
G
I
G
P
F
I
P
H
P
D
T
P
L
A
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
46.19
23%
-33
- C2 -
5FF4
5
?
A:
[73-250]
------------------------------------------------------
C
R
K
N
C
L
Y
C
G
L
R
R
-------
D
-----
N
-
K
-
N
L
K
R
Y
-
R
M
T
P
E
E
I
V
E
R
A
R
L
A
V
Q
F
-
G
A
K
T
I
V
L
Q
S
G
------------
E
D
P
Y
Y
--
M
P
D
V
I
S
D
I
V
K
E
I
K
K
M
G
-
V
A
V
T
L
S
L
G
E
W
P
R
E
Y
Y
E
K
W
K
E
A
G
--
A
D
R
Y
L
L
R
H
E
T
A
N
P
V
L
--------------
H
R
K
L
R
P
D
T
S
F
E
N
R
L
N
C
L
L
T
L
K
E
L
G
Y
E
T
-
G
A
--
G
S
M
V
G
L
P
G
Q
T
I
D
D
L
V
D
D
L
---
L
F
L
K
------
E
H
--
D
F
D
M
V
G
I
G
P
F
I
P
H
P
D
T
P
L
A
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
46.16
23%
-36
- C2 -
5FF0
6
?
A:
[73-250]
------------------------------------------------------
C
R
K
N
C
L
Y
C
G
L
R
R
-------
D
-----
N
-
K
-
N
L
K
R
Y
-
R
M
T
P
E
E
I
V
E
R
A
R
L
A
V
Q
F
-
G
A
K
T
I
V
L
Q
S
G
------------
E
D
P
Y
Y
--
M
P
D
V
I
S
D
I
V
K
E
I
K
K
M
G
-
V
A
V
T
L
S
L
G
E
W
P
R
E
Y
Y
E
K
W
K
E
A
G
--
A
D
R
Y
L
L
R
H
E
T
A
N
P
V
L
--------------
H
R
K
L
R
P
D
T
S
F
E
N
R
L
N
C
L
L
T
L
K
E
L
G
Y
E
T
-
G
A
--
G
S
M
V
G
L
P
G
Q
T
I
D
D
L
V
D
D
L
---
L
F
L
K
------
E
H
--
D
F
D
M
V
G
I
G
P
F
I
P
H
P
D
T
P
L
A
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
45.96
23%
-35
- C2 -
5FES
5
?
A:
[73-250]
------------------------------------------------------
C
R
K
N
C
L
Y
C
G
L
R
R
-------
D
-----
N
-
K
-
N
L
K
R
Y
-
R
M
T
P
E
E
I
V
E
R
A
R
L
A
V
Q
F
-
G
A
K
T
I
V
L
Q
S
G
------------
E
D
P
Y
---
M
P
D
V
I
S
D
I
V
K
E
I
K
K
M
G
-
V
A
V
T
L
S
L
G
E
W
P
R
E
Y
Y
E
K
W
K
E
A
G
--
A
D
R
Y
L
L
R
H
E
T
A
N
P
V
L
--------------
H
R
K
L
R
P
D
T
S
F
E
N
R
L
N
C
L
L
T
L
K
E
L
G
Y
E
T
-
G
A
--
G
S
M
V
G
L
P
G
Q
T
I
D
D
L
V
D
D
L
---
L
F
L
K
------
E
H
--
D
F
D
M
V
G
I
G
P
F
I
P
H
P
D
T
P
L
A
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Fugue
45.94
15%
21
- C2 -
1TV8
5
MOAA_STAA8
A:
[3-329]
--------------------------------E
Q
I
K
D
KLG
R
P
I
R
D
L
R
L
S
V
T
D
R
-
C
N
F
R
C
D
Y
C
M
P
K
E
V
--
F
--
G
D
-----
D
-
F
-
V
F
L
P
K
N
E
L
L
T
F
D
E
M
A
R
I
A
K
V
Y
A
E
L
G
V
K
K
I
R
I
T
G
G
E
-
P
L
M
----------
R
R
--
D
L
D
V
L
I
A
K
L
N
Q
I
D
G
I
E
D
I
G
L
T
T
N
-
G
L
L
L
K
K
H
G
Q
K
L
Y
D
A
G
--
L
R
R
I
N
V
S
L
D
A
I
D
D
T
L
F
Q
S
I
N
N
---
R
---
N
I
K
A
T
T
I
L
E
Q
I
D
Y
A
-------
T
S
I
G
L
-
N
V
K
V
--
N
V
V
I
-
Q
K
G
I
N
----
D
D
Q
I
---
I
P
M
L
------
E
Y
--
F
K
D
K
H
I
E
I
R
F
I
E
F
M
D
V
G
N
D
N
G
W
D
F
S
K
V
V
-----
T
K
D
E
M
L
T
M
I
E
Q
H
F
E
I
D
P
V
E
P
K
Y
F
G
E
V
A
---------------------------------
K
Y
Y
R
H
K
D
--
N
G
V
Q
--------
F
G
L
I
T
S
V
S
Q
S
F
C
S
T
C
T
R
A
--
R
L
S
--
S
----------
D
G
K
F
Y
G
C
L
F
A
T
V
D
G
F
N
V
K
A
F
I
R
------
S
G
V
T
D
E
E
L
K
E
Q
F
K
A
L
W
Q
I
R
D
D
---
R
Y
---
S
D
---
E
R
T
A
Q
T
V
A
N
R
Q
-------------------------
42
HHSearch
45.89
17%
25
* C2 *
1TV8
4
MOAA_STAA8
A:
[15-200]
--------------------------------------------
D
L
R
L
S
V
T
-
D
R
C
N
F
R
C
D
Y
C
M
P
K
E
V
--
F
--
G
D
DFVFL
P
-
K
-
N
E
L
L
T
F
D
E
M
A
R
I
A
K
V
Y
A
E
----
L
-
G
V
K
K
I
R
I
T
G
G
E
-
P
L
M
-
R
-
R
----
D
L
D
V
--
L
I
A
K
L
N
Q
I
D
G
----
I
E
D
I
G
L
T
T
N
G
L
L
L
K
K
H
-
G
Q
K
L
Y
D
A
G
--
L
R
R
I
N
V
S
L
D
A
I
D
D
T
L
F
Q
S
I
-
N
---
N
R--
N
I
K
A
T
T
I
L
E
Q
I
D
Y
A
-------
T
S
I
G
L
-
N
V
K
V
--
N
V
V
I
Q
-
K
G
I
N
D
D
Q
I
I
P
M
L
---
E
Y
F
K
------
D
K
--
H
I
E
-
I
R
F
I
E
F
M
D
V
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
45.87
23%
-40
- C2 -
4JY8
6
HYDE_THEMA
A:
[73-250]
------------------------------------------------------
C
R
K
N
C
L
Y
C
G
L
R
R
-------
D
-----
N
-
K
-
N
L
K
R
Y
-
R
M
T
P
E
E
I
V
E
R
A
R
L
A
V
Q
F
-
G
A
K
T
I
V
L
Q
S
G
------------
E
D
P
Y
Y
--
M
P
D
V
I
S
D
I
V
K
E
I
K
K
M
G
-
V
A
V
T
L
S
L
G
E
W
P
R
E
Y
Y
E
K
W
K
E
A
G
--
A
D
R
Y
L
L
R
H
E
T
A
N
P
V
L
--------------
H
R
K
L
R
P
D
T
S
F
E
N
R
L
N
C
L
L
T
L
K
E
L
G
Y
E
T
-
G
A
--
G
S
M
V
G
L
P
G
Q
T
I
D
D
L
V
D
D
L
---
L
F
L
K
------
E
H
--
D
F
D
M
V
G
I
G
P
F
I
P
H
P
D
T
P
L
A
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
45.76
23%
-35
- C2 -
5FEZ
6
?
A:
[73-250]
------------------------------------------------------
C
R
K
N
C
L
Y
C
G
L
R
R
-------
D
-----
N
-
K
-
N
L
K
R
Y
-
R
M
T
P
E
E
I
V
E
R
A
R
L
A
V
Q
F
-
G
A
K
T
I
V
L
Q
S
G
------------
E
D
P
Y
Y
--
M
P
D
V
I
S
D
I
V
K
E
I
K
K
M
G
-
V
A
V
T
L
S
L
G
E
W
P
R
E
Y
Y
E
K
W
K
E
A
G
--
A
D
R
Y
L
L
R
H
E
T
A
N
P
V
L
--------------
H
R
K
L
R
P
D
T
S
F
E
N
R
L
N
C
L
L
T
L
K
E
L
G
Y
E
T
-
G
A
--
G
S
M
V
G
L
P
G
Q
T
I
D
D
L
V
D
D
L
---
L
F
L
K
------
E
H
--
D
F
D
M
V
G
I
G
P
F
I
P
H
P
D
T
P
L
A
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
45.71
18%
-7
- C2 -
4RTB
3
?
A:
[107-344]
----------------------------------------------------
I
-
C
I
N
N
C
S
Y
C
S
F
R
R
E
--
N
--
K
E
-----
L
-
S
-
R
V
R
L
S
L
E
E
A
V
D
E
A
K
A
I
R
E
M
-----
G
H
T
R
I
L
L
V
M
G
E
-
E
P
E
D
K
-
T
L
--
S
Y
L
E
E
--
I
I
P
A
I
Y
S
E
V
D
I
------
R
R
I
N
V
N
I
A
P
L
T
L
K
G
Y
E
R
L
K
K
L
K
--
I
G
T
Y
Q
L
F
Q
E
S
Y
N
P
E
V
Y
R
E
V
-
H
---
L
DGP
K
T
N
F
L
W
R
L
N
A
V
E
R
A
-------
I
E
A
G
I
D
D
I
G
I
--
G
A
L
F
G
L
G
D
-
P
L
F
E
L
L
G
V
I
---
A
H
A
D
Y
L
K
K
K
F
G
I
--
G
P
H
T
V
S
V
P
R
L
K
P
A
L
N
S
V
F
S
N
D
------
Y
K
I
S
D
H
K
F
K
K
I
V
A
L
L
R
I
M
L
P
Y
T
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Fugue
45.55
13%
39
- C2 -
3T7V
3
PYLB_METBF
A:
[12-348]
S
L
G
D
K
V
I
E
G
Y
Q
L
T
D
N
D
L
R
T
L
L
S
LES
K
E
G
L
E
R
L
Y
S
A
A
R
K
V
R
D
H
Y
F
G
N
R
V
F
L
N
-
C
-
F
I
Y
F
S
T
Y
C
K
N
Q
C
S
--
F
CY
Y
N
-----
C
-
R
-
N
E
I
N
R
Y
R
L
T
M
E
E
I
K
E
T
C
K
T
L
K
G
A
-
G
F
H
M
V
D
L
T
M
G
E
-
D
P
Y
-
Y
-
Y
E
D
P
N
R
F
V
E
--
L
V
Q
I
V
K
E
E
L
G
L
P
I
M
I
S
-------
P
G
L
M
D
N
A
T
L
L
K
A
R
E
K
G
--
A
N
F
L
A
L
Y
Q
E
T
Y
D
T
E
L
Y
R
K
L
-
R
---
V
---
G
Q
S
F
D
G
R
V
N
A
R
R
F
A
-------
K
Q
Q
G
Y
-
C
V
E
D
--
G
I
L
T
G
V
-
G
N
D
I
E
S
T
I
L
S
L
---
R
G
M
S
------
T
N
--
D
P
D
M
V
R
V
M
T
F
L
P
Q
E
G
T
-------------
P
L
E
G
F
R
D
K
S
N
L
S
E
L
K
I
I
S
V
L
R
L
M
F
P
K
R
L
I
P
A
----
S
L
D
L
----------
E
------------
G
------------------------
I
D
G
M
-
V
L
R
L
N
A
G
A
N
I
V
TS
I
L
P
--
P
D
S
------------
Q
L
E
G
V
A
N
Y
D
R
D
L
E
E
R
D
R
-------------------------
D
I
K
---
S
V
---
V
R
---
R
L
E
I
M
G
M
K
P
A
R
Q
A
D
F
E
A
V
L
-----------------
7
PsiBlast_PDB
45.48
23%
-34
- C2 -
5FEP
5
?
A:
[73-250]
------------------------------------------------------
C
R
K
N
C
L
Y
C
G
L
R
R
-------
D
-----
N
-
K
-
N
L
K
R
Y
-
R
M
T
P
E
E
I
V
E
R
A
R
L
A
V
Q
F
-
G
A
K
T
I
V
L
Q
S
G
------------
E
D
P
Y
---
M
P
D
V
I
S
D
I
V
K
E
I
K
K
M
G
-
V
A
V
T
L
S
L
G
E
W
P
R
E
Y
Y
E
K
W
K
E
A
G
--
A
D
R
Y
L
L
R
H
E
T
A
N
P
V
L
--------------
H
R
K
L
R
P
D
T
S
F
E
N
R
L
N
C
L
L
T
L
K
E
L
G
Y
E
T
-
G
A
--
G
S
M
V
G
L
P
G
Q
T
I
D
D
L
V
D
D
L
---
L
F
L
K
------
E
H
--
D
F
D
M
V
G
I
G
P
F
I
P
H
P
D
T
P
L
A
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
45.44
23%
-33
- C2 -
5FEX
3
?
A:
[73-250]
------------------------------------------------------
C
R
K
N
C
L
Y
C
G
L
R
R
-------
D
-----
N
-
K
-
N
L
K
R
Y
-
R
M
T
P
E
E
I
V
E
R
A
R
L
A
V
Q
F
-
G
A
K
T
I
V
L
Q
S
G
------------
E
D
P
Y
---
M
P
D
V
I
S
D
I
V
K
E
I
K
K
M
G
-
V
A
V
T
L
S
L
G
E
W
P
R
E
Y
Y
E
K
W
K
E
A
G
--
A
D
R
Y
L
L
R
H
E
T
A
N
P
V
L
--------------
H
R
K
L
R
P
D
T
S
F
E
N
R
L
N
C
L
L
T
L
K
E
L
G
Y
E
T
-
G
A
--
G
S
M
V
G
L
P
G
Q
T
I
D
D
L
V
D
D
L
---
L
F
L
K
------
E
H
--
D
F
D
M
V
G
I
G
P
F
I
P
H
P
D
T
P
L
A
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
44.64
15%
18
- C2 -
4WCX
6
?
A:
[97-328]
----------------------------------------------
P
L
Y
V
S
-
N
Y
C
V
N
N
C
R
Y
C
G
Y
R
H
S
--
N
--
E
------
Q
-
Q
-
R
K
K
L
T
M
E
E
V
R
R
E
V
E
I
L
E
E
M
-----
G
H
K
R
L
A
V
E
A
G
E
-
D
P
V
-
N
C
P
I
--
D
Y
I
V
D
--
V
I
K
T
I
Y
D
T
K
-
L
-
K
N
G
S
I
R
R
V
N
V
N
I
A
A
T
T
V
E
N
Y
K
K
L
K
K
V
G
--
I
G
T
Y
V
L
F
Q
E
T
Y
H
R
P
T
Y
E
Y
M
-
H
PQG
P
---
K
H
D
Y
D
Y
H
L
T
A
M
D
R
A
-------
M
E
A
G
I
D
D
V
G
L
--
G
V
L
Y
G
L
Y
D
Y
K
Y
E
T
V
A
M
L
Y
H
A
N
H
L
E
E
------
K
F
GV
G
P
H
T
I
S
V
P
R
L
R
P
A
L
N
I
S
I
D
K
F
-----
P
Y
I
V
S
D
K
D
F
K
K
L
V
A
V
I
R
M
A
V
P
Y
T
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
44.28
13%
-7
- C2 -
3T7V
3
PYLB_METBF
A:
[63-270]
---------------------------------------------
C
F
I
Y
F
S
-
T
Y
C
K
N
Q
C
S
F
C
Y
Y
N
C
R
--
N
--
E
------
I
-
N
-
R
Y
R
L
T
M
E
E
I
K
E
T
C
K
T
L
K
G
A
-----
G
F
H
M
V
D
L
T
M
G
E
D
P
Y
Y
-
Y
E
D
P
--
N
R
F
V
E
--
L
V
Q
I
V
K
E
E
L
G
-------
L
P
I
M
I
S
P
G
L
M
D
N
A
T
L
L
K
A
R
E
K
G
--
A
N
F
L
A
L
Y
Q
E
T
Y
D
T
E
L
Y
R
K
L
-
R
---
V
---
G
Q
S
F
D
G
R
V
N
A
R
R
F
A
-------
K
Q
Q
G
Y
-
C
V
E
D
--
G
I
L
T
G
V
G
N
-
D
I
E
S
T
I
L
S
L
---
R
G
M
S
------
T
N
--
D
P
D
M
V
R
V
M
T
F
L
P
Q
E
G
T
P
L
E
G
F
R
------
D
K
S
N
L
S
E
L
K
I
I
S
V
L
R
L
M
F
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------